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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAP1GAP-NIT2 (FusionGDB2 ID:72173)

Fusion Gene Summary for RAP1GAP-NIT2

check button Fusion gene summary
Fusion gene informationFusion gene name: RAP1GAP-NIT2
Fusion gene ID: 72173
HgeneTgene
Gene symbol

RAP1GAP

NIT2

Gene ID

5909

56954

Gene nameRAP1 GTPase activating proteinnitrilase family member 2
SynonymsRAP1GA1|RAP1GAP1|RAP1GAPII|RAPGAPHEL-S-8a
Cytomap

1p36.12

3q12.2

Type of geneprotein-codingprotein-coding
Descriptionrap1 GTPase-activating protein 1omega-amidase NIT2Nit protein 2epididymis secretory sperm binding protein Li 8anitrilase homolog 2
Modification date2020031320200313
UniProtAcc.

Q9NQR4

Ensembl transtripts involved in fusion geneENST00000290101, ENST00000374761, 
ENST00000374763, ENST00000374765, 
ENST00000542643, ENST00000374757, 
ENST00000394140, 
Fusion gene scores* DoF score7 X 10 X 7=4905 X 5 X 5=125
# samples 106
** MAII scorelog2(10/490*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAP1GAP [Title/Abstract] AND NIT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAP1GAP(21936068)-NIT2(100073616), # samples:3
Anticipated loss of major functional domain due to fusion event.RAP1GAP-NIT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RAP1GAP-NIT2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
RAP1GAP-NIT2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RAP1GAP-NIT2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAP1GAP

GO:0043087

regulation of GTPase activity

18309292

HgeneRAP1GAP

GO:0043547

positive regulation of GTPase activity

15141215

TgeneNIT2

GO:0006107

oxaloacetate metabolic process

22674578

TgeneNIT2

GO:0006528

asparagine metabolic process

22674578

TgeneNIT2

GO:0006541

glutamine metabolic process

22674578


check buttonFusion gene breakpoints across RAP1GAP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NIT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A6IW-01ARAP1GAPchr1

21936068

-NIT2chr3

100073616

+
ChimerDB4BRCATCGA-AC-A6IW-01ARAP1GAPchr1

21936613

-NIT2chr3

100073616

+
ChimerDB4BRCATCGA-AC-A6IW-01ARAP1GAPchr1

21937945

-NIT2chr3

100073616

+
ChimerDB4BRCATCGA-AC-A6IWRAP1GAPchr1

21936067

-NIT2chr3

100073615

+


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Fusion Gene ORF analysis for RAP1GAP-NIT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000290101ENST00000394140RAP1GAPchr1

21936068

-NIT2chr3

100073616

+
Frame-shiftENST00000290101ENST00000394140RAP1GAPchr1

21936613

-NIT2chr3

100073616

+
Frame-shiftENST00000290101ENST00000394140RAP1GAPchr1

21936067

-NIT2chr3

100073615

+
Frame-shiftENST00000374761ENST00000394140RAP1GAPchr1

21936068

-NIT2chr3

100073616

+
Frame-shiftENST00000374761ENST00000394140RAP1GAPchr1

21936613

-NIT2chr3

100073616

+
Frame-shiftENST00000374761ENST00000394140RAP1GAPchr1

21936067

-NIT2chr3

100073615

+
Frame-shiftENST00000374763ENST00000394140RAP1GAPchr1

21936068

-NIT2chr3

100073616

+
Frame-shiftENST00000374763ENST00000394140RAP1GAPchr1

21936613

-NIT2chr3

100073616

+
Frame-shiftENST00000374763ENST00000394140RAP1GAPchr1

21936067

-NIT2chr3

100073615

+
Frame-shiftENST00000374765ENST00000394140RAP1GAPchr1

21936068

-NIT2chr3

100073616

+
Frame-shiftENST00000374765ENST00000394140RAP1GAPchr1

21936613

-NIT2chr3

100073616

+
Frame-shiftENST00000374765ENST00000394140RAP1GAPchr1

21937945

-NIT2chr3

100073616

+
Frame-shiftENST00000374765ENST00000394140RAP1GAPchr1

21936067

-NIT2chr3

100073615

+
Frame-shiftENST00000542643ENST00000394140RAP1GAPchr1

21936068

-NIT2chr3

100073616

+
Frame-shiftENST00000542643ENST00000394140RAP1GAPchr1

21936613

-NIT2chr3

100073616

+
Frame-shiftENST00000542643ENST00000394140RAP1GAPchr1

21936067

-NIT2chr3

100073615

+
In-frameENST00000290101ENST00000394140RAP1GAPchr1

21937945

-NIT2chr3

100073616

+
In-frameENST00000374761ENST00000394140RAP1GAPchr1

21937945

-NIT2chr3

100073616

+
In-frameENST00000374763ENST00000394140RAP1GAPchr1

21937945

-NIT2chr3

100073616

+
In-frameENST00000542643ENST00000394140RAP1GAPchr1

21937945

-NIT2chr3

100073616

+
intron-3CDSENST00000374757ENST00000394140RAP1GAPchr1

21936068

-NIT2chr3

100073616

+
intron-3CDSENST00000374757ENST00000394140RAP1GAPchr1

21936613

-NIT2chr3

100073616

+
intron-3CDSENST00000374757ENST00000394140RAP1GAPchr1

21937945

-NIT2chr3

100073616

+
intron-3CDSENST00000374757ENST00000394140RAP1GAPchr1

21936067

-NIT2chr3

100073615

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374761RAP1GAPchr121937945-ENST00000394140NIT2chr3100073616+268293601010336
ENST00000290101RAP1GAPchr121937945-ENST00000394140NIT2chr3100073616+28141068331142369
ENST00000374763RAP1GAPchr121937945-ENST00000394140NIT2chr3100073616+25988529926305
ENST00000542643RAP1GAPchr121937945-ENST00000394140NIT2chr3100073616+289211462341220328

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374761ENST00000394140RAP1GAPchr121937945-NIT2chr3100073616+0.00128720.9987128
ENST00000290101ENST00000394140RAP1GAPchr121937945-NIT2chr3100073616+0.0010557470.9989442
ENST00000374763ENST00000394140RAP1GAPchr121937945-NIT2chr3100073616+0.0011956770.99880433
ENST00000542643ENST00000394140RAP1GAPchr121937945-NIT2chr3100073616+0.0014623010.99853766

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Fusion Genomic Features for RAP1GAP-NIT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RAP1GAPchr121936067-NIT2chr3100073615+0.0128444960.98715556
RAP1GAPchr121936067-NIT2chr3100073615+0.0128444960.98715556
RAP1GAPchr121937944-NIT2chr3100073615+0.0051478490.9948521
RAP1GAPchr121936612-NIT2chr3100073615+4.01E-050.99995995
RAP1GAPchr121936067-NIT2chr3100073615+0.0128444960.98715556
RAP1GAPchr121936067-NIT2chr3100073615+0.0128444960.98715556
RAP1GAPchr121937944-NIT2chr3100073615+0.0051478490.9948521
RAP1GAPchr121936612-NIT2chr3100073615+4.01E-050.99995995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RAP1GAP-NIT2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:21936068/chr3:100073616)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NIT2

Q9NQR4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Has omega-amidase activity (PubMed:22674578, PubMed:19595734). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19595734). {ECO:0000269|PubMed:19595734, ECO:0000269|PubMed:22674578}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAP1GAPchr1:21937945chr3:100073616ENST00000290101-13251_173451054.6666666666667DomainGoLoco
HgeneRAP1GAPchr1:21937945chr3:100073616ENST00000374765-13251_17281996.6666666666666DomainGoLoco
HgeneRAP1GAPchr1:21937945chr3:100073616ENST00000542643-14271_17281992.3333333333334DomainGoLoco

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAP1GAPchr1:21937945chr3:100073616ENST00000290101-1325181_3973451054.6666666666667DomainRap-GAP
HgeneRAP1GAPchr1:21937945chr3:100073616ENST00000374765-1325181_397281996.6666666666666DomainRap-GAP
HgeneRAP1GAPchr1:21937945chr3:100073616ENST00000542643-1427181_397281992.3333333333334DomainRap-GAP
TgeneNIT2chr1:21937945chr3:100073616ENST000003941407104_248227277.0DomainCN hydrolase


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Fusion Gene Sequence for RAP1GAP-NIT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72173_72173_1_RAP1GAP-NIT2_RAP1GAP_chr1_21937945_ENST00000290101_NIT2_chr3_100073616_ENST00000394140_length(transcript)=2814nt_BP=1068nt
GCGCGGGCCGGGCCGGGCGGCGGCGGCGGCACCATGAGCGGCCGGAAGCGCAGCTTCACCTTCGGGGCCTACGGCGGGGTGGACAAGTCC
TTCACTTCTCGCCGGAGTGTGTGGAGGAGCGATGGGCAGAACCAGCACTTCCCTCAGGCACTAGACCTGTCACGAGTGAACTTAGTTCCC
TCCTATACTCCTTCACTCTACCCTAAGAACACAGATCTATTTGAGATGATTGAGAAGATGCAGGGAAGCAGGATGGATGAACAACGCTGC
TCCTTCCCGCCGCCCCTCAAAACAGAGGAGGACTACATTCCATACCCGAGCGTGCACGAGGTCTTGGGGCGAGAAGGACCCTTCCCCCTC
ATCCTGCTGCCCCAGTTTGGGGGCTACTGGATTGAGGGCACCAACCACGAAATCACCAGCATCCCCGAGACAGAGCCACTGCAGTCGCCC
ACAACCAAGGTGAAGCTCGAGTGCAACCCCACAGCCCGCATCTACCGGAAGCACTTTCTCGGCAAGGAGCATTTCAATTACTACTCACTG
GACGCTGCCCTCGGCCACCTTGTCTTCTCACTCAAGTACGATGTCATCGGGGACCAAGAGCACCTGCGGCTGCTGCTCAGGACCAAGTGC
CGGACATACCATGATGTCATCCCCATCTCCTGCCTCACCGAGTTCCCTAATGTTGTCCAGATGGCAAAGTTGGTGTGTGAAGACGTCAAT
GTGGATCGGTTCTATCCTGTGCTCTACCCCAAGGCTTCCCGGCTCATCGTCACCTTTGACGAGCATGTCATCAGCAATAACTTCAAGTTT
GGCGTCATTTATCAGAAGCTTGGGCAGACCTCCGAGGAAGAACTCTTCAGCACCAATGAGGAAAGTCCCGCTTTCGTGGAGTTCCTTGAA
TTTCTTGGCCAGAAGGTCAAACTGCAGGACTTTAAGGGGTTCCGAGGAGGCCTGGACGTGACCCACGGGCAGACGGGGACCGAATCTGTG
TACTGCAACTTCCGCAACAAGGAGATCATGTTTCACGTGTCCACCAAGCTGCCATACACGGAAGGGGACGCCCAGCAGGGGGGAGGTTCT
AGCCAAAGCTGGCACAGAAGAAGCAATCGTGTATTCAGACATAGACCTGAAGAAGCTGGCTGAAATACGCCAGCAAATCCCCGTTTTTAG
ACAGAAGCGATCAGACCTCTATGCTGTGGAGATGAAAAAGCCCTAAAGTTTATGTTTCTAATGTGTCACAGAATAGGACGATATGATTCT
ACAACATAATCAACTCCCTATTAAATTCTTTAATGAAGATTTTTTTTTTAATTCGGCCTTGTCCTTCCTAGGTTCTCTATTGAGATGAGA
AAGCCTCATTATGCTGACATTTTCCACGCCACATTAAATAGTTAAAAAGGATGCAGCCTGGAGCCAGAGAGCAGAAAGCTGGGCTGGTTC
TGAAGCTTCTTCCATACTTAAGTTGCCTCCAAGCAGTTTGTGAAAGTATCAGATCTTGGTATCCTGGTGATTGATTCACCTAATATAAAT
ATATTTGTGTCATGAACCTCTTATCCCGTTGCTGGAGTTGTAATCTCCATCATCTAGAAAACGTGGTCTGGTGCTATTCTTTTCCAAGCA
GTACCTTGAAGTTCCATTTTTGGTTCATGAGTAGCTATAGAACGCAAGGTGATACATCTTTGGTGTTTGCCAGAGAAGTTGGCAGCCCCA
CCCCTCCTACCAGCCTTTGCACTCTTCAAATTTAAAAAGGAGCTACTTATCAACCCCAGGCCCTTCTGGTCTTAGAGGAAGGACTGGGCC
AACAAAGAGCACCATGGGAGAATGGCAGTGGTGGCATTTAGTGAAGACAATTTAGTATGAATGTCTGCAAAAGATTTTTTTGATAGCGTT
GAGTGTCTGAAAGTCCCATTATTTTTCTTTTTTCTTTTTCCCCAGTAACACTTTCTAGCTCCACGGATAAGGAATCACTGAACCTAGTAG
TTCTTAGACAGCTTGGTTTGAGAATCCTTTTGCGGTTAAAAATTAGGGACTGAGCCAGGCGCAGTAGCATGCGCCTGTAGTCCTAGCCAC
ATTGGAGGCTGAGGTAGGAGGATCCCTTGAGTCCACAAGTTTGAGTTCAGCCAGAGACCCTATCTCACTATATATATGTATCTCAAAGAC
TTCAATGGGTTTTTGCTTACATGGGCCAGTAATTGTTGAACAACCAGCTATTTGAGAAAAAGCCCTGATTTTGCTGCTTTTCATGGTGTA
AATACTTAACCATGGCTGAGTTTGAGCTATCTGCATGACACCTCTAAACACAGAGTTGGGAATAGATGTGCACAATCAGCTCTGGGGAGC
TGGTGCAATCCTGCCCTAGCACACCACTGGTTTAAGATAGATATATCATATAGATATTTACCATTTACCATATTGGAAAGTAAAATGGAG
AAAAATTTAAAACACAAGATACATGAGCACACATTCCATTAGCTATTAAGGTGATGGACACGGTGTCCAAATGACACGGTGTCATTTAAC
TTCTGGAAAACAACACTGTGTACTGAGAACAAGAGAAAGACAAATGACTTTTTTAAATTAAGTTTTTAATTTACAATTGATGCATAATTT
TACTTTAAAAAAATAAGTGTGCAATTTGGTAAACTTTGACATATACAGCTATAAACCACTCCAATCAAGATAACATATTTACCACCCCCA
ACAGTTTCCATGTGCTGTATTATAATCCCTCTGGCTAGTCCTTTGTCAATCACTGATAAATTTTATTACTATAGATTAGCTTGCATTTTC

>72173_72173_1_RAP1GAP-NIT2_RAP1GAP_chr1_21937945_ENST00000290101_NIT2_chr3_100073616_ENST00000394140_length(amino acids)=369AA_BP=344
MSGRKRSFTFGAYGGVDKSFTSRRSVWRSDGQNQHFPQALDLSRVNLVPSYTPSLYPKNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEED
YIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSL
KYDVIGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTS
EEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQGGGSSQSWHRRSNRV

--------------------------------------------------------------
>72173_72173_2_RAP1GAP-NIT2_RAP1GAP_chr1_21937945_ENST00000374761_NIT2_chr3_100073616_ENST00000394140_length(transcript)=2682nt_BP=936nt
ATGGCACAGCTGCGGCCCGCGGTGCCACCCGGCCGTCCGCGGAGGGGCTCGCTGCCCGCGGGGGCCAGCTGGCAGAACACAGATCTATTT
GAGATGATTGAGAAGATGCAGGGAAGCAGGATGGATGAACAACGCTGCTCCTTCCCGCCGCCCCTCAAAACAGAGGAGGACTACATTCCA
TACCCGAGCGTGCACGAGGTCTTGGGGCGAGAAGGACCCTTCCCCCTCATCCTGCTGCCCCAGTTTGGGGGCTACTGGATTGAGGGCACC
AACCACGAAATCACCAGCATCCCCGAGACAGAGCCACTGCAGTCGCCCACAACCAAGGTGAAGCTCGAGTGCAACCCCACAGCCCGCATC
TACCGGAAGCACTTTCTCGGCAAGGAGCATTTCAATTACTACTCACTGGACGCTGCCCTCGGCCACCTTGTCTTCTCACTCAAGTACGAT
GTCATCGGGGACCAAGAGCACCTGCGGCTGCTGCTCAGGACCAAGTGCCGGACATACCATGATGTCATCCCCATCTCCTGCCTCACCGAG
TTCCCTAATGTTGTCCAGATGGCAAAGTTGGTGTGTGAAGACGTCAATGTGGATCGGTTCTATCCTGTGCTCTACCCCAAGGCTTCCCGG
CTCATCGTCACCTTTGACGAGCATGTCATCAGCAATAACTTCAAGTTTGGCGTCATTTATCAGAAGCTTGGGCAGACCTCCGAGGAAGAA
CTCTTCAGCACCAATGAGGAAAGTCCCGCTTTCGTGGAGTTCCTTGAATTTCTTGGCCAGAAGGTCAAACTGCAGGACTTTAAGGGGTTC
CGAGGAGGCCTGGACGTGACCCACGGGCAGACGGGGACCGAATCTGTGTACTGCAACTTCCGCAACAAGGAGATCATGTTTCACGTGTCC
ACCAAGCTGCCATACACGGAAGGGGACGCCCAGCAGGGGGGAGGTTCTAGCCAAAGCTGGCACAGAAGAAGCAATCGTGTATTCAGACAT
AGACCTGAAGAAGCTGGCTGAAATACGCCAGCAAATCCCCGTTTTTAGACAGAAGCGATCAGACCTCTATGCTGTGGAGATGAAAAAGCC
CTAAAGTTTATGTTTCTAATGTGTCACAGAATAGGACGATATGATTCTACAACATAATCAACTCCCTATTAAATTCTTTAATGAAGATTT
TTTTTTTAATTCGGCCTTGTCCTTCCTAGGTTCTCTATTGAGATGAGAAAGCCTCATTATGCTGACATTTTCCACGCCACATTAAATAGT
TAAAAAGGATGCAGCCTGGAGCCAGAGAGCAGAAAGCTGGGCTGGTTCTGAAGCTTCTTCCATACTTAAGTTGCCTCCAAGCAGTTTGTG
AAAGTATCAGATCTTGGTATCCTGGTGATTGATTCACCTAATATAAATATATTTGTGTCATGAACCTCTTATCCCGTTGCTGGAGTTGTA
ATCTCCATCATCTAGAAAACGTGGTCTGGTGCTATTCTTTTCCAAGCAGTACCTTGAAGTTCCATTTTTGGTTCATGAGTAGCTATAGAA
CGCAAGGTGATACATCTTTGGTGTTTGCCAGAGAAGTTGGCAGCCCCACCCCTCCTACCAGCCTTTGCACTCTTCAAATTTAAAAAGGAG
CTACTTATCAACCCCAGGCCCTTCTGGTCTTAGAGGAAGGACTGGGCCAACAAAGAGCACCATGGGAGAATGGCAGTGGTGGCATTTAGT
GAAGACAATTTAGTATGAATGTCTGCAAAAGATTTTTTTGATAGCGTTGAGTGTCTGAAAGTCCCATTATTTTTCTTTTTTCTTTTTCCC
CAGTAACACTTTCTAGCTCCACGGATAAGGAATCACTGAACCTAGTAGTTCTTAGACAGCTTGGTTTGAGAATCCTTTTGCGGTTAAAAA
TTAGGGACTGAGCCAGGCGCAGTAGCATGCGCCTGTAGTCCTAGCCACATTGGAGGCTGAGGTAGGAGGATCCCTTGAGTCCACAAGTTT
GAGTTCAGCCAGAGACCCTATCTCACTATATATATGTATCTCAAAGACTTCAATGGGTTTTTGCTTACATGGGCCAGTAATTGTTGAACA
ACCAGCTATTTGAGAAAAAGCCCTGATTTTGCTGCTTTTCATGGTGTAAATACTTAACCATGGCTGAGTTTGAGCTATCTGCATGACACC
TCTAAACACAGAGTTGGGAATAGATGTGCACAATCAGCTCTGGGGAGCTGGTGCAATCCTGCCCTAGCACACCACTGGTTTAAGATAGAT
ATATCATATAGATATTTACCATTTACCATATTGGAAAGTAAAATGGAGAAAAATTTAAAACACAAGATACATGAGCACACATTCCATTAG
CTATTAAGGTGATGGACACGGTGTCCAAATGACACGGTGTCATTTAACTTCTGGAAAACAACACTGTGTACTGAGAACAAGAGAAAGACA
AATGACTTTTTTAAATTAAGTTTTTAATTTACAATTGATGCATAATTTTACTTTAAAAAAATAAGTGTGCAATTTGGTAAACTTTGACAT
ATACAGCTATAAACCACTCCAATCAAGATAACATATTTACCACCCCCAACAGTTTCCATGTGCTGTATTATAATCCCTCTGGCTAGTCCT

>72173_72173_2_RAP1GAP-NIT2_RAP1GAP_chr1_21937945_ENST00000374761_NIT2_chr3_100073616_ENST00000394140_length(amino acids)=336AA_BP=311
MAQLRPAVPPGRPRRGSLPAGASWQNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGT
NHEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVIGDQEHLRLLLRTKCRTYHDVIPISCLTE
FPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGF

--------------------------------------------------------------
>72173_72173_3_RAP1GAP-NIT2_RAP1GAP_chr1_21937945_ENST00000374763_NIT2_chr3_100073616_ENST00000394140_length(transcript)=2598nt_BP=852nt
CTATTTGAGATGATTGAGAAGATGCAGGGAAGCAGGATGGATGAACAACGCTGCTCCTTCCCGCCGCCCCTCAAAACAGAGGAGGACTAC
ATTCCATACCCGAGCGTGCACGAGGTCTTGGGGCGAGAAGGACCCTTCCCCCTCATCCTGCTGCCCCAGTTTGGGGGCTACTGGATTGAG
GGCACCAACCACGAAATCACCAGCATCCCCGAGACAGAGCCACTGCAGTCGCCCACAACCAAGGTGAAGCTCGAGTGCAACCCCACAGCC
CGCATCTACCGGAAGCACTTTCTCGGCAAGGAGCATTTCAATTACTACTCACTGGACGCTGCCCTCGGCCACCTTGTCTTCTCACTCAAG
TACGATGTCATCGGGGACCAAGAGCACCTGCGGCTGCTGCTCAGGACCAAGTGCCGGACATACCATGATGTCATCCCCATCTCCTGCCTC
ACCGAGTTCCCTAATGTTGTCCAGATGGCAAAGTTGGTGTGTGAAGACGTCAATGTGGATCGGTTCTATCCTGTGCTCTACCCCAAGGCT
TCCCGGCTCATCGTCACCTTTGACGAGCATGTCATCAGCAATAACTTCAAGTTTGGCGTCATTTATCAGAAGCTTGGGCAGACCTCCGAG
GAAGAACTCTTCAGCACCAATGAGGAAAGTCCCGCTTTCGTGGAGTTCCTTGAATTTCTTGGCCAGAAGGTCAAACTGCAGGACTTTAAG
GGGTTCCGAGGAGGCCTGGACGTGACCCACGGGCAGACGGGGACCGAATCTGTGTACTGCAACTTCCGCAACAAGGAGATCATGTTTCAC
GTGTCCACCAAGCTGCCATACACGGAAGGGGACGCCCAGCAGGGGGGAGGTTCTAGCCAAAGCTGGCACAGAAGAAGCAATCGTGTATTC
AGACATAGACCTGAAGAAGCTGGCTGAAATACGCCAGCAAATCCCCGTTTTTAGACAGAAGCGATCAGACCTCTATGCTGTGGAGATGAA
AAAGCCCTAAAGTTTATGTTTCTAATGTGTCACAGAATAGGACGATATGATTCTACAACATAATCAACTCCCTATTAAATTCTTTAATGA
AGATTTTTTTTTTAATTCGGCCTTGTCCTTCCTAGGTTCTCTATTGAGATGAGAAAGCCTCATTATGCTGACATTTTCCACGCCACATTA
AATAGTTAAAAAGGATGCAGCCTGGAGCCAGAGAGCAGAAAGCTGGGCTGGTTCTGAAGCTTCTTCCATACTTAAGTTGCCTCCAAGCAG
TTTGTGAAAGTATCAGATCTTGGTATCCTGGTGATTGATTCACCTAATATAAATATATTTGTGTCATGAACCTCTTATCCCGTTGCTGGA
GTTGTAATCTCCATCATCTAGAAAACGTGGTCTGGTGCTATTCTTTTCCAAGCAGTACCTTGAAGTTCCATTTTTGGTTCATGAGTAGCT
ATAGAACGCAAGGTGATACATCTTTGGTGTTTGCCAGAGAAGTTGGCAGCCCCACCCCTCCTACCAGCCTTTGCACTCTTCAAATTTAAA
AAGGAGCTACTTATCAACCCCAGGCCCTTCTGGTCTTAGAGGAAGGACTGGGCCAACAAAGAGCACCATGGGAGAATGGCAGTGGTGGCA
TTTAGTGAAGACAATTTAGTATGAATGTCTGCAAAAGATTTTTTTGATAGCGTTGAGTGTCTGAAAGTCCCATTATTTTTCTTTTTTCTT
TTTCCCCAGTAACACTTTCTAGCTCCACGGATAAGGAATCACTGAACCTAGTAGTTCTTAGACAGCTTGGTTTGAGAATCCTTTTGCGGT
TAAAAATTAGGGACTGAGCCAGGCGCAGTAGCATGCGCCTGTAGTCCTAGCCACATTGGAGGCTGAGGTAGGAGGATCCCTTGAGTCCAC
AAGTTTGAGTTCAGCCAGAGACCCTATCTCACTATATATATGTATCTCAAAGACTTCAATGGGTTTTTGCTTACATGGGCCAGTAATTGT
TGAACAACCAGCTATTTGAGAAAAAGCCCTGATTTTGCTGCTTTTCATGGTGTAAATACTTAACCATGGCTGAGTTTGAGCTATCTGCAT
GACACCTCTAAACACAGAGTTGGGAATAGATGTGCACAATCAGCTCTGGGGAGCTGGTGCAATCCTGCCCTAGCACACCACTGGTTTAAG
ATAGATATATCATATAGATATTTACCATTTACCATATTGGAAAGTAAAATGGAGAAAAATTTAAAACACAAGATACATGAGCACACATTC
CATTAGCTATTAAGGTGATGGACACGGTGTCCAAATGACACGGTGTCATTTAACTTCTGGAAAACAACACTGTGTACTGAGAACAAGAGA
AAGACAAATGACTTTTTTAAATTAAGTTTTTAATTTACAATTGATGCATAATTTTACTTTAAAAAAATAAGTGTGCAATTTGGTAAACTT
TGACATATACAGCTATAAACCACTCCAATCAAGATAACATATTTACCACCCCCAACAGTTTCCATGTGCTGTATTATAATCCCTCTGGCT

>72173_72173_3_RAP1GAP-NIT2_RAP1GAP_chr1_21937945_ENST00000374763_NIT2_chr3_100073616_ENST00000394140_length(amino acids)=305AA_BP=280
MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEITSIPETEPLQSPTTKVKLECNPTARIY
RKHFLGKEHFNYYSLDAALGHLVFSLKYDVIGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL
IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVST

--------------------------------------------------------------
>72173_72173_4_RAP1GAP-NIT2_RAP1GAP_chr1_21937945_ENST00000542643_NIT2_chr3_100073616_ENST00000394140_length(transcript)=2892nt_BP=1146nt
CGGGCACCAGAGTGCCGAGCCCAGGACGCCCCCGGCCCAGGCCCTTGGGTTAATACCTCTGCCAACCGAGGCCACCCTCCCTCGGACCCC
CATTCGGAGGAAGCAGACCCAAGTTCGAATTCTGACATTGCCACTGAGCAGCCGTACAACTTTTGGGTGGACAAGTCCTTCACTTCTCGC
CGGAGTGTGTGGAGGAGCGATGGGCAGAACCAGCACTTCCCTCAGGCACTAGACCTGTCACGAGTGAACTTAGTTCCCTCCTATACTCCT
TCACTCTACCCTAAGAACACAGATCTATTTGAGATGATTGAGAAGATGCAGGGAAGCAGGATGGATGAACAACGCTGCTCCTTCCCGCCG
CCCCTCAAAACAGAGGAGGACTACATTCCATACCCGAGCGTGCACGAGGTCTTGGGGCGAGAAGGACCCTTCCCCCTCATCCTGCTGCCC
CAGTTTGGGGGCTACTGGATTGAGGGCACCAACCACGAAATCACCAGCATCCCCGAGACAGAGCCACTGCAGTCGCCCACAACCAAGGTG
AAGCTCGAGTGCAACCCCACAGCCCGCATCTACCGGAAGCACTTTCTCGGCAAGGAGCATTTCAATTACTACTCACTGGACGCTGCCCTC
GGCCACCTTGTCTTCTCACTCAAGTACGATGTCATCGGGGACCAAGAGCACCTGCGGCTGCTGCTCAGGACCAAGTGCCGGACATACCAT
GATGTCATCCCCATCTCCTGCCTCACCGAGTTCCCTAATGTTGTCCAGATGGCAAAGTTGGTGTGTGAAGACGTCAATGTGGATCGGTTC
TATCCTGTGCTCTACCCCAAGGCTTCCCGGCTCATCGTCACCTTTGACGAGCATGTCATCAGCAATAACTTCAAGTTTGGCGTCATTTAT
CAGAAGCTTGGGCAGACCTCCGAGGAAGAACTCTTCAGCACCAATGAGGAAAGTCCCGCTTTCGTGGAGTTCCTTGAATTTCTTGGCCAG
AAGGTCAAACTGCAGGACTTTAAGGGGTTCCGAGGAGGCCTGGACGTGACCCACGGGCAGACGGGGACCGAATCTGTGTACTGCAACTTC
CGCAACAAGGAGATCATGTTTCACGTGTCCACCAAGCTGCCATACACGGAAGGGGACGCCCAGCAGGGGGGAGGTTCTAGCCAAAGCTGG
CACAGAAGAAGCAATCGTGTATTCAGACATAGACCTGAAGAAGCTGGCTGAAATACGCCAGCAAATCCCCGTTTTTAGACAGAAGCGATC
AGACCTCTATGCTGTGGAGATGAAAAAGCCCTAAAGTTTATGTTTCTAATGTGTCACAGAATAGGACGATATGATTCTACAACATAATCA
ACTCCCTATTAAATTCTTTAATGAAGATTTTTTTTTTAATTCGGCCTTGTCCTTCCTAGGTTCTCTATTGAGATGAGAAAGCCTCATTAT
GCTGACATTTTCCACGCCACATTAAATAGTTAAAAAGGATGCAGCCTGGAGCCAGAGAGCAGAAAGCTGGGCTGGTTCTGAAGCTTCTTC
CATACTTAAGTTGCCTCCAAGCAGTTTGTGAAAGTATCAGATCTTGGTATCCTGGTGATTGATTCACCTAATATAAATATATTTGTGTCA
TGAACCTCTTATCCCGTTGCTGGAGTTGTAATCTCCATCATCTAGAAAACGTGGTCTGGTGCTATTCTTTTCCAAGCAGTACCTTGAAGT
TCCATTTTTGGTTCATGAGTAGCTATAGAACGCAAGGTGATACATCTTTGGTGTTTGCCAGAGAAGTTGGCAGCCCCACCCCTCCTACCA
GCCTTTGCACTCTTCAAATTTAAAAAGGAGCTACTTATCAACCCCAGGCCCTTCTGGTCTTAGAGGAAGGACTGGGCCAACAAAGAGCAC
CATGGGAGAATGGCAGTGGTGGCATTTAGTGAAGACAATTTAGTATGAATGTCTGCAAAAGATTTTTTTGATAGCGTTGAGTGTCTGAAA
GTCCCATTATTTTTCTTTTTTCTTTTTCCCCAGTAACACTTTCTAGCTCCACGGATAAGGAATCACTGAACCTAGTAGTTCTTAGACAGC
TTGGTTTGAGAATCCTTTTGCGGTTAAAAATTAGGGACTGAGCCAGGCGCAGTAGCATGCGCCTGTAGTCCTAGCCACATTGGAGGCTGA
GGTAGGAGGATCCCTTGAGTCCACAAGTTTGAGTTCAGCCAGAGACCCTATCTCACTATATATATGTATCTCAAAGACTTCAATGGGTTT
TTGCTTACATGGGCCAGTAATTGTTGAACAACCAGCTATTTGAGAAAAAGCCCTGATTTTGCTGCTTTTCATGGTGTAAATACTTAACCA
TGGCTGAGTTTGAGCTATCTGCATGACACCTCTAAACACAGAGTTGGGAATAGATGTGCACAATCAGCTCTGGGGAGCTGGTGCAATCCT
GCCCTAGCACACCACTGGTTTAAGATAGATATATCATATAGATATTTACCATTTACCATATTGGAAAGTAAAATGGAGAAAAATTTAAAA
CACAAGATACATGAGCACACATTCCATTAGCTATTAAGGTGATGGACACGGTGTCCAAATGACACGGTGTCATTTAACTTCTGGAAAACA
ACACTGTGTACTGAGAACAAGAGAAAGACAAATGACTTTTTTAAATTAAGTTTTTAATTTACAATTGATGCATAATTTTACTTTAAAAAA
ATAAGTGTGCAATTTGGTAAACTTTGACATATACAGCTATAAACCACTCCAATCAAGATAACATATTTACCACCCCCAACAGTTTCCATG
TGCTGTATTATAATCCCTCTGGCTAGTCCTTTGTCAATCACTGATAAATTTTATTACTATAGATTAGCTTGCATTTTCTAAAATTATATA

>72173_72173_4_RAP1GAP-NIT2_RAP1GAP_chr1_21937945_ENST00000542643_NIT2_chr3_100073616_ENST00000394140_length(amino acids)=328AA_BP=303
MSRVNLVPSYTPSLYPKNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEITSIP
ETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVIGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMA
KLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RAP1GAP-NIT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAP1GAP-NIT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAP1GAP-NIT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource