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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RANGAP1-ARHGAP8 (FusionGDB2 ID:72103)

Fusion Gene Summary for RANGAP1-ARHGAP8

check button Fusion gene summary
Fusion gene informationFusion gene name: RANGAP1-ARHGAP8
Fusion gene ID: 72103
HgeneTgene
Gene symbol

RANGAP1

ARHGAP8

Gene ID

5905

23779

Gene nameRan GTPase activating protein 1Rho GTPase activating protein 8
SynonymsFug1|RANGAP|SDBPGAP1|PP610
Cytomap

22q13.2

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionran GTPase-activating protein 1segregation distorter homologsegregation distortionrho GTPase-activating protein 8BCH domain-containing Cdc42GAP-like proteinBNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1rho-type GTPase-activating protein 8
Modification date2020031320200313
UniProtAcc.

P85298

Ensembl transtripts involved in fusion geneENST00000356244, ENST00000405486, 
ENST00000407260, ENST00000455915, 
ENST00000469872, ENST00000336963, 
ENST00000356099, ENST00000389774, 
ENST00000389773, ENST00000517296, 
Fusion gene scores* DoF score16 X 14 X 7=15686 X 9 X 5=270
# samples 187
** MAII scorelog2(18/1568*10)=-3.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/270*10)=-1.94753258010586
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RANGAP1 [Title/Abstract] AND ARHGAP8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRANGAP1(41670604)-ARHGAP8(45182337), # samples:2
Anticipated loss of major functional domain due to fusion event.RANGAP1-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRANGAP1

GO:0046826

negative regulation of protein export from nucleus

16449645

HgeneRANGAP1

GO:0090630

activation of GTPase activity

16428860

TgeneARHGAP8

GO:0070374

positive regulation of ERK1 and ERK2 cascade

20179103


check buttonFusion gene breakpoints across RANGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGAP8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FS-A4F4-06ARANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+


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Fusion Gene ORF analysis for RANGAP1-ARHGAP8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000356244ENST00000469872RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-3UTRENST00000405486ENST00000469872RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-3UTRENST00000407260ENST00000469872RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-3UTRENST00000455915ENST00000469872RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-5UTRENST00000356244ENST00000336963RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-5UTRENST00000356244ENST00000356099RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-5UTRENST00000356244ENST00000389774RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-5UTRENST00000405486ENST00000336963RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-5UTRENST00000405486ENST00000356099RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-5UTRENST00000405486ENST00000389774RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-5UTRENST00000407260ENST00000336963RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-5UTRENST00000407260ENST00000356099RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-5UTRENST00000407260ENST00000389774RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-5UTRENST00000455915ENST00000336963RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-5UTRENST00000455915ENST00000356099RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
5CDS-5UTRENST00000455915ENST00000389774RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
Frame-shiftENST00000356244ENST00000389773RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
Frame-shiftENST00000356244ENST00000517296RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
Frame-shiftENST00000407260ENST00000389773RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
Frame-shiftENST00000407260ENST00000517296RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
Frame-shiftENST00000455915ENST00000389773RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
Frame-shiftENST00000455915ENST00000517296RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
In-frameENST00000405486ENST00000389773RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+
In-frameENST00000405486ENST00000517296RANGAP1chr22

41670604

-ARHGAP8chr22

45182337

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000405486RANGAP1chr2241670604-ENST00000517296ARHGAP8chr2245182337+23059539552193412
ENST00000405486RANGAP1chr2241670604-ENST00000389773ARHGAP8chr2245182337+25159539552325456

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000405486ENST00000517296RANGAP1chr2241670604-ARHGAP8chr2245182337+0.0521371030.94786286
ENST00000405486ENST00000389773RANGAP1chr2241670604-ARHGAP8chr2245182337+0.0275850020.972415

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Fusion Genomic Features for RANGAP1-ARHGAP8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RANGAP1chr2241670603-ARHGAP8chr2245182336+2.58E-091
RANGAP1chr2241670603-ARHGAP8chr2245182336+2.58E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RANGAP1-ARHGAP8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:41670604/chr22:45182337)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARHGAP8

P85298

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000356244-31648_7180588.0RepeatNote=LRR 1
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000405486-41748_7180588.0RepeatNote=LRR 1
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000455915-21548_7180588.0RepeatNote=LRR 1
TgeneARHGAP8chr22:41670604chr22:45182337ENST0000035609901213_1990434.0DomainCRAL-TRIO
TgeneARHGAP8chr22:41670604chr22:45182337ENST00000356099012226_4120434.0DomainRho-GAP
TgeneARHGAP8chr22:41670604chr22:45182337ENST0000038977401313_1990465.0DomainCRAL-TRIO
TgeneARHGAP8chr22:41670604chr22:45182337ENST00000389774013226_4120465.0DomainRho-GAP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000356244-316359_39780588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000356244-316359_39980588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000405486-417359_39780588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000405486-417359_39980588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000455915-215359_39780588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000455915-215359_39980588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000356244-316523_52680588.0MotifNote=SUMO conjugation
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000405486-417523_52680588.0MotifNote=SUMO conjugation
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000455915-215523_52680588.0MotifNote=SUMO conjugation
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000356244-316111_13480588.0RepeatNote=LRR 2
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000356244-316207_23080588.0RepeatNote=LRR 3
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000356244-316235_25880588.0RepeatNote=LRR 4
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000356244-316292_31980588.0RepeatNote=LRR 5
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000356244-316320_34380588.0RepeatNote=LRR 6
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000405486-417111_13480588.0RepeatNote=LRR 2
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000405486-417207_23080588.0RepeatNote=LRR 3
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000405486-417235_25880588.0RepeatNote=LRR 4
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000405486-417292_31980588.0RepeatNote=LRR 5
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000405486-417320_34380588.0RepeatNote=LRR 6
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000455915-215111_13480588.0RepeatNote=LRR 2
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000455915-215207_23080588.0RepeatNote=LRR 3
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000455915-215235_25880588.0RepeatNote=LRR 4
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000455915-215292_31980588.0RepeatNote=LRR 5
HgeneRANGAP1chr22:41670604chr22:45182337ENST00000455915-215320_34380588.0RepeatNote=LRR 6


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Fusion Gene Sequence for RANGAP1-ARHGAP8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72103_72103_1_RANGAP1-ARHGAP8_RANGAP1_chr22_41670604_ENST00000405486_ARHGAP8_chr22_45182337_ENST00000389773_length(transcript)=2515nt_BP=953nt
CTTTCCCCGTCACCTGCCTGGAACAGGGGTGCGGGGCGAGGAGGGCGTGGCGCCCGTGTGCGCCTTCTGCCTGCCCCCTCGGCCTTCTTC
ACTTAGCCTTCGACGGCCGAGCGCCCCAGGGGTGGCGGTGGGAGTGGGGTTGTTGAGCGGCGCTGGCTCCTTTCACAAATGGGGAAACTG
AGGCTTAAAGGGCGTCTGACTCGCCAGAGCAGCTCAGCCTGCAGCTGCTAGCAGTGGCGTCTCATATTAGCATTGTTGTCAACCGGAGGC
GGTGCGAGTCCGCCGGGGATTCCAGATGGGGCTCCTGCGCCGCCCGCCTATCATTTGCGGCCTGTATTCGCGCGTCGCTCCCGCAGAGCC
ACCTCCCAGCAGGCCCACGCCCGCGGGGGCCCCGGGCTGGCGCCGCTGTCCCTGGAATCGATAGACGGTCTCCTTCTGTCACCCAGGCTG
GAGTGTAGTGGAACGATCACCGCTGAACTGCAGCGTCGGCTTCCTGGGCTCAAGCGATCCTCCCACCTCAACCTCCCAAGTCATGGGGAC
TACAGATGCCATCACACCTGGCTAATTTTTAAATTTTTCTGTGGAGACAGGGTCTCATTCTGTTGCCCAGGCTTGTCTCGAACCCTGGTC
TAAAGTGATCTTCCCGCCTAGCCTCCCAAAATGTTGGAATTACAGTCTGCAGATCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCT
CGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCA
ACACTGCAGAAGATGCTAAAGATGTGATTAAAGAGATTGAAGACTTTGACAGCTTGGAGGCTCTGCGTCTGGAAGGCAACACAGTGGGCG
TGGAAGCAGCCAGGGTCATCGCCAAGGCCTTAGAGAAGAAGTCGGAGTTGAAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCT
GGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAG
ACATGGCATTCTGCAGGTGGCAGGGGATGACCGCTTTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATGCCACCCTCCCACGAGCT
GGACCACCAGCGGCTGCTGGAGTATTTGAAGTACACACTGGACCAATACGTTGAGAACGATTATACCATCGTCTATTTCCACTACGGGCT
GAACAGCCGGAACAAGCCTTCCCTGGGCTGGCTCCAGAGCGCATACAAGGAGTTCGATAGGAAGTACAAGAAGAACTTGAAGGCCCTCTA
CGTGGTGCACCCCACCAGCTTCATCAAGGTCCTGTGGAACATCTTGAAGCCCCTCATCAGTCACAAGTTTGGGAAGAAAGTCATCTATTT
CAACTACCTGAGTGAGCTCCACGAACACCTTAAATACGACCAGCTGGTCATCCCTCCCGAAGTTTTGCGGTACGATGAGAAGCTCCAGAG
CCTGCACGAGGGCCGGACGCCGCCTCCCACCAAGACACCACCGCCGCGGCCCCCGCTGCCCACACAGCAGTTTGGCGTCAGTCTGCAATA
CCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGG
CCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGG
GGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCT
CGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCAGATCTTACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCG
CTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAA
TTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAA
GATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCC
ACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTC
TGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAAAAATAACCAGCCATTAGATGAA

>72103_72103_1_RANGAP1-ARHGAP8_RANGAP1_chr22_41670604_ENST00000405486_ARHGAP8_chr22_45182337_ENST00000389773_length(amino acids)=456AA_BP=1
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVE
NDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVIP
PEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLY
NQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKM
NSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLM

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>72103_72103_2_RANGAP1-ARHGAP8_RANGAP1_chr22_41670604_ENST00000405486_ARHGAP8_chr22_45182337_ENST00000517296_length(transcript)=2305nt_BP=953nt
CTTTCCCCGTCACCTGCCTGGAACAGGGGTGCGGGGCGAGGAGGGCGTGGCGCCCGTGTGCGCCTTCTGCCTGCCCCCTCGGCCTTCTTC
ACTTAGCCTTCGACGGCCGAGCGCCCCAGGGGTGGCGGTGGGAGTGGGGTTGTTGAGCGGCGCTGGCTCCTTTCACAAATGGGGAAACTG
AGGCTTAAAGGGCGTCTGACTCGCCAGAGCAGCTCAGCCTGCAGCTGCTAGCAGTGGCGTCTCATATTAGCATTGTTGTCAACCGGAGGC
GGTGCGAGTCCGCCGGGGATTCCAGATGGGGCTCCTGCGCCGCCCGCCTATCATTTGCGGCCTGTATTCGCGCGTCGCTCCCGCAGAGCC
ACCTCCCAGCAGGCCCACGCCCGCGGGGGCCCCGGGCTGGCGCCGCTGTCCCTGGAATCGATAGACGGTCTCCTTCTGTCACCCAGGCTG
GAGTGTAGTGGAACGATCACCGCTGAACTGCAGCGTCGGCTTCCTGGGCTCAAGCGATCCTCCCACCTCAACCTCCCAAGTCATGGGGAC
TACAGATGCCATCACACCTGGCTAATTTTTAAATTTTTCTGTGGAGACAGGGTCTCATTCTGTTGCCCAGGCTTGTCTCGAACCCTGGTC
TAAAGTGATCTTCCCGCCTAGCCTCCCAAAATGTTGGAATTACAGTCTGCAGATCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCT
CGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCA
ACACTGCAGAAGATGCTAAAGATGTGATTAAAGAGATTGAAGACTTTGACAGCTTGGAGGCTCTGCGTCTGGAAGGCAACACAGTGGGCG
TGGAAGCAGCCAGGGTCATCGCCAAGGCCTTAGAGAAGAAGTCGGAGTTGAAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCT
GGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAG
ACATGGCATTCTGCAGGTGGCAGGGGATGACCGCTTTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATGCCACCCTCCCACGAGCT
GGACCACCAGCGGCTGCTGGAGTACAAGAAGAACTTGAAGGCCCTCTACGTGGTGCACCCCACCAGCTTCATCAAGGTCCTGTGGAACAT
CTTGAAGCCCCTCATCAGTCACAAGTTTGGGAAGAAAGTCATCTATTTCAACTACCTGAGTGAGCTCCACGAACACCTTAAATACGACCA
GCTGGTCATCCCTCCCGAAGTTTTGCGGTACGATGAGAAGCTCCAGAGCCTGCACGAGGGCCGGACGCCGCCTCCCACCAAGACACCACC
GCCGCGGCCCCCGCTGCCCACACAGCAGTTTGGCGTCAGTCTGCAATACCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCT
GAGGTTCACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGAT
CCAGAGGCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCG
AGAGCTGCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTG
CCGCCAGATCTTACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCAT
CTTCAACAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCT
TGTGCCCCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGC
ACCATGGGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCC
GAGTCCCCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGT

>72103_72103_2_RANGAP1-ARHGAP8_RANGAP1_chr22_41670604_ENST00000405486_ARHGAP8_chr22_45182337_ENST00000517296_length(amino acids)=412AA_BP=1
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYKKNLKALYVV
HPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLK
DKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGI
TCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIF

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Fusion Gene PPI Analysis for RANGAP1-ARHGAP8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RANGAP1-ARHGAP8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RANGAP1-ARHGAP8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource