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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAD50-LIPF (FusionGDB2 ID:71726)

Fusion Gene Summary for RAD50-LIPF

check button Fusion gene summary
Fusion gene informationFusion gene name: RAD50-LIPF
Fusion gene ID: 71726
HgeneTgene
Gene symbol

RAD50

LIPF

Gene ID

10111

8513

Gene nameRAD50 double strand break repair proteinlipase F, gastric type
SynonymsNBSLD|RAD502|hRad50GL|HGL|HLAL
Cytomap

5q31.1

10q23.31

Type of geneprotein-codingprotein-coding
DescriptionDNA repair protein RAD50RAD50 homolog, double strand break repair proteingastric triacylglycerol lipasegastric lipaselipase, gastric
Modification date2020032020200313
UniProtAcc.

P07098

Ensembl transtripts involved in fusion geneENST00000265335, ENST00000378823, 
ENST00000487596, 		ENST00000238983, 
ENST00000355843, ENST00000394375, 
ENST00000608620, 
Fusion gene scores* DoF score9 X 7 X 7=44117 X 18 X 7=2142
# samples 1018
** MAII scorelog2(10/441*10)=-2.1407786557828
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2142*10)=-3.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAD50 [Title/Abstract] AND LIPF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAD50(131915194)-LIPF(90429593), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAD50

GO:0000019

regulation of mitotic recombination

8756642

HgeneRAD50

GO:0006281

DNA repair

9705271

HgeneRAD50

GO:0006310

DNA recombination

9705271

HgeneRAD50

GO:0006974

cellular response to DNA damage stimulus

17500065

HgeneRAD50

GO:0007004

telomere maintenance via telomerase

9705271

HgeneRAD50

GO:0031954

positive regulation of protein autophosphorylation

15790808

HgeneRAD50

GO:0033674

positive regulation of kinase activity

15790808

HgeneRAD50

GO:1904354

negative regulation of telomere capping

17694070


check buttonFusion gene breakpoints across RAD50 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LIPF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer131NdRAD50chr5

131915194

+LIPFchr10

90429593

+


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Fusion Gene ORF analysis for RAD50-LIPF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265335ENST00000238983RAD50chr5

131915194

+LIPFchr10

90429593

+
In-frameENST00000265335ENST00000355843RAD50chr5

131915194

+LIPFchr10

90429593

+
In-frameENST00000265335ENST00000394375RAD50chr5

131915194

+LIPFchr10

90429593

+
In-frameENST00000265335ENST00000608620RAD50chr5

131915194

+LIPFchr10

90429593

+
In-frameENST00000378823ENST00000238983RAD50chr5

131915194

+LIPFchr10

90429593

+
In-frameENST00000378823ENST00000355843RAD50chr5

131915194

+LIPFchr10

90429593

+
In-frameENST00000378823ENST00000394375RAD50chr5

131915194

+LIPFchr10

90429593

+
In-frameENST00000378823ENST00000608620RAD50chr5

131915194

+LIPFchr10

90429593

+
intron-3CDSENST00000487596ENST00000238983RAD50chr5

131915194

+LIPFchr10

90429593

+
intron-3CDSENST00000487596ENST00000355843RAD50chr5

131915194

+LIPFchr10

90429593

+
intron-3CDSENST00000487596ENST00000394375RAD50chr5

131915194

+LIPFchr10

90429593

+
intron-3CDSENST00000487596ENST00000608620RAD50chr5

131915194

+LIPFchr10

90429593

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378823RAD50chr5131915194+ENST00000394375LIPFchr1090429593+18579523741726450
ENST00000378823RAD50chr5131915194+ENST00000608620LIPFchr1090429593+18579523741726450
ENST00000378823RAD50chr5131915194+ENST00000238983LIPFchr1090429593+18609523741726450
ENST00000378823RAD50chr5131915194+ENST00000355843LIPFchr1090429593+18609523741726450
ENST00000265335RAD50chr5131915194+ENST00000394375LIPFchr1090429593+18439383601712450
ENST00000265335RAD50chr5131915194+ENST00000608620LIPFchr1090429593+18439383601712450
ENST00000265335RAD50chr5131915194+ENST00000238983LIPFchr1090429593+18469383601712450
ENST00000265335RAD50chr5131915194+ENST00000355843LIPFchr1090429593+18469383601712450

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378823ENST00000394375RAD50chr5131915194+LIPFchr1090429593+0.0003581670.9996418
ENST00000378823ENST00000608620RAD50chr5131915194+LIPFchr1090429593+0.0003581670.9996418
ENST00000378823ENST00000238983RAD50chr5131915194+LIPFchr1090429593+0.0003521920.99964786
ENST00000378823ENST00000355843RAD50chr5131915194+LIPFchr1090429593+0.0003521920.99964786
ENST00000265335ENST00000394375RAD50chr5131915194+LIPFchr1090429593+0.0003542060.9996458
ENST00000265335ENST00000608620RAD50chr5131915194+LIPFchr1090429593+0.0003542060.9996458
ENST00000265335ENST00000238983RAD50chr5131915194+LIPFchr1090429593+0.0003486440.9996513
ENST00000265335ENST00000355843RAD50chr5131915194+LIPFchr1090429593+0.0003486440.9996513

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Fusion Genomic Features for RAD50-LIPF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RAD50chr5131915194+LIPFchr1090429593+0.005378830.99462116
RAD50chr5131915194+LIPFchr1090429593+0.005378830.99462116

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RAD50-LIPF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:131915194/chr10:90429593)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LIPF

P07098

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:2243091, PubMed:10358049). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (PubMed:2243091). {ECO:0000269|PubMed:10358049, ECO:0000269|PubMed:2243091}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAD50chr5:131915194chr10:90429593ENST00000265335+42536_431831313.0Nucleotide bindingATP
HgeneRAD50chr5:131915194chr10:90429593ENST00000378823+42536_43441174.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAD50chr5:131915194chr10:90429593ENST00000265335+425228_3591831313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131915194chr10:90429593ENST00000265335+425401_5981831313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131915194chr10:90429593ENST00000265335+425635_6731831313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131915194chr10:90429593ENST00000265335+425706_7341831313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131915194chr10:90429593ENST00000265335+425789_10791831313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131915194chr10:90429593ENST00000378823+425228_359441174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131915194chr10:90429593ENST00000378823+425401_598441174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131915194chr10:90429593ENST00000378823+425635_673441174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131915194chr10:90429593ENST00000378823+425706_734441174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131915194chr10:90429593ENST00000378823+425789_1079441174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131915194chr10:90429593ENST00000265335+4251201_12381831313.0Compositional biasNote=Ala/Asp-rich (DA-box)
HgeneRAD50chr5:131915194chr10:90429593ENST00000378823+4251201_1238441174.0Compositional biasNote=Ala/Asp-rich (DA-box)
HgeneRAD50chr5:131915194chr10:90429593ENST00000265335+425635_7341831313.0DomainZinc-hook
HgeneRAD50chr5:131915194chr10:90429593ENST00000378823+425635_734441174.0DomainZinc-hook
TgeneLIPFchr5:131915194chr10:90429593ENST0000023898331078_377140399.0DomainAB hydrolase-1
TgeneLIPFchr5:131915194chr10:90429593ENST0000035584341178_377117376.0DomainAB hydrolase-1
TgeneLIPFchr5:131915194chr10:90429593ENST0000039437541178_377150409.0DomainAB hydrolase-1


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Fusion Gene Sequence for RAD50-LIPF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71726_71726_1_RAD50-LIPF_RAD50_chr5_131915194_ENST00000265335_LIPF_chr10_90429593_ENST00000238983_length(transcript)=1846nt_BP=938nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTTGCTCAAGAAACAGATGTGAGAGCCCAG
ATTCGTCTGCAATTTCGTGATGTCAATGGAGAACTTATAGCTGTGCAAAGATCTATGGTGTGTACTCAGAAAAGCAAAAAGACAGAATTT
AAAACTCTGGAAGGAGTCATTACTAGAACAAAGCATGGTGAAAAGGTCAGTCTGAGCTCTAAGTGTGCAGAAATTGACCGAGAAATGATC
AGTTCTCTTGGGGTTTCCAAGGCTGTGCTAAATAATGTCATTTTCTGTCATCAAGAAGATTCTAATTGGCCTTTAAGTGAAGGAAAGGCT
TTGAAGCAAAAGTTTGATGAGATTTTTTCAGCAACAAGCTTTGATGAAATGGCTAAATATGACCTTCCAGCCACAATCGACTTCATTGTA
AAGAAAACTGGACAGAAGCAGCTACACTATGTTGGCCATTCCCAGGGCACCACCATTGGTTTTATTGCCTTTTCCACCAATCCCAGCCTG
GCTAAAAGAATCAAAACCTTCTATGCTCTAGCTCCTGTTGCCACTGTGAAGTATACAAAAAGCCTTATAAACAAACTTAGATTTGTTCCT
CAATCCCTCTTCAAGTTTATATTTGGTGACAAAATATTCTACCCACACAACTTCTTTGATCAATTTCTTGCTACTGAAGTGTGCTCCCGT
GAGATGCTGAATCTCCTTTGCAGCAATGCCTTATTTATAATTTGTGGATTTGACAGTAAGAACTTTAACACGAGTCGCTTGGATGTGTAT
CTATCACATAATCCAGCAGGAACTTCTGTTCAAAACATGTTCCATTGGACCCAGGCTGTTAAGTCTGGGAAATTCCAAGCTTATGACTGG
GGAAGCCCAGTTCAGAATAGGATGCACTATGATCAGTCCCAACCTCCCTACTACAATGTGACAGCCATGAATGTACCAATTGCAGTGTGG
AACGGTGGCAAGGACCTGTTGGCTGACCCCCAAGATGTTGGCCTTTTGCTTCCAAAACTCCCCAATCTTATTTACCACAAGGAGATTCCT
TTTTACAATCACTTGGACTTTATCTGGGCAATGGATGCCCCTCAAGAAGTTTACAATGACATTGTTTCTATGATATCAGAAGATAAAAAG
TAGTTCTGGATTTAAAGAATTATCCGTTTGTTTTTCCAAAATACTTTATTCTCTCATACATAGTATTTTCATAATGTTTGACATGCAGTG

>71726_71726_1_RAD50-LIPF_RAD50_chr5_131915194_ENST00000265335_LIPF_chr10_90429593_ENST00000238983_length(amino acids)=450AA_BP=192
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQ
IRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKA
LKQKFDEIFSATSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVP
QSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDW
GSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK

--------------------------------------------------------------
>71726_71726_2_RAD50-LIPF_RAD50_chr5_131915194_ENST00000265335_LIPF_chr10_90429593_ENST00000355843_length(transcript)=1846nt_BP=938nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTTGCTCAAGAAACAGATGTGAGAGCCCAG
ATTCGTCTGCAATTTCGTGATGTCAATGGAGAACTTATAGCTGTGCAAAGATCTATGGTGTGTACTCAGAAAAGCAAAAAGACAGAATTT
AAAACTCTGGAAGGAGTCATTACTAGAACAAAGCATGGTGAAAAGGTCAGTCTGAGCTCTAAGTGTGCAGAAATTGACCGAGAAATGATC
AGTTCTCTTGGGGTTTCCAAGGCTGTGCTAAATAATGTCATTTTCTGTCATCAAGAAGATTCTAATTGGCCTTTAAGTGAAGGAAAGGCT
TTGAAGCAAAAGTTTGATGAGATTTTTTCAGCAACAAGCTTTGATGAAATGGCTAAATATGACCTTCCAGCCACAATCGACTTCATTGTA
AAGAAAACTGGACAGAAGCAGCTACACTATGTTGGCCATTCCCAGGGCACCACCATTGGTTTTATTGCCTTTTCCACCAATCCCAGCCTG
GCTAAAAGAATCAAAACCTTCTATGCTCTAGCTCCTGTTGCCACTGTGAAGTATACAAAAAGCCTTATAAACAAACTTAGATTTGTTCCT
CAATCCCTCTTCAAGTTTATATTTGGTGACAAAATATTCTACCCACACAACTTCTTTGATCAATTTCTTGCTACTGAAGTGTGCTCCCGT
GAGATGCTGAATCTCCTTTGCAGCAATGCCTTATTTATAATTTGTGGATTTGACAGTAAGAACTTTAACACGAGTCGCTTGGATGTGTAT
CTATCACATAATCCAGCAGGAACTTCTGTTCAAAACATGTTCCATTGGACCCAGGCTGTTAAGTCTGGGAAATTCCAAGCTTATGACTGG
GGAAGCCCAGTTCAGAATAGGATGCACTATGATCAGTCCCAACCTCCCTACTACAATGTGACAGCCATGAATGTACCAATTGCAGTGTGG
AACGGTGGCAAGGACCTGTTGGCTGACCCCCAAGATGTTGGCCTTTTGCTTCCAAAACTCCCCAATCTTATTTACCACAAGGAGATTCCT
TTTTACAATCACTTGGACTTTATCTGGGCAATGGATGCCCCTCAAGAAGTTTACAATGACATTGTTTCTATGATATCAGAAGATAAAAAG
TAGTTCTGGATTTAAAGAATTATCCGTTTGTTTTTCCAAAATACTTTATTCTCTCATACATAGTATTTTCATAATGTTTGACATGCAGTG

>71726_71726_2_RAD50-LIPF_RAD50_chr5_131915194_ENST00000265335_LIPF_chr10_90429593_ENST00000355843_length(amino acids)=450AA_BP=192
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQ
IRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKA
LKQKFDEIFSATSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVP
QSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDW
GSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK

--------------------------------------------------------------
>71726_71726_3_RAD50-LIPF_RAD50_chr5_131915194_ENST00000265335_LIPF_chr10_90429593_ENST00000394375_length(transcript)=1843nt_BP=938nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTTGCTCAAGAAACAGATGTGAGAGCCCAG
ATTCGTCTGCAATTTCGTGATGTCAATGGAGAACTTATAGCTGTGCAAAGATCTATGGTGTGTACTCAGAAAAGCAAAAAGACAGAATTT
AAAACTCTGGAAGGAGTCATTACTAGAACAAAGCATGGTGAAAAGGTCAGTCTGAGCTCTAAGTGTGCAGAAATTGACCGAGAAATGATC
AGTTCTCTTGGGGTTTCCAAGGCTGTGCTAAATAATGTCATTTTCTGTCATCAAGAAGATTCTAATTGGCCTTTAAGTGAAGGAAAGGCT
TTGAAGCAAAAGTTTGATGAGATTTTTTCAGCAACAAGCTTTGATGAAATGGCTAAATATGACCTTCCAGCCACAATCGACTTCATTGTA
AAGAAAACTGGACAGAAGCAGCTACACTATGTTGGCCATTCCCAGGGCACCACCATTGGTTTTATTGCCTTTTCCACCAATCCCAGCCTG
GCTAAAAGAATCAAAACCTTCTATGCTCTAGCTCCTGTTGCCACTGTGAAGTATACAAAAAGCCTTATAAACAAACTTAGATTTGTTCCT
CAATCCCTCTTCAAGTTTATATTTGGTGACAAAATATTCTACCCACACAACTTCTTTGATCAATTTCTTGCTACTGAAGTGTGCTCCCGT
GAGATGCTGAATCTCCTTTGCAGCAATGCCTTATTTATAATTTGTGGATTTGACAGTAAGAACTTTAACACGAGTCGCTTGGATGTGTAT
CTATCACATAATCCAGCAGGAACTTCTGTTCAAAACATGTTCCATTGGACCCAGGCTGTTAAGTCTGGGAAATTCCAAGCTTATGACTGG
GGAAGCCCAGTTCAGAATAGGATGCACTATGATCAGTCCCAACCTCCCTACTACAATGTGACAGCCATGAATGTACCAATTGCAGTGTGG
AACGGTGGCAAGGACCTGTTGGCTGACCCCCAAGATGTTGGCCTTTTGCTTCCAAAACTCCCCAATCTTATTTACCACAAGGAGATTCCT
TTTTACAATCACTTGGACTTTATCTGGGCAATGGATGCCCCTCAAGAAGTTTACAATGACATTGTTTCTATGATATCAGAAGATAAAAAG
TAGTTCTGGATTTAAAGAATTATCCGTTTGTTTTTCCAAAATACTTTATTCTCTCATACATAGTATTTTCATAATGTTTGACATGCAGTG

>71726_71726_3_RAD50-LIPF_RAD50_chr5_131915194_ENST00000265335_LIPF_chr10_90429593_ENST00000394375_length(amino acids)=450AA_BP=192
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQ
IRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKA
LKQKFDEIFSATSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVP
QSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDW
GSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK

--------------------------------------------------------------
>71726_71726_4_RAD50-LIPF_RAD50_chr5_131915194_ENST00000265335_LIPF_chr10_90429593_ENST00000608620_length(transcript)=1843nt_BP=938nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTTGCTCAAGAAACAGATGTGAGAGCCCAG
ATTCGTCTGCAATTTCGTGATGTCAATGGAGAACTTATAGCTGTGCAAAGATCTATGGTGTGTACTCAGAAAAGCAAAAAGACAGAATTT
AAAACTCTGGAAGGAGTCATTACTAGAACAAAGCATGGTGAAAAGGTCAGTCTGAGCTCTAAGTGTGCAGAAATTGACCGAGAAATGATC
AGTTCTCTTGGGGTTTCCAAGGCTGTGCTAAATAATGTCATTTTCTGTCATCAAGAAGATTCTAATTGGCCTTTAAGTGAAGGAAAGGCT
TTGAAGCAAAAGTTTGATGAGATTTTTTCAGCAACAAGCTTTGATGAAATGGCTAAATATGACCTTCCAGCCACAATCGACTTCATTGTA
AAGAAAACTGGACAGAAGCAGCTACACTATGTTGGCCATTCCCAGGGCACCACCATTGGTTTTATTGCCTTTTCCACCAATCCCAGCCTG
GCTAAAAGAATCAAAACCTTCTATGCTCTAGCTCCTGTTGCCACTGTGAAGTATACAAAAAGCCTTATAAACAAACTTAGATTTGTTCCT
CAATCCCTCTTCAAGTTTATATTTGGTGACAAAATATTCTACCCACACAACTTCTTTGATCAATTTCTTGCTACTGAAGTGTGCTCCCGT
GAGATGCTGAATCTCCTTTGCAGCAATGCCTTATTTATAATTTGTGGATTTGACAGTAAGAACTTTAACACGAGTCGCTTGGATGTGTAT
CTATCACATAATCCAGCAGGAACTTCTGTTCAAAACATGTTCCATTGGACCCAGGCTGTTAAGTCTGGGAAATTCCAAGCTTATGACTGG
GGAAGCCCAGTTCAGAATAGGATGCACTATGATCAGTCCCAACCTCCCTACTACAATGTGACAGCCATGAATGTACCAATTGCAGTGTGG
AACGGTGGCAAGGACCTGTTGGCTGACCCCCAAGATGTTGGCCTTTTGCTTCCAAAACTCCCCAATCTTATTTACCACAAGGAGATTCCT
TTTTACAATCACTTGGACTTTATCTGGGCAATGGATGCCCCTCAAGAAGTTTACAATGACATTGTTTCTATGATATCAGAAGATAAAAAG
TAGTTCTGGATTTAAAGAATTATCCGTTTGTTTTTCCAAAATACTTTATTCTCTCATACATAGTATTTTCATAATGTTTGACATGCAGTG

>71726_71726_4_RAD50-LIPF_RAD50_chr5_131915194_ENST00000265335_LIPF_chr10_90429593_ENST00000608620_length(amino acids)=450AA_BP=192
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQ
IRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKA
LKQKFDEIFSATSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVP
QSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDW
GSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK

--------------------------------------------------------------
>71726_71726_5_RAD50-LIPF_RAD50_chr5_131915194_ENST00000378823_LIPF_chr10_90429593_ENST00000238983_length(transcript)=1860nt_BP=952nt
TTTCCCGGCGTGCCCCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGA
GTGCGCGGTTGCGGGGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGG
CGGGGAAAGCAGCTGGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTG
GCCTCGCTCCCCGCCCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTG
TGGGCTCCAGGTCCCTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAA
TAGAGGACAAAGATAAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTG
AATGTCTAAAATATATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTTGCTCAAGAAACAG
ATGTGAGAGCCCAGATTCGTCTGCAATTTCGTGATGTCAATGGAGAACTTATAGCTGTGCAAAGATCTATGGTGTGTACTCAGAAAAGCA
AAAAGACAGAATTTAAAACTCTGGAAGGAGTCATTACTAGAACAAAGCATGGTGAAAAGGTCAGTCTGAGCTCTAAGTGTGCAGAAATTG
ACCGAGAAATGATCAGTTCTCTTGGGGTTTCCAAGGCTGTGCTAAATAATGTCATTTTCTGTCATCAAGAAGATTCTAATTGGCCTTTAA
GTGAAGGAAAGGCTTTGAAGCAAAAGTTTGATGAGATTTTTTCAGCAACAAGCTTTGATGAAATGGCTAAATATGACCTTCCAGCCACAA
TCGACTTCATTGTAAAGAAAACTGGACAGAAGCAGCTACACTATGTTGGCCATTCCCAGGGCACCACCATTGGTTTTATTGCCTTTTCCA
CCAATCCCAGCCTGGCTAAAAGAATCAAAACCTTCTATGCTCTAGCTCCTGTTGCCACTGTGAAGTATACAAAAAGCCTTATAAACAAAC
TTAGATTTGTTCCTCAATCCCTCTTCAAGTTTATATTTGGTGACAAAATATTCTACCCACACAACTTCTTTGATCAATTTCTTGCTACTG
AAGTGTGCTCCCGTGAGATGCTGAATCTCCTTTGCAGCAATGCCTTATTTATAATTTGTGGATTTGACAGTAAGAACTTTAACACGAGTC
GCTTGGATGTGTATCTATCACATAATCCAGCAGGAACTTCTGTTCAAAACATGTTCCATTGGACCCAGGCTGTTAAGTCTGGGAAATTCC
AAGCTTATGACTGGGGAAGCCCAGTTCAGAATAGGATGCACTATGATCAGTCCCAACCTCCCTACTACAATGTGACAGCCATGAATGTAC
CAATTGCAGTGTGGAACGGTGGCAAGGACCTGTTGGCTGACCCCCAAGATGTTGGCCTTTTGCTTCCAAAACTCCCCAATCTTATTTACC
ACAAGGAGATTCCTTTTTACAATCACTTGGACTTTATCTGGGCAATGGATGCCCCTCAAGAAGTTTACAATGACATTGTTTCTATGATAT
CAGAAGATAAAAAGTAGTTCTGGATTTAAAGAATTATCCGTTTGTTTTTCCAAAATACTTTATTCTCTCATACATAGTATTTTCATAATG

>71726_71726_5_RAD50-LIPF_RAD50_chr5_131915194_ENST00000378823_LIPF_chr10_90429593_ENST00000238983_length(amino acids)=450AA_BP=192
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQ
IRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKA
LKQKFDEIFSATSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVP
QSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDW
GSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK

--------------------------------------------------------------
>71726_71726_6_RAD50-LIPF_RAD50_chr5_131915194_ENST00000378823_LIPF_chr10_90429593_ENST00000355843_length(transcript)=1860nt_BP=952nt
TTTCCCGGCGTGCCCCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGA
GTGCGCGGTTGCGGGGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGG
CGGGGAAAGCAGCTGGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTG
GCCTCGCTCCCCGCCCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTG
TGGGCTCCAGGTCCCTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAA
TAGAGGACAAAGATAAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTG
AATGTCTAAAATATATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTTGCTCAAGAAACAG
ATGTGAGAGCCCAGATTCGTCTGCAATTTCGTGATGTCAATGGAGAACTTATAGCTGTGCAAAGATCTATGGTGTGTACTCAGAAAAGCA
AAAAGACAGAATTTAAAACTCTGGAAGGAGTCATTACTAGAACAAAGCATGGTGAAAAGGTCAGTCTGAGCTCTAAGTGTGCAGAAATTG
ACCGAGAAATGATCAGTTCTCTTGGGGTTTCCAAGGCTGTGCTAAATAATGTCATTTTCTGTCATCAAGAAGATTCTAATTGGCCTTTAA
GTGAAGGAAAGGCTTTGAAGCAAAAGTTTGATGAGATTTTTTCAGCAACAAGCTTTGATGAAATGGCTAAATATGACCTTCCAGCCACAA
TCGACTTCATTGTAAAGAAAACTGGACAGAAGCAGCTACACTATGTTGGCCATTCCCAGGGCACCACCATTGGTTTTATTGCCTTTTCCA
CCAATCCCAGCCTGGCTAAAAGAATCAAAACCTTCTATGCTCTAGCTCCTGTTGCCACTGTGAAGTATACAAAAAGCCTTATAAACAAAC
TTAGATTTGTTCCTCAATCCCTCTTCAAGTTTATATTTGGTGACAAAATATTCTACCCACACAACTTCTTTGATCAATTTCTTGCTACTG
AAGTGTGCTCCCGTGAGATGCTGAATCTCCTTTGCAGCAATGCCTTATTTATAATTTGTGGATTTGACAGTAAGAACTTTAACACGAGTC
GCTTGGATGTGTATCTATCACATAATCCAGCAGGAACTTCTGTTCAAAACATGTTCCATTGGACCCAGGCTGTTAAGTCTGGGAAATTCC
AAGCTTATGACTGGGGAAGCCCAGTTCAGAATAGGATGCACTATGATCAGTCCCAACCTCCCTACTACAATGTGACAGCCATGAATGTAC
CAATTGCAGTGTGGAACGGTGGCAAGGACCTGTTGGCTGACCCCCAAGATGTTGGCCTTTTGCTTCCAAAACTCCCCAATCTTATTTACC
ACAAGGAGATTCCTTTTTACAATCACTTGGACTTTATCTGGGCAATGGATGCCCCTCAAGAAGTTTACAATGACATTGTTTCTATGATAT
CAGAAGATAAAAAGTAGTTCTGGATTTAAAGAATTATCCGTTTGTTTTTCCAAAATACTTTATTCTCTCATACATAGTATTTTCATAATG

>71726_71726_6_RAD50-LIPF_RAD50_chr5_131915194_ENST00000378823_LIPF_chr10_90429593_ENST00000355843_length(amino acids)=450AA_BP=192
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQ
IRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKA
LKQKFDEIFSATSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVP
QSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDW
GSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK

--------------------------------------------------------------
>71726_71726_7_RAD50-LIPF_RAD50_chr5_131915194_ENST00000378823_LIPF_chr10_90429593_ENST00000394375_length(transcript)=1857nt_BP=952nt
TTTCCCGGCGTGCCCCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGA
GTGCGCGGTTGCGGGGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGG
CGGGGAAAGCAGCTGGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTG
GCCTCGCTCCCCGCCCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTG
TGGGCTCCAGGTCCCTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAA
TAGAGGACAAAGATAAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTG
AATGTCTAAAATATATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTTGCTCAAGAAACAG
ATGTGAGAGCCCAGATTCGTCTGCAATTTCGTGATGTCAATGGAGAACTTATAGCTGTGCAAAGATCTATGGTGTGTACTCAGAAAAGCA
AAAAGACAGAATTTAAAACTCTGGAAGGAGTCATTACTAGAACAAAGCATGGTGAAAAGGTCAGTCTGAGCTCTAAGTGTGCAGAAATTG
ACCGAGAAATGATCAGTTCTCTTGGGGTTTCCAAGGCTGTGCTAAATAATGTCATTTTCTGTCATCAAGAAGATTCTAATTGGCCTTTAA
GTGAAGGAAAGGCTTTGAAGCAAAAGTTTGATGAGATTTTTTCAGCAACAAGCTTTGATGAAATGGCTAAATATGACCTTCCAGCCACAA
TCGACTTCATTGTAAAGAAAACTGGACAGAAGCAGCTACACTATGTTGGCCATTCCCAGGGCACCACCATTGGTTTTATTGCCTTTTCCA
CCAATCCCAGCCTGGCTAAAAGAATCAAAACCTTCTATGCTCTAGCTCCTGTTGCCACTGTGAAGTATACAAAAAGCCTTATAAACAAAC
TTAGATTTGTTCCTCAATCCCTCTTCAAGTTTATATTTGGTGACAAAATATTCTACCCACACAACTTCTTTGATCAATTTCTTGCTACTG
AAGTGTGCTCCCGTGAGATGCTGAATCTCCTTTGCAGCAATGCCTTATTTATAATTTGTGGATTTGACAGTAAGAACTTTAACACGAGTC
GCTTGGATGTGTATCTATCACATAATCCAGCAGGAACTTCTGTTCAAAACATGTTCCATTGGACCCAGGCTGTTAAGTCTGGGAAATTCC
AAGCTTATGACTGGGGAAGCCCAGTTCAGAATAGGATGCACTATGATCAGTCCCAACCTCCCTACTACAATGTGACAGCCATGAATGTAC
CAATTGCAGTGTGGAACGGTGGCAAGGACCTGTTGGCTGACCCCCAAGATGTTGGCCTTTTGCTTCCAAAACTCCCCAATCTTATTTACC
ACAAGGAGATTCCTTTTTACAATCACTTGGACTTTATCTGGGCAATGGATGCCCCTCAAGAAGTTTACAATGACATTGTTTCTATGATAT
CAGAAGATAAAAAGTAGTTCTGGATTTAAAGAATTATCCGTTTGTTTTTCCAAAATACTTTATTCTCTCATACATAGTATTTTCATAATG

>71726_71726_7_RAD50-LIPF_RAD50_chr5_131915194_ENST00000378823_LIPF_chr10_90429593_ENST00000394375_length(amino acids)=450AA_BP=192
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQ
IRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKA
LKQKFDEIFSATSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVP
QSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDW
GSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK

--------------------------------------------------------------
>71726_71726_8_RAD50-LIPF_RAD50_chr5_131915194_ENST00000378823_LIPF_chr10_90429593_ENST00000608620_length(transcript)=1857nt_BP=952nt
TTTCCCGGCGTGCCCCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGA
GTGCGCGGTTGCGGGGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGG
CGGGGAAAGCAGCTGGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTG
GCCTCGCTCCCCGCCCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTG
TGGGCTCCAGGTCCCTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAA
TAGAGGACAAAGATAAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTG
AATGTCTAAAATATATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTTGCTCAAGAAACAG
ATGTGAGAGCCCAGATTCGTCTGCAATTTCGTGATGTCAATGGAGAACTTATAGCTGTGCAAAGATCTATGGTGTGTACTCAGAAAAGCA
AAAAGACAGAATTTAAAACTCTGGAAGGAGTCATTACTAGAACAAAGCATGGTGAAAAGGTCAGTCTGAGCTCTAAGTGTGCAGAAATTG
ACCGAGAAATGATCAGTTCTCTTGGGGTTTCCAAGGCTGTGCTAAATAATGTCATTTTCTGTCATCAAGAAGATTCTAATTGGCCTTTAA
GTGAAGGAAAGGCTTTGAAGCAAAAGTTTGATGAGATTTTTTCAGCAACAAGCTTTGATGAAATGGCTAAATATGACCTTCCAGCCACAA
TCGACTTCATTGTAAAGAAAACTGGACAGAAGCAGCTACACTATGTTGGCCATTCCCAGGGCACCACCATTGGTTTTATTGCCTTTTCCA
CCAATCCCAGCCTGGCTAAAAGAATCAAAACCTTCTATGCTCTAGCTCCTGTTGCCACTGTGAAGTATACAAAAAGCCTTATAAACAAAC
TTAGATTTGTTCCTCAATCCCTCTTCAAGTTTATATTTGGTGACAAAATATTCTACCCACACAACTTCTTTGATCAATTTCTTGCTACTG
AAGTGTGCTCCCGTGAGATGCTGAATCTCCTTTGCAGCAATGCCTTATTTATAATTTGTGGATTTGACAGTAAGAACTTTAACACGAGTC
GCTTGGATGTGTATCTATCACATAATCCAGCAGGAACTTCTGTTCAAAACATGTTCCATTGGACCCAGGCTGTTAAGTCTGGGAAATTCC
AAGCTTATGACTGGGGAAGCCCAGTTCAGAATAGGATGCACTATGATCAGTCCCAACCTCCCTACTACAATGTGACAGCCATGAATGTAC
CAATTGCAGTGTGGAACGGTGGCAAGGACCTGTTGGCTGACCCCCAAGATGTTGGCCTTTTGCTTCCAAAACTCCCCAATCTTATTTACC
ACAAGGAGATTCCTTTTTACAATCACTTGGACTTTATCTGGGCAATGGATGCCCCTCAAGAAGTTTACAATGACATTGTTTCTATGATAT
CAGAAGATAAAAAGTAGTTCTGGATTTAAAGAATTATCCGTTTGTTTTTCCAAAATACTTTATTCTCTCATACATAGTATTTTCATAATG

>71726_71726_8_RAD50-LIPF_RAD50_chr5_131915194_ENST00000378823_LIPF_chr10_90429593_ENST00000608620_length(amino acids)=450AA_BP=192
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQ
IRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKA
LKQKFDEIFSATSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVP
QSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDW
GSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RAD50-LIPF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAD50-LIPF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAD50-LIPF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource