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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAD50-CADPS (FusionGDB2 ID:71723)

Fusion Gene Summary for RAD50-CADPS

check button Fusion gene summary
Fusion gene informationFusion gene name: RAD50-CADPS
Fusion gene ID: 71723
HgeneTgene
Gene symbol

RAD50

CADPS

Gene ID

10111

8618

Gene nameRAD50 double strand break repair proteincalcium dependent secretion activator
SynonymsNBSLD|RAD502|hRad50CADPS1|CAPS|CAPS1|UNC-31
Cytomap

5q31.1

3p14.2

Type of geneprotein-codingprotein-coding
DescriptionDNA repair protein RAD50RAD50 homolog, double strand break repair proteincalcium-dependent secretion activator 1CAPS-1Ca++-dependent secretion activatorCa2+ dependent secretion activatorCa2+-dependent activator protein for secretionCa2+-regulated cytoskeletal proteincalcium-dependent activator protein for secretion 1
Modification date2020032020200313
UniProtAcc.

Q86UW7

Ensembl transtripts involved in fusion geneENST00000265335, ENST00000378823, 
ENST00000487596, 		ENST00000462768, 
ENST00000490353, ENST00000283269, 
ENST00000357948, ENST00000383710, 
Fusion gene scores* DoF score9 X 7 X 7=4416 X 5 X 5=150
# samples 107
** MAII scorelog2(10/441*10)=-2.1407786557828
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAD50 [Title/Abstract] AND CADPS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAD50(131911620)-CADPS(62578423), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAD50

GO:0000019

regulation of mitotic recombination

8756642

HgeneRAD50

GO:0006281

DNA repair

9705271

HgeneRAD50

GO:0006310

DNA recombination

9705271

HgeneRAD50

GO:0006974

cellular response to DNA damage stimulus

17500065

HgeneRAD50

GO:0007004

telomere maintenance via telomerase

9705271

HgeneRAD50

GO:0031954

positive regulation of protein autophosphorylation

15790808

HgeneRAD50

GO:0033674

positive regulation of kinase activity

15790808

HgeneRAD50

GO:1904354

negative regulation of telomere capping

17694070


check buttonFusion gene breakpoints across RAD50 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CADPS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-7014-01ARAD50chr5

131911620

-CADPSchr3

62578423

-
ChimerDB4LGGTCGA-DU-7014-01ARAD50chr5

131911620

+CADPSchr3

62578423

-


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Fusion Gene ORF analysis for RAD50-CADPS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265335ENST00000462768RAD50chr5

131911620

+CADPSchr3

62578423

-
5CDS-intronENST00000265335ENST00000490353RAD50chr5

131911620

+CADPSchr3

62578423

-
5UTR-3CDSENST00000378823ENST00000283269RAD50chr5

131911620

+CADPSchr3

62578423

-
5UTR-3CDSENST00000378823ENST00000357948RAD50chr5

131911620

+CADPSchr3

62578423

-
5UTR-3CDSENST00000378823ENST00000383710RAD50chr5

131911620

+CADPSchr3

62578423

-
5UTR-intronENST00000378823ENST00000462768RAD50chr5

131911620

+CADPSchr3

62578423

-
5UTR-intronENST00000378823ENST00000490353RAD50chr5

131911620

+CADPSchr3

62578423

-
In-frameENST00000265335ENST00000283269RAD50chr5

131911620

+CADPSchr3

62578423

-
In-frameENST00000265335ENST00000357948RAD50chr5

131911620

+CADPSchr3

62578423

-
In-frameENST00000265335ENST00000383710RAD50chr5

131911620

+CADPSchr3

62578423

-
intron-3CDSENST00000487596ENST00000283269RAD50chr5

131911620

+CADPSchr3

62578423

-
intron-3CDSENST00000487596ENST00000357948RAD50chr5

131911620

+CADPSchr3

62578423

-
intron-3CDSENST00000487596ENST00000383710RAD50chr5

131911620

+CADPSchr3

62578423

-
intron-intronENST00000487596ENST00000462768RAD50chr5

131911620

+CADPSchr3

62578423

-
intron-intronENST00000487596ENST00000490353RAD50chr5

131911620

+CADPSchr3

62578423

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265335RAD50chr5131911620+ENST00000383710CADPSchr362578423-454875236034881042
ENST00000265335RAD50chr5131911620+ENST00000357948CADPSchr362578423-43087523603251963
ENST00000265335RAD50chr5131911620+ENST00000283269CADPSchr362578423-380675236033711003

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265335ENST00000383710RAD50chr5131911620+CADPSchr362578423-9.88E-050.9999012
ENST00000265335ENST00000357948RAD50chr5131911620+CADPSchr362578423-0.0001454090.99985456
ENST00000265335ENST00000283269RAD50chr5131911620+CADPSchr362578423-0.0003239840.999676

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Fusion Genomic Features for RAD50-CADPS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAD50-CADPS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:131911620/chr3:62578423)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CADPS

Q86UW7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAD50chr5:131911620chr3:62578423ENST00000265335+32536_431211313.0Nucleotide bindingATP
TgeneCADPSchr5:131911620chr3:62578423ENST00000283269528521_6244411315.0DomainPH
TgeneCADPSchr5:131911620chr3:62578423ENST00000283269528931_11114411315.0DomainMHD1
TgeneCADPSchr5:131911620chr3:62578423ENST00000357948527521_6244411275.0DomainPH
TgeneCADPSchr5:131911620chr3:62578423ENST00000357948527931_11114411275.0DomainMHD1
TgeneCADPSchr5:131911620chr3:62578423ENST00000383710530521_6244411354.0DomainPH
TgeneCADPSchr5:131911620chr3:62578423ENST00000383710530931_11114411354.0DomainMHD1
TgeneCADPSchr5:131911620chr3:62578423ENST0000049035307380_4950458.0DomainC2
TgeneCADPSchr5:131911620chr3:62578423ENST0000049035307521_6240458.0DomainPH
TgeneCADPSchr5:131911620chr3:62578423ENST0000049035307931_11110458.0DomainMHD1
TgeneCADPSchr5:131911620chr3:62578423ENST000002832695281177_13534411315.0RegionMediates targeting and association with DCVs
TgeneCADPSchr5:131911620chr3:62578423ENST000003579485271177_13534411275.0RegionMediates targeting and association with DCVs
TgeneCADPSchr5:131911620chr3:62578423ENST000003837105301177_13534411354.0RegionMediates targeting and association with DCVs
TgeneCADPSchr5:131911620chr3:62578423ENST00000490353071177_13530458.0RegionMediates targeting and association with DCVs

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAD50chr5:131911620chr3:62578423ENST00000265335+325228_3591211313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131911620chr3:62578423ENST00000265335+325401_5981211313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131911620chr3:62578423ENST00000265335+325635_6731211313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131911620chr3:62578423ENST00000265335+325706_7341211313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131911620chr3:62578423ENST00000265335+325789_10791211313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131911620chr3:62578423ENST00000378823+325228_35901174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131911620chr3:62578423ENST00000378823+325401_59801174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131911620chr3:62578423ENST00000378823+325635_67301174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131911620chr3:62578423ENST00000378823+325706_73401174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131911620chr3:62578423ENST00000378823+325789_107901174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131911620chr3:62578423ENST00000265335+3251201_12381211313.0Compositional biasNote=Ala/Asp-rich (DA-box)
HgeneRAD50chr5:131911620chr3:62578423ENST00000378823+3251201_123801174.0Compositional biasNote=Ala/Asp-rich (DA-box)
HgeneRAD50chr5:131911620chr3:62578423ENST00000265335+325635_7341211313.0DomainZinc-hook
HgeneRAD50chr5:131911620chr3:62578423ENST00000378823+325635_73401174.0DomainZinc-hook
HgeneRAD50chr5:131911620chr3:62578423ENST00000378823+32536_4301174.0Nucleotide bindingATP
TgeneCADPSchr5:131911620chr3:62578423ENST00000283269528380_4954411315.0DomainC2
TgeneCADPSchr5:131911620chr3:62578423ENST00000357948527380_4954411275.0DomainC2
TgeneCADPSchr5:131911620chr3:62578423ENST00000383710530380_4954411354.0DomainC2


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Fusion Gene Sequence for RAD50-CADPS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71723_71723_1_RAD50-CADPS_RAD50_chr5_131911620_ENST00000265335_CADPS_chr3_62578423_ENST00000283269_length(transcript)=3806nt_BP=752nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTTGCTCAAGAAACAGATGTGAGAGCCCAG
ATTCGTCTGCAATTTCGTGATGTCAATGGAGAACTTATAGCTGTGCAAAGATCTATGGTGTGTACTCAGAAAAGCAAAAAGACAGAATTT
AAAACTCTGGAAGGAGTCATTACTAGAACAAACTGGGGCACCCAGGGTGACTTCTCCACAACCCATGCACTGCCAGCTGTGAAGGTGAAG
CTGTTCACAGAGAGCACAGGCGTCCTGGCGTTGGAGGACAAGGAGCTTGGGCGGGTTATTCTCCATCCCACCCCGAACAGCCCCAAACAG
TCAGAGTGGCACAAAATGACAGTCTCCAAAAACTGCCCCGACCAAGATCTCAAAATCAAACTTGCTGTCCGAATGGATAAGCCTCAAAAC
ATGAAGCATTCTGGGTATTTATGGGCCATCGGTAAGAATGTCTGGAAGAGATGGAAGAAAAGGTTTTTTGTATTGGTGCAGGTCAGTCAG
TACACGTTTGCCATGTGCAGTTATCGGGAGAAGAAAGCGGAGCCTCAGGAACTTCTACAATTGGATGGCTACACTGTGGATTACACCGAC
CCCCAGCCAGGTTTGGAGGGTGGCCGAGCCTTCTTCAATGCTGTCAAGGAGGGAGACACCGTGATATTTGCCAGTGACGATGAACAAGAC
CGCATCCTGTGGGTCCAGGCCATGTATCGGGCCACGGGGCAGTCACACAAGCCTGTGCCCCCGACCCAAGTCCAGAAACTCAACGCCAAG
GGAGGAAATGTACCTCAGCTGGATGCCCCTATCTCTCAATTTTACGCAGATAGAGCTCAAAAACATGGCATGGATGAATTTATCTCTTCC
AACCCCTGTAACTTTGACCACGCTTCCCTCTTTGAGATGGTACAACGCCTTACTTTGGATCACAGACTTAATGATTCCTATTCTTGCCTG
GGCTGGTTCAGTCCTGGCCAGGTGTTTGTACTAGACGAGTATTGCGCCCGAAATGGAGTCCGGGGGTGTCACCGACATCTCTGCTACCTC
AGAGACTTGCTTGAACGGGCAGAAAATGGCGCCATGATCGACCCCACCCTTCTTCACTACAGCTTTGCCTTCTGTGCATCCCATGTCCAT
GGGAACAGGCCTGATGGAATTGGAACTGTGACTGTTGAAGAAAAGGAACGTTTTGAAGAAATCAAAGAGAGGCTCCGAGTTCTGCTAGAA
AATCAGATTACACATTTTAGGTATTGCTTTCCATTTGGTCGACCTGAAGGTGCTTTGAAAGCTACTCTCTCACTCTTGGAAAGGGTTTTG
ATGAAAGATATTGTTACCCCAGTGCCACAAGAGGAGGTAAAAACAGTTATCCGTAAATGTCTGGAACAGGCTGCGTTAGTCAACTATTCT
CGGCTCTCAGAGTATGCCAAAATCGAAGGGAAAAAGAGAGAAATGTATGAGCATCCTGTCTTCTGCTTGGCCTCCCAAGTGATGGATTTA
ACCATTCAAAATGTAGGCCGGTTAATCACTCCTGCCAAAAAGCTTGAAGATACAATACGTCTTGCTGAACTAGTCATTGAAGTTCTTCAG
CAAAATGAGGAGCACCACGCAGAGGCCTTTGCGTGGTGGTCAGATTTAATGGTGGAGCATGCGGAGACGTTCCTGTCACTCTTTGCAGTA
GACATGGATGCAGCCTTAGAGGTGCAACCTCCAGACACATGGGACAGTTTTCCACTATTTCAGCTGCTGAATGATTTTCTCCGTACTGAC
TATAATTTGTGCAATGGAAAATTTCACAAACACCTGCAAGACCTGTTTGCCCCACTTGTTGTTAGATATGTGGATCTGATGGAGTCCTCA
ATTGCACAATCCATTCACAGGGGCTTTGAGCGGGAGTCATGGGAACCAGTCAATAATGGGTCAGGCACCTCAGAAGATCTGTTTTGGAAA
CTTGACGCCCTTCAGACCTTCATTCGGGACCTGCACTGGCCTGAAGAAGAGTTTGGAAAGCACCTGGAACAACGGCTGAAGTTGATGGCA
AGTGACATGATCGAATCTTGTGTCAAAAGAACCAGGATTGCATTTGAAGTTAAGCTGCAAAAAACCAGTCGATCAACAGATTTTCGAGTC
CCACAGTCAATATGCACCATGTTTAATGTTATGGTTGATGCCAAAGCTCAATCAACAAAACTTTGCAGCATGGAAATGGGCCAAGAGCAT
CAATACCATTCAAAAATAGACGAACTAATTGAAGAAACTGTTAAAGAAATGATAACACTCTTGGTTGCAAAGTTCGTTACTATCTTGGAA
GGAGTGCTGGCAAAATTATCCAGATATGACGAAGGGACTTTGTTTTCTTCTTTTCTGTCATTTACCGTGAAGGCAGCTTCCAAATATGTG
GATGTACCTAAACCCGGGATGGACGTGGCCGACGCCTACGTGACTTTCGTCCGCCATTCTCAGGATGTCCTGCGTGATAAGGTCAATGAG
GAGATGTACATAGAAAGGTTATTTGATCAATGGTACAACAGCTCCATGAACGTGATCTGCACCTGGTTGACGGACCGGATGGACTTACAG
CTTCATATTTATCAGTTGAAAACACTAATTAGGATGGTAAAGAAAACCTACAGAGATTTCCGATTGCAAGGGGTCCTGGACTCCACCTTA
AACAGCAAGACCTATGAAACGATCCGGAACCGTCTCACTGTGGAGGAAGCCACAGCATCAGTGAGTGAAGGTGGGGGACTGCAGGGCATC
AGCATGAAGGACAGCGATGAGGAAGACGAAGAAGACGATTAGACCATTTGGTCCTAGAGTCTGCTGGGACAGAGTCCTGTAATCAGTGCA
TGTCCTTAGTCTGTTAGTTAAACCCATTAGGAATTTTCTGTCAACTACCATGCCCATGAGATGTTTATCAATACAACTGCCATTTTAGCT
ATGTGGTACCAAGATTAGCAAATGACCTTCATATCCACTGATTTCCTGATGTCCATGTCTATATGTTTACAAGCAATATGGAGCACCATT
CTTTAAATACTGTTCATGGAGAATACATAGTCTAACCACTAGGCGTGTCCCTGTTATCAGCAAAGATCAATGATGCTTCATTCATGTACT
ATGTATGCATTGGTGGTAAATGGATGTGAGGGCAAGTACATCAAGTACATTCACTCTGTTTCACGTATGTGGATGCCAGTTAATTAAATG

>71723_71723_1_RAD50-CADPS_RAD50_chr5_131911620_ENST00000265335_CADPS_chr3_62578423_ENST00000283269_length(amino acids)=1003AA_BP=131
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQ
IRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTNWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQ
SEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWAIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTD
PQPGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFYADRAQKHGMDEFISS
NPCNFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVH
GNRPDGIGTVTVEEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYS
RLSEYAKIEGKKREMYEHPVFCLASQVMDLTIQNVGRLITPAKKLEDTIRLAELVIEVLQQNEEHHAEAFAWWSDLMVEHAETFLSLFAV
DMDAALEVQPPDTWDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVNNGSGTSEDLFWK
LDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEH
QYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNE
EMYIERLFDQWYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYETIRNRLTVEEATASVSEGGGLQGI

--------------------------------------------------------------
>71723_71723_2_RAD50-CADPS_RAD50_chr5_131911620_ENST00000265335_CADPS_chr3_62578423_ENST00000357948_length(transcript)=4308nt_BP=752nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTTGCTCAAGAAACAGATGTGAGAGCCCAG
ATTCGTCTGCAATTTCGTGATGTCAATGGAGAACTTATAGCTGTGCAAAGATCTATGGTGTGTACTCAGAAAAGCAAAAAGACAGAATTT
AAAACTCTGGAAGGAGTCATTACTAGAACAAACTGGGGCACCCAGGGTGACTTCTCCACAACCCATGCACTGCCAGCTGTGAAGGTGAAG
CTGTTCACAGAGAGCACAGGCGTCCTGGCGTTGGAGGACAAGGAGCTTGGGCGGGTTATTCTCCATCCCACCCCGAACAGCCCCAAACAG
TCAGAGTGGCACAAAATGACAGTCTCCAAAAACTGCCCCGACCAAGATCTCAAAATCAAACTTGCTGTCCGAATGGATAAGCCTCAAAAC
ATGAAGCATTCTGGGTATTTATGGGCCATCGGTAAGAATGTCTGGAAGAGATGGAAGAAAAGGTTTTTTGTATTGGTGCAGGTCAGTCAG
TACACGTTTGCCATGTGCAGTTATCGGGAGAAGAAAGCGGAGCCTCAGGAACTTCTACAATTGGATGGCTACACTGTGGATTACACCGAC
CCCCAGCCAGGTTTGGAGGGTGGCCGAGCCTTCTTCAATGCTGTCAAGGAGGGAGACACCGTGATATTTGCCAGTGACGATGAACAAGAC
CGCATCCTGTGGGTCCAGGCCATGTATCGGGCCACGGGGCAGTCACACAAGCCTGTGCCCCCGACCCAAGTCCAGAAACTCAACGCCAAG
GGAGGAAATGTACCTCAGCTGGATGCCCCTATCTCTCAATTTTACGCAGATAGAGCTCAAAAACATGGCATGGATGAATTTATCTCTTCC
AACCCCTGTAACTTTGACCACGCTTCCCTCTTTGAGATGGGCTGGTTCAGTCCTGGCCAGGTGTTTGTACTAGACGAGTATTGCGCCCGA
AATGGAGTCCGGGGGTGTCACCGACATCTCTGCTACCTCAGAGACTTGCTTGAACGGGCAGAAAATGGCGCCATGATCGACCCCACCCTT
CTTCACTACAGCTTTGCCTTCTGTGCATCCCATGTCCATGGGAACAGGCCTGATGGAATTGGAACTGTGACTGTTGAAGAAAAGGAACGT
TTTGAAGAAATCAAAGAGAGGCTCCGAGTTCTGCTAGAAAATCAGATTACACATTTTAGGTATTGCTTTCCATTTGGTCGACCTGAAGGT
GCTTTGAAAGCTACTCTCTCACTCTTGGAAAGGGTTTTGATGAAAGATATTGTTACCCCAGTGCCACAAGAGGAGGTAAAAACAGTTATC
CGTAAATGTCTGGAACAGGCTGCGTTAGTCAACTATTCTCGGCTCTCAGAGTATGCCAAAATCGAAGAAAATGTAGGCCGGTTAATCACT
CCTGCCAAAAAGCTTGAAGATACAATACGTCTTGCTGAACTAGTCATTGAAGTTCTTCAGCAAAATGAGGAGCACCACGCAGAGGCCTTT
GCGTGGTGGTCAGATTTAATGGTGGAGCATGCGGAGACGTTCCTGTCACTCTTTGCAGTAGACATGGATGCAGCCTTAGAGGTGCAACCT
CCAGACACATGGGACAGTTTTCCACTATTTCAGCTGCTGAATGATTTTCTCCGTACTGACTATAATTTGTGCAATGGAAAATTTCACAAA
CACCTGCAAGACCTGTTTGCCCCACTTGTTGTTAGATATGTGGATCTGATGGAGTCCTCAATTGCACAATCCATTCACAGGGGCTTTGAG
CGGGAGTCATGGGAACCAGTCAATAATGGGTCAGGCACCTCAGAAGATCTGTTTTGGAAACTTGACGCCCTTCAGACCTTCATTCGGGAC
CTGCACTGGCCTGAAGAAGAGTTTGGAAAGCACCTGGAACAACGGCTGAAGTTGATGGCAAGTGACATGATCGAATCTTGTGTCAAAAGA
ACCAGGATTGCATTTGAAGTTAAGCTGCAAAAAACCAGTCGATCAACAGATTTTCGAGTCCCACAGTCAATATGCACCATGTTTAATGTT
ATGGTTGATGCCAAAGCTCAATCAACAAAACTTTGCAGCATGGAAATGGGCCAAGAGCATCAATACCATTCAAAAATAGACGAACTAATT
GAAGAAACTGTTAAAGAAATGATAACACTCTTGGTTGCAAAGTTCGTTACTATCTTGGAAGGAGTGCTGGCAAAATTATCCAGATATGAC
GAAGGGACTTTGTTTTCTTCTTTTCTGTCATTTACCGTGAAGGCAGCTTCCAAATATGTGGATGTACCTAAACCCGGGATGGACGTGGCC
GACGCCTACGTGACTTTCGTCCGCCATTCTCAGGATGTCCTGCGTGATAAGGTCAATGAGGAGATGTACATAGAAAGGTTATTTGATCAA
TGGTACAACAGCTCCATGAACGTGATCTGCACCTGGTTGACGGACCGGATGGACTTACAGCTTCATATTTATCAGTTGAAAACACTAATT
AGGATGGTAAAGAAAACCTACAGAGATTTCCGATTGCAAGGGGTCCTGGACTCCACCTTAAACAGCAAGACCTATGAAACGATCCGGAAC
CGTCTCACTGTGGAGGAAGCCACAGCATCAGTGAGTGAAGGTGGGGGACTGCAGGGCATCAGCATGAAGGACAGCGATGAGGAAGACGAA
GAAGACGATTAGACCATTTGGTCCTAGAGTCTGCTGGGACAGAGTCCTGTAATCAGTGCATGTCCTTAGTCTGTTAGTTAAACCCATTAG
GAATTTTCTGTCAACTACCATGCCCATGAGATGTTTATCAATACAACTGCCATTTTAGCTATGTGGTACCAAGATTAGCAAATGACCTTC
ATATCCACTGATTTCCTGATGTCCATGTCTATATGTTTACAAGCAATATGGAGCACCATTCTTTAAATACTGTTCATGGAGAATACATAG
TCTAACCACTAGGCGTGTCCCTGTTATCAGCAAAGATCAATGATGCTTCATTCATGTACTATGTATGCATTGGTGGTAAATGGATGTGAG
GGCAAGTACATCAAGTACATTCACTCTGTTTCACGTATGTGGATGCCAGTTAATTAAATGAGTACGTAAATAAATTAATTAAAACACATA
GATCTGCTTTGTGTTTTTATTTTTATTTTTTGAAAAACAAAAGGCAAGTCTCCAACAATTAACTTTTGATGCTTTCTGTTCCCCTAAAAC
CAAAAAATGAACCCCTTGTGTCGTTGTTAACCCATCCTTTCATTTACTCATATAATTAGCCAAAAAAAAAAGGATGGCTACATACCAATG
GATTGATTCTCTTAATTGCCACGGCAAGGGGGCGATCCTATCATGACTTAACATCAAGCGCGCAGTTCAAAACTACTGTCTTCTGTCAAA
GTTTTCTCCTCTTAAATGTTATTTTGCTTTTACGTCTCAACTGTGTATGTAAAAAAAATGAATATTTAAATTACAACCCTAGACTAAAAA
TGTGTTTATAATAAGATGTGGATATTTCCTTCAGTAGATTGTAACCATAATTTAAATTATTTTGTTCCACACTGTTTTTTATATCTGTCA
TGTACATTGCATTTTGATCTGTAACTGCACAACCCTGGGGTTTGCTGCAGAGCTATTTCTTTCCATGTAAAGTAGTGGATCCATCTTGCT

>71723_71723_2_RAD50-CADPS_RAD50_chr5_131911620_ENST00000265335_CADPS_chr3_62578423_ENST00000357948_length(amino acids)=963AA_BP=131
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQ
IRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTNWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQ
SEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWAIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTD
PQPGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFYADRAQKHGMDEFISS
NPCNFDHASLFEMGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNRPDGIGTVTVEEKER
FEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLSEYAKIEENVGRLIT
PAKKLEDTIRLAELVIEVLQQNEEHHAEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRTDYNLCNGKFHK
HLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVNNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKR
TRIAFEVKLQKTSRSTDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYD
EGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQWYNSSMNVICTWLTDRMDLQLHIYQLKTLI

--------------------------------------------------------------
>71723_71723_3_RAD50-CADPS_RAD50_chr5_131911620_ENST00000265335_CADPS_chr3_62578423_ENST00000383710_length(transcript)=4548nt_BP=752nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTTGCTCAAGAAACAGATGTGAGAGCCCAG
ATTCGTCTGCAATTTCGTGATGTCAATGGAGAACTTATAGCTGTGCAAAGATCTATGGTGTGTACTCAGAAAAGCAAAAAGACAGAATTT
AAAACTCTGGAAGGAGTCATTACTAGAACAAACTGGGGCACCCAGGGTGACTTCTCCACAACCCATGCACTGCCAGCTGTGAAGGTGAAG
CTGTTCACAGAGAGCACAGGCGTCCTGGCGTTGGAGGACAAGGAGCTTGGGCGGGTTATTCTCCATCCCACCCCGAACAGCCCCAAACAG
TCAGAGTGGCACAAAATGACAGTCTCCAAAAACTGCCCCGACCAAGATCTCAAAATCAAACTTGCTGTCCGAATGGATAAGCCTCAAAAC
ATGAAGCATTCTGGGTATTTATGGGCCATCGGTAAGAATGTCTGGAAGAGATGGAAGAAAAGGTTTTTTGTATTGGTGCAGGTCAGTCAG
TACACGTTTGCCATGTGCAGTTATCGGGAGAAGAAAGCGGAGCCTCAGGAACTTCTACAATTGGATGGCTACACTGTGGATTACACCGAC
CCCCAGCCAGGTTTGGAGGGTGGCCGAGCCTTCTTCAATGCTGTCAAGGAGGGAGACACCGTGATATTTGCCAGTGACGATGAACAAGAC
CGCATCCTGTGGGTCCAGGCCATGTATCGGGCCACGGGGCAGTCACACAAGCCTGTGCCCCCGACCCAAGTCCAGAAACTCAACGCCAAG
GGAGGAAATGTACCTCAGCTGGATGCCCCTATCTCTCAATTTTACGCAGATAGAGCTCAAAAACATGGCATGGATGAATTTATCTCTTCC
AACCCCTGTAACTTTGACCACGCTTCCCTCTTTGAGATGGTACAACGCCTTACTTTGGATCACAGACTTAATGATTCCTATTCTTGCCTG
GGCTGGTTCAGTCCTGGCCAGGTGTTTGTACTAGACGAGTATTGCGCCCGAAATGGAGTCCGGGGGTGTCACCGACATCTCTGCTACCTC
AGAGACTTGCTTGAACGGGCAGAAAATGGCGCCATGATCGACCCCACCCTTCTTCACTACAGCTTTGCCTTCTGTGCATCCCATGTCCAT
GGGAACAGGCCTGATGGAATTGGAACTGTGACTGTTGAAGAAAAGGAACGTTTTGAAGAAATCAAAGAGAGGCTCCGAGTTCTGCTAGAA
AATCAGATTACACATTTTAGGTATTGCTTTCCATTTGGTCGACCTGAAGGTGCTTTGAAAGCTACTCTCTCACTCTTGGAAAGGGTTTTG
ATGAAAGATATTGTTACCCCAGTGCCACAAGAGGAGGTAAAAACAGTTATCCGTAAATGTCTGGAACAGGCTGCGTTAGTCAACTATTCT
CGGCTCTCAGAGTATGCCAAAATCGAAGAGAATCAAAAGGATGCAGAAAATGTAGGCCGGTTAATCACTCCTGCCAAAAAGCTTGAAGAT
ACAATACGTCTTGCTGAACTAGTCATTGAAGTTCTTCAGCAAAATGAGGAGCACCACGCAGAGCCACATGTTGATAAAGGAGAAGCCTTT
GCGTGGTGGTCAGATTTAATGGTGGAGCATGCGGAGACGTTCCTGTCACTCTTTGCAGTAGACATGGATGCAGCCTTAGAGGTGCAACCT
CCAGACACATGGGACAGTTTTCCACTATTTCAGCTGCTGAATGATTTTCTCCGTACTGACTATAATTTGTGCAATGGAAAATTTCACAAA
CACCTGCAAGACCTGTTTGCCCCACTTGTTGTTAGATATGTGGATCTGATGGAGTCCTCAATTGCACAATCCATTCACAGGGGCTTTGAG
CGGGAGTCATGGGAACCAGTCAAGAGTTTAACCAGTAACCTACCCAATGTGAACCTACCCAATGTGAACCTTCCCAAAGTACCAAATCTA
CCAGTTAACATCCCTCTAGGCATCCCACAAATGCCTACTTTTTCGGCACCGTCATGGATGGCTGCTATATATGATGCGGATAATGGGTCA
GGCACCTCAGAAGATCTGTTTTGGAAACTTGACGCCCTTCAGACCTTCATTCGGGACCTGCACTGGCCTGAAGAAGAGTTTGGAAAGCAC
CTGGAACAACGGCTGAAGTTGATGGCAAGTGACATGATCGAATCTTGTGTCAAAAGAACCAGGATTGCATTTGAAGTTAAGCTGCAAAAA
ACCAGTCGATCAACAGATTTTCGAGTCCCACAGTCAATATGCACCATGTTTAATGTTATGGTTGATGCCAAAGCTCAATCAACAAAACTT
TGCAGCATGGAAATGGGCCAAGAGCATCAATACCATTCAAAAATAGACGAACTAATTGAAGAAACTGTTAAAGAAATGATAACACTCTTG
GTTGCAAAGTTCGTTACTATCTTGGAAGGAGTGCTGGCAAAATTATCCAGATATGACGAAGGGACTTTGTTTTCTTCTTTTCTGTCATTT
ACCGTGAAGGCAGCTTCCAAATATGTGGATGTACCTAAACCCGGGATGGACGTGGCCGACGCCTACGTGACTTTCGTCCGCCATTCTCAG
GATGTCCTGCGTGATAAGGTCAATGAGGAGATGTACATAGAAAGGTTATTTGATCAATGGTACAACAGCTCCATGAACGTGATCTGCACC
TGGTTGACGGACCGGATGGACTTACAGCTTCATATTTATCAGTTGAAAACACTAATTAGGATGGTAAAGAAAACCTACAGAGATTTCCGA
TTGCAAGGGGTCCTGGACTCCACCTTAAACAGCAAGACCTATGAAACGATCCGGAACCGTCTCACTGTGGAGGAAGCCACAGCATCAGTG
AGTGAAGGTGGGGGACTGCAGGGCATCAGCATGAAGGACAGCGATGAGGAAGACGAAGAAGACGATTAGACCATTTGGTCCTAGAGTCTG
CTGGGACAGAGTCCTGTAATCAGTGCATGTCCTTAGTCTGTTAGTTAAACCCATTAGGAATTTTCTGTCAACTACCATGCCCATGAGATG
TTTATCAATACAACTGCCATTTTAGCTATGTGGTACCAAGATTAGCAAATGACCTTCATATCCACTGATTTCCTGATGTCCATGTCTATA
TGTTTACAAGCAATATGGAGCACCATTCTTTAAATACTGTTCATGGAGAATACATAGTCTAACCACTAGGCGTGTCCCTGTTATCAGCAA
AGATCAATGATGCTTCATTCATGTACTATGTATGCATTGGTGGTAAATGGATGTGAGGGCAAGTACATCAAGTACATTCACTCTGTTTCA
CGTATGTGGATGCCAGTTAATTAAATGAGTACGTAAATAAATTAATTAAAACACATAGATCTGCTTTGTGTTTTTATTTTTATTTTTTGA
AAAACAAAAGGCAAGTCTCCAACAATTAACTTTTGATGCTTTCTGTTCCCCTAAAACCAAAAAATGAACCCCTTGTGTCGTTGTTAACCC
ATCCTTTCATTTACTCATATAATTAGCCAAAAAAAAAAGGATGGCTACATACCAATGGATTGATTCTCTTAATTGCCACGGCAAGGGGGC
GATCCTATCATGACTTAACATCAAGCGCGCAGTTCAAAACTACTGTCTTCTGTCAAAGTTTTCTCCTCTTAAATGTTATTTTGCTTTTAC
GTCTCAACTGTGTATGTAAAAAAAATGAATATTTAAATTACAACCCTAGACTAAAAATGTGTTTATAATAAGATGTGGATATTTCCTTCA
GTAGATTGTAACCATAATTTAAATTATTTTGTTCCACACTGTTTTTTATATCTGTCATGTACATTGCATTTTGATCTGTAACTGCACAAC
CCTGGGGTTTGCTGCAGAGCTATTTCTTTCCATGTAAAGTAGTGGATCCATCTTGCTTTTGCCTTATATAAAGCCTACAGTTATGGAAGT

>71723_71723_3_RAD50-CADPS_RAD50_chr5_131911620_ENST00000265335_CADPS_chr3_62578423_ENST00000383710_length(amino acids)=1042AA_BP=131
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQ
IRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTNWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQ
SEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWAIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTD
PQPGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFYADRAQKHGMDEFISS
NPCNFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVH
GNRPDGIGTVTVEEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYS
RLSEYAKIEENQKDAENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHHAEPHVDKGEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQP
PDTWDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVKSLTSNLPNVNLPNVNLPKVPNL
PVNIPLGIPQMPTFSAPSWMAAIYDADNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQK
TSRSTDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLSF
TVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQWYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RAD50-CADPS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCADPSchr5:131911620chr3:62578423ENST00000283269528790_1129441.66666666666671315.0DRD2
TgeneCADPSchr5:131911620chr3:62578423ENST00000357948527790_1129441.66666666666671275.0DRD2
TgeneCADPSchr5:131911620chr3:62578423ENST00000383710530790_1129441.66666666666671354.0DRD2
TgeneCADPSchr5:131911620chr3:62578423ENST0000049035307790_11290.0458.0DRD2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAD50-CADPS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAD50-CADPS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource