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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAD17-CNTN5 (FusionGDB2 ID:71681)

Fusion Gene Summary for RAD17-CNTN5

check button Fusion gene summary
Fusion gene informationFusion gene name: RAD17-CNTN5
Fusion gene ID: 71681
HgeneTgene
Gene symbol

RAD17

CNTN5

Gene ID

5884

53942

Gene nameRAD17 checkpoint clamp loader componentcontactin 5
SynonymsCCYC|HRAD17|R24L|RAD17SP|RAD24HNB-2s|NB-2
Cytomap

5q13.2

11q22.1

Type of geneprotein-codingprotein-coding
Descriptioncell cycle checkpoint protein RAD17RAD1 homologRAD17 homologRF-C activator 1 homologRad17-like proteincell cycle checkpoint protein (RAD17)contactin-5neural adhesion moleculeneural recognition molecule NB-2
Modification date2020031320200329
UniProtAcc.

O94779

Ensembl transtripts involved in fusion geneENST00000282891, ENST00000305138, 
ENST00000345306, ENST00000354312, 
ENST00000354868, ENST00000358030, 
ENST00000361732, ENST00000380774, 
ENST00000509734, ENST00000521422, 
ENST00000504177, 		ENST00000524560, 
ENST00000279463, ENST00000418526, 
ENST00000524871, ENST00000527185, 
ENST00000528682, 
Fusion gene scores* DoF score3 X 3 X 3=2718 X 15 X 12=3240
# samples 419
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(19/3240*10)=-4.09192248944104
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAD17 [Title/Abstract] AND CNTN5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAD17(68677884)-CNTN5(100226848), # samples:3
CNTN5(100059984)-RAD17(68710625), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RAD17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CNTN5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TM-A84I-01ARAD17chr5

68677884

-CNTN5chr11

100226848

+
ChimerDB4LGGTCGA-TM-A84I-01ARAD17chr5

68677884

+CNTN5chr11

100226848

+
ChimerDB4LGGTCGA-TM-A84IRAD17chr5

68677884

+CNTN5chr11

100226848

+


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Fusion Gene ORF analysis for RAD17-CNTN5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000282891ENST00000524560RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-3UTRENST00000305138ENST00000524560RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-3UTRENST00000345306ENST00000524560RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-3UTRENST00000354312ENST00000524560RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-3UTRENST00000354868ENST00000524560RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-3UTRENST00000358030ENST00000524560RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-3UTRENST00000361732ENST00000524560RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-3UTRENST00000380774ENST00000524560RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-3UTRENST00000509734ENST00000524560RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-3UTRENST00000521422ENST00000524560RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000282891ENST00000279463RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000282891ENST00000418526RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000282891ENST00000524871RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000282891ENST00000527185RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000282891ENST00000528682RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000305138ENST00000279463RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000305138ENST00000418526RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000305138ENST00000524871RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000305138ENST00000527185RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000305138ENST00000528682RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000345306ENST00000279463RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000345306ENST00000418526RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000345306ENST00000524871RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000345306ENST00000527185RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000345306ENST00000528682RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000354312ENST00000279463RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000354312ENST00000418526RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000354312ENST00000524871RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000354312ENST00000527185RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000354312ENST00000528682RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000354868ENST00000279463RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000354868ENST00000418526RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000354868ENST00000524871RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000354868ENST00000527185RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000354868ENST00000528682RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000358030ENST00000279463RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000358030ENST00000418526RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000358030ENST00000524871RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000358030ENST00000527185RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000358030ENST00000528682RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000361732ENST00000279463RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000361732ENST00000418526RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000361732ENST00000524871RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000361732ENST00000527185RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000361732ENST00000528682RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000380774ENST00000279463RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000380774ENST00000418526RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000380774ENST00000524871RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000380774ENST00000527185RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000380774ENST00000528682RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000509734ENST00000279463RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000509734ENST00000418526RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000509734ENST00000524871RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000509734ENST00000527185RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000509734ENST00000528682RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000521422ENST00000279463RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000521422ENST00000418526RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000521422ENST00000524871RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000521422ENST00000527185RAD17chr5

68677884

+CNTN5chr11

100226848

+
5CDS-intronENST00000521422ENST00000528682RAD17chr5

68677884

+CNTN5chr11

100226848

+
intron-3UTRENST00000504177ENST00000524560RAD17chr5

68677884

+CNTN5chr11

100226848

+
intron-intronENST00000504177ENST00000279463RAD17chr5

68677884

+CNTN5chr11

100226848

+
intron-intronENST00000504177ENST00000418526RAD17chr5

68677884

+CNTN5chr11

100226848

+
intron-intronENST00000504177ENST00000524871RAD17chr5

68677884

+CNTN5chr11

100226848

+
intron-intronENST00000504177ENST00000527185RAD17chr5

68677884

+CNTN5chr11

100226848

+
intron-intronENST00000504177ENST00000528682RAD17chr5

68677884

+CNTN5chr11

100226848

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for RAD17-CNTN5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RAD17chr568677884+CNTN5chr11100226847+5.78E-070.9999994
RAD17chr568677884+CNTN5chr11100226847+5.78E-070.9999994
RAD17chr568677884+CNTN5chr11100226847+5.78E-070.9999994
RAD17chr568677884+CNTN5chr11100226847+5.78E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RAD17-CNTN5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:68677884/:100226848)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CNTN5

O94779

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for RAD17-CNTN5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RAD17-CNTN5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAD17-CNTN5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAD17-CNTN5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource