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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RANGAP1-FAM53A (FusionGDB2 ID:72109)

Fusion Gene Summary for RANGAP1-FAM53A

Fusion gene summary

Fusion gene information	Fusion gene name: RANGAP1-FAM53A
	Fusion gene ID: 72109
		Hgene	Tgene
	Gene symbol	RANGAP1	FAM53A
	Gene ID	5905	152877
	Gene name	Ran GTPase activating protein 1	family with sequence similarity 53 member A
	Synonyms	Fug1\|RANGAP\|SD	DNTNP
	Cytomap	22q13.2	4p16.3
	Type of gene	protein-coding	protein-coding
	Description	ran GTPase-activating protein 1segregation distorter homologsegregation distortion	protein FAM53Adorsal neural-tube nuclear protein
	Modification date	20200313	20200313
	UniProtAcc	.	Q6NSI3
	Ensembl transtripts involved in fusion gene	ENST00000356244, ENST00000405486, ENST00000455915, ENST00000407260,	ENST00000461064, ENST00000308132, ENST00000472884, ENST00000489363,
Fusion gene scores	* DoF score	16 X 14 X 7=1568	4 X 3 X 4=48
	# samples	18	4
	** MAII score	log2(18/1568*10)=-3.12285674778553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RANGAP1 [Title/Abstract] AND FAM53A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RANGAP1(41676937)-FAM53A(1643334), # samples:1
Anticipated loss of major functional domain due to fusion event.	RANGAP1-FAM53A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RANGAP1	GO:0046826	negative regulation of protein export from nucleus	16449645
Hgene	RANGAP1	GO:0090630	activation of GTPase activity	16428860

Fusion gene breakpoints across RANGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FAM53A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-EE-A2ME-06A	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-

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Fusion Gene ORF analysis for RANGAP1-FAM53A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000356244	ENST00000461064	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
Frame-shift	ENST00000405486	ENST00000308132	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
Frame-shift	ENST00000405486	ENST00000472884	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
Frame-shift	ENST00000405486	ENST00000489363	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
Frame-shift	ENST00000455915	ENST00000461064	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
In-frame	ENST00000356244	ENST00000308132	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
In-frame	ENST00000356244	ENST00000472884	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
In-frame	ENST00000356244	ENST00000489363	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
In-frame	ENST00000405486	ENST00000461064	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
In-frame	ENST00000455915	ENST00000308132	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
In-frame	ENST00000455915	ENST00000472884	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
In-frame	ENST00000455915	ENST00000489363	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
intron-3CDS	ENST00000407260	ENST00000308132	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
intron-3CDS	ENST00000407260	ENST00000461064	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
intron-3CDS	ENST00000407260	ENST00000472884	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-
intron-3CDS	ENST00000407260	ENST00000489363	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000405486	RANGAP1	chr22	41676937	-	ENST00000461064	FAM53A	chr4	1643334	-	1938	825	1655	837	272
ENST00000356244	RANGAP1	chr22	41676937	-	ENST00000308132	FAM53A	chr4	1643334	-	2143	416	1246	428	272
ENST00000356244	RANGAP1	chr22	41676937	-	ENST00000489363	FAM53A	chr4	1643334	-	1558	416	1246	428	272
ENST00000356244	RANGAP1	chr22	41676937	-	ENST00000472884	FAM53A	chr4	1643334	-	1422	416	1246	428	272
ENST00000455915	RANGAP1	chr22	41676937	-	ENST00000308132	FAM53A	chr4	1643334	-	3309	1582	2412	1594	272
ENST00000455915	RANGAP1	chr22	41676937	-	ENST00000489363	FAM53A	chr4	1643334	-	2724	1582	2412	1594	272
ENST00000455915	RANGAP1	chr22	41676937	-	ENST00000472884	FAM53A	chr4	1643334	-	2588	1582	2412	1594	272

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000405486	ENST00000461064	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-	0.14333574	0.85666424
ENST00000356244	ENST00000308132	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-	0.10094464	0.89905536
ENST00000356244	ENST00000489363	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-	0.026304256	0.97369576
ENST00000356244	ENST00000472884	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-	0.032436945	0.96756303
ENST00000455915	ENST00000308132	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-	0.13677734	0.86322266
ENST00000455915	ENST00000489363	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-	0.16460177	0.83539826
ENST00000455915	ENST00000472884	RANGAP1	chr22	41676937	-	FAM53A	chr4	1643334	-	0.23056237	0.7694376

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Fusion Genomic Features for RANGAP1-FAM53A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RANGAP1-FAM53A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:41676937/chr4:1643334)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FAM53A Q6NSI3
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: May play an important role in neural development; the dorsomedial roof of the third ventricle. {ECO:0000250\|UniProtKB:Q5ZKN5}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000356244

359_397

588.0

Compositional bias

Note=Asp/Glu-rich (highly acidic)

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000356244

359_399

588.0

Compositional bias

Note=Asp/Glu-rich (highly acidic)

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000405486

359_397

588.0

Compositional bias

Note=Asp/Glu-rich (highly acidic)

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000405486

359_399

588.0

Compositional bias

Note=Asp/Glu-rich (highly acidic)

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000455915

359_397

588.0

Compositional bias

Note=Asp/Glu-rich (highly acidic)

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000455915

359_399

588.0

Compositional bias

Note=Asp/Glu-rich (highly acidic)

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000356244

523_526

588.0

Motif

Note=SUMO conjugation

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000405486

523_526

588.0

Motif

Note=SUMO conjugation

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000455915

523_526

588.0

Motif

Note=SUMO conjugation

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000356244

111_134

588.0

Repeat

Note=LRR 2

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000356244

207_230

588.0

Repeat

Note=LRR 3

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000356244

235_258

588.0

Repeat

Note=LRR 4

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000356244

292_319

588.0

Repeat

Note=LRR 5

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000356244

320_343

588.0

Repeat

Note=LRR 6

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000356244

48_71

588.0

Repeat

Note=LRR 1

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000405486

111_134

588.0

Repeat

Note=LRR 2

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000405486

207_230

588.0

Repeat

Note=LRR 3

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000405486

235_258

588.0

Repeat

Note=LRR 4

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000405486

292_319

588.0

Repeat

Note=LRR 5

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000405486

320_343

588.0

Repeat

Note=LRR 6

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000405486

48_71

588.0

Repeat

Note=LRR 1

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000455915

111_134

588.0

Repeat

Note=LRR 2

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000455915

207_230

588.0

Repeat

Note=LRR 3

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000455915

235_258

588.0

Repeat

Note=LRR 4

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000455915

292_319

588.0

Repeat

Note=LRR 5

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000455915

320_343

588.0

Repeat

Note=LRR 6

Hgene

RANGAP1

chr22:41676937

chr4:1643334

ENST00000455915

48_71

588.0

Repeat

Note=LRR 1

Tgene

FAM53A

chr22:41676937

chr4:1643334

ENST00000308132

268_276

294

399.0

Motif

Nuclear localization signal

Tgene

FAM53A

chr22:41676937

chr4:1643334

ENST00000461064

268_276

294

399.0

Motif

Nuclear localization signal

Tgene

FAM53A

chr22:41676937

chr4:1643334

ENST00000472884

268_276

294

399.0

Motif

Nuclear localization signal

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Fusion Gene Sequence for RANGAP1-FAM53A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>72109_72109_1_RANGAP1-FAM53A_RANGAP1_chr22_41676937_ENST00000356244_FAM53A_chr4_1643334_ENST00000308132_length(transcript)=2143nt_BP=416nt
GAACAAATCAAATCGAAGCAAAGAAACTGCCGGCTTTCAAAATCCTCCTCCTCCGCCATCATCCGCCGCGGTGCGGAGAGCAGGTGGTGC
TGGAAGCGCGTGAGGCCGGGAGCTCGAGAGAGCTAACAGACTAGCCGGCTGGACATCTGGACCGCTGGATCCGGAGGTGGCGACCCCGGC
CTGACCCGGACCCTAAATCCGTCCCCGCCCCAGAGGGCGGAGGCGCGCGCTCGATTCCCCCCACGCGGCGGCGCCGCCTGTTTACGTCTG
CAGATCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGC
CGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCA
ATTACGAAGATGACGATGAGGATGACACCCCAGTGAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGC
CTGGCTGCAGCCAGAGGGGCCTCAGGACCAGCCCTGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCA
GGAGCAGCGGGGACCCCCGTGATGGGGACAGTGTCGGGGAGGAGGGCGTCTTCCCCCGGGCCCGCTGGGAGCTGGACCTGGAGCAGATCG
AGAACAACTGAGGCTGGTGGGGGCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGT
CGGGGCCACGGCCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGG
GGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGG
TCGGGGCCACGGCTGCCACCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCTGCACTGC
CCTGGGGCACAGACTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCTGCCTGCACCTGCCCCAGGGCACAGAGTAGGTTTCCTGTGA
GCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCCGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCACCGGC
ACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGTTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCA
TGTGAGCTGGTCGGGGCCATGGCTGCTGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCGTGTTGCTTGGAACATTAAGGCGTAATTT
TGATTCAGTTTTTCCTAAAGAAGCATTTTGCATTTTTATGGCTTTTGCAGTTCGGGAGAAAGCTTCTCTATTTTGGATGCATTTCAGAAG
GGCGTTCTATTAAACATGAATCTGCAAACAGATTAACATGCGTCTGTGTTCCCCACGAAAGGCCTGCTGTGCAGGGCGCCTTGTGTGCTT
TAGTTGCTAGGAAACCCCGGGCGTTGGTGGTCAGAGTCCCACTGGCCCCGTGTGTCCCCCCCTCCCGACGGGTCACGGTGCTTGGGGCTT
GCGCATGGGCATCTGTGCCCATGAACCTTGTCACCCACGTGCCAGTGAACCGCCAGCTTGTGGCCGCCTGGTTTTCCACCGGTGGCAGTG
ATGGCCTTTGGGGCAGACCAAGGTGCCATGAGTCCCTGCTTCCCGTGGCCTGGGAGGGCCCTTGCACCTTCAGGTGGGGTGTAGTGCCAG
ACCTCTGGGAAGGCTGTCCTGCCGGCAGCACCCGTCAGCACCCACTCTGTGAATTTAATACAAGGCCTTTGCTTTGTGCATACGACTTCT
GATTAATTTTCGTTTCCACCATCTGAAGTGGGCCTGGCTGCGCCTCAGGCCTCTGGTCTCTGGCTCAGAACCAGACAAGGCAAGGGATTT

>72109_72109_1_RANGAP1-FAM53A_RANGAP1_chr22_41676937_ENST00000356244_FAM53A_chr4_1643334_ENST00000308132_length(amino acids)=272AA_BP=1
MAPTSSQETYSVPRGRCRRQPWPRPAHRKPTLCPGAGAGSSHGPDQLTGNLVCAPGQCRRQPWPRPAHRKPTLCPRAGAGGSRGPDQLTG
NLLCAPGQVPAAAVAPTSSQETYSVPQGRCRRQPWPRPAHRKPTLCPRAGAGPWPRPAHRKPTLCPRAGAGGSHGPDQPPPASVVLDLLQ
VQLPAGPGEDALLPDTVPITGVPAAPAGAITGHRLPRGPQVGVDRAGPEAPLAAARHGDAREAPGVTWGGQNRLHWGVILIVIFVIEGAK

--------------------------------------------------------------
>72109_72109_2_RANGAP1-FAM53A_RANGAP1_chr22_41676937_ENST00000356244_FAM53A_chr4_1643334_ENST00000472884_length(transcript)=1422nt_BP=416nt
GAACAAATCAAATCGAAGCAAAGAAACTGCCGGCTTTCAAAATCCTCCTCCTCCGCCATCATCCGCCGCGGTGCGGAGAGCAGGTGGTGC
TGGAAGCGCGTGAGGCCGGGAGCTCGAGAGAGCTAACAGACTAGCCGGCTGGACATCTGGACCGCTGGATCCGGAGGTGGCGACCCCGGC
CTGACCCGGACCCTAAATCCGTCCCCGCCCCAGAGGGCGGAGGCGCGCGCTCGATTCCCCCCACGCGGCGGCGCCGCCTGTTTACGTCTG
CAGATCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGC
CGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCA
ATTACGAAGATGACGATGAGGATGACACCCCAGTGAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGC
CTGGCTGCAGCCAGAGGGGCCTCAGGACCAGCCCTGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCA
GGAGCAGCGGGGACCCCCGTGATGGGGACAGTGTCGGGGAGGAGGGCGTCTTCCCCCGGGCCCGCTGGGAGCTGGACCTGGAGCAGATCG
AGAACAACTGAGGCTGGTGGGGGCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGT
CGGGGCCACGGCCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGG
GGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGG
TCGGGGCCACGGCTGCCACCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCTGCACTGC
CCTGGGGCACAGACTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCTGCCTGCACCTGCCCCAGGGCACAGAGTAGGTTTCCTGTGA
GCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCCGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCACCGGC
ACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGTTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCA

>72109_72109_2_RANGAP1-FAM53A_RANGAP1_chr22_41676937_ENST00000356244_FAM53A_chr4_1643334_ENST00000472884_length(amino acids)=272AA_BP=1
MAPTSSQETYSVPRGRCRRQPWPRPAHRKPTLCPGAGAGSSHGPDQLTGNLVCAPGQCRRQPWPRPAHRKPTLCPRAGAGGSRGPDQLTG
NLLCAPGQVPAAAVAPTSSQETYSVPQGRCRRQPWPRPAHRKPTLCPRAGAGPWPRPAHRKPTLCPRAGAGGSHGPDQPPPASVVLDLLQ
VQLPAGPGEDALLPDTVPITGVPAAPAGAITGHRLPRGPQVGVDRAGPEAPLAAARHGDAREAPGVTWGGQNRLHWGVILIVIFVIEGAK

--------------------------------------------------------------
>72109_72109_3_RANGAP1-FAM53A_RANGAP1_chr22_41676937_ENST00000356244_FAM53A_chr4_1643334_ENST00000489363_length(transcript)=1558nt_BP=416nt
GAACAAATCAAATCGAAGCAAAGAAACTGCCGGCTTTCAAAATCCTCCTCCTCCGCCATCATCCGCCGCGGTGCGGAGAGCAGGTGGTGC
TGGAAGCGCGTGAGGCCGGGAGCTCGAGAGAGCTAACAGACTAGCCGGCTGGACATCTGGACCGCTGGATCCGGAGGTGGCGACCCCGGC
CTGACCCGGACCCTAAATCCGTCCCCGCCCCAGAGGGCGGAGGCGCGCGCTCGATTCCCCCCACGCGGCGGCGCCGCCTGTTTACGTCTG
CAGATCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGC
CGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCA
ATTACGAAGATGACGATGAGGATGACACCCCAGTGAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGC
CTGGCTGCAGCCAGAGGGGCCTCAGGACCAGCCCTGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCA
GGAGCAGCGGGGACCCCCGTGATGGGGACAGTGTCGGGGAGGAGGGCGTCTTCCCCCGGGCCCGCTGGGAGCTGGACCTGGAGCAGATCG
AGAACAACTGAGGCTGGTGGGGGCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGT
CGGGGCCACGGCCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGG
GGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGG
TCGGGGCCACGGCTGCCACCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCTGCACTGC
CCTGGGGCACAGACTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCTGCCTGCACCTGCCCCAGGGCACAGAGTAGGTTTCCTGTGA
GCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCCGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCACCGGC
ACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGTTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCA
TGTGAGCTGGTCGGGGCCATGGCTGCTGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCGTGTTGCTTGGAACATTAAGGCGTAATTT
TGATTCAGTTTTTCCTAAAGAAGCATTTTGCATTTTTATGGCTTTTGCAGTTCGGGAGAAAGCTTCTCTATTTTGGATGCATTTCAGAAG

>72109_72109_3_RANGAP1-FAM53A_RANGAP1_chr22_41676937_ENST00000356244_FAM53A_chr4_1643334_ENST00000489363_length(amino acids)=272AA_BP=1
MAPTSSQETYSVPRGRCRRQPWPRPAHRKPTLCPGAGAGSSHGPDQLTGNLVCAPGQCRRQPWPRPAHRKPTLCPRAGAGGSRGPDQLTG
NLLCAPGQVPAAAVAPTSSQETYSVPQGRCRRQPWPRPAHRKPTLCPRAGAGPWPRPAHRKPTLCPRAGAGGSHGPDQPPPASVVLDLLQ
VQLPAGPGEDALLPDTVPITGVPAAPAGAITGHRLPRGPQVGVDRAGPEAPLAAARHGDAREAPGVTWGGQNRLHWGVILIVIFVIEGAK

--------------------------------------------------------------
>72109_72109_4_RANGAP1-FAM53A_RANGAP1_chr22_41676937_ENST00000405486_FAM53A_chr4_1643334_ENST00000461064_length(transcript)=1938nt_BP=825nt
CTTTCCCCGTCACCTGCCTGGAACAGGGGTGCGGGGCGAGGAGGGCGTGGCGCCCGTGTGCGCCTTCTGCCTGCCCCCTCGGCCTTCTTC
ACTTAGCCTTCGACGGCCGAGCGCCCCAGGGGTGGCGGTGGGAGTGGGGTTGTTGAGCGGCGCTGGCTCCTTTCACAAATGGGGAAACTG
AGGCTTAAAGGGCGTCTGACTCGCCAGAGCAGCTCAGCCTGCAGCTGCTAGCAGTGGCGTCTCATATTAGCATTGTTGTCAACCGGAGGC
GGTGCGAGTCCGCCGGGGATTCCAGATGGGGCTCCTGCGCCGCCCGCCTATCATTTGCGGCCTGTATTCGCGCGTCGCTCCCGCAGAGCC
ACCTCCCAGCAGGCCCACGCCCGCGGGGGCCCCGGGCTGGCGCCGCTGTCCCTGGAATCGATAGACGGTCTCCTTCTGTCACCCAGGCTG
GAGTGTAGTGGAACGATCACCGCTGAACTGCAGCGTCGGCTTCCTGGGCTCAAGCGATCCTCCCACCTCAACCTCCCAAGTCATGGGGAC
TACAGATGCCATCACACCTGGCTAATTTTTAAATTTTTCTGTGGAGACAGGGTCTCATTCTGTTGCCCAGGCTTGTCTCGAACCCTGGTC
TAAAGTGATCTTCCCGCCTAGCCTCCCAAAATGTTGGAATTACAGTCTGCAGATCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCT
CGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCA
ACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCAATTACGAAGATGACGATGAGGATGACACCCCAGTGAAGACG
GTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGCCTGGCTGCAGCCAGAGGGGCCTCAGGACCAGCCCTGTCCAC
CCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCAGGAGCAGCGGGGACCCCCGTGATGGGGACAGTGTCGGGGAG
GAGGGCGTCTTCCCCCGGGCCCGCTGGGAGCTGGACCTGGAGCAGATCGAGAACAACTGAGGCTGGTGGGGGCTGGTCGGGGCCATGGCT
GCCGCCTGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCCCGGCACCTGCCCTGGGGCACAGAGTAGG
TTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGC
TGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCACCGGCACCTGCCCTGGGGCACAG
AGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCCTGTGAGCTGGTCGGGGCC
ATGGCTGCTGCCTGCACCTGCCCCAGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCCGGGG
CACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCACCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGTTGGTC
GGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCATGTGAGCTGGTCGGGGCCATGGCTGCTGCCGGCACCTGCCC
TGGGGCACAGAGTAGGTTTCGTGTTGCTTGGAACATTAAGGCGTAATTTTGATTCAGTTTTTCCTAAAGAAGCATTTTGCATTTTTATGG

>72109_72109_4_RANGAP1-FAM53A_RANGAP1_chr22_41676937_ENST00000405486_FAM53A_chr4_1643334_ENST00000461064_length(amino acids)=272AA_BP=1
MAPTSSQETYSVPRGRCRRQPWPRPAHRKPTLCPGAGAGSSHGPDQLTGNLVCAPGQCRRQPWPRPAHRKPTLCPRAGAGGSRGPDQLTG
NLLCAPGQVPAAAVAPTSSQETYSVPQGRCRRQPWPRPAHRKPTLCPRAGAGPWPRPAHRKPTLCPRAGAGGSHGPDQPPPASVVLDLLQ
VQLPAGPGEDALLPDTVPITGVPAAPAGAITGHRLPRGPQVGVDRAGPEAPLAAARHGDAREAPGVTWGGQNRLHWGVILIVIFVIEGAK

--------------------------------------------------------------
>72109_72109_5_RANGAP1-FAM53A_RANGAP1_chr22_41676937_ENST00000455915_FAM53A_chr4_1643334_ENST00000308132_length(transcript)=3309nt_BP=1582nt
CCCTGTCTCTACTAAAAATACAAAAAAATTAGCTGGACATGGTGGTGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAA
TGACATGAACCTTGGAGGCGGAGCTTGCAGTGAGCCCAGATGGCGCCACTGTGCTCCAGCCTGGGCGACTGAGCGAGACTCCGTCTCAAA
AAAAAAAAATTCTTTCATTTATTTAGTTACTTTTAGAGATAGAGCCTCCCGCTGTTGCCCAGGCTGGAGTGCAGTGGCAGTCATAGCTTA
CTGCAGCTTTGAACTCCTGGGCTCAAATGATCCTCCTGCCTCAGCCTCTCCAGTAGCTGGGACTGACTACAGGCACGTGCCACCACACCC
AGCTAATTTTTATTTTTATTTTTATTTTTTTGAGACAGGGTTTTACTCTGTCACCCAGGCTAGAGTGCAGTGGTGAGATCATGGCTCACT
GTAGCCTCTGTCTCCGGGGCTCAATCAATCCTCCCACCTCAGCCTCCCCAGTGGCTGGGATTACTGGTGCACACCACCATACCCTGCTAA
TTGTATTTATTTTTAGTAGAGATGGGATTTTGCCATGTTGCCCAGACTGGTCTTGAGCTGCTGGGCTCAAGCGATCTTCCCATCACAGCT
TCCCAATGTGCTGGGATTACAGGTGTGAGCCACTGTACCTGGCCAGCTTTACTTCTTTTACCAGCACTCCTGATTTTATAAATAGTGAGG
CTTATCAACCCCATTTCTACCCAAATCTTCTGGTAGACTTGAGTATAGTAGGGCTTCATAGGTAGCAGCCCTGTCCCTGTCCTATTATGA
TGGTAGCTGTTGTGATGTGGCGATCTCTGATCTAGAAACCCCTGAGGGGCCATTGTGGCCTGCCCAGTCTCCCGGCCACGGTTGAAACCA
GACGTGCAGTGGGGCTGACCCCTGTGCCCCACCCCAGAGTCATGCCAGCGTGGGTGGTGGGGCATTCTCTGGGATGAATGATCTGGATCC
CATAGCCATCTGTGTCCTGTTTGAGGAATGGGACCCTCAAACAGAGAACAGCCAAGATGCTCAAGCAGGTGTGTGCTTGGGCCAGACTCT
GCAGCCTTTGGTTTGGGACTTGACTGCCATTCACTGAAGGGGCCCAGGAAATGGGCAGCTCACATGGTGTTGCTGGGTGTCCAGCTGCGG
CAGTTTAGCAGAGGAGGACTTGTAATGAGATGGTAGCTTCTTATAGGCTAAGACATGATTTTTCTGTTCTTTTACTACCTCCTGCACCTT
CTAGAACTGTTCCTTCTCTGATGCTGTTTTCCTTTCTTCCAGTGATTTATCTCTAGGGTCTCCATAGCAGGGGAGGTAGGGTCAGACTCC
TGAGATGGCTGATGTCCTACCCTGCCCCCAACCAGGGGCCCCAGGAGACTCCTTTTTCTTACTGCAACTTTGGCCTCCTCAGTCTGCAGA
TCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGG
GGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCAATTA
CGAAGATGACGATGAGGATGACACCCCAGTGAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGCCTGG
CTGCAGCCAGAGGGGCCTCAGGACCAGCCCTGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCAGGAG
CAGCGGGGACCCCCGTGATGGGGACAGTGTCGGGGAGGAGGGCGTCTTCCCCCGGGCCCGCTGGGAGCTGGACCTGGAGCAGATCGAGAA
CAACTGAGGCTGGTGGGGGCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGG
GCCACGGCCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCA
CAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGG
GGCCACGGCTGCCACCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTG
GGGCACAGACTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCTGCCTGCACCTGCCCCAGGGCACAGAGTAGGTTTCCTGTGAGCTG
GTCGGGGCCATGGCTGCCGCCTGCACCTGCCCCGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCACCGGCACCT
GCCCTGGGGCACAGAGTAGGTTTCCTGTGAGTTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCATGTG
AGCTGGTCGGGGCCATGGCTGCTGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCGTGTTGCTTGGAACATTAAGGCGTAATTTTGAT
TCAGTTTTTCCTAAAGAAGCATTTTGCATTTTTATGGCTTTTGCAGTTCGGGAGAAAGCTTCTCTATTTTGGATGCATTTCAGAAGGGCG
TTCTATTAAACATGAATCTGCAAACAGATTAACATGCGTCTGTGTTCCCCACGAAAGGCCTGCTGTGCAGGGCGCCTTGTGTGCTTTAGT
TGCTAGGAAACCCCGGGCGTTGGTGGTCAGAGTCCCACTGGCCCCGTGTGTCCCCCCCTCCCGACGGGTCACGGTGCTTGGGGCTTGCGC
ATGGGCATCTGTGCCCATGAACCTTGTCACCCACGTGCCAGTGAACCGCCAGCTTGTGGCCGCCTGGTTTTCCACCGGTGGCAGTGATGG
CCTTTGGGGCAGACCAAGGTGCCATGAGTCCCTGCTTCCCGTGGCCTGGGAGGGCCCTTGCACCTTCAGGTGGGGTGTAGTGCCAGACCT
CTGGGAAGGCTGTCCTGCCGGCAGCACCCGTCAGCACCCACTCTGTGAATTTAATACAAGGCCTTTGCTTTGTGCATACGACTTCTGATT
AATTTTCGTTTCCACCATCTGAAGTGGGCCTGGCTGCGCCTCAGGCCTCTGGTCTCTGGCTCAGAACCAGACAAGGCAAGGGATTTCCTG

>72109_72109_5_RANGAP1-FAM53A_RANGAP1_chr22_41676937_ENST00000455915_FAM53A_chr4_1643334_ENST00000308132_length(amino acids)=272AA_BP=1
MAPTSSQETYSVPRGRCRRQPWPRPAHRKPTLCPGAGAGSSHGPDQLTGNLVCAPGQCRRQPWPRPAHRKPTLCPRAGAGGSRGPDQLTG
NLLCAPGQVPAAAVAPTSSQETYSVPQGRCRRQPWPRPAHRKPTLCPRAGAGPWPRPAHRKPTLCPRAGAGGSHGPDQPPPASVVLDLLQ
VQLPAGPGEDALLPDTVPITGVPAAPAGAITGHRLPRGPQVGVDRAGPEAPLAAARHGDAREAPGVTWGGQNRLHWGVILIVIFVIEGAK

--------------------------------------------------------------
>72109_72109_6_RANGAP1-FAM53A_RANGAP1_chr22_41676937_ENST00000455915_FAM53A_chr4_1643334_ENST00000472884_length(transcript)=2588nt_BP=1582nt
CCCTGTCTCTACTAAAAATACAAAAAAATTAGCTGGACATGGTGGTGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAA
TGACATGAACCTTGGAGGCGGAGCTTGCAGTGAGCCCAGATGGCGCCACTGTGCTCCAGCCTGGGCGACTGAGCGAGACTCCGTCTCAAA
AAAAAAAAATTCTTTCATTTATTTAGTTACTTTTAGAGATAGAGCCTCCCGCTGTTGCCCAGGCTGGAGTGCAGTGGCAGTCATAGCTTA
CTGCAGCTTTGAACTCCTGGGCTCAAATGATCCTCCTGCCTCAGCCTCTCCAGTAGCTGGGACTGACTACAGGCACGTGCCACCACACCC
AGCTAATTTTTATTTTTATTTTTATTTTTTTGAGACAGGGTTTTACTCTGTCACCCAGGCTAGAGTGCAGTGGTGAGATCATGGCTCACT
GTAGCCTCTGTCTCCGGGGCTCAATCAATCCTCCCACCTCAGCCTCCCCAGTGGCTGGGATTACTGGTGCACACCACCATACCCTGCTAA
TTGTATTTATTTTTAGTAGAGATGGGATTTTGCCATGTTGCCCAGACTGGTCTTGAGCTGCTGGGCTCAAGCGATCTTCCCATCACAGCT
TCCCAATGTGCTGGGATTACAGGTGTGAGCCACTGTACCTGGCCAGCTTTACTTCTTTTACCAGCACTCCTGATTTTATAAATAGTGAGG
CTTATCAACCCCATTTCTACCCAAATCTTCTGGTAGACTTGAGTATAGTAGGGCTTCATAGGTAGCAGCCCTGTCCCTGTCCTATTATGA
TGGTAGCTGTTGTGATGTGGCGATCTCTGATCTAGAAACCCCTGAGGGGCCATTGTGGCCTGCCCAGTCTCCCGGCCACGGTTGAAACCA
GACGTGCAGTGGGGCTGACCCCTGTGCCCCACCCCAGAGTCATGCCAGCGTGGGTGGTGGGGCATTCTCTGGGATGAATGATCTGGATCC
CATAGCCATCTGTGTCCTGTTTGAGGAATGGGACCCTCAAACAGAGAACAGCCAAGATGCTCAAGCAGGTGTGTGCTTGGGCCAGACTCT
GCAGCCTTTGGTTTGGGACTTGACTGCCATTCACTGAAGGGGCCCAGGAAATGGGCAGCTCACATGGTGTTGCTGGGTGTCCAGCTGCGG
CAGTTTAGCAGAGGAGGACTTGTAATGAGATGGTAGCTTCTTATAGGCTAAGACATGATTTTTCTGTTCTTTTACTACCTCCTGCACCTT
CTAGAACTGTTCCTTCTCTGATGCTGTTTTCCTTTCTTCCAGTGATTTATCTCTAGGGTCTCCATAGCAGGGGAGGTAGGGTCAGACTCC
TGAGATGGCTGATGTCCTACCCTGCCCCCAACCAGGGGCCCCAGGAGACTCCTTTTTCTTACTGCAACTTTGGCCTCCTCAGTCTGCAGA
TCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGG
GGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCAATTA
CGAAGATGACGATGAGGATGACACCCCAGTGAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGCCTGG
CTGCAGCCAGAGGGGCCTCAGGACCAGCCCTGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCAGGAG
CAGCGGGGACCCCCGTGATGGGGACAGTGTCGGGGAGGAGGGCGTCTTCCCCCGGGCCCGCTGGGAGCTGGACCTGGAGCAGATCGAGAA
CAACTGAGGCTGGTGGGGGCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGG
GCCACGGCCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCA
CAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGG
GGCCACGGCTGCCACCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTG
GGGCACAGACTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCTGCCTGCACCTGCCCCAGGGCACAGAGTAGGTTTCCTGTGAGCTG
GTCGGGGCCATGGCTGCCGCCTGCACCTGCCCCGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCACCGGCACCT
GCCCTGGGGCACAGAGTAGGTTTCCTGTGAGTTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCATGTG

>72109_72109_6_RANGAP1-FAM53A_RANGAP1_chr22_41676937_ENST00000455915_FAM53A_chr4_1643334_ENST00000472884_length(amino acids)=272AA_BP=1
MAPTSSQETYSVPRGRCRRQPWPRPAHRKPTLCPGAGAGSSHGPDQLTGNLVCAPGQCRRQPWPRPAHRKPTLCPRAGAGGSRGPDQLTG
NLLCAPGQVPAAAVAPTSSQETYSVPQGRCRRQPWPRPAHRKPTLCPRAGAGPWPRPAHRKPTLCPRAGAGGSHGPDQPPPASVVLDLLQ
VQLPAGPGEDALLPDTVPITGVPAAPAGAITGHRLPRGPQVGVDRAGPEAPLAAARHGDAREAPGVTWGGQNRLHWGVILIVIFVIEGAK

--------------------------------------------------------------
>72109_72109_7_RANGAP1-FAM53A_RANGAP1_chr22_41676937_ENST00000455915_FAM53A_chr4_1643334_ENST00000489363_length(transcript)=2724nt_BP=1582nt
CCCTGTCTCTACTAAAAATACAAAAAAATTAGCTGGACATGGTGGTGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAA
TGACATGAACCTTGGAGGCGGAGCTTGCAGTGAGCCCAGATGGCGCCACTGTGCTCCAGCCTGGGCGACTGAGCGAGACTCCGTCTCAAA
AAAAAAAAATTCTTTCATTTATTTAGTTACTTTTAGAGATAGAGCCTCCCGCTGTTGCCCAGGCTGGAGTGCAGTGGCAGTCATAGCTTA
CTGCAGCTTTGAACTCCTGGGCTCAAATGATCCTCCTGCCTCAGCCTCTCCAGTAGCTGGGACTGACTACAGGCACGTGCCACCACACCC
AGCTAATTTTTATTTTTATTTTTATTTTTTTGAGACAGGGTTTTACTCTGTCACCCAGGCTAGAGTGCAGTGGTGAGATCATGGCTCACT
GTAGCCTCTGTCTCCGGGGCTCAATCAATCCTCCCACCTCAGCCTCCCCAGTGGCTGGGATTACTGGTGCACACCACCATACCCTGCTAA
TTGTATTTATTTTTAGTAGAGATGGGATTTTGCCATGTTGCCCAGACTGGTCTTGAGCTGCTGGGCTCAAGCGATCTTCCCATCACAGCT
TCCCAATGTGCTGGGATTACAGGTGTGAGCCACTGTACCTGGCCAGCTTTACTTCTTTTACCAGCACTCCTGATTTTATAAATAGTGAGG
CTTATCAACCCCATTTCTACCCAAATCTTCTGGTAGACTTGAGTATAGTAGGGCTTCATAGGTAGCAGCCCTGTCCCTGTCCTATTATGA
TGGTAGCTGTTGTGATGTGGCGATCTCTGATCTAGAAACCCCTGAGGGGCCATTGTGGCCTGCCCAGTCTCCCGGCCACGGTTGAAACCA
GACGTGCAGTGGGGCTGACCCCTGTGCCCCACCCCAGAGTCATGCCAGCGTGGGTGGTGGGGCATTCTCTGGGATGAATGATCTGGATCC
CATAGCCATCTGTGTCCTGTTTGAGGAATGGGACCCTCAAACAGAGAACAGCCAAGATGCTCAAGCAGGTGTGTGCTTGGGCCAGACTCT
GCAGCCTTTGGTTTGGGACTTGACTGCCATTCACTGAAGGGGCCCAGGAAATGGGCAGCTCACATGGTGTTGCTGGGTGTCCAGCTGCGG
CAGTTTAGCAGAGGAGGACTTGTAATGAGATGGTAGCTTCTTATAGGCTAAGACATGATTTTTCTGTTCTTTTACTACCTCCTGCACCTT
CTAGAACTGTTCCTTCTCTGATGCTGTTTTCCTTTCTTCCAGTGATTTATCTCTAGGGTCTCCATAGCAGGGGAGGTAGGGTCAGACTCC
TGAGATGGCTGATGTCCTACCCTGCCCCCAACCAGGGGCCCCAGGAGACTCCTTTTTCTTACTGCAACTTTGGCCTCCTCAGTCTGCAGA
TCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGG
GGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCAATTA
CGAAGATGACGATGAGGATGACACCCCAGTGAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGCCTGG
CTGCAGCCAGAGGGGCCTCAGGACCAGCCCTGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCAGGAG
CAGCGGGGACCCCCGTGATGGGGACAGTGTCGGGGAGGAGGGCGTCTTCCCCCGGGCCCGCTGGGAGCTGGACCTGGAGCAGATCGAGAA
CAACTGAGGCTGGTGGGGGCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGG
GCCACGGCCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCA
CAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGG
GGCCACGGCTGCCACCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTG
GGGCACAGACTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCTGCCTGCACCTGCCCCAGGGCACAGAGTAGGTTTCCTGTGAGCTG
GTCGGGGCCATGGCTGCCGCCTGCACCTGCCCCGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCACCGGCACCT
GCCCTGGGGCACAGAGTAGGTTTCCTGTGAGTTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCATGTG
AGCTGGTCGGGGCCATGGCTGCTGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCGTGTTGCTTGGAACATTAAGGCGTAATTTTGAT
TCAGTTTTTCCTAAAGAAGCATTTTGCATTTTTATGGCTTTTGCAGTTCGGGAGAAAGCTTCTCTATTTTGGATGCATTTCAGAAGGGCG

>72109_72109_7_RANGAP1-FAM53A_RANGAP1_chr22_41676937_ENST00000455915_FAM53A_chr4_1643334_ENST00000489363_length(amino acids)=272AA_BP=1
MAPTSSQETYSVPRGRCRRQPWPRPAHRKPTLCPGAGAGSSHGPDQLTGNLVCAPGQCRRQPWPRPAHRKPTLCPRAGAGGSRGPDQLTG
NLLCAPGQVPAAAVAPTSSQETYSVPQGRCRRQPWPRPAHRKPTLCPRAGAGPWPRPAHRKPTLCPRAGAGGSHGPDQPPPASVVLDLLQ
VQLPAGPGEDALLPDTVPITGVPAAPAGAITGHRLPRGPQVGVDRAGPEAPLAAARHGDAREAPGVTWGGQNRLHWGVILIVIFVIEGAK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RANGAP1-FAM53A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RANGAP1-FAM53A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for RANGAP1-FAM53A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source