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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ASPH-TACC1 (FusionGDB2 ID:7220)

Fusion Gene Summary for ASPH-TACC1

Fusion gene summary

Fusion gene information	Fusion gene name: ASPH-TACC1
	Fusion gene ID: 7220
		Hgene	Tgene
	Gene symbol	ASPH	TACC1
	Gene ID	444	6867
	Gene name	aspartate beta-hydroxylase	transforming acidic coiled-coil containing protein 1
	Synonyms	AAH\|BAH\|CASQ2BP1\|FDLAB\|HAAH\|JCTN\|junctin	Ga55
	Cytomap	8q12.3	8p11.22
	Type of gene	protein-coding	protein-coding
	Description	aspartyl/asparaginyl beta-hydroxylaseA beta H-J-JASP beta-hydroxylasecardiac junctinhumbugjunctatepeptide-aspartate beta-dioxygenase	transforming acidic coiled-coil-containing protein 1gastric cancer antigen Ga55taxin-1
	Modification date	20200315	20200320
	UniProtAcc	Q12797	O75410
	Ensembl transtripts involved in fusion gene	ENST00000379454, ENST00000522919, ENST00000541428, ENST00000523897, ENST00000356457, ENST00000379449, ENST00000389204, ENST00000445642, ENST00000517661, ENST00000517847, ENST00000517856, ENST00000517903, ENST00000518068, ENST00000522603, ENST00000522835,	ENST00000443286, ENST00000518415, ENST00000520340, ENST00000276520, ENST00000317827, ENST00000330691, ENST00000348567, ENST00000379931, ENST00000519416, ENST00000520611, ENST00000520615, ENST00000520973, ENST00000522752,
Fusion gene scores	* DoF score	20 X 16 X 7=2240	18 X 21 X 10=3780
	# samples	21	23
	** MAII score	log2(21/2240*10)=-3.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/3780*10)=-4.03868046816406 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ASPH [Title/Abstract] AND TACC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ASPH(62531537)-TACC1(38599869), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ASPH	GO:0045862	positive regulation of proteolysis	18387192
Hgene	ASPH	GO:0097202	activation of cysteine-type endopeptidase activity	18387192

Fusion gene breakpoints across ASPH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TACC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-YC-A89H-01A	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+

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Fusion Gene ORF analysis for ASPH-TACC1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000379454	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000379454	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000379454	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000522919	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000522919	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000522919	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000541428	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000541428	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-5UTR	ENST00000541428	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000379454	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000522919	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5CDS-intron	ENST00000541428	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-5UTR	ENST00000523897	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-5UTR	ENST00000523897	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-5UTR	ENST00000523897	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
5UTR-intron	ENST00000523897	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000356457	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000356457	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000356457	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000379449	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000379449	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000379449	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000389204	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000389204	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000389204	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000445642	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000445642	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000445642	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517661	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517661	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517661	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517847	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517847	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517847	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517856	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517856	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517856	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517903	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517903	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000517903	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000518068	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000518068	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000518068	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000522603	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000522603	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000522603	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000522835	ENST00000443286	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000522835	ENST00000518415	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-5UTR	ENST00000522835	ENST00000520340	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000356457	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000379449	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000389204	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000445642	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517661	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517847	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517856	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000517903	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000518068	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522603	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000276520	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000317827	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000330691	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000348567	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000379931	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000519416	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000520611	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000520615	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000520973	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+
intron-intron	ENST00000522835	ENST00000522752	ASPH	chr8	62531537	-	TACC1	chr8	38599869	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ASPH-TACC1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ASPH	chr8	62531536	-	TACC1	chr8	38599868	+	2.21E-05	0.99997795
ASPH	chr8	62531536	-	TACC1	chr8	38599868	+	2.21E-05	0.99997795

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ASPH-TACC1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:62531537/:38599869)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ASPH Q12797	TACC1 O75410
FUNCTION: [Isoform 1]: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. {ECO:0000269\|PubMed:11773073}.; FUNCTION: [Isoform 8]: membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. {ECO:0000269\|PubMed:22586105}.	FUNCTION: Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269\|PubMed:20078863}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ASPH-TACC1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ASPH-TACC1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ASPH-TACC1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ASPH-TACC1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source