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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RANBP3-MLLT1 (FusionGDB2 ID:72081)

Fusion Gene Summary for RANBP3-MLLT1

check button Fusion gene summary
Fusion gene informationFusion gene name: RANBP3-MLLT1
Fusion gene ID: 72081
HgeneTgene
Gene symbol

RANBP3

MLLT1

Gene ID

8498

4298

Gene nameRAN binding protein 3MLLT1 super elongation complex subunit
Synonyms-ENL|LTG19|YEATS1
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionran-binding protein 3epididymis secretory sperm binding proteinprotein ENLCTC-503J8.6ENL/MLL fusionMLL/ENL fusion proteinMLLT1/MLL fusionYEATS domain-containing protein 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homol
Modification date2020031320200313
UniProtAcc.

Q13015

Ensembl transtripts involved in fusion geneENST00000034275, ENST00000340578, 
ENST00000439268, ENST00000541471, 
ENST00000591092, ENST00000591124, 
ENST00000585588, ENST00000252674, 
Fusion gene scores* DoF score10 X 6 X 8=48012 X 23 X 7=1932
# samples 1330
** MAII scorelog2(13/480*10)=-1.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/1932*10)=-2.68706068833989
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RANBP3 [Title/Abstract] AND MLLT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRANBP3(5924838)-MLLT1(6270770), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RANBP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MLLT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-8265-01ARANBP3chr19

5924838

-MLLT1chr19

6270770

-
ChimerDB4PRADTCGA-HC-8265RANBP3chr19

5924838

-MLLT1chr19

6270770

-


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Fusion Gene ORF analysis for RANBP3-MLLT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000034275ENST00000585588RANBP3chr19

5924838

-MLLT1chr19

6270770

-
5CDS-intronENST00000340578ENST00000585588RANBP3chr19

5924838

-MLLT1chr19

6270770

-
5CDS-intronENST00000439268ENST00000585588RANBP3chr19

5924838

-MLLT1chr19

6270770

-
5CDS-intronENST00000541471ENST00000585588RANBP3chr19

5924838

-MLLT1chr19

6270770

-
5CDS-intronENST00000591092ENST00000585588RANBP3chr19

5924838

-MLLT1chr19

6270770

-
In-frameENST00000034275ENST00000252674RANBP3chr19

5924838

-MLLT1chr19

6270770

-
In-frameENST00000340578ENST00000252674RANBP3chr19

5924838

-MLLT1chr19

6270770

-
In-frameENST00000439268ENST00000252674RANBP3chr19

5924838

-MLLT1chr19

6270770

-
In-frameENST00000541471ENST00000252674RANBP3chr19

5924838

-MLLT1chr19

6270770

-
In-frameENST00000591092ENST00000252674RANBP3chr19

5924838

-MLLT1chr19

6270770

-
intron-3CDSENST00000591124ENST00000252674RANBP3chr19

5924838

-MLLT1chr19

6270770

-
intron-intronENST00000591124ENST00000585588RANBP3chr19

5924838

-MLLT1chr19

6270770

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000439268RANBP3chr195924838-ENST00000252674MLLT1chr196270770-27621007262674882
ENST00000340578RANBP3chr195924838-ENST00000252674MLLT1chr196270770-28091054582721887
ENST00000541471RANBP3chr195924838-ENST00000252674MLLT1chr196270770-2425670582337759
ENST00000591092RANBP3chr195924838-ENST00000252674MLLT1chr196270770-2543788112455814
ENST00000034275RANBP3chr195924838-ENST00000252674MLLT1chr196270770-255179642463819

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000439268ENST00000252674RANBP3chr195924838-MLLT1chr196270770-0.0145754190.9854246
ENST00000340578ENST00000252674RANBP3chr195924838-MLLT1chr196270770-0.0149013940.9850986
ENST00000541471ENST00000252674RANBP3chr195924838-MLLT1chr196270770-0.038430210.9615698
ENST00000591092ENST00000252674RANBP3chr195924838-MLLT1chr196270770-0.0256438330.9743561
ENST00000034275ENST00000252674RANBP3chr195924838-MLLT1chr196270770-0.0249025470.9750974

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Fusion Genomic Features for RANBP3-MLLT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RANBP3-MLLT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5924838/chr19:6270770)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MLLT1

Q13015

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312). {ECO:0000269|PubMed:21715312, ECO:0000269|PubMed:26079538}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRANBP3chr19:5924838chr19:6270770ENST00000034275-101676_81264500.0Compositional biasNote=Poly-Pro
HgeneRANBP3chr19:5924838chr19:6270770ENST00000340578-111776_81332568.0Compositional biasNote=Poly-Pro
HgeneRANBP3chr19:5924838chr19:6270770ENST00000439268-111776_81327563.0Compositional biasNote=Poly-Pro
TgeneMLLT1chr19:5924838chr19:6270770ENST00000252674012272_2804560.0Compositional biasNote=Poly-Pro
TgeneMLLT1chr19:5924838chr19:6270770ENST00000252674012319_3254560.0Compositional biasNote=Poly-Ser
TgeneMLLT1chr19:5924838chr19:6270770ENST00000252674012374_3894560.0Compositional biasNote=Poly-Ser
TgeneMLLT1chr19:5924838chr19:6270770ENST00000252674012457_4604560.0Compositional biasNote=Poly-Pro
TgeneMLLT1chr19:5924838chr19:6270770ENST00000252674012463_4664560.0Compositional biasNote=Poly-Pro
TgeneMLLT1chr19:5924838chr19:6270770ENST000002526740121_1384560.0DomainYEATS
TgeneMLLT1chr19:5924838chr19:6270770ENST0000025267401256_584560.0RegionAcylated histone binding
TgeneMLLT1chr19:5924838chr19:6270770ENST0000025267401278_804560.0RegionAcylated histone binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRANBP3chr19:5924838chr19:6270770ENST00000034275-1016537_543264500.0Compositional biasNote=Poly-Asp
HgeneRANBP3chr19:5924838chr19:6270770ENST00000340578-1117537_543332568.0Compositional biasNote=Poly-Asp
HgeneRANBP3chr19:5924838chr19:6270770ENST00000439268-1117537_543327563.0Compositional biasNote=Poly-Asp
HgeneRANBP3chr19:5924838chr19:6270770ENST00000034275-1016378_518264500.0DomainRanBD1
HgeneRANBP3chr19:5924838chr19:6270770ENST00000340578-1117378_518332568.0DomainRanBD1
HgeneRANBP3chr19:5924838chr19:6270770ENST00000439268-1117378_518327563.0DomainRanBD1


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Fusion Gene Sequence for RANBP3-MLLT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72081_72081_1_RANBP3-MLLT1_RANBP3_chr19_5924838_ENST00000034275_MLLT1_chr19_6270770_ENST00000252674_length(transcript)=2551nt_BP=796nt
TAAAATGGCGGACCTGGCGAACGAAGAAAAGCCTGCCATTGCTCCGCCCGTCTTTGTGTTTCAGAAGGATAAAGGACAAAAGAGGTCAGC
TGGCGGCTCCAGTCCTGAAGGCGGAGAAGATTCTGACAGAGAAGATGGAAATTACTGCCCTCCTGTCAAGCGAGAAAGAACATCCTCTTT
AACCCAGTTCCCACCCTCACAGTCAGAGGAAAGGAGCAGTGGCTTCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCCCCAGCGC
AGGTCTGCCAAGCCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCGCAGCCAAAGGCGCTGTCCCA
GACTGTCCCCAGCAGTGGCACCAACGGGGTCAGCCTCCCAGCAGACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTGCTGCATG
GAGAAGTCCTTCCGAAGCTGCCGATGAGGTGTGTGCACTTGAGGAGAAAGAGCCCCAGAAAAATGAGTCCAGCAATGCCTCTGAAGAGGA
AGCCTGTGAGAAAAAAGACCCCGCCACACAGCAAGCCTTTGTATTTGGGCAGAACTTGAGGGACAGAGTTAAGCTGATAAATGAGAGCGT
GGACGAAGCCGACATGGAGAATGCTGGACACCCCAGCGCAGACACGCCAACCGCAACGAACTATTTCCTCCAGTATATCAGTTCCAGTTT
AGAGAACTCAACCAATAGTGCCGACGCCTCCAGCAACAAATTTGTATTTGGCCAGAACATGAGCGAGCGAGTTTTGTGCACCGTCCAGGT
GAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCACGACTGGATGGTGTTTGTCCGCGGCCC
CGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCCAAGCCCAGACGCGTGTGCAAGGAGCC
CCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAAAACAAGGAGGAGCCGAGGAAGGTCTG
CTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAGAAGCTCACCTTCAACAACCCCACCAC
GGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGTGATGGTAATGCCCGAAGGAGCAGACACGGTGTCCAGGCCCAGTCCCGACTACCC
CATGTTACCCACAATTCCACTCTCTGCCTTCTCTGACCCCAAGAAGACCAAACCATCCCACGGCTCCAAGGACGCCAACAAGGAGAGCAG
CAAGACCTCCAAGCCACACAAGGTGACCAAGGAGCACCGGGAGCGGCCCCGCAAAGACTCCGAGAGCAAGAGCTCCTCCAAGGAGCTGGA
GCGTGAGCAGGCCAAAAGCTCCAAGGACACCTCGCGGAAGCTGGGCGAGGGCCGGCTGCCCAAGGAGGAGAAGGCGCCACCGCCCAAGGC
TGCCTTCAAGGAACCCAAGATGGCCCTGAAAGAGACCAAGCTGGAAAGCACGTCCCCCAAGGGTGGGCCCCCACCCCCACCCCCACCCCC
ACCCCGGGCTTCCAGCAAGCGGCCGGCCACCGCCGACTCGCCAAAGCCCAGCGCCAAGAAGCAGAAGAAGAGCAGCTCGAAGGGGTCCCG
GAGTGCTCCAGGCACCTCGCCCCGCACCTCCTCCTCCTCCTCCTTCTCGGACAAGAAGCCGGCCAAGGACAAGAGCAGCACCAGAGGGGA
GAAGGTGAAGGCCGAGAGTGAGCCCCGGGAGGCCAAAAAGGCCCTGGAGGTGGAGGAGTCCAACTCAGAGGACGAGGCCTCCTTCAAGTC
CGAGTCTGCCCAGTCAAGCCCGTCCAACTCCAGCTCCAGCTCAGACTCCAGCTCAGACTCAGACTTCGAGCCATCCCAGAACCACAGCCA
AGGACCCCTGCGCTCCATGGTGGAGGACCTGCAGTCCGAGGAGTCCGACGAGGACGACTCTTCGTCAGGCGAGGAGGCTGCCGGCAAGAC
CAACCCGGGGAGGGACTCCAGGTTGAGCTTCAGCGACAGCGAGAGTGACAACAGCGCCGACTCCTCCCTGCCCAGCCGTGAGCCCCCACC
CCCCCAGAAGCCACCCCCGCCCAACAGCAAGGTGTCAGGCCGGAGGAGCCCCGAGTCCTGCAGCAAGCCTGAGAAGATCCTCAAGAAGGG
CACCTACGACAAGGCCTACACGGATGAGCTGGTGGAGCTACACCGGAGGCTGATGGCGCTGCGGGAGCGCAACGTGCTGCAGCAGATTGT
GAATCTGATCGAGGAGACTGGCCACTTCAATGTCACCAACACCACCTTCGACTTCGACCTCTTCTCCCTGGACGAGACCACCGTGCGCAA
ACTGCAGAGCTGCCTGGAGGCCGTGGCCACATGACCCTGGGCCGCGTGCCGGGCCCCCACCGCCGGGGTCCTGGGAGGCTGCAGCCAGGC

>72081_72081_1_RANBP3-MLLT1_RANBP3_chr19_5924838_ENST00000034275_MLLT1_chr19_6270770_ENST00000252674_length(amino acids)=819AA_BP=264
MADLANEEKPAIAPPVFVFQKDKGQKRSAGGSSPEGGEDSDREDGNYCPPVKRERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAG
LPSQKPKEQQRSVLRPAVLQAPQPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWRSPSEAADEVCALEEKEPQKNESSNASEEEA
CEKKDPATQQAFVFGQNLRDRVKLINESVDEADMENAGHPSADTPTATNYFLQYISSSLENSTNSADASSNKFVFGQNMSERVLCTVQVR
LELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCF
TYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSK
TSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPP
RASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSE
SAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPP
QKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKL

--------------------------------------------------------------
>72081_72081_2_RANBP3-MLLT1_RANBP3_chr19_5924838_ENST00000340578_MLLT1_chr19_6270770_ENST00000252674_length(transcript)=2809nt_BP=1054nt
AGAAAGCAGGCGAGCCTGGGCCGGCGCGGGGCCTTGTGGGAGGGCTTAAGGAAGTAAAATGGCGGACCTGGCGAACGAAGAAAAGCCTGC
CATTGCTCCGCCCGTCTTTGTGTTTCAGAAGGATAAAGGACAAAAGTCCCCTGCAGAGCAAAAAAACTTGTCGGATTCGGGAGAGGAGCC
TCGGGGGGAGGCTGAGGCCCCCCACCATGGCACGGGTCACCCCGAGTCAGCTGGCGAGCATGCCCTAGAACCTCCTGCCCCTGCTGGCGC
CTCAGCCAGCACTCCTCCGCCTCCCGCTCCTGAAGCCCAGCTTCCTCCTTTTCCGCGAGAACTGGCAGGGAGGTCAGCTGGCGGCTCCAG
TCCTGAAGGCGGAGAAGATTCTGACAGAGAAGATGGAAATTACTGCCCTCCTGTCAAGCGAGAAAGAACATCCTCTTTAACCCAGTTCCC
ACCCTCACAGTCAGAGGAAAGGAGCAGTGGCTTCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCCCCAGCGCAGGTCTGCCAAG
CCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCGCAGCCAAAGGCGCTGTCCCAGACTGTCCCCAG
CAGTGGCACCAACGGGGTCAGCCTCCCAGCAGACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTGCTGCATGGAGAAGTCCTTC
CGAAGCTGCCGATGAGGTGTGTGCACTTGAGGAGAAAGAGCCCCAGAAAAATGAGTCCAGCAATGCCTCTGAAGAGGAAGCCTGTGAGAA
AAAAGACCCCGCCACACAGCAAGCCTTTGTATTTGGGCAGAACTTGAGGGACAGAGTTAAGCTGATAAATGAGAGCGTGGACGAAGCCGA
CATGGAGAATGCTGGACACCCCAGCGCAGACACGCCAACCGCAACGAACTATTTCCTCCAGTATATCAGTTCCAGTTTAGAGAACTCAAC
CAATAGTGCCGACGCCTCCAGCAACAAATTTGTATTTGGCCAGAACATGAGCGAGCGAGTTTTGTGCACCGTCCAGGTGAGGTTAGAGCT
GGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCACGACTGGATGGTGTTTGTCCGCGGCCCCGAGCAATGTGA
CATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCCAAGCCCAGACGCGTGTGCAAGGAGCCCCCCTACAAAGT
AGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAAAACAAGGAGGAGCCGAGGAAGGTCTGCTTCACCTACGA
CCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAGAAGCTCACCTTCAACAACCCCACCACGGAGTTCCGGTA
CAAGCTCCTGCGGGCCGGCGGGGTGATGGTAATGCCCGAAGGAGCAGACACGGTGTCCAGGCCCAGTCCCGACTACCCCATGTTACCCAC
AATTCCACTCTCTGCCTTCTCTGACCCCAAGAAGACCAAACCATCCCACGGCTCCAAGGACGCCAACAAGGAGAGCAGCAAGACCTCCAA
GCCACACAAGGTGACCAAGGAGCACCGGGAGCGGCCCCGCAAAGACTCCGAGAGCAAGAGCTCCTCCAAGGAGCTGGAGCGTGAGCAGGC
CAAAAGCTCCAAGGACACCTCGCGGAAGCTGGGCGAGGGCCGGCTGCCCAAGGAGGAGAAGGCGCCACCGCCCAAGGCTGCCTTCAAGGA
ACCCAAGATGGCCCTGAAAGAGACCAAGCTGGAAAGCACGTCCCCCAAGGGTGGGCCCCCACCCCCACCCCCACCCCCACCCCGGGCTTC
CAGCAAGCGGCCGGCCACCGCCGACTCGCCAAAGCCCAGCGCCAAGAAGCAGAAGAAGAGCAGCTCGAAGGGGTCCCGGAGTGCTCCAGG
CACCTCGCCCCGCACCTCCTCCTCCTCCTCCTTCTCGGACAAGAAGCCGGCCAAGGACAAGAGCAGCACCAGAGGGGAGAAGGTGAAGGC
CGAGAGTGAGCCCCGGGAGGCCAAAAAGGCCCTGGAGGTGGAGGAGTCCAACTCAGAGGACGAGGCCTCCTTCAAGTCCGAGTCTGCCCA
GTCAAGCCCGTCCAACTCCAGCTCCAGCTCAGACTCCAGCTCAGACTCAGACTTCGAGCCATCCCAGAACCACAGCCAAGGACCCCTGCG
CTCCATGGTGGAGGACCTGCAGTCCGAGGAGTCCGACGAGGACGACTCTTCGTCAGGCGAGGAGGCTGCCGGCAAGACCAACCCGGGGAG
GGACTCCAGGTTGAGCTTCAGCGACAGCGAGAGTGACAACAGCGCCGACTCCTCCCTGCCCAGCCGTGAGCCCCCACCCCCCCAGAAGCC
ACCCCCGCCCAACAGCAAGGTGTCAGGCCGGAGGAGCCCCGAGTCCTGCAGCAAGCCTGAGAAGATCCTCAAGAAGGGCACCTACGACAA
GGCCTACACGGATGAGCTGGTGGAGCTACACCGGAGGCTGATGGCGCTGCGGGAGCGCAACGTGCTGCAGCAGATTGTGAATCTGATCGA
GGAGACTGGCCACTTCAATGTCACCAACACCACCTTCGACTTCGACCTCTTCTCCCTGGACGAGACCACCGTGCGCAAACTGCAGAGCTG
CCTGGAGGCCGTGGCCACATGACCCTGGGCCGCGTGCCGGGCCCCCACCGCCGGGGTCCTGGGAGGCTGCAGCCAGGCCTCGCCTGCCCT

>72081_72081_2_RANBP3-MLLT1_RANBP3_chr19_5924838_ENST00000340578_MLLT1_chr19_6270770_ENST00000252674_length(amino acids)=887AA_BP=332
MADLANEEKPAIAPPVFVFQKDKGQKSPAEQKNLSDSGEEPRGEAEAPHHGTGHPESAGEHALEPPAPAGASASTPPPPAPEAQLPPFPR
ELAGRSAGGSSPEGGEDSDREDGNYCPPVKRERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAP
QPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWRSPSEAADEVCALEEKEPQKNESSNASEEEACEKKDPATQQAFVFGQNLRDRV
KLINESVDEADMENAGHPSADTPTATNYFLQYISSSLENSTNSADASSNKFVFGQNMSERVLCTVQVRLELGHRAQLRKKPTTEGFTHDW
MVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKL
TFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESK
SSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKK
SSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFE
PSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKP

--------------------------------------------------------------
>72081_72081_3_RANBP3-MLLT1_RANBP3_chr19_5924838_ENST00000439268_MLLT1_chr19_6270770_ENST00000252674_length(transcript)=2762nt_BP=1007nt
CTTGTGGGAGGGCTTAAGGAAGTAAAATGGCGGACCTGGCGAACGAAGAAAAGCCTGCCATTGCTCCGCCCGTCTTTGTGTTTCAGAAGG
ATAAAGGACAAAAGTCCCCTGCAGAGCAAAAAAACTTGTCGGATTCGGGAGAGGAGCCTCGGGGGGAGGCTGAGGCCCCCCACCATGGCA
CGGGTCACCCCGAGTCAGCTGGCGAGCATGCCCTAGAACCTCCTGCCCCTGCTGGCGCCTCAGCCAGCACTCCTCCGCCTCCCGCTCCTG
AAGCCCAGCTTCCTCCTTTTCCGCGAGAACTGGCAGGGAGGTCAGCTGGCGGCTCCAGTCCTGAAGGCGGAGAAGATTCTGACAGAGAAG
ATGGAAATTACTGCCCTCCTGTCAAGCGAGAAAGAACATCCTCTTTAACCCAGTTCCCACCCTCACAGTCAGAGGAAAGGAGCAGTGGCT
TCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCCCCAGCGCAGGTCTGCCAAGCCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGC
TTCGCCCGGCAGTGTTACAAGCTCCGCAGCCAAAGGCGCTGTCCCAGACTGTCCCCAGCAGTGGCACCAACGGGGTCAGCCTCCCAGCAG
ACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTGCTGCATGGAGAAGTCCTTCCGAAGCTGCCGATGAGGAGAAAGAGCCCCAGA
AAAATGAGTCCAGCAATGCCTCTGAAGAGGAAGCCTGTGAGAAAAAAGACCCCGCCACACAGCAAGCCTTTGTATTTGGGCAGAACTTGA
GGGACAGAGTTAAGCTGATAAATGAGAGCGTGGACGAAGCCGACATGGAGAATGCTGGACACCCCAGCGCAGACACGCCAACCGCAACGA
ACTATTTCCTCCAGTATATCAGTTCCAGTTTAGAGAACTCAACCAATAGTGCCGACGCCTCCAGCAACAAATTTGTATTTGGCCAGAACA
TGAGCGAGCGAGTTTTGTGCACCGTCCAGGTGAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCA
CTCACGACTGGATGGTGTTTGTCCGCGGCCCCGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCT
TCCCCAAGCCCAGACGCGTGTGCAAGGAGCCCCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACT
TCAAAAACAAGGAGGAGCCGAGGAAGGTCTGCTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCT
GCGAGAAGCTCACCTTCAACAACCCCACCACGGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGTGATGGTAATGCCCGAAGGAGCAG
ACACGGTGTCCAGGCCCAGTCCCGACTACCCCATGTTACCCACAATTCCACTCTCTGCCTTCTCTGACCCCAAGAAGACCAAACCATCCC
ACGGCTCCAAGGACGCCAACAAGGAGAGCAGCAAGACCTCCAAGCCACACAAGGTGACCAAGGAGCACCGGGAGCGGCCCCGCAAAGACT
CCGAGAGCAAGAGCTCCTCCAAGGAGCTGGAGCGTGAGCAGGCCAAAAGCTCCAAGGACACCTCGCGGAAGCTGGGCGAGGGCCGGCTGC
CCAAGGAGGAGAAGGCGCCACCGCCCAAGGCTGCCTTCAAGGAACCCAAGATGGCCCTGAAAGAGACCAAGCTGGAAAGCACGTCCCCCA
AGGGTGGGCCCCCACCCCCACCCCCACCCCCACCCCGGGCTTCCAGCAAGCGGCCGGCCACCGCCGACTCGCCAAAGCCCAGCGCCAAGA
AGCAGAAGAAGAGCAGCTCGAAGGGGTCCCGGAGTGCTCCAGGCACCTCGCCCCGCACCTCCTCCTCCTCCTCCTTCTCGGACAAGAAGC
CGGCCAAGGACAAGAGCAGCACCAGAGGGGAGAAGGTGAAGGCCGAGAGTGAGCCCCGGGAGGCCAAAAAGGCCCTGGAGGTGGAGGAGT
CCAACTCAGAGGACGAGGCCTCCTTCAAGTCCGAGTCTGCCCAGTCAAGCCCGTCCAACTCCAGCTCCAGCTCAGACTCCAGCTCAGACT
CAGACTTCGAGCCATCCCAGAACCACAGCCAAGGACCCCTGCGCTCCATGGTGGAGGACCTGCAGTCCGAGGAGTCCGACGAGGACGACT
CTTCGTCAGGCGAGGAGGCTGCCGGCAAGACCAACCCGGGGAGGGACTCCAGGTTGAGCTTCAGCGACAGCGAGAGTGACAACAGCGCCG
ACTCCTCCCTGCCCAGCCGTGAGCCCCCACCCCCCCAGAAGCCACCCCCGCCCAACAGCAAGGTGTCAGGCCGGAGGAGCCCCGAGTCCT
GCAGCAAGCCTGAGAAGATCCTCAAGAAGGGCACCTACGACAAGGCCTACACGGATGAGCTGGTGGAGCTACACCGGAGGCTGATGGCGC
TGCGGGAGCGCAACGTGCTGCAGCAGATTGTGAATCTGATCGAGGAGACTGGCCACTTCAATGTCACCAACACCACCTTCGACTTCGACC
TCTTCTCCCTGGACGAGACCACCGTGCGCAAACTGCAGAGCTGCCTGGAGGCCGTGGCCACATGACCCTGGGCCGCGTGCCGGGCCCCCA

>72081_72081_3_RANBP3-MLLT1_RANBP3_chr19_5924838_ENST00000439268_MLLT1_chr19_6270770_ENST00000252674_length(amino acids)=882AA_BP=327
MADLANEEKPAIAPPVFVFQKDKGQKSPAEQKNLSDSGEEPRGEAEAPHHGTGHPESAGEHALEPPAPAGASASTPPPPAPEAQLPPFPR
ELAGRSAGGSSPEGGEDSDREDGNYCPPVKRERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAP
QPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWRSPSEAADEEKEPQKNESSNASEEEACEKKDPATQQAFVFGQNLRDRVKLINE
SVDEADMENAGHPSADTPTATNYFLQYISSSLENSTNSADASSNKFVFGQNMSERVLCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVR
GPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNP
TTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKE
LEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKG
SRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNH
SQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILK

--------------------------------------------------------------
>72081_72081_4_RANBP3-MLLT1_RANBP3_chr19_5924838_ENST00000541471_MLLT1_chr19_6270770_ENST00000252674_length(transcript)=2425nt_BP=670nt
AGAAAGCAGGCGAGCCTGGGCCGGCGCGGGGCCTTGTGGGAGGGCTTAAGGAAGTAAAATGGCGGACCTGGCGAACGAAGAGGAAAGGAG
CAGTGGCTTCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCCCCAGCGCAGGTCTGCCAAGCCAGAAGCCCAAGGAGCAGCAGCG
GAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCGCAGCCAAAGGCGCTGTCCCAGACTGTCCCCAGCAGTGGCACCAACGGGGTCAGCCT
CCCAGCAGACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTGCTGCATGGAGAAGTCCTTCCGAAGCTGCCGATGAGGTGTGTGC
ACTTGAGGAGAAAGAGCCCCAGAAAAATGAGTCCAGCAATGCCTCTGAAGAGGAAGCCTGTGAGAAAAAAGACCCCGCCACACAGCAAGC
CTTTGTATTTGGGCAGAACTTGAGGGACAGAGTTAAGCTGATAAATGAGAGCGTGGACGAAGCCGACATGGAGAATGCTGGACACCCCAG
CGCAGACACGCCAACCGCAACGAACTATTTCCTCCAGTATATCAGTTCCAGTTTAGAGAACTCAACCAATAGTGCCGACGCCTCCAGCAA
CAAATTTGTATTTGGCCAGAACATGAGCGAGCGAGTTTTGTGCACCGTCCAGGTGAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAA
GAAGCCCACCACGGAGGGGTTCACTCACGACTGGATGGTGTTTGTCCGCGGCCCCGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGT
GGTCTTCTGGCTGCACGACAGCTTCCCCAAGCCCAGACGCGTGTGCAAGGAGCCCCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTT
CATCATGCCCATCGAGGTGCACTTCAAAAACAAGGAGGAGCCGAGGAAGGTCTGCTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAA
CCCGCCCGTGAACCACCTGCGCTGCGAGAAGCTCACCTTCAACAACCCCACCACGGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGT
GATGGTAATGCCCGAAGGAGCAGACACGGTGTCCAGGCCCAGTCCCGACTACCCCATGTTACCCACAATTCCACTCTCTGCCTTCTCTGA
CCCCAAGAAGACCAAACCATCCCACGGCTCCAAGGACGCCAACAAGGAGAGCAGCAAGACCTCCAAGCCACACAAGGTGACCAAGGAGCA
CCGGGAGCGGCCCCGCAAAGACTCCGAGAGCAAGAGCTCCTCCAAGGAGCTGGAGCGTGAGCAGGCCAAAAGCTCCAAGGACACCTCGCG
GAAGCTGGGCGAGGGCCGGCTGCCCAAGGAGGAGAAGGCGCCACCGCCCAAGGCTGCCTTCAAGGAACCCAAGATGGCCCTGAAAGAGAC
CAAGCTGGAAAGCACGTCCCCCAAGGGTGGGCCCCCACCCCCACCCCCACCCCCACCCCGGGCTTCCAGCAAGCGGCCGGCCACCGCCGA
CTCGCCAAAGCCCAGCGCCAAGAAGCAGAAGAAGAGCAGCTCGAAGGGGTCCCGGAGTGCTCCAGGCACCTCGCCCCGCACCTCCTCCTC
CTCCTCCTTCTCGGACAAGAAGCCGGCCAAGGACAAGAGCAGCACCAGAGGGGAGAAGGTGAAGGCCGAGAGTGAGCCCCGGGAGGCCAA
AAAGGCCCTGGAGGTGGAGGAGTCCAACTCAGAGGACGAGGCCTCCTTCAAGTCCGAGTCTGCCCAGTCAAGCCCGTCCAACTCCAGCTC
CAGCTCAGACTCCAGCTCAGACTCAGACTTCGAGCCATCCCAGAACCACAGCCAAGGACCCCTGCGCTCCATGGTGGAGGACCTGCAGTC
CGAGGAGTCCGACGAGGACGACTCTTCGTCAGGCGAGGAGGCTGCCGGCAAGACCAACCCGGGGAGGGACTCCAGGTTGAGCTTCAGCGA
CAGCGAGAGTGACAACAGCGCCGACTCCTCCCTGCCCAGCCGTGAGCCCCCACCCCCCCAGAAGCCACCCCCGCCCAACAGCAAGGTGTC
AGGCCGGAGGAGCCCCGAGTCCTGCAGCAAGCCTGAGAAGATCCTCAAGAAGGGCACCTACGACAAGGCCTACACGGATGAGCTGGTGGA
GCTACACCGGAGGCTGATGGCGCTGCGGGAGCGCAACGTGCTGCAGCAGATTGTGAATCTGATCGAGGAGACTGGCCACTTCAATGTCAC
CAACACCACCTTCGACTTCGACCTCTTCTCCCTGGACGAGACCACCGTGCGCAAACTGCAGAGCTGCCTGGAGGCCGTGGCCACATGACC

>72081_72081_4_RANBP3-MLLT1_RANBP3_chr19_5924838_ENST00000541471_MLLT1_chr19_6270770_ENST00000252674_length(amino acids)=759AA_BP=204
MADLANEEERSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAPQPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWR
SPSEAADEVCALEEKEPQKNESSNASEEEACEKKDPATQQAFVFGQNLRDRVKLINESVDEADMENAGHPSADTPTATNYFLQYISSSLE
NSTNSADASSNKFVFGQNMSERVLCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPP
YKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPM
LPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAA
FKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEK
VKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTN
PGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVN

--------------------------------------------------------------
>72081_72081_5_RANBP3-MLLT1_RANBP3_chr19_5924838_ENST00000591092_MLLT1_chr19_6270770_ENST00000252674_length(transcript)=2543nt_BP=788nt
AAGGAAGTAAAATGGCGGACCTGGCGAACGAAGAAAAGCCTGCCATTGCTCCGCCCGTCTTTGTGTTTCAGAAGGATAAAGGACAAAAGA
GGTCAGCTGGCGGCTCCAGTCCTGAAGGCGGAGAAGATTCTGACAGAGAAGATGGAAATTACTGCCCTCCTGTCAAGCGAGAAAGAACAT
CCTCTTTAACCCAGTTCCCACCCTCACAGTCAGAGGAAAGGAGCAGTGGCTTCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCC
CCAGCGCAGGTCTGCCAAGCCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCGCAGCCAAAGGCGC
TGTCCCAGACTGTCCCCAGCAGTGGCACCAACGGGGTCAGCCTCCCAGCAGACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTG
CTGCATGGAGAAGTCCTTCCGAAGCTGCCGATGAGGAGAAAGAGCCCCAGAAAAATGAGTCCAGCAATGCCTCTGAAGAGGAAGCCTGTG
AGAAAAAAGACCCCGCCACACAGCAAGCCTTTGTATTTGGGCAGAACTTGAGGGACAGAGTTAAGCTGATAAATGAGAGCGTGGACGAAG
CCGACATGGAGAATGCTGGACACCCCAGCGCAGACACGCCAACCGCAACGAACTATTTCCTCCAGTATATCAGTTCCAGTTTAGAGAACT
CAACCAATAGTGCCGACGCCTCCAGCAACAAATTTGTATTTGGCCAGAACATGAGCGAGCGAGTTTTGTGCACCGTCCAGGTGAGGTTAG
AGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCACGACTGGATGGTGTTTGTCCGCGGCCCCGAGCAAT
GTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCCAAGCCCAGACGCGTGTGCAAGGAGCCCCCCTACA
AAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAAAACAAGGAGGAGCCGAGGAAGGTCTGCTTCACCT
ACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAGAAGCTCACCTTCAACAACCCCACCACGGAGTTCC
GGTACAAGCTCCTGCGGGCCGGCGGGGTGATGGTAATGCCCGAAGGAGCAGACACGGTGTCCAGGCCCAGTCCCGACTACCCCATGTTAC
CCACAATTCCACTCTCTGCCTTCTCTGACCCCAAGAAGACCAAACCATCCCACGGCTCCAAGGACGCCAACAAGGAGAGCAGCAAGACCT
CCAAGCCACACAAGGTGACCAAGGAGCACCGGGAGCGGCCCCGCAAAGACTCCGAGAGCAAGAGCTCCTCCAAGGAGCTGGAGCGTGAGC
AGGCCAAAAGCTCCAAGGACACCTCGCGGAAGCTGGGCGAGGGCCGGCTGCCCAAGGAGGAGAAGGCGCCACCGCCCAAGGCTGCCTTCA
AGGAACCCAAGATGGCCCTGAAAGAGACCAAGCTGGAAAGCACGTCCCCCAAGGGTGGGCCCCCACCCCCACCCCCACCCCCACCCCGGG
CTTCCAGCAAGCGGCCGGCCACCGCCGACTCGCCAAAGCCCAGCGCCAAGAAGCAGAAGAAGAGCAGCTCGAAGGGGTCCCGGAGTGCTC
CAGGCACCTCGCCCCGCACCTCCTCCTCCTCCTCCTTCTCGGACAAGAAGCCGGCCAAGGACAAGAGCAGCACCAGAGGGGAGAAGGTGA
AGGCCGAGAGTGAGCCCCGGGAGGCCAAAAAGGCCCTGGAGGTGGAGGAGTCCAACTCAGAGGACGAGGCCTCCTTCAAGTCCGAGTCTG
CCCAGTCAAGCCCGTCCAACTCCAGCTCCAGCTCAGACTCCAGCTCAGACTCAGACTTCGAGCCATCCCAGAACCACAGCCAAGGACCCC
TGCGCTCCATGGTGGAGGACCTGCAGTCCGAGGAGTCCGACGAGGACGACTCTTCGTCAGGCGAGGAGGCTGCCGGCAAGACCAACCCGG
GGAGGGACTCCAGGTTGAGCTTCAGCGACAGCGAGAGTGACAACAGCGCCGACTCCTCCCTGCCCAGCCGTGAGCCCCCACCCCCCCAGA
AGCCACCCCCGCCCAACAGCAAGGTGTCAGGCCGGAGGAGCCCCGAGTCCTGCAGCAAGCCTGAGAAGATCCTCAAGAAGGGCACCTACG
ACAAGGCCTACACGGATGAGCTGGTGGAGCTACACCGGAGGCTGATGGCGCTGCGGGAGCGCAACGTGCTGCAGCAGATTGTGAATCTGA
TCGAGGAGACTGGCCACTTCAATGTCACCAACACCACCTTCGACTTCGACCTCTTCTCCCTGGACGAGACCACCGTGCGCAAACTGCAGA
GCTGCCTGGAGGCCGTGGCCACATGACCCTGGGCCGCGTGCCGGGCCCCCACCGCCGGGGTCCTGGGAGGCTGCAGCCAGGCCTCGCCTG

>72081_72081_5_RANBP3-MLLT1_RANBP3_chr19_5924838_ENST00000591092_MLLT1_chr19_6270770_ENST00000252674_length(amino acids)=814AA_BP=259
MADLANEEKPAIAPPVFVFQKDKGQKRSAGGSSPEGGEDSDREDGNYCPPVKRERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAG
LPSQKPKEQQRSVLRPAVLQAPQPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWRSPSEAADEEKEPQKNESSNASEEEACEKKD
PATQQAFVFGQNLRDRVKLINESVDEADMENAGHPSADTPTATNYFLQYISSSLENSTNSADASSNKFVFGQNMSERVLCTVQVRLELGH
RAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLF
LNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPH
KVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSK
RPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSS
PSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPP
PNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSCLE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RANBP3-MLLT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RANBP3-MLLT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RANBP3-MLLT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource