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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAD51B-UVRAG (FusionGDB2 ID:71761)

Fusion Gene Summary for RAD51B-UVRAG

check button Fusion gene summary
Fusion gene informationFusion gene name: RAD51B-UVRAG
Fusion gene ID: 71761
HgeneTgene
Gene symbol

RAD51B

UVRAG

Gene ID

5890

7405

Gene nameRAD51 paralog BUV radiation resistance associated
SynonymsR51H2|RAD51L1|REC2DHTX|VPS38|p63
Cytomap

14q24.1

11q13.5

Type of geneprotein-codingprotein-coding
DescriptionDNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair proteinUV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxy
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000469165, ENST00000390683, 
ENST00000471583, ENST00000487270, 
ENST00000487861, ENST00000488612, 
ENST00000356136, ENST00000528420, 
ENST00000531818, ENST00000532130, 
ENST00000533454, ENST00000539288, 
ENST00000525872, ENST00000538870, 
Fusion gene scores* DoF score22 X 15 X 11=363028 X 21 X 11=6468
# samples 2236
** MAII scorelog2(22/3630*10)=-4.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(36/6468*10)=-4.16725086714399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAD51B [Title/Abstract] AND UVRAG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUVRAG(75827059)-RAD51B(69061202), # samples:3
RAD51B(68934967)-UVRAG(75851755), # samples:2
Anticipated loss of major functional domain due to fusion event.RAD51B-UVRAG seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RAD51B-UVRAG seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RAD51B-UVRAG seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
RAD51B-UVRAG seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

TgeneUVRAG

GO:0097352

autophagosome maturation

28306502

TgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840


check buttonFusion gene breakpoints across RAD51B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UVRAG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A24Q-01ARAD51Bchr14

68934967

-UVRAGchr11

75851755

+
ChimerDB4BRCATCGA-AR-A24Q-01ARAD51Bchr14

68934967

+UVRAGchr11

75851755

+


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Fusion Gene ORF analysis for RAD51B-UVRAG

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000469165ENST00000356136RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
3UTR-3CDSENST00000469165ENST00000528420RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
3UTR-3CDSENST00000469165ENST00000531818RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
3UTR-3CDSENST00000469165ENST00000532130RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
3UTR-3CDSENST00000469165ENST00000533454RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
3UTR-3CDSENST00000469165ENST00000539288RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
3UTR-intronENST00000469165ENST00000525872RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
3UTR-intronENST00000469165ENST00000538870RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
5CDS-intronENST00000390683ENST00000525872RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
5CDS-intronENST00000390683ENST00000538870RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
5CDS-intronENST00000471583ENST00000525872RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
5CDS-intronENST00000471583ENST00000538870RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
5CDS-intronENST00000487270ENST00000525872RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
5CDS-intronENST00000487270ENST00000538870RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
5CDS-intronENST00000487861ENST00000525872RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
5CDS-intronENST00000487861ENST00000538870RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
5CDS-intronENST00000488612ENST00000525872RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
5CDS-intronENST00000488612ENST00000538870RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000390683ENST00000356136RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000390683ENST00000528420RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000390683ENST00000532130RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000390683ENST00000533454RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000390683ENST00000539288RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000471583ENST00000356136RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000471583ENST00000528420RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000471583ENST00000532130RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000471583ENST00000533454RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000471583ENST00000539288RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000487270ENST00000356136RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000487270ENST00000528420RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000487270ENST00000532130RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000487270ENST00000533454RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000487270ENST00000539288RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000487861ENST00000356136RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000487861ENST00000528420RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000487861ENST00000532130RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000487861ENST00000533454RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000487861ENST00000539288RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000488612ENST00000356136RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000488612ENST00000528420RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000488612ENST00000532130RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000488612ENST00000533454RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
Frame-shiftENST00000488612ENST00000539288RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
In-frameENST00000390683ENST00000531818RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
In-frameENST00000471583ENST00000531818RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
In-frameENST00000487270ENST00000531818RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
In-frameENST00000487861ENST00000531818RAD51Bchr14

68934967

+UVRAGchr11

75851755

+
In-frameENST00000488612ENST00000531818RAD51Bchr14

68934967

+UVRAGchr11

75851755

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000487861RAD51Bchr1468934967+ENST00000531818UVRAGchr1175851755+30541113291186385
ENST00000471583RAD51Bchr1468934967+ENST00000531818UVRAGchr1175851755+3025108401157385
ENST00000487270RAD51Bchr1468934967+ENST00000531818UVRAGchr1175851755+3025108401157385
ENST00000488612RAD51Bchr1468934967+ENST00000531818UVRAGchr1175851755+3004106301136378
ENST00000390683RAD51Bchr1468934967+ENST00000531818UVRAGchr1175851755+2977103601109369

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000487861ENST00000531818RAD51Bchr1468934967+UVRAGchr1175851755+0.0005284040.9994716
ENST00000471583ENST00000531818RAD51Bchr1468934967+UVRAGchr1175851755+0.0005246180.9994754
ENST00000487270ENST00000531818RAD51Bchr1468934967+UVRAGchr1175851755+0.0005246180.9994754
ENST00000488612ENST00000531818RAD51Bchr1468934967+UVRAGchr1175851755+0.0005757910.9994242
ENST00000390683ENST00000531818RAD51Bchr1468934967+UVRAGchr1175851755+0.0005370780.9994629

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Fusion Genomic Features for RAD51B-UVRAG


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RAD51Bchr1468934967+UVRAGchr1175851754+1.34E-060.9999987
RAD51Bchr1468934967+UVRAGchr1175851754+1.34E-060.9999987

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RAD51B-UVRAG


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:75827059/chr11:69061202)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAD51Bchr14:68934967chr11:75851755ENST00000390683+910108_115345367.0Nucleotide bindingATP
HgeneRAD51Bchr14:68934967chr11:75851755ENST00000471583+1011108_115345351.0Nucleotide bindingATP
HgeneRAD51Bchr14:68934967chr11:75851755ENST00000487270+1011108_115345385.0Nucleotide bindingATP
HgeneRAD51Bchr14:68934967chr11:75851755ENST00000488612+1012108_115345495.6666666666667Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUVRAGchr14:68934967chr11:75851755ENST000003561361315224_305465700.0Coiled coilOntology_term=ECO:0000255
TgeneUVRAGchr14:68934967chr11:75851755ENST00000356136131523_149465700.0DomainC2


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Fusion Gene Sequence for RAD51B-UVRAG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71761_71761_1_RAD51B-UVRAG_RAD51B_chr14_68934967_ENST00000390683_UVRAG_chr11_75851755_ENST00000531818_length(transcript)=2977nt_BP=1036nt
ATGGGTAGCAAGAAACTAAAACGAGTGGGTTTATCACAAGAGCTGTGTGACCGTCTGAGTAGACATCAGATCCTTACCTGTCAGGACTTT
TTATGTCTTTCCCCACTGGAGCTTATGAAGGTGACTGGTCTGAGTTATCGAGGTGTCCATGAACTTCTATGTATGGTCAGCAGGGCCTGT
GCCCCAAAGATGCAAACGGCTTATGGGATAAAAGCACAAAGGTCTGCTGATTTCTCACCAGCATTCTTATCTACTACCCTTTCTGCTTTG
GACGAAGCCCTGCATGGTGGTGTGGCTTGTGGATCCCTCACAGAGATTACAGGTCCACCAGGTTGTGGAAAAACTCAGTTTTGTATAATG
ATGAGCATTTTGGCTACATTACCCACCAACATGGGAGGATTAGAAGGAGCTGTGGTGTACATTGACACAGAGTCTGCATTTAGTGCTGAA
AGACTGGTTGAAATAGCAGAATCCCGTTTTCCCAGATATTTTAACACTGAAGAAAAGTTACTTTTGACAAGTAGTAAAGTTCATCTTTAT
CGGGAACTCACCTGTGATGAAGTTCTACAAAGGATTGAATCTTTGGAAGAAGAAATTATCTCAAAAGGAATTAAACTTGTGATTCTTGAC
TCTGTTGCTTCTGTGGTCAGAAAGGAGTTTGATGCACAACTTCAAGGCAATCTCAAAGAAAGAAACAAGTTCTTGGCAAGAGAGGCATCC
TCCTTGAAGTATTTGGCTGAGGAGTTTTCAATCCCAGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAG
GCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGG
AGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTC
ACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGAC
AAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGA
ATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCG
AGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCA
GCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCC
TACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGC
AAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTG
TGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCC
GCCGGCCGCGCAGGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGC
ACTTAACCCTTTGTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACT
CAGGATCATTGTTATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTC
TAGTTGAAAGAGCTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGAT
AATATATAAATAATATAATGAACACACCCTTAGTTTCTCATAAGCATTTGCCCTCACCATGGTTTATAAAACTTTGGGAAAACGGAATAT
TCAGAAATAGGTTTCCGCCATGTACTGAAAGGTCTGTGGCCATCTGTGAGGTAGATGAAGAAGCAGCATAGTGGTCTCCTTACATCTAGG
CCTAACTGTCCCTCTTCCTGCCCCCGGGTACCACAGTCCACCTTTAGACCCTACTGTCGCCCCATCTTCTCCGTGGATGGGCCATGCGTC
CTGAAAACAGGACATCAGATTCACTGGTTCTGTAACCCAGTAGCTGTGACGTTCCATCTCTTCTAACCAGCCATGGCCTTCCCCTCCTCT
GCCATACCCTTAATGCGGCCCTCAGATTAGATGAAAAACTTGCTCCTGGTGGATCCCAAGGGACCCTCAAGGACCTCGAGGTTACTGCAG
TCAGATGCCATCTCATCCCCTGTGGGGGCCAAAGTTTTTATGTGGGCAGATGCTGTGGTCAGGAACTAGGCATGCTTTCTGGCAATGCAC
TCACCAGACAAAAATCCCTTGATGTAAATCCCATGTTAATTTATTAAATTTCAGTCAGAAGGTCAGCATTTACATGACAGAATGTATGTA
GAGAGTTGGGGTGTCTGGTAGGCAAACTGCAAGGCAGTTGAGATAGTTGGATTAAGAGGCTAGACGAGACATAGAATACTATTGGTATGT
GTGCAATTTCATGAATATTAAATTATGTTTCGAAGTCCAGTTGTCATTCCCGCATTCAGATTTCATTTGCTGTTGCTTTATACGTTACGT
ACCCAAGGACATTGCCTCAGGGTTGCAAACTCTTTAAAGGAAAATTTATCCATATATCCATGTATTATATAGAAGAATAAAAATTGAGTT

>71761_71761_1_RAD51B-UVRAG_RAD51B_chr14_68934967_ENST00000390683_UVRAG_chr11_75851755_ENST00000531818_length(amino acids)=369AA_BP=279
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGALASQ
ADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVTDITPPVQSLFLRD

--------------------------------------------------------------
>71761_71761_2_RAD51B-UVRAG_RAD51B_chr14_68934967_ENST00000471583_UVRAG_chr11_75851755_ENST00000531818_length(transcript)=3025nt_BP=1084nt
CTGTGTAAAGGGTGGGGAAACTTGAAAGTTGGATGCTGCAGACCCGGCATGGGTAGCAAGAAACTAAAACGAGTGGGTTTATCACAAGAG
CTGTGTGACCGTCTGAGTAGACATCAGATCCTTACCTGTCAGGACTTTTTATGTCTTTCCCCACTGGAGCTTATGAAGGTGACTGGTCTG
AGTTATCGAGGTGTCCATGAACTTCTATGTATGGTCAGCAGGGCCTGTGCCCCAAAGATGCAAACGGCTTATGGGATAAAAGCACAAAGG
TCTGCTGATTTCTCACCAGCATTCTTATCTACTACCCTTTCTGCTTTGGACGAAGCCCTGCATGGTGGTGTGGCTTGTGGATCCCTCACA
GAGATTACAGGTCCACCAGGTTGTGGAAAAACTCAGTTTTGTATAATGATGAGCATTTTGGCTACATTACCCACCAACATGGGAGGATTA
GAAGGAGCTGTGGTGTACATTGACACAGAGTCTGCATTTAGTGCTGAAAGACTGGTTGAAATAGCAGAATCCCGTTTTCCCAGATATTTT
AACACTGAAGAAAAGTTACTTTTGACAAGTAGTAAAGTTCATCTTTATCGGGAACTCACCTGTGATGAAGTTCTACAAAGGATTGAATCT
TTGGAAGAAGAAATTATCTCAAAAGGAATTAAACTTGTGATTCTTGACTCTGTTGCTTCTGTGGTCAGAAAGGAGTTTGATGCACAACTT
CAAGGCAATCTCAAAGAAAGAAACAAGTTCTTGGCAAGAGAGGCATCCTCCTTGAAGTATTTGGCTGAGGAGTTTTCAATCCCAGTTATC
TTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAA
GGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGAT
TCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTT
CAAGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGG
GGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACT
CAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCT
TGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAAC
AAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAG
GCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCT
CAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAG
AGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCAGGAGTTCCGATAAGTGAAGTGAGCAGGTCA
ACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTTGTGATAATGATGACACAAAATGAATATTAA
TGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGTTATCAGTGGGCCAAAGTTAGATTTTGCTTT
CAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAGCTTACAGCTCGAGTCACCTTTTAGCTATTT
GTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATAATATAATGAACACACCCTTAGTTTCTCATA
AGCATTTGCCCTCACCATGGTTTATAAAACTTTGGGAAAACGGAATATTCAGAAATAGGTTTCCGCCATGTACTGAAAGGTCTGTGGCCA
TCTGTGAGGTAGATGAAGAAGCAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGTCCCTCTTCCTGCCCCCGGGTACCACAGTCCACC
TTTAGACCCTACTGTCGCCCCATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACAGGACATCAGATTCACTGGTTCTGTAACCCAGTA
GCTGTGACGTTCCATCTCTTCTAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCCTTAATGCGGCCCTCAGATTAGATGAAAAACTTG
CTCCTGGTGGATCCCAAGGGACCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCCATCTCATCCCCTGTGGGGGCCAAAGTTTTTATG
TGGGCAGATGCTGTGGTCAGGAACTAGGCATGCTTTCTGGCAATGCACTCACCAGACAAAAATCCCTTGATGTAAATCCCATGTTAATTT
ATTAAATTTCAGTCAGAAGGTCAGCATTTACATGACAGAATGTATGTAGAGAGTTGGGGTGTCTGGTAGGCAAACTGCAAGGCAGTTGAG
ATAGTTGGATTAAGAGGCTAGACGAGACATAGAATACTATTGGTATGTGTGCAATTTCATGAATATTAAATTATGTTTCGAAGTCCAGTT
GTCATTCCCGCATTCAGATTTCATTTGCTGTTGCTTTATACGTTACGTACCCAAGGACATTGCCTCAGGGTTGCAAACTCTTTAAAGGAA

>71761_71761_2_RAD51B-UVRAG_RAD51B_chr14_68934967_ENST00000471583_UVRAG_chr11_75851755_ENST00000531818_length(amino acids)=385AA_BP=295
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVI
LTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVL

--------------------------------------------------------------
>71761_71761_3_RAD51B-UVRAG_RAD51B_chr14_68934967_ENST00000487270_UVRAG_chr11_75851755_ENST00000531818_length(transcript)=3025nt_BP=1084nt
CTGTGTAAAGGGTGGGGAAACTTGAAAGTTGGATGCTGCAGACCCGGCATGGGTAGCAAGAAACTAAAACGAGTGGGTTTATCACAAGAG
CTGTGTGACCGTCTGAGTAGACATCAGATCCTTACCTGTCAGGACTTTTTATGTCTTTCCCCACTGGAGCTTATGAAGGTGACTGGTCTG
AGTTATCGAGGTGTCCATGAACTTCTATGTATGGTCAGCAGGGCCTGTGCCCCAAAGATGCAAACGGCTTATGGGATAAAAGCACAAAGG
TCTGCTGATTTCTCACCAGCATTCTTATCTACTACCCTTTCTGCTTTGGACGAAGCCCTGCATGGTGGTGTGGCTTGTGGATCCCTCACA
GAGATTACAGGTCCACCAGGTTGTGGAAAAACTCAGTTTTGTATAATGATGAGCATTTTGGCTACATTACCCACCAACATGGGAGGATTA
GAAGGAGCTGTGGTGTACATTGACACAGAGTCTGCATTTAGTGCTGAAAGACTGGTTGAAATAGCAGAATCCCGTTTTCCCAGATATTTT
AACACTGAAGAAAAGTTACTTTTGACAAGTAGTAAAGTTCATCTTTATCGGGAACTCACCTGTGATGAAGTTCTACAAAGGATTGAATCT
TTGGAAGAAGAAATTATCTCAAAAGGAATTAAACTTGTGATTCTTGACTCTGTTGCTTCTGTGGTCAGAAAGGAGTTTGATGCACAACTT
CAAGGCAATCTCAAAGAAAGAAACAAGTTCTTGGCAAGAGAGGCATCCTCCTTGAAGTATTTGGCTGAGGAGTTTTCAATCCCAGTTATC
TTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAA
GGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGAT
TCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTT
CAAGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGG
GGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACT
CAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCT
TGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAAC
AAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAG
GCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCT
CAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAG
AGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCAGGAGTTCCGATAAGTGAAGTGAGCAGGTCA
ACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTTGTGATAATGATGACACAAAATGAATATTAA
TGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGTTATCAGTGGGCCAAAGTTAGATTTTGCTTT
CAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAGCTTACAGCTCGAGTCACCTTTTAGCTATTT
GTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATAATATAATGAACACACCCTTAGTTTCTCATA
AGCATTTGCCCTCACCATGGTTTATAAAACTTTGGGAAAACGGAATATTCAGAAATAGGTTTCCGCCATGTACTGAAAGGTCTGTGGCCA
TCTGTGAGGTAGATGAAGAAGCAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGTCCCTCTTCCTGCCCCCGGGTACCACAGTCCACC
TTTAGACCCTACTGTCGCCCCATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACAGGACATCAGATTCACTGGTTCTGTAACCCAGTA
GCTGTGACGTTCCATCTCTTCTAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCCTTAATGCGGCCCTCAGATTAGATGAAAAACTTG
CTCCTGGTGGATCCCAAGGGACCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCCATCTCATCCCCTGTGGGGGCCAAAGTTTTTATG
TGGGCAGATGCTGTGGTCAGGAACTAGGCATGCTTTCTGGCAATGCACTCACCAGACAAAAATCCCTTGATGTAAATCCCATGTTAATTT
ATTAAATTTCAGTCAGAAGGTCAGCATTTACATGACAGAATGTATGTAGAGAGTTGGGGTGTCTGGTAGGCAAACTGCAAGGCAGTTGAG
ATAGTTGGATTAAGAGGCTAGACGAGACATAGAATACTATTGGTATGTGTGCAATTTCATGAATATTAAATTATGTTTCGAAGTCCAGTT
GTCATTCCCGCATTCAGATTTCATTTGCTGTTGCTTTATACGTTACGTACCCAAGGACATTGCCTCAGGGTTGCAAACTCTTTAAAGGAA

>71761_71761_3_RAD51B-UVRAG_RAD51B_chr14_68934967_ENST00000487270_UVRAG_chr11_75851755_ENST00000531818_length(amino acids)=385AA_BP=295
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVI
LTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVL

--------------------------------------------------------------
>71761_71761_4_RAD51B-UVRAG_RAD51B_chr14_68934967_ENST00000487861_UVRAG_chr11_75851755_ENST00000531818_length(transcript)=3054nt_BP=1113nt
GTTGCTTTGCGGCGTTTTCCGCGGGGAAACTGTGTAAAGGGTGGGGAAACTTGAAAGTTGGATGCTGCAGACCCGGCATGGGTAGCAAGA
AACTAAAACGAGTGGGTTTATCACAAGAGCTGTGTGACCGTCTGAGTAGACATCAGATCCTTACCTGTCAGGACTTTTTATGTCTTTCCC
CACTGGAGCTTATGAAGGTGACTGGTCTGAGTTATCGAGGTGTCCATGAACTTCTATGTATGGTCAGCAGGGCCTGTGCCCCAAAGATGC
AAACGGCTTATGGGATAAAAGCACAAAGGTCTGCTGATTTCTCACCAGCATTCTTATCTACTACCCTTTCTGCTTTGGACGAAGCCCTGC
ATGGTGGTGTGGCTTGTGGATCCCTCACAGAGATTACAGGTCCACCAGGTTGTGGAAAAACTCAGTTTTGTATAATGATGAGCATTTTGG
CTACATTACCCACCAACATGGGAGGATTAGAAGGAGCTGTGGTGTACATTGACACAGAGTCTGCATTTAGTGCTGAAAGACTGGTTGAAA
TAGCAGAATCCCGTTTTCCCAGATATTTTAACACTGAAGAAAAGTTACTTTTGACAAGTAGTAAAGTTCATCTTTATCGGGAACTCACCT
GTGATGAAGTTCTACAAAGGATTGAATCTTTGGAAGAAGAAATTATCTCAAAAGGAATTAAACTTGTGATTCTTGACTCTGTTGCTTCTG
TGGTCAGAAAGGAGTTTGATGCACAACTTCAAGGCAATCTCAAAGAAAGAAACAAGTTCTTGGCAAGAGAGGCATCCTCCTTGAAGTATT
TGGCTGAGGAGTTTTCAATCCCAGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGT
CTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGA
ATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCT
ACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATT
TGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCA
GTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAAC
ATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGG
CCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCA
GGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAAT
CATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTG
TGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCAG
GAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTTG
TGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGTT
ATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAGC
TTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATAA
TATAATGAACACACCCTTAGTTTCTCATAAGCATTTGCCCTCACCATGGTTTATAAAACTTTGGGAAAACGGAATATTCAGAAATAGGTT
TCCGCCATGTACTGAAAGGTCTGTGGCCATCTGTGAGGTAGATGAAGAAGCAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGTCCCT
CTTCCTGCCCCCGGGTACCACAGTCCACCTTTAGACCCTACTGTCGCCCCATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACAGGAC
ATCAGATTCACTGGTTCTGTAACCCAGTAGCTGTGACGTTCCATCTCTTCTAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCCTTAA
TGCGGCCCTCAGATTAGATGAAAAACTTGCTCCTGGTGGATCCCAAGGGACCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCCATCT
CATCCCCTGTGGGGGCCAAAGTTTTTATGTGGGCAGATGCTGTGGTCAGGAACTAGGCATGCTTTCTGGCAATGCACTCACCAGACAAAA
ATCCCTTGATGTAAATCCCATGTTAATTTATTAAATTTCAGTCAGAAGGTCAGCATTTACATGACAGAATGTATGTAGAGAGTTGGGGTG
TCTGGTAGGCAAACTGCAAGGCAGTTGAGATAGTTGGATTAAGAGGCTAGACGAGACATAGAATACTATTGGTATGTGTGCAATTTCATG
AATATTAAATTATGTTTCGAAGTCCAGTTGTCATTCCCGCATTCAGATTTCATTTGCTGTTGCTTTATACGTTACGTACCCAAGGACATT

>71761_71761_4_RAD51B-UVRAG_RAD51B_chr14_68934967_ENST00000487861_UVRAG_chr11_75851755_ENST00000531818_length(amino acids)=385AA_BP=295
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVI
LTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVL

--------------------------------------------------------------
>71761_71761_5_RAD51B-UVRAG_RAD51B_chr14_68934967_ENST00000488612_UVRAG_chr11_75851755_ENST00000531818_length(transcript)=3004nt_BP=1063nt
TTGAAAGTTGGATGCTGCAGACCCGGCATGGGTAGCAAGAAACTAAAACGAGTGGGTTTATCACAAGAGCTGTGTGACCGTCTGAGTAGA
CATCAGATCCTTACCTGTCAGGACTTTTTATGTCTTTCCCCACTGGAGCTTATGAAGGTGACTGGTCTGAGTTATCGAGGTGTCCATGAA
CTTCTATGTATGGTCAGCAGGGCCTGTGCCCCAAAGATGCAAACGGCTTATGGGATAAAAGCACAAAGGTCTGCTGATTTCTCACCAGCA
TTCTTATCTACTACCCTTTCTGCTTTGGACGAAGCCCTGCATGGTGGTGTGGCTTGTGGATCCCTCACAGAGATTACAGGTCCACCAGGT
TGTGGAAAAACTCAGTTTTGTATAATGATGAGCATTTTGGCTACATTACCCACCAACATGGGAGGATTAGAAGGAGCTGTGGTGTACATT
GACACAGAGTCTGCATTTAGTGCTGAAAGACTGGTTGAAATAGCAGAATCCCGTTTTCCCAGATATTTTAACACTGAAGAAAAGTTACTT
TTGACAAGTAGTAAAGTTCATCTTTATCGGGAACTCACCTGTGATGAAGTTCTACAAAGGATTGAATCTTTGGAAGAAGAAATTATCTCA
AAAGGAATTAAACTTGTGATTCTTGACTCTGTTGCTTCTGTGGTCAGAAAGGAGTTTGATGCACAACTTCAAGGCAATCTCAAAGAAAGA
AACAAGTTCTTGGCAAGAGAGGCATCCTCCTTGAAGTATTTGGCTGAGGAGTTTTCAATCCCAGTTATCTTGACGAATCAGATTACAACC
CATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGT
GTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTT
ATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGTGACAGACATCACACCT
CCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAG
GACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGA
CCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACA
AGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGC
ACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAG
AAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCAT
TTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATG
CACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCAGGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAG
CTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTTGTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAA
ACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGTTATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCT
GATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAGCTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTT
GTATGTTATCCTCAGAGGGAAGATGATAATATATAAATAATATAATGAACACACCCTTAGTTTCTCATAAGCATTTGCCCTCACCATGGT
TTATAAAACTTTGGGAAAACGGAATATTCAGAAATAGGTTTCCGCCATGTACTGAAAGGTCTGTGGCCATCTGTGAGGTAGATGAAGAAG
CAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGTCCCTCTTCCTGCCCCCGGGTACCACAGTCCACCTTTAGACCCTACTGTCGCCCC
ATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACAGGACATCAGATTCACTGGTTCTGTAACCCAGTAGCTGTGACGTTCCATCTCTTC
TAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCCTTAATGCGGCCCTCAGATTAGATGAAAAACTTGCTCCTGGTGGATCCCAAGGGA
CCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCCATCTCATCCCCTGTGGGGGCCAAAGTTTTTATGTGGGCAGATGCTGTGGTCAGG
AACTAGGCATGCTTTCTGGCAATGCACTCACCAGACAAAAATCCCTTGATGTAAATCCCATGTTAATTTATTAAATTTCAGTCAGAAGGT
CAGCATTTACATGACAGAATGTATGTAGAGAGTTGGGGTGTCTGGTAGGCAAACTGCAAGGCAGTTGAGATAGTTGGATTAAGAGGCTAG
ACGAGACATAGAATACTATTGGTATGTGTGCAATTTCATGAATATTAAATTATGTTTCGAAGTCCAGTTGTCATTCCCGCATTCAGATTT
CATTTGCTGTTGCTTTATACGTTACGTACCCAAGGACATTGCCTCAGGGTTGCAAACTCTTTAAAGGAAAATTTATCCATATATCCATGT

>71761_71761_5_RAD51B-UVRAG_RAD51B_chr14_68934967_ENST00000488612_UVRAG_chr11_75851755_ENST00000531818_length(amino acids)=378AA_BP=288
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITT
HLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVTDITP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RAD51B-UVRAG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneRAD51Bchr14:68934967chr11:75851755ENST00000390683+9101_75345.3333333333333367.0RAD51C
HgeneRAD51Bchr14:68934967chr11:75851755ENST00000471583+10111_75345.3333333333333351.0RAD51C
HgeneRAD51Bchr14:68934967chr11:75851755ENST00000487270+10111_75345.3333333333333385.0RAD51C
HgeneRAD51Bchr14:68934967chr11:75851755ENST00000488612+10121_75345.3333333333333495.6666666666667RAD51C


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAD51B-UVRAG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAD51B-UVRAG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource