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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASNSD1-PMS1 (FusionGDB2 ID:7194)

Fusion Gene Summary for ASNSD1-PMS1

check button Fusion gene summary
Fusion gene informationFusion gene name: ASNSD1-PMS1
Fusion gene ID: 7194
HgeneTgene
Gene symbol

ASNSD1

PMS1

Gene ID

110599588

5378

Gene nameASNSD1 upstream reading framePMS1 homolog 1, mismatch repair system component
SynonymsASNSD1|ASNSD1-SEP|NS3TP1HNPCC3|MLH2|PMSL1|hPMS1
Cytomap

2q32

2q32.2

Type of geneprotein-codingprotein-coding
DescriptionASNSD1 upstream open reading frame proteinAsparagine synthetase domain-containing protein 1HCV NS3-transactivated protein 1alternative protein ASNSD1PMS1 protein homolog 1DNA mismatch repair protein PMS1PMS1 postmeiotic segregation increased 1human homolog of yeast mutLmismatch repair gene PMSL1rhabdomyosarcoma antigen MU-RMS-40.10Brhabdomyosarcoma antigen MU-RMS-40.10E
Modification date2020030320200327
UniProtAcc

Q9NWL6

PMS1

Ensembl transtripts involved in fusion geneENST00000607535, ENST00000607690, 
ENST00000607829, ENST00000260952, 
ENST00000607062, 		ENST00000374826, 
ENST00000409823, ENST00000409985, 
ENST00000421722, ENST00000432292, 
ENST00000447232, ENST00000418224, 
ENST00000441310, 
Fusion gene scores* DoF score3 X 2 X 3=1811 X 6 X 7=462
# samples 311
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/462*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASNSD1 [Title/Abstract] AND PMS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASNSD1(190526336)-PMS1(190708690), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ASNSD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PMS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-IQ-A61G-01AASNSD1chr2

190526336

+PMS1chr2

190708690

+
ChimerDB4HNSCTCGA-IQ-A61GASNSD1chr2

190526336

+PMS1chr2

190708690

+


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Fusion Gene ORF analysis for ASNSD1-PMS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000607535ENST00000374826ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607535ENST00000409823ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607535ENST00000409985ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607535ENST00000421722ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607535ENST00000432292ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607535ENST00000447232ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607690ENST00000374826ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607690ENST00000409823ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607690ENST00000409985ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607690ENST00000421722ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607690ENST00000432292ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607690ENST00000447232ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607829ENST00000374826ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607829ENST00000409823ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607829ENST00000409985ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607829ENST00000421722ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607829ENST00000432292ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5CDS-intronENST00000607829ENST00000447232ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-3CDSENST00000260952ENST00000418224ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-3CDSENST00000260952ENST00000441310ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-3CDSENST00000607062ENST00000418224ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-3CDSENST00000607062ENST00000441310ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-intronENST00000260952ENST00000374826ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-intronENST00000260952ENST00000409823ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-intronENST00000260952ENST00000409985ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-intronENST00000260952ENST00000421722ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-intronENST00000260952ENST00000432292ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-intronENST00000260952ENST00000447232ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-intronENST00000607062ENST00000374826ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-intronENST00000607062ENST00000409823ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-intronENST00000607062ENST00000409985ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-intronENST00000607062ENST00000421722ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-intronENST00000607062ENST00000432292ASNSD1chr2

190526336

+PMS1chr2

190708690

+
5UTR-intronENST00000607062ENST00000447232ASNSD1chr2

190526336

+PMS1chr2

190708690

+
In-frameENST00000607535ENST00000418224ASNSD1chr2

190526336

+PMS1chr2

190708690

+
In-frameENST00000607535ENST00000441310ASNSD1chr2

190526336

+PMS1chr2

190708690

+
In-frameENST00000607690ENST00000418224ASNSD1chr2

190526336

+PMS1chr2

190708690

+
In-frameENST00000607690ENST00000441310ASNSD1chr2

190526336

+PMS1chr2

190708690

+
In-frameENST00000607829ENST00000418224ASNSD1chr2

190526336

+PMS1chr2

190708690

+
In-frameENST00000607829ENST00000441310ASNSD1chr2

190526336

+PMS1chr2

190708690

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000607535ASNSD1chr2190526336+ENST00000441310PMS1chr2190708690+2562152472368773
ENST00000607535ASNSD1chr2190526336+ENST00000418224PMS1chr2190708690+2560152472368773
ENST00000607690ASNSD1chr2190526336+ENST00000441310PMS1chr2190708690+25009002306768
ENST00000607690ASNSD1chr2190526336+ENST00000418224PMS1chr2190708690+24989002306768
ENST00000607829ASNSD1chr2190526336+ENST00000441310PMS1chr2190708690+25009002306768
ENST00000607829ASNSD1chr2190526336+ENST00000418224PMS1chr2190708690+24989002306768

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000607535ENST00000441310ASNSD1chr2190526336+PMS1chr2190708690+0.0002913050.9997087
ENST00000607535ENST00000418224ASNSD1chr2190526336+PMS1chr2190708690+0.0002890840.99971086
ENST00000607690ENST00000441310ASNSD1chr2190526336+PMS1chr2190708690+0.0002732980.9997267
ENST00000607690ENST00000418224ASNSD1chr2190526336+PMS1chr2190708690+0.0002708260.9997292
ENST00000607829ENST00000441310ASNSD1chr2190526336+PMS1chr2190708690+0.0002732980.9997267
ENST00000607829ENST00000418224ASNSD1chr2190526336+PMS1chr2190708690+0.0002708260.9997292

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Fusion Genomic Features for ASNSD1-PMS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ASNSD1chr2190526336+PMS1chr2190708689+0.0003295610.9996705
ASNSD1chr2190526336+PMS1chr2190708689+0.0003295610.9996705
ASNSD1chr2190526336+PMS1chr2190708689+0.0003295610.9996705
ASNSD1chr2190526336+PMS1chr2190708689+0.0003295610.9996705

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ASNSD1-PMS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:190526336/chr2:190708690)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASNSD1

Q9NWL6

PMS1

PMS1

932

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePMS1chr2:190526336chr2:190708690ENST00000409823012571_6390894.0DNA bindingHMG box
TgenePMS1chr2:190526336chr2:190708690ENST00000441310413571_639194933.0DNA bindingHMG box
TgenePMS1chr2:190526336chr2:190708690ENST00000447232412571_639194771.0DNA bindingHMG box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASNSD1chr2:190526336chr2:190708690ENST00000260952+16285_6010644.0DomainNote=Asparagine synthetase
HgeneASNSD1chr2:190526336chr2:190708690ENST00000260952+162_1840644.0DomainGlutamine amidotransferase type-2


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Fusion Gene Sequence for ASNSD1-PMS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7194_7194_1_ASNSD1-PMS1_ASNSD1_chr2_190526336_ENST00000607535_PMS1_chr2_190708690_ENST00000418224_length(transcript)=2560nt_BP=152nt
GTGGCTAATGCCGTAGGCTCCTTCAGGGCTGAGCCATCCCGCGTGTCTTGCGCTCGGTGGAAATGCCCAGCCGAGGGACGCGACCAGAGG
ACAGCTCTGTGCTGATCCCCACCGACAATTCGACCCCACACAAGGAGGATCTAAGCAGCAAGGCAGTTATTTGGCAGAAAAGCAGAGTAT
CAGATCACAAGATGGCTCTCATGTCAGTTCTGGGGACTGCTGTTATGAACAATATGGAATCCTTTCAGTACCACTCTGAAGAATCTCAGA
TTTATCTCAGTGGATTTCTTCCAAAGTGTGATGCAGACCACTCTTTCACTAGTCTTTCAACACCAGAAAGAAGTTTCATCTTCATAAACA
GTCGACCAGTACATCAAAAAGATATCTTAAAGTTAATCCGACATCATTACAATCTGAAATGCCTAAAGGAATCTACTCGTTTGTATCCTG
TTTTCTTTCTGAAAATCGATGTTCCTACAGCTGATGTTGATGTAAATTTAACACCAGATAAAAGCCAAGTATTATTACAAAATAAGGAAT
CTGTTTTAATTGCTCTTGAAAATCTGATGACGACTTGTTATGGACCATTACCTAGTACAAATTCTTATGAAAATAATAAAACAGATGTTT
CCGCAGCTGACATCGTTCTTAGTAAAACAGCAGAAACAGATGTGCTTTTTAATAAAGTGGAATCATCTGGAAAGAATTATTCAAATGTTG
ATACTTCAGTCATTCCATTCCAAAATGATATGCATAATGATGAATCTGGAAAAAACACTGATGATTGTTTAAATCACCAGATAAGTATTG
GTGACTTTGGTTATGGTCATTGTAGTAGTGAAATTTCTAACATTGATAAAAACACTAAGAATGCATTTCAGGACATTTCAATGAGTAATG
TATCATGGGAGAACTCTCAGACGGAATATAGTAAAACTTGTTTTATAAGTTCCGTTAAGCACACCCAGTCAGAAAATGGCAATAAAGACC
ATATAGATGAGAGTGGGGAAAATGAGGAAGAAGCAGGTCTTGAAAACTCTTCGGAAATTTCTGCAGATGAGTGGAGCAGGGGAAATATAC
TTAAAAATTCAGTGGGAGAGAATATTGAACCTGTGAAAATTTTAGTGCCTGAAAAAAGTTTACCATGTAAAGTAAGTAATAATAATTATC
CAATCCCTGAACAAATGAATCTTAATGAAGATTCATGTAACAAAAAATCAAATGTAATAGATAATAAATCTGGAAAAGTTACAGCTTATG
ATTTACTTAGCAATCGAGTAATCAAGAAACCCATGTCAGCAAGTGCTCTTTTTGTTCAAGATCATCGTCCTCAGTTTCTCATAGAAAATC
CTAAGACTAGTTTAGAGGATGCAACACTACAAATTGAAGAACTGTGGAAGACATTGAGTGAAGAGGAAAAACTGAAATATGAAGAGAAGG
CTACTAAAGACTTGGAACGATACAATAGTCAAATGAAGAGAGCCATTGAACAGGAGTCACAAATGTCACTAAAAGATGGCAGAAAAAAGA
TAAAACCCACCAGCGCATGGAATTTGGCCCAGAAGCACAAGTTAAAAACCTCATTATCTAATCAACCAAAACTTGATGAACTCCTTCAGT
CCCAAATTGAAAAAAGAAGGAGTCAAAATATTAAAATGGTACAGATCCCCTTTTCTATGAAAAACTTAAAAATAAATTTTAAGAAACAAA
ACAAAGTTGACTTAGAAGAGAAGGATGAACCTTGCTTGATCCACAATCTCAGGTTTCCTGATGCATGGCTAATGACATCCAAAACAGAGG
TAATGTTATTAAATCCATATAGAGTAGAAGAAGCCCTGCTATTTAAAAGACTTCTTGAGAATCATAAACTTCCTGCAGAGCCACTGGAAA
AGCCAATTATGTTAACAGAGAGTCTTTTTAATGGATCTCATTATTTAGACGTTTTATATAAAATGACAGCAGATGACCAAAGATACAGTG
GATCAACTTACCTGTCTGATCCTCGTCTTACAGCGAATGGTTTCAAGATAAAATTGATACCAGGAGTTTCAATTACTGAAAATTACTTGG
AAATAGAAGGAATGGCTAATTGTCTCCCATTCTATGGAGTAGCAGATTTAAAAGAAATTCTTAATGCTATATTAAACAGAAATGCAAAGG
AAGTTTATGAATGTAGACCTCGCAAAGTGATAAGTTATTTAGAGGGAGAAGCAGTGCGTCTATCCAGACAATTACCCATGTACTTATCAA
AAGAGGACATCCAAGACATTATCTACAGAATGAAGCACCAGTTTGGAAATGAAATTAAAGAGTGTGTTCATGGTCGCCCATTTTTTCATC
ATTTAACCTATCTTCCAGAAACTACATGATTAAATATGTTTAAGAAGATTAGTTACCATTGAAATTGGTTCTGTCATAAAACAGCATGAG
TCTGGTTTTAAATTATCTTTGTATTATGTGTCACATGGTTATTTTTTAAATGAGGATTCACTGACTTGTTTTTATATTGAAAAAAGTTCC

>7194_7194_1_ASNSD1-PMS1_ASNSD1_chr2_190526336_ENST00000607535_PMS1_chr2_190708690_ENST00000418224_length(amino acids)=773AA_BP=1
MRSVEMPSRGTRPEDSSVLIPTDNSTPHKEDLSSKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSF
TSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGP
LPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNID
KNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILV
PEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELW
KTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQI
PFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYL
DVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEG

--------------------------------------------------------------
>7194_7194_2_ASNSD1-PMS1_ASNSD1_chr2_190526336_ENST00000607535_PMS1_chr2_190708690_ENST00000441310_length(transcript)=2562nt_BP=152nt
GTGGCTAATGCCGTAGGCTCCTTCAGGGCTGAGCCATCCCGCGTGTCTTGCGCTCGGTGGAAATGCCCAGCCGAGGGACGCGACCAGAGG
ACAGCTCTGTGCTGATCCCCACCGACAATTCGACCCCACACAAGGAGGATCTAAGCAGCAAGGCAGTTATTTGGCAGAAAAGCAGAGTAT
CAGATCACAAGATGGCTCTCATGTCAGTTCTGGGGACTGCTGTTATGAACAATATGGAATCCTTTCAGTACCACTCTGAAGAATCTCAGA
TTTATCTCAGTGGATTTCTTCCAAAGTGTGATGCAGACCACTCTTTCACTAGTCTTTCAACACCAGAAAGAAGTTTCATCTTCATAAACA
GTCGACCAGTACATCAAAAAGATATCTTAAAGTTAATCCGACATCATTACAATCTGAAATGCCTAAAGGAATCTACTCGTTTGTATCCTG
TTTTCTTTCTGAAAATCGATGTTCCTACAGCTGATGTTGATGTAAATTTAACACCAGATAAAAGCCAAGTATTATTACAAAATAAGGAAT
CTGTTTTAATTGCTCTTGAAAATCTGATGACGACTTGTTATGGACCATTACCTAGTACAAATTCTTATGAAAATAATAAAACAGATGTTT
CCGCAGCTGACATCGTTCTTAGTAAAACAGCAGAAACAGATGTGCTTTTTAATAAAGTGGAATCATCTGGAAAGAATTATTCAAATGTTG
ATACTTCAGTCATTCCATTCCAAAATGATATGCATAATGATGAATCTGGAAAAAACACTGATGATTGTTTAAATCACCAGATAAGTATTG
GTGACTTTGGTTATGGTCATTGTAGTAGTGAAATTTCTAACATTGATAAAAACACTAAGAATGCATTTCAGGACATTTCAATGAGTAATG
TATCATGGGAGAACTCTCAGACGGAATATAGTAAAACTTGTTTTATAAGTTCCGTTAAGCACACCCAGTCAGAAAATGGCAATAAAGACC
ATATAGATGAGAGTGGGGAAAATGAGGAAGAAGCAGGTCTTGAAAACTCTTCGGAAATTTCTGCAGATGAGTGGAGCAGGGGAAATATAC
TTAAAAATTCAGTGGGAGAGAATATTGAACCTGTGAAAATTTTAGTGCCTGAAAAAAGTTTACCATGTAAAGTAAGTAATAATAATTATC
CAATCCCTGAACAAATGAATCTTAATGAAGATTCATGTAACAAAAAATCAAATGTAATAGATAATAAATCTGGAAAAGTTACAGCTTATG
ATTTACTTAGCAATCGAGTAATCAAGAAACCCATGTCAGCAAGTGCTCTTTTTGTTCAAGATCATCGTCCTCAGTTTCTCATAGAAAATC
CTAAGACTAGTTTAGAGGATGCAACACTACAAATTGAAGAACTGTGGAAGACATTGAGTGAAGAGGAAAAACTGAAATATGAAGAGAAGG
CTACTAAAGACTTGGAACGATACAATAGTCAAATGAAGAGAGCCATTGAACAGGAGTCACAAATGTCACTAAAAGATGGCAGAAAAAAGA
TAAAACCCACCAGCGCATGGAATTTGGCCCAGAAGCACAAGTTAAAAACCTCATTATCTAATCAACCAAAACTTGATGAACTCCTTCAGT
CCCAAATTGAAAAAAGAAGGAGTCAAAATATTAAAATGGTACAGATCCCCTTTTCTATGAAAAACTTAAAAATAAATTTTAAGAAACAAA
ACAAAGTTGACTTAGAAGAGAAGGATGAACCTTGCTTGATCCACAATCTCAGGTTTCCTGATGCATGGCTAATGACATCCAAAACAGAGG
TAATGTTATTAAATCCATATAGAGTAGAAGAAGCCCTGCTATTTAAAAGACTTCTTGAGAATCATAAACTTCCTGCAGAGCCACTGGAAA
AGCCAATTATGTTAACAGAGAGTCTTTTTAATGGATCTCATTATTTAGACGTTTTATATAAAATGACAGCAGATGACCAAAGATACAGTG
GATCAACTTACCTGTCTGATCCTCGTCTTACAGCGAATGGTTTCAAGATAAAATTGATACCAGGAGTTTCAATTACTGAAAATTACTTGG
AAATAGAAGGAATGGCTAATTGTCTCCCATTCTATGGAGTAGCAGATTTAAAAGAAATTCTTAATGCTATATTAAACAGAAATGCAAAGG
AAGTTTATGAATGTAGACCTCGCAAAGTGATAAGTTATTTAGAGGGAGAAGCAGTGCGTCTATCCAGACAATTACCCATGTACTTATCAA
AAGAGGACATCCAAGACATTATCTACAGAATGAAGCACCAGTTTGGAAATGAAATTAAAGAGTGTGTTCATGGTCGCCCATTTTTTCATC
ATTTAACCTATCTTCCAGAAACTACATGATTAAATATGTTTAAGAAGATTAGTTACCATTGAAATTGGTTCTGTCATAAAACAGCATGAG
TCTGGTTTTAAATTATCTTTGTATTATGTGTCACATGGTTATTTTTTAAATGAGGATTCACTGACTTGTTTTTATATTGAAAAAAGTTCC

>7194_7194_2_ASNSD1-PMS1_ASNSD1_chr2_190526336_ENST00000607535_PMS1_chr2_190708690_ENST00000441310_length(amino acids)=773AA_BP=1
MRSVEMPSRGTRPEDSSVLIPTDNSTPHKEDLSSKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSF
TSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGP
LPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNID
KNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILV
PEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELW
KTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQI
PFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYL
DVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEG

--------------------------------------------------------------
>7194_7194_3_ASNSD1-PMS1_ASNSD1_chr2_190526336_ENST00000607690_PMS1_chr2_190708690_ENST00000418224_length(transcript)=2498nt_BP=90nt
ATGCCCAGCCGAGGGACGCGACCAGAGGACAGCTCTGTGCTGATCCCCACCGACAATTCGACCCCACACAAGGAGGATCTAAGCAGCAAG
GCAGTTATTTGGCAGAAAAGCAGAGTATCAGATCACAAGATGGCTCTCATGTCAGTTCTGGGGACTGCTGTTATGAACAATATGGAATCC
TTTCAGTACCACTCTGAAGAATCTCAGATTTATCTCAGTGGATTTCTTCCAAAGTGTGATGCAGACCACTCTTTCACTAGTCTTTCAACA
CCAGAAAGAAGTTTCATCTTCATAAACAGTCGACCAGTACATCAAAAAGATATCTTAAAGTTAATCCGACATCATTACAATCTGAAATGC
CTAAAGGAATCTACTCGTTTGTATCCTGTTTTCTTTCTGAAAATCGATGTTCCTACAGCTGATGTTGATGTAAATTTAACACCAGATAAA
AGCCAAGTATTATTACAAAATAAGGAATCTGTTTTAATTGCTCTTGAAAATCTGATGACGACTTGTTATGGACCATTACCTAGTACAAAT
TCTTATGAAAATAATAAAACAGATGTTTCCGCAGCTGACATCGTTCTTAGTAAAACAGCAGAAACAGATGTGCTTTTTAATAAAGTGGAA
TCATCTGGAAAGAATTATTCAAATGTTGATACTTCAGTCATTCCATTCCAAAATGATATGCATAATGATGAATCTGGAAAAAACACTGAT
GATTGTTTAAATCACCAGATAAGTATTGGTGACTTTGGTTATGGTCATTGTAGTAGTGAAATTTCTAACATTGATAAAAACACTAAGAAT
GCATTTCAGGACATTTCAATGAGTAATGTATCATGGGAGAACTCTCAGACGGAATATAGTAAAACTTGTTTTATAAGTTCCGTTAAGCAC
ACCCAGTCAGAAAATGGCAATAAAGACCATATAGATGAGAGTGGGGAAAATGAGGAAGAAGCAGGTCTTGAAAACTCTTCGGAAATTTCT
GCAGATGAGTGGAGCAGGGGAAATATACTTAAAAATTCAGTGGGAGAGAATATTGAACCTGTGAAAATTTTAGTGCCTGAAAAAAGTTTA
CCATGTAAAGTAAGTAATAATAATTATCCAATCCCTGAACAAATGAATCTTAATGAAGATTCATGTAACAAAAAATCAAATGTAATAGAT
AATAAATCTGGAAAAGTTACAGCTTATGATTTACTTAGCAATCGAGTAATCAAGAAACCCATGTCAGCAAGTGCTCTTTTTGTTCAAGAT
CATCGTCCTCAGTTTCTCATAGAAAATCCTAAGACTAGTTTAGAGGATGCAACACTACAAATTGAAGAACTGTGGAAGACATTGAGTGAA
GAGGAAAAACTGAAATATGAAGAGAAGGCTACTAAAGACTTGGAACGATACAATAGTCAAATGAAGAGAGCCATTGAACAGGAGTCACAA
ATGTCACTAAAAGATGGCAGAAAAAAGATAAAACCCACCAGCGCATGGAATTTGGCCCAGAAGCACAAGTTAAAAACCTCATTATCTAAT
CAACCAAAACTTGATGAACTCCTTCAGTCCCAAATTGAAAAAAGAAGGAGTCAAAATATTAAAATGGTACAGATCCCCTTTTCTATGAAA
AACTTAAAAATAAATTTTAAGAAACAAAACAAAGTTGACTTAGAAGAGAAGGATGAACCTTGCTTGATCCACAATCTCAGGTTTCCTGAT
GCATGGCTAATGACATCCAAAACAGAGGTAATGTTATTAAATCCATATAGAGTAGAAGAAGCCCTGCTATTTAAAAGACTTCTTGAGAAT
CATAAACTTCCTGCAGAGCCACTGGAAAAGCCAATTATGTTAACAGAGAGTCTTTTTAATGGATCTCATTATTTAGACGTTTTATATAAA
ATGACAGCAGATGACCAAAGATACAGTGGATCAACTTACCTGTCTGATCCTCGTCTTACAGCGAATGGTTTCAAGATAAAATTGATACCA
GGAGTTTCAATTACTGAAAATTACTTGGAAATAGAAGGAATGGCTAATTGTCTCCCATTCTATGGAGTAGCAGATTTAAAAGAAATTCTT
AATGCTATATTAAACAGAAATGCAAAGGAAGTTTATGAATGTAGACCTCGCAAAGTGATAAGTTATTTAGAGGGAGAAGCAGTGCGTCTA
TCCAGACAATTACCCATGTACTTATCAAAAGAGGACATCCAAGACATTATCTACAGAATGAAGCACCAGTTTGGAAATGAAATTAAAGAG
TGTGTTCATGGTCGCCCATTTTTTCATCATTTAACCTATCTTCCAGAAACTACATGATTAAATATGTTTAAGAAGATTAGTTACCATTGA
AATTGGTTCTGTCATAAAACAGCATGAGTCTGGTTTTAAATTATCTTTGTATTATGTGTCACATGGTTATTTTTTAAATGAGGATTCACT

>7194_7194_3_ASNSD1-PMS1_ASNSD1_chr2_190526336_ENST00000607690_PMS1_chr2_190708690_ENST00000418224_length(amino acids)=768AA_BP=0
MPSRGTRPEDSSVLIPTDNSTPHKEDLSSKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLST
PERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTN
SYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKN
AFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSL
PCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSE
EEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMK
NLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYK
MTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRL

--------------------------------------------------------------
>7194_7194_4_ASNSD1-PMS1_ASNSD1_chr2_190526336_ENST00000607690_PMS1_chr2_190708690_ENST00000441310_length(transcript)=2500nt_BP=90nt
ATGCCCAGCCGAGGGACGCGACCAGAGGACAGCTCTGTGCTGATCCCCACCGACAATTCGACCCCACACAAGGAGGATCTAAGCAGCAAG
GCAGTTATTTGGCAGAAAAGCAGAGTATCAGATCACAAGATGGCTCTCATGTCAGTTCTGGGGACTGCTGTTATGAACAATATGGAATCC
TTTCAGTACCACTCTGAAGAATCTCAGATTTATCTCAGTGGATTTCTTCCAAAGTGTGATGCAGACCACTCTTTCACTAGTCTTTCAACA
CCAGAAAGAAGTTTCATCTTCATAAACAGTCGACCAGTACATCAAAAAGATATCTTAAAGTTAATCCGACATCATTACAATCTGAAATGC
CTAAAGGAATCTACTCGTTTGTATCCTGTTTTCTTTCTGAAAATCGATGTTCCTACAGCTGATGTTGATGTAAATTTAACACCAGATAAA
AGCCAAGTATTATTACAAAATAAGGAATCTGTTTTAATTGCTCTTGAAAATCTGATGACGACTTGTTATGGACCATTACCTAGTACAAAT
TCTTATGAAAATAATAAAACAGATGTTTCCGCAGCTGACATCGTTCTTAGTAAAACAGCAGAAACAGATGTGCTTTTTAATAAAGTGGAA
TCATCTGGAAAGAATTATTCAAATGTTGATACTTCAGTCATTCCATTCCAAAATGATATGCATAATGATGAATCTGGAAAAAACACTGAT
GATTGTTTAAATCACCAGATAAGTATTGGTGACTTTGGTTATGGTCATTGTAGTAGTGAAATTTCTAACATTGATAAAAACACTAAGAAT
GCATTTCAGGACATTTCAATGAGTAATGTATCATGGGAGAACTCTCAGACGGAATATAGTAAAACTTGTTTTATAAGTTCCGTTAAGCAC
ACCCAGTCAGAAAATGGCAATAAAGACCATATAGATGAGAGTGGGGAAAATGAGGAAGAAGCAGGTCTTGAAAACTCTTCGGAAATTTCT
GCAGATGAGTGGAGCAGGGGAAATATACTTAAAAATTCAGTGGGAGAGAATATTGAACCTGTGAAAATTTTAGTGCCTGAAAAAAGTTTA
CCATGTAAAGTAAGTAATAATAATTATCCAATCCCTGAACAAATGAATCTTAATGAAGATTCATGTAACAAAAAATCAAATGTAATAGAT
AATAAATCTGGAAAAGTTACAGCTTATGATTTACTTAGCAATCGAGTAATCAAGAAACCCATGTCAGCAAGTGCTCTTTTTGTTCAAGAT
CATCGTCCTCAGTTTCTCATAGAAAATCCTAAGACTAGTTTAGAGGATGCAACACTACAAATTGAAGAACTGTGGAAGACATTGAGTGAA
GAGGAAAAACTGAAATATGAAGAGAAGGCTACTAAAGACTTGGAACGATACAATAGTCAAATGAAGAGAGCCATTGAACAGGAGTCACAA
ATGTCACTAAAAGATGGCAGAAAAAAGATAAAACCCACCAGCGCATGGAATTTGGCCCAGAAGCACAAGTTAAAAACCTCATTATCTAAT
CAACCAAAACTTGATGAACTCCTTCAGTCCCAAATTGAAAAAAGAAGGAGTCAAAATATTAAAATGGTACAGATCCCCTTTTCTATGAAA
AACTTAAAAATAAATTTTAAGAAACAAAACAAAGTTGACTTAGAAGAGAAGGATGAACCTTGCTTGATCCACAATCTCAGGTTTCCTGAT
GCATGGCTAATGACATCCAAAACAGAGGTAATGTTATTAAATCCATATAGAGTAGAAGAAGCCCTGCTATTTAAAAGACTTCTTGAGAAT
CATAAACTTCCTGCAGAGCCACTGGAAAAGCCAATTATGTTAACAGAGAGTCTTTTTAATGGATCTCATTATTTAGACGTTTTATATAAA
ATGACAGCAGATGACCAAAGATACAGTGGATCAACTTACCTGTCTGATCCTCGTCTTACAGCGAATGGTTTCAAGATAAAATTGATACCA
GGAGTTTCAATTACTGAAAATTACTTGGAAATAGAAGGAATGGCTAATTGTCTCCCATTCTATGGAGTAGCAGATTTAAAAGAAATTCTT
AATGCTATATTAAACAGAAATGCAAAGGAAGTTTATGAATGTAGACCTCGCAAAGTGATAAGTTATTTAGAGGGAGAAGCAGTGCGTCTA
TCCAGACAATTACCCATGTACTTATCAAAAGAGGACATCCAAGACATTATCTACAGAATGAAGCACCAGTTTGGAAATGAAATTAAAGAG
TGTGTTCATGGTCGCCCATTTTTTCATCATTTAACCTATCTTCCAGAAACTACATGATTAAATATGTTTAAGAAGATTAGTTACCATTGA
AATTGGTTCTGTCATAAAACAGCATGAGTCTGGTTTTAAATTATCTTTGTATTATGTGTCACATGGTTATTTTTTAAATGAGGATTCACT

>7194_7194_4_ASNSD1-PMS1_ASNSD1_chr2_190526336_ENST00000607690_PMS1_chr2_190708690_ENST00000441310_length(amino acids)=768AA_BP=0
MPSRGTRPEDSSVLIPTDNSTPHKEDLSSKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLST
PERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTN
SYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKN
AFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSL
PCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSE
EEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMK
NLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYK
MTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRL

--------------------------------------------------------------
>7194_7194_5_ASNSD1-PMS1_ASNSD1_chr2_190526336_ENST00000607829_PMS1_chr2_190708690_ENST00000418224_length(transcript)=2498nt_BP=90nt
ATGCCCAGCCGAGGGACGCGACCAGAGGACAGCTCTGTGCTGATCCCCACCGACAATTCGACCCCACACAAGGAGGATCTAAGCAGCAAG
GCAGTTATTTGGCAGAAAAGCAGAGTATCAGATCACAAGATGGCTCTCATGTCAGTTCTGGGGACTGCTGTTATGAACAATATGGAATCC
TTTCAGTACCACTCTGAAGAATCTCAGATTTATCTCAGTGGATTTCTTCCAAAGTGTGATGCAGACCACTCTTTCACTAGTCTTTCAACA
CCAGAAAGAAGTTTCATCTTCATAAACAGTCGACCAGTACATCAAAAAGATATCTTAAAGTTAATCCGACATCATTACAATCTGAAATGC
CTAAAGGAATCTACTCGTTTGTATCCTGTTTTCTTTCTGAAAATCGATGTTCCTACAGCTGATGTTGATGTAAATTTAACACCAGATAAA
AGCCAAGTATTATTACAAAATAAGGAATCTGTTTTAATTGCTCTTGAAAATCTGATGACGACTTGTTATGGACCATTACCTAGTACAAAT
TCTTATGAAAATAATAAAACAGATGTTTCCGCAGCTGACATCGTTCTTAGTAAAACAGCAGAAACAGATGTGCTTTTTAATAAAGTGGAA
TCATCTGGAAAGAATTATTCAAATGTTGATACTTCAGTCATTCCATTCCAAAATGATATGCATAATGATGAATCTGGAAAAAACACTGAT
GATTGTTTAAATCACCAGATAAGTATTGGTGACTTTGGTTATGGTCATTGTAGTAGTGAAATTTCTAACATTGATAAAAACACTAAGAAT
GCATTTCAGGACATTTCAATGAGTAATGTATCATGGGAGAACTCTCAGACGGAATATAGTAAAACTTGTTTTATAAGTTCCGTTAAGCAC
ACCCAGTCAGAAAATGGCAATAAAGACCATATAGATGAGAGTGGGGAAAATGAGGAAGAAGCAGGTCTTGAAAACTCTTCGGAAATTTCT
GCAGATGAGTGGAGCAGGGGAAATATACTTAAAAATTCAGTGGGAGAGAATATTGAACCTGTGAAAATTTTAGTGCCTGAAAAAAGTTTA
CCATGTAAAGTAAGTAATAATAATTATCCAATCCCTGAACAAATGAATCTTAATGAAGATTCATGTAACAAAAAATCAAATGTAATAGAT
AATAAATCTGGAAAAGTTACAGCTTATGATTTACTTAGCAATCGAGTAATCAAGAAACCCATGTCAGCAAGTGCTCTTTTTGTTCAAGAT
CATCGTCCTCAGTTTCTCATAGAAAATCCTAAGACTAGTTTAGAGGATGCAACACTACAAATTGAAGAACTGTGGAAGACATTGAGTGAA
GAGGAAAAACTGAAATATGAAGAGAAGGCTACTAAAGACTTGGAACGATACAATAGTCAAATGAAGAGAGCCATTGAACAGGAGTCACAA
ATGTCACTAAAAGATGGCAGAAAAAAGATAAAACCCACCAGCGCATGGAATTTGGCCCAGAAGCACAAGTTAAAAACCTCATTATCTAAT
CAACCAAAACTTGATGAACTCCTTCAGTCCCAAATTGAAAAAAGAAGGAGTCAAAATATTAAAATGGTACAGATCCCCTTTTCTATGAAA
AACTTAAAAATAAATTTTAAGAAACAAAACAAAGTTGACTTAGAAGAGAAGGATGAACCTTGCTTGATCCACAATCTCAGGTTTCCTGAT
GCATGGCTAATGACATCCAAAACAGAGGTAATGTTATTAAATCCATATAGAGTAGAAGAAGCCCTGCTATTTAAAAGACTTCTTGAGAAT
CATAAACTTCCTGCAGAGCCACTGGAAAAGCCAATTATGTTAACAGAGAGTCTTTTTAATGGATCTCATTATTTAGACGTTTTATATAAA
ATGACAGCAGATGACCAAAGATACAGTGGATCAACTTACCTGTCTGATCCTCGTCTTACAGCGAATGGTTTCAAGATAAAATTGATACCA
GGAGTTTCAATTACTGAAAATTACTTGGAAATAGAAGGAATGGCTAATTGTCTCCCATTCTATGGAGTAGCAGATTTAAAAGAAATTCTT
AATGCTATATTAAACAGAAATGCAAAGGAAGTTTATGAATGTAGACCTCGCAAAGTGATAAGTTATTTAGAGGGAGAAGCAGTGCGTCTA
TCCAGACAATTACCCATGTACTTATCAAAAGAGGACATCCAAGACATTATCTACAGAATGAAGCACCAGTTTGGAAATGAAATTAAAGAG
TGTGTTCATGGTCGCCCATTTTTTCATCATTTAACCTATCTTCCAGAAACTACATGATTAAATATGTTTAAGAAGATTAGTTACCATTGA
AATTGGTTCTGTCATAAAACAGCATGAGTCTGGTTTTAAATTATCTTTGTATTATGTGTCACATGGTTATTTTTTAAATGAGGATTCACT

>7194_7194_5_ASNSD1-PMS1_ASNSD1_chr2_190526336_ENST00000607829_PMS1_chr2_190708690_ENST00000418224_length(amino acids)=768AA_BP=0
MPSRGTRPEDSSVLIPTDNSTPHKEDLSSKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLST
PERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTN
SYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKN
AFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSL
PCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSE
EEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMK
NLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYK
MTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRL

--------------------------------------------------------------
>7194_7194_6_ASNSD1-PMS1_ASNSD1_chr2_190526336_ENST00000607829_PMS1_chr2_190708690_ENST00000441310_length(transcript)=2500nt_BP=90nt
ATGCCCAGCCGAGGGACGCGACCAGAGGACAGCTCTGTGCTGATCCCCACCGACAATTCGACCCCACACAAGGAGGATCTAAGCAGCAAG
GCAGTTATTTGGCAGAAAAGCAGAGTATCAGATCACAAGATGGCTCTCATGTCAGTTCTGGGGACTGCTGTTATGAACAATATGGAATCC
TTTCAGTACCACTCTGAAGAATCTCAGATTTATCTCAGTGGATTTCTTCCAAAGTGTGATGCAGACCACTCTTTCACTAGTCTTTCAACA
CCAGAAAGAAGTTTCATCTTCATAAACAGTCGACCAGTACATCAAAAAGATATCTTAAAGTTAATCCGACATCATTACAATCTGAAATGC
CTAAAGGAATCTACTCGTTTGTATCCTGTTTTCTTTCTGAAAATCGATGTTCCTACAGCTGATGTTGATGTAAATTTAACACCAGATAAA
AGCCAAGTATTATTACAAAATAAGGAATCTGTTTTAATTGCTCTTGAAAATCTGATGACGACTTGTTATGGACCATTACCTAGTACAAAT
TCTTATGAAAATAATAAAACAGATGTTTCCGCAGCTGACATCGTTCTTAGTAAAACAGCAGAAACAGATGTGCTTTTTAATAAAGTGGAA
TCATCTGGAAAGAATTATTCAAATGTTGATACTTCAGTCATTCCATTCCAAAATGATATGCATAATGATGAATCTGGAAAAAACACTGAT
GATTGTTTAAATCACCAGATAAGTATTGGTGACTTTGGTTATGGTCATTGTAGTAGTGAAATTTCTAACATTGATAAAAACACTAAGAAT
GCATTTCAGGACATTTCAATGAGTAATGTATCATGGGAGAACTCTCAGACGGAATATAGTAAAACTTGTTTTATAAGTTCCGTTAAGCAC
ACCCAGTCAGAAAATGGCAATAAAGACCATATAGATGAGAGTGGGGAAAATGAGGAAGAAGCAGGTCTTGAAAACTCTTCGGAAATTTCT
GCAGATGAGTGGAGCAGGGGAAATATACTTAAAAATTCAGTGGGAGAGAATATTGAACCTGTGAAAATTTTAGTGCCTGAAAAAAGTTTA
CCATGTAAAGTAAGTAATAATAATTATCCAATCCCTGAACAAATGAATCTTAATGAAGATTCATGTAACAAAAAATCAAATGTAATAGAT
AATAAATCTGGAAAAGTTACAGCTTATGATTTACTTAGCAATCGAGTAATCAAGAAACCCATGTCAGCAAGTGCTCTTTTTGTTCAAGAT
CATCGTCCTCAGTTTCTCATAGAAAATCCTAAGACTAGTTTAGAGGATGCAACACTACAAATTGAAGAACTGTGGAAGACATTGAGTGAA
GAGGAAAAACTGAAATATGAAGAGAAGGCTACTAAAGACTTGGAACGATACAATAGTCAAATGAAGAGAGCCATTGAACAGGAGTCACAA
ATGTCACTAAAAGATGGCAGAAAAAAGATAAAACCCACCAGCGCATGGAATTTGGCCCAGAAGCACAAGTTAAAAACCTCATTATCTAAT
CAACCAAAACTTGATGAACTCCTTCAGTCCCAAATTGAAAAAAGAAGGAGTCAAAATATTAAAATGGTACAGATCCCCTTTTCTATGAAA
AACTTAAAAATAAATTTTAAGAAACAAAACAAAGTTGACTTAGAAGAGAAGGATGAACCTTGCTTGATCCACAATCTCAGGTTTCCTGAT
GCATGGCTAATGACATCCAAAACAGAGGTAATGTTATTAAATCCATATAGAGTAGAAGAAGCCCTGCTATTTAAAAGACTTCTTGAGAAT
CATAAACTTCCTGCAGAGCCACTGGAAAAGCCAATTATGTTAACAGAGAGTCTTTTTAATGGATCTCATTATTTAGACGTTTTATATAAA
ATGACAGCAGATGACCAAAGATACAGTGGATCAACTTACCTGTCTGATCCTCGTCTTACAGCGAATGGTTTCAAGATAAAATTGATACCA
GGAGTTTCAATTACTGAAAATTACTTGGAAATAGAAGGAATGGCTAATTGTCTCCCATTCTATGGAGTAGCAGATTTAAAAGAAATTCTT
AATGCTATATTAAACAGAAATGCAAAGGAAGTTTATGAATGTAGACCTCGCAAAGTGATAAGTTATTTAGAGGGAGAAGCAGTGCGTCTA
TCCAGACAATTACCCATGTACTTATCAAAAGAGGACATCCAAGACATTATCTACAGAATGAAGCACCAGTTTGGAAATGAAATTAAAGAG
TGTGTTCATGGTCGCCCATTTTTTCATCATTTAACCTATCTTCCAGAAACTACATGATTAAATATGTTTAAGAAGATTAGTTACCATTGA
AATTGGTTCTGTCATAAAACAGCATGAGTCTGGTTTTAAATTATCTTTGTATTATGTGTCACATGGTTATTTTTTAAATGAGGATTCACT

>7194_7194_6_ASNSD1-PMS1_ASNSD1_chr2_190526336_ENST00000607829_PMS1_chr2_190708690_ENST00000441310_length(amino acids)=768AA_BP=0
MPSRGTRPEDSSVLIPTDNSTPHKEDLSSKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLST
PERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTN
SYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKN
AFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSL
PCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSE
EEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMK
NLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYK
MTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ASNSD1-PMS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASNSD1-PMS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASNSD1-PMS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource