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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RALGAPB-RPRD1B (FusionGDB2 ID:71945)

Fusion Gene Summary for RALGAPB-RPRD1B

check button Fusion gene summary
Fusion gene informationFusion gene name: RALGAPB-RPRD1B
Fusion gene ID: 71945
HgeneTgene
Gene symbol

RALGAPB

RPRD1B

Gene ID

57148

58490

Gene nameRal GTPase activating protein non-catalytic subunit betaregulation of nuclear pre-mRNA domain containing 1B
SynonymsKIAA1219|RalGAPbetaC20orf77|CREPT|K-H|Kub5-Hera|NET60|dJ1057B20.2
Cytomap

20q11.23

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionral GTPase-activating protein subunit betaRal GTPase activating protein non-catalytic beta subunitRal GTPase activating protein, beta subunit (non-catalytic)regulation of nuclear pre-mRNA domain-containing protein 1BKu70-binding protein 5-Heracell-cycle related and expression-elevated protein in tumor
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262879, ENST00000397038, 
ENST00000397040, ENST00000397042, 
ENST00000537204, ENST00000490114, 
ENST00000471511, ENST00000373433, 
Fusion gene scores* DoF score12 X 12 X 9=12968 X 7 X 5=280
# samples 149
** MAII scorelog2(14/1296*10)=-3.21056698593966
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RALGAPB [Title/Abstract] AND RPRD1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRALGAPB(37145013)-RPRD1B(36694483), # samples:2
RALGAPB(37137851)-RPRD1B(36694483), # samples:2
Anticipated loss of major functional domain due to fusion event.RALGAPB-RPRD1B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPRD1B

GO:0008284

positive regulation of cell proliferation

22264791

TgeneRPRD1B

GO:0010564

regulation of cell cycle process

22264791

TgeneRPRD1B

GO:0045944

positive regulation of transcription by RNA polymerase II

22264791


check buttonFusion gene breakpoints across RALGAPB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPRD1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1FC-01ARALGAPBchr20

37137851

-RPRD1Bchr20

36694483

+
ChimerDB4BRCATCGA-BH-A1FC-01ARALGAPBchr20

37137851

+RPRD1Bchr20

36694483

+
ChimerDB4BRCATCGA-BH-A1FC-01ARALGAPBchr20

37145013

+RPRD1Bchr20

36694483

+


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Fusion Gene ORF analysis for RALGAPB-RPRD1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262879ENST00000471511RALGAPBchr20

37137851

+RPRD1Bchr20

36694483

+
5CDS-intronENST00000262879ENST00000471511RALGAPBchr20

37145013

+RPRD1Bchr20

36694483

+
5CDS-intronENST00000397038ENST00000471511RALGAPBchr20

37137851

+RPRD1Bchr20

36694483

+
5CDS-intronENST00000397038ENST00000471511RALGAPBchr20

37145013

+RPRD1Bchr20

36694483

+
5CDS-intronENST00000397040ENST00000471511RALGAPBchr20

37137851

+RPRD1Bchr20

36694483

+
5CDS-intronENST00000397040ENST00000471511RALGAPBchr20

37145013

+RPRD1Bchr20

36694483

+
5CDS-intronENST00000397042ENST00000471511RALGAPBchr20

37137851

+RPRD1Bchr20

36694483

+
5CDS-intronENST00000397042ENST00000471511RALGAPBchr20

37145013

+RPRD1Bchr20

36694483

+
5CDS-intronENST00000537204ENST00000471511RALGAPBchr20

37137851

+RPRD1Bchr20

36694483

+
5CDS-intronENST00000537204ENST00000471511RALGAPBchr20

37145013

+RPRD1Bchr20

36694483

+
Frame-shiftENST00000262879ENST00000373433RALGAPBchr20

37137851

+RPRD1Bchr20

36694483

+
Frame-shiftENST00000397038ENST00000373433RALGAPBchr20

37137851

+RPRD1Bchr20

36694483

+
Frame-shiftENST00000397040ENST00000373433RALGAPBchr20

37137851

+RPRD1Bchr20

36694483

+
Frame-shiftENST00000397042ENST00000373433RALGAPBchr20

37137851

+RPRD1Bchr20

36694483

+
Frame-shiftENST00000537204ENST00000373433RALGAPBchr20

37137851

+RPRD1Bchr20

36694483

+
In-frameENST00000262879ENST00000373433RALGAPBchr20

37145013

+RPRD1Bchr20

36694483

+
In-frameENST00000397038ENST00000373433RALGAPBchr20

37145013

+RPRD1Bchr20

36694483

+
In-frameENST00000397040ENST00000373433RALGAPBchr20

37145013

+RPRD1Bchr20

36694483

+
In-frameENST00000397042ENST00000373433RALGAPBchr20

37145013

+RPRD1Bchr20

36694483

+
In-frameENST00000537204ENST00000373433RALGAPBchr20

37145013

+RPRD1Bchr20

36694483

+
intron-3CDSENST00000490114ENST00000373433RALGAPBchr20

37137851

+RPRD1Bchr20

36694483

+
intron-3CDSENST00000490114ENST00000373433RALGAPBchr20

37145013

+RPRD1Bchr20

36694483

+
intron-intronENST00000490114ENST00000471511RALGAPBchr20

37137851

+RPRD1Bchr20

36694483

+
intron-intronENST00000490114ENST00000471511RALGAPBchr20

37145013

+RPRD1Bchr20

36694483

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262879RALGAPBchr2037145013+ENST00000373433RPRD1Bchr2036694483+415213352661660464
ENST00000397042RALGAPBchr2037145013+ENST00000373433RPRD1Bchr2036694483+415213352661660464
ENST00000397038RALGAPBchr2037145013+ENST00000373433RPRD1Bchr2036694483+412513082391633464
ENST00000537204RALGAPBchr2037145013+ENST00000373433RPRD1Bchr2036694483+411813012321626464
ENST00000397040RALGAPBchr2037145013+ENST00000373433RPRD1Bchr2036694483+39261109401434464

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262879ENST00000373433RALGAPBchr2037145013+RPRD1Bchr2036694483+0.0007137640.99928623
ENST00000397042ENST00000373433RALGAPBchr2037145013+RPRD1Bchr2036694483+0.0007137640.99928623
ENST00000397038ENST00000373433RALGAPBchr2037145013+RPRD1Bchr2036694483+0.0006944350.9993056
ENST00000537204ENST00000373433RALGAPBchr2037145013+RPRD1Bchr2036694483+0.0006993740.9993006
ENST00000397040ENST00000373433RALGAPBchr2037145013+RPRD1Bchr2036694483+0.0005843390.99941564

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Fusion Genomic Features for RALGAPB-RPRD1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RALGAPBchr2037145013+RPRD1Bchr2036694482+7.61E-070.9999993
RALGAPBchr2037137851+RPRD1Bchr2036694482+8.57E-080.9999999
RALGAPBchr2037145013+RPRD1Bchr2036694482+7.61E-070.9999993
RALGAPBchr2037137851+RPRD1Bchr2036694482+8.57E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RALGAPB-RPRD1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:37145013/chr20:36694483)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRALGAPBchr20:37145013chr20:36694483ENST00000262879+7301149_13923501495.0DomainRap-GAP
HgeneRALGAPBchr20:37145013chr20:36694483ENST00000397038+7301149_13921281274.0DomainRap-GAP
HgeneRALGAPBchr20:37145013chr20:36694483ENST00000397040+7301149_13923501495.0DomainRap-GAP
TgeneRPRD1Bchr20:37145013chr20:36694483ENST00000373433472_133218327.0DomainCID


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Fusion Gene Sequence for RALGAPB-RPRD1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71945_71945_1_RALGAPB-RPRD1B_RALGAPB_chr20_37145013_ENST00000262879_RPRD1B_chr20_36694483_ENST00000373433_length(transcript)=4152nt_BP=1335nt
GAGTTATTTGACGCCGCCGCCCCTGGCAGTCGGAAGTTGCCTGAGCAGATCCCAGCCGGCTGGCTCGAGTGGCCTTCGTCGTCCCTTGGC
GCCCTGGGAGAGTCGCTGACGGGTGGACTGACGGACCGCCTGAGGACGGCCGGCCAGGGCGGTGAAAGCGCCAGCCCTATGGCGCGGGTC
GCGTGAGGCGGAAGGCCGAGGACGGCCGGCGGCGGCGCCCGCCCCGGCGATGCGGGCCCCGCCCGTCGCCTCAGGTGCCATTTGGATTGT
ACTTTAGTGGCACGATGTACTCTGAGTGGAGGTCACTGCATTTGGTGATTCAGAATGATCAAGGCCATACCAGTGTGCTGCACAGCTATC
CAGAGAGCGTTGGACGAGAGGTGGCAAATGCTGTAGTCCGTCCTCTTGGGCAGGTGTTAGGTACCCCTTCAGTGGCTGGTAGTGAGAATT
TGTTAAAAACTGACAAAGAAGTAAAATGGACCATGGAAGTAATTTGCTATGGACTGACCCTTCCATTGGATGGAGAGACTGTAAAATATT
GCGTTGATGTATATACAGACTGGATTATGGCTTTAGTGTTGCCAAAAGATTCTATTCCATTGCCAGTTATTAAAGAGCCTAATCAATATG
TTCAAACTATACTAAAACACCTACAGAATCTTTTTGTACCAAGACAGGAACAGGGTTCCAGTCAGATTCGACTATGCTTACAGGTCCTGA
GAGCCATTCAGAAACTGGCCCGTGAGTCATCTCTCATGGCCCGAGAAACTTGGGAAGTCTTACTGTTGTTTCTTCTGCAGATTAACGACA
TACTTCTGGCCCCACCAACTGTTCAAGGTGGCATTGCTGAGAATCTAGCAGAGAAGTTGATTGGTGTTCTCTTTGAGGTGTGGTTACTAG
CTTGTACTCGGTGCTTCCCAACACCTCCTTATTGGAAAACAGCCAAGGAGATGGTGGCTAACTGGAGGCATCACCCAGCAGTGGTGGAGC
AGTGGAGCAAGGTCATTTGTGCACTCACTTCCAGATTGCTACGCTTTACATATGGTCCTTCATTTCCTGCATTTAAAGTTCCCGATGAAG
ATGCCAGTCTGATCCCTCCAGAAATGGATAATGAGTGTGTTGCACAGACATGGTTTCGCTTTTTACACATGTTAAGTAATCCTGTGGATT
TGAGTAACCCAGCTATTATAAGCTCTACTCCCAAATTTCAGGAACAGTTCTTGAATGTGAGCGGAATGCCGCAAGAATTGAATCAGTATC
CCTGCCTTAAACATCTGCCTCAAATATTTTTTCGTGCCATGCGTGGAATCAGCTGTCTGGTGGATGCATTCTTAGACAAAGAGGCAGCTG
AACGTCTTTCAAAAACAGTAGATGAAGCATGTCTGTTACTAGCAGAATATAACGGGCGCCTGGCAGCAGAACTGGAGGACCGTCGCCAGC
TGGCTCGGATGTTGGTGGAGTATACCCAGAATCAGAAAGATGTTTTGTCGGAGAAGGAGAAAAAACTAGAGGAATACAAACAGAAGCTTG
CACGAGTAACCCAGGTCCGCAAGGAACTGAAATCCCATATTCAGAGCTTGCCAGACCTCTCACTGCTGCCCAACGTCACAGGGGGCTTAG
CCCCCCTGCCCTCTGCTGGGGACCTGTTTTCAACTGACTAGGATGGGTGTCATGTCCCAGATTTCTGTTTGTACCAGCAGAAAGAAGAGG
GCAAGTCATGGTTGGAAATAACCTTCTAGCCCCTGGTTCTATCCCTTCTTCCGCCCAGCCCCCCAGCCTCAAGAAAGAACCTCAGACTCT
GATTCTCCTCTTCAGCCTCTCATCTTGAGCACAGTTCAGAACAGTGGCGACTGGAATCTGGTTTATATTCATATTTGCAAAGACTACAGA
CTTTTTCTCCCACTTCATATTTTCATGCCCCCCTGTTGGTTTTCCATTCTTAACTGTCTCCTTATACCTAAGAAGTTATGAAAATCATGT
GTACTTCTGGAAGCTTTCGAAAGAATCTTGTCCCTCATGACAGCATTTTATCATGAAAGCAGCTTCTCCTTTCTGGGCTGGGCTTGTTCA
AGTTCGGTGTGGGCTTCCACTAAGGCACTTGTCCTGGAGACGTTGGCTTTCCCAGCTGCATCTGCCCCAAAAGGTTGTAGGCACAGCTGT
CGTAGCGTTGCCATAAAGAGTTTGCCAAATCTCTGATCCTCCCTTTCCATTGCTTCTCCTAGTGATGCACGAAGATTAGGTGCATTTATT
TTGTAAACAGATTGGAGAATCTAGCAATAAGATTCAAAGCTAATCTGGAGCATAAAGGCACAGTTCAGAGACAGAATAACAGGGATCACA
AGCATGAATTAAAAGGAATTTATTTGCTTCAAGTTCCTAGATACAACCTTCCCATGCTGCACTTCTCCACTGTCGGAGCACGTTCCGAAA
AACAGAATGCCTTGATCCCTGGTGGGTGCGAAGGCAGTTGTTAGGGATGGCAGGCATTGGTGGGCTCCAAAAGATGAAGGCCCCACACAC
AGGTGTGCTGCATTTGGGATCTGTGTGGGTGTTTCTTGGACCCTTTCTTCTGGGAGTAGGGTACACACTAACGTTTAATCCGCTGTCTGG
GTGCATGTCCACAGTACGGTGGCTAAACTCGAACATCACTGCAAATAGGACGCTGAGCAGGTCCGTCTGTCATGTCACGCCACTGCACAG
GTCCTTGTCCCCACACGACGGGGAGTACTTGCGTCAGATGTTATTGAATAGCTCGTCTCGGGCAGGGGAAGCGGGGAGTTGGGGATATTA
ATTGGGGGTTTTAATTCTATTATCATGTCAGCTGACATTATGACTATATAATGTAGTTAGAGACAATTTTTATCTTGCTTATAGTAAAGG
TTCAGCCTGCCAATTGTAAATCATTCTAATTTGGCAGGCTTATTTTTGACATTGGAAAGGGCAGAAAGCGATTTGCCCCAGTAGTGTAAT
AGGAGTTATAGACCAGAGGCTGAAACCCAAACTATATAAAAAGGAATTCAGTGGAGGGGGCTTTGTAATCTCCATTAATTTGTGTTGCTA
CTTCCAGGATCACCAAAAATTACATGTAATTTTACATGTTAAACACATTGAAACATAACCTATGTTTATAAAGCATAACGGGCTTCCCTT
CCAGAAGCTCTCCTGCTTGTCATGAAGTGAGAACAATGAAAAGTCATAGCAGATACTCAGTTTAACTCTGTGTAGAACCTAGTAGTGTTT
GAGCTGTTATTCAGATTTGAATTCAGACTGTGTGTTGTTTGCTTATGGACACTGCCTGTCGTTCTGTCACTGTTAAATTAATGAGTCTAT
AAGGTTTTTCTTCCAGAGGCCATAGGTGACATCACTAAAATTGCAAGATAAATTGTAATCTTTGCTGCTGCTGCACTCCCCAACCTCTCC
CCCACCCCCCGTGGTGTGCTGCTTTCTAGATGAGCGTGTTTTGGAGCAGGCCCATCTGGGACACTCTATGCTTTCACCAAGGAAGTGCGA
TCTGAGCAGCCACAATCCAGCCAAAAGAGGATCGTAGATATTTGCTCTGATCAACTAGATGAAAATATAGCAGAATGGATTTAGCCCACT
GCTCTGTTTTATCCAACTGAGTCTCTGACCAGCAATTGGTGCATAATTATTACAGCAAAAGTTAAGAAATGAAACTGTAGCAATTATGTA
AATGAATGTGTTGGCCTCTTAATACCTGTTACTAGTGGACTTCCTGTGAGGAAGTTAGTTTTTTGTTTTGATGAAATGCTTTCGTTTTTT
AAATCTTAATTCTGCTGTCCACATCCTCCCAAAGTGTGCTTACTTCATTTGTTTAATTTAAATGAACTTTCCTCCTTGTATGTATGAGGT
GACTTGGTGGGTGGGGTGGGTGGTTTTTGTTTTTGTGTTTTTTCTTTCTTAGGGCATCTGTAGGCCTCAAAGGACCTTTCCTTTAGGTCA
TATTCCTCAGAAAGTCTTCAATCTTCCCTTGTTTTTGTTTGTTTGTTTTTCTTAAAGAATATTTTCAAAGCTTAAATTTGTATATTAATT
TAGGACTATTTAGAAGTATAGGCTGTCGTTGGCGGCAGCAGTATATTCTGAAATGTCTCATAGATATATATTTTTGAATAAAGATGGTGT

>71945_71945_1_RALGAPB-RPRD1B_RALGAPB_chr20_37145013_ENST00000262879_RPRD1B_chr20_36694483_ENST00000373433_length(amino acids)=464AA_BP=348
MYFSGTMYSEWRSLHLVIQNDQGHTSVLHSYPESVGREVANAVVRPLGQVLGTPSVAGSENLLKTDKEVKWTMEVICYGLTLPLDGETVK
YCVDVYTDWIMALVLPKDSIPLPVIKEPNQYVQTILKHLQNLFVPRQEQGSSQIRLCLQVLRAIQKLARESSLMARETWEVLLLFLLQIN
DILLAPPTVQGGIAENLAEKLIGVLFEVWLLACTRCFPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTYGPSFPAFKVPD
EDASLIPPEMDNECVAQTWFRFLHMLSNPVDLSNPAIISSTPKFQEQFLNVSGMPQELNQYPCLKHLPQIFFRAMRGISCLVDAFLDKEA
AERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLSLLPNVTGG

--------------------------------------------------------------
>71945_71945_2_RALGAPB-RPRD1B_RALGAPB_chr20_37145013_ENST00000397038_RPRD1B_chr20_36694483_ENST00000373433_length(transcript)=4125nt_BP=1308nt
AGTCGGAAGTTGCCTGAGCAGATCCCAGCCGGCTGGCTCGAGTGGCCTTCGTCGTCCCTTGGCGCCCTGGGAGAGTCGCTGACGGGTGGA
CTGACGGACCGCCTGAGGACGGCCGGCCAGGGCGGTGAAAGCGCCAGCCCTATGGCGCGGGTCGCGTGAGGCGGAAGGCCGAGGACGGCC
GGCGGCGGCGCCCGCCCCGGCGATGCGGGCCCCGCCCGTCGCCTCAGGTGCCATTTGGATTGTACTTTAGTGGCACGATGTACTCTGAGT
GGAGGTCACTGCATTTGGTGATTCAGAATGATCAAGGCCATACCAGTGTGCTGCACAGCTATCCAGAGAGCGTTGGACGAGAGGTGGCAA
ATGCTGTAGTCCGTCCTCTTGGGCAGGTGTTAGGTACCCCTTCAGTGGCTGGTAGTGAGAATTTGTTAAAAACTGACAAAGAAGTAAAAT
GGACCATGGAAGTAATTTGCTATGGACTGACCCTTCCATTGGATGGAGAGACTGTAAAATATTGCGTTGATGTATATACAGACTGGATTA
TGGCTTTAGTGTTGCCAAAAGATTCTATTCCATTGCCAGTTATTAAAGAGCCTAATCAATATGTTCAAACTATACTAAAACACCTACAGA
ATCTTTTTGTACCAAGACAGGAACAGGGTTCCAGTCAGATTCGACTATGCTTACAGGTCCTGAGAGCCATTCAGAAACTGGCCCGTGAGT
CATCTCTCATGGCCCGAGAAACTTGGGAAGTCTTACTGTTGTTTCTTCTGCAGATTAACGACATACTTCTGGCCCCACCAACTGTTCAAG
GTGGCATTGCTGAGAATCTAGCAGAGAAGTTGATTGGTGTTCTCTTTGAGGTGTGGTTACTAGCTTGTACTCGGTGCTTCCCAACACCTC
CTTATTGGAAAACAGCCAAGGAGATGGTGGCTAACTGGAGGCATCACCCAGCAGTGGTGGAGCAGTGGAGCAAGGTCATTTGTGCACTCA
CTTCCAGATTGCTACGCTTTACATATGGTCCTTCATTTCCTGCATTTAAAGTTCCCGATGAAGATGCCAGTCTGATCCCTCCAGAAATGG
ATAATGAGTGTGTTGCACAGACATGGTTTCGCTTTTTACACATGTTAAGTAATCCTGTGGATTTGAGTAACCCAGCTATTATAAGCTCTA
CTCCCAAATTTCAGGAACAGTTCTTGAATGTGAGCGGAATGCCGCAAGAATTGAATCAGTATCCCTGCCTTAAACATCTGCCTCAAATAT
TTTTTCGTGCCATGCGTGGAATCAGCTGTCTGGTGGATGCATTCTTAGACAAAGAGGCAGCTGAACGTCTTTCAAAAACAGTAGATGAAG
CATGTCTGTTACTAGCAGAATATAACGGGCGCCTGGCAGCAGAACTGGAGGACCGTCGCCAGCTGGCTCGGATGTTGGTGGAGTATACCC
AGAATCAGAAAGATGTTTTGTCGGAGAAGGAGAAAAAACTAGAGGAATACAAACAGAAGCTTGCACGAGTAACCCAGGTCCGCAAGGAAC
TGAAATCCCATATTCAGAGCTTGCCAGACCTCTCACTGCTGCCCAACGTCACAGGGGGCTTAGCCCCCCTGCCCTCTGCTGGGGACCTGT
TTTCAACTGACTAGGATGGGTGTCATGTCCCAGATTTCTGTTTGTACCAGCAGAAAGAAGAGGGCAAGTCATGGTTGGAAATAACCTTCT
AGCCCCTGGTTCTATCCCTTCTTCCGCCCAGCCCCCCAGCCTCAAGAAAGAACCTCAGACTCTGATTCTCCTCTTCAGCCTCTCATCTTG
AGCACAGTTCAGAACAGTGGCGACTGGAATCTGGTTTATATTCATATTTGCAAAGACTACAGACTTTTTCTCCCACTTCATATTTTCATG
CCCCCCTGTTGGTTTTCCATTCTTAACTGTCTCCTTATACCTAAGAAGTTATGAAAATCATGTGTACTTCTGGAAGCTTTCGAAAGAATC
TTGTCCCTCATGACAGCATTTTATCATGAAAGCAGCTTCTCCTTTCTGGGCTGGGCTTGTTCAAGTTCGGTGTGGGCTTCCACTAAGGCA
CTTGTCCTGGAGACGTTGGCTTTCCCAGCTGCATCTGCCCCAAAAGGTTGTAGGCACAGCTGTCGTAGCGTTGCCATAAAGAGTTTGCCA
AATCTCTGATCCTCCCTTTCCATTGCTTCTCCTAGTGATGCACGAAGATTAGGTGCATTTATTTTGTAAACAGATTGGAGAATCTAGCAA
TAAGATTCAAAGCTAATCTGGAGCATAAAGGCACAGTTCAGAGACAGAATAACAGGGATCACAAGCATGAATTAAAAGGAATTTATTTGC
TTCAAGTTCCTAGATACAACCTTCCCATGCTGCACTTCTCCACTGTCGGAGCACGTTCCGAAAAACAGAATGCCTTGATCCCTGGTGGGT
GCGAAGGCAGTTGTTAGGGATGGCAGGCATTGGTGGGCTCCAAAAGATGAAGGCCCCACACACAGGTGTGCTGCATTTGGGATCTGTGTG
GGTGTTTCTTGGACCCTTTCTTCTGGGAGTAGGGTACACACTAACGTTTAATCCGCTGTCTGGGTGCATGTCCACAGTACGGTGGCTAAA
CTCGAACATCACTGCAAATAGGACGCTGAGCAGGTCCGTCTGTCATGTCACGCCACTGCACAGGTCCTTGTCCCCACACGACGGGGAGTA
CTTGCGTCAGATGTTATTGAATAGCTCGTCTCGGGCAGGGGAAGCGGGGAGTTGGGGATATTAATTGGGGGTTTTAATTCTATTATCATG
TCAGCTGACATTATGACTATATAATGTAGTTAGAGACAATTTTTATCTTGCTTATAGTAAAGGTTCAGCCTGCCAATTGTAAATCATTCT
AATTTGGCAGGCTTATTTTTGACATTGGAAAGGGCAGAAAGCGATTTGCCCCAGTAGTGTAATAGGAGTTATAGACCAGAGGCTGAAACC
CAAACTATATAAAAAGGAATTCAGTGGAGGGGGCTTTGTAATCTCCATTAATTTGTGTTGCTACTTCCAGGATCACCAAAAATTACATGT
AATTTTACATGTTAAACACATTGAAACATAACCTATGTTTATAAAGCATAACGGGCTTCCCTTCCAGAAGCTCTCCTGCTTGTCATGAAG
TGAGAACAATGAAAAGTCATAGCAGATACTCAGTTTAACTCTGTGTAGAACCTAGTAGTGTTTGAGCTGTTATTCAGATTTGAATTCAGA
CTGTGTGTTGTTTGCTTATGGACACTGCCTGTCGTTCTGTCACTGTTAAATTAATGAGTCTATAAGGTTTTTCTTCCAGAGGCCATAGGT
GACATCACTAAAATTGCAAGATAAATTGTAATCTTTGCTGCTGCTGCACTCCCCAACCTCTCCCCCACCCCCCGTGGTGTGCTGCTTTCT
AGATGAGCGTGTTTTGGAGCAGGCCCATCTGGGACACTCTATGCTTTCACCAAGGAAGTGCGATCTGAGCAGCCACAATCCAGCCAAAAG
AGGATCGTAGATATTTGCTCTGATCAACTAGATGAAAATATAGCAGAATGGATTTAGCCCACTGCTCTGTTTTATCCAACTGAGTCTCTG
ACCAGCAATTGGTGCATAATTATTACAGCAAAAGTTAAGAAATGAAACTGTAGCAATTATGTAAATGAATGTGTTGGCCTCTTAATACCT
GTTACTAGTGGACTTCCTGTGAGGAAGTTAGTTTTTTGTTTTGATGAAATGCTTTCGTTTTTTAAATCTTAATTCTGCTGTCCACATCCT
CCCAAAGTGTGCTTACTTCATTTGTTTAATTTAAATGAACTTTCCTCCTTGTATGTATGAGGTGACTTGGTGGGTGGGGTGGGTGGTTTT
TGTTTTTGTGTTTTTTCTTTCTTAGGGCATCTGTAGGCCTCAAAGGACCTTTCCTTTAGGTCATATTCCTCAGAAAGTCTTCAATCTTCC
CTTGTTTTTGTTTGTTTGTTTTTCTTAAAGAATATTTTCAAAGCTTAAATTTGTATATTAATTTAGGACTATTTAGAAGTATAGGCTGTC

>71945_71945_2_RALGAPB-RPRD1B_RALGAPB_chr20_37145013_ENST00000397038_RPRD1B_chr20_36694483_ENST00000373433_length(amino acids)=464AA_BP=348
MYFSGTMYSEWRSLHLVIQNDQGHTSVLHSYPESVGREVANAVVRPLGQVLGTPSVAGSENLLKTDKEVKWTMEVICYGLTLPLDGETVK
YCVDVYTDWIMALVLPKDSIPLPVIKEPNQYVQTILKHLQNLFVPRQEQGSSQIRLCLQVLRAIQKLARESSLMARETWEVLLLFLLQIN
DILLAPPTVQGGIAENLAEKLIGVLFEVWLLACTRCFPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTYGPSFPAFKVPD
EDASLIPPEMDNECVAQTWFRFLHMLSNPVDLSNPAIISSTPKFQEQFLNVSGMPQELNQYPCLKHLPQIFFRAMRGISCLVDAFLDKEA
AERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLSLLPNVTGG

--------------------------------------------------------------
>71945_71945_3_RALGAPB-RPRD1B_RALGAPB_chr20_37145013_ENST00000397040_RPRD1B_chr20_36694483_ENST00000373433_length(transcript)=3926nt_BP=1109nt
CTTGGCGCCCTGGGAGAGTCGCTGACGGGTGCCATTTGGATTGTACTTTAGTGGCACGATGTACTCTGAGTGGAGGTCACTGCATTTGGT
GATTCAGAATGATCAAGGCCATACCAGTGTGCTGCACAGCTATCCAGAGAGCGTTGGACGAGAGGTGGCAAATGCTGTAGTCCGTCCTCT
TGGGCAGGTGTTAGGTACCCCTTCAGTGGCTGGTAGTGAGAATTTGTTAAAAACTGACAAAGAAGTAAAATGGACCATGGAAGTAATTTG
CTATGGACTGACCCTTCCATTGGATGGAGAGACTGTAAAATATTGCGTTGATGTATATACAGACTGGATTATGGCTTTAGTGTTGCCAAA
AGATTCTATTCCATTGCCAGTTATTAAAGAGCCTAATCAATATGTTCAAACTATACTAAAACACCTACAGAATCTTTTTGTACCAAGACA
GGAACAGGGTTCCAGTCAGATTCGACTATGCTTACAGGTCCTGAGAGCCATTCAGAAACTGGCCCGTGAGTCATCTCTCATGGCCCGAGA
AACTTGGGAAGTCTTACTGTTGTTTCTTCTGCAGATTAACGACATACTTCTGGCCCCACCAACTGTTCAAGGTGGCATTGCTGAGAATCT
AGCAGAGAAGTTGATTGGTGTTCTCTTTGAGGTGTGGTTACTAGCTTGTACTCGGTGCTTCCCAACACCTCCTTATTGGAAAACAGCCAA
GGAGATGGTGGCTAACTGGAGGCATCACCCAGCAGTGGTGGAGCAGTGGAGCAAGGTCATTTGTGCACTCACTTCCAGATTGCTACGCTT
TACATATGGTCCTTCATTTCCTGCATTTAAAGTTCCCGATGAAGATGCCAGTCTGATCCCTCCAGAAATGGATAATGAGTGTGTTGCACA
GACATGGTTTCGCTTTTTACACATGTTAAGTAATCCTGTGGATTTGAGTAACCCAGCTATTATAAGCTCTACTCCCAAATTTCAGGAACA
GTTCTTGAATGTGAGCGGAATGCCGCAAGAATTGAATCAGTATCCCTGCCTTAAACATCTGCCTCAAATATTTTTTCGTGCCATGCGTGG
AATCAGCTGTCTGGTGGATGCATTCTTAGACAAAGAGGCAGCTGAACGTCTTTCAAAAACAGTAGATGAAGCATGTCTGTTACTAGCAGA
ATATAACGGGCGCCTGGCAGCAGAACTGGAGGACCGTCGCCAGCTGGCTCGGATGTTGGTGGAGTATACCCAGAATCAGAAAGATGTTTT
GTCGGAGAAGGAGAAAAAACTAGAGGAATACAAACAGAAGCTTGCACGAGTAACCCAGGTCCGCAAGGAACTGAAATCCCATATTCAGAG
CTTGCCAGACCTCTCACTGCTGCCCAACGTCACAGGGGGCTTAGCCCCCCTGCCCTCTGCTGGGGACCTGTTTTCAACTGACTAGGATGG
GTGTCATGTCCCAGATTTCTGTTTGTACCAGCAGAAAGAAGAGGGCAAGTCATGGTTGGAAATAACCTTCTAGCCCCTGGTTCTATCCCT
TCTTCCGCCCAGCCCCCCAGCCTCAAGAAAGAACCTCAGACTCTGATTCTCCTCTTCAGCCTCTCATCTTGAGCACAGTTCAGAACAGTG
GCGACTGGAATCTGGTTTATATTCATATTTGCAAAGACTACAGACTTTTTCTCCCACTTCATATTTTCATGCCCCCCTGTTGGTTTTCCA
TTCTTAACTGTCTCCTTATACCTAAGAAGTTATGAAAATCATGTGTACTTCTGGAAGCTTTCGAAAGAATCTTGTCCCTCATGACAGCAT
TTTATCATGAAAGCAGCTTCTCCTTTCTGGGCTGGGCTTGTTCAAGTTCGGTGTGGGCTTCCACTAAGGCACTTGTCCTGGAGACGTTGG
CTTTCCCAGCTGCATCTGCCCCAAAAGGTTGTAGGCACAGCTGTCGTAGCGTTGCCATAAAGAGTTTGCCAAATCTCTGATCCTCCCTTT
CCATTGCTTCTCCTAGTGATGCACGAAGATTAGGTGCATTTATTTTGTAAACAGATTGGAGAATCTAGCAATAAGATTCAAAGCTAATCT
GGAGCATAAAGGCACAGTTCAGAGACAGAATAACAGGGATCACAAGCATGAATTAAAAGGAATTTATTTGCTTCAAGTTCCTAGATACAA
CCTTCCCATGCTGCACTTCTCCACTGTCGGAGCACGTTCCGAAAAACAGAATGCCTTGATCCCTGGTGGGTGCGAAGGCAGTTGTTAGGG
ATGGCAGGCATTGGTGGGCTCCAAAAGATGAAGGCCCCACACACAGGTGTGCTGCATTTGGGATCTGTGTGGGTGTTTCTTGGACCCTTT
CTTCTGGGAGTAGGGTACACACTAACGTTTAATCCGCTGTCTGGGTGCATGTCCACAGTACGGTGGCTAAACTCGAACATCACTGCAAAT
AGGACGCTGAGCAGGTCCGTCTGTCATGTCACGCCACTGCACAGGTCCTTGTCCCCACACGACGGGGAGTACTTGCGTCAGATGTTATTG
AATAGCTCGTCTCGGGCAGGGGAAGCGGGGAGTTGGGGATATTAATTGGGGGTTTTAATTCTATTATCATGTCAGCTGACATTATGACTA
TATAATGTAGTTAGAGACAATTTTTATCTTGCTTATAGTAAAGGTTCAGCCTGCCAATTGTAAATCATTCTAATTTGGCAGGCTTATTTT
TGACATTGGAAAGGGCAGAAAGCGATTTGCCCCAGTAGTGTAATAGGAGTTATAGACCAGAGGCTGAAACCCAAACTATATAAAAAGGAA
TTCAGTGGAGGGGGCTTTGTAATCTCCATTAATTTGTGTTGCTACTTCCAGGATCACCAAAAATTACATGTAATTTTACATGTTAAACAC
ATTGAAACATAACCTATGTTTATAAAGCATAACGGGCTTCCCTTCCAGAAGCTCTCCTGCTTGTCATGAAGTGAGAACAATGAAAAGTCA
TAGCAGATACTCAGTTTAACTCTGTGTAGAACCTAGTAGTGTTTGAGCTGTTATTCAGATTTGAATTCAGACTGTGTGTTGTTTGCTTAT
GGACACTGCCTGTCGTTCTGTCACTGTTAAATTAATGAGTCTATAAGGTTTTTCTTCCAGAGGCCATAGGTGACATCACTAAAATTGCAA
GATAAATTGTAATCTTTGCTGCTGCTGCACTCCCCAACCTCTCCCCCACCCCCCGTGGTGTGCTGCTTTCTAGATGAGCGTGTTTTGGAG
CAGGCCCATCTGGGACACTCTATGCTTTCACCAAGGAAGTGCGATCTGAGCAGCCACAATCCAGCCAAAAGAGGATCGTAGATATTTGCT
CTGATCAACTAGATGAAAATATAGCAGAATGGATTTAGCCCACTGCTCTGTTTTATCCAACTGAGTCTCTGACCAGCAATTGGTGCATAA
TTATTACAGCAAAAGTTAAGAAATGAAACTGTAGCAATTATGTAAATGAATGTGTTGGCCTCTTAATACCTGTTACTAGTGGACTTCCTG
TGAGGAAGTTAGTTTTTTGTTTTGATGAAATGCTTTCGTTTTTTAAATCTTAATTCTGCTGTCCACATCCTCCCAAAGTGTGCTTACTTC
ATTTGTTTAATTTAAATGAACTTTCCTCCTTGTATGTATGAGGTGACTTGGTGGGTGGGGTGGGTGGTTTTTGTTTTTGTGTTTTTTCTT
TCTTAGGGCATCTGTAGGCCTCAAAGGACCTTTCCTTTAGGTCATATTCCTCAGAAAGTCTTCAATCTTCCCTTGTTTTTGTTTGTTTGT
TTTTCTTAAAGAATATTTTCAAAGCTTAAATTTGTATATTAATTTAGGACTATTTAGAAGTATAGGCTGTCGTTGGCGGCAGCAGTATAT

>71945_71945_3_RALGAPB-RPRD1B_RALGAPB_chr20_37145013_ENST00000397040_RPRD1B_chr20_36694483_ENST00000373433_length(amino acids)=464AA_BP=348
MYFSGTMYSEWRSLHLVIQNDQGHTSVLHSYPESVGREVANAVVRPLGQVLGTPSVAGSENLLKTDKEVKWTMEVICYGLTLPLDGETVK
YCVDVYTDWIMALVLPKDSIPLPVIKEPNQYVQTILKHLQNLFVPRQEQGSSQIRLCLQVLRAIQKLARESSLMARETWEVLLLFLLQIN
DILLAPPTVQGGIAENLAEKLIGVLFEVWLLACTRCFPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTYGPSFPAFKVPD
EDASLIPPEMDNECVAQTWFRFLHMLSNPVDLSNPAIISSTPKFQEQFLNVSGMPQELNQYPCLKHLPQIFFRAMRGISCLVDAFLDKEA
AERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLSLLPNVTGG

--------------------------------------------------------------
>71945_71945_4_RALGAPB-RPRD1B_RALGAPB_chr20_37145013_ENST00000397042_RPRD1B_chr20_36694483_ENST00000373433_length(transcript)=4152nt_BP=1335nt
GAGTTATTTGACGCCGCCGCCCCTGGCAGTCGGAAGTTGCCTGAGCAGATCCCAGCCGGCTGGCTCGAGTGGCCTTCGTCGTCCCTTGGC
GCCCTGGGAGAGTCGCTGACGGGTGGACTGACGGACCGCCTGAGGACGGCCGGCCAGGGCGGTGAAAGCGCCAGCCCTATGGCGCGGGTC
GCGTGAGGCGGAAGGCCGAGGACGGCCGGCGGCGGCGCCCGCCCCGGCGATGCGGGCCCCGCCCGTCGCCTCAGGTGCCATTTGGATTGT
ACTTTAGTGGCACGATGTACTCTGAGTGGAGGTCACTGCATTTGGTGATTCAGAATGATCAAGGCCATACCAGTGTGCTGCACAGCTATC
CAGAGAGCGTTGGACGAGAGGTGGCAAATGCTGTAGTCCGTCCTCTTGGGCAGGTGTTAGGTACCCCTTCAGTGGCTGGTAGTGAGAATT
TGTTAAAAACTGACAAAGAAGTAAAATGGACCATGGAAGTAATTTGCTATGGACTGACCCTTCCATTGGATGGAGAGACTGTAAAATATT
GCGTTGATGTATATACAGACTGGATTATGGCTTTAGTGTTGCCAAAAGATTCTATTCCATTGCCAGTTATTAAAGAGCCTAATCAATATG
TTCAAACTATACTAAAACACCTACAGAATCTTTTTGTACCAAGACAGGAACAGGGTTCCAGTCAGATTCGACTATGCTTACAGGTCCTGA
GAGCCATTCAGAAACTGGCCCGTGAGTCATCTCTCATGGCCCGAGAAACTTGGGAAGTCTTACTGTTGTTTCTTCTGCAGATTAACGACA
TACTTCTGGCCCCACCAACTGTTCAAGGTGGCATTGCTGAGAATCTAGCAGAGAAGTTGATTGGTGTTCTCTTTGAGGTGTGGTTACTAG
CTTGTACTCGGTGCTTCCCAACACCTCCTTATTGGAAAACAGCCAAGGAGATGGTGGCTAACTGGAGGCATCACCCAGCAGTGGTGGAGC
AGTGGAGCAAGGTCATTTGTGCACTCACTTCCAGATTGCTACGCTTTACATATGGTCCTTCATTTCCTGCATTTAAAGTTCCCGATGAAG
ATGCCAGTCTGATCCCTCCAGAAATGGATAATGAGTGTGTTGCACAGACATGGTTTCGCTTTTTACACATGTTAAGTAATCCTGTGGATT
TGAGTAACCCAGCTATTATAAGCTCTACTCCCAAATTTCAGGAACAGTTCTTGAATGTGAGCGGAATGCCGCAAGAATTGAATCAGTATC
CCTGCCTTAAACATCTGCCTCAAATATTTTTTCGTGCCATGCGTGGAATCAGCTGTCTGGTGGATGCATTCTTAGACAAAGAGGCAGCTG
AACGTCTTTCAAAAACAGTAGATGAAGCATGTCTGTTACTAGCAGAATATAACGGGCGCCTGGCAGCAGAACTGGAGGACCGTCGCCAGC
TGGCTCGGATGTTGGTGGAGTATACCCAGAATCAGAAAGATGTTTTGTCGGAGAAGGAGAAAAAACTAGAGGAATACAAACAGAAGCTTG
CACGAGTAACCCAGGTCCGCAAGGAACTGAAATCCCATATTCAGAGCTTGCCAGACCTCTCACTGCTGCCCAACGTCACAGGGGGCTTAG
CCCCCCTGCCCTCTGCTGGGGACCTGTTTTCAACTGACTAGGATGGGTGTCATGTCCCAGATTTCTGTTTGTACCAGCAGAAAGAAGAGG
GCAAGTCATGGTTGGAAATAACCTTCTAGCCCCTGGTTCTATCCCTTCTTCCGCCCAGCCCCCCAGCCTCAAGAAAGAACCTCAGACTCT
GATTCTCCTCTTCAGCCTCTCATCTTGAGCACAGTTCAGAACAGTGGCGACTGGAATCTGGTTTATATTCATATTTGCAAAGACTACAGA
CTTTTTCTCCCACTTCATATTTTCATGCCCCCCTGTTGGTTTTCCATTCTTAACTGTCTCCTTATACCTAAGAAGTTATGAAAATCATGT
GTACTTCTGGAAGCTTTCGAAAGAATCTTGTCCCTCATGACAGCATTTTATCATGAAAGCAGCTTCTCCTTTCTGGGCTGGGCTTGTTCA
AGTTCGGTGTGGGCTTCCACTAAGGCACTTGTCCTGGAGACGTTGGCTTTCCCAGCTGCATCTGCCCCAAAAGGTTGTAGGCACAGCTGT
CGTAGCGTTGCCATAAAGAGTTTGCCAAATCTCTGATCCTCCCTTTCCATTGCTTCTCCTAGTGATGCACGAAGATTAGGTGCATTTATT
TTGTAAACAGATTGGAGAATCTAGCAATAAGATTCAAAGCTAATCTGGAGCATAAAGGCACAGTTCAGAGACAGAATAACAGGGATCACA
AGCATGAATTAAAAGGAATTTATTTGCTTCAAGTTCCTAGATACAACCTTCCCATGCTGCACTTCTCCACTGTCGGAGCACGTTCCGAAA
AACAGAATGCCTTGATCCCTGGTGGGTGCGAAGGCAGTTGTTAGGGATGGCAGGCATTGGTGGGCTCCAAAAGATGAAGGCCCCACACAC
AGGTGTGCTGCATTTGGGATCTGTGTGGGTGTTTCTTGGACCCTTTCTTCTGGGAGTAGGGTACACACTAACGTTTAATCCGCTGTCTGG
GTGCATGTCCACAGTACGGTGGCTAAACTCGAACATCACTGCAAATAGGACGCTGAGCAGGTCCGTCTGTCATGTCACGCCACTGCACAG
GTCCTTGTCCCCACACGACGGGGAGTACTTGCGTCAGATGTTATTGAATAGCTCGTCTCGGGCAGGGGAAGCGGGGAGTTGGGGATATTA
ATTGGGGGTTTTAATTCTATTATCATGTCAGCTGACATTATGACTATATAATGTAGTTAGAGACAATTTTTATCTTGCTTATAGTAAAGG
TTCAGCCTGCCAATTGTAAATCATTCTAATTTGGCAGGCTTATTTTTGACATTGGAAAGGGCAGAAAGCGATTTGCCCCAGTAGTGTAAT
AGGAGTTATAGACCAGAGGCTGAAACCCAAACTATATAAAAAGGAATTCAGTGGAGGGGGCTTTGTAATCTCCATTAATTTGTGTTGCTA
CTTCCAGGATCACCAAAAATTACATGTAATTTTACATGTTAAACACATTGAAACATAACCTATGTTTATAAAGCATAACGGGCTTCCCTT
CCAGAAGCTCTCCTGCTTGTCATGAAGTGAGAACAATGAAAAGTCATAGCAGATACTCAGTTTAACTCTGTGTAGAACCTAGTAGTGTTT
GAGCTGTTATTCAGATTTGAATTCAGACTGTGTGTTGTTTGCTTATGGACACTGCCTGTCGTTCTGTCACTGTTAAATTAATGAGTCTAT
AAGGTTTTTCTTCCAGAGGCCATAGGTGACATCACTAAAATTGCAAGATAAATTGTAATCTTTGCTGCTGCTGCACTCCCCAACCTCTCC
CCCACCCCCCGTGGTGTGCTGCTTTCTAGATGAGCGTGTTTTGGAGCAGGCCCATCTGGGACACTCTATGCTTTCACCAAGGAAGTGCGA
TCTGAGCAGCCACAATCCAGCCAAAAGAGGATCGTAGATATTTGCTCTGATCAACTAGATGAAAATATAGCAGAATGGATTTAGCCCACT
GCTCTGTTTTATCCAACTGAGTCTCTGACCAGCAATTGGTGCATAATTATTACAGCAAAAGTTAAGAAATGAAACTGTAGCAATTATGTA
AATGAATGTGTTGGCCTCTTAATACCTGTTACTAGTGGACTTCCTGTGAGGAAGTTAGTTTTTTGTTTTGATGAAATGCTTTCGTTTTTT
AAATCTTAATTCTGCTGTCCACATCCTCCCAAAGTGTGCTTACTTCATTTGTTTAATTTAAATGAACTTTCCTCCTTGTATGTATGAGGT
GACTTGGTGGGTGGGGTGGGTGGTTTTTGTTTTTGTGTTTTTTCTTTCTTAGGGCATCTGTAGGCCTCAAAGGACCTTTCCTTTAGGTCA
TATTCCTCAGAAAGTCTTCAATCTTCCCTTGTTTTTGTTTGTTTGTTTTTCTTAAAGAATATTTTCAAAGCTTAAATTTGTATATTAATT
TAGGACTATTTAGAAGTATAGGCTGTCGTTGGCGGCAGCAGTATATTCTGAAATGTCTCATAGATATATATTTTTGAATAAAGATGGTGT

>71945_71945_4_RALGAPB-RPRD1B_RALGAPB_chr20_37145013_ENST00000397042_RPRD1B_chr20_36694483_ENST00000373433_length(amino acids)=464AA_BP=348
MYFSGTMYSEWRSLHLVIQNDQGHTSVLHSYPESVGREVANAVVRPLGQVLGTPSVAGSENLLKTDKEVKWTMEVICYGLTLPLDGETVK
YCVDVYTDWIMALVLPKDSIPLPVIKEPNQYVQTILKHLQNLFVPRQEQGSSQIRLCLQVLRAIQKLARESSLMARETWEVLLLFLLQIN
DILLAPPTVQGGIAENLAEKLIGVLFEVWLLACTRCFPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTYGPSFPAFKVPD
EDASLIPPEMDNECVAQTWFRFLHMLSNPVDLSNPAIISSTPKFQEQFLNVSGMPQELNQYPCLKHLPQIFFRAMRGISCLVDAFLDKEA
AERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLSLLPNVTGG

--------------------------------------------------------------
>71945_71945_5_RALGAPB-RPRD1B_RALGAPB_chr20_37145013_ENST00000537204_RPRD1B_chr20_36694483_ENST00000373433_length(transcript)=4118nt_BP=1301nt
AGTTGCCTGAGCAGATCCCAGCCGGCTGGCTCGAGTGGCCTTCGTCGTCCCTTGGCGCCCTGGGAGAGTCGCTGACGGGTGGACTGACGG
ACCGCCTGAGGACGGCCGGCCAGGGCGGTGAAAGCGCCAGCCCTATGGCGCGGGTCGCGTGAGGCGGAAGGCCGAGGACGGCCGGCGGCG
GCGCCCGCCCCGGCGATGCGGGCCCCGCCCGTCGCCTCAGGTGCCATTTGGATTGTACTTTAGTGGCACGATGTACTCTGAGTGGAGGTC
ACTGCATTTGGTGATTCAGAATGATCAAGGCCATACCAGTGTGCTGCACAGCTATCCAGAGAGCGTTGGACGAGAGGTGGCAAATGCTGT
AGTCCGTCCTCTTGGGCAGGTGTTAGGTACCCCTTCAGTGGCTGGTAGTGAGAATTTGTTAAAAACTGACAAAGAAGTAAAATGGACCAT
GGAAGTAATTTGCTATGGACTGACCCTTCCATTGGATGGAGAGACTGTAAAATATTGCGTTGATGTATATACAGACTGGATTATGGCTTT
AGTGTTGCCAAAAGATTCTATTCCATTGCCAGTTATTAAAGAGCCTAATCAATATGTTCAAACTATACTAAAACACCTACAGAATCTTTT
TGTACCAAGACAGGAACAGGGTTCCAGTCAGATTCGACTATGCTTACAGGTCCTGAGAGCCATTCAGAAACTGGCCCGTGAGTCATCTCT
CATGGCCCGAGAAACTTGGGAAGTCTTACTGTTGTTTCTTCTGCAGATTAACGACATACTTCTGGCCCCACCAACTGTTCAAGGTGGCAT
TGCTGAGAATCTAGCAGAGAAGTTGATTGGTGTTCTCTTTGAGGTGTGGTTACTAGCTTGTACTCGGTGCTTCCCAACACCTCCTTATTG
GAAAACAGCCAAGGAGATGGTGGCTAACTGGAGGCATCACCCAGCAGTGGTGGAGCAGTGGAGCAAGGTCATTTGTGCACTCACTTCCAG
ATTGCTACGCTTTACATATGGTCCTTCATTTCCTGCATTTAAAGTTCCCGATGAAGATGCCAGTCTGATCCCTCCAGAAATGGATAATGA
GTGTGTTGCACAGACATGGTTTCGCTTTTTACACATGTTAAGTAATCCTGTGGATTTGAGTAACCCAGCTATTATAAGCTCTACTCCCAA
ATTTCAGGAACAGTTCTTGAATGTGAGCGGAATGCCGCAAGAATTGAATCAGTATCCCTGCCTTAAACATCTGCCTCAAATATTTTTTCG
TGCCATGCGTGGAATCAGCTGTCTGGTGGATGCATTCTTAGACAAAGAGGCAGCTGAACGTCTTTCAAAAACAGTAGATGAAGCATGTCT
GTTACTAGCAGAATATAACGGGCGCCTGGCAGCAGAACTGGAGGACCGTCGCCAGCTGGCTCGGATGTTGGTGGAGTATACCCAGAATCA
GAAAGATGTTTTGTCGGAGAAGGAGAAAAAACTAGAGGAATACAAACAGAAGCTTGCACGAGTAACCCAGGTCCGCAAGGAACTGAAATC
CCATATTCAGAGCTTGCCAGACCTCTCACTGCTGCCCAACGTCACAGGGGGCTTAGCCCCCCTGCCCTCTGCTGGGGACCTGTTTTCAAC
TGACTAGGATGGGTGTCATGTCCCAGATTTCTGTTTGTACCAGCAGAAAGAAGAGGGCAAGTCATGGTTGGAAATAACCTTCTAGCCCCT
GGTTCTATCCCTTCTTCCGCCCAGCCCCCCAGCCTCAAGAAAGAACCTCAGACTCTGATTCTCCTCTTCAGCCTCTCATCTTGAGCACAG
TTCAGAACAGTGGCGACTGGAATCTGGTTTATATTCATATTTGCAAAGACTACAGACTTTTTCTCCCACTTCATATTTTCATGCCCCCCT
GTTGGTTTTCCATTCTTAACTGTCTCCTTATACCTAAGAAGTTATGAAAATCATGTGTACTTCTGGAAGCTTTCGAAAGAATCTTGTCCC
TCATGACAGCATTTTATCATGAAAGCAGCTTCTCCTTTCTGGGCTGGGCTTGTTCAAGTTCGGTGTGGGCTTCCACTAAGGCACTTGTCC
TGGAGACGTTGGCTTTCCCAGCTGCATCTGCCCCAAAAGGTTGTAGGCACAGCTGTCGTAGCGTTGCCATAAAGAGTTTGCCAAATCTCT
GATCCTCCCTTTCCATTGCTTCTCCTAGTGATGCACGAAGATTAGGTGCATTTATTTTGTAAACAGATTGGAGAATCTAGCAATAAGATT
CAAAGCTAATCTGGAGCATAAAGGCACAGTTCAGAGACAGAATAACAGGGATCACAAGCATGAATTAAAAGGAATTTATTTGCTTCAAGT
TCCTAGATACAACCTTCCCATGCTGCACTTCTCCACTGTCGGAGCACGTTCCGAAAAACAGAATGCCTTGATCCCTGGTGGGTGCGAAGG
CAGTTGTTAGGGATGGCAGGCATTGGTGGGCTCCAAAAGATGAAGGCCCCACACACAGGTGTGCTGCATTTGGGATCTGTGTGGGTGTTT
CTTGGACCCTTTCTTCTGGGAGTAGGGTACACACTAACGTTTAATCCGCTGTCTGGGTGCATGTCCACAGTACGGTGGCTAAACTCGAAC
ATCACTGCAAATAGGACGCTGAGCAGGTCCGTCTGTCATGTCACGCCACTGCACAGGTCCTTGTCCCCACACGACGGGGAGTACTTGCGT
CAGATGTTATTGAATAGCTCGTCTCGGGCAGGGGAAGCGGGGAGTTGGGGATATTAATTGGGGGTTTTAATTCTATTATCATGTCAGCTG
ACATTATGACTATATAATGTAGTTAGAGACAATTTTTATCTTGCTTATAGTAAAGGTTCAGCCTGCCAATTGTAAATCATTCTAATTTGG
CAGGCTTATTTTTGACATTGGAAAGGGCAGAAAGCGATTTGCCCCAGTAGTGTAATAGGAGTTATAGACCAGAGGCTGAAACCCAAACTA
TATAAAAAGGAATTCAGTGGAGGGGGCTTTGTAATCTCCATTAATTTGTGTTGCTACTTCCAGGATCACCAAAAATTACATGTAATTTTA
CATGTTAAACACATTGAAACATAACCTATGTTTATAAAGCATAACGGGCTTCCCTTCCAGAAGCTCTCCTGCTTGTCATGAAGTGAGAAC
AATGAAAAGTCATAGCAGATACTCAGTTTAACTCTGTGTAGAACCTAGTAGTGTTTGAGCTGTTATTCAGATTTGAATTCAGACTGTGTG
TTGTTTGCTTATGGACACTGCCTGTCGTTCTGTCACTGTTAAATTAATGAGTCTATAAGGTTTTTCTTCCAGAGGCCATAGGTGACATCA
CTAAAATTGCAAGATAAATTGTAATCTTTGCTGCTGCTGCACTCCCCAACCTCTCCCCCACCCCCCGTGGTGTGCTGCTTTCTAGATGAG
CGTGTTTTGGAGCAGGCCCATCTGGGACACTCTATGCTTTCACCAAGGAAGTGCGATCTGAGCAGCCACAATCCAGCCAAAAGAGGATCG
TAGATATTTGCTCTGATCAACTAGATGAAAATATAGCAGAATGGATTTAGCCCACTGCTCTGTTTTATCCAACTGAGTCTCTGACCAGCA
ATTGGTGCATAATTATTACAGCAAAAGTTAAGAAATGAAACTGTAGCAATTATGTAAATGAATGTGTTGGCCTCTTAATACCTGTTACTA
GTGGACTTCCTGTGAGGAAGTTAGTTTTTTGTTTTGATGAAATGCTTTCGTTTTTTAAATCTTAATTCTGCTGTCCACATCCTCCCAAAG
TGTGCTTACTTCATTTGTTTAATTTAAATGAACTTTCCTCCTTGTATGTATGAGGTGACTTGGTGGGTGGGGTGGGTGGTTTTTGTTTTT
GTGTTTTTTCTTTCTTAGGGCATCTGTAGGCCTCAAAGGACCTTTCCTTTAGGTCATATTCCTCAGAAAGTCTTCAATCTTCCCTTGTTT
TTGTTTGTTTGTTTTTCTTAAAGAATATTTTCAAAGCTTAAATTTGTATATTAATTTAGGACTATTTAGAAGTATAGGCTGTCGTTGGCG

>71945_71945_5_RALGAPB-RPRD1B_RALGAPB_chr20_37145013_ENST00000537204_RPRD1B_chr20_36694483_ENST00000373433_length(amino acids)=464AA_BP=348
MYFSGTMYSEWRSLHLVIQNDQGHTSVLHSYPESVGREVANAVVRPLGQVLGTPSVAGSENLLKTDKEVKWTMEVICYGLTLPLDGETVK
YCVDVYTDWIMALVLPKDSIPLPVIKEPNQYVQTILKHLQNLFVPRQEQGSSQIRLCLQVLRAIQKLARESSLMARETWEVLLLFLLQIN
DILLAPPTVQGGIAENLAEKLIGVLFEVWLLACTRCFPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTYGPSFPAFKVPD
EDASLIPPEMDNECVAQTWFRFLHMLSNPVDLSNPAIISSTPKFQEQFLNVSGMPQELNQYPCLKHLPQIFFRAMRGISCLVDAFLDKEA
AERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLSLLPNVTGG

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Fusion Gene PPI Analysis for RALGAPB-RPRD1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RALGAPB-RPRD1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RALGAPB-RPRD1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource