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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAD51-HNRNPH1 (FusionGDB2 ID:71772)

Fusion Gene Summary for RAD51-HNRNPH1

check button Fusion gene summary
Fusion gene informationFusion gene name: RAD51-HNRNPH1
Fusion gene ID: 71772
HgeneTgene
Gene symbol

RAD51

HNRNPH1

Gene ID

5888

3187

Gene nameRAD51 recombinaseheterogeneous nuclear ribonucleoprotein H1
SynonymsBRCC5|FANCR|HRAD51|HsRad51|HsT16930|MRMV2|RAD51A|RECAHNRPH|HNRPH1|hnRNPH
Cytomap

15q15.1

5q35.3

Type of geneprotein-codingprotein-coding
DescriptionDNA repair protein RAD51 homolog 1BRCA1/BRCA2-containing complex, subunit 5RAD51 homolog ARecA, E. coli, homolog ofRecA-like proteinrecombination protein Aheterogeneous nuclear ribonucleoprotein Hepididymis secretory sperm binding proteinheterogeneous nuclear ribonucleoprotein H1 (H)
Modification date2020032220200320
UniProtAcc.

P31943

Ensembl transtripts involved in fusion geneENST00000267868, ENST00000382643, 
ENST00000423169, ENST00000532743, 
ENST00000557850, ENST00000530766, 
ENST00000510411, ENST00000511300, 
ENST00000524180, ENST00000329433, 
ENST00000356731, ENST00000393432, 
ENST00000442819, 
Fusion gene scores* DoF score2 X 2 X 2=813 X 10 X 5=650
# samples 214
** MAII scorelog2(2/8*10)=1.32192809488736log2(14/650*10)=-2.21501289097085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAD51 [Title/Abstract] AND HNRNPH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAD51(41011097)-HNRNPH1(179043959), # samples:2
Anticipated loss of major functional domain due to fusion event.RAD51-HNRNPH1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
RAD51-HNRNPH1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAD51

GO:0000724

double-strand break repair via homologous recombination

16428451

HgeneRAD51

GO:0006268

DNA unwinding involved in DNA replication

7988572

HgeneRAD51

GO:0006974

cellular response to DNA damage stimulus

23509288|25585578

HgeneRAD51

GO:0010569

regulation of double-strand break repair via homologous recombination

23754376

HgeneRAD51

GO:0031297

replication fork processing

25585578

HgeneRAD51

GO:0051106

positive regulation of DNA ligation

8929543

HgeneRAD51

GO:0071479

cellular response to ionizing radiation

23509288|23754376

HgeneRAD51

GO:0072757

cellular response to camptothecin

23509288

TgeneHNRNPH1

GO:0043484

regulation of RNA splicing

16946708


check buttonFusion gene breakpoints across RAD51 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HNRNPH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A4A6RAD51chr15

41011097

+HNRNPH1chr5

179043959

-


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Fusion Gene ORF analysis for RAD51-HNRNPH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000267868ENST00000510411RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
5CDS-intronENST00000267868ENST00000511300RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
5CDS-intronENST00000267868ENST00000524180RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
5CDS-intronENST00000382643ENST00000510411RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
5CDS-intronENST00000382643ENST00000511300RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
5CDS-intronENST00000382643ENST00000524180RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
5CDS-intronENST00000423169ENST00000510411RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
5CDS-intronENST00000423169ENST00000511300RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
5CDS-intronENST00000423169ENST00000524180RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
5CDS-intronENST00000532743ENST00000510411RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
5CDS-intronENST00000532743ENST00000511300RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
5CDS-intronENST00000532743ENST00000524180RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
5CDS-intronENST00000557850ENST00000510411RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
5CDS-intronENST00000557850ENST00000511300RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
5CDS-intronENST00000557850ENST00000524180RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000267868ENST00000329433RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000267868ENST00000356731RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000267868ENST00000393432RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000267868ENST00000442819RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000382643ENST00000329433RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000382643ENST00000356731RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000382643ENST00000393432RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000382643ENST00000442819RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000423169ENST00000329433RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000423169ENST00000356731RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000423169ENST00000393432RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000423169ENST00000442819RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000532743ENST00000329433RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000532743ENST00000356731RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000532743ENST00000393432RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000532743ENST00000442819RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000557850ENST00000329433RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000557850ENST00000356731RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000557850ENST00000393432RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
Frame-shiftENST00000557850ENST00000442819RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
intron-3CDSENST00000530766ENST00000329433RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
intron-3CDSENST00000530766ENST00000356731RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
intron-3CDSENST00000530766ENST00000393432RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
intron-3CDSENST00000530766ENST00000442819RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
intron-intronENST00000530766ENST00000510411RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
intron-intronENST00000530766ENST00000511300RAD51chr15

41011097

+HNRNPH1chr5

179043959

-
intron-intronENST00000530766ENST00000524180RAD51chr15

41011097

+HNRNPH1chr5

179043959

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for RAD51-HNRNPH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAD51-HNRNPH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:41011097/:179043959)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HNRNPH1

P31943

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for RAD51-HNRNPH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RAD51-HNRNPH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAD51-HNRNPH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAD51-HNRNPH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource