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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAP1GAP2-TEKT1 (FusionGDB2 ID:72168)

Fusion Gene Summary for RAP1GAP2-TEKT1

check button Fusion gene summary
Fusion gene informationFusion gene name: RAP1GAP2-TEKT1
Fusion gene ID: 72168
HgeneTgene
Gene symbol

RAP1GAP2

TEKT1

Gene ID

23108

83659

Gene nameRAP1 GTPase activating protein 2tektin 1
SynonymsGARNL4|RAP1GA3-
Cytomap

17p13.3

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionrap1 GTPase-activating protein 2GTPase activating RANGAP domain-like 4GTPase activating Rap/RanGAP domain-like 4GTPase-activating Rap/Ran-GAP domain-like protein 4tektin-1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000254695, ENST00000366401, 
ENST00000540393, ENST00000542807, 
ENST00000574709, 		ENST00000535086, 
ENST00000338694, 
Fusion gene scores* DoF score10 X 10 X 3=3005 X 4 X 4=80
# samples 106
** MAII scorelog2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAP1GAP2 [Title/Abstract] AND TEKT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAP1GAP2(2703844)-TEKT1(6719281), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RAP1GAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TEKT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1702-01ARAP1GAP2chr17

2703844

+TEKT1chr17

6719281

-


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Fusion Gene ORF analysis for RAP1GAP2-TEKT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000254695ENST00000535086RAP1GAP2chr17

2703844

+TEKT1chr17

6719281

-
5CDS-5UTRENST00000366401ENST00000535086RAP1GAP2chr17

2703844

+TEKT1chr17

6719281

-
5CDS-5UTRENST00000540393ENST00000535086RAP1GAP2chr17

2703844

+TEKT1chr17

6719281

-
5CDS-5UTRENST00000542807ENST00000535086RAP1GAP2chr17

2703844

+TEKT1chr17

6719281

-
In-frameENST00000254695ENST00000338694RAP1GAP2chr17

2703844

+TEKT1chr17

6719281

-
In-frameENST00000366401ENST00000338694RAP1GAP2chr17

2703844

+TEKT1chr17

6719281

-
In-frameENST00000540393ENST00000338694RAP1GAP2chr17

2703844

+TEKT1chr17

6719281

-
In-frameENST00000542807ENST00000338694RAP1GAP2chr17

2703844

+TEKT1chr17

6719281

-
intron-3CDSENST00000574709ENST00000338694RAP1GAP2chr17

2703844

+TEKT1chr17

6719281

-
intron-5UTRENST00000574709ENST00000535086RAP1GAP2chr17

2703844

+TEKT1chr17

6719281

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540393RAP1GAP2chr172703844+ENST00000338694TEKT1chr176719281-31942591251159344
ENST00000254695RAP1GAP2chr172703844+ENST00000338694TEKT1chr176719281-3105170901070326
ENST00000366401RAP1GAP2chr172703844+ENST00000338694TEKT1chr176719281-3105170901070326
ENST00000542807RAP1GAP2chr172703844+ENST00000338694TEKT1chr176719281-3061126461026326

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540393ENST00000338694RAP1GAP2chr172703844+TEKT1chr176719281-0.0010014680.9989986
ENST00000254695ENST00000338694RAP1GAP2chr172703844+TEKT1chr176719281-0.0008233620.99917656
ENST00000366401ENST00000338694RAP1GAP2chr172703844+TEKT1chr176719281-0.0008233620.99917656
ENST00000542807ENST00000338694RAP1GAP2chr172703844+TEKT1chr176719281-0.000811620.99918836

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Fusion Genomic Features for RAP1GAP2-TEKT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAP1GAP2-TEKT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:2703844/chr17:6719281)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTEKT1chr17:2703844chr17:6719281ENST0000033869428134_177118419.0Coiled coilOntology_term=ECO:0000255
TgeneTEKT1chr17:2703844chr17:6719281ENST0000033869428266_308118419.0Coiled coilOntology_term=ECO:0000255
TgeneTEKT1chr17:2703844chr17:6719281ENST0000033869428333_384118419.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAP1GAP2chr17:2703844chr17:6719281ENST00000254695+225586_726262135.6666666666665Compositional biasNote=Ser-rich
HgeneRAP1GAP2chr17:2703844chr17:6719281ENST00000366401+224586_726262120.6666666666665Compositional biasNote=Ser-rich
HgeneRAP1GAP2chr17:2703844chr17:6719281ENST00000540393+225586_7267909.6666666666666Compositional biasNote=Ser-rich
HgeneRAP1GAP2chr17:2703844chr17:6719281ENST00000542807+226586_72626969.3333333333334Compositional biasNote=Ser-rich
HgeneRAP1GAP2chr17:2703844chr17:6719281ENST00000254695+225248_464262135.6666666666665DomainRap-GAP
HgeneRAP1GAP2chr17:2703844chr17:6719281ENST00000366401+224248_464262120.6666666666665DomainRap-GAP
HgeneRAP1GAP2chr17:2703844chr17:6719281ENST00000540393+225248_4647909.6666666666666DomainRap-GAP
HgeneRAP1GAP2chr17:2703844chr17:6719281ENST00000542807+226248_46426969.3333333333334DomainRap-GAP
TgeneTEKT1chr17:2703844chr17:6719281ENST000003386942821_107118419.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for RAP1GAP2-TEKT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72168_72168_1_RAP1GAP2-TEKT1_RAP1GAP2_chr17_2703844_ENST00000254695_TEKT1_chr17_6719281_ENST00000338694_length(transcript)=3105nt_BP=170nt
ACTGACCCCGCTGTACCACGGCCCTCTTGCGGACAGCCCCGGGGACGTCGTTGGGACATCGCTGGGACCCCGGGCTCTGCAGCCACAACC
ATGTTTGGCCGGAAGCGCAGTGTCTCCTTTGGGGGCTTCGGATGGATCGACAAGACCATGCTGGCAAGTCTGAAGGTCAAGGAGAAGCGC
ATTGGCATTGACCTGGTGCACGACACAGTGGAGCATGAGCTGATAAAGGAGGCTGAGATCATCCAGGGCATTATGGCTCTGCTGACCCGT
ACCTTGGAGGAGGCTTCCGAGCAGATTCGGATGAACCGCTCTGCCAAGTACAATCTTGAGAAGGATTTGAAGGACAAGTTTGTGGCCCTG
ACCATAGATGATATCTGCTTCTCGCTCAACAACAACTCACCAAACATCAGATATTCTGAGAACGCCGTGAGGATTGAGCCAAACTCCGTG
AGTCTGGAAGACTGGTTGGACTTCTCCAGCACCAATGTGGAGAAGGCTGACAAGCAGCGGAACAACTCCCTGATGCTGAAAGCCCTGGTG
GATCGAATCCTGTCCCAGACAGCCAATGATCTGCGCAAGCAGTGTGATGTGGTGGACACGGCATTCAAGAATGGGCTGAAGGATACAAAG
GATGCCAGGGACAAGCTGGCTGATCATCTGGCCAAGGTCATGGAAGAGATTGCTTCCCAGGAGAAAAATATTACAGCTCTTGAAAAGGCC
ATCCTTGACCAAGAAGGGCCAGCCAAGGTGGCTCATACGCGCTTGGAGACCAGGACACACCGGCCGAACGTGGAGCTGTGTCGTGATGTC
GCACAATATAGGCTAATGAAGGAGGTTCAAGAGATCACCCACAATGTCGCAAGATTGAAGGAAACTTTAGCCCAAGCTCAGGCAGAGCTG
AAAGGGCTGCATCGCAGACAGCTTGCCCTGCAGGAGGAGATCCAGGTCAAAGAGAACACCATTTATATCGACGAAGTGCTGTGTATGCAG
ATGAGGAAATCCATCCCACTTCGGGATGGGGAAGACCATGGGGTCTGGGCTGGGGGCCTCCGCCCTGATGCTGTCTGCTAATAGTAGGGC
TAGTTCCAATTCTCATTAAACCACATTGTAAACAGTAGTTACAGTAGTACAGAGCTCTCATTTCAGGCTGGCGGGGCCTCTAGCCAGCCT
GCTGCAACCTCTTGGCTGGCATTCCAAGCCTGCTCAGGGGGCTGATTTTGGGGCGAGTTTCTTCTCTTATGCTGGTGTGGTGTTTGCCTA
ACAATTCAACTCCATATTTTAGCACAGGCCACTCTTACAATATCACAGGACTTGGGGCCCCAGGACAGGGTTTCAAGACATTTCAGTTCA
GATTCAATTCAATAAAGTAGTTGGGCTGGATCACCTGTGTAGACCATGCCCCTCTTGCTCATGAGATGGGATGCTAACCTTTCTCTTGGC
TCTCAAAATTTCTTTTCTCTAGAAAATAATGTGTTTTTTTTCTCTTAAATACTCAAATAACATAAAGAAAAAGAACAAAATTCCATTCAT
TCAAGTCAATGGGTTCAAGTCAATGGTTAAGACTGTAGGTTCCGGAGTCTGCCATCTGAGTATAGGACCTCCAATAGTCCCCACTCACAG
GGCTATAGGGGCGTTGAATGAGATCACCTCCGTAAAGGGCTTCATACTGAGCCTGTATCATGGGGCAGTGAGTGTTTAATGAATGTGAGC
CATTGTGAGCAGTCCCACCCTATACCAACATAATTTCTGCACAATTGTACTCATGGCATAAACTCAATTTCAGGATTATTTTTTTCCTTC
ACTGCTAATTATTGCAAGCCTTTGTTCATGTTGCTAAATTGTCTTTATAATTATTTTAATGGTTACGTACCTCTTTACAAGTTTTCAGCA
AGACTGTTTTATATACTTACTGTTTCTTTTCCAAAAAGAGTTCAACTTGTGGGAGGCTGCCTTCCGCTGAGCTGCAGCAGGTCAGAGATC
TATGTGGGTGACTGTCAAAGGAAGACATTTGCTGTGGGAAACTGCTCATTTGTTCCTTATTCCGCTAACATTGAAGGAACACTTTCCATG
GACGAGGCTTACCATCTCAGCACCCTCCCATGTGTGAAGCTGCTGCTACACTCTGCTAACATTTGGTTCCCCGGTGCTCATGGACAGCTG
ACGGTGTGGGGCTCAGGAGACCTAGCTTCTAGTTGCAACACTGCCAGGAAAGTTTCTCTCCTTCTTTAGGACCACCTGTAAAGTAAGGAA
AGGACTATATCGTCTGGAACTCTTCCTGTCCTTGCTGTTCCCTGAATCTGGCTGTCTAGCTGCACATACGGTGTCATAGGGCACAATGAT
AATGCAGAGTGTGGGCCTAATTCCTGGGAGCTTTGCAATCTAGGTGCTCCTTGGTCCAGAGACTCTTTGCCATCAGAAAGGGATGTTCCC
AATCTGGGATGGAGAAACCCCCTTTGAGGCCAAAAGCACTGGCTTAATTCTGTTAATTCTGATCTATGCCACCCCAGTGCTGAACGTCTC
CTCTCAGAGTGCTCAGCAAATACACAGCCCTTCCCATGCCTCAATCAAGGAGGGAGGCCCCTCTCTGCTCACTGGGAAGCCTCTGGGTGC
TTTTCTGCTCTGGCTCGGAAGAGTCCAAATAAGCCTTCCCAGCTCACTGGGCAGACCTCAGAGTTTCTGCTAACTTAGCAGGGTTTTGAG
GTCTGTCCCAGAGGATGTGGCTGGCAGGGTGTGAAGACACTGGGCAAAATCCTTCCTTGTGAATACAGCTCTCAGAGGCAGCCAGCCTCA
GTGGTGGATTCAGATCCCAGGCTCTGCAGGGAGATGTGATTCAGATCAGCTGGTGGATCAGCTCCACGCTCTACCTGTGATGTGATCCCC
GCCAAGTTACTCAACTTCCCCGAGCTTCAGTTGCCTAATCTGTAAATAAGACTAATAAAGCCTAGATTGGCGAGATAACGTGTGGAAGAC
TCTCAACACAGTGTCTGGAACATGCTGCTTTTAAGGGAAATGTGATTTTGATTATGGTTGAGGCCATTTCTCAACATGTAGACATAAAAT

>72168_72168_1_RAP1GAP2-TEKT1_RAP1GAP2_chr17_2703844_ENST00000254695_TEKT1_chr17_6719281_ENST00000338694_length(amino acids)=326AA_BP=27
MFGRKRSVSFGGFGWIDKTMLASLKVKEKRIGIDLVHDTVEHELIKEAEIIQGIMALLTRTLEEASEQIRMNRSAKYNLEKDLKDKFVAL
TIDDICFSLNNNSPNIRYSENAVRIEPNSVSLEDWLDFSSTNVEKADKQRNNSLMLKALVDRILSQTANDLRKQCDVVDTAFKNGLKDTK
DARDKLADHLAKVMEEIASQEKNITALEKAILDQEGPAKVAHTRLETRTHRPNVELCRDVAQYRLMKEVQEITHNVARLKETLAQAQAEL

--------------------------------------------------------------
>72168_72168_2_RAP1GAP2-TEKT1_RAP1GAP2_chr17_2703844_ENST00000366401_TEKT1_chr17_6719281_ENST00000338694_length(transcript)=3105nt_BP=170nt
ACTGACCCCGCTGTACCACGGCCCTCTTGCGGACAGCCCCGGGGACGTCGTTGGGACATCGCTGGGACCCCGGGCTCTGCAGCCACAACC
ATGTTTGGCCGGAAGCGCAGTGTCTCCTTTGGGGGCTTCGGATGGATCGACAAGACCATGCTGGCAAGTCTGAAGGTCAAGGAGAAGCGC
ATTGGCATTGACCTGGTGCACGACACAGTGGAGCATGAGCTGATAAAGGAGGCTGAGATCATCCAGGGCATTATGGCTCTGCTGACCCGT
ACCTTGGAGGAGGCTTCCGAGCAGATTCGGATGAACCGCTCTGCCAAGTACAATCTTGAGAAGGATTTGAAGGACAAGTTTGTGGCCCTG
ACCATAGATGATATCTGCTTCTCGCTCAACAACAACTCACCAAACATCAGATATTCTGAGAACGCCGTGAGGATTGAGCCAAACTCCGTG
AGTCTGGAAGACTGGTTGGACTTCTCCAGCACCAATGTGGAGAAGGCTGACAAGCAGCGGAACAACTCCCTGATGCTGAAAGCCCTGGTG
GATCGAATCCTGTCCCAGACAGCCAATGATCTGCGCAAGCAGTGTGATGTGGTGGACACGGCATTCAAGAATGGGCTGAAGGATACAAAG
GATGCCAGGGACAAGCTGGCTGATCATCTGGCCAAGGTCATGGAAGAGATTGCTTCCCAGGAGAAAAATATTACAGCTCTTGAAAAGGCC
ATCCTTGACCAAGAAGGGCCAGCCAAGGTGGCTCATACGCGCTTGGAGACCAGGACACACCGGCCGAACGTGGAGCTGTGTCGTGATGTC
GCACAATATAGGCTAATGAAGGAGGTTCAAGAGATCACCCACAATGTCGCAAGATTGAAGGAAACTTTAGCCCAAGCTCAGGCAGAGCTG
AAAGGGCTGCATCGCAGACAGCTTGCCCTGCAGGAGGAGATCCAGGTCAAAGAGAACACCATTTATATCGACGAAGTGCTGTGTATGCAG
ATGAGGAAATCCATCCCACTTCGGGATGGGGAAGACCATGGGGTCTGGGCTGGGGGCCTCCGCCCTGATGCTGTCTGCTAATAGTAGGGC
TAGTTCCAATTCTCATTAAACCACATTGTAAACAGTAGTTACAGTAGTACAGAGCTCTCATTTCAGGCTGGCGGGGCCTCTAGCCAGCCT
GCTGCAACCTCTTGGCTGGCATTCCAAGCCTGCTCAGGGGGCTGATTTTGGGGCGAGTTTCTTCTCTTATGCTGGTGTGGTGTTTGCCTA
ACAATTCAACTCCATATTTTAGCACAGGCCACTCTTACAATATCACAGGACTTGGGGCCCCAGGACAGGGTTTCAAGACATTTCAGTTCA
GATTCAATTCAATAAAGTAGTTGGGCTGGATCACCTGTGTAGACCATGCCCCTCTTGCTCATGAGATGGGATGCTAACCTTTCTCTTGGC
TCTCAAAATTTCTTTTCTCTAGAAAATAATGTGTTTTTTTTCTCTTAAATACTCAAATAACATAAAGAAAAAGAACAAAATTCCATTCAT
TCAAGTCAATGGGTTCAAGTCAATGGTTAAGACTGTAGGTTCCGGAGTCTGCCATCTGAGTATAGGACCTCCAATAGTCCCCACTCACAG
GGCTATAGGGGCGTTGAATGAGATCACCTCCGTAAAGGGCTTCATACTGAGCCTGTATCATGGGGCAGTGAGTGTTTAATGAATGTGAGC
CATTGTGAGCAGTCCCACCCTATACCAACATAATTTCTGCACAATTGTACTCATGGCATAAACTCAATTTCAGGATTATTTTTTTCCTTC
ACTGCTAATTATTGCAAGCCTTTGTTCATGTTGCTAAATTGTCTTTATAATTATTTTAATGGTTACGTACCTCTTTACAAGTTTTCAGCA
AGACTGTTTTATATACTTACTGTTTCTTTTCCAAAAAGAGTTCAACTTGTGGGAGGCTGCCTTCCGCTGAGCTGCAGCAGGTCAGAGATC
TATGTGGGTGACTGTCAAAGGAAGACATTTGCTGTGGGAAACTGCTCATTTGTTCCTTATTCCGCTAACATTGAAGGAACACTTTCCATG
GACGAGGCTTACCATCTCAGCACCCTCCCATGTGTGAAGCTGCTGCTACACTCTGCTAACATTTGGTTCCCCGGTGCTCATGGACAGCTG
ACGGTGTGGGGCTCAGGAGACCTAGCTTCTAGTTGCAACACTGCCAGGAAAGTTTCTCTCCTTCTTTAGGACCACCTGTAAAGTAAGGAA
AGGACTATATCGTCTGGAACTCTTCCTGTCCTTGCTGTTCCCTGAATCTGGCTGTCTAGCTGCACATACGGTGTCATAGGGCACAATGAT
AATGCAGAGTGTGGGCCTAATTCCTGGGAGCTTTGCAATCTAGGTGCTCCTTGGTCCAGAGACTCTTTGCCATCAGAAAGGGATGTTCCC
AATCTGGGATGGAGAAACCCCCTTTGAGGCCAAAAGCACTGGCTTAATTCTGTTAATTCTGATCTATGCCACCCCAGTGCTGAACGTCTC
CTCTCAGAGTGCTCAGCAAATACACAGCCCTTCCCATGCCTCAATCAAGGAGGGAGGCCCCTCTCTGCTCACTGGGAAGCCTCTGGGTGC
TTTTCTGCTCTGGCTCGGAAGAGTCCAAATAAGCCTTCCCAGCTCACTGGGCAGACCTCAGAGTTTCTGCTAACTTAGCAGGGTTTTGAG
GTCTGTCCCAGAGGATGTGGCTGGCAGGGTGTGAAGACACTGGGCAAAATCCTTCCTTGTGAATACAGCTCTCAGAGGCAGCCAGCCTCA
GTGGTGGATTCAGATCCCAGGCTCTGCAGGGAGATGTGATTCAGATCAGCTGGTGGATCAGCTCCACGCTCTACCTGTGATGTGATCCCC
GCCAAGTTACTCAACTTCCCCGAGCTTCAGTTGCCTAATCTGTAAATAAGACTAATAAAGCCTAGATTGGCGAGATAACGTGTGGAAGAC
TCTCAACACAGTGTCTGGAACATGCTGCTTTTAAGGGAAATGTGATTTTGATTATGGTTGAGGCCATTTCTCAACATGTAGACATAAAAT

>72168_72168_2_RAP1GAP2-TEKT1_RAP1GAP2_chr17_2703844_ENST00000366401_TEKT1_chr17_6719281_ENST00000338694_length(amino acids)=326AA_BP=27
MFGRKRSVSFGGFGWIDKTMLASLKVKEKRIGIDLVHDTVEHELIKEAEIIQGIMALLTRTLEEASEQIRMNRSAKYNLEKDLKDKFVAL
TIDDICFSLNNNSPNIRYSENAVRIEPNSVSLEDWLDFSSTNVEKADKQRNNSLMLKALVDRILSQTANDLRKQCDVVDTAFKNGLKDTK
DARDKLADHLAKVMEEIASQEKNITALEKAILDQEGPAKVAHTRLETRTHRPNVELCRDVAQYRLMKEVQEITHNVARLKETLAQAQAEL

--------------------------------------------------------------
>72168_72168_3_RAP1GAP2-TEKT1_RAP1GAP2_chr17_2703844_ENST00000540393_TEKT1_chr17_6719281_ENST00000338694_length(transcript)=3194nt_BP=259nt
GCAGACAGACATCGGCACGTATGGACGGCGCGAGCCGGTACTGCGTTCCGGAGGAGCCATCCGGCGTCACAGGCTGTGCTGGGGAGGTGG
GGTGACCGTCCTCAGAAACCCCCGCGGGCGGGGCGCTGCACACACGTCCACCTATAGGGTGTGTGTGCGTGCGTGAGGTGTGCAGCCCCT
GTCAGGATCTGGCGAGAGAAGCTGACCGGGATGGAGGTCAGAGGATCGACAAGACCATGCTGGCAAGTCTGAAGGTCAAGGAGAAGCGCA
TTGGCATTGACCTGGTGCACGACACAGTGGAGCATGAGCTGATAAAGGAGGCTGAGATCATCCAGGGCATTATGGCTCTGCTGACCCGTA
CCTTGGAGGAGGCTTCCGAGCAGATTCGGATGAACCGCTCTGCCAAGTACAATCTTGAGAAGGATTTGAAGGACAAGTTTGTGGCCCTGA
CCATAGATGATATCTGCTTCTCGCTCAACAACAACTCACCAAACATCAGATATTCTGAGAACGCCGTGAGGATTGAGCCAAACTCCGTGA
GTCTGGAAGACTGGTTGGACTTCTCCAGCACCAATGTGGAGAAGGCTGACAAGCAGCGGAACAACTCCCTGATGCTGAAAGCCCTGGTGG
ATCGAATCCTGTCCCAGACAGCCAATGATCTGCGCAAGCAGTGTGATGTGGTGGACACGGCATTCAAGAATGGGCTGAAGGATACAAAGG
ATGCCAGGGACAAGCTGGCTGATCATCTGGCCAAGGTCATGGAAGAGATTGCTTCCCAGGAGAAAAATATTACAGCTCTTGAAAAGGCCA
TCCTTGACCAAGAAGGGCCAGCCAAGGTGGCTCATACGCGCTTGGAGACCAGGACACACCGGCCGAACGTGGAGCTGTGTCGTGATGTCG
CACAATATAGGCTAATGAAGGAGGTTCAAGAGATCACCCACAATGTCGCAAGATTGAAGGAAACTTTAGCCCAAGCTCAGGCAGAGCTGA
AAGGGCTGCATCGCAGACAGCTTGCCCTGCAGGAGGAGATCCAGGTCAAAGAGAACACCATTTATATCGACGAAGTGCTGTGTATGCAGA
TGAGGAAATCCATCCCACTTCGGGATGGGGAAGACCATGGGGTCTGGGCTGGGGGCCTCCGCCCTGATGCTGTCTGCTAATAGTAGGGCT
AGTTCCAATTCTCATTAAACCACATTGTAAACAGTAGTTACAGTAGTACAGAGCTCTCATTTCAGGCTGGCGGGGCCTCTAGCCAGCCTG
CTGCAACCTCTTGGCTGGCATTCCAAGCCTGCTCAGGGGGCTGATTTTGGGGCGAGTTTCTTCTCTTATGCTGGTGTGGTGTTTGCCTAA
CAATTCAACTCCATATTTTAGCACAGGCCACTCTTACAATATCACAGGACTTGGGGCCCCAGGACAGGGTTTCAAGACATTTCAGTTCAG
ATTCAATTCAATAAAGTAGTTGGGCTGGATCACCTGTGTAGACCATGCCCCTCTTGCTCATGAGATGGGATGCTAACCTTTCTCTTGGCT
CTCAAAATTTCTTTTCTCTAGAAAATAATGTGTTTTTTTTCTCTTAAATACTCAAATAACATAAAGAAAAAGAACAAAATTCCATTCATT
CAAGTCAATGGGTTCAAGTCAATGGTTAAGACTGTAGGTTCCGGAGTCTGCCATCTGAGTATAGGACCTCCAATAGTCCCCACTCACAGG
GCTATAGGGGCGTTGAATGAGATCACCTCCGTAAAGGGCTTCATACTGAGCCTGTATCATGGGGCAGTGAGTGTTTAATGAATGTGAGCC
ATTGTGAGCAGTCCCACCCTATACCAACATAATTTCTGCACAATTGTACTCATGGCATAAACTCAATTTCAGGATTATTTTTTTCCTTCA
CTGCTAATTATTGCAAGCCTTTGTTCATGTTGCTAAATTGTCTTTATAATTATTTTAATGGTTACGTACCTCTTTACAAGTTTTCAGCAA
GACTGTTTTATATACTTACTGTTTCTTTTCCAAAAAGAGTTCAACTTGTGGGAGGCTGCCTTCCGCTGAGCTGCAGCAGGTCAGAGATCT
ATGTGGGTGACTGTCAAAGGAAGACATTTGCTGTGGGAAACTGCTCATTTGTTCCTTATTCCGCTAACATTGAAGGAACACTTTCCATGG
ACGAGGCTTACCATCTCAGCACCCTCCCATGTGTGAAGCTGCTGCTACACTCTGCTAACATTTGGTTCCCCGGTGCTCATGGACAGCTGA
CGGTGTGGGGCTCAGGAGACCTAGCTTCTAGTTGCAACACTGCCAGGAAAGTTTCTCTCCTTCTTTAGGACCACCTGTAAAGTAAGGAAA
GGACTATATCGTCTGGAACTCTTCCTGTCCTTGCTGTTCCCTGAATCTGGCTGTCTAGCTGCACATACGGTGTCATAGGGCACAATGATA
ATGCAGAGTGTGGGCCTAATTCCTGGGAGCTTTGCAATCTAGGTGCTCCTTGGTCCAGAGACTCTTTGCCATCAGAAAGGGATGTTCCCA
ATCTGGGATGGAGAAACCCCCTTTGAGGCCAAAAGCACTGGCTTAATTCTGTTAATTCTGATCTATGCCACCCCAGTGCTGAACGTCTCC
TCTCAGAGTGCTCAGCAAATACACAGCCCTTCCCATGCCTCAATCAAGGAGGGAGGCCCCTCTCTGCTCACTGGGAAGCCTCTGGGTGCT
TTTCTGCTCTGGCTCGGAAGAGTCCAAATAAGCCTTCCCAGCTCACTGGGCAGACCTCAGAGTTTCTGCTAACTTAGCAGGGTTTTGAGG
TCTGTCCCAGAGGATGTGGCTGGCAGGGTGTGAAGACACTGGGCAAAATCCTTCCTTGTGAATACAGCTCTCAGAGGCAGCCAGCCTCAG
TGGTGGATTCAGATCCCAGGCTCTGCAGGGAGATGTGATTCAGATCAGCTGGTGGATCAGCTCCACGCTCTACCTGTGATGTGATCCCCG
CCAAGTTACTCAACTTCCCCGAGCTTCAGTTGCCTAATCTGTAAATAAGACTAATAAAGCCTAGATTGGCGAGATAACGTGTGGAAGACT
CTCAACACAGTGTCTGGAACATGCTGCTTTTAAGGGAAATGTGATTTTGATTATGGTTGAGGCCATTTCTCAACATGTAGACATAAAATG

>72168_72168_3_RAP1GAP2-TEKT1_RAP1GAP2_chr17_2703844_ENST00000540393_TEKT1_chr17_6719281_ENST00000338694_length(amino acids)=344AA_BP=45
MHTRPPIGCVCVREVCSPCQDLAREADRDGGQRIDKTMLASLKVKEKRIGIDLVHDTVEHELIKEAEIIQGIMALLTRTLEEASEQIRMN
RSAKYNLEKDLKDKFVALTIDDICFSLNNNSPNIRYSENAVRIEPNSVSLEDWLDFSSTNVEKADKQRNNSLMLKALVDRILSQTANDLR
KQCDVVDTAFKNGLKDTKDARDKLADHLAKVMEEIASQEKNITALEKAILDQEGPAKVAHTRLETRTHRPNVELCRDVAQYRLMKEVQEI

--------------------------------------------------------------
>72168_72168_4_RAP1GAP2-TEKT1_RAP1GAP2_chr17_2703844_ENST00000542807_TEKT1_chr17_6719281_ENST00000338694_length(transcript)=3061nt_BP=126nt
ACGTCGTTGGGACATCGCTGGGACCCCGGGCTCTGCAGCCACAACCATGTTTGGCCGGAAGCGCAGTGTCTCCTTTGGGGGCTTCGGATG
GATCGACAAGACCATGCTGGCAAGTCTGAAGGTCAAGGAGAAGCGCATTGGCATTGACCTGGTGCACGACACAGTGGAGCATGAGCTGAT
AAAGGAGGCTGAGATCATCCAGGGCATTATGGCTCTGCTGACCCGTACCTTGGAGGAGGCTTCCGAGCAGATTCGGATGAACCGCTCTGC
CAAGTACAATCTTGAGAAGGATTTGAAGGACAAGTTTGTGGCCCTGACCATAGATGATATCTGCTTCTCGCTCAACAACAACTCACCAAA
CATCAGATATTCTGAGAACGCCGTGAGGATTGAGCCAAACTCCGTGAGTCTGGAAGACTGGTTGGACTTCTCCAGCACCAATGTGGAGAA
GGCTGACAAGCAGCGGAACAACTCCCTGATGCTGAAAGCCCTGGTGGATCGAATCCTGTCCCAGACAGCCAATGATCTGCGCAAGCAGTG
TGATGTGGTGGACACGGCATTCAAGAATGGGCTGAAGGATACAAAGGATGCCAGGGACAAGCTGGCTGATCATCTGGCCAAGGTCATGGA
AGAGATTGCTTCCCAGGAGAAAAATATTACAGCTCTTGAAAAGGCCATCCTTGACCAAGAAGGGCCAGCCAAGGTGGCTCATACGCGCTT
GGAGACCAGGACACACCGGCCGAACGTGGAGCTGTGTCGTGATGTCGCACAATATAGGCTAATGAAGGAGGTTCAAGAGATCACCCACAA
TGTCGCAAGATTGAAGGAAACTTTAGCCCAAGCTCAGGCAGAGCTGAAAGGGCTGCATCGCAGACAGCTTGCCCTGCAGGAGGAGATCCA
GGTCAAAGAGAACACCATTTATATCGACGAAGTGCTGTGTATGCAGATGAGGAAATCCATCCCACTTCGGGATGGGGAAGACCATGGGGT
CTGGGCTGGGGGCCTCCGCCCTGATGCTGTCTGCTAATAGTAGGGCTAGTTCCAATTCTCATTAAACCACATTGTAAACAGTAGTTACAG
TAGTACAGAGCTCTCATTTCAGGCTGGCGGGGCCTCTAGCCAGCCTGCTGCAACCTCTTGGCTGGCATTCCAAGCCTGCTCAGGGGGCTG
ATTTTGGGGCGAGTTTCTTCTCTTATGCTGGTGTGGTGTTTGCCTAACAATTCAACTCCATATTTTAGCACAGGCCACTCTTACAATATC
ACAGGACTTGGGGCCCCAGGACAGGGTTTCAAGACATTTCAGTTCAGATTCAATTCAATAAAGTAGTTGGGCTGGATCACCTGTGTAGAC
CATGCCCCTCTTGCTCATGAGATGGGATGCTAACCTTTCTCTTGGCTCTCAAAATTTCTTTTCTCTAGAAAATAATGTGTTTTTTTTCTC
TTAAATACTCAAATAACATAAAGAAAAAGAACAAAATTCCATTCATTCAAGTCAATGGGTTCAAGTCAATGGTTAAGACTGTAGGTTCCG
GAGTCTGCCATCTGAGTATAGGACCTCCAATAGTCCCCACTCACAGGGCTATAGGGGCGTTGAATGAGATCACCTCCGTAAAGGGCTTCA
TACTGAGCCTGTATCATGGGGCAGTGAGTGTTTAATGAATGTGAGCCATTGTGAGCAGTCCCACCCTATACCAACATAATTTCTGCACAA
TTGTACTCATGGCATAAACTCAATTTCAGGATTATTTTTTTCCTTCACTGCTAATTATTGCAAGCCTTTGTTCATGTTGCTAAATTGTCT
TTATAATTATTTTAATGGTTACGTACCTCTTTACAAGTTTTCAGCAAGACTGTTTTATATACTTACTGTTTCTTTTCCAAAAAGAGTTCA
ACTTGTGGGAGGCTGCCTTCCGCTGAGCTGCAGCAGGTCAGAGATCTATGTGGGTGACTGTCAAAGGAAGACATTTGCTGTGGGAAACTG
CTCATTTGTTCCTTATTCCGCTAACATTGAAGGAACACTTTCCATGGACGAGGCTTACCATCTCAGCACCCTCCCATGTGTGAAGCTGCT
GCTACACTCTGCTAACATTTGGTTCCCCGGTGCTCATGGACAGCTGACGGTGTGGGGCTCAGGAGACCTAGCTTCTAGTTGCAACACTGC
CAGGAAAGTTTCTCTCCTTCTTTAGGACCACCTGTAAAGTAAGGAAAGGACTATATCGTCTGGAACTCTTCCTGTCCTTGCTGTTCCCTG
AATCTGGCTGTCTAGCTGCACATACGGTGTCATAGGGCACAATGATAATGCAGAGTGTGGGCCTAATTCCTGGGAGCTTTGCAATCTAGG
TGCTCCTTGGTCCAGAGACTCTTTGCCATCAGAAAGGGATGTTCCCAATCTGGGATGGAGAAACCCCCTTTGAGGCCAAAAGCACTGGCT
TAATTCTGTTAATTCTGATCTATGCCACCCCAGTGCTGAACGTCTCCTCTCAGAGTGCTCAGCAAATACACAGCCCTTCCCATGCCTCAA
TCAAGGAGGGAGGCCCCTCTCTGCTCACTGGGAAGCCTCTGGGTGCTTTTCTGCTCTGGCTCGGAAGAGTCCAAATAAGCCTTCCCAGCT
CACTGGGCAGACCTCAGAGTTTCTGCTAACTTAGCAGGGTTTTGAGGTCTGTCCCAGAGGATGTGGCTGGCAGGGTGTGAAGACACTGGG
CAAAATCCTTCCTTGTGAATACAGCTCTCAGAGGCAGCCAGCCTCAGTGGTGGATTCAGATCCCAGGCTCTGCAGGGAGATGTGATTCAG
ATCAGCTGGTGGATCAGCTCCACGCTCTACCTGTGATGTGATCCCCGCCAAGTTACTCAACTTCCCCGAGCTTCAGTTGCCTAATCTGTA
AATAAGACTAATAAAGCCTAGATTGGCGAGATAACGTGTGGAAGACTCTCAACACAGTGTCTGGAACATGCTGCTTTTAAGGGAAATGTG
ATTTTGATTATGGTTGAGGCCATTTCTCAACATGTAGACATAAAATGCGGAAACATCTAAGATTTCAATAAAGCAATGTTTTGTTAGTAA

>72168_72168_4_RAP1GAP2-TEKT1_RAP1GAP2_chr17_2703844_ENST00000542807_TEKT1_chr17_6719281_ENST00000338694_length(amino acids)=326AA_BP=27
MFGRKRSVSFGGFGWIDKTMLASLKVKEKRIGIDLVHDTVEHELIKEAEIIQGIMALLTRTLEEASEQIRMNRSAKYNLEKDLKDKFVAL
TIDDICFSLNNNSPNIRYSENAVRIEPNSVSLEDWLDFSSTNVEKADKQRNNSLMLKALVDRILSQTANDLRKQCDVVDTAFKNGLKDTK
DARDKLADHLAKVMEEIASQEKNITALEKAILDQEGPAKVAHTRLETRTHRPNVELCRDVAQYRLMKEVQEITHNVARLKETLAQAQAEL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RAP1GAP2-TEKT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAP1GAP2-TEKT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAP1GAP2-TEKT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource