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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RALGAPB-TMC2 (FusionGDB2 ID:71946)

Fusion Gene Summary for RALGAPB-TMC2

check button Fusion gene summary
Fusion gene informationFusion gene name: RALGAPB-TMC2
Fusion gene ID: 71946
HgeneTgene
Gene symbol

RALGAPB

TMC2

Gene ID

57148

117532

Gene nameRal GTPase activating protein non-catalytic subunit betatransmembrane channel like 2
SynonymsKIAA1219|RalGAPbetaC20orf145
Cytomap

20q11.23

20p13

Type of geneprotein-codingprotein-coding
Descriptionral GTPase-activating protein subunit betaRal GTPase activating protein non-catalytic beta subunitRal GTPase activating protein, beta subunit (non-catalytic)transmembrane channel-like protein 2transmembrane cochlear-expressed gene 2transmembrane cochlear-expressed protein 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262879, ENST00000397038, 
ENST00000397040, ENST00000397042, 
ENST00000490114, ENST00000537204, 
ENST00000496948, ENST00000358864, 
Fusion gene scores* DoF score12 X 12 X 9=12964 X 5 X 5=100
# samples 146
** MAII scorelog2(14/1296*10)=-3.21056698593966
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RALGAPB [Title/Abstract] AND TMC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRALGAPB(37191340)-TMC2(2539102), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RALGAPB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-L9-A7SV-01ARALGAPBchr20

37191340

-TMC2chr20

2539102

+


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Fusion Gene ORF analysis for RALGAPB-TMC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262879ENST00000496948RALGAPBchr20

37191340

-TMC2chr20

2539102

+
5CDS-intronENST00000397038ENST00000496948RALGAPBchr20

37191340

-TMC2chr20

2539102

+
5CDS-intronENST00000397040ENST00000496948RALGAPBchr20

37191340

-TMC2chr20

2539102

+
5CDS-intronENST00000397042ENST00000496948RALGAPBchr20

37191340

-TMC2chr20

2539102

+
In-frameENST00000262879ENST00000358864RALGAPBchr20

37191340

-TMC2chr20

2539102

+
In-frameENST00000397038ENST00000358864RALGAPBchr20

37191340

-TMC2chr20

2539102

+
In-frameENST00000397040ENST00000358864RALGAPBchr20

37191340

-TMC2chr20

2539102

+
In-frameENST00000397042ENST00000358864RALGAPBchr20

37191340

-TMC2chr20

2539102

+
intron-3CDSENST00000490114ENST00000358864RALGAPBchr20

37191340

-TMC2chr20

2539102

+
intron-3CDSENST00000537204ENST00000358864RALGAPBchr20

37191340

-TMC2chr20

2539102

+
intron-intronENST00000490114ENST00000496948RALGAPBchr20

37191340

-TMC2chr20

2539102

+
intron-intronENST00000537204ENST00000496948RALGAPBchr20

37191340

-TMC2chr20

2539102

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262879RALGAPBchr2037191340-ENST00000358864TMC2chr202539102+7053398126666192117
ENST00000397042RALGAPBchr2037191340-ENST00000358864TMC2chr202539102+7041396926666072113
ENST00000397038RALGAPBchr2037191340-ENST00000358864TMC2chr202539102+7026395423965922117
ENST00000397040RALGAPBchr2037191340-ENST00000358864TMC2chr202539102+682737554063932117

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262879ENST00000358864RALGAPBchr2037191340-TMC2chr202539102+0.0005762650.99942374
ENST00000397042ENST00000358864RALGAPBchr2037191340-TMC2chr202539102+0.0005909210.9994091
ENST00000397038ENST00000358864RALGAPBchr2037191340-TMC2chr202539102+0.0005445110.9994555
ENST00000397040ENST00000358864RALGAPBchr2037191340-TMC2chr202539102+0.0003965630.99960345

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Fusion Genomic Features for RALGAPB-TMC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RALGAPB-TMC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:37191340/chr20:2539102)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMC2chr20:37191340chr20:2539102ENST00000358864120285_33627907.0Topological domainExtracellular
TgeneTMC2chr20:37191340chr20:2539102ENST00000358864120358_43127907.0Topological domainCytoplasmic
TgeneTMC2chr20:37191340chr20:2539102ENST00000358864120453_50827907.0Topological domainExtracellular
TgeneTMC2chr20:37191340chr20:2539102ENST00000358864120530_69327907.0Topological domainCytoplasmic
TgeneTMC2chr20:37191340chr20:2539102ENST00000358864120715_75027907.0Topological domainExtracellular
TgeneTMC2chr20:37191340chr20:2539102ENST00000358864120772_90627907.0Topological domainCytoplasmic
TgeneTMC2chr20:37191340chr20:2539102ENST00000358864120264_28427907.0TransmembraneHelical
TgeneTMC2chr20:37191340chr20:2539102ENST00000358864120337_35727907.0TransmembraneHelical
TgeneTMC2chr20:37191340chr20:2539102ENST00000358864120432_45227907.0TransmembraneHelical
TgeneTMC2chr20:37191340chr20:2539102ENST00000358864120509_52927907.0TransmembraneHelical
TgeneTMC2chr20:37191340chr20:2539102ENST00000358864120694_71427907.0TransmembraneHelical
TgeneTMC2chr20:37191340chr20:2539102ENST00000358864120751_77127907.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRALGAPBchr20:37191340chr20:2539102ENST00000262879-24301149_139212321495.0DomainRap-GAP
HgeneRALGAPBchr20:37191340chr20:2539102ENST00000397038-24301149_139210101274.0DomainRap-GAP
HgeneRALGAPBchr20:37191340chr20:2539102ENST00000397040-24301149_139212321495.0DomainRap-GAP
TgeneTMC2chr20:37191340chr20:2539102ENST000003588641206_24227907.0Compositional biasNote=Arg/Asp/Glu/Lys-rich (highly charged)
TgeneTMC2chr20:37191340chr20:2539102ENST000003588641201_26327907.0Topological domainCytoplasmic


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Fusion Gene Sequence for RALGAPB-TMC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71946_71946_1_RALGAPB-TMC2_RALGAPB_chr20_37191340_ENST00000262879_TMC2_chr20_2539102_ENST00000358864_length(transcript)=7053nt_BP=3981nt
GAGTTATTTGACGCCGCCGCCCCTGGCAGTCGGAAGTTGCCTGAGCAGATCCCAGCCGGCTGGCTCGAGTGGCCTTCGTCGTCCCTTGGC
GCCCTGGGAGAGTCGCTGACGGGTGGACTGACGGACCGCCTGAGGACGGCCGGCCAGGGCGGTGAAAGCGCCAGCCCTATGGCGCGGGTC
GCGTGAGGCGGAAGGCCGAGGACGGCCGGCGGCGGCGCCCGCCCCGGCGATGCGGGCCCCGCCCGTCGCCTCAGGTGCCATTTGGATTGT
ACTTTAGTGGCACGATGTACTCTGAGTGGAGGTCACTGCATTTGGTGATTCAGAATGATCAAGGCCATACCAGTGTGCTGCACAGCTATC
CAGAGAGCGTTGGACGAGAGGTGGCAAATGCTGTAGTCCGTCCTCTTGGGCAGGTGTTAGGTACCCCTTCAGTGGCTGGTAGTGAGAATT
TGTTAAAAACTGACAAAGAAGTAAAATGGACCATGGAAGTAATTTGCTATGGACTGACCCTTCCATTGGATGGAGAGACTGTAAAATATT
GCGTTGATGTATATACAGACTGGATTATGGCTTTAGTGTTGCCAAAAGATTCTATTCCATTGCCAGTTATTAAAGAGCCTAATCAATATG
TTCAAACTATACTAAAACACCTACAGAATCTTTTTGTACCAAGACAGGAACAGGGTTCCAGTCAGATTCGACTATGCTTACAGGTCCTGA
GAGCCATTCAGAAACTGGCCCGTGAGTCATCTCTCATGGCCCGAGAAACTTGGGAAGTCTTACTGTTGTTTCTTCTGCAGATTAACGACA
TACTTCTGGCCCCACCAACTGTTCAAGGTGGCATTGCTGAGAATCTAGCAGAGAAGTTGATTGGTGTTCTCTTTGAGGTGTGGTTACTAG
CTTGTACTCGGTGCTTCCCAACACCTCCTTATTGGAAAACAGCCAAGGAGATGGTGGCTAACTGGAGGCATCACCCAGCAGTGGTGGAGC
AGTGGAGCAAGGTCATTTGTGCACTCACTTCCAGATTGCTACGCTTTACATATGGTCCTTCATTTCCTGCATTTAAAGTTCCCGATGAAG
ATGCCAGTCTGATCCCTCCAGAAATGGATAATGAGTGTGTTGCACAGACATGGTTTCGCTTTTTACACATGTTAAGTAATCCTGTGGATT
TGAGTAACCCAGCTATTATAAGCTCTACTCCCAAATTTCAGGAACAGTTCTTGAATGTGAGCGGAATGCCGCAAGAATTGAATCAGTATC
CCTGCCTTAAACATCTGCCTCAAATATTTTTTCGTGCCATGCGTGGAATCAGCTGTCTGGTGGATGCATTCTTAGGTATTTCTAGACCCC
GATCAGACAGTGCTCCCCCAACACCCGTGAATAGATTAAGTATGCCTCAAAGTGCTGCTGTCAGTACCACCCCCCCACATAACCGGAGGC
ACCGGGCTGTTACTGTGAATAAGGCCACCATGAAGACAAGCACAGTTAGTACTGCTCATGCCTCTAAAGTTCAGCACCAGACGTCCTCCA
CCTCTCCTCTGTCAAGTCCAAATCAGACTAGTTCAGAACCCCGGCCACTGCCTGCCCCTCGGAGACCAAAGGTTAACAGCATCTTGAATC
TCTTTGGATCATGGTTATTTGATGCAGCATTTGTTCACTGTAAACTTCATAATGGGATAAACAGAGACAGCAGCATGACTGCCATTACAA
CACAAGCTAGCATGGAGTTTCGACGGAAAGGGTCACAAATGTCCACAGACACCATGGTTTCCAATCCTATGTTTGATGCAAGTGAATTTC
CTGATAACTATGAAGCAGGAAGAGCTGAGGCTTGTGGGACACTGTGTAGGATTTTTTGTAGCAAGAAGACTGGAGAAGAGATTCTGCCAG
CTTATTTATCCAGATTTTACATGCTTTTAATTCAAGGTTTGCAGATAAATGATTATGTGTGCCATCCTGTCTTGGCCAGCGTTATTCTAA
ACTCTCCTCCTTTGTTCTGCTGTGACTTGAAAGGGATTGATGTTGTGGTTCCTTACTTTATTTCAGCTCTTGAAACCATTTTGCCTGACA
GAGAACTCTCAAAATTCAAAAGCTATGTAAATCCAACAGAATTGCGAAGATCCTCCATTAATATCCTGCTTTCTTTGTTGCCCCTCCCTC
ATCATTTTGGCACAGTCAAATCTGAGGTGGTCCTGGAAGGAAAGTTTAGTAACGATGACAGCTCTTCTTATGATAAACCAATAACTTTTC
TGTCCCTGAAGTTGAGACTTGTGAATATATTAATAGGTGCCTTGCAAACTGAAACGGACCCCAACAACACCCAAATGATATTAGGGGCAA
TGTTAAATATTGTTCAAGATTCAGCACTTTTGGAAGCCATTGGTTGCCAGATGGAGATGGGTGGTGGAGAAAATAACCTGAAGAGTCATA
GTCGCACCAATAGTGGTATTAGTTCAGCAAGTGGTGGAAGCACGGAGCCCACGACTCCCGATAGTGAGAGACCTGCTCAAGCTCTCTTAA
GAGATTATGCTCTTAATACAGATTCAGCTGCTGGGCTCCTGATTCGCAGCATTCATCTCGTCACCCAAAGACTCAACTCCCAGTGGCGCC
AAGACATGAGCATATCACTGGCAGCTCTAGAGCTCCTCTCTGGCCTTGCAAAGGTAAAAGTGATGGTTGACTCAGGAGACCGGAAGCGAG
CCATCAGTTCTGTGTGCACCTACATTGTTTATCAGTGTAGTCGGCCAGCTCCTTTACACTCCAGGGATCTGCACTCCATGATAGTGGCAG
CTTTTCAGTGTCTCTGTGTCTGGCTGACAGAGCACCCTGATATGCTTGATGAAAAGGACTGCCTTAAGGAAGTACTGGAGATTGTGGAAC
TGGGTATCTCAGGAAGTAAGTCCAAGAACAATGAGCAAGAGGTCAAGTACAAAGGAGATAAGGAGCCAAACCCTGCATCTATGAGGGTAA
AGGATGCTGCTGAAGCCACCCTAACATGCATTATGCAGTTGCTCGGCGCATTTCCTTCACCTAGTGGTCCTGCCTCTCCTTGTAGTCTTG
TGAATGAGACCACTTTGATTAAATACTCCAGGCTGCCAACCATAAACAAGCATAGTTTCCGGTACTTTGTCTTGGATAACAGTGTCATCC
TGGCAATGCTGGAACAACCTCTTGGAAATGAGCAGAATGATTTTTTCCCCTCTGTCACTGTGCTGGTCCGGGGAATGTCTGGAAGACTTG
CTTGGGCACAACAGCTTTGTCTTTTACCCAGAGGAGCAAAAGCAAATCAGAAGCTTTTTGTACCTGAACCTCGCCCAGTTCCTAAAAATG
ACGTTGGATTTAAATATTCTGTGAAACATCGGCCATTTCCTGAAGAGGTGGACAAGATTCCTTTTGTGAAAGCAGATCTCAGCATTCCAG
ATTTGCATGAAATAGTCACTGAAGAATTAGAAGAGAGACACGAAAAATTAAGGAGTGGCATGGCCCAGCAGATTGCTTATGAAATACACC
TTGAGCAACAGAGTGAGGAGGAATTGCAGAAGAGAAGTTTTCCTGACCCAGTTACGGATTGCAAGCCCCCGCCTCCTGCCCAGGAATTCC
AAACAGCCCGCCTTTTTCTCTCACACTTTGGATTTTTGTCCTTAGAAGCACTGAAGGAACCTGCAAATAGTCGTCTACCTCCTCACCTTA
TTGCACTTGATTCCACGATACCTGGATTTTTTGATGACATTGGGTATCTGGATCTCTTGCCATGTCGTCCTTTTGACACAGTTTTTATTT
TCTATATGAAGCCAGGTCAGAAAACGAACCAAGAGATTTTAAAGAATGTGGAGTCTTCCAGAACTGTTCAGCCACATTTCCTAGAATTTT
TGCTTTCCCTTGGCTGGTCAGTAGATGTGGGCAGACACCCTGGTTGGACTGGGCATGTTTCTACCAGTTGGTCTATTAATTGTTGTGATG
ATGGTGAAGGATCTCAACAAGGTGACAGGCTGGGAAGGAGATCCTCAAGCAAGCGGGCTCTCAAAGCCGAGGGGACCCCAGGCAGGCGCG
GAGCTCAGCGAAGCCAGAAGGAGCGCGCCGGGGGCAGCCCAAGCCCGGGGTCTCCCCGGAGGAAGCAAACAGGGCGCAGGAGACACAGAG
AAGAGCTGGGGGAGCAGGAGCGGGGCGAGGCAGAGAGGACCTGCGAGGGCAGGAGAAAGCGCGACGAGAGGGCCTCCTTCCAGGAGCGGA
CAGCAGCCCCAAAGAGGGAAAAGGAGATTCCGAGGAGGGAGGAGAAGTCGAAGCGGCAGAAGAAACCCAGGTCATCCTCCTTGGCCTCCA
GTGCCTCTGGTGGGGAGTCCCTGTCCGAGGAGGAACTGGCCCAGATCCTGGAGCAGGTGGAAGAAAAAAAGAAGCTCATTGCCACCATGC
GGAGCAAGCCCTGGCCCATGGCGAAGAAGCTGACAGAGCTCAGGGAGGCCCAGGAATTTGTGGAGAAGTATGAAGGTGCCTTGGGAAAGG
GGAAAGGCAAGCAACTATATGCCTACAAGATGCTGATGGCCAAGAAATGGGTCAAATTTAAGAGAGACTTTGATAATTTCAAGACTCAAT
GTATCCCCTGGGAAATGAAGATCAAGGACATTGAAAGTCACTTTGGTTCTTCAGTGGCATCGTATTTCATCTTTCTCCGATGGATGTATG
GAGTTAACCTTGTCCTTTTTGGCTTAATATTTGGTCTAGTCATAATCCCAGAGGTACTGATGGGCATGCCCTATGGGAGTATTCCCAGAA
AGACAGTGCCTCGGGCTGAGGAAGAAAAGGCCATGGATTTTTCTGTCCTTTGGGATTTTGAGGGCTATATCAAGTACTCTGCACTCTTCT
ATGGCTACTACAACAACCAGAGGACCATCGGGTGGCTGAGGTACCGGCTGCCTATGGCTTACTTTATGGTGGGGGTCAGCGTGTTCGGCT
ACAGCCTGATTATTGTCATTCGATCGATGGCCAGCAATACCCAAGGAAGCACAGGCGAAGGGGAGAGTGACAACTTCACATTCAGCTTCA
AGATGTTCACCAGCTGGGACTACCTGATCGGGAATTCAGAGACAGCTGATAACAAATATGCATCCATCACCACCAGCTTCAAGGAATCAA
TAGTGGATGAACAAGAGAGTAACAAAGAAGAAAATATCCATCTGACAAGATTTCTTCGTGTCCTGGCCAACTTTCTCATCATCTGCTGTT
TGTGTGGAAGTGGGTACCTCATTTACTTTGTGGTTAAGCGATCTCAGCAATTCTCCAAAATGCAGAATGTCAGCTGGTATGAAAGGAATG
AGGTAGAGATCGTGATGTCCCTGCTTGGAATGTTTTGTCCCCCTCTGTTTGAAACCATCGCTGCCCTGGAGAATTACCACCCACGCACTG
GACTGAAGTGGCAGCTGGGACGCATCTTTGCACTCTTCCTGGGGAACCTCTACACATTTCTCTTGGCCCTGATGGATGACGTCCACCTCA
AGCTTGCTAATGAAGAGACAATAAAGAACATCACTCACTGGACTCTGTTTAACTATTACAACTCTTCTGGTTGGAACGAGAGTGTCCCCC
GACCACCCCTGCACCCTGCAGATGTGCCCCGGGGTTCTTGCTGGGAGACAGCTGTGGGCATTGAATTCATGAGGCTGACGGTGTCTGACA
TGCTGGTAACGTACATCACCATCCTGCTGGGGGACTTCCTACGGGCTTGTTTTGTGCGGTTCATGAACTACTGCTGGTGCTGGGACTTGG
AGGCTGGATTTCCTTCATATGCTGAGTTTGATATTAGTGGAAATGTGCTGGGTTTGATCTTCAACCAAGGAATGATCTGGATGGGCTCCT
TCTATGCTCCAGGCCTGGTGGGCATTAATGTGCTGCGCCTGCTGACCTCCATGTACTTCCAGTGCTGGGCGGTGATGAGCAGCAACGTAC
CCCATGAACGCGTGTTCAAAGCCTCCCGATCCAACAACTTCTACATGGGCCTCCTGCTGCTGGTGCTCTTCCTCAGCCTCCTGCCGGTGG
CCTACACCATCATGTCCCTCCCACCCTCCTTTGACTGCGGGCCGTTCAGTGGGAAAAACAGAATGTACGATGTCCTCCAAGAGACCATTG
AAAACGATTTCCCAACCTTCCTGGGCAAGATCTTTGCTTTCCTCGCCAATCCAGGCCTGATCATCCCAGCCATCCTGCTGATGTTCTTGG
CCATTTACTACCTGAACTCAGTTTCCAAAAGCCTTTCCCGAGCTAATGCCCAGCTGAGGAAGAAAATCCAAGTGCTCCGTGAAGTTGAGA
AGAGTCACAAATCTGTAAAAGGCAAAGCCACAGCCAGAGATTCAGAGGACACACCTAAAAGCAGCTCCAAAAATGCCACCCAGCTCCAAC
TCACCAAGGAAGAGACCACTCCTCCCTCTGCCAGCCAAAGCCAGGCCATGGACAAGAAGGCGCAGGGCCCTGGGACCTCCAATTCTGCCA
GCAGGACCACACTGCCTGCCTCTGGACACCTTCCTATATCTCGGCCCCCTGGAATCGGACCAGATTCTGGCCACGCCCCATCTCAGACTC
ATCCGTGGAGGTCAGCCTCTGGAAAGAGTGCTCAGAGACCTCCCCACTGATGGCTAGGACTCCAGGGAGCCTCGACCCTAGGGCTGATCC
TCAAGTACCCCAGTTTCACACATACCAAACCAAGGTTCTCTCCCCTCTTTCCTCTCACATACATGCTCTGTCTCCTCTCTTGGAATGCAT
GAACTTTGATTCCTTCAGGCCCTTGTCAGCTACCGAAGGAGGAAGACAGTGGCTTCACCTGTCCTTTAGGGAAGCTGGAGCCATCTCTGC
ACTAACTGCCCTCCCAAATATCTTGGTTCAGACAGCTCTGAACCCCACGCTCACAGTGGTCGACCTTGCCTCCCGATTTTCGGAGTTGGG
GAAGGGCCATGACCACCCTCGTAGACTTTTTCCATGGGATACAGTTTAGGACACGGGTTTCTGCCAGCTTCCCTAACCAGGAGGGGGATG

>71946_71946_1_RALGAPB-TMC2_RALGAPB_chr20_37191340_ENST00000262879_TMC2_chr20_2539102_ENST00000358864_length(amino acids)=2117AA_BP=1238
MYFSGTMYSEWRSLHLVIQNDQGHTSVLHSYPESVGREVANAVVRPLGQVLGTPSVAGSENLLKTDKEVKWTMEVICYGLTLPLDGETVK
YCVDVYTDWIMALVLPKDSIPLPVIKEPNQYVQTILKHLQNLFVPRQEQGSSQIRLCLQVLRAIQKLARESSLMARETWEVLLLFLLQIN
DILLAPPTVQGGIAENLAEKLIGVLFEVWLLACTRCFPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTYGPSFPAFKVPD
EDASLIPPEMDNECVAQTWFRFLHMLSNPVDLSNPAIISSTPKFQEQFLNVSGMPQELNQYPCLKHLPQIFFRAMRGISCLVDAFLGISR
PRSDSAPPTPVNRLSMPQSAAVSTTPPHNRRHRAVTVNKATMKTSTVSTAHASKVQHQTSSTSPLSSPNQTSSEPRPLPAPRRPKVNSIL
NLFGSWLFDAAFVHCKLHNGINRDSSMTAITTQASMEFRRKGSQMSTDTMVSNPMFDASEFPDNYEAGRAEACGTLCRIFCSKKTGEEIL
PAYLSRFYMLLIQGLQINDYVCHPVLASVILNSPPLFCCDLKGIDVVVPYFISALETILPDRELSKFKSYVNPTELRRSSINILLSLLPL
PHHFGTVKSEVVLEGKFSNDDSSSYDKPITFLSLKLRLVNILIGALQTETDPNNTQMILGAMLNIVQDSALLEAIGCQMEMGGGENNLKS
HSRTNSGISSASGGSTEPTTPDSERPAQALLRDYALNTDSAAGLLIRSIHLVTQRLNSQWRQDMSISLAALELLSGLAKVKVMVDSGDRK
RAISSVCTYIVYQCSRPAPLHSRDLHSMIVAAFQCLCVWLTEHPDMLDEKDCLKEVLEIVELGISGSKSKNNEQEVKYKGDKEPNPASMR
VKDAAEATLTCIMQLLGAFPSPSGPASPCSLVNETTLIKYSRLPTINKHSFRYFVLDNSVILAMLEQPLGNEQNDFFPSVTVLVRGMSGR
LAWAQQLCLLPRGAKANQKLFVPEPRPVPKNDVGFKYSVKHRPFPEEVDKIPFVKADLSIPDLHEIVTEELEERHEKLRSGMAQQIAYEI
HLEQQSEEELQKRSFPDPVTDCKPPPPAQEFQTARLFLSHFGFLSLEALKEPANSRLPPHLIALDSTIPGFFDDIGYLDLLPCRPFDTVF
IFYMKPGQKTNQEILKNVESSRTVQPHFLEFLLSLGWSVDVGRHPGWTGHVSTSWSINCCDDGEGSQQGDRLGRRSSSKRALKAEGTPGR
RGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLA
SSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKT
QCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEKAMDFSVLWDFEGYIKYSAL
FYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLIIVIRSMASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNSETADNKYASITTSFKE
SIVDEQESNKEENIHLTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPR
TGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPRPPLHPADVPRGSCWETAVGIEFMRLTVS
DMLVTYITILLGDFLRACFVRFMNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSN
VPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPSFDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLANPGLIIPAILLMF
LAIYYLNSVSKSLSRANAQLRKKIQVLREVEKSHKSVKGKATARDSEDTPKSSSKNATQLQLTKEETTPPSASQSQAMDKKAQGPGTSNS

--------------------------------------------------------------
>71946_71946_2_RALGAPB-TMC2_RALGAPB_chr20_37191340_ENST00000397038_TMC2_chr20_2539102_ENST00000358864_length(transcript)=7026nt_BP=3954nt
AGTCGGAAGTTGCCTGAGCAGATCCCAGCCGGCTGGCTCGAGTGGCCTTCGTCGTCCCTTGGCGCCCTGGGAGAGTCGCTGACGGGTGGA
CTGACGGACCGCCTGAGGACGGCCGGCCAGGGCGGTGAAAGCGCCAGCCCTATGGCGCGGGTCGCGTGAGGCGGAAGGCCGAGGACGGCC
GGCGGCGGCGCCCGCCCCGGCGATGCGGGCCCCGCCCGTCGCCTCAGGTGCCATTTGGATTGTACTTTAGTGGCACGATGTACTCTGAGT
GGAGGTCACTGCATTTGGTGATTCAGAATGATCAAGGCCATACCAGTGTGCTGCACAGCTATCCAGAGAGCGTTGGACGAGAGGTGGCAA
ATGCTGTAGTCCGTCCTCTTGGGCAGGTGTTAGGTACCCCTTCAGTGGCTGGTAGTGAGAATTTGTTAAAAACTGACAAAGAAGTAAAAT
GGACCATGGAAGTAATTTGCTATGGACTGACCCTTCCATTGGATGGAGAGACTGTAAAATATTGCGTTGATGTATATACAGACTGGATTA
TGGCTTTAGTGTTGCCAAAAGATTCTATTCCATTGCCAGTTATTAAAGAGCCTAATCAATATGTTCAAACTATACTAAAACACCTACAGA
ATCTTTTTGTACCAAGACAGGAACAGGGTTCCAGTCAGATTCGACTATGCTTACAGGTCCTGAGAGCCATTCAGAAACTGGCCCGTGAGT
CATCTCTCATGGCCCGAGAAACTTGGGAAGTCTTACTGTTGTTTCTTCTGCAGATTAACGACATACTTCTGGCCCCACCAACTGTTCAAG
GTGGCATTGCTGAGAATCTAGCAGAGAAGTTGATTGGTGTTCTCTTTGAGGTGTGGTTACTAGCTTGTACTCGGTGCTTCCCAACACCTC
CTTATTGGAAAACAGCCAAGGAGATGGTGGCTAACTGGAGGCATCACCCAGCAGTGGTGGAGCAGTGGAGCAAGGTCATTTGTGCACTCA
CTTCCAGATTGCTACGCTTTACATATGGTCCTTCATTTCCTGCATTTAAAGTTCCCGATGAAGATGCCAGTCTGATCCCTCCAGAAATGG
ATAATGAGTGTGTTGCACAGACATGGTTTCGCTTTTTACACATGTTAAGTAATCCTGTGGATTTGAGTAACCCAGCTATTATAAGCTCTA
CTCCCAAATTTCAGGAACAGTTCTTGAATGTGAGCGGAATGCCGCAAGAATTGAATCAGTATCCCTGCCTTAAACATCTGCCTCAAATAT
TTTTTCGTGCCATGCGTGGAATCAGCTGTCTGGTGGATGCATTCTTAGGTATTTCTAGACCCCGATCAGACAGTGCTCCCCCAACACCCG
TGAATAGATTAAGTATGCCTCAAAGTGCTGCTGTCAGTACCACCCCCCCACATAACCGGAGGCACCGGGCTGTTACTGTGAATAAGGCCA
CCATGAAGACAAGCACAGTTAGTACTGCTCATGCCTCTAAAGTTCAGCACCAGACGTCCTCCACCTCTCCTCTGTCAAGTCCAAATCAGA
CTAGTTCAGAACCCCGGCCACTGCCTGCCCCTCGGAGACCAAAGGTTAACAGCATCTTGAATCTCTTTGGATCATGGTTATTTGATGCAG
CATTTGTTCACTGTAAACTTCATAATGGGATAAACAGAGACAGCAGCATGACTGCCATTACAACACAAGCTAGCATGGAGTTTCGACGGA
AAGGGTCACAAATGTCCACAGACACCATGGTTTCCAATCCTATGTTTGATGCAAGTGAATTTCCTGATAACTATGAAGCAGGAAGAGCTG
AGGCTTGTGGGACACTGTGTAGGATTTTTTGTAGCAAGAAGACTGGAGAAGAGATTCTGCCAGCTTATTTATCCAGATTTTACATGCTTT
TAATTCAAGGTTTGCAGATAAATGATTATGTGTGCCATCCTGTCTTGGCCAGCGTTATTCTAAACTCTCCTCCTTTGTTCTGCTGTGACT
TGAAAGGGATTGATGTTGTGGTTCCTTACTTTATTTCAGCTCTTGAAACCATTTTGCCTGACAGAGAACTCTCAAAATTCAAAAGCTATG
TAAATCCAACAGAATTGCGAAGATCCTCCATTAATATCCTGCTTTCTTTGTTGCCCCTCCCTCATCATTTTGGCACAGTCAAATCTGAGG
TGGTCCTGGAAGGAAAGTTTAGTAACGATGACAGCTCTTCTTATGATAAACCAATAACTTTTCTGTCCCTGAAGTTGAGACTTGTGAATA
TATTAATAGGTGCCTTGCAAACTGAAACGGACCCCAACAACACCCAAATGATATTAGGGGCAATGTTAAATATTGTTCAAGATTCAGCAC
TTTTGGAAGCCATTGGTTGCCAGATGGAGATGGGTGGTGGAGAAAATAACCTGAAGAGTCATAGTCGCACCAATAGTGGTATTAGTTCAG
CAAGTGGTGGAAGCACGGAGCCCACGACTCCCGATAGTGAGAGACCTGCTCAAGCTCTCTTAAGAGATTATGCTCTTAATACAGATTCAG
CTGCTGGGCTCCTGATTCGCAGCATTCATCTCGTCACCCAAAGACTCAACTCCCAGTGGCGCCAAGACATGAGCATATCACTGGCAGCTC
TAGAGCTCCTCTCTGGCCTTGCAAAGGTAAAAGTGATGGTTGACTCAGGAGACCGGAAGCGAGCCATCAGTTCTGTGTGCACCTACATTG
TTTATCAGTGTAGTCGGCCAGCTCCTTTACACTCCAGGGATCTGCACTCCATGATAGTGGCAGCTTTTCAGTGTCTCTGTGTCTGGCTGA
CAGAGCACCCTGATATGCTTGATGAAAAGGACTGCCTTAAGGAAGTACTGGAGATTGTGGAACTGGGTATCTCAGGAAGTAAGTCCAAGA
ACAATGAGCAAGAGGTCAAGTACAAAGGAGATAAGGAGCCAAACCCTGCATCTATGAGGGTAAAGGATGCTGCTGAAGCCACCCTAACAT
GCATTATGCAGTTGCTCGGCGCATTTCCTTCACCTAGTGGTCCTGCCTCTCCTTGTAGTCTTGTGAATGAGACCACTTTGATTAAATACT
CCAGGCTGCCAACCATAAACAAGCATAGTTTCCGGTACTTTGTCTTGGATAACAGTGTCATCCTGGCAATGCTGGAACAACCTCTTGGAA
ATGAGCAGAATGATTTTTTCCCCTCTGTCACTGTGCTGGTCCGGGGAATGTCTGGAAGACTTGCTTGGGCACAACAGCTTTGTCTTTTAC
CCAGAGGAGCAAAAGCAAATCAGAAGCTTTTTGTACCTGAACCTCGCCCAGTTCCTAAAAATGACGTTGGATTTAAATATTCTGTGAAAC
ATCGGCCATTTCCTGAAGAGGTGGACAAGATTCCTTTTGTGAAAGCAGATCTCAGCATTCCAGATTTGCATGAAATAGTCACTGAAGAAT
TAGAAGAGAGACACGAAAAATTAAGGAGTGGCATGGCCCAGCAGATTGCTTATGAAATACACCTTGAGCAACAGAGTGAGGAGGAATTGC
AGAAGAGAAGTTTTCCTGACCCAGTTACGGATTGCAAGCCCCCGCCTCCTGCCCAGGAATTCCAAACAGCCCGCCTTTTTCTCTCACACT
TTGGATTTTTGTCCTTAGAAGCACTGAAGGAACCTGCAAATAGTCGTCTACCTCCTCACCTTATTGCACTTGATTCCACGATACCTGGAT
TTTTTGATGACATTGGGTATCTGGATCTCTTGCCATGTCGTCCTTTTGACACAGTTTTTATTTTCTATATGAAGCCAGGTCAGAAAACGA
ACCAAGAGATTTTAAAGAATGTGGAGTCTTCCAGAACTGTTCAGCCACATTTCCTAGAATTTTTGCTTTCCCTTGGCTGGTCAGTAGATG
TGGGCAGACACCCTGGTTGGACTGGGCATGTTTCTACCAGTTGGTCTATTAATTGTTGTGATGATGGTGAAGGATCTCAACAAGGTGACA
GGCTGGGAAGGAGATCCTCAAGCAAGCGGGCTCTCAAAGCCGAGGGGACCCCAGGCAGGCGCGGAGCTCAGCGAAGCCAGAAGGAGCGCG
CCGGGGGCAGCCCAAGCCCGGGGTCTCCCCGGAGGAAGCAAACAGGGCGCAGGAGACACAGAGAAGAGCTGGGGGAGCAGGAGCGGGGCG
AGGCAGAGAGGACCTGCGAGGGCAGGAGAAAGCGCGACGAGAGGGCCTCCTTCCAGGAGCGGACAGCAGCCCCAAAGAGGGAAAAGGAGA
TTCCGAGGAGGGAGGAGAAGTCGAAGCGGCAGAAGAAACCCAGGTCATCCTCCTTGGCCTCCAGTGCCTCTGGTGGGGAGTCCCTGTCCG
AGGAGGAACTGGCCCAGATCCTGGAGCAGGTGGAAGAAAAAAAGAAGCTCATTGCCACCATGCGGAGCAAGCCCTGGCCCATGGCGAAGA
AGCTGACAGAGCTCAGGGAGGCCCAGGAATTTGTGGAGAAGTATGAAGGTGCCTTGGGAAAGGGGAAAGGCAAGCAACTATATGCCTACA
AGATGCTGATGGCCAAGAAATGGGTCAAATTTAAGAGAGACTTTGATAATTTCAAGACTCAATGTATCCCCTGGGAAATGAAGATCAAGG
ACATTGAAAGTCACTTTGGTTCTTCAGTGGCATCGTATTTCATCTTTCTCCGATGGATGTATGGAGTTAACCTTGTCCTTTTTGGCTTAA
TATTTGGTCTAGTCATAATCCCAGAGGTACTGATGGGCATGCCCTATGGGAGTATTCCCAGAAAGACAGTGCCTCGGGCTGAGGAAGAAA
AGGCCATGGATTTTTCTGTCCTTTGGGATTTTGAGGGCTATATCAAGTACTCTGCACTCTTCTATGGCTACTACAACAACCAGAGGACCA
TCGGGTGGCTGAGGTACCGGCTGCCTATGGCTTACTTTATGGTGGGGGTCAGCGTGTTCGGCTACAGCCTGATTATTGTCATTCGATCGA
TGGCCAGCAATACCCAAGGAAGCACAGGCGAAGGGGAGAGTGACAACTTCACATTCAGCTTCAAGATGTTCACCAGCTGGGACTACCTGA
TCGGGAATTCAGAGACAGCTGATAACAAATATGCATCCATCACCACCAGCTTCAAGGAATCAATAGTGGATGAACAAGAGAGTAACAAAG
AAGAAAATATCCATCTGACAAGATTTCTTCGTGTCCTGGCCAACTTTCTCATCATCTGCTGTTTGTGTGGAAGTGGGTACCTCATTTACT
TTGTGGTTAAGCGATCTCAGCAATTCTCCAAAATGCAGAATGTCAGCTGGTATGAAAGGAATGAGGTAGAGATCGTGATGTCCCTGCTTG
GAATGTTTTGTCCCCCTCTGTTTGAAACCATCGCTGCCCTGGAGAATTACCACCCACGCACTGGACTGAAGTGGCAGCTGGGACGCATCT
TTGCACTCTTCCTGGGGAACCTCTACACATTTCTCTTGGCCCTGATGGATGACGTCCACCTCAAGCTTGCTAATGAAGAGACAATAAAGA
ACATCACTCACTGGACTCTGTTTAACTATTACAACTCTTCTGGTTGGAACGAGAGTGTCCCCCGACCACCCCTGCACCCTGCAGATGTGC
CCCGGGGTTCTTGCTGGGAGACAGCTGTGGGCATTGAATTCATGAGGCTGACGGTGTCTGACATGCTGGTAACGTACATCACCATCCTGC
TGGGGGACTTCCTACGGGCTTGTTTTGTGCGGTTCATGAACTACTGCTGGTGCTGGGACTTGGAGGCTGGATTTCCTTCATATGCTGAGT
TTGATATTAGTGGAAATGTGCTGGGTTTGATCTTCAACCAAGGAATGATCTGGATGGGCTCCTTCTATGCTCCAGGCCTGGTGGGCATTA
ATGTGCTGCGCCTGCTGACCTCCATGTACTTCCAGTGCTGGGCGGTGATGAGCAGCAACGTACCCCATGAACGCGTGTTCAAAGCCTCCC
GATCCAACAACTTCTACATGGGCCTCCTGCTGCTGGTGCTCTTCCTCAGCCTCCTGCCGGTGGCCTACACCATCATGTCCCTCCCACCCT
CCTTTGACTGCGGGCCGTTCAGTGGGAAAAACAGAATGTACGATGTCCTCCAAGAGACCATTGAAAACGATTTCCCAACCTTCCTGGGCA
AGATCTTTGCTTTCCTCGCCAATCCAGGCCTGATCATCCCAGCCATCCTGCTGATGTTCTTGGCCATTTACTACCTGAACTCAGTTTCCA
AAAGCCTTTCCCGAGCTAATGCCCAGCTGAGGAAGAAAATCCAAGTGCTCCGTGAAGTTGAGAAGAGTCACAAATCTGTAAAAGGCAAAG
CCACAGCCAGAGATTCAGAGGACACACCTAAAAGCAGCTCCAAAAATGCCACCCAGCTCCAACTCACCAAGGAAGAGACCACTCCTCCCT
CTGCCAGCCAAAGCCAGGCCATGGACAAGAAGGCGCAGGGCCCTGGGACCTCCAATTCTGCCAGCAGGACCACACTGCCTGCCTCTGGAC
ACCTTCCTATATCTCGGCCCCCTGGAATCGGACCAGATTCTGGCCACGCCCCATCTCAGACTCATCCGTGGAGGTCAGCCTCTGGAAAGA
GTGCTCAGAGACCTCCCCACTGATGGCTAGGACTCCAGGGAGCCTCGACCCTAGGGCTGATCCTCAAGTACCCCAGTTTCACACATACCA
AACCAAGGTTCTCTCCCCTCTTTCCTCTCACATACATGCTCTGTCTCCTCTCTTGGAATGCATGAACTTTGATTCCTTCAGGCCCTTGTC
AGCTACCGAAGGAGGAAGACAGTGGCTTCACCTGTCCTTTAGGGAAGCTGGAGCCATCTCTGCACTAACTGCCCTCCCAAATATCTTGGT
TCAGACAGCTCTGAACCCCACGCTCACAGTGGTCGACCTTGCCTCCCGATTTTCGGAGTTGGGGAAGGGCCATGACCACCCTCGTAGACT
TTTTCCATGGGATACAGTTTAGGACACGGGTTTCTGCCAGCTTCCCTAACCAGGAGGGGGATGGAGAAGGGCCTACATTTCTCAATCCAG

>71946_71946_2_RALGAPB-TMC2_RALGAPB_chr20_37191340_ENST00000397038_TMC2_chr20_2539102_ENST00000358864_length(amino acids)=2117AA_BP=1238
MYFSGTMYSEWRSLHLVIQNDQGHTSVLHSYPESVGREVANAVVRPLGQVLGTPSVAGSENLLKTDKEVKWTMEVICYGLTLPLDGETVK
YCVDVYTDWIMALVLPKDSIPLPVIKEPNQYVQTILKHLQNLFVPRQEQGSSQIRLCLQVLRAIQKLARESSLMARETWEVLLLFLLQIN
DILLAPPTVQGGIAENLAEKLIGVLFEVWLLACTRCFPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTYGPSFPAFKVPD
EDASLIPPEMDNECVAQTWFRFLHMLSNPVDLSNPAIISSTPKFQEQFLNVSGMPQELNQYPCLKHLPQIFFRAMRGISCLVDAFLGISR
PRSDSAPPTPVNRLSMPQSAAVSTTPPHNRRHRAVTVNKATMKTSTVSTAHASKVQHQTSSTSPLSSPNQTSSEPRPLPAPRRPKVNSIL
NLFGSWLFDAAFVHCKLHNGINRDSSMTAITTQASMEFRRKGSQMSTDTMVSNPMFDASEFPDNYEAGRAEACGTLCRIFCSKKTGEEIL
PAYLSRFYMLLIQGLQINDYVCHPVLASVILNSPPLFCCDLKGIDVVVPYFISALETILPDRELSKFKSYVNPTELRRSSINILLSLLPL
PHHFGTVKSEVVLEGKFSNDDSSSYDKPITFLSLKLRLVNILIGALQTETDPNNTQMILGAMLNIVQDSALLEAIGCQMEMGGGENNLKS
HSRTNSGISSASGGSTEPTTPDSERPAQALLRDYALNTDSAAGLLIRSIHLVTQRLNSQWRQDMSISLAALELLSGLAKVKVMVDSGDRK
RAISSVCTYIVYQCSRPAPLHSRDLHSMIVAAFQCLCVWLTEHPDMLDEKDCLKEVLEIVELGISGSKSKNNEQEVKYKGDKEPNPASMR
VKDAAEATLTCIMQLLGAFPSPSGPASPCSLVNETTLIKYSRLPTINKHSFRYFVLDNSVILAMLEQPLGNEQNDFFPSVTVLVRGMSGR
LAWAQQLCLLPRGAKANQKLFVPEPRPVPKNDVGFKYSVKHRPFPEEVDKIPFVKADLSIPDLHEIVTEELEERHEKLRSGMAQQIAYEI
HLEQQSEEELQKRSFPDPVTDCKPPPPAQEFQTARLFLSHFGFLSLEALKEPANSRLPPHLIALDSTIPGFFDDIGYLDLLPCRPFDTVF
IFYMKPGQKTNQEILKNVESSRTVQPHFLEFLLSLGWSVDVGRHPGWTGHVSTSWSINCCDDGEGSQQGDRLGRRSSSKRALKAEGTPGR
RGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLA
SSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKT
QCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEKAMDFSVLWDFEGYIKYSAL
FYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLIIVIRSMASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNSETADNKYASITTSFKE
SIVDEQESNKEENIHLTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPR
TGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPRPPLHPADVPRGSCWETAVGIEFMRLTVS
DMLVTYITILLGDFLRACFVRFMNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSN
VPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPSFDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLANPGLIIPAILLMF
LAIYYLNSVSKSLSRANAQLRKKIQVLREVEKSHKSVKGKATARDSEDTPKSSSKNATQLQLTKEETTPPSASQSQAMDKKAQGPGTSNS

--------------------------------------------------------------
>71946_71946_3_RALGAPB-TMC2_RALGAPB_chr20_37191340_ENST00000397040_TMC2_chr20_2539102_ENST00000358864_length(transcript)=6827nt_BP=3755nt
CTTGGCGCCCTGGGAGAGTCGCTGACGGGTGCCATTTGGATTGTACTTTAGTGGCACGATGTACTCTGAGTGGAGGTCACTGCATTTGGT
GATTCAGAATGATCAAGGCCATACCAGTGTGCTGCACAGCTATCCAGAGAGCGTTGGACGAGAGGTGGCAAATGCTGTAGTCCGTCCTCT
TGGGCAGGTGTTAGGTACCCCTTCAGTGGCTGGTAGTGAGAATTTGTTAAAAACTGACAAAGAAGTAAAATGGACCATGGAAGTAATTTG
CTATGGACTGACCCTTCCATTGGATGGAGAGACTGTAAAATATTGCGTTGATGTATATACAGACTGGATTATGGCTTTAGTGTTGCCAAA
AGATTCTATTCCATTGCCAGTTATTAAAGAGCCTAATCAATATGTTCAAACTATACTAAAACACCTACAGAATCTTTTTGTACCAAGACA
GGAACAGGGTTCCAGTCAGATTCGACTATGCTTACAGGTCCTGAGAGCCATTCAGAAACTGGCCCGTGAGTCATCTCTCATGGCCCGAGA
AACTTGGGAAGTCTTACTGTTGTTTCTTCTGCAGATTAACGACATACTTCTGGCCCCACCAACTGTTCAAGGTGGCATTGCTGAGAATCT
AGCAGAGAAGTTGATTGGTGTTCTCTTTGAGGTGTGGTTACTAGCTTGTACTCGGTGCTTCCCAACACCTCCTTATTGGAAAACAGCCAA
GGAGATGGTGGCTAACTGGAGGCATCACCCAGCAGTGGTGGAGCAGTGGAGCAAGGTCATTTGTGCACTCACTTCCAGATTGCTACGCTT
TACATATGGTCCTTCATTTCCTGCATTTAAAGTTCCCGATGAAGATGCCAGTCTGATCCCTCCAGAAATGGATAATGAGTGTGTTGCACA
GACATGGTTTCGCTTTTTACACATGTTAAGTAATCCTGTGGATTTGAGTAACCCAGCTATTATAAGCTCTACTCCCAAATTTCAGGAACA
GTTCTTGAATGTGAGCGGAATGCCGCAAGAATTGAATCAGTATCCCTGCCTTAAACATCTGCCTCAAATATTTTTTCGTGCCATGCGTGG
AATCAGCTGTCTGGTGGATGCATTCTTAGGTATTTCTAGACCCCGATCAGACAGTGCTCCCCCAACACCCGTGAATAGATTAAGTATGCC
TCAAAGTGCTGCTGTCAGTACCACCCCCCCACATAACCGGAGGCACCGGGCTGTTACTGTGAATAAGGCCACCATGAAGACAAGCACAGT
TAGTACTGCTCATGCCTCTAAAGTTCAGCACCAGACGTCCTCCACCTCTCCTCTGTCAAGTCCAAATCAGACTAGTTCAGAACCCCGGCC
ACTGCCTGCCCCTCGGAGACCAAAGGTTAACAGCATCTTGAATCTCTTTGGATCATGGTTATTTGATGCAGCATTTGTTCACTGTAAACT
TCATAATGGGATAAACAGAGACAGCAGCATGACTGCCATTACAACACAAGCTAGCATGGAGTTTCGACGGAAAGGGTCACAAATGTCCAC
AGACACCATGGTTTCCAATCCTATGTTTGATGCAAGTGAATTTCCTGATAACTATGAAGCAGGAAGAGCTGAGGCTTGTGGGACACTGTG
TAGGATTTTTTGTAGCAAGAAGACTGGAGAAGAGATTCTGCCAGCTTATTTATCCAGATTTTACATGCTTTTAATTCAAGGTTTGCAGAT
AAATGATTATGTGTGCCATCCTGTCTTGGCCAGCGTTATTCTAAACTCTCCTCCTTTGTTCTGCTGTGACTTGAAAGGGATTGATGTTGT
GGTTCCTTACTTTATTTCAGCTCTTGAAACCATTTTGCCTGACAGAGAACTCTCAAAATTCAAAAGCTATGTAAATCCAACAGAATTGCG
AAGATCCTCCATTAATATCCTGCTTTCTTTGTTGCCCCTCCCTCATCATTTTGGCACAGTCAAATCTGAGGTGGTCCTGGAAGGAAAGTT
TAGTAACGATGACAGCTCTTCTTATGATAAACCAATAACTTTTCTGTCCCTGAAGTTGAGACTTGTGAATATATTAATAGGTGCCTTGCA
AACTGAAACGGACCCCAACAACACCCAAATGATATTAGGGGCAATGTTAAATATTGTTCAAGATTCAGCACTTTTGGAAGCCATTGGTTG
CCAGATGGAGATGGGTGGTGGAGAAAATAACCTGAAGAGTCATAGTCGCACCAATAGTGGTATTAGTTCAGCAAGTGGTGGAAGCACGGA
GCCCACGACTCCCGATAGTGAGAGACCTGCTCAAGCTCTCTTAAGAGATTATGCTCTTAATACAGATTCAGCTGCTGGGCTCCTGATTCG
CAGCATTCATCTCGTCACCCAAAGACTCAACTCCCAGTGGCGCCAAGACATGAGCATATCACTGGCAGCTCTAGAGCTCCTCTCTGGCCT
TGCAAAGGTAAAAGTGATGGTTGACTCAGGAGACCGGAAGCGAGCCATCAGTTCTGTGTGCACCTACATTGTTTATCAGTGTAGTCGGCC
AGCTCCTTTACACTCCAGGGATCTGCACTCCATGATAGTGGCAGCTTTTCAGTGTCTCTGTGTCTGGCTGACAGAGCACCCTGATATGCT
TGATGAAAAGGACTGCCTTAAGGAAGTACTGGAGATTGTGGAACTGGGTATCTCAGGAAGTAAGTCCAAGAACAATGAGCAAGAGGTCAA
GTACAAAGGAGATAAGGAGCCAAACCCTGCATCTATGAGGGTAAAGGATGCTGCTGAAGCCACCCTAACATGCATTATGCAGTTGCTCGG
CGCATTTCCTTCACCTAGTGGTCCTGCCTCTCCTTGTAGTCTTGTGAATGAGACCACTTTGATTAAATACTCCAGGCTGCCAACCATAAA
CAAGCATAGTTTCCGGTACTTTGTCTTGGATAACAGTGTCATCCTGGCAATGCTGGAACAACCTCTTGGAAATGAGCAGAATGATTTTTT
CCCCTCTGTCACTGTGCTGGTCCGGGGAATGTCTGGAAGACTTGCTTGGGCACAACAGCTTTGTCTTTTACCCAGAGGAGCAAAAGCAAA
TCAGAAGCTTTTTGTACCTGAACCTCGCCCAGTTCCTAAAAATGACGTTGGATTTAAATATTCTGTGAAACATCGGCCATTTCCTGAAGA
GGTGGACAAGATTCCTTTTGTGAAAGCAGATCTCAGCATTCCAGATTTGCATGAAATAGTCACTGAAGAATTAGAAGAGAGACACGAAAA
ATTAAGGAGTGGCATGGCCCAGCAGATTGCTTATGAAATACACCTTGAGCAACAGAGTGAGGAGGAATTGCAGAAGAGAAGTTTTCCTGA
CCCAGTTACGGATTGCAAGCCCCCGCCTCCTGCCCAGGAATTCCAAACAGCCCGCCTTTTTCTCTCACACTTTGGATTTTTGTCCTTAGA
AGCACTGAAGGAACCTGCAAATAGTCGTCTACCTCCTCACCTTATTGCACTTGATTCCACGATACCTGGATTTTTTGATGACATTGGGTA
TCTGGATCTCTTGCCATGTCGTCCTTTTGACACAGTTTTTATTTTCTATATGAAGCCAGGTCAGAAAACGAACCAAGAGATTTTAAAGAA
TGTGGAGTCTTCCAGAACTGTTCAGCCACATTTCCTAGAATTTTTGCTTTCCCTTGGCTGGTCAGTAGATGTGGGCAGACACCCTGGTTG
GACTGGGCATGTTTCTACCAGTTGGTCTATTAATTGTTGTGATGATGGTGAAGGATCTCAACAAGGTGACAGGCTGGGAAGGAGATCCTC
AAGCAAGCGGGCTCTCAAAGCCGAGGGGACCCCAGGCAGGCGCGGAGCTCAGCGAAGCCAGAAGGAGCGCGCCGGGGGCAGCCCAAGCCC
GGGGTCTCCCCGGAGGAAGCAAACAGGGCGCAGGAGACACAGAGAAGAGCTGGGGGAGCAGGAGCGGGGCGAGGCAGAGAGGACCTGCGA
GGGCAGGAGAAAGCGCGACGAGAGGGCCTCCTTCCAGGAGCGGACAGCAGCCCCAAAGAGGGAAAAGGAGATTCCGAGGAGGGAGGAGAA
GTCGAAGCGGCAGAAGAAACCCAGGTCATCCTCCTTGGCCTCCAGTGCCTCTGGTGGGGAGTCCCTGTCCGAGGAGGAACTGGCCCAGAT
CCTGGAGCAGGTGGAAGAAAAAAAGAAGCTCATTGCCACCATGCGGAGCAAGCCCTGGCCCATGGCGAAGAAGCTGACAGAGCTCAGGGA
GGCCCAGGAATTTGTGGAGAAGTATGAAGGTGCCTTGGGAAAGGGGAAAGGCAAGCAACTATATGCCTACAAGATGCTGATGGCCAAGAA
ATGGGTCAAATTTAAGAGAGACTTTGATAATTTCAAGACTCAATGTATCCCCTGGGAAATGAAGATCAAGGACATTGAAAGTCACTTTGG
TTCTTCAGTGGCATCGTATTTCATCTTTCTCCGATGGATGTATGGAGTTAACCTTGTCCTTTTTGGCTTAATATTTGGTCTAGTCATAAT
CCCAGAGGTACTGATGGGCATGCCCTATGGGAGTATTCCCAGAAAGACAGTGCCTCGGGCTGAGGAAGAAAAGGCCATGGATTTTTCTGT
CCTTTGGGATTTTGAGGGCTATATCAAGTACTCTGCACTCTTCTATGGCTACTACAACAACCAGAGGACCATCGGGTGGCTGAGGTACCG
GCTGCCTATGGCTTACTTTATGGTGGGGGTCAGCGTGTTCGGCTACAGCCTGATTATTGTCATTCGATCGATGGCCAGCAATACCCAAGG
AAGCACAGGCGAAGGGGAGAGTGACAACTTCACATTCAGCTTCAAGATGTTCACCAGCTGGGACTACCTGATCGGGAATTCAGAGACAGC
TGATAACAAATATGCATCCATCACCACCAGCTTCAAGGAATCAATAGTGGATGAACAAGAGAGTAACAAAGAAGAAAATATCCATCTGAC
AAGATTTCTTCGTGTCCTGGCCAACTTTCTCATCATCTGCTGTTTGTGTGGAAGTGGGTACCTCATTTACTTTGTGGTTAAGCGATCTCA
GCAATTCTCCAAAATGCAGAATGTCAGCTGGTATGAAAGGAATGAGGTAGAGATCGTGATGTCCCTGCTTGGAATGTTTTGTCCCCCTCT
GTTTGAAACCATCGCTGCCCTGGAGAATTACCACCCACGCACTGGACTGAAGTGGCAGCTGGGACGCATCTTTGCACTCTTCCTGGGGAA
CCTCTACACATTTCTCTTGGCCCTGATGGATGACGTCCACCTCAAGCTTGCTAATGAAGAGACAATAAAGAACATCACTCACTGGACTCT
GTTTAACTATTACAACTCTTCTGGTTGGAACGAGAGTGTCCCCCGACCACCCCTGCACCCTGCAGATGTGCCCCGGGGTTCTTGCTGGGA
GACAGCTGTGGGCATTGAATTCATGAGGCTGACGGTGTCTGACATGCTGGTAACGTACATCACCATCCTGCTGGGGGACTTCCTACGGGC
TTGTTTTGTGCGGTTCATGAACTACTGCTGGTGCTGGGACTTGGAGGCTGGATTTCCTTCATATGCTGAGTTTGATATTAGTGGAAATGT
GCTGGGTTTGATCTTCAACCAAGGAATGATCTGGATGGGCTCCTTCTATGCTCCAGGCCTGGTGGGCATTAATGTGCTGCGCCTGCTGAC
CTCCATGTACTTCCAGTGCTGGGCGGTGATGAGCAGCAACGTACCCCATGAACGCGTGTTCAAAGCCTCCCGATCCAACAACTTCTACAT
GGGCCTCCTGCTGCTGGTGCTCTTCCTCAGCCTCCTGCCGGTGGCCTACACCATCATGTCCCTCCCACCCTCCTTTGACTGCGGGCCGTT
CAGTGGGAAAAACAGAATGTACGATGTCCTCCAAGAGACCATTGAAAACGATTTCCCAACCTTCCTGGGCAAGATCTTTGCTTTCCTCGC
CAATCCAGGCCTGATCATCCCAGCCATCCTGCTGATGTTCTTGGCCATTTACTACCTGAACTCAGTTTCCAAAAGCCTTTCCCGAGCTAA
TGCCCAGCTGAGGAAGAAAATCCAAGTGCTCCGTGAAGTTGAGAAGAGTCACAAATCTGTAAAAGGCAAAGCCACAGCCAGAGATTCAGA
GGACACACCTAAAAGCAGCTCCAAAAATGCCACCCAGCTCCAACTCACCAAGGAAGAGACCACTCCTCCCTCTGCCAGCCAAAGCCAGGC
CATGGACAAGAAGGCGCAGGGCCCTGGGACCTCCAATTCTGCCAGCAGGACCACACTGCCTGCCTCTGGACACCTTCCTATATCTCGGCC
CCCTGGAATCGGACCAGATTCTGGCCACGCCCCATCTCAGACTCATCCGTGGAGGTCAGCCTCTGGAAAGAGTGCTCAGAGACCTCCCCA
CTGATGGCTAGGACTCCAGGGAGCCTCGACCCTAGGGCTGATCCTCAAGTACCCCAGTTTCACACATACCAAACCAAGGTTCTCTCCCCT
CTTTCCTCTCACATACATGCTCTGTCTCCTCTCTTGGAATGCATGAACTTTGATTCCTTCAGGCCCTTGTCAGCTACCGAAGGAGGAAGA
CAGTGGCTTCACCTGTCCTTTAGGGAAGCTGGAGCCATCTCTGCACTAACTGCCCTCCCAAATATCTTGGTTCAGACAGCTCTGAACCCC
ACGCTCACAGTGGTCGACCTTGCCTCCCGATTTTCGGAGTTGGGGAAGGGCCATGACCACCCTCGTAGACTTTTTCCATGGGATACAGTT

>71946_71946_3_RALGAPB-TMC2_RALGAPB_chr20_37191340_ENST00000397040_TMC2_chr20_2539102_ENST00000358864_length(amino acids)=2117AA_BP=1238
MYFSGTMYSEWRSLHLVIQNDQGHTSVLHSYPESVGREVANAVVRPLGQVLGTPSVAGSENLLKTDKEVKWTMEVICYGLTLPLDGETVK
YCVDVYTDWIMALVLPKDSIPLPVIKEPNQYVQTILKHLQNLFVPRQEQGSSQIRLCLQVLRAIQKLARESSLMARETWEVLLLFLLQIN
DILLAPPTVQGGIAENLAEKLIGVLFEVWLLACTRCFPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTYGPSFPAFKVPD
EDASLIPPEMDNECVAQTWFRFLHMLSNPVDLSNPAIISSTPKFQEQFLNVSGMPQELNQYPCLKHLPQIFFRAMRGISCLVDAFLGISR
PRSDSAPPTPVNRLSMPQSAAVSTTPPHNRRHRAVTVNKATMKTSTVSTAHASKVQHQTSSTSPLSSPNQTSSEPRPLPAPRRPKVNSIL
NLFGSWLFDAAFVHCKLHNGINRDSSMTAITTQASMEFRRKGSQMSTDTMVSNPMFDASEFPDNYEAGRAEACGTLCRIFCSKKTGEEIL
PAYLSRFYMLLIQGLQINDYVCHPVLASVILNSPPLFCCDLKGIDVVVPYFISALETILPDRELSKFKSYVNPTELRRSSINILLSLLPL
PHHFGTVKSEVVLEGKFSNDDSSSYDKPITFLSLKLRLVNILIGALQTETDPNNTQMILGAMLNIVQDSALLEAIGCQMEMGGGENNLKS
HSRTNSGISSASGGSTEPTTPDSERPAQALLRDYALNTDSAAGLLIRSIHLVTQRLNSQWRQDMSISLAALELLSGLAKVKVMVDSGDRK
RAISSVCTYIVYQCSRPAPLHSRDLHSMIVAAFQCLCVWLTEHPDMLDEKDCLKEVLEIVELGISGSKSKNNEQEVKYKGDKEPNPASMR
VKDAAEATLTCIMQLLGAFPSPSGPASPCSLVNETTLIKYSRLPTINKHSFRYFVLDNSVILAMLEQPLGNEQNDFFPSVTVLVRGMSGR
LAWAQQLCLLPRGAKANQKLFVPEPRPVPKNDVGFKYSVKHRPFPEEVDKIPFVKADLSIPDLHEIVTEELEERHEKLRSGMAQQIAYEI
HLEQQSEEELQKRSFPDPVTDCKPPPPAQEFQTARLFLSHFGFLSLEALKEPANSRLPPHLIALDSTIPGFFDDIGYLDLLPCRPFDTVF
IFYMKPGQKTNQEILKNVESSRTVQPHFLEFLLSLGWSVDVGRHPGWTGHVSTSWSINCCDDGEGSQQGDRLGRRSSSKRALKAEGTPGR
RGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLA
SSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKT
QCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEKAMDFSVLWDFEGYIKYSAL
FYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLIIVIRSMASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNSETADNKYASITTSFKE
SIVDEQESNKEENIHLTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPR
TGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPRPPLHPADVPRGSCWETAVGIEFMRLTVS
DMLVTYITILLGDFLRACFVRFMNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSN
VPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPSFDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLANPGLIIPAILLMF
LAIYYLNSVSKSLSRANAQLRKKIQVLREVEKSHKSVKGKATARDSEDTPKSSSKNATQLQLTKEETTPPSASQSQAMDKKAQGPGTSNS

--------------------------------------------------------------
>71946_71946_4_RALGAPB-TMC2_RALGAPB_chr20_37191340_ENST00000397042_TMC2_chr20_2539102_ENST00000358864_length(transcript)=7041nt_BP=3969nt
GAGTTATTTGACGCCGCCGCCCCTGGCAGTCGGAAGTTGCCTGAGCAGATCCCAGCCGGCTGGCTCGAGTGGCCTTCGTCGTCCCTTGGC
GCCCTGGGAGAGTCGCTGACGGGTGGACTGACGGACCGCCTGAGGACGGCCGGCCAGGGCGGTGAAAGCGCCAGCCCTATGGCGCGGGTC
GCGTGAGGCGGAAGGCCGAGGACGGCCGGCGGCGGCGCCCGCCCCGGCGATGCGGGCCCCGCCCGTCGCCTCAGGTGCCATTTGGATTGT
ACTTTAGTGGCACGATGTACTCTGAGTGGAGGTCACTGCATTTGGTGATTCAGAATGATCAAGGCCATACCAGTGTGCTGCACAGCTATC
CAGAGAGCGTTGGACGAGAGGTGGCAAATGCTGTAGTCCGTCCTCTTGGGCAGGTGTTAGGTACCCCTTCAGTGGCTGGTAGTGAGAATT
TGTTAAAAACTGACAAAGAAGTAAAATGGACCATGGAAGTAATTTGCTATGGACTGACCCTTCCATTGGATGGAGAGACTGTAAAATATT
GCGTTGATGTATATACAGACTGGATTATGGCTTTAGTGTTGCCAAAAGATTCTATTCCATTGCCAGTTATTAAAGAGCCTAATCAATATG
TTCAAACTATACTAAAACACCTACAGAATCTTTTTGTACCAAGACAGGAACAGGGTTCCAGTCAGATTCGACTATGCTTACAGGTCCTGA
GAGCCATTCAGAAACTGGCCCGTGAGTCATCTCTCATGGCCCGAGAAACTTGGGAAGTCTTACTGTTGTTTCTTCTGCAGATTAACGACA
TACTTCTGGCCCCACCAACTGTTCAAGGTGGCATTGCTGAGAATCTAGCAGAGAAGTTGATTGGTGTTCTCTTTGAGGTGTGGTTACTAG
CTTGTACTCGGTGCTTCCCAACACCTCCTTATTGGAAAACAGCCAAGGAGATGGTGGCTAACTGGAGGCATCACCCAGCAGTGGTGGAGC
AGTGGAGCAAGGTCATTTGTGCACTCACTTCCAGATTGCTACGCTTTACATATGGTCCTTCATTTCCTGCATTTAAAGTTCCCGATGAAG
ATGCCAGTCTGATCCCTCCAGAAATGGATAATGAGTGTGTTGCACAGACATGGTTTCGCTTTTTACACATGTTAAGTAATCCTGTGGATT
TGAGTAACCCAGCTATTATAAGCTCTACTCCCAAATTTCAGGAACAGTTCTTGAATGTGAGCGGAATGCCGCAAGAATTGAATCAGTATC
CCTGCCTTAAACATCTGCCTCAAATATTTTTTCGTGCCATGCGTGGAATCAGCTGTCTGGTGGATGCATTCTTAGGTATTTCTAGACCCC
GATCAGACAGTGCTCCCCCAACACCCGTGAATAGATTAAGTATGCCTCAAAGTGCTGCTGTCAGTACCACCCCCCCACATAACCGGAGGC
ACCGGGCTGTTACTGTGAATAAGGCCACCATGAAGACAAGCACAGTTAGTACTGCTCATGCCTCTAAAGTTCAGCACCAGACGTCCTCCA
CCTCTCCTCTGTCAAGTCCAAATCAGACTAGTTCAGAACCCCGGCCACTGCCTGCCCCTCGGAGACCAAAGGTTAACAGCATCTTGAATC
TCTTTGGATCATGGTTATTTGATGCAGCATTTGTTCACTGTAAACTTCATAATGGGATAAACAGAGACAGCAGCATGACTGCCATTACAA
CACAAGCTAGCATGGAGTTTCGACGGAAAGGGTCACAAATGTCCACAGACACCATGGTTTCCAATCCTATGTTTGATGCAAGTGAATTTC
CTGATAACTATGAAGCAGGAAGAGCTGAGGCTTGTGGGACACTGTGTAGGATTTTTTGTAGCAAGAAGACTGGAGAAGAGATTCTGCCAG
CTTATTTATCCAGATTTTACATGCTTTTAATTCAAGGTTTGCAGATAAATGATTATGTGTGCCATCCTGTCTTGGCCAGCGTTATTCTAA
ACTCTCCTCCTTTGTTCTGCTGTGACTTGAAAGGGATTGATGTTGTGGTTCCTTACTTTATTTCAGCTCTTGAAACCATTTTGCCTGACA
GAGAACTCTCAAAATTCAAAAGCTATGTAAATCCAACAGAATTGCGAAGATCCTCCATTAATATCCTGCTTTCTTTGTTGCCCCTCCCTC
ATCATTTTGGCACAGTCAAATCTGAGGTGGTCCTGGAAGGAAAGTTTAGTAACGATGACAGCTCTTCTTATGATAAACCAATAACTTTTC
TGTCCCTGAAGTTGAGACTTGTGAATATATTAATAGGTGCCTTGCAAACTGAAACGGACCCCAACAACACCCAAATGATATTAGGGGCAA
TGTTAAATATTGTTCAAGATTCAGCACTTTTGGAAGCCATTGGTTGCCAGATGGAGATGGGTGGTGGAGAAAATAACCTGAAGAGTCATA
GTCGCACCAATAGTGGTATTAGTTCAGCAAGTGGTGGAAGCACGGAGCCCACGACTCCCGATAGTGAGAGACCTGCTCAAGCTCTCTTAA
GAGATTATGATTCAGCTGCTGGGCTCCTGATTCGCAGCATTCATCTCGTCACCCAAAGACTCAACTCCCAGTGGCGCCAAGACATGAGCA
TATCACTGGCAGCTCTAGAGCTCCTCTCTGGCCTTGCAAAGGTAAAAGTGATGGTTGACTCAGGAGACCGGAAGCGAGCCATCAGTTCTG
TGTGCACCTACATTGTTTATCAGTGTAGTCGGCCAGCTCCTTTACACTCCAGGGATCTGCACTCCATGATAGTGGCAGCTTTTCAGTGTC
TCTGTGTCTGGCTGACAGAGCACCCTGATATGCTTGATGAAAAGGACTGCCTTAAGGAAGTACTGGAGATTGTGGAACTGGGTATCTCAG
GAAGTAAGTCCAAGAACAATGAGCAAGAGGTCAAGTACAAAGGAGATAAGGAGCCAAACCCTGCATCTATGAGGGTAAAGGATGCTGCTG
AAGCCACCCTAACATGCATTATGCAGTTGCTCGGCGCATTTCCTTCACCTAGTGGTCCTGCCTCTCCTTGTAGTCTTGTGAATGAGACCA
CTTTGATTAAATACTCCAGGCTGCCAACCATAAACAAGCATAGTTTCCGGTACTTTGTCTTGGATAACAGTGTCATCCTGGCAATGCTGG
AACAACCTCTTGGAAATGAGCAGAATGATTTTTTCCCCTCTGTCACTGTGCTGGTCCGGGGAATGTCTGGAAGACTTGCTTGGGCACAAC
AGCTTTGTCTTTTACCCAGAGGAGCAAAAGCAAATCAGAAGCTTTTTGTACCTGAACCTCGCCCAGTTCCTAAAAATGACGTTGGATTTA
AATATTCTGTGAAACATCGGCCATTTCCTGAAGAGGTGGACAAGATTCCTTTTGTGAAAGCAGATCTCAGCATTCCAGATTTGCATGAAA
TAGTCACTGAAGAATTAGAAGAGAGACACGAAAAATTAAGGAGTGGCATGGCCCAGCAGATTGCTTATGAAATACACCTTGAGCAACAGA
GTGAGGAGGAATTGCAGAAGAGAAGTTTTCCTGACCCAGTTACGGATTGCAAGCCCCCGCCTCCTGCCCAGGAATTCCAAACAGCCCGCC
TTTTTCTCTCACACTTTGGATTTTTGTCCTTAGAAGCACTGAAGGAACCTGCAAATAGTCGTCTACCTCCTCACCTTATTGCACTTGATT
CCACGATACCTGGATTTTTTGATGACATTGGGTATCTGGATCTCTTGCCATGTCGTCCTTTTGACACAGTTTTTATTTTCTATATGAAGC
CAGGTCAGAAAACGAACCAAGAGATTTTAAAGAATGTGGAGTCTTCCAGAACTGTTCAGCCACATTTCCTAGAATTTTTGCTTTCCCTTG
GCTGGTCAGTAGATGTGGGCAGACACCCTGGTTGGACTGGGCATGTTTCTACCAGTTGGTCTATTAATTGTTGTGATGATGGTGAAGGAT
CTCAACAAGGTGACAGGCTGGGAAGGAGATCCTCAAGCAAGCGGGCTCTCAAAGCCGAGGGGACCCCAGGCAGGCGCGGAGCTCAGCGAA
GCCAGAAGGAGCGCGCCGGGGGCAGCCCAAGCCCGGGGTCTCCCCGGAGGAAGCAAACAGGGCGCAGGAGACACAGAGAAGAGCTGGGGG
AGCAGGAGCGGGGCGAGGCAGAGAGGACCTGCGAGGGCAGGAGAAAGCGCGACGAGAGGGCCTCCTTCCAGGAGCGGACAGCAGCCCCAA
AGAGGGAAAAGGAGATTCCGAGGAGGGAGGAGAAGTCGAAGCGGCAGAAGAAACCCAGGTCATCCTCCTTGGCCTCCAGTGCCTCTGGTG
GGGAGTCCCTGTCCGAGGAGGAACTGGCCCAGATCCTGGAGCAGGTGGAAGAAAAAAAGAAGCTCATTGCCACCATGCGGAGCAAGCCCT
GGCCCATGGCGAAGAAGCTGACAGAGCTCAGGGAGGCCCAGGAATTTGTGGAGAAGTATGAAGGTGCCTTGGGAAAGGGGAAAGGCAAGC
AACTATATGCCTACAAGATGCTGATGGCCAAGAAATGGGTCAAATTTAAGAGAGACTTTGATAATTTCAAGACTCAATGTATCCCCTGGG
AAATGAAGATCAAGGACATTGAAAGTCACTTTGGTTCTTCAGTGGCATCGTATTTCATCTTTCTCCGATGGATGTATGGAGTTAACCTTG
TCCTTTTTGGCTTAATATTTGGTCTAGTCATAATCCCAGAGGTACTGATGGGCATGCCCTATGGGAGTATTCCCAGAAAGACAGTGCCTC
GGGCTGAGGAAGAAAAGGCCATGGATTTTTCTGTCCTTTGGGATTTTGAGGGCTATATCAAGTACTCTGCACTCTTCTATGGCTACTACA
ACAACCAGAGGACCATCGGGTGGCTGAGGTACCGGCTGCCTATGGCTTACTTTATGGTGGGGGTCAGCGTGTTCGGCTACAGCCTGATTA
TTGTCATTCGATCGATGGCCAGCAATACCCAAGGAAGCACAGGCGAAGGGGAGAGTGACAACTTCACATTCAGCTTCAAGATGTTCACCA
GCTGGGACTACCTGATCGGGAATTCAGAGACAGCTGATAACAAATATGCATCCATCACCACCAGCTTCAAGGAATCAATAGTGGATGAAC
AAGAGAGTAACAAAGAAGAAAATATCCATCTGACAAGATTTCTTCGTGTCCTGGCCAACTTTCTCATCATCTGCTGTTTGTGTGGAAGTG
GGTACCTCATTTACTTTGTGGTTAAGCGATCTCAGCAATTCTCCAAAATGCAGAATGTCAGCTGGTATGAAAGGAATGAGGTAGAGATCG
TGATGTCCCTGCTTGGAATGTTTTGTCCCCCTCTGTTTGAAACCATCGCTGCCCTGGAGAATTACCACCCACGCACTGGACTGAAGTGGC
AGCTGGGACGCATCTTTGCACTCTTCCTGGGGAACCTCTACACATTTCTCTTGGCCCTGATGGATGACGTCCACCTCAAGCTTGCTAATG
AAGAGACAATAAAGAACATCACTCACTGGACTCTGTTTAACTATTACAACTCTTCTGGTTGGAACGAGAGTGTCCCCCGACCACCCCTGC
ACCCTGCAGATGTGCCCCGGGGTTCTTGCTGGGAGACAGCTGTGGGCATTGAATTCATGAGGCTGACGGTGTCTGACATGCTGGTAACGT
ACATCACCATCCTGCTGGGGGACTTCCTACGGGCTTGTTTTGTGCGGTTCATGAACTACTGCTGGTGCTGGGACTTGGAGGCTGGATTTC
CTTCATATGCTGAGTTTGATATTAGTGGAAATGTGCTGGGTTTGATCTTCAACCAAGGAATGATCTGGATGGGCTCCTTCTATGCTCCAG
GCCTGGTGGGCATTAATGTGCTGCGCCTGCTGACCTCCATGTACTTCCAGTGCTGGGCGGTGATGAGCAGCAACGTACCCCATGAACGCG
TGTTCAAAGCCTCCCGATCCAACAACTTCTACATGGGCCTCCTGCTGCTGGTGCTCTTCCTCAGCCTCCTGCCGGTGGCCTACACCATCA
TGTCCCTCCCACCCTCCTTTGACTGCGGGCCGTTCAGTGGGAAAAACAGAATGTACGATGTCCTCCAAGAGACCATTGAAAACGATTTCC
CAACCTTCCTGGGCAAGATCTTTGCTTTCCTCGCCAATCCAGGCCTGATCATCCCAGCCATCCTGCTGATGTTCTTGGCCATTTACTACC
TGAACTCAGTTTCCAAAAGCCTTTCCCGAGCTAATGCCCAGCTGAGGAAGAAAATCCAAGTGCTCCGTGAAGTTGAGAAGAGTCACAAAT
CTGTAAAAGGCAAAGCCACAGCCAGAGATTCAGAGGACACACCTAAAAGCAGCTCCAAAAATGCCACCCAGCTCCAACTCACCAAGGAAG
AGACCACTCCTCCCTCTGCCAGCCAAAGCCAGGCCATGGACAAGAAGGCGCAGGGCCCTGGGACCTCCAATTCTGCCAGCAGGACCACAC
TGCCTGCCTCTGGACACCTTCCTATATCTCGGCCCCCTGGAATCGGACCAGATTCTGGCCACGCCCCATCTCAGACTCATCCGTGGAGGT
CAGCCTCTGGAAAGAGTGCTCAGAGACCTCCCCACTGATGGCTAGGACTCCAGGGAGCCTCGACCCTAGGGCTGATCCTCAAGTACCCCA
GTTTCACACATACCAAACCAAGGTTCTCTCCCCTCTTTCCTCTCACATACATGCTCTGTCTCCTCTCTTGGAATGCATGAACTTTGATTC
CTTCAGGCCCTTGTCAGCTACCGAAGGAGGAAGACAGTGGCTTCACCTGTCCTTTAGGGAAGCTGGAGCCATCTCTGCACTAACTGCCCT
CCCAAATATCTTGGTTCAGACAGCTCTGAACCCCACGCTCACAGTGGTCGACCTTGCCTCCCGATTTTCGGAGTTGGGGAAGGGCCATGA
CCACCCTCGTAGACTTTTTCCATGGGATACAGTTTAGGACACGGGTTTCTGCCAGCTTCCCTAACCAGGAGGGGGATGGAGAAGGGCCTA

>71946_71946_4_RALGAPB-TMC2_RALGAPB_chr20_37191340_ENST00000397042_TMC2_chr20_2539102_ENST00000358864_length(amino acids)=2113AA_BP=1234
MYFSGTMYSEWRSLHLVIQNDQGHTSVLHSYPESVGREVANAVVRPLGQVLGTPSVAGSENLLKTDKEVKWTMEVICYGLTLPLDGETVK
YCVDVYTDWIMALVLPKDSIPLPVIKEPNQYVQTILKHLQNLFVPRQEQGSSQIRLCLQVLRAIQKLARESSLMARETWEVLLLFLLQIN
DILLAPPTVQGGIAENLAEKLIGVLFEVWLLACTRCFPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTYGPSFPAFKVPD
EDASLIPPEMDNECVAQTWFRFLHMLSNPVDLSNPAIISSTPKFQEQFLNVSGMPQELNQYPCLKHLPQIFFRAMRGISCLVDAFLGISR
PRSDSAPPTPVNRLSMPQSAAVSTTPPHNRRHRAVTVNKATMKTSTVSTAHASKVQHQTSSTSPLSSPNQTSSEPRPLPAPRRPKVNSIL
NLFGSWLFDAAFVHCKLHNGINRDSSMTAITTQASMEFRRKGSQMSTDTMVSNPMFDASEFPDNYEAGRAEACGTLCRIFCSKKTGEEIL
PAYLSRFYMLLIQGLQINDYVCHPVLASVILNSPPLFCCDLKGIDVVVPYFISALETILPDRELSKFKSYVNPTELRRSSINILLSLLPL
PHHFGTVKSEVVLEGKFSNDDSSSYDKPITFLSLKLRLVNILIGALQTETDPNNTQMILGAMLNIVQDSALLEAIGCQMEMGGGENNLKS
HSRTNSGISSASGGSTEPTTPDSERPAQALLRDYDSAAGLLIRSIHLVTQRLNSQWRQDMSISLAALELLSGLAKVKVMVDSGDRKRAIS
SVCTYIVYQCSRPAPLHSRDLHSMIVAAFQCLCVWLTEHPDMLDEKDCLKEVLEIVELGISGSKSKNNEQEVKYKGDKEPNPASMRVKDA
AEATLTCIMQLLGAFPSPSGPASPCSLVNETTLIKYSRLPTINKHSFRYFVLDNSVILAMLEQPLGNEQNDFFPSVTVLVRGMSGRLAWA
QQLCLLPRGAKANQKLFVPEPRPVPKNDVGFKYSVKHRPFPEEVDKIPFVKADLSIPDLHEIVTEELEERHEKLRSGMAQQIAYEIHLEQ
QSEEELQKRSFPDPVTDCKPPPPAQEFQTARLFLSHFGFLSLEALKEPANSRLPPHLIALDSTIPGFFDDIGYLDLLPCRPFDTVFIFYM
KPGQKTNQEILKNVESSRTVQPHFLEFLLSLGWSVDVGRHPGWTGHVSTSWSINCCDDGEGSQQGDRLGRRSSSKRALKAEGTPGRRGAQ
RSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASSAS
GGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIP
WEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEKAMDFSVLWDFEGYIKYSALFYGY
YNNQRTIGWLRYRLPMAYFMVGVSVFGYSLIIVIRSMASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNSETADNKYASITTSFKESIVD
EQESNKEENIHLTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPRTGLK
WQLGRIFALFLGNLYTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPRPPLHPADVPRGSCWETAVGIEFMRLTVSDMLV
TYITILLGDFLRACFVRFMNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHE
RVFKASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPSFDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLANPGLIIPAILLMFLAIY
YLNSVSKSLSRANAQLRKKIQVLREVEKSHKSVKGKATARDSEDTPKSSSKNATQLQLTKEETTPPSASQSQAMDKKAQGPGTSNSASRT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RALGAPB-TMC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RALGAPB-TMC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RALGAPB-TMC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource