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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RANGAP1-PMM1 (FusionGDB2 ID:72115)

Fusion Gene Summary for RANGAP1-PMM1

check button Fusion gene summary
Fusion gene informationFusion gene name: RANGAP1-PMM1
Fusion gene ID: 72115
HgeneTgene
Gene symbol

RANGAP1

PMM1

Gene ID

5905

5372

Gene nameRan GTPase activating protein 1phosphomannomutase 1
SynonymsFug1|RANGAP|SDPMM 1|PMMH-22|Sec53
Cytomap

22q13.2

22q13.2

Type of geneprotein-codingprotein-coding
Descriptionran GTPase-activating protein 1segregation distorter homologsegregation distortionphosphomannomutase 1brain glucose-1,6-bisphosphatase
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000356244, ENST00000405486, 
ENST00000407260, ENST00000455915, 
ENST00000466645, ENST00000216259, 
Fusion gene scores* DoF score16 X 14 X 7=15682 X 2 X 2=8
# samples 183
** MAII scorelog2(18/1568*10)=-3.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: RANGAP1 [Title/Abstract] AND PMM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRANGAP1(41664101)-PMM1(41974885), # samples:2
Anticipated loss of major functional domain due to fusion event.RANGAP1-PMM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RANGAP1-PMM1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRANGAP1

GO:0046826

negative regulation of protein export from nucleus

16449645

HgeneRANGAP1

GO:0090630

activation of GTPase activity

16428860

TgenePMM1

GO:0006013

mannose metabolic process

16540464


check buttonFusion gene breakpoints across RANGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PMM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2280-01ARANGAP1chr22

41664101

-PMM1chr22

41974885

-
ChimerDB4OVTCGA-24-2280RANGAP1chr22

41664100

-PMM1chr22

41974885

-


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Fusion Gene ORF analysis for RANGAP1-PMM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356244ENST00000466645RANGAP1chr22

41664101

-PMM1chr22

41974885

-
5CDS-intronENST00000356244ENST00000466645RANGAP1chr22

41664100

-PMM1chr22

41974885

-
5CDS-intronENST00000405486ENST00000466645RANGAP1chr22

41664101

-PMM1chr22

41974885

-
5CDS-intronENST00000405486ENST00000466645RANGAP1chr22

41664100

-PMM1chr22

41974885

-
5CDS-intronENST00000407260ENST00000466645RANGAP1chr22

41664101

-PMM1chr22

41974885

-
5CDS-intronENST00000407260ENST00000466645RANGAP1chr22

41664100

-PMM1chr22

41974885

-
5CDS-intronENST00000455915ENST00000466645RANGAP1chr22

41664101

-PMM1chr22

41974885

-
5CDS-intronENST00000455915ENST00000466645RANGAP1chr22

41664100

-PMM1chr22

41974885

-
Frame-shiftENST00000356244ENST00000216259RANGAP1chr22

41664101

-PMM1chr22

41974885

-
Frame-shiftENST00000356244ENST00000216259RANGAP1chr22

41664100

-PMM1chr22

41974885

-
Frame-shiftENST00000405486ENST00000216259RANGAP1chr22

41664101

-PMM1chr22

41974885

-
Frame-shiftENST00000405486ENST00000216259RANGAP1chr22

41664100

-PMM1chr22

41974885

-
In-frameENST00000407260ENST00000216259RANGAP1chr22

41664101

-PMM1chr22

41974885

-
In-frameENST00000407260ENST00000216259RANGAP1chr22

41664100

-PMM1chr22

41974885

-
In-frameENST00000455915ENST00000216259RANGAP1chr22

41664101

-PMM1chr22

41974885

-
In-frameENST00000455915ENST00000216259RANGAP1chr22

41664100

-PMM1chr22

41974885

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000455915RANGAP1chr2241664101-ENST00000216259PMM1chr2241974885-2509177013712084237
ENST00000407260RANGAP1chr2241664101-ENST00000216259PMM1chr2241974885-1042303884219221
ENST00000455915RANGAP1chr2241664100-ENST00000216259PMM1chr2241974885-2509177013712084237
ENST00000407260RANGAP1chr2241664100-ENST00000216259PMM1chr2241974885-1042303884219221

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000455915ENST00000216259RANGAP1chr2241664101-PMM1chr2241974885-0.0040504970.9959495
ENST00000407260ENST00000216259RANGAP1chr2241664101-PMM1chr2241974885-0.0027721140.99722785
ENST00000455915ENST00000216259RANGAP1chr2241664100-PMM1chr2241974885-0.0040504970.9959495
ENST00000407260ENST00000216259RANGAP1chr2241664100-PMM1chr2241974885-0.0027721140.99722785

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Fusion Genomic Features for RANGAP1-PMM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RANGAP1-PMM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:41664101/chr22:41974885)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000356244-41648_71100588.0RepeatNote=LRR 1
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000405486-51748_71100588.0RepeatNote=LRR 1
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000455915-31548_71100588.0RepeatNote=LRR 1
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000356244-41648_71100588.0RepeatNote=LRR 1
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000405486-51748_71100588.0RepeatNote=LRR 1
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000455915-31548_71100588.0RepeatNote=LRR 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000356244-416359_397100588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000356244-416359_399100588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000405486-517359_397100588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000405486-517359_399100588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000455915-315359_397100588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000455915-315359_399100588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000356244-416359_397100588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000356244-416359_399100588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000405486-517359_397100588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000405486-517359_399100588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000455915-315359_397100588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000455915-315359_399100588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000356244-416523_526100588.0MotifNote=SUMO conjugation
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000405486-517523_526100588.0MotifNote=SUMO conjugation
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000455915-315523_526100588.0MotifNote=SUMO conjugation
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000356244-416523_526100588.0MotifNote=SUMO conjugation
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000405486-517523_526100588.0MotifNote=SUMO conjugation
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000455915-315523_526100588.0MotifNote=SUMO conjugation
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000356244-416111_134100588.0RepeatNote=LRR 2
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000356244-416207_230100588.0RepeatNote=LRR 3
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000356244-416235_258100588.0RepeatNote=LRR 4
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000356244-416292_319100588.0RepeatNote=LRR 5
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000356244-416320_343100588.0RepeatNote=LRR 6
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000405486-517111_134100588.0RepeatNote=LRR 2
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000405486-517207_230100588.0RepeatNote=LRR 3
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000405486-517235_258100588.0RepeatNote=LRR 4
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000405486-517292_319100588.0RepeatNote=LRR 5
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000405486-517320_343100588.0RepeatNote=LRR 6
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000455915-315111_134100588.0RepeatNote=LRR 2
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000455915-315207_230100588.0RepeatNote=LRR 3
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000455915-315235_258100588.0RepeatNote=LRR 4
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000455915-315292_319100588.0RepeatNote=LRR 5
HgeneRANGAP1chr22:41664100chr22:41974885ENST00000455915-315320_343100588.0RepeatNote=LRR 6
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000356244-416111_134100588.0RepeatNote=LRR 2
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000356244-416207_230100588.0RepeatNote=LRR 3
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000356244-416235_258100588.0RepeatNote=LRR 4
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000356244-416292_319100588.0RepeatNote=LRR 5
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000356244-416320_343100588.0RepeatNote=LRR 6
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000405486-517111_134100588.0RepeatNote=LRR 2
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000405486-517207_230100588.0RepeatNote=LRR 3
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000405486-517235_258100588.0RepeatNote=LRR 4
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000405486-517292_319100588.0RepeatNote=LRR 5
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000405486-517320_343100588.0RepeatNote=LRR 6
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000455915-315111_134100588.0RepeatNote=LRR 2
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000455915-315207_230100588.0RepeatNote=LRR 3
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000455915-315235_258100588.0RepeatNote=LRR 4
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000455915-315292_319100588.0RepeatNote=LRR 5
HgeneRANGAP1chr22:41664101chr22:41974885ENST00000455915-315320_343100588.0RepeatNote=LRR 6


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Fusion Gene Sequence for RANGAP1-PMM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72115_72115_1_RANGAP1-PMM1_RANGAP1_chr22_41664100_ENST00000407260_PMM1_chr22_41974885_ENST00000216259_length(transcript)=1042nt_BP=303nt
ATTTGCCCAGGAGCAAGCTCCCCTGCACTTTCCATGTTTGTATTGGGCATCCCTTTGTGCCCTGCCCTTTCTTTCTCAGGAGGGGATGAT
AGCCAGACTCAACTTTTTGTTTCATCTAAAGATGTGATTAAAGAGATTGAAGACTTTGACAGCTTGGAGGCTCTGCGTCTGGAAGGCAAC
ACAGTGGGCGTGGAAGCAGCCAGGGTCATCGCCAAGGCCTTAGAGAAGAAGTCGGAGTTGAAGCGCTGCCACTGGAGTGACATGTTCACG
GGAAGGCTGCGGACCGAGATCCCACCAGCCCTGAAAGAGAAGATCCGGGAGAAGTTCGTGGAAGCCCTGAAAACAGAGTTTGCTGGCAAA
GGGCTGAGGTTCTCTCGAGGAGGCATGATCAGCTTTGACGTCTTCCCCGAGGGCTGGGACAAGCGCTACTGCCTGGATAGCCTGGACCAG
GACAGCTTCGACACCATCCACTTCTTTGGGAACGAGACTAGCCCTGGTGGGAACGACTTTGAGATCTTTGCCGACCCCCGGACTGTTGGC
CACAGCGTGGTGTCTCCTCAGGACACGGTGCAGCGATGCCGGGAGATTTTCTTCCCAGAGACAGCTCATGAGGCGTGACCGGGGCCCACA
TCTGTGTGTCGTGACTTCTGAAGAGTTTGGCCTAGGCCTAAAGAGAGGTCCTGGTGTTGGATAGATGCCAGGGCCCCTCCTCTGGCCCAG
GACGCCTGCTGCAAGCCCACCCAGATGGGGCCAGAGTCTGTGTGGACAACCGTCCCCAGCCAGTCTGCTCCTAGTGGCACTGGCTTCGTC
CTCCCAGGGCCCAGAGTGTTCCCCATGCTCCACCTGGTGGCCCAGGCCACAGCTGCTGCTTGTATTTCGGTACAGAAGAGGTTTCTTTCT
GCACCAGGAGGAGGCGTGCTCAAGTATCGGTACGAGATCTAGCCTGCCCTGCCTGCCTGCCCTGGGCGATGAGGTACGGTGGGGAAGGTG

>72115_72115_1_RANGAP1-PMM1_RANGAP1_chr22_41664100_ENST00000407260_PMM1_chr22_41974885_ENST00000216259_length(amino acids)=221AA_BP=1
MYRNTSSSCGLGHQVEHGEHSGPWEDEASATRSRLAGDGCPHRLWPHLGGLAAGVLGQRRGPGIYPTPGPLFRPRPNSSEVTTHRCGPRS
RLMSCLWEENLPASLHRVLRRHHAVANSPGVGKDLKVVPTRASLVPKEVDGVEAVLVQAIQAVALVPALGEDVKADHASSREPQPFASKL

--------------------------------------------------------------
>72115_72115_2_RANGAP1-PMM1_RANGAP1_chr22_41664100_ENST00000455915_PMM1_chr22_41974885_ENST00000216259_length(transcript)=2509nt_BP=1770nt
CCCTGTCTCTACTAAAAATACAAAAAAATTAGCTGGACATGGTGGTGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAA
TGACATGAACCTTGGAGGCGGAGCTTGCAGTGAGCCCAGATGGCGCCACTGTGCTCCAGCCTGGGCGACTGAGCGAGACTCCGTCTCAAA
AAAAAAAAATTCTTTCATTTATTTAGTTACTTTTAGAGATAGAGCCTCCCGCTGTTGCCCAGGCTGGAGTGCAGTGGCAGTCATAGCTTA
CTGCAGCTTTGAACTCCTGGGCTCAAATGATCCTCCTGCCTCAGCCTCTCCAGTAGCTGGGACTGACTACAGGCACGTGCCACCACACCC
AGCTAATTTTTATTTTTATTTTTATTTTTTTGAGACAGGGTTTTACTCTGTCACCCAGGCTAGAGTGCAGTGGTGAGATCATGGCTCACT
GTAGCCTCTGTCTCCGGGGCTCAATCAATCCTCCCACCTCAGCCTCCCCAGTGGCTGGGATTACTGGTGCACACCACCATACCCTGCTAA
TTGTATTTATTTTTAGTAGAGATGGGATTTTGCCATGTTGCCCAGACTGGTCTTGAGCTGCTGGGCTCAAGCGATCTTCCCATCACAGCT
TCCCAATGTGCTGGGATTACAGGTGTGAGCCACTGTACCTGGCCAGCTTTACTTCTTTTACCAGCACTCCTGATTTTATAAATAGTGAGG
CTTATCAACCCCATTTCTACCCAAATCTTCTGGTAGACTTGAGTATAGTAGGGCTTCATAGGTAGCAGCCCTGTCCCTGTCCTATTATGA
TGGTAGCTGTTGTGATGTGGCGATCTCTGATCTAGAAACCCCTGAGGGGCCATTGTGGCCTGCCCAGTCTCCCGGCCACGGTTGAAACCA
GACGTGCAGTGGGGCTGACCCCTGTGCCCCACCCCAGAGTCATGCCAGCGTGGGTGGTGGGGCATTCTCTGGGATGAATGATCTGGATCC
CATAGCCATCTGTGTCCTGTTTGAGGAATGGGACCCTCAAACAGAGAACAGCCAAGATGCTCAAGCAGGTGTGTGCTTGGGCCAGACTCT
GCAGCCTTTGGTTTGGGACTTGACTGCCATTCACTGAAGGGGCCCAGGAAATGGGCAGCTCACATGGTGTTGCTGGGTGTCCAGCTGCGG
CAGTTTAGCAGAGGAGGACTTGTAATGAGATGGTAGCTTCTTATAGGCTAAGACATGATTTTTCTGTTCTTTTACTACCTCCTGCACCTT
CTAGAACTGTTCCTTCTCTGATGCTGTTTTCCTTTCTTCCAGTGATTTATCTCTAGGGTCTCCATAGCAGGGGAGGTAGGGTCAGACTCC
TGAGATGGCTGATGTCCTACCCTGCCCCCAACCAGGGGCCCCAGGAGACTCCTTTTTCTTACTGCAACTTTGGCCTCCTCAGTCTGCAGA
TCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGG
GGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCAACACTGCAGAAGATGCTAAAGATGTGATTAAAGAGATTGAAGACTTTGACAGC
TTGGAGGCTCTGCGTCTGGAAGGCAACACAGTGGGCGTGGAAGCAGCCAGGGTCATCGCCAAGGCCTTAGAGAAGAAGTCGGAGTTGAAG
CGCTGCCACTGGAGTGACATGTTCACGGGAAGGCTGCGGACCGAGATCCCACCAGCCCTGAAAGAGAAGATCCGGGAGAAGTTCGTGGAA
GCCCTGAAAACAGAGTTTGCTGGCAAAGGGCTGAGGTTCTCTCGAGGAGGCATGATCAGCTTTGACGTCTTCCCCGAGGGCTGGGACAAG
CGCTACTGCCTGGATAGCCTGGACCAGGACAGCTTCGACACCATCCACTTCTTTGGGAACGAGACTAGCCCTGGTGGGAACGACTTTGAG
ATCTTTGCCGACCCCCGGACTGTTGGCCACAGCGTGGTGTCTCCTCAGGACACGGTGCAGCGATGCCGGGAGATTTTCTTCCCAGAGACA
GCTCATGAGGCGTGACCGGGGCCCACATCTGTGTGTCGTGACTTCTGAAGAGTTTGGCCTAGGCCTAAAGAGAGGTCCTGGTGTTGGATA
GATGCCAGGGCCCCTCCTCTGGCCCAGGACGCCTGCTGCAAGCCCACCCAGATGGGGCCAGAGTCTGTGTGGACAACCGTCCCCAGCCAG
TCTGCTCCTAGTGGCACTGGCTTCGTCCTCCCAGGGCCCAGAGTGTTCCCCATGCTCCACCTGGTGGCCCAGGCCACAGCTGCTGCTTGT
ATTTCGGTACAGAAGAGGTTTCTTTCTGCACCAGGAGGAGGCGTGCTCAAGTATCGGTACGAGATCTAGCCTGCCCTGCCTGCCTGCCCT

>72115_72115_2_RANGAP1-PMM1_RANGAP1_chr22_41664100_ENST00000455915_PMM1_chr22_41974885_ENST00000216259_length(amino acids)=237AA_BP=133
MPPTRGPRRLLFLTATLASSVCRSPGEPTSLVNMASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDAKDVIKEIEDFDSLEALRLE
GNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALKEKIREKFVEALKTEFAGKGLRFSRGGMISFDVFPEGWDKRYCLDSL

--------------------------------------------------------------
>72115_72115_3_RANGAP1-PMM1_RANGAP1_chr22_41664101_ENST00000407260_PMM1_chr22_41974885_ENST00000216259_length(transcript)=1042nt_BP=303nt
ATTTGCCCAGGAGCAAGCTCCCCTGCACTTTCCATGTTTGTATTGGGCATCCCTTTGTGCCCTGCCCTTTCTTTCTCAGGAGGGGATGAT
AGCCAGACTCAACTTTTTGTTTCATCTAAAGATGTGATTAAAGAGATTGAAGACTTTGACAGCTTGGAGGCTCTGCGTCTGGAAGGCAAC
ACAGTGGGCGTGGAAGCAGCCAGGGTCATCGCCAAGGCCTTAGAGAAGAAGTCGGAGTTGAAGCGCTGCCACTGGAGTGACATGTTCACG
GGAAGGCTGCGGACCGAGATCCCACCAGCCCTGAAAGAGAAGATCCGGGAGAAGTTCGTGGAAGCCCTGAAAACAGAGTTTGCTGGCAAA
GGGCTGAGGTTCTCTCGAGGAGGCATGATCAGCTTTGACGTCTTCCCCGAGGGCTGGGACAAGCGCTACTGCCTGGATAGCCTGGACCAG
GACAGCTTCGACACCATCCACTTCTTTGGGAACGAGACTAGCCCTGGTGGGAACGACTTTGAGATCTTTGCCGACCCCCGGACTGTTGGC
CACAGCGTGGTGTCTCCTCAGGACACGGTGCAGCGATGCCGGGAGATTTTCTTCCCAGAGACAGCTCATGAGGCGTGACCGGGGCCCACA
TCTGTGTGTCGTGACTTCTGAAGAGTTTGGCCTAGGCCTAAAGAGAGGTCCTGGTGTTGGATAGATGCCAGGGCCCCTCCTCTGGCCCAG
GACGCCTGCTGCAAGCCCACCCAGATGGGGCCAGAGTCTGTGTGGACAACCGTCCCCAGCCAGTCTGCTCCTAGTGGCACTGGCTTCGTC
CTCCCAGGGCCCAGAGTGTTCCCCATGCTCCACCTGGTGGCCCAGGCCACAGCTGCTGCTTGTATTTCGGTACAGAAGAGGTTTCTTTCT
GCACCAGGAGGAGGCGTGCTCAAGTATCGGTACGAGATCTAGCCTGCCCTGCCTGCCTGCCCTGGGCGATGAGGTACGGTGGGGAAGGTG

>72115_72115_3_RANGAP1-PMM1_RANGAP1_chr22_41664101_ENST00000407260_PMM1_chr22_41974885_ENST00000216259_length(amino acids)=221AA_BP=1
MYRNTSSSCGLGHQVEHGEHSGPWEDEASATRSRLAGDGCPHRLWPHLGGLAAGVLGQRRGPGIYPTPGPLFRPRPNSSEVTTHRCGPRS
RLMSCLWEENLPASLHRVLRRHHAVANSPGVGKDLKVVPTRASLVPKEVDGVEAVLVQAIQAVALVPALGEDVKADHASSREPQPFASKL

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>72115_72115_4_RANGAP1-PMM1_RANGAP1_chr22_41664101_ENST00000455915_PMM1_chr22_41974885_ENST00000216259_length(transcript)=2509nt_BP=1770nt
CCCTGTCTCTACTAAAAATACAAAAAAATTAGCTGGACATGGTGGTGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAA
TGACATGAACCTTGGAGGCGGAGCTTGCAGTGAGCCCAGATGGCGCCACTGTGCTCCAGCCTGGGCGACTGAGCGAGACTCCGTCTCAAA
AAAAAAAAATTCTTTCATTTATTTAGTTACTTTTAGAGATAGAGCCTCCCGCTGTTGCCCAGGCTGGAGTGCAGTGGCAGTCATAGCTTA
CTGCAGCTTTGAACTCCTGGGCTCAAATGATCCTCCTGCCTCAGCCTCTCCAGTAGCTGGGACTGACTACAGGCACGTGCCACCACACCC
AGCTAATTTTTATTTTTATTTTTATTTTTTTGAGACAGGGTTTTACTCTGTCACCCAGGCTAGAGTGCAGTGGTGAGATCATGGCTCACT
GTAGCCTCTGTCTCCGGGGCTCAATCAATCCTCCCACCTCAGCCTCCCCAGTGGCTGGGATTACTGGTGCACACCACCATACCCTGCTAA
TTGTATTTATTTTTAGTAGAGATGGGATTTTGCCATGTTGCCCAGACTGGTCTTGAGCTGCTGGGCTCAAGCGATCTTCCCATCACAGCT
TCCCAATGTGCTGGGATTACAGGTGTGAGCCACTGTACCTGGCCAGCTTTACTTCTTTTACCAGCACTCCTGATTTTATAAATAGTGAGG
CTTATCAACCCCATTTCTACCCAAATCTTCTGGTAGACTTGAGTATAGTAGGGCTTCATAGGTAGCAGCCCTGTCCCTGTCCTATTATGA
TGGTAGCTGTTGTGATGTGGCGATCTCTGATCTAGAAACCCCTGAGGGGCCATTGTGGCCTGCCCAGTCTCCCGGCCACGGTTGAAACCA
GACGTGCAGTGGGGCTGACCCCTGTGCCCCACCCCAGAGTCATGCCAGCGTGGGTGGTGGGGCATTCTCTGGGATGAATGATCTGGATCC
CATAGCCATCTGTGTCCTGTTTGAGGAATGGGACCCTCAAACAGAGAACAGCCAAGATGCTCAAGCAGGTGTGTGCTTGGGCCAGACTCT
GCAGCCTTTGGTTTGGGACTTGACTGCCATTCACTGAAGGGGCCCAGGAAATGGGCAGCTCACATGGTGTTGCTGGGTGTCCAGCTGCGG
CAGTTTAGCAGAGGAGGACTTGTAATGAGATGGTAGCTTCTTATAGGCTAAGACATGATTTTTCTGTTCTTTTACTACCTCCTGCACCTT
CTAGAACTGTTCCTTCTCTGATGCTGTTTTCCTTTCTTCCAGTGATTTATCTCTAGGGTCTCCATAGCAGGGGAGGTAGGGTCAGACTCC
TGAGATGGCTGATGTCCTACCCTGCCCCCAACCAGGGGCCCCAGGAGACTCCTTTTTCTTACTGCAACTTTGGCCTCCTCAGTCTGCAGA
TCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGG
GGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCAACACTGCAGAAGATGCTAAAGATGTGATTAAAGAGATTGAAGACTTTGACAGC
TTGGAGGCTCTGCGTCTGGAAGGCAACACAGTGGGCGTGGAAGCAGCCAGGGTCATCGCCAAGGCCTTAGAGAAGAAGTCGGAGTTGAAG
CGCTGCCACTGGAGTGACATGTTCACGGGAAGGCTGCGGACCGAGATCCCACCAGCCCTGAAAGAGAAGATCCGGGAGAAGTTCGTGGAA
GCCCTGAAAACAGAGTTTGCTGGCAAAGGGCTGAGGTTCTCTCGAGGAGGCATGATCAGCTTTGACGTCTTCCCCGAGGGCTGGGACAAG
CGCTACTGCCTGGATAGCCTGGACCAGGACAGCTTCGACACCATCCACTTCTTTGGGAACGAGACTAGCCCTGGTGGGAACGACTTTGAG
ATCTTTGCCGACCCCCGGACTGTTGGCCACAGCGTGGTGTCTCCTCAGGACACGGTGCAGCGATGCCGGGAGATTTTCTTCCCAGAGACA
GCTCATGAGGCGTGACCGGGGCCCACATCTGTGTGTCGTGACTTCTGAAGAGTTTGGCCTAGGCCTAAAGAGAGGTCCTGGTGTTGGATA
GATGCCAGGGCCCCTCCTCTGGCCCAGGACGCCTGCTGCAAGCCCACCCAGATGGGGCCAGAGTCTGTGTGGACAACCGTCCCCAGCCAG
TCTGCTCCTAGTGGCACTGGCTTCGTCCTCCCAGGGCCCAGAGTGTTCCCCATGCTCCACCTGGTGGCCCAGGCCACAGCTGCTGCTTGT
ATTTCGGTACAGAAGAGGTTTCTTTCTGCACCAGGAGGAGGCGTGCTCAAGTATCGGTACGAGATCTAGCCTGCCCTGCCTGCCTGCCCT

>72115_72115_4_RANGAP1-PMM1_RANGAP1_chr22_41664101_ENST00000455915_PMM1_chr22_41974885_ENST00000216259_length(amino acids)=237AA_BP=133
MPPTRGPRRLLFLTATLASSVCRSPGEPTSLVNMASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDAKDVIKEIEDFDSLEALRLE
GNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALKEKIREKFVEALKTEFAGKGLRFSRGGMISFDVFPEGWDKRYCLDSL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RANGAP1-PMM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RANGAP1-PMM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RANGAP1-PMM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource