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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RAF1-PHC3 (FusionGDB2 ID:71827)

Fusion Gene Summary for RAF1-PHC3

Fusion gene summary

Fusion gene information	Fusion gene name: RAF1-PHC3
	Fusion gene ID: 71827
		Hgene	Tgene
	Gene symbol	RAF1	PHC3
	Gene ID	6037	80012
	Gene name	ribonuclease A family member 3	polyhomeotic homolog 3
	Synonyms	ECP\|RAF1\|RNS3	EDR3\|HPH3
	Cytomap	14q11.2	3q26.2
	Type of gene	protein-coding	protein-coding
	Description	eosinophil cationic proteinRNase 3cytotoxic ribonucleaseribonuclease 3ribonuclease, RNase A family, 3	polyhomeotic-like protein 3early development regulator 3early development regulatory protein 3homolog of polyhomeotic 3polyhomeotic like 3
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000251849, ENST00000442415, ENST00000534997, ENST00000542177,	ENST00000467570, ENST00000474275, ENST00000481639, ENST00000497658, ENST00000494943, ENST00000495893,
Fusion gene scores	* DoF score	24 X 15 X 16=5760	8 X 7 X 6=336
	# samples	28	10
	** MAII score	log2(28/5760*10)=-4.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/336*10)=-1.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RAF1 [Title/Abstract] AND PHC3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RAF1(12641190)-PHC3(169815172), # samples:3
Anticipated loss of major functional domain due to fusion event.	RAF1-PHC3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. RAF1-PHC3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. RAF1-PHC3 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. RAF1-PHC3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. RAF1-PHC3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. RAF1-PHC3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RAF1	GO:0002227	innate immune response in mucosa	12860195
Hgene	RAF1	GO:0019731	antibacterial humoral response	12860195
Hgene	RAF1	GO:0043152	induction of bacterial agglutination	23992292
Hgene	RAF1	GO:0045087	innate immune response	23992292
Hgene	RAF1	GO:0050829	defense response to Gram-negative bacterium	23992292
Hgene	RAF1	GO:0050830	defense response to Gram-positive bacterium	12860195\|23992292
Hgene	RAF1	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	12860195

Fusion gene breakpoints across RAF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PHC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-8256-01A	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
ChimerDB4	PRAD	TCGA-HC-8256	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-

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Fusion Gene ORF analysis for RAF1-PHC3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000251849	ENST00000467570	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000251849	ENST00000474275	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000251849	ENST00000481639	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000251849	ENST00000497658	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000442415	ENST00000467570	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000442415	ENST00000474275	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000442415	ENST00000481639	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000442415	ENST00000497658	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000534997	ENST00000467570	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000534997	ENST00000474275	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000534997	ENST00000481639	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000534997	ENST00000497658	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000542177	ENST00000467570	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000542177	ENST00000474275	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000542177	ENST00000481639	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
5CDS-intron	ENST00000542177	ENST00000497658	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
Frame-shift	ENST00000251849	ENST00000494943	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
Frame-shift	ENST00000251849	ENST00000495893	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
Frame-shift	ENST00000442415	ENST00000494943	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
Frame-shift	ENST00000442415	ENST00000495893	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
Frame-shift	ENST00000534997	ENST00000494943	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
Frame-shift	ENST00000542177	ENST00000494943	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
Frame-shift	ENST00000542177	ENST00000495893	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-
In-frame	ENST00000534997	ENST00000495893	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000534997

RAF1

chr3

12641190

ENST00000495893

PHC3

chr3

169815172

10401

600

754

241

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000534997	ENST00000495893	RAF1	chr3	12641190	-	PHC3	chr3	169815172	-	0.010632112	0.9893679

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Fusion Genomic Features for RAF1-PHC3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAF1-PHC3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:12641190/chr3:169815172)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RAF1

chr3:12641190

chr3:169815172

ENST00000251849

56_131

369

649.0

Domain

RBD

Hgene

RAF1

chr3:12641190

chr3:169815172

ENST00000442415

56_131

389

669.0

Domain

RBD

Hgene

RAF1

chr3:12641190

chr3:169815172

ENST00000251849

355_363

369

649.0

Nucleotide binding

ATP

Hgene

RAF1

chr3:12641190

chr3:169815172

ENST00000442415

355_363

389

669.0

Nucleotide binding

ATP

Hgene

RAF1

chr3:12641190

chr3:169815172

ENST00000251849

138_184

369

649.0

Zinc finger

Phorbol-ester/DAG-type

Hgene

RAF1

chr3:12641190

chr3:169815172

ENST00000442415

138_184

389

669.0

Zinc finger

Phorbol-ester/DAG-type

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000474275

19_26

187.0

Compositional bias

Note=Poly-Thr

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000474275

324_539

187.0

Compositional bias

Note=Gln-rich

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000474275

346_670

187.0

Compositional bias

Note=Pro-rich

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000474275

89_287

187.0

Compositional bias

Note=Ser-rich

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000497658

19_26

152.0

Compositional bias

Note=Poly-Thr

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000497658

324_539

152.0

Compositional bias

Note=Gln-rich

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000497658

346_670

152.0

Compositional bias

Note=Pro-rich

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000497658

89_287

152.0

Compositional bias

Note=Ser-rich

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000474275

919_983

187.0

Domain

SAM

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000497658

919_983

152.0

Domain

SAM

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000474275

691_720

187.0

Motif

Note=HD1

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000497658

691_720

152.0

Motif

Note=HD1

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000474275

776_810

187.0

Zinc finger

FCS-type

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000497658

776_810

152.0

Zinc finger

FCS-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RAF1

chr3:12641190

chr3:169815172

ENST00000251849

349_609

369

649.0

Domain

Protein kinase

Hgene

RAF1

chr3:12641190

chr3:169815172

ENST00000442415

349_609

389

669.0

Domain

Protein kinase

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000494943

19_26

932

984.0

Compositional bias

Note=Poly-Thr

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000494943

324_539

932

984.0

Compositional bias

Note=Gln-rich

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000494943

346_670

932

984.0

Compositional bias

Note=Pro-rich

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000494943

89_287

932

984.0

Compositional bias

Note=Ser-rich

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000495893

19_26

944

996.0

Compositional bias

Note=Poly-Thr

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000495893

324_539

944

996.0

Compositional bias

Note=Gln-rich

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000495893

346_670

944

996.0

Compositional bias

Note=Pro-rich

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000495893

89_287

944

996.0

Compositional bias

Note=Ser-rich

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000494943

919_983

932

984.0

Domain

SAM

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000495893

919_983

944

996.0

Domain

SAM

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000494943

691_720

932

984.0

Motif

Note=HD1

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000495893

691_720

944

996.0

Motif

Note=HD1

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000494943

776_810

932

984.0

Zinc finger

FCS-type

Tgene

PHC3

chr3:12641190

chr3:169815172

ENST00000495893

776_810

944

996.0

Zinc finger

FCS-type

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Fusion Gene Sequence for RAF1-PHC3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>71827_71827_1_RAF1-PHC3_RAF1_chr3_12641190_ENST00000534997_PHC3_chr3_169815172_ENST00000495893_length(transcript)=10401nt_BP=600nt
CAACACACAACTTTGCTCGGAAGACGTTCCTGAAGCTTGCCTTCTGTGACATCTGTCAGAAATTCCTGCTCAATGGATTTCGATGTCAGA
CTTGTGGCTACAAATTTCATGAGCACTGTAGCACCAAAGTACCTACTATGTGTGTGGACTGGAGTAACATCAGACAACTCTTTTCTCAGC
ACAGATATTCTACACCTCACGCCTTCACCTTTAACACCTCCAGTCCCTCATCTGAAGGTTCCCTCTCCCAGAGGCAGAGGTCGACATCCA
CACCTAATGTCCACATGGTCAGCACCACCCTGCCTGTGGACAGCAGGATGATTGAGGATGCAATTCGAAGTCACAGCGAATCAGCCTCAC
CTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCCCGTGCCAGCACAAAGAGAGCGGGCAC
CAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAAGTGA
TGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGCTGCCAGGATATCGCAGATGAATTCAGAG
CACAGGAGATTGATGGACAGGCCCTTCTCTTGCTGAAAGAAGACCATCTCATGAGTGCAATGAATATCAAGCTAGGCCCAGCCCTGAAGA
TCTGTGCACGCATCAACTCTCTGAAGGAATCTTAACAGGAACATGAAGCCTTGATAAAACAGCAGTTTTACTTTTCTCACAAAAACTTGT
AAGGTAAAGGCCTAACTTGGTCTAGAATATGACACTTATTGTGGTGGATAGCCAAGCACATTGGGATCTCCACATCAAATACTGACATTT
CTTCTACAGGTATAATAATTCATCATGCATTTTCATAATTAATAAACATTGGTAAAATTAATTTTACAGGTTACATGAAACATTGAAAGA
CTTGTTACAGAGGGCCATGATATTTTTCAAAGAAATGTGTTATACTAGATAATTTTTTTAAAGGTGATGTTTATCATTAATATAAAGAAT
CCTTTTAAAAGTAATTTAATGATTTACATTTCTCCTCTTTTGATTCAATTTTCTTATACATTTTTTCTACCCTATTAGTTTTCTAAAGGT
TGTCATGAGAGGTATATTATGGAATAATTTAGTAGTCCAGTGACAGAATCGTATGAAATCAGTGTACATTTTAAAAAACATGTCTTTTAG
ACATATGCTTTATCTATAAAAAAGGAATTGTGTTCTAGTATGAACAATACTGATCTGGAAGTGAGAAGAGTTAGTTTCTATTCCAAACTT
GACCAAGAATTTGGTTTGACTGAGAACGTTTTCCTCTCAGTTTTTGTACATTTATTTAGAGCAGTGGTTCTCAGTGGAGGTCAGTTTTGA
TCGCCAGGGGACATCTGGCAATGTTGAGACATTTTGGTTGTCACAGCTTGGGGGTGGGTTCAGGGGAGGGTTGCTACTGGTGTCTAGTAG
TTAGAAGCCAGAGATGTTTCTAAACATCTTATAATGCACAGGACAGCACCCCTCCACTGTAAAGAATTATTGGTTCAAAAATATCGGTAC
TGCCAAGGTTGAGAAACTCTGATATAGAAGGAGTGATAAATATTGTTTTCACCCAAAGGAATACTTTTAAAGGATGAAGCTTACTAAACA
TATATGATGGAAGTATTATTCAGATAACATTAATATTCTGCTGAATAATTTTTTCTAGTTTAATCATACTAGAAAAAGAAAAAAAATCTA
CAAATTGTCCTATAAAATAAGGACAAACATGCAAATAATTTAACTCTCAGAAAGTACTAATTCATTCTGATTATCTTTCATACCTCTGTG
CTCCTCTGCACTGACGAAGACATAATATGATTATACCTATGAACTAGTGCACAGCCTTTTCTGGCAAGAAAATAGTTTGTAGCAGATACG
TGGTTGCTCTTTGGATTTTTTTCTATTGTTGAACATGCTGGGACTAGCTAGAATGCACATTCCTACTTCCTTTACCAAACGTTTGCATGC
TTCCTGCAAAGCACTTACCAAGTGATTTCTCTTGAACCATCGGATATAATTTTGTATGTACATGTTTGAGGAAAAAAATGTAAAGCAAAA
CCTTTTACTGAACAGTGTTCTATAGAATTATGACACTAAAACAAAATTGTTTGTGGAAGCCCTGAAAGCTTTATAGTCCTGGACATCAAA
AATTTTATTTGAGATGATGAATGTTTTGTTTTCATCTTTTCTTATATTACCACAATTGAGATATTTTAGTAATTGAAGGAACATACACAG
ATATTTGGCAGAAGTCGAGTAAGGAGGGGAAAAAAAGAGTCCGTGAGTTTCAGTCATTTTCACTGCTCTTTTCAAAAAGATTGTGTTGAG
CTGGTAGAAGACTAAAGATGTCACTGAAGACATCACAGATACTATATTTATCTTTTGGCTTTGTGTACATTAGAGAATGTTGATTATTTT
TATACAAAAATACAGCGGGTAATTTTTTTAATCTTTAGATGCCTCTTGTTTGAATGTATGCTTTGTGGAATTCTTTGTGTAGTAATGTTT
TAAAAAAAGATGTTTACTGATAGTTACATGTAGGATTAGAATATGTAATATAATATAAGGCTCATGTTCCAGACCTACGATAGCTTGTAG
TCTATGTTACGTATTTCTTTATATCACATTTTTAATCATTGGATTAAAGTATCAAGGAAAGCTAGGTACTCTATAATGAGTTTTCATTTA
TTAGCAGTTAATCATCATGACAGAATTGTCATATGCTTGACTTTTCCCTCTTCTTGGAATTTCAGAACACAAATACAGGCTAAGCATTAG
TAAGAGATGGCCCACAGTATGAGAGAGAGAGGTGCAACGGAAAATCTCGCCTGGAATTAAAACTTTTCATAGATTATCCACGGTTAATAC
AAAATTTATTATATGGGGATAGACTGCTCCAGCAATAATGATTACATCCTATAACTGTATTACCTATGGCCTTTAAGGTATCAATTTTGA
ACTGTGTTGTAGGCTCTCCTTTTATTTGTTCTCTTTCCTAATAGCAGCCATTCTGTACTTATTGAAAGCCCCTGTGCCTACTGCTGTCTT
AAGTATTCAGGAGGGGCTTACAAGAGGGTTTTCTATTGGAGAATACCGTATAATCTTAAATCTAGTCCAGATCTCTGTTGTCCCCACTCA
AAACATACACAAAATATGCACTTGCTTTTTTCAAGTGAGTTTTTATTTAAAAATGGCTTGTTTGCTATCACATTGGTGCAGCTGTTTCTT
TCAAGATGAGTTAATCATCTTAATTTCAAAGCTTCAGCTATATATAATGGATATATAGACAACACTGAGCATCCACCTCTCTCCTGAGCT
TTAAAGCAGAGTTTCAGTATGATATAGGTGGGGAGAGTAAATTGTTTTCATATCCTTTCATACTACTACTAATAGTTTTAGGATTTTGAC
TGGGGAGAGATAATGACAAACAGAAAGGGAACATGGAGGTTCTTCCTACTTTTGCTACCTAAGTTTGCATTTTCTGACTTCCTTGCAGTG
TTGCACTCTTTGTCCCATTGGGATAAAAAGCATAAGTTTGAAATTTTGCTTTAAGCCTTGTGTTCCTGGGGAAGTTAAACAACTAAGAGA
GCTGATTTGTAAAAATTATTTTTTATATGACATTAATATTCATCAAGCCTTGTGTAGGCATGTGTAAGACACAGCTATGCAGCTTTGAGT
AGTCAATATAGTATGAGATAGAGTGTTGTCCCAAATCCTCCTGTCACTTTTTAAGTAGCATATTATTTCCCTGATGGTCCTGTTACTTTG
CTGTTGAATGCTCTAAACAGAACTTTTTAAAAGGTGTGTTTTAAGAGCAGTCACCTAGGAGTAGACAAGGTGGAATGGGAGGAGAGAAAT
GGTAATGCAAAAGCTTGAGCATGGGAAGAGTCAGAGGAGGAGGCCATCATCCTTGTTAGCTTAGCCTACTTCAACACTGAGCACATTTCT
GCACTTTTGAAGTGAAATTCATGTTTTACTTAGAAGAAATAATTTTCTTTCATTAGGGATCCCAGTTGATTTTTGTTTCCTGGTGTATCA
AAATACTTAGAACTATGAAACAAGTATTATTGTGATCATGCCTTTGAATAATTTTTGACGTAGCTTATCTTCATGTATCAAGTATAAAAT
TATAATGAGACATCTATTCACAAATACAAGTCTTAGATTGAATTGAAATGTGTTATAGTGCCCTGTCTCCCACTGACTTGTTCAGTTAAA
TGTCTTAAAGTACATTATGTACATCTTCAGGCTTTTGGTACCACAATGGCACAAGTATGGTAGGGAGGCAATATAGTCTTAGGCTATATG
CCTATATTAAGTGTGTATAAACAATTTTTGAAAGAATACACTATTATAGATGTATGTGAGTGATGCTGACCTGACAGCCATATCCAGTGG
ATGAAACTGACTGGACACACTGTTAAAATGTTTTAAAGATGTATTTTCAGCCAGAACAGCCTGGTTATAGTTTGTGGTTTTCACCTTGGT
GGATTGCAGGAACACATGCAGCCTACTGGCATTGAGCATTAGCTAATGGCATGAAAGGGCCTCATCTCACTACCTCTCTAAGGCCTCTAG
CTCCAAGAAAACCATGAAAACTTCTTTCTTGGAGAGATCTTTGTCTCAGAATCCTTAGAGAGGATTTCGTATGGGGGCTAACTTTAGGAA
GGGAGGCAGCTGGGGCAGGACTTTCTGATACCTGACAGTCATGTTCCAGAGCAACCTTTGGGCAGTGGAAACTGGCGCATCTATGCAAAA
TGATTGCTCAATCTCTATCTTGTGTACTACATATGTAACTAGCTGGGCCCTAAGGAAGGTTTTCTAGGGGGAAGGATAGGGAAGTAGAGG
AGGAGACAAGTAGGAGGAACAAAGCATTCTAGACCCAAGAGGATAGAAGATATTTAGGATAGATATGGCTTTCATCCATAGTTCAAAATA
ATGCGTTTTGTTAGATGCCAGTTATAGCAGTAAATAGGTTATAGTTTTTATATGTCAAGATTTACCTGTAATCAGACTCATTCTTTCACT
CTCTATACCCACTGTCTCCATGCTTGGGAGCATGGATATTAATAGTTCCAGTGATGTAGAAGTTAGTGATTTTTGATTTCTGAAAAAGGT
GAGAACCTTTTATTACAGTTGGAGAATATTTGTCAAAAATTCAAAGGTTGTTGTAATTGAGTTGCCAGAATTACAGAGTTTCCATTTTCA
GATATCACAGTTGAATCACCTCTGTAGATTGTTATAAAGAGAGGCATTTTAAGATAGTATTTTATTTGCTAGGTTGTGTCTCAGTCTAAG
AATTGGGAAAAGAAGAGCTATAGGTTTCTCTTTCCTAGTCTGGATTTCAGTAAACACAAGCCTACCTCTGCTTCTTTGGTTCACAGCAGT
GTGGATCATGAAATGAACTGTTTACCCACATTCATCAATATTGGTATTTTACAAATCTACTTGGAGCATTTAATTTCATCTCAAAGATTG
TGATCCACTTTAGATAAGCACAAATACAGTATTAGGAAAAGTAAATATGCAATCTTACTAAAATTTCAACTTGTTAAGCTGTATATCTTA
AAAGAAATTATTTGGGGCTGGGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTAGATCACCTGAGGTCAGG
AGTTCGAGACCAGCCTGACCAATATGGTGAAACCCTATCTCTACTAAAAACACAAAAATTAGCTGGGTGTGGTGGCATGCACCTGTAATT
CCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTGAACCCAGGTGGTGGAGGTTGCAGTGAGCCAAGATCACACCCCTGCACTCCAGC
CTGGGTGACAGAGCGAGACTCCATCTCAAAAAAACAAAACAAAAAATTATTTGGGAAGATACGTCCTCTTTTATTAGAAGTTCATAAAAT
GTATCATATAGTTTTGTTCACAGTAGTTATATAAGCTTTCTTCAAATAAATTTAAAATTAGATTACCTTCTTTGGAAAAAGAATTTCCTA
AATTTTTAAGAATTTTCAAAGTTTTACATATTAGTTTTTAGAACCTAATCCGTTTTAAAATTGTACTATGAGAAAGCTTTTTTTTGAAAG
TTGTAAAGCATTAATACAAATAATACAAATATAATTATTACCATCACATTCCAGAGAATATGGCTTTTTCTAAACTTTCAATTTAGAAAA
CATACATTAAGGGAGAATCTCTGCCCTCCTTTTCAGCTCTGAAGATCAGCTTTTCTACTCAGACACATGCACACACCCCTTCCAAGTGTC
ATGTTTATGGGAACATTTGGGAAATGTTTTCCAGATGTTTTATTTTTTCCCTTTTATAGTTTGTTGACATTTAATTTTACTTAAAGATGA
CAATTTTAATCGGAAATGTTAGAGGTACAACATAGTGAGGTTCTAGCTAGCTTTATACTTTTGAAAAATATTTTTGTTTCTACTGCTTTT
TACAAGTACTAGTCCTCTCAGTGATACTGGTGGTGTTCAGTATGAATCCATAGAAAGAAAACAAAATTTGTTGTTTAAAAAAAGCAGAGT
AATGAATGAATTTCAGTTTTGAAAACAACATAATTTGAAAACACTGTTATACTAACATGGCAAGGTGTTAATTAAATATAAGAGTAAGGT
AGTAAGTTCTTTTAGAGCACCTGTTTAAATTTACTCCAGTAATCATCTTAAGGATTGATAGTCACCATCACTTATTGGCTTAAAAGTTAT
ATTTCATGGAATATTATCAGTGTTAAATCCAAGCTTTGTGGAGCTTTAAGTGATGGTGGTGAAAAAGTTGGTGTTTATGAGAGAGTGGTG
GGGTGTCTAGTCATTAGTGAAGTTAAACATCAACCTGTTTTAGAAAGAATTTTTTAGTCTTGCCTAAAGTAAACCAGAAGTGTCTAGTGT
TTAAATCTTTATTTAGAATGCTTCTCTTAAAAGTATTTTTTGTTTTGGGTAGTATTAAATAATCAGTAAATAATCTATTTCAGTAGTAAA
TAATGAATTAAGATGATGATGAATGAGGATTAACACACTGGTCTGGAGACTGGGGTTTTATTTCAGTGGGTTAGCTGTGTGTGACATGTT
GGGCAATTACTCAGCTGTTTTAACAGCTTCCAGATATGCAGTATGGTGCCTGTACTACTCAAAAGTTGATTTTGGTTTAATTCATCTTTA
AGGTACCTCCCAGCTCTAAAACTATGATTCTAGGCTGTGTAATGGGGTTATTCCTACTTTATTCTCTTTCCTTTTTTAAGGGTTCATTTT
ATACTTAATAAGCATCCATTTCTTGGGTCACCTACAGTCTTTGTTCTCCTAAGGATTAAAATAGAAAATTCATACATAACAAGCAAATGA
TGACATTTTCCTAAATGCTCCTTATTGGTTAACCACTGAATATATGAACACATATGAATATTGTCATTCATGTACTTAAATTCATTTAGC
AAACTATTTGAACACTTACATGTGCAGTGTTTGGTGAACATGACATGAGGAACTAGTAGTAAGTAAAATCTTCCCCCCAAAATTCATTGT
GGCTTAAATAAATATGAACATAATCATTACTACTTAATATACTGAGAGGGAATCTTAATAAACTTGGAACTGGGAGGGAATATTTGTATA
CATTGGGTAAAGGGTTAGGCTAGATGACATCTAAGGGGTCTGAGTGAATCATATCATAATTTTTATAACACATTTCACATACTAAACATC
AGTTGGCCCCATACCTGATTAAGTTACAAAATTTAGGAGACTTAACATTAAGGACTTACAGGTTGAGACAGCCCGTATTTCACAACATTA
TTTTGACACTTGACTCTATTCCAGAGTTGTTGCTATACAAGGCATGTGGCAGAACAAAAAAAAAGCTGGTGTTGATATAAGAGCTTTTTA
CCCAGTATTGACAGTGAGCAACTTTCTTTCTTTTTTTTTTTTTTTCTTTTTTTTTTTTTTGAGATGGGTTCGCTCTGTTGCCCAGGCTGG
TGTGCAGTGGTGCGATCTCAGCTCACTGCAACCTCCACCTCCCGGGTTGAAGCGATTGTCTTGCCTCAGCCTTCCAAGTAGCTGGAATTA
CAGGTGCCCGCCGCCACACCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGCTTCACCATGTTGGCCAGGCTAGTCTCGAACTCTTGA
CCTCAAGTGATCCACCTGCCTTGGCCTCCCTAAGTGCTGGGATTACAGGCATGAGCCACCACACCTGTCCGACAGTGTAGCAACTTTCTA
AAACTGAAAAATCTCAAAGGAGATCATTGGAACTGACTTGTTCATTTATTTTTTGTTTTTAAATTAAGAAAGATTACACAAAATAAGTGT
TACTGTACTTTAAGCTATTACAAATATCCAACTTTTAAAGATATGTAAGAATCAGTAATATTCTAGAAAGCACATATATAGTAAAAGGGC
ATCCTTTAAATGTAGAACGGGTAAACATGAAACAGTTCCATGCTTGAATTGTTAAGTATCTAGGGGGTAAACATTGAATGGGAGAATCAT
TTATTGGGTTAAGGTCCCTTCCTTGTCATTCTGGGATCTGTGAATCACATTGTAATTCCTGTTGACAAAGCTTTACTTGTTAACATCAGT
TGATACTGACATTCTCCATAAAGATATAGAATGAAAATATCTATTAAAAATAGTTTATCATTGTTTTAGCTTTTTTGTTTTGTTTGTTTT
GAGACAGAGTCTCACTGTCACCCAGGCTTGAGTGCAGCGGTGTGATCTTGGCTCAATGCAACCTCCACCTCCCAGGTTCAATAGATTCTC
CCACCTTGGCCTCCCAAGTAGCTGGGATTACTGGCATGCACCACTATGCCTGGCCAGTTTTTTGTATTTTTAGTAGAGATGGGGTTTCAC
CATGTTGGCCAGGCTGGACTCGAACTCCTGACCTCAAGTGATCCGCCCACCTCAGCCTCCCAAAGTGCCGGGATTATAGGCATGAGCCAC
TGCGCCTAGCCTGTTGCAGCTTTTTAAAGCAGGAAAATATCCATATAAACTGTTGGGTTAGAATCTATATTAGAATCTTTCAAACTAATT
GAAAACAGGAAGACTATCATCTAAGTAGCCAGATAATCTGGGTTTCAAAAAGTTATTCCATGGTACTGGTTTAAAAAATACTTTTCAAGT
GTTTTAATTTTTAAAGTGTAACTAATTCTTCAAATATGTTATGCTGTTAAAATATGTATTCCATAAGTACTTTTTGTATATGTATTCTTA
AATTTTAAAAAGTCAACTGAATGCGCAAAGATGATATAATTTTGGATGTAGACATTTAAACTAGATTCCCAGTCCTCTCCTTCAAAAGCT
TGGTCTTTGTTTTTCCTATAGGGAAAAAAGTCAAAATAAGTTCCAAAAACTATCCTCAAAGTAGTATTGTGCTTGTAGTAAATGAAGGTT
GGATGGATGGATACTGACAATGGTGGCAGGCATTTCAAGCCTTTTAAATTAGTACTTTTTGTCGTCTTGCTTATTAAAATTTTGTTAATT
TTAGCAAAGACCAATTGTTGTGATAAACTGGTGTTTTTTGGATGCTTCAAGCACACGTTAACCAATTTTTTAATTCCCCTTTTGGTTCCT
CCCATTGTTCTAAAATAGGACTTTCATATTATTAAAACCTCAAAAGATGATCCACCCAGGATGAACAAAGATCACCAAGGGGAAAGAAAA
CATTTTTTATCTTTACAGAAAACATGTTAAGATTATATATAGATGTATTCTTTACATTGGATATTGTATTAGAGTCCTCCTTACAAGAAA
TGAAATAGTTTTTAGCACTCTTAGCATTAGAGTTCCTAGATTGGTGTTGATAGCTACAGTTTTAAAATGTATAACCTGAAAATGAAGGTT
AATTTTGCATTGTAAGAGCACATTTGATCTATGTAAAAAGTGTCCATTTGGTGTATTTTTTTAAAAAAGAGAAAGCACTTTCATATTAAG
TAGCATGTGTATGAATTTAGATTTTCATATTTGTTGTGTCTGTATTCAGTGAAGTAAATTGAGCATTTAAATGTTTGTTGATGGCAACAT
TAACTATTAAATTAAAGCACCTTATACTCTGCTGCTTAACTTGCTTGTAATTGCACCTTTGTTACCTGCACATTTTCATATAGAATATTG
TTGTAACATTGCTTCATGTGGGTCTGGATGGAAGATTAGTGGGCCTACAGGATCATTTATTTATATTGTTTATATTACAATAATATATTG

>71827_71827_1_RAF1-PHC3_RAF1_chr3_12641190_ENST00000534997_PHC3_chr3_169815172_ENST00000495893_length(amino acids)=241AA_BP=190
MKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLFSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTT
LPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGS

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Fusion Gene PPI Analysis for RAF1-PHC3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	RAF1	chr3:12641190	chr3:169815172	ENST00000251849	-	10	17	331_349	369.3333333333333	649.0	PEBP1/RKIP
Hgene	RAF1	chr3:12641190	chr3:169815172	ENST00000442415	-	11	18	331_349	389.3333333333333	669.0	PEBP1/RKIP

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for RAF1-PHC3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for RAF1-PHC3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source