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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAD51D-MAP2K4 (FusionGDB2 ID:71769)

Fusion Gene Summary for RAD51D-MAP2K4

check button Fusion gene summary
Fusion gene informationFusion gene name: RAD51D-MAP2K4
Fusion gene ID: 71769
HgeneTgene
Gene symbol

RAD51D

MAP2K4

Gene ID

5892

6416

Gene nameRAD51 paralog Dmitogen-activated protein kinase kinase 4
SynonymsBROVCA4|R51H3|RAD51L3|TRADJNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1
Cytomap

17q12

17p12

Type of geneprotein-codingprotein-coding
DescriptionDNA repair protein RAD51 homolog 4RAD51 homolog DRAD51-like protein 3recombination repair proteindual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1
Modification date2020031320200329
UniProtAcc.

P45985

Ensembl transtripts involved in fusion geneENST00000335858, ENST00000345365, 
ENST00000360276, ENST00000394589, 
ENST00000460118, ENST00000590016, 
ENST00000590380, ENST00000357906, 
ENST00000581941, ENST00000353533, 
ENST00000415385, 
Fusion gene scores* DoF score4 X 3 X 4=488 X 10 X 6=480
# samples 410
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAD51D [Title/Abstract] AND MAP2K4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAD51D(33428220)-MAP2K4(11984673), # samples:2
Anticipated loss of major functional domain due to fusion event.RAD51D-MAP2K4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RAD51D-MAP2K4 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
RAD51D-MAP2K4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RAD51D-MAP2K4 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
RAD51D-MAP2K4 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAD51D

GO:0042148

strand invasion

11834724


check buttonFusion gene breakpoints across RAD51D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAP2K4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-3U-A98I-01ARAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
ChimerDB4MESOTCGA-3U-A98IRAD51Dchr17

33428220

-MAP2K4chr17

11984673

+


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Fusion Gene ORF analysis for RAD51D-MAP2K4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000335858ENST00000581941RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
5CDS-3UTRENST00000345365ENST00000581941RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
5CDS-3UTRENST00000360276ENST00000581941RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
5CDS-3UTRENST00000394589ENST00000581941RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
5CDS-3UTRENST00000460118ENST00000581941RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
5CDS-3UTRENST00000590016ENST00000581941RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
5UTR-3CDSENST00000590380ENST00000353533RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
5UTR-3CDSENST00000590380ENST00000415385RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
5UTR-3UTRENST00000590380ENST00000581941RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
Frame-shiftENST00000335858ENST00000353533RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
Frame-shiftENST00000335858ENST00000415385RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
Frame-shiftENST00000345365ENST00000353533RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
Frame-shiftENST00000345365ENST00000415385RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
Frame-shiftENST00000360276ENST00000353533RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
Frame-shiftENST00000360276ENST00000415385RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
Frame-shiftENST00000460118ENST00000353533RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
Frame-shiftENST00000460118ENST00000415385RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
Frame-shiftENST00000590016ENST00000353533RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
Frame-shiftENST00000590016ENST00000415385RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
In-frameENST00000394589ENST00000353533RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
In-frameENST00000394589ENST00000415385RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
intron-3CDSENST00000357906ENST00000353533RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
intron-3CDSENST00000357906ENST00000415385RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+
intron-3UTRENST00000357906ENST00000581941RAD51Dchr17

33428220

-MAP2K4chr17

11984673

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000394589RAD51Dchr1733428220-ENST00000353533MAP2K4chr1711984673+458710429232023366
ENST00000394589RAD51Dchr1733428220-ENST00000415385MAP2K4chr1711984673+459410429232023366

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394589ENST00000353533RAD51Dchr1733428220-MAP2K4chr1711984673+0.0013691760.9986308
ENST00000394589ENST00000415385RAD51Dchr1733428220-MAP2K4chr1711984673+0.0013609030.99863905

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Fusion Genomic Features for RAD51D-MAP2K4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RAD51Dchr1733428219-MAP2K4chr1711984672+0.0004188690.99958116
RAD51Dchr1733428219-MAP2K4chr1711984672+0.0004188690.99958116
RAD51Dchr1733428219-MAP2K4chr1711984672+0.0004188690.99958116
RAD51Dchr1733428219-MAP2K4chr1711984672+0.0004188690.99958116

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RAD51D-MAP2K4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:33428220/chr17:11984673)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAP2K4

P45985

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000345365-910200_205301329.0Compositional biasNote=Poly-Val
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000360276-89200_205256284.0Compositional biasNote=Poly-Val
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000394589-1011200_205301329.0Compositional biasNote=Poly-Val
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000590016-910200_205321349.0Compositional biasNote=Poly-Val
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000335858-67107_114189217.0Nucleotide bindingATP
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000345365-910107_114301329.0Nucleotide bindingATP
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000360276-89107_114256284.0Nucleotide bindingATP
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000394589-1011107_114301329.0Nucleotide bindingATP
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000590016-910107_114321349.0Nucleotide bindingATP
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000335858-671_83189217.0RegionNote=preferentially binds ssDNA
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000345365-9101_83301329.0RegionNote=preferentially binds ssDNA
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000360276-891_83256284.0RegionNote=preferentially binds ssDNA
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000394589-10111_83301329.0RegionNote=preferentially binds ssDNA
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000590016-9101_83321349.0RegionNote=preferentially binds ssDNA
TgeneMAP2K4chr17:33428220chr17:11984673ENST00000353533111102_36772400.0DomainProtein kinase
TgeneMAP2K4chr17:33428220chr17:11984673ENST00000415385212102_36783411.0DomainProtein kinase
TgeneMAP2K4chr17:33428220chr17:11984673ENST00000353533111108_11672400.0Nucleotide bindingATP
TgeneMAP2K4chr17:33428220chr17:11984673ENST00000415385212108_11683411.0Nucleotide bindingATP
TgeneMAP2K4chr17:33428220chr17:11984673ENST00000353533111364_38772400.0RegionNote=DVD domain
TgeneMAP2K4chr17:33428220chr17:11984673ENST00000415385212364_38783411.0RegionNote=DVD domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000335858-67200_205189217.0Compositional biasNote=Poly-Val
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000357906-14200_2050119.0Compositional biasNote=Poly-Val
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000357906-14107_1140119.0Nucleotide bindingATP
HgeneRAD51Dchr17:33428220chr17:11984673ENST00000357906-141_830119.0RegionNote=preferentially binds ssDNA
TgeneMAP2K4chr17:33428220chr17:11984673ENST000003535331115_1972400.0Compositional biasNote=Gly/Ser-rich
TgeneMAP2K4chr17:33428220chr17:11984673ENST000004153852125_1983411.0Compositional biasNote=Gly/Ser-rich
TgeneMAP2K4chr17:33428220chr17:11984673ENST0000035353311137_5272400.0RegionNote=D domain
TgeneMAP2K4chr17:33428220chr17:11984673ENST0000041538521237_5283411.0RegionNote=D domain


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Fusion Gene Sequence for RAD51D-MAP2K4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71769_71769_1_RAD51D-MAP2K4_RAD51D_chr17_33428220_ENST00000394589_MAP2K4_chr17_11984673_ENST00000353533_length(transcript)=4587nt_BP=1042nt
CGGTGTGTGTGTTGCGGCAGAAGCCAGCGCGCCTGTGTCCTCTCTAGGAAGGGGTAGGGGAGGGGCGTCTGGAGAGGACCCCCCGCGAAT
GCCCACGTGACGTGCAGTCCCCCTGGGGCTGTTCCGGCCTGCGGGGAACATGGGCGTGCTCAGGGTCGGACTGTGCCCTGGCCTTACCGA
GGAGATGATCCAGCTTCTCAGGAGCCACAGGATCAAGACAGTGGTGGACCTGGTTTCTGCAGACCTGGAAGAGGTAGCTCAGAAATGTGG
CTTGTCTTACAAGGCCCTGGTTGCCCTGAGGCGGGTGCTGCTGGCTCAGTTCTCGGCTTTCCCCGTGAATGGCGCTGATCTCTACGAGGA
ACTGAAGACCTCCACTGCCATCCTGTCCACTGGCATTGGCAGTCTTGATAAACTGCTTGATGCTGGTCTCTATACTGGAGAAGTGACTGA
AATTGTAGGAGGCCCAGGTAGCGGCAAAACTCAGGTATGTCTCTGTATGGCAGCAAATGTGGCCCATGGCCTGCAGCAAAACGTCCTATA
TGTAGATTCCAATGGAGGGCTGACAGCTTCCCGCCTCCTCCAGCTGCTTCAGGCTAAAACCCAGGATGAGGAGGAACAGGCAGAAGCTCT
CCGGAGGATCCAGGTGGTGCATGCATTTGACATCTTCCAGATGCTGGATGTGCTGCAGGAGCTCCGAGGCACTGTGGCCCAGCAGGTGAC
TGGTTCTTCAGGAACTGTGAAGGTGGTGGTTGTGGACTCGGTCACTGCGGTGGTTTCCCCACTTCTGGGAGGTCAGCAGAGGGAAGGCTT
GGCCTTGATGATGCAGCTGGCCCGAGAGCTGAAGACCCTGGCCCGGGACCTTGGCATGGCAGTGGTGGTGACCAACCACATAACTCGAGA
CAGGGACAGCGGGAGGCTCAAACCTGCCCTCGGACGCTCCTGGAGCTTTGTGCCCAGCACTCGGATTCTCCTGGACACCATCGAGGGAGC
AGGAGCATCAGGCGGCCGGCGCATGGCGTGTCTGGCCAAATCTTCCCGACAGAGAGAGACTGAGAACACACAGCATTGAGTCATCAGGAA
AACTGAAGATCTCCCCTGAACAACACTGGGATTTCACTGCAGAGGACTTGAAAGACCTTGGAGAAATTGGACGAGGAGCTTATGGTTCTG
TCAACAAAATGGTCCACAAACCAAGTGGGCAAATAATGGCAGTTAAAAGAATTCGGTCAACAGTGGATGAAAAAGAACAAAAACAACTTC
TTATGGATTTGGATGTAGTAATGCGGAGTAGTGATTGCCCATACATTGTTCAGTTTTATGGTGCACTCTTCAGAGAGGGTGACTGTTGGA
TCTGTATGGAACTCATGTCTACCTCGTTTGATAAGTTTTACAAATATGTATATAGTGTATTAGATGATGTTATTCCAGAAGAAATTTTAG
GCAAAATCACTTTAGCAACTGTGAAAGCACTAAACCACTTAAAAGAAAACTTGAAAATTATTCACAGAGATATCAAACCTTCCAATATTC
TTCTGGACAGAAGTGGAAATATTAAGCTCTGTGACTTCGGCATCAGTGGACAGCTTGTGGACTCTATTGCCAAGACAAGAGATGCTGGCT
GTAGGCCATACATGGCACCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCA
CATTGTATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTC
CGCAGCTGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGC
CAAAGTATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGG
ATCAAATGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTACATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCA
AGACGTAAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACCATGTGCAATAAGATTGGTGTTCGTTTCCATCATG
TCTGTATACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGC
TCTTTTGTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGACTGTGATTAGATCACATCTTAAATTCATTTCTAG
ACTCAAAACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCCTGGAAGGACACAGTGATGAATGTACTATGTCTGA
ACATAGAAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTGGGAGACAAAGGAGGAATTTACT
TTCTTCACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGTTTGGGGATCGATGTGCTCAGCCAAAT
TTCCTGTTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCATGTTGCGTTCAAAGAGGTGAACATTAAAATATAGA
GACAGGACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGACTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTG
ATCCTAAGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACA
GTACAGAAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAACTTGTAGCAGCTATATATTTCCCCTTGGTCCCAAG
CCTGATACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGTGCCTTGATTGATTAGATAAAGATTTCTAGTAGGC
AGCAAAAGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCAGTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTA
TTGTCGCTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAAAACCTTTACAGTTAGCAGGGATGTTCCTTACCAA
GGATTTTTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGTGGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGC
ATCTTTTCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGTTCATCACCTGCTAGAACCTCTCGTAGTCCATCAC
CATTTCTTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCCTCAGCACTGTTACAAGAGGCCATTTAAGTATCTT
GTGCTTCTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCCTGGCACTGAACCTTAGGCTTTGTATGACAGTGAA
GCAGCACTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGATGCAGGTGATGCCATTACAGAACCAAATCGTGGCA
CGTATTGCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAGGGAGAATGGTGCTGTTTAAAGTCACATCCCTGTA
AATTGCAGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATCTTCTCCCCCACGGTATCCTAAACTTTAGACTTCC
CACTGTTCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATCATCCTCCATTGCTCCCGGGGACTCAAGAGGAATC
TGTTTCTCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTATGCAAATGGAGATAAAAGCAATTCTGACTGTCCAG
GAGCTAATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTGTATTAATCATAGATTATTATAAACTATAAACTTA
AGGGCAAGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTTCACAAACTGTGAAAATAGTGTAAGAACTGTACAT
TGTGAGCTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAAAAAGCTAATGTGCAGGGATATTGCCTTATTTGTC
TGTAAAAAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTATCCTGTATTCTTGTTTGAATTCCTCCTCTATTTAA
GATATATACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGGTCAGTTGTAATAAATCTAGGATGTGATGATGACT

>71769_71769_1_RAD51D-MAP2K4_RAD51D_chr17_33428220_ENST00000394589_MAP2K4_chr17_11984673_ENST00000353533_length(amino acids)=366AA_BP=39
MPSDAPGALCPALGFSWTPSREQEHQAAGAWRVWPNLPDRERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKP
SGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATV
KALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATG
RFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPS

--------------------------------------------------------------
>71769_71769_2_RAD51D-MAP2K4_RAD51D_chr17_33428220_ENST00000394589_MAP2K4_chr17_11984673_ENST00000415385_length(transcript)=4594nt_BP=1042nt
CGGTGTGTGTGTTGCGGCAGAAGCCAGCGCGCCTGTGTCCTCTCTAGGAAGGGGTAGGGGAGGGGCGTCTGGAGAGGACCCCCCGCGAAT
GCCCACGTGACGTGCAGTCCCCCTGGGGCTGTTCCGGCCTGCGGGGAACATGGGCGTGCTCAGGGTCGGACTGTGCCCTGGCCTTACCGA
GGAGATGATCCAGCTTCTCAGGAGCCACAGGATCAAGACAGTGGTGGACCTGGTTTCTGCAGACCTGGAAGAGGTAGCTCAGAAATGTGG
CTTGTCTTACAAGGCCCTGGTTGCCCTGAGGCGGGTGCTGCTGGCTCAGTTCTCGGCTTTCCCCGTGAATGGCGCTGATCTCTACGAGGA
ACTGAAGACCTCCACTGCCATCCTGTCCACTGGCATTGGCAGTCTTGATAAACTGCTTGATGCTGGTCTCTATACTGGAGAAGTGACTGA
AATTGTAGGAGGCCCAGGTAGCGGCAAAACTCAGGTATGTCTCTGTATGGCAGCAAATGTGGCCCATGGCCTGCAGCAAAACGTCCTATA
TGTAGATTCCAATGGAGGGCTGACAGCTTCCCGCCTCCTCCAGCTGCTTCAGGCTAAAACCCAGGATGAGGAGGAACAGGCAGAAGCTCT
CCGGAGGATCCAGGTGGTGCATGCATTTGACATCTTCCAGATGCTGGATGTGCTGCAGGAGCTCCGAGGCACTGTGGCCCAGCAGGTGAC
TGGTTCTTCAGGAACTGTGAAGGTGGTGGTTGTGGACTCGGTCACTGCGGTGGTTTCCCCACTTCTGGGAGGTCAGCAGAGGGAAGGCTT
GGCCTTGATGATGCAGCTGGCCCGAGAGCTGAAGACCCTGGCCCGGGACCTTGGCATGGCAGTGGTGGTGACCAACCACATAACTCGAGA
CAGGGACAGCGGGAGGCTCAAACCTGCCCTCGGACGCTCCTGGAGCTTTGTGCCCAGCACTCGGATTCTCCTGGACACCATCGAGGGAGC
AGGAGCATCAGGCGGCCGGCGCATGGCGTGTCTGGCCAAATCTTCCCGACAGAGAGAGACTGAGAACACACAGCATTGAGTCATCAGGAA
AACTGAAGATCTCCCCTGAACAACACTGGGATTTCACTGCAGAGGACTTGAAAGACCTTGGAGAAATTGGACGAGGAGCTTATGGTTCTG
TCAACAAAATGGTCCACAAACCAAGTGGGCAAATAATGGCAGTTAAAAGAATTCGGTCAACAGTGGATGAAAAAGAACAAAAACAACTTC
TTATGGATTTGGATGTAGTAATGCGGAGTAGTGATTGCCCATACATTGTTCAGTTTTATGGTGCACTCTTCAGAGAGGGTGACTGTTGGA
TCTGTATGGAACTCATGTCTACCTCGTTTGATAAGTTTTACAAATATGTATATAGTGTATTAGATGATGTTATTCCAGAAGAAATTTTAG
GCAAAATCACTTTAGCAACTGTGAAAGCACTAAACCACTTAAAAGAAAACTTGAAAATTATTCACAGAGATATCAAACCTTCCAATATTC
TTCTGGACAGAAGTGGAAATATTAAGCTCTGTGACTTCGGCATCAGTGGACAGCTTGTGGACTCTATTGCCAAGACAAGAGATGCTGGCT
GTAGGCCATACATGGCACCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCA
CATTGTATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTC
CGCAGCTGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGC
CAAAGTATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGG
ATCAAATGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTACATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCA
AGACGTAAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACCATGTGCAATAAGATTGGTGTTCGTTTCCATCATG
TCTGTATACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGC
TCTTTTGTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGACTGTGATTAGATCACATCTTAAATTCATTTCTAG
ACTCAAAACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCCTGGAAGGACACAGTGATGAATGTACTATGTCTGA
ACATAGAAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTGGGAGACAAAGGAGGAATTTACT
TTCTTCACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGTTTGGGGATCGATGTGCTCAGCCAAAT
TTCCTGTTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCATGTTGCGTTCAAAGAGGTGAACATTAAAATATAGA
GACAGGACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGACTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTG
ATCCTAAGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACA
GTACAGAAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAACTTGTAGCAGCTATATATTTCCCCTTGGTCCCAAG
CCTGATACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGTGCCTTGATTGATTAGATAAAGATTTCTAGTAGGC
AGCAAAAGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCAGTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTA
TTGTCGCTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAAAACCTTTACAGTTAGCAGGGATGTTCCTTACCAA
GGATTTTTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGTGGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGC
ATCTTTTCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGTTCATCACCTGCTAGAACCTCTCGTAGTCCATCAC
CATTTCTTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCCTCAGCACTGTTACAAGAGGCCATTTAAGTATCTT
GTGCTTCTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCCTGGCACTGAACCTTAGGCTTTGTATGACAGTGAA
GCAGCACTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGATGCAGGTGATGCCATTACAGAACCAAATCGTGGCA
CGTATTGCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAGGGAGAATGGTGCTGTTTAAAGTCACATCCCTGTA
AATTGCAGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATCTTCTCCCCCACGGTATCCTAAACTTTAGACTTCC
CACTGTTCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATCATCCTCCATTGCTCCCGGGGACTCAAGAGGAATC
TGTTTCTCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTATGCAAATGGAGATAAAAGCAATTCTGACTGTCCAG
GAGCTAATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTGTATTAATCATAGATTATTATAAACTATAAACTTA
AGGGCAAGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTTCACAAACTGTGAAAATAGTGTAAGAACTGTACAT
TGTGAGCTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAAAAAGCTAATGTGCAGGGATATTGCCTTATTTGTC
TGTAAAAAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTATCCTGTATTCTTGTTTGAATTCCTCCTCTATTTAA
GATATATACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGGTCAGTTGTAATAAATCTAGGATGTGATGATGACT
TTGTAATTTGATTTTCTGAAATCAGACCCTGAGAGGGGAAAATCTTAAAGTAAATTACATTAAATTATCTGTGCATTTCACACCAGGGAA

>71769_71769_2_RAD51D-MAP2K4_RAD51D_chr17_33428220_ENST00000394589_MAP2K4_chr17_11984673_ENST00000415385_length(amino acids)=366AA_BP=39
MPSDAPGALCPALGFSWTPSREQEHQAAGAWRVWPNLPDRERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKP
SGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATV
KALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATG
RFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPS

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Fusion Gene PPI Analysis for RAD51D-MAP2K4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAD51D-MAP2K4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAD51D-MAP2K4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource