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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAC1-PKM (FusionGDB2 ID:71626)

Fusion Gene Summary for RAC1-PKM

check button Fusion gene summary
Fusion gene informationFusion gene name: RAC1-PKM
Fusion gene ID: 71626
HgeneTgene
Gene symbol

RAC1

PKM

Gene ID

6035

5315

Gene nameribonuclease A family member 1, pancreaticpyruvate kinase M1/2
SynonymsRAC1|RIB1|RNS1CTHBP|HEL-S-30|OIP3|PK3|PKM2|TCB|THBP1|p58
Cytomap

14q11.2

15q23

Type of geneprotein-codingprotein-coding
Descriptionribonuclease pancreaticHP-RNaseRIB-1RNase 1RNase ARNase upI-1ribonuclease 1ribonuclease A C1ribonuclease, RNase A family, 1 (pancreatic)pyruvate kinase PKMOPA-interacting protein 3PK, muscle typecytosolic thyroid hormone-binding proteinepididymis secretory protein Li 30pyruvate kinase 2/3pyruvate kinase isozymes M1/M2pyruvate kinase muscle isozymepyruvate kinase, musclethyroid ho
Modification date2020031320200329
UniProtAcc.

Q99640

Ensembl transtripts involved in fusion geneENST00000348035, ENST00000356142, 
ENST00000488373, 		ENST00000319622, 
ENST00000335181, ENST00000389093, 
ENST00000449901, ENST00000565154, 
ENST00000565184, ENST00000568459, 
ENST00000568883, 
Fusion gene scores* DoF score19 X 12 X 6=136834 X 37 X 9=11322
# samples 1941
** MAII scorelog2(19/1368*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/11322*10)=-4.78736110881616
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAC1 [Title/Abstract] AND PKM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAC1(6442108)-PKM(72499561), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAC1

GO:0051607

defense response to virus

9826755

HgeneRAC1

GO:0090501

RNA phosphodiester bond hydrolysis

9826755

TgenePKM

GO:0012501

programmed cell death

17308100


check buttonFusion gene breakpoints across RAC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PKM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACD365065RAC1chr7

6442108

-PKMchr15

72499561

+


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Fusion Gene ORF analysis for RAC1-PKM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000348035ENST00000319622RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000348035ENST00000335181RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000348035ENST00000389093RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000348035ENST00000449901RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000348035ENST00000565154RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000348035ENST00000565184RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000348035ENST00000568459RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000348035ENST00000568883RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000356142ENST00000319622RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000356142ENST00000335181RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000356142ENST00000389093RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000356142ENST00000449901RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000356142ENST00000565154RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000356142ENST00000565184RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000356142ENST00000568459RAC1chr7

6442108

-PKMchr15

72499561

+
3UTR-3CDSENST00000356142ENST00000568883RAC1chr7

6442108

-PKMchr15

72499561

+
In-frameENST00000488373ENST00000319622RAC1chr7

6442108

-PKMchr15

72499561

+
In-frameENST00000488373ENST00000335181RAC1chr7

6442108

-PKMchr15

72499561

+
In-frameENST00000488373ENST00000389093RAC1chr7

6442108

-PKMchr15

72499561

+
In-frameENST00000488373ENST00000449901RAC1chr7

6442108

-PKMchr15

72499561

+
In-frameENST00000488373ENST00000565154RAC1chr7

6442108

-PKMchr15

72499561

+
In-frameENST00000488373ENST00000565184RAC1chr7

6442108

-PKMchr15

72499561

+
In-frameENST00000488373ENST00000568459RAC1chr7

6442108

-PKMchr15

72499561

+
In-frameENST00000488373ENST00000568883RAC1chr7

6442108

-PKMchr15

72499561

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000488373RAC1chr76442108-ENST00000319622PKMchr1572499561+2169845258809183
ENST00000488373RAC1chr76442108-ENST00000565184PKMchr1572499561+2166845258809183
ENST00000488373RAC1chr76442108-ENST00000389093PKMchr1572499561+2166845258809183
ENST00000488373RAC1chr76442108-ENST00000335181PKMchr1572499561+2166845258809183
ENST00000488373RAC1chr76442108-ENST00000568883PKMchr1572499561+2166845258809183
ENST00000488373RAC1chr76442108-ENST00000449901PKMchr1572499561+2093845258809183
ENST00000488373RAC1chr76442108-ENST00000565154PKMchr1572499561+1608845258809183
ENST00000488373RAC1chr76442108-ENST00000568459PKMchr1572499561+1569845258809183

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000488373ENST00000319622RAC1chr76442108-PKMchr1572499561+0.295440880.70455915
ENST00000488373ENST00000565184RAC1chr76442108-PKMchr1572499561+0.290056440.7099436
ENST00000488373ENST00000389093RAC1chr76442108-PKMchr1572499561+0.290056440.7099436
ENST00000488373ENST00000335181RAC1chr76442108-PKMchr1572499561+0.308326630.6916734
ENST00000488373ENST00000568883RAC1chr76442108-PKMchr1572499561+0.290056440.7099436
ENST00000488373ENST00000449901RAC1chr76442108-PKMchr1572499561+0.382917460.61708254
ENST00000488373ENST00000565154RAC1chr76442108-PKMchr1572499561+0.0086504970.99134946
ENST00000488373ENST00000568459RAC1chr76442108-PKMchr1572499561+0.0102034770.9897966

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Fusion Genomic Features for RAC1-PKM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAC1-PKM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:6442108/chr15:72499561)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PKM

Q99640

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:9001210}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePKMchr7:6442108chr15:72499561ENST0000031962201175_780532.0Nucleotide bindingATP
TgenePKMchr7:6442108chr15:72499561ENST0000033518101175_780532.0Nucleotide bindingATP
TgenePKMchr7:6442108chr15:72499561ENST0000038909301175_780532.0Nucleotide bindingATP
TgenePKMchr7:6442108chr15:72499561ENST0000044990101175_780517.0Nucleotide bindingATP
TgenePKMchr7:6442108chr15:72499561ENST0000056515401275_780532.0Nucleotide bindingATP
TgenePKMchr7:6442108chr15:72499561ENST0000056518401175_780532.0Nucleotide bindingATP
TgenePKMchr7:6442108chr15:72499561ENST0000056845901175_780532.0Nucleotide bindingATP
TgenePKMchr7:6442108chr15:72499561ENST00000319622011432_4370532.0RegionD-fructose 1%2C6-bisphosphate binding%3B part of allosteric site
TgenePKMchr7:6442108chr15:72499561ENST00000319622011516_5210532.0RegionD-fructose 1%2C6-bisphosphate binding%3B part of allosteric site
TgenePKMchr7:6442108chr15:72499561ENST00000335181011432_4370532.0RegionD-fructose 1%2C6-bisphosphate binding%3B part of allosteric site
TgenePKMchr7:6442108chr15:72499561ENST00000335181011516_5210532.0RegionD-fructose 1%2C6-bisphosphate binding%3B part of allosteric site
TgenePKMchr7:6442108chr15:72499561ENST00000389093011432_4370532.0RegionD-fructose 1%2C6-bisphosphate binding%3B part of allosteric site
TgenePKMchr7:6442108chr15:72499561ENST00000389093011516_5210532.0RegionD-fructose 1%2C6-bisphosphate binding%3B part of allosteric site
TgenePKMchr7:6442108chr15:72499561ENST00000449901011432_4370517.0RegionD-fructose 1%2C6-bisphosphate binding%3B part of allosteric site
TgenePKMchr7:6442108chr15:72499561ENST00000449901011516_5210517.0RegionD-fructose 1%2C6-bisphosphate binding%3B part of allosteric site
TgenePKMchr7:6442108chr15:72499561ENST00000565154012432_4370532.0RegionD-fructose 1%2C6-bisphosphate binding%3B part of allosteric site
TgenePKMchr7:6442108chr15:72499561ENST00000565154012516_5210532.0RegionD-fructose 1%2C6-bisphosphate binding%3B part of allosteric site
TgenePKMchr7:6442108chr15:72499561ENST00000565184011432_4370532.0RegionD-fructose 1%2C6-bisphosphate binding%3B part of allosteric site
TgenePKMchr7:6442108chr15:72499561ENST00000565184011516_5210532.0RegionD-fructose 1%2C6-bisphosphate binding%3B part of allosteric site
TgenePKMchr7:6442108chr15:72499561ENST00000568459011432_4370532.0RegionD-fructose 1%2C6-bisphosphate binding%3B part of allosteric site
TgenePKMchr7:6442108chr15:72499561ENST00000568459011516_5210532.0RegionD-fructose 1%2C6-bisphosphate binding%3B part of allosteric site

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAC1chr7:6442108chr15:72499561ENST00000348035-1632_400193.0MotifEffector region
HgeneRAC1chr7:6442108chr15:72499561ENST00000356142-1732_400212.0MotifEffector region
HgeneRAC1chr7:6442108chr15:72499561ENST00000348035-16116_1180193.0Nucleotide bindingGTP
HgeneRAC1chr7:6442108chr15:72499561ENST00000348035-1613_180193.0Nucleotide bindingGTP
HgeneRAC1chr7:6442108chr15:72499561ENST00000348035-16159_1600193.0Nucleotide bindingGTP
HgeneRAC1chr7:6442108chr15:72499561ENST00000348035-1630_350193.0Nucleotide bindingGTP
HgeneRAC1chr7:6442108chr15:72499561ENST00000356142-17116_1180212.0Nucleotide bindingGTP
HgeneRAC1chr7:6442108chr15:72499561ENST00000356142-1713_180212.0Nucleotide bindingGTP
HgeneRAC1chr7:6442108chr15:72499561ENST00000356142-17159_1600212.0Nucleotide bindingGTP
HgeneRAC1chr7:6442108chr15:72499561ENST00000356142-1730_350212.0Nucleotide bindingGTP


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Fusion Gene Sequence for RAC1-PKM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71626_71626_1_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000319622_length(transcript)=2169nt_BP=845nt
GCCGCTGCCGGGCATCGGCTTCCAGTCCGCGGAGGGCGAGGCGGCGTGGACAGCGGCCCCGGCACCCAGCGCCCCGCCGCCCGCAAGCCG
CGCGCCCGTCCGCCGCGCCCCGAGCCCGCCGCTTCCTATCTCAGCGCCCTGCCGCCGCCGCCGCGGCCCAGCGAGCGGCCCTGATGCAGG
CCATCAAGTGTGTGGTGGTGGGAGACGGAAACAAGAATCTCAGTGTAACCCGAGCAAAATCGCGCGTCTCAGCGTTGCTTGTATAGAGCT
GTAGGTAAAACTTGCCTACTGATCAGTTACACAACCAATGCATTTCCTGGAGAATATATCCCTACTGTCTTTGACAATTATTCTGCCAAT
GTTATGGTAGATGGAAAACCGGTGAATCTGGGCTTATGGGATACAGCTGGACAAGAAGATTATGACAGATTACGCCCCCTATCCTATCCG
CAAACAGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCAC
CACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAG
CTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGA
GGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAA
ATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGCAAGGCCCGAGGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATG
GCGCCCTGGCTCCGGCTTCACCAACACCATGCGTGTTGTTCCTGTGCCGTGATGGACCCCAGAGCCCCTCCTCCAGCCCCTGTCCCACCC
CCTTCCCCCAGCCCATCCATTAGGCCAGCAACGCTTGTAGAACTCACTCTGGGCTGTAACGTGGCACTGGTAGGTTGGGACACCAGGGAA
GAAGATCAACGCCTCACTGAAACATGGCTGTGTTTGCAGCCTGCTCTAGTGGGACAGCCCAGAGCCTGGCTGCCCATCATGTGGCCCCAC
CCAATCAAGGGAAGAAGGAGGAATGCTGGACTGGAGGCCCCTGGAGCCAGATGGCAAGAGGGTGACAGCTTCCTTTCCTGTGTGTACTCT
GTCCAGTTCCTTTAGAAAAAATGGATGCCCAGAGGACTCCCAACCCTGGCTTGGGGTCAAGAAACAGCCAGCAAGAGTTAGGGGCCTTAG
GGCACTGGGCTGTTGTTCCATTGAAGCCGACTCTGGCCCTGGCCCTTACTTGCTTCTCTAGCTCTCTAGGCCTCTCCAGTTTGCACCTGT
CCCCACCCTCCACTCAGCTGTCCTGCAGCAAACACTCCACCCTCCACCTTCCATTTTCCCCCACTACTGCAGCACCTCCAGGCCTGTTGC
TATAGAGCCTACCTGTATGTCAATAAACAACAGCTGAAGCACCGTCTGCTCACCAGGTGGCCAGATACCGCCCACGTGCCCCCATCATTG
CTGTGACCCGGAATCCCCAGACAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCCCTGTGCTGTGCAAGGACCCAGTCCAGGAGGCCT
GGGCTGAGGACGTGGACCTCCGGGTGAACTTTGCCATGAATGTTGATAGCTCGTGAGGCTGAGGCAGCCATGTTCCACCGCAAGCTGTTT
GAAGAACTTGTGCGAGCCTCAAGTCACTCCACAGACCTCATGGAAGCCATGGCCATGGGCAGCGTGGAGGCTTCTTATAAGTGTTTAGCA
GCAGCTTTGATAGTTCTGACGGAGTCTGGCAGATGCTGGAGAGCATGATCAAGAAGCCCCGCCCCACTCGGGCTGAAGGCAGTGATGTGG
CCAATGCAGTCCTGGATGGAGCCGACTGCATCATGCTGTCTGGAGAAACAGCCAAAGGGGACTATCCTCTGGAGGCTGTGCGCATGCAGC
ACCTGCATTGAGATTCCTGCAGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGACGGTGCAACCGAGCTGGGAAGCCTGTCATCTGT

>71626_71626_1_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000319622_length(amino acids)=183AA_BP=
MYRAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYP
EVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKC

--------------------------------------------------------------
>71626_71626_2_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000335181_length(transcript)=2166nt_BP=845nt
GCCGCTGCCGGGCATCGGCTTCCAGTCCGCGGAGGGCGAGGCGGCGTGGACAGCGGCCCCGGCACCCAGCGCCCCGCCGCCCGCAAGCCG
CGCGCCCGTCCGCCGCGCCCCGAGCCCGCCGCTTCCTATCTCAGCGCCCTGCCGCCGCCGCCGCGGCCCAGCGAGCGGCCCTGATGCAGG
CCATCAAGTGTGTGGTGGTGGGAGACGGAAACAAGAATCTCAGTGTAACCCGAGCAAAATCGCGCGTCTCAGCGTTGCTTGTATAGAGCT
GTAGGTAAAACTTGCCTACTGATCAGTTACACAACCAATGCATTTCCTGGAGAATATATCCCTACTGTCTTTGACAATTATTCTGCCAAT
GTTATGGTAGATGGAAAACCGGTGAATCTGGGCTTATGGGATACAGCTGGACAAGAAGATTATGACAGATTACGCCCCCTATCCTATCCG
CAAACAGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCAC
CACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAG
CTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGA
GGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAA
ATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGCAAGGCCCGAGGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATG
GCGCCCTGGCTCCGGCTTCACCAACACCATGCGTGTTGTTCCTGTGCCGTGATGGACCCCAGAGCCCCTCCTCCAGCCCCTGTCCCACCC
CCTTCCCCCAGCCCATCCATTAGGCCAGCAACGCTTGTAGAACTCACTCTGGGCTGTAACGTGGCACTGGTAGGTTGGGACACCAGGGAA
GAAGATCAACGCCTCACTGAAACATGGCTGTGTTTGCAGCCTGCTCTAGTGGGACAGCCCAGAGCCTGGCTGCCCATCATGTGGCCCCAC
CCAATCAAGGGAAGAAGGAGGAATGCTGGACTGGAGGCCCCTGGAGCCAGATGGCAAGAGGGTGACAGCTTCCTTTCCTGTGTGTACTCT
GTCCAGTTCCTTTAGAAAAAATGGATGCCCAGAGGACTCCCAACCCTGGCTTGGGGTCAAGAAACAGCCAGCAAGAGTTAGGGGCCTTAG
GGCACTGGGCTGTTGTTCCATTGAAGCCGACTCTGGCCCTGGCCCTTACTTGCTTCTCTAGCTCTCTAGGCCTCTCCAGTTTGCACCTGT
CCCCACCCTCCACTCAGCTGTCCTGCAGCAAACACTCCACCCTCCACCTTCCATTTTCCCCCACTACTGCAGCACCTCCAGGCCTGTTGC
TATAGAGCCTACCTGTATGTCAATAAACAACAGCTGAAGCGTCTGCTCACCAGGTGGCCAGATACCGCCCACGTGCCCCCATCATTGCTG
TGACCCGGAATCCCCAGACAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCCCTGTGCTGTGCAAGGACCCAGTCCAGGAGGCCTGGG
CTGAGGACGTGGACCTCCGGGTGAACTTTGCCATGAATGTTGATTGCCCGTGAGGCAGAGGCTGCCATCTACCACTTGCAATTATTTGAG
GAACTCCGCCGCCTGGCGCCCATTACCAGCGACCCCACAGAAGCCACCGCCGTGGGTGCCGTGGAGGCCTCCTTCAAGTGCTGCAGTGGG
GCCATAATCGTCCTCACCAAGTCTGGCAGATGCTGGAGAGCATGATCAAGAAGCCCCGCCCCACTCGGGCTGAAGGCAGTGATGTGGCCA
ATGCAGTCCTGGATGGAGCCGACTGCATCATGCTGTCTGGAGAAACAGCCAAAGGGGACTATCCTCTGGAGGCTGTGCGCATGCAGCACC
TGCATTGAGATTCCTGCAGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGACGGTGCAACCGAGCTGGGAAGCCTGTCATCTGTGCT

>71626_71626_2_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000335181_length(amino acids)=183AA_BP=
MYRAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYP
EVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKC

--------------------------------------------------------------
>71626_71626_3_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000389093_length(transcript)=2166nt_BP=845nt
GCCGCTGCCGGGCATCGGCTTCCAGTCCGCGGAGGGCGAGGCGGCGTGGACAGCGGCCCCGGCACCCAGCGCCCCGCCGCCCGCAAGCCG
CGCGCCCGTCCGCCGCGCCCCGAGCCCGCCGCTTCCTATCTCAGCGCCCTGCCGCCGCCGCCGCGGCCCAGCGAGCGGCCCTGATGCAGG
CCATCAAGTGTGTGGTGGTGGGAGACGGAAACAAGAATCTCAGTGTAACCCGAGCAAAATCGCGCGTCTCAGCGTTGCTTGTATAGAGCT
GTAGGTAAAACTTGCCTACTGATCAGTTACACAACCAATGCATTTCCTGGAGAATATATCCCTACTGTCTTTGACAATTATTCTGCCAAT
GTTATGGTAGATGGAAAACCGGTGAATCTGGGCTTATGGGATACAGCTGGACAAGAAGATTATGACAGATTACGCCCCCTATCCTATCCG
CAAACAGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCAC
CACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAG
CTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGA
GGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAA
ATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGCAAGGCCCGAGGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATG
GCGCCCTGGCTCCGGCTTCACCAACACCATGCGTGTTGTTCCTGTGCCGTGATGGACCCCAGAGCCCCTCCTCCAGCCCCTGTCCCACCC
CCTTCCCCCAGCCCATCCATTAGGCCAGCAACGCTTGTAGAACTCACTCTGGGCTGTAACGTGGCACTGGTAGGTTGGGACACCAGGGAA
GAAGATCAACGCCTCACTGAAACATGGCTGTGTTTGCAGCCTGCTCTAGTGGGACAGCCCAGAGCCTGGCTGCCCATCATGTGGCCCCAC
CCAATCAAGGGAAGAAGGAGGAATGCTGGACTGGAGGCCCCTGGAGCCAGATGGCAAGAGGGTGACAGCTTCCTTTCCTGTGTGTACTCT
GTCCAGTTCCTTTAGAAAAAATGGATGCCCAGAGGACTCCCAACCCTGGCTTGGGGTCAAGAAACAGCCAGCAAGAGTTAGGGGCCTTAG
GGCACTGGGCTGTTGTTCCATTGAAGCCGACTCTGGCCCTGGCCCTTACTTGCTTCTCTAGCTCTCTAGGCCTCTCCAGTTTGCACCTGT
CCCCACCCTCCACTCAGCTGTCCTGCAGCAAACACTCCACCCTCCACCTTCCATTTTCCCCCACTACTGCAGCACCTCCAGGCCTGTTGC
TATAGAGCCTACCTGTATGTCAATAAACAACAGCTGAAGCGTCTGCTCACCAGGTGGCCAGATACCGCCCACGTGCCCCCATCATTGCTG
TGACCCGGAATCCCCAGACAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCCCTGTGCTGTGCAAGGACCCAGTCCAGGAGGCCTGGG
CTGAGGACGTGGACCTCCGGGTGAACTTTGCCATGAATGTTGATAGCTCGTGAGGCTGAGGCAGCCATGTTCCACCGCAAGCTGTTTGAA
GAACTTGTGCGAGCCTCAAGTCACTCCACAGACCTCATGGAAGCCATGGCCATGGGCAGCGTGGAGGCTTCTTATAAGTGTTTAGCAGCA
GCTTTGATAGTTCTGACGGAGTCTGGCAGATGCTGGAGAGCATGATCAAGAAGCCCCGCCCCACTCGGGCTGAAGGCAGTGATGTGGCCA
ATGCAGTCCTGGATGGAGCCGACTGCATCATGCTGTCTGGAGAAACAGCCAAAGGGGACTATCCTCTGGAGGCTGTGCGCATGCAGCACC
TGCATTGAGATTCCTGCAGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGACGGTGCAACCGAGCTGGGAAGCCTGTCATCTGTGCT

>71626_71626_3_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000389093_length(amino acids)=183AA_BP=
MYRAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYP
EVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKC

--------------------------------------------------------------
>71626_71626_4_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000449901_length(transcript)=2093nt_BP=845nt
GCCGCTGCCGGGCATCGGCTTCCAGTCCGCGGAGGGCGAGGCGGCGTGGACAGCGGCCCCGGCACCCAGCGCCCCGCCGCCCGCAAGCCG
CGCGCCCGTCCGCCGCGCCCCGAGCCCGCCGCTTCCTATCTCAGCGCCCTGCCGCCGCCGCCGCGGCCCAGCGAGCGGCCCTGATGCAGG
CCATCAAGTGTGTGGTGGTGGGAGACGGAAACAAGAATCTCAGTGTAACCCGAGCAAAATCGCGCGTCTCAGCGTTGCTTGTATAGAGCT
GTAGGTAAAACTTGCCTACTGATCAGTTACACAACCAATGCATTTCCTGGAGAATATATCCCTACTGTCTTTGACAATTATTCTGCCAAT
GTTATGGTAGATGGAAAACCGGTGAATCTGGGCTTATGGGATACAGCTGGACAAGAAGATTATGACAGATTACGCCCCCTATCCTATCCG
CAAACAGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCAC
CACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAG
CTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGA
GGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAA
ATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGCAAGGCCCGAGGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATG
GCGCCCTGGCTCCGGCTTCACCAACACCATGCGTGTTGTTCCTGTGCCGTGATGGACCCCAGAGCCCCTCCTCCAGCCCCTGTCCCACCC
CCTTCCCCCAGCCCATCCATTAGGCCAGCAACGCTTGTAGAACTCACTCTGGGCTGTAACGTGGCACTGGTAGGTTGGGACACCAGGGAA
GAAGATCAACGCCTCACTGAAACATGGCTGTGTTTGCAGCCTGCTCTAGTGGGACAGCCCAGAGCCTGGCTGCCCATCATGTGGCCCCAC
CCAATCAAGGGAAGAAGGAGGAATGCTGGACTGGAGGCCCCTGGAGCCAGATGGCAAGAGGGTGACAGCTTCCTTTCCTGTGTGTACTCT
GTCCAGTTCCTTTAGAAAAAATGGATGCCCAGAGGACTCCCAACCCTGGCTTGGGGTCAAGAAACAGCCAGCAAGAGTTAGGGGCCTTAG
GGCACTGGGCTGTTGTTCCATTGAAGCCGACTCTGGCCCTGGCCCTTACTTGCTTCTCTAGCTCTCTAGGCCTCTCCAGTTTGCACCTGT
CCCCACCCTCCACTCAGCTGTCCTGCAGCAAACACTCCACCCTCCACCTTCCATTTTGTCTGCTCACCAGGTGGCCAGATACCGCCCACG
TGCCCCCATCATTGCTGTGACCCGGAATCCCCAGACAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCCCTGTGCTGTGCAAGGACCC
AGTCCAGGAGGCCTGGGCTGAGGACGTGGACCTCCGGGTGAACTTTGCCATGAATGTTGATTGCCCGTGAGGCAGAGGCTGCCATCTACC
ACTTGCAATTATTTGAGGAACTCCGCCGCCTGGCGCCCATTACCAGCGACCCCACAGAAGCCACCGCCGTGGGTGCCGTGGAGGCCTCCT
TCAAGTGCTGCAGTGGGGCCATAATCGTCCTCACCAAGTCTGGCAGATGCTGGAGAGCATGATCAAGAAGCCCCGCCCCACTCGGGCTGA
AGGCAGTGATGTGGCCAATGCAGTCCTGGATGGAGCCGACTGCATCATGCTGTCTGGAGAAACAGCCAAAGGGGACTATCCTCTGGAGGC
TGTGCGCATGCAGCACCTGCATTGAGATTCCTGCAGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGACGGTGCAACCGAGCTGGGA

>71626_71626_4_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000449901_length(amino acids)=183AA_BP=
MYRAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYP
EVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKC

--------------------------------------------------------------
>71626_71626_5_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000565154_length(transcript)=1608nt_BP=845nt
GCCGCTGCCGGGCATCGGCTTCCAGTCCGCGGAGGGCGAGGCGGCGTGGACAGCGGCCCCGGCACCCAGCGCCCCGCCGCCCGCAAGCCG
CGCGCCCGTCCGCCGCGCCCCGAGCCCGCCGCTTCCTATCTCAGCGCCCTGCCGCCGCCGCCGCGGCCCAGCGAGCGGCCCTGATGCAGG
CCATCAAGTGTGTGGTGGTGGGAGACGGAAACAAGAATCTCAGTGTAACCCGAGCAAAATCGCGCGTCTCAGCGTTGCTTGTATAGAGCT
GTAGGTAAAACTTGCCTACTGATCAGTTACACAACCAATGCATTTCCTGGAGAATATATCCCTACTGTCTTTGACAATTATTCTGCCAAT
GTTATGGTAGATGGAAAACCGGTGAATCTGGGCTTATGGGATACAGCTGGACAAGAAGATTATGACAGATTACGCCCCCTATCCTATCCG
CAAACAGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCAC
CACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAG
CTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGA
GGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAA
ATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGCAAGGCCCGAGGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATG
GCGCCCTGGCTCCGGCTTCACCAACACCATGCGTGTTGTTCCTGTGCCGTGATGGACCCCAGAGCCCCTCCTCCAGCCCCTGTCCCACCC
CCTTCCCCCAGCCCATCCATTAGTCTGCTCACCAGGTGGCCAGATACCGCCCACGTGCCCCCATCATTGCTGTGACCCGGAATCCCCAGA
CAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCCCTGTGCTGTGCAAGGACCCAGTCCAGGAGGCCTGGGCTGAGGACGTGGACCTCC
GGGTGAACTTTGCCATGAATGTTGATAGCTCGTGAGGCTGAGGCAGCCATGTTCCACCGCAAGCTGTTTGAAGAACTTGTGCGAGCCTCA
AGTCACTCCACAGACCTCATGGAAGCCATGGCCATGGGCAGCGTGGAGGCTTCTTATAAGTGTTTAGCAGCAGCTTTGATAGTTCTGACG
GAGTCTGGCAGATGCTGGAGAGCATGATCAAGAAGCCCCGCCCCACTCGGGCTGAAGGCAGTGATGTGGCCAATGCAGTCCTGGATGGAG
CCGACTGCATCATGCTGTCTGGAGAAACAGCCAAAGGGGACTATCCTCTGGAGGCTGTGCGCATGCAGCACCTGCATTGAGATTCCTGCA

>71626_71626_5_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000565154_length(amino acids)=183AA_BP=
MYRAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYP
EVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKC

--------------------------------------------------------------
>71626_71626_6_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000565184_length(transcript)=2166nt_BP=845nt
GCCGCTGCCGGGCATCGGCTTCCAGTCCGCGGAGGGCGAGGCGGCGTGGACAGCGGCCCCGGCACCCAGCGCCCCGCCGCCCGCAAGCCG
CGCGCCCGTCCGCCGCGCCCCGAGCCCGCCGCTTCCTATCTCAGCGCCCTGCCGCCGCCGCCGCGGCCCAGCGAGCGGCCCTGATGCAGG
CCATCAAGTGTGTGGTGGTGGGAGACGGAAACAAGAATCTCAGTGTAACCCGAGCAAAATCGCGCGTCTCAGCGTTGCTTGTATAGAGCT
GTAGGTAAAACTTGCCTACTGATCAGTTACACAACCAATGCATTTCCTGGAGAATATATCCCTACTGTCTTTGACAATTATTCTGCCAAT
GTTATGGTAGATGGAAAACCGGTGAATCTGGGCTTATGGGATACAGCTGGACAAGAAGATTATGACAGATTACGCCCCCTATCCTATCCG
CAAACAGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCAC
CACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAG
CTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGA
GGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAA
ATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGCAAGGCCCGAGGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATG
GCGCCCTGGCTCCGGCTTCACCAACACCATGCGTGTTGTTCCTGTGCCGTGATGGACCCCAGAGCCCCTCCTCCAGCCCCTGTCCCACCC
CCTTCCCCCAGCCCATCCATTAGGCCAGCAACGCTTGTAGAACTCACTCTGGGCTGTAACGTGGCACTGGTAGGTTGGGACACCAGGGAA
GAAGATCAACGCCTCACTGAAACATGGCTGTGTTTGCAGCCTGCTCTAGTGGGACAGCCCAGAGCCTGGCTGCCCATCATGTGGCCCCAC
CCAATCAAGGGAAGAAGGAGGAATGCTGGACTGGAGGCCCCTGGAGCCAGATGGCAAGAGGGTGACAGCTTCCTTTCCTGTGTGTACTCT
GTCCAGTTCCTTTAGAAAAAATGGATGCCCAGAGGACTCCCAACCCTGGCTTGGGGTCAAGAAACAGCCAGCAAGAGTTAGGGGCCTTAG
GGCACTGGGCTGTTGTTCCATTGAAGCCGACTCTGGCCCTGGCCCTTACTTGCTTCTCTAGCTCTCTAGGCCTCTCCAGTTTGCACCTGT
CCCCACCCTCCACTCAGCTGTCCTGCAGCAAACACTCCACCCTCCACCTTCCATTTTCCCCCACTACTGCAGCACCTCCAGGCCTGTTGC
TATAGAGCCTACCTGTATGTCAATAAACAACAGCTGAAGCGTCTGCTCACCAGGTGGCCAGATACCGCCCACGTGCCCCCATCATTGCTG
TGACCCGGAATCCCCAGACAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCCCTGTGCTGTGCAAGGACCCAGTCCAGGAGGCCTGGG
CTGAGGACGTGGACCTCCGGGTGAACTTTGCCATGAATGTTGATAGCTCGTGAGGCTGAGGCAGCCATGTTCCACCGCAAGCTGTTTGAA
GAACTTGTGCGAGCCTCAAGTCACTCCACAGACCTCATGGAAGCCATGGCCATGGGCAGCGTGGAGGCTTCTTATAAGTGTTTAGCAGCA
GCTTTGATAGTTCTGACGGAGTCTGGCAGATGCTGGAGAGCATGATCAAGAAGCCCCGCCCCACTCGGGCTGAAGGCAGTGATGTGGCCA
ATGCAGTCCTGGATGGAGCCGACTGCATCATGCTGTCTGGAGAAACAGCCAAAGGGGACTATCCTCTGGAGGCTGTGCGCATGCAGCACC
TGCATTGAGATTCCTGCAGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGACGGTGCAACCGAGCTGGGAAGCCTGTCATCTGTGCT

>71626_71626_6_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000565184_length(amino acids)=183AA_BP=
MYRAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYP
EVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKC

--------------------------------------------------------------
>71626_71626_7_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000568459_length(transcript)=1569nt_BP=845nt
GCCGCTGCCGGGCATCGGCTTCCAGTCCGCGGAGGGCGAGGCGGCGTGGACAGCGGCCCCGGCACCCAGCGCCCCGCCGCCCGCAAGCCG
CGCGCCCGTCCGCCGCGCCCCGAGCCCGCCGCTTCCTATCTCAGCGCCCTGCCGCCGCCGCCGCGGCCCAGCGAGCGGCCCTGATGCAGG
CCATCAAGTGTGTGGTGGTGGGAGACGGAAACAAGAATCTCAGTGTAACCCGAGCAAAATCGCGCGTCTCAGCGTTGCTTGTATAGAGCT
GTAGGTAAAACTTGCCTACTGATCAGTTACACAACCAATGCATTTCCTGGAGAATATATCCCTACTGTCTTTGACAATTATTCTGCCAAT
GTTATGGTAGATGGAAAACCGGTGAATCTGGGCTTATGGGATACAGCTGGACAAGAAGATTATGACAGATTACGCCCCCTATCCTATCCG
CAAACAGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCAC
CACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAG
CTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGA
GGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAA
ATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGCAAGGCCCGAGGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATG
GCGCCCTGGCTCCGGCTTCACCAACACCATGCGTGTTGTTCCTGTGCCGTGATGGACCCCAGAGCCCCTCCTCGTCTGCTCACCAGGTGG
CCAGATACCGCCCACGTGCCCCCATCATTGCTGTGACCCGGAATCCCCAGACAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCCCTG
TGCTGTGCAAGGACCCAGTCCAGGAGGCCTGGGCTGAGGACGTGGACCTCCGGGTGAACTTTGCCATGAATGTTGATAGCTCGTGAGGCT
GAGGCAGCCATGTTCCACCGCAAGCTGTTTGAAGAACTTGTGCGAGCCTCAAGTCACTCCACAGACCTCATGGAAGCCATGGCCATGGGC
AGCGTGGAGGCTTCTTATAAGTGTTTAGCAGCAGCTTTGATAGTTCTGACGGAGTCTGGCAGATGCTGGAGAGCATGATCAAGAAGCCCC
GCCCCACTCGGGCTGAAGGCAGTGATGTGGCCAATGCAGTCCTGGATGGAGCCGACTGCATCATGCTGTCTGGAGAAACAGCCAAAGGGG
ACTATCCTCTGGAGGCTGTGCGCATGCAGCACCTGCATTGAGATTCCTGCAGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGACGG

>71626_71626_7_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000568459_length(amino acids)=183AA_BP=
MYRAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYP
EVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKC

--------------------------------------------------------------
>71626_71626_8_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000568883_length(transcript)=2166nt_BP=845nt
GCCGCTGCCGGGCATCGGCTTCCAGTCCGCGGAGGGCGAGGCGGCGTGGACAGCGGCCCCGGCACCCAGCGCCCCGCCGCCCGCAAGCCG
CGCGCCCGTCCGCCGCGCCCCGAGCCCGCCGCTTCCTATCTCAGCGCCCTGCCGCCGCCGCCGCGGCCCAGCGAGCGGCCCTGATGCAGG
CCATCAAGTGTGTGGTGGTGGGAGACGGAAACAAGAATCTCAGTGTAACCCGAGCAAAATCGCGCGTCTCAGCGTTGCTTGTATAGAGCT
GTAGGTAAAACTTGCCTACTGATCAGTTACACAACCAATGCATTTCCTGGAGAATATATCCCTACTGTCTTTGACAATTATTCTGCCAAT
GTTATGGTAGATGGAAAACCGGTGAATCTGGGCTTATGGGATACAGCTGGACAAGAAGATTATGACAGATTACGCCCCCTATCCTATCCG
CAAACAGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCAC
CACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAG
CTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGA
GGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAA
ATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGCAAGGCCCGAGGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATG
GCGCCCTGGCTCCGGCTTCACCAACACCATGCGTGTTGTTCCTGTGCCGTGATGGACCCCAGAGCCCCTCCTCCAGCCCCTGTCCCACCC
CCTTCCCCCAGCCCATCCATTAGGCCAGCAACGCTTGTAGAACTCACTCTGGGCTGTAACGTGGCACTGGTAGGTTGGGACACCAGGGAA
GAAGATCAACGCCTCACTGAAACATGGCTGTGTTTGCAGCCTGCTCTAGTGGGACAGCCCAGAGCCTGGCTGCCCATCATGTGGCCCCAC
CCAATCAAGGGAAGAAGGAGGAATGCTGGACTGGAGGCCCCTGGAGCCAGATGGCAAGAGGGTGACAGCTTCCTTTCCTGTGTGTACTCT
GTCCAGTTCCTTTAGAAAAAATGGATGCCCAGAGGACTCCCAACCCTGGCTTGGGGTCAAGAAACAGCCAGCAAGAGTTAGGGGCCTTAG
GGCACTGGGCTGTTGTTCCATTGAAGCCGACTCTGGCCCTGGCCCTTACTTGCTTCTCTAGCTCTCTAGGCCTCTCCAGTTTGCACCTGT
CCCCACCCTCCACTCAGCTGTCCTGCAGCAAACACTCCACCCTCCACCTTCCATTTTCCCCCACTACTGCAGCACCTCCAGGCCTGTTGC
TATAGAGCCTACCTGTATGTCAATAAACAACAGCTGAAGCGTCTGCTCACCAGGTGGCCAGATACCGCCCACGTGCCCCCATCATTGCTG
TGACCCGGAATCCCCAGACAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCCCTGTGCTGTGCAAGGACCCAGTCCAGGAGGCCTGGG
CTGAGGACGTGGACCTCCGGGTGAACTTTGCCATGAATGTTGATAGCTCGTGAGGCTGAGGCAGCCATGTTCCACCGCAAGCTGTTTGAA
GAACTTGTGCGAGCCTCAAGTCACTCCACAGACCTCATGGAAGCCATGGCCATGGGCAGCGTGGAGGCTTCTTATAAGTGTTTAGCAGCA
GCTTTGATAGTTCTGACGGAGTCTGGCAGATGCTGGAGAGCATGATCAAGAAGCCCCGCCCCACTCGGGCTGAAGGCAGTGATGTGGCCA
ATGCAGTCCTGGATGGAGCCGACTGCATCATGCTGTCTGGAGAAACAGCCAAAGGGGACTATCCTCTGGAGGCTGTGCGCATGCAGCACC
TGCATTGAGATTCCTGCAGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGACGGTGCAACCGAGCTGGGAAGCCTGTCATCTGTGCT

>71626_71626_8_RAC1-PKM_RAC1_chr7_6442108_ENST00000488373_PKM_chr15_72499561_ENST00000568883_length(amino acids)=183AA_BP=
MYRAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYP
EVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RAC1-PKM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePKMchr7:6442108chr15:72499561ENST00000319622011307_5310532.0POU5F1
TgenePKMchr7:6442108chr15:72499561ENST00000335181011307_5310532.0POU5F1
TgenePKMchr7:6442108chr15:72499561ENST00000389093011307_5310532.0POU5F1
TgenePKMchr7:6442108chr15:72499561ENST00000449901011307_5310517.0POU5F1
TgenePKMchr7:6442108chr15:72499561ENST00000565154012307_5310532.0POU5F1
TgenePKMchr7:6442108chr15:72499561ENST00000565184011307_5310532.0POU5F1
TgenePKMchr7:6442108chr15:72499561ENST00000568459011307_5310532.0POU5F1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAC1-PKM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAC1-PKM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource