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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RAD50-C5orf56 (FusionGDB2 ID:71722)

Fusion Gene Summary for RAD50-C5orf56

Fusion gene summary

Fusion gene information	Fusion gene name: RAD50-C5orf56
	Fusion gene ID: 71722
		Hgene	Tgene
	Gene symbol	RAD50	C5orf56
	Gene ID	10111	441108
	Gene name	RAD50 double strand break repair protein	IRF1 antisense RNA 1
	Synonyms	NBSLD\|RAD502\|hRad50	C5orf56
	Cytomap	5q31.1	5q31.1
	Type of gene	protein-coding	ncRNA
	Description	DNA repair protein RAD50RAD50 homolog, double strand break repair protein	uncharacterized protein C5orf56
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000265335, ENST00000378823, ENST00000487596,	ENST00000464024, ENST00000337752, ENST00000378947, ENST00000378953, ENST00000407797,
Fusion gene scores	* DoF score	9 X 7 X 7=441	5 X 4 X 5=100
	# samples	10	5
	** MAII score	log2(10/441*10)=-2.1407786557828 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RAD50 [Title/Abstract] AND C5orf56 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RAD50(131895059)-C5orf56(131785342), # samples:2 C5orf56(131755632)-RAD50(131894976), # samples:1 C5orf56(131785381)-RAD50(131894976), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RAD50	GO:0000019	regulation of mitotic recombination	8756642
Hgene	RAD50	GO:0006281	DNA repair	9705271
Hgene	RAD50	GO:0006310	DNA recombination	9705271
Hgene	RAD50	GO:0006974	cellular response to DNA damage stimulus	17500065
Hgene	RAD50	GO:0007004	telomere maintenance via telomerase	9705271
Hgene	RAD50	GO:0031954	positive regulation of protein autophosphorylation	15790808
Hgene	RAD50	GO:0033674	positive regulation of kinase activity	15790808
Hgene	RAD50	GO:1904354	negative regulation of telomere capping	17694070

Fusion gene breakpoints across RAD50 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C5orf56 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-BC-A10T-01A	RAD50	chr5	131895059	-	C5orf56	chr5	131785342	+
ChimerDB4	LIHC	TCGA-BC-A10T-01A	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+

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Fusion Gene ORF analysis for RAD50-C5orf56

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000265335	ENST00000464024	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+
5UTR-3CDS	ENST00000378823	ENST00000337752	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+
5UTR-3CDS	ENST00000378823	ENST00000378947	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+
5UTR-3CDS	ENST00000378823	ENST00000378953	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+
5UTR-3CDS	ENST00000378823	ENST00000407797	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+
5UTR-intron	ENST00000378823	ENST00000464024	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+
In-frame	ENST00000265335	ENST00000337752	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+
In-frame	ENST00000265335	ENST00000378947	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+
In-frame	ENST00000265335	ENST00000378953	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+
In-frame	ENST00000265335	ENST00000407797	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+
intron-3CDS	ENST00000487596	ENST00000337752	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+
intron-3CDS	ENST00000487596	ENST00000378947	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+
intron-3CDS	ENST00000487596	ENST00000378953	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+
intron-3CDS	ENST00000487596	ENST00000407797	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+
intron-intron	ENST00000487596	ENST00000464024	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000265335

RAD50

chr5

131895059

ENST00000378953

C5orf56

chr5

131785342

1018

600

360

905

181

ENST00000265335

RAD50

chr5

131895059

ENST00000337752

C5orf56

chr5

131785342

2446

600

360

932

190

ENST00000265335

RAD50

chr5

131895059

ENST00000378947

C5orf56

chr5

131785342

1050

600

360

794

144

ENST00000265335

RAD50

chr5

131895059

ENST00000407797

C5orf56

chr5

131785342

1509

600

527

979

150

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000265335	ENST00000378953	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+	0.028892629	0.97110736
ENST00000265335	ENST00000337752	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+	0.11705442	0.88294554
ENST00000265335	ENST00000378947	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+	0.058295216	0.94170475
ENST00000265335	ENST00000407797	RAD50	chr5	131895059	+	C5orf56	chr5	131785342	+	0.18945058	0.81054944

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Fusion Genomic Features for RAD50-C5orf56

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RAD50	chr5	131895059	+	C5orf56	chr5	131785341	+	5.94E-06	0.99999404
RAD50	chr5	131895059	+	C5orf56	chr5	131785341	+	5.94E-06	0.99999404

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAD50-C5orf56

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:131895059/chr5:131785342)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000265335

36_43

1313.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000265335

228_359

1313.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000265335

401_598

1313.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000265335

635_673

1313.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000265335

706_734

1313.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000265335

789_1079

1313.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000378823

228_359

1174.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000378823

401_598

1174.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000378823

635_673

1174.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000378823

706_734

1174.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000378823

789_1079

1174.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000265335

1201_1238

1313.0

Compositional bias

Note=Ala/Asp-rich (DA-box)

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000378823

1201_1238

1174.0

Compositional bias

Note=Ala/Asp-rich (DA-box)

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000265335

635_734

1313.0

Domain

Zinc-hook

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000378823

635_734

1174.0

Domain

Zinc-hook

Hgene

RAD50

chr5:131895059

chr5:131785342

ENST00000378823

36_43

1174.0

Nucleotide binding

ATP

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Fusion Gene Sequence for RAD50-C5orf56

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>71722_71722_1_RAD50-C5orf56_RAD50_chr5_131895059_ENST00000265335_C5orf56_chr5_131785342_ENST00000337752_length(transcript)=2446nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGCCAGAGTTTGTAGCCTATTGGAGGAAA
ACACACCAAGGGAATCTTCAAACTCTTCTTCTCCACTGGCTCCTGCTGTGCTCCTGTCTCCATCACCTGTATAATGCTTCCTGCCATCCT
GCCTTCCCCGTGGAGTACAGCCATGCTGTCTGCTGCTTACAGCCAAGATTCTGGAAAGAAATGTCTCCTTTTTCCTCGTCATCAACCACT
CATTTATTCAGCAAGTGTTTCTTTTACACTTGCCTGTGCTGGGCATGGCAGCAATGCAGCAGTGAACAAAACCATCAGCCCTGCTCTCAT
GCAGCTTATAATCAAGTAGAGAGACAGACATAAATGATTAATAGATGCTCCTGTAATGGTGGTTGTGAGGTGTGCTGCCACAGCCCAGCC
ACACACGCCAGTTCCCTTCTCTGCACATGTACATGTCTGCTCATCCTTCCCACCTGAACTCATGTGCCACCTCACTTATGCCCCTTCCCA
ATGCCGCACCCACACAACAGGGTGTCCCTCTGTGCCCACAGCAGCCCTTGGGTATAACTGTTCCCCACAGAGGCTGAACCCCAAGGGCAG
AGTCCAGGCCACACTCACCACGGAGACCCCTGCCTGGCACAGAGCCCAGCCCAGCAGAGATGCTCAGAAGATGAATGAAAGTCCCTGCTG
AGATTGATCCAATCTGTTTGTGAACATCTCTGGGGTCCAAGAATTCACGGCTTTCTTTTTCTTTAGAGAGCCTTTTGTTTCTTTTTGCCA
TTATATACTATATTTGGGTTAGGGCACAACAATGTGAATATACTTAATACTGAACTCTACACTTGAAAATGGTTAAGATGGTAAAGTTTT
AAGTTATATGTATTTTGCCACAATTTTTTAAAATGCAGAGCATAGGTACAAAGAAGGAAAAAAAGGGGGCAAGGTCCATTTTATTGAGAA
ATAAAGAACAAAGGGTTCAATTCAGAGAGGATTGGATTTTAAAACGTAATTTAGATTAGGGAAATGCAAATGAAAACCATAATAAGTAAG
ATACCACTTCACATCTGTTAGGATGGCTATTTTAAAACAACAAAAACAACCTGAAAATAAGTGTTGGCAAGGATGTGAAGAAATAGATAC
CCTTGTGCATTGCTATTGGGAACGTAAAATCATGCAGCCTTTGTTGAAAACAATGTGGTGGTTCCTCAAAAACTTAGTTATCATATGATC
CCGCAGTTCCACTTCTAGGAATATACCCAAAAGAATTGAAAGCAGGGACTCAAAGTGATATTTGTACACCAGTGTTTGTAGCAGTATTAT
TCACAATAGCCAAAAGGTGGAAACAACCCAGATGTCCATGACAAGAGGAGTGGATAAACAAAATATGGTGAATATGTACAATGGAACATA
ATTCAGCTTTAAAAAGGAATGAAATTCTGGTACATGTTATAACATAGATGAACCTTAAAAACATTATGCTAAGTGAAATAAGCCAGACAC
AGAAGGAAAAATACCAGATGATCCCACTTATATGAGGTACCTAGAATAGTGAAATTCATAGAGACAGAAAGTAGAAGGATGGTTGCCAGG
GGCTGGAAGGAGGAAGAACAGGGAGATACTGCTTAGTGGATGCAGAGTTTATGTTGAGGGTGATGAAAAAGTTCTGGAGATGGATGGTGG
TGATGGCTGCACAACAGTGAGAATGTACTTCATACTATGGAACTCTGCACTTAAAAATGGTTAAAATGGATGTAGACATTTTATGTCTAT
TTTGCCATAACAAGAAAGTAATTTGGGTGTATTTTAGAGATTTTAGAAAATACTGTAAGCACAAGAGGAAAAAAATTAAAATCATTCGCA

>71722_71722_1_RAD50-C5orf56_RAD50_chr5_131895059_ENST00000265335_C5orf56_chr5_131785342_ENST00000337752_length(amino acids)=190AA_BP=80
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVPEFVAYWRK
THQGNLQTLLLHWLLLCSCLHHLYNASCHPAFPVEYSHAVCCLQPRFWKEMSPFSSSSTTHLFSKCFFYTCLCWAWQQCSSEQNHQPCSH

--------------------------------------------------------------
>71722_71722_2_RAD50-C5orf56_RAD50_chr5_131895059_ENST00000265335_C5orf56_chr5_131785342_ENST00000378947_length(transcript)=1050nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGCCAGAGTTTGTAGCCTATTGGAGGAAA
ACACACCAAGCCTACGCCACTCTGTGCCCTTTAGCCAAGGAAGCCCAGCTGAGGCCCCGCAGCGTCCCTGCCCAGCAGAGCTACAGGAGG
CCCGAGGCCCCTTCCTGTTCACTCTTGCTCTATAGACGCCACGCTGCAAAGCAGATGTGCAGGGACACCACCTGAAGACCCAGCCTGCAG
CTCAGCCCTACACACTGTGGATGGTGGAGATCCCAGAGGGCCAAGAGAAGCTTATTGAGACTTCTCTGCACTGCCCCTCCCACAGCAGGA
GGTTCATGGCCCATGCATTTCTGGGAGGGTTGACAGGGCCCAGGTTGTGGAATACCTGTCTGTGAGCCCCATGTCCTGTCTTGTCCCAGC

>71722_71722_2_RAD50-C5orf56_RAD50_chr5_131895059_ENST00000265335_C5orf56_chr5_131785342_ENST00000378947_length(amino acids)=144AA_BP=80
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVPEFVAYWRK

--------------------------------------------------------------
>71722_71722_3_RAD50-C5orf56_RAD50_chr5_131895059_ENST00000265335_C5orf56_chr5_131785342_ENST00000378953_length(transcript)=1018nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGCCAGAGTTTGTAGCCTATTGGAGGAAA
ACACACCAAGATCACCTCTGCAGCCTGCACAGCCGGGCCTTTGGACTCCTGGATGCTAGAGTGACCTGGGCGCTGAGGAGGGCCCCCGAG
CCAGTACCAGGAAAGGATAGACTCCTGCTTGCAGCATTCCCAGCAGAGGCATCGCCTGTGGACACCGCGTCTGTGTCTGTATATGGCAGA
GCTCCCAGATATATGCACAAGGGAGTGAAAAAATGTGTTTGCACCCCAGTCTCTAAAAATTCAACAGCCTGGTTACTTCTGGGTGGTATA
TCGTAGGTGGCTTTAATACGTGTTATTTGCTCATCTGTATTTCTTACTCTTTGCACAATTAAACCATGTTCCTTTTACTTATGTACATTT

>71722_71722_3_RAD50-C5orf56_RAD50_chr5_131895059_ENST00000265335_C5orf56_chr5_131785342_ENST00000378953_length(amino acids)=181AA_BP=80
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVPEFVAYWRK
THQDHLCSLHSRAFGLLDARVTWALRRAPEPVPGKDRLLLAAFPAEASPVDTASVSVYGRAPRYMHKGVKKCVCTPVSKNSTAWLLLGGI

--------------------------------------------------------------
>71722_71722_4_RAD50-C5orf56_RAD50_chr5_131895059_ENST00000265335_C5orf56_chr5_131785342_ENST00000407797_length(transcript)=1509nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGCCAGAGTTTGTAGCCTATTGGAGGAAA
ACACACCAAGCCCCGAACAGCACAGTGAATGGATAGGGCAGCAGATGAGCTCTGCCCCACGCCGGCCCTGTTTCAGAACAGCACTCCAGA
GTGCCGCACTGCTTGCTGAACCACAGCTGTTACTGCAGATTGAGGAGCCTCAGAGGGAACAGAAGATAAAGATCATTATGGAATTTAGGA
TTGCAGGACATTCTTTGACATTTCATAACAGCCAGGGGAGATCAACTGTGGTCAGGGGACAGGGGCAGGAAGAAACCATGGCCAAGGCCT
GTCTGGCAGGACTTGAAGGGGCAGAGGGACCCTTGCAAATGACCCTGCCTGGAACCCACCCCCAGTTGGCCCCTGTATAGCACTGATCCA
GCTGGGGCTTTTATCCCAGGATACCCTCTTCAGGGATGCCTGTATTTGTTGATTATCTGCCATATGCCTGGTCACTGCAGAATACAAGGA
AGAAAATAGCCTTCAGCAGAAGCTGAGACAGGAGCCTAGAGGATGGACAGTAAGGAGTCGAAGGCTCAGGATGAGGCTTTCCTGACTTTC
TCCCCTAGAGGACTGATGTTCTCTACTGGTACAGACCTTGTTTTATTCATCCTTATGTCCCTAACCTGGAATGGGCCCAGGGTGACAGTT
ATAATAAGTGTTTGTCAAGTGAGCAAGTGTGTGGAGTGTGCATTGTAGAGAGTAAGGTCTCTACAGGATCCTGCTGGAGAGGCAGCCCAC
TGGGCTCACCACTTCTCCAGAGGAGGGACTGGTCCCTTGCCAGACAGCCCTGCCAGCTGGAGCAGGCTTCCTCAGGGGTGCCTGGAGCTG

>71722_71722_4_RAD50-C5orf56_RAD50_chr5_131895059_ENST00000265335_C5orf56_chr5_131785342_ENST00000407797_length(amino acids)=150AA_BP=24
MSKIYLYWRFPSWNQRKYICTRSQGARVCSLLEENTPSPEQHSEWIGQQMSSAPRRPCFRTALQSAALLAEPQLLLQIEEPQREQKIKII

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Top

Fusion Gene PPI Analysis for RAD50-C5orf56

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RAD50-C5orf56

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for RAD50-C5orf56

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source