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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAD50-TCOF1 (FusionGDB2 ID:71729)

Fusion Gene Summary for RAD50-TCOF1

check button Fusion gene summary
Fusion gene informationFusion gene name: RAD50-TCOF1
Fusion gene ID: 71729
HgeneTgene
Gene symbol

RAD50

TCOF1

Gene ID

10111

6949

Gene nameRAD50 double strand break repair proteintreacle ribosome biogenesis factor 1
SynonymsNBSLD|RAD502|hRad50MFD1|TCS|TCS1|treacle
Cytomap

5q31.1

5q32-q33.1

Type of geneprotein-codingprotein-coding
DescriptionDNA repair protein RAD50RAD50 homolog, double strand break repair proteintreacle proteinTreacher Collins syndrome proteinTreacher Collins-Franceschetti syndrome 1nucleolar trafficking phosphoprotein
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265335, ENST00000378823, 
ENST00000487596, 		ENST00000394269, 
ENST00000504761, ENST00000506063, 
ENST00000513346, ENST00000323668, 
ENST00000377797, ENST00000439160, 
ENST00000445265, ENST00000451292, 
Fusion gene scores* DoF score9 X 7 X 7=44113 X 11 X 9=1287
# samples 1015
** MAII scorelog2(10/441*10)=-2.1407786557828
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1287*10)=-3.10097764772482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAD50 [Title/Abstract] AND TCOF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAD50(131895059)-TCOF1(149767465), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAD50

GO:0000019

regulation of mitotic recombination

8756642

HgeneRAD50

GO:0006281

DNA repair

9705271

HgeneRAD50

GO:0006310

DNA recombination

9705271

HgeneRAD50

GO:0006974

cellular response to DNA damage stimulus

17500065

HgeneRAD50

GO:0007004

telomere maintenance via telomerase

9705271

HgeneRAD50

GO:0031954

positive regulation of protein autophosphorylation

15790808

HgeneRAD50

GO:0033674

positive regulation of kinase activity

15790808

HgeneRAD50

GO:1904354

negative regulation of telomere capping

17694070


check buttonFusion gene breakpoints across RAD50 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TCOF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0EP-01ARAD50chr5

131895059

-TCOF1chr5

149767465

+
ChimerDB4BRCATCGA-A2-A0EP-01ARAD50chr5

131895059

+TCOF1chr5

149767465

+


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Fusion Gene ORF analysis for RAD50-TCOF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265335ENST00000394269RAD50chr5

131895059

+TCOF1chr5

149767465

+
5CDS-intronENST00000265335ENST00000504761RAD50chr5

131895059

+TCOF1chr5

149767465

+
5CDS-intronENST00000265335ENST00000506063RAD50chr5

131895059

+TCOF1chr5

149767465

+
5CDS-intronENST00000265335ENST00000513346RAD50chr5

131895059

+TCOF1chr5

149767465

+
5UTR-3CDSENST00000378823ENST00000323668RAD50chr5

131895059

+TCOF1chr5

149767465

+
5UTR-3CDSENST00000378823ENST00000377797RAD50chr5

131895059

+TCOF1chr5

149767465

+
5UTR-3CDSENST00000378823ENST00000439160RAD50chr5

131895059

+TCOF1chr5

149767465

+
5UTR-3CDSENST00000378823ENST00000445265RAD50chr5

131895059

+TCOF1chr5

149767465

+
5UTR-3CDSENST00000378823ENST00000451292RAD50chr5

131895059

+TCOF1chr5

149767465

+
5UTR-intronENST00000378823ENST00000394269RAD50chr5

131895059

+TCOF1chr5

149767465

+
5UTR-intronENST00000378823ENST00000504761RAD50chr5

131895059

+TCOF1chr5

149767465

+
5UTR-intronENST00000378823ENST00000506063RAD50chr5

131895059

+TCOF1chr5

149767465

+
5UTR-intronENST00000378823ENST00000513346RAD50chr5

131895059

+TCOF1chr5

149767465

+
In-frameENST00000265335ENST00000323668RAD50chr5

131895059

+TCOF1chr5

149767465

+
In-frameENST00000265335ENST00000377797RAD50chr5

131895059

+TCOF1chr5

149767465

+
In-frameENST00000265335ENST00000439160RAD50chr5

131895059

+TCOF1chr5

149767465

+
In-frameENST00000265335ENST00000445265RAD50chr5

131895059

+TCOF1chr5

149767465

+
In-frameENST00000265335ENST00000451292RAD50chr5

131895059

+TCOF1chr5

149767465

+
intron-3CDSENST00000487596ENST00000323668RAD50chr5

131895059

+TCOF1chr5

149767465

+
intron-3CDSENST00000487596ENST00000377797RAD50chr5

131895059

+TCOF1chr5

149767465

+
intron-3CDSENST00000487596ENST00000439160RAD50chr5

131895059

+TCOF1chr5

149767465

+
intron-3CDSENST00000487596ENST00000445265RAD50chr5

131895059

+TCOF1chr5

149767465

+
intron-3CDSENST00000487596ENST00000451292RAD50chr5

131895059

+TCOF1chr5

149767465

+
intron-intronENST00000487596ENST00000394269RAD50chr5

131895059

+TCOF1chr5

149767465

+
intron-intronENST00000487596ENST00000504761RAD50chr5

131895059

+TCOF1chr5

149767465

+
intron-intronENST00000487596ENST00000506063RAD50chr5

131895059

+TCOF1chr5

149767465

+
intron-intronENST00000487596ENST00000513346RAD50chr5

131895059

+TCOF1chr5

149767465

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265335RAD50chr5131895059+ENST00000451292TCOF1chr5149767465+27286003602207615
ENST00000265335RAD50chr5131895059+ENST00000377797TCOF1chr5149767465+27316003602210616
ENST00000265335RAD50chr5131895059+ENST00000445265TCOF1chr5149767465+27166003602210616
ENST00000265335RAD50chr5131895059+ENST00000323668TCOF1chr5149767465+27296003602207615
ENST00000265335RAD50chr5131895059+ENST00000439160TCOF1chr5149767465+23526003602096578

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265335ENST00000451292RAD50chr5131895059+TCOF1chr5149767465+0.0050965770.99490345
ENST00000265335ENST00000377797RAD50chr5131895059+TCOF1chr5149767465+0.0056824630.9943176
ENST00000265335ENST00000445265RAD50chr5131895059+TCOF1chr5149767465+0.0056013740.99439865
ENST00000265335ENST00000323668RAD50chr5131895059+TCOF1chr5149767465+0.0051583170.99484175
ENST00000265335ENST00000439160RAD50chr5131895059+TCOF1chr5149767465+0.0092163480.9907837

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Fusion Genomic Features for RAD50-TCOF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RAD50chr5131895059+TCOF1chr5149767464+0.0002112830.9997887
RAD50chr5131895059+TCOF1chr5149767464+0.0002112830.9997887

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RAD50-TCOF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:131895059/chr5:149767465)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAD50chr5:131895059chr5:149767465ENST00000265335+22536_43711313.0Nucleotide bindingATP
TgeneTCOF1chr5:131895059chr5:149767465ENST0000032366815261362_13668761517.3333333333333Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST0000032366815261452_14638761517.3333333333333Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST0000032366815261475_14828761517.3333333333333Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST000003236681526996_10018761517.3333333333333Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST0000037779716271362_13669531584.0Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST0000037779716271452_14639531584.0Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST0000037779716271475_14829531584.0Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST000003777971627996_10019531584.0Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST000003942690181362_13660959.0Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST000003942690181452_14630959.0Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST000003942690181475_14820959.0Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST00000394269018204_2070959.0Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST00000394269018693_6960959.0Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST0000039426901889_970959.0Compositional biasNote=Poly-Glu
TgeneTCOF1chr5:131895059chr5:149767465ENST00000394269018996_10010959.0Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST0000043916016261362_13669531482.6666666666667Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST0000043916016261452_14639531482.6666666666667Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST0000043916016261475_14829531482.6666666666667Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST000004391601626996_10019531482.6666666666667Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST0000044526515261362_13668761511.0Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST0000044526515261452_14638761511.0Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST0000044526515261475_14828761511.0Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST000004452651526996_10018761511.0Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST0000050476116261362_13669531489.0Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST0000050476116261452_14639531489.0Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST0000050476116261475_14829531489.0Compositional biasNote=Poly-Lys
TgeneTCOF1chr5:131895059chr5:149767465ENST000005047611626996_10019531489.0Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST000003942690186_380959.0DomainLisH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAD50chr5:131895059chr5:149767465ENST00000265335+225228_359711313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr5:149767465ENST00000265335+225401_598711313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr5:149767465ENST00000265335+225635_673711313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr5:149767465ENST00000265335+225706_734711313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr5:149767465ENST00000265335+225789_1079711313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr5:149767465ENST00000378823+225228_35901174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr5:149767465ENST00000378823+225401_59801174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr5:149767465ENST00000378823+225635_67301174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr5:149767465ENST00000378823+225706_73401174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr5:149767465ENST00000378823+225789_107901174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr5:149767465ENST00000265335+2251201_1238711313.0Compositional biasNote=Ala/Asp-rich (DA-box)
HgeneRAD50chr5:131895059chr5:149767465ENST00000378823+2251201_123801174.0Compositional biasNote=Ala/Asp-rich (DA-box)
HgeneRAD50chr5:131895059chr5:149767465ENST00000265335+225635_734711313.0DomainZinc-hook
HgeneRAD50chr5:131895059chr5:149767465ENST00000378823+225635_73401174.0DomainZinc-hook
HgeneRAD50chr5:131895059chr5:149767465ENST00000378823+22536_4301174.0Nucleotide bindingATP
TgeneTCOF1chr5:131895059chr5:149767465ENST000003236681526204_2078761517.3333333333333Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST000003236681526693_6968761517.3333333333333Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST00000323668152689_978761517.3333333333333Compositional biasNote=Poly-Glu
TgeneTCOF1chr5:131895059chr5:149767465ENST000003777971627204_2079531584.0Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST000003777971627693_6969531584.0Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST00000377797162789_979531584.0Compositional biasNote=Poly-Glu
TgeneTCOF1chr5:131895059chr5:149767465ENST000004391601626204_2079531482.6666666666667Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST000004391601626693_6969531482.6666666666667Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST00000439160162689_979531482.6666666666667Compositional biasNote=Poly-Glu
TgeneTCOF1chr5:131895059chr5:149767465ENST000004452651526204_2078761511.0Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST000004452651526693_6968761511.0Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST00000445265152689_978761511.0Compositional biasNote=Poly-Glu
TgeneTCOF1chr5:131895059chr5:149767465ENST000005047611626204_2079531489.0Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST000005047611626693_6969531489.0Compositional biasNote=Poly-Ser
TgeneTCOF1chr5:131895059chr5:149767465ENST00000504761162689_979531489.0Compositional biasNote=Poly-Glu
TgeneTCOF1chr5:131895059chr5:149767465ENST0000032366815266_388761517.3333333333333DomainLisH
TgeneTCOF1chr5:131895059chr5:149767465ENST0000037779716276_389531584.0DomainLisH
TgeneTCOF1chr5:131895059chr5:149767465ENST0000043916016266_389531482.6666666666667DomainLisH
TgeneTCOF1chr5:131895059chr5:149767465ENST0000044526515266_388761511.0DomainLisH
TgeneTCOF1chr5:131895059chr5:149767465ENST0000050476116266_389531489.0DomainLisH


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Fusion Gene Sequence for RAD50-TCOF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71729_71729_1_RAD50-TCOF1_RAD50_chr5_131895059_ENST00000265335_TCOF1_chr5_149767465_ENST00000323668_length(transcript)=2729nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGAC
CCTAATCGTAGTCCAGCTGGCCCAGCTGCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACA
GCCAGGAGCTCCTCCTCCGAGAGCGAGGATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACC
ATGCCCACTGCCCACCCAAGAATAGCCCCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAG
AAACAGGAGGGACCAGCCACTCAGGTGTCAAAGAAGAACCCAGCTTCCCTCCCACTGACCCAGGCTGCCCTGAAGGTCCTCGCCCAGAAA
GCCAGTGAGGCTCAGCCTCCTGTTGCCAGGACCCAGCCTTCAAGTGGGGTTGACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAG
AGCACCTCCGTCCAGGCCAAAGGGACCAACAAGCTCAGAAAACCTAAGCTTCCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCA
GATGACAGTGAGGACAGCAGCGACAGTTCTTCAGGGAGTGAGGAAGATGGTGAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGGT
CCCACCCCCTCCAGGACAGAGACCCTGGTGGAGGAGACCGCAGCAGAGTCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTCCTC
TCAGGTTATATGACCCCTGGACTAACCCCAGCCAATTCCCAGGCCTCAAAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCCTCT
ACTCTGGCCGCCAAAGATGACCCAGATGGCAAGCAGGAGGCAAAGCCCCAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGAAAA
GAGGCTGCTTCAGGCACCACACCTCAGAAGTCCCGGAAGCCCAAGAAAGGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAAAGC
AACATCACCCAGTGCCTCCTGGGCCAACCCTGGCCCCTGAATGAGGCCCAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTGCTG
GAACAGGAAAGAAAGAAGGTGGTGGACACCACCAAGGAGAGCAGCAGGAAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGACCAG
CCAGCTGCCAGGACCCCCAGGAGCAAGAAGAAGAAGAAGCTGGGGGCCGGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACCTCC
ACGACTTCCAAGGGGAAAGCAAAGAGAGACAAAGCAAGTGGTGATGTCAAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGGGCC
AAGGACGAGCCAGAAGAGGAGCTTCAGAAGGGGATGGGGACGGTTGAAGGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAGAAG
AAATCCGACAAGAGAAAAAAAGACAAAGAAAAAAAAGAAAAGAAGAAGAAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCGTCC
CAGAAGAAAAAGAAGAAAAAGAAGAAGACAGCAGAGCAGACTGTATGACGAGCACCAGCACCAGGCACAGGGATTTCCTAGCCGAGCAGT
GGCCATCCCCATGCCTCTGACCTCCACCGACCTCTGCCCACCATGGGTTGGAACTAAACTGTTACCTTCCCTCGCTCCACAGAAGAAGAC
AGCCAGCTTCAGGGGTCCCTGTGCTGGCCAAGCCAGTGAGCCTGCGGGGAGGCTGGTCCAAGGAGAAAGTGGACCAGCTCCCATGACCTC
ACCCCACTCCCCCAACACAGGACGCTTCATATAGATGTGTACAGTATATGTATTTTTTTAAGTGACCTCCTCTCCTTCCACAGACCCCAC
ATGCCCAAAGGCCTCGGGACTTCCCACCACCTTGCTCCACAGATCCAGCTAGGCCTGACCTGTGCCTCATCCCGTGCCGCTCGGTCTCTG
GCTGATCCCGAGGCTTTGTCTTCCTCTCGTCAGTTCTTTTGGTTGTGTTTTTTGTTTTTTTTTTAATAACTCAAAAAAAAAATAAAAGAC

>71729_71729_1_RAD50-TCOF1_RAD50_chr5_131895059_ENST00000265335_TCOF1_chr5_149767465_ENST00000323668_length(amino acids)=615AA_BP=79
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVIKPPLIFVD
PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGK
KQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESS
DDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSS
TLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELL
EQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGA

--------------------------------------------------------------
>71729_71729_2_RAD50-TCOF1_RAD50_chr5_131895059_ENST00000265335_TCOF1_chr5_149767465_ENST00000377797_length(transcript)=2731nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGAC
CCTAATCGTAGTCCAGCTGGCCCAGCTGCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACA
GCCAGGAGCTCCTCCTCCGAGAGCGAGGATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACC
ATGCCCACTGCCCACCCAAGAATAGCCCCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAG
AAACAGGAGGGACCAGCCACTCAGGTGTCAAAGAAGAACCCAGCTTCCCTCCCACTGACCCAGGCTGCCCTGAAGGTCCTCGCCCAGAAA
GCCAGTGAGGCTCAGCCTCCTGTTGCCAGGACCCAGCCTTCAAGTGGGGTTGACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAG
AGCACCTCCGTCCAGGCCAAAGGGACCAACAAGCTCAGAAAACCTAAGCTTCCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCA
GATGACAGTGAGGACAGCAGCGACAGTTCTTCAGGGAGTGAGGAAGATGGTGAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGTA
GGTCCCACCCCCTCCAGGACAGAGACCCTGGTGGAGGAGACCGCAGCAGAGTCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTC
CTCTCAGGTTATATGACCCCTGGACTAACCCCAGCCAATTCCCAGGCCTCAAAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCC
TCTACTCTGGCCGCCAAAGATGACCCAGATGGCAAGCAGGAGGCAAAGCCCCAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGA
AAAGAGGCTGCTTCAGGCACCACACCTCAGAAGTCCCGGAAGCCCAAGAAAGGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAA
AGCAACATCACCCAGTGCCTCCTGGGCCAACCCTGGCCCCTGAATGAGGCCCAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTG
CTGGAACAGGAAAGAAAGAAGGTGGTGGACACCACCAAGGAGAGCAGCAGGAAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGAC
CAGCCAGCTGCCAGGACCCCCAGGAGCAAGAAGAAGAAGAAGCTGGGGGCCGGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACC
TCCACGACTTCCAAGGGGAAAGCAAAGAGAGACAAAGCAAGTGGTGATGTCAAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGG
GCCAAGGACGAGCCAGAAGAGGAGCTTCAGAAGGGGATGGGGACGGTTGAAGGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAG
AAGAAATCCGACAAGAGAAAAAAAGACAAAGAAAAAAAAGAAAAGAAGAAGAAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCG
TCCCAGAAGAAAAAGAAGAAAAAGAAGAAGACAGCAGAGCAGACTGTATGACGAGCACCAGCACCAGGCACAGGGATTTCCTAGCCGAGC
AGTGGCCATCCCCATGCCTCTGACCTCCACCGACCTCTGCCCACCATGGGTTGGAACTAAACTGTTACCTTCCCTCGCTCCACAGAAGAA
GACAGCCAGCTTCAGGGGTCCCTGTGCTGGCCAAGCCAGTGAGCCTGCGGGGAGGCTGGTCCAAGGAGAAAGTGGACCAGCTCCCATGAC
CTCACCCCACTCCCCCAACACAGGACGCTTCATATAGATGTGTACAGTATATGTATTTTTTTAAGTGACCTCCTCTCCTTCCACAGACCC
CACATGCCCAAAGGCCTCGGGACTTCCCACCACCTTGCTCCACAGATCCAGCTAGGCCTGACCTGTGCCTCATCCCGTGCCGCTCGGTCT
CTGGCTGATCCCGAGGCTTTGTCTTCCTCTCGTCAGTTCTTTTGGTTGTGTTTTTTGTTTTTTTTTTAATAACTCAAAAAAAAAATAAAA

>71729_71729_2_RAD50-TCOF1_RAD50_chr5_131895059_ENST00000265335_TCOF1_chr5_149767465_ENST00000377797_length(amino acids)=616AA_BP=79
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVIKPPLIFVD
PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGK
KQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESS
DDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVS
STLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTEL
LEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQG

--------------------------------------------------------------
>71729_71729_3_RAD50-TCOF1_RAD50_chr5_131895059_ENST00000265335_TCOF1_chr5_149767465_ENST00000439160_length(transcript)=2352nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGAC
CCTAATCGTAGTCCAGCTGGCCCAGCTGCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACA
GCCAGGAGCTCCTCCTCCGAGAGCGAGGATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACC
ATGCCCACTGCCCACCCAAGAATAGCCCCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAG
AAACAGGAGGGACCAGCCACTCAGGTTGACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAGAGCACCTCCGTCCAGGCCAAAGGG
ACCAACAAGCTCAGAAAACCTAAGCTTCCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCAGATGACAGTGAGGACAGCAGCGAC
AGTTCTTCAGGGAGTGAGGAAGATGGTGAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGTAGGTCCCACCCCCTCCAGGACAGAG
ACCCTGGTGGAGGAGACCGCAGCAGAGTCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTCCTCTCAGGTTATATGACCCCTGGA
CTAACCCCAGCCAATTCCCAGGCCTCAAAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCCTCTACTCTGGCCGCCAAAGATGAC
CCAGATGGCAAGCAGGAGGCAAAGCCCCAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGAAAAGAGGCTGCTTCAGGCACCACA
CCTCAGAAGTCCCGGAAGCCCAAGAAAGGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAAAGCAACATCACCCAGTGCCTCCTG
GGCCAACCCTGGCCCCTGAATGAGGCCCAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTGCTGGAACAGGAAAGAAAGAAGGTG
GTGGACACCACCAAGGAGAGCAGCAGGAAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGACCAGCCAGCTGCCAGGACCCCCAGG
AGCAAGAAGAAGAAGAAGCTGGGGGCCGGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACCTCCACGACTTCCAAGGGGAAAGCA
AAGAGAGACAAAGCAAGTGGTGATGTCAAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGGGCCAAGGACGAGCCAGAAGAGGAG
CTTCAGAAGGGGATGGGGACGGTTGAAGGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAGAAGAAATCCGACAAGAGAAAAAAA
GACAAAGAAAAAAAAGAAAAGAAGAAGAAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCGTCCCAGAAGAAAAAGAAGAAAAAG
AAGAAGACAGCAGAGCAGACTGTATGACGAGCACCAGCACCAGGCACAGGGATTTCCTAGCCGAGCAGTGGCCATCCCCATGCCTCTGAC
CTCCACCGACCTCTGCCCACCATGGGTTGGAACTAAACTGTTACCTTCCCTCGCTCCACAGAAGAAGACAGCCAGCTTCAGGGGTCCCTG
TGCTGGCCAAGCCAGTGAGCCTGCGGGGAGGCTGGTCCAAGGAGAAAGTGGACCAGCTCCCATGACCTCACCCCACTCCCCCAACACAGG

>71729_71729_3_RAD50-TCOF1_RAD50_chr5_131895059_ENST00000265335_TCOF1_chr5_149767465_ENST00000439160_length(amino acids)=578AA_BP=79
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVIKPPLIFVD
PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGK
KQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTE
TLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTT
PQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPR
SKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKK

--------------------------------------------------------------
>71729_71729_4_RAD50-TCOF1_RAD50_chr5_131895059_ENST00000265335_TCOF1_chr5_149767465_ENST00000445265_length(transcript)=2716nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGAC
CCTAATCGTAGTCCAGCTGGCCCAGCTGCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACA
GCCAGGAGCTCCTCCTCCGAGAGCGAGGATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACC
ATGCCCACTGCCCACCCAAGAATAGCCCCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAG
AAACAGGAGGGACCAGCCACTCAGGTGTCAAAGAAGAACCCAGCTTCCCTCCCACTGACCCAGGCTGCCCTGAAGGTCCTCGCCCAGAAA
GCCAGTGAGGCTCAGCCTCCTGTTGCCAGGACCCAGCCTTCAAGTGGGGTTGACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAG
AGCACCTCCGTCCAGGCCAAAGGGACCAACAAGCTCAGAAAACCTAAGCTTCCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCA
GATGACAGTGAGGACAGCAGCGACAGTTCTTCAGGGAGTGAGGAAGATGGTGAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGTA
GGTCCCACCCCCTCCAGGACAGAGACCCTGGTGGAGGAGACCGCAGCAGAGTCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTC
CTCTCAGGTTATATGACCCCTGGACTAACCCCAGCCAATTCCCAGGCCTCAAAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCC
TCTACTCTGGCCGCCAAAGATGACCCAGATGGCAAGCAGGAGGCAAAGCCCCAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGA
AAAGAGGCTGCTTCAGGCACCACACCTCAGAAGTCCCGGAAGCCCAAGAAAGGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAA
AGCAACATCACCCAGTGCCTCCTGGGCCAACCCTGGCCCCTGAATGAGGCCCAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTG
CTGGAACAGGAAAGAAAGAAGGTGGTGGACACCACCAAGGAGAGCAGCAGGAAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGAC
CAGCCAGCTGCCAGGACCCCCAGGAGCAAGAAGAAGAAGAAGCTGGGGGCCGGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACC
TCCACGACTTCCAAGGGGAAAGCAAAGAGAGACAAAGCAAGTGGTGATGTCAAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGG
GCCAAGGACGAGCCAGAAGAGGAGCTTCAGAAGGGGATGGGGACGGTTGAAGGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAG
AAGAAATCCGACAAGAGAAAAAAAGACAAAGAAAAAAAAGAAAAGAAGAAGAAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCG
TCCCAGAAGAAAAAGAAGAAAAAGAAGAAGACAGCAGAGCAGACTGTATGACGAGCACCAGCACCAGGCACAGGGATTTCCTAGCCGAGC
AGTGGCCATCCCCATGCCTCTGACCTCCACCGACCTCTGCCCACCATGGGTTGGAACTAAACTGTTACCTTCCCTCGCTCCACAGAAGAA
GACAGCCAGCTTCAGGGGTCCCTGTGCTGGCCAAGCCAGTGAGCCTGCGGGGAGGCTGGTCCAAGGAGAAAGTGGACCAGCTCCCATGAC
CTCACCCCACTCCCCCAACACAGGACGCTTCATATAGATGTGTACAGTATATGTATTTTTTTAAGTGACCTCCTCTCCTTCCACAGACCC
CACATGCCCAAAGGCCTCGGGACTTCCCACCACCTTGCTCCACAGATCCAGCTAGGCCTGACCTGTGCCTCATCCCGTGCCGCTCGGTCT
CTGGCTGATCCCGAGGCTTTGTCTTCCTCTCGTCAGTTCTTTTGGTTGTGTTTTTTGTTTTTTTTTTAATAACTCAAAAAAAAAATAAAA

>71729_71729_4_RAD50-TCOF1_RAD50_chr5_131895059_ENST00000265335_TCOF1_chr5_149767465_ENST00000445265_length(amino acids)=616AA_BP=79
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVIKPPLIFVD
PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGK
KQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESS
DDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVS
STLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTEL
LEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQG

--------------------------------------------------------------
>71729_71729_5_RAD50-TCOF1_RAD50_chr5_131895059_ENST00000265335_TCOF1_chr5_149767465_ENST00000451292_length(transcript)=2728nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGAC
CCTAATCGTAGTCCAGCTGGCCCAGCTGCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACA
GCCAGGAGCTCCTCCTCCGAGAGCGAGGATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACC
ATGCCCACTGCCCACCCAAGAATAGCCCCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAG
AAACAGGAGGGACCAGCCACTCAGGTGTCAAAGAAGAACCCAGCTTCCCTCCCACTGACCCAGGCTGCCCTGAAGGTCCTCGCCCAGAAA
GCCAGTGAGGCTCAGCCTCCTGTTGCCAGGACCCAGCCTTCAAGTGGGGTTGACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAG
AGCACCTCCGTCCAGGCCAAAGGGACCAACAAGCTCAGAAAACCTAAGCTTCCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCA
GATGACAGTGAGGACAGCAGCGACAGTTCTTCAGGGAGTGAGGAAGATGGTGAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGGT
CCCACCCCCTCCAGGACAGAGACCCTGGTGGAGGAGACCGCAGCAGAGTCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTCCTC
TCAGGTTATATGACCCCTGGACTAACCCCAGCCAATTCCCAGGCCTCAAAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCCTCT
ACTCTGGCCGCCAAAGATGACCCAGATGGCAAGCAGGAGGCAAAGCCCCAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGAAAA
GAGGCTGCTTCAGGCACCACACCTCAGAAGTCCCGGAAGCCCAAGAAAGGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAAAGC
AACATCACCCAGTGCCTCCTGGGCCAACCCTGGCCCCTGAATGAGGCCCAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTGCTG
GAACAGGAAAGAAAGAAGGTGGTGGACACCACCAAGGAGAGCAGCAGGAAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGACCAG
CCAGCTGCCAGGACCCCCAGGAGCAAGAAGAAGAAGAAGCTGGGGGCCGGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACCTCC
ACGACTTCCAAGGGGAAAGCAAAGAGAGACAAAGCAAGTGGTGATGTCAAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGGGCC
AAGGACGAGCCAGAAGAGGAGCTTCAGAAGGGGATGGGGACGGTTGAAGGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAGAAG
AAATCCGACAAGAGAAAAAAAGACAAAGAAAAAAAAGAAAAGAAGAAGAAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCGTCC
CAGAAGAAAAAGAAGAAAAAGAAGAAGACAGCAGAGCAGACTGTATGACGAGCACCAGCACCAGGCACAGGGATTTCCTAGCCGAGCAGT
GGCCATCCCCATGCCTCTGACCTCCACCGACCTCTGCCCACCATGGGTTGGAACTAAACTGTTACCTTCCCTCGCTCCACAGAAGAAGAC
AGCCAGCTTCAGGGGTCCCTGTGCTGGCCAAGCCAGTGAGCCTGCGGGGAGGCTGGTCCAAGGAGAAAGTGGACCAGCTCCCATGACCTC
ACCCCACTCCCCCAACACAGGACGCTTCATATAGATGTGTACAGTATATGTATTTTTTTAAGTGACCTCCTCTCCTTCCACAGACCCCAC
ATGCCCAAAGGCCTCGGGACTTCCCACCACCTTGCTCCACAGATCCAGCTAGGCCTGACCTGTGCCTCATCCCGTGCCGCTCGGTCTCTG
GCTGATCCCGAGGCTTTGTCTTCCTCTCGTCAGTTCTTTTGGTTGTGTTTTTTGTTTTTTTTTTAATAACTCAAAAAAAAAATAAAAGAC

>71729_71729_5_RAD50-TCOF1_RAD50_chr5_131895059_ENST00000265335_TCOF1_chr5_149767465_ENST00000451292_length(amino acids)=615AA_BP=79
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVIKPPLIFVD
PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGK
KQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESS
DDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSS
TLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELL
EQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RAD50-TCOF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAD50-TCOF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAD50-TCOF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource