FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:RAPGEF1-MCU (FusionGDB2 ID:72212)

Fusion Gene Summary for RAPGEF1-MCU

check button Fusion gene summary
Fusion gene informationFusion gene name: RAPGEF1-MCU
Fusion gene ID: 72212
HgeneTgene
Gene symbol

RAPGEF1

MCU

Gene ID

2889

90550

Gene nameRap guanine nucleotide exchange factor 1mitochondrial calcium uniporter
SynonymsC3G|GRF2C10orf42|CCDC109A|HsMCU
Cytomap

9q34.13

10q22.1

Type of geneprotein-codingprotein-coding
Descriptionrap guanine nucleotide exchange factor 1CRK SH3-binding GNRPRap guanine nucleotide exchange factor (GEF) 1guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)calcium uniporter protein, mitochondrialcoiled-coil domain-containing protein 109A
Modification date2020032720200313
UniProtAcc.

Q96AQ8

Ensembl transtripts involved in fusion geneENST00000372195, ENST00000372189, 
ENST00000372190, ENST00000481260, 
ENST00000605416, ENST00000357157, 
ENST00000373053, ENST00000536019, 
Fusion gene scores* DoF score20 X 16 X 11=35207 X 5 X 5=175
# samples 237
** MAII scorelog2(23/3520*10)=-3.93586966258028
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAPGEF1 [Title/Abstract] AND MCU [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAPGEF1(134615157)-MCU(74594117), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAPGEF1

GO:0038180

nerve growth factor signaling pathway

17724123

HgeneRAPGEF1

GO:0043547

positive regulation of GTPase activity

10548487

HgeneRAPGEF1

GO:0071320

cellular response to cAMP

21840392

HgeneRAPGEF1

GO:1990090

cellular response to nerve growth factor stimulus

17724123

TgeneMCU

GO:0006851

mitochondrial calcium ion transmembrane transport

21685888|24560927

TgeneMCU

GO:0019722

calcium-mediated signaling

21685886|21685888

TgeneMCU

GO:0036444

calcium import into the mitochondrion

22925203

TgeneMCU

GO:0051259

protein complex oligomerization

21685886

TgeneMCU

GO:0051561

positive regulation of mitochondrial calcium ion concentration

21685888|24560927


check buttonFusion gene breakpoints across RAPGEF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MCU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-58-8386-01ARAPGEF1chr9

134615157

-MCUchr10

74594117

+


Top

Fusion Gene ORF analysis for RAPGEF1-MCU

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000372195ENST00000605416RAPGEF1chr9

134615157

-MCUchr10

74594117

+
In-frameENST00000372195ENST00000357157RAPGEF1chr9

134615157

-MCUchr10

74594117

+
In-frameENST00000372195ENST00000373053RAPGEF1chr9

134615157

-MCUchr10

74594117

+
In-frameENST00000372195ENST00000536019RAPGEF1chr9

134615157

-MCUchr10

74594117

+
intron-3CDSENST00000372189ENST00000357157RAPGEF1chr9

134615157

-MCUchr10

74594117

+
intron-3CDSENST00000372189ENST00000373053RAPGEF1chr9

134615157

-MCUchr10

74594117

+
intron-3CDSENST00000372189ENST00000536019RAPGEF1chr9

134615157

-MCUchr10

74594117

+
intron-3CDSENST00000372190ENST00000357157RAPGEF1chr9

134615157

-MCUchr10

74594117

+
intron-3CDSENST00000372190ENST00000373053RAPGEF1chr9

134615157

-MCUchr10

74594117

+
intron-3CDSENST00000372190ENST00000536019RAPGEF1chr9

134615157

-MCUchr10

74594117

+
intron-3CDSENST00000481260ENST00000357157RAPGEF1chr9

134615157

-MCUchr10

74594117

+
intron-3CDSENST00000481260ENST00000373053RAPGEF1chr9

134615157

-MCUchr10

74594117

+
intron-3CDSENST00000481260ENST00000536019RAPGEF1chr9

134615157

-MCUchr10

74594117

+
intron-intronENST00000372189ENST00000605416RAPGEF1chr9

134615157

-MCUchr10

74594117

+
intron-intronENST00000372190ENST00000605416RAPGEF1chr9

134615157

-MCUchr10

74594117

+
intron-intronENST00000481260ENST00000605416RAPGEF1chr9

134615157

-MCUchr10

74594117

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372195RAPGEF1chr9134615157-ENST00000373053MCUchr1074594117+30833053351210291
ENST00000372195RAPGEF1chr9134615157-ENST00000357157MCUchr1074594117+30203053351147270
ENST00000372195RAPGEF1chr9134615157-ENST00000536019MCUchr1074594117+30813053351210291

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372195ENST00000373053RAPGEF1chr9134615157-MCUchr1074594117+0.0034989620.9965011
ENST00000372195ENST00000357157RAPGEF1chr9134615157-MCUchr1074594117+0.0014741890.9985258
ENST00000372195ENST00000536019RAPGEF1chr9134615157-MCUchr1074594117+0.0031099440.9968901

Top

Fusion Genomic Features for RAPGEF1-MCU


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RAPGEF1chr9134615156-MCUchr1074594116+8.85E-080.9999999
RAPGEF1chr9134615156-MCUchr1074594116+8.85E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for RAPGEF1-MCU


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:134615157/chr10:74594117)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MCU

Q96AQ8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564). Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU (PubMed:23178883). Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846). {ECO:0000269|PubMed:23178883, ECO:0000269|PubMed:26445506, ECO:0000269|PubMed:26976564, ECO:0000269|PubMed:27184846}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMCUchr9:134615157chr10:74594117ENST0000035715708192_22350331.0Coiled coilOntology_term=ECO:0000255
TgeneMCUchr9:134615157chr10:74594117ENST0000035715708311_33950331.0Coiled coilOntology_term=ECO:0000255
TgeneMCUchr9:134615157chr10:74594117ENST0000037305308192_22350352.0Coiled coilOntology_term=ECO:0000255
TgeneMCUchr9:134615157chr10:74594117ENST0000037305308311_33950352.0Coiled coilOntology_term=ECO:0000255
TgeneMCUchr9:134615157chr10:74594117ENST0000053601908192_2231303.0Coiled coilOntology_term=ECO:0000255
TgeneMCUchr9:134615157chr10:74594117ENST0000053601908311_3391303.0Coiled coilOntology_term=ECO:0000255
TgeneMCUchr9:134615157chr10:74594117ENST0000035715708216_23450331.0RegionOuter juxtamembrane helix (OJMH)
TgeneMCUchr9:134615157chr10:74594117ENST0000035715708283_29250331.0RegionInner juxtamembrane helix (IJMH)
TgeneMCUchr9:134615157chr10:74594117ENST000003571570875_16550331.0RegionN-terminal MCU domain
TgeneMCUchr9:134615157chr10:74594117ENST0000037305308216_23450352.0RegionOuter juxtamembrane helix (OJMH)
TgeneMCUchr9:134615157chr10:74594117ENST0000037305308283_29250352.0RegionInner juxtamembrane helix (IJMH)
TgeneMCUchr9:134615157chr10:74594117ENST000003730530875_16550352.0RegionN-terminal MCU domain
TgeneMCUchr9:134615157chr10:74594117ENST0000053601908216_2341303.0RegionOuter juxtamembrane helix (OJMH)
TgeneMCUchr9:134615157chr10:74594117ENST0000053601908283_2921303.0RegionInner juxtamembrane helix (IJMH)
TgeneMCUchr9:134615157chr10:74594117ENST000005360190875_1651303.0RegionN-terminal MCU domain
TgeneMCUchr9:134615157chr10:74594117ENST0000035715708257_26550331.0Topological domainMitochondrial intermembrane
TgeneMCUchr9:134615157chr10:74594117ENST0000035715708284_35150331.0Topological domainMitochondrial matrix
TgeneMCUchr9:134615157chr10:74594117ENST000003571570851_23350331.0Topological domainMitochondrial matrix
TgeneMCUchr9:134615157chr10:74594117ENST0000037305308257_26550352.0Topological domainMitochondrial intermembrane
TgeneMCUchr9:134615157chr10:74594117ENST0000037305308284_35150352.0Topological domainMitochondrial matrix
TgeneMCUchr9:134615157chr10:74594117ENST000003730530851_23350352.0Topological domainMitochondrial matrix
TgeneMCUchr9:134615157chr10:74594117ENST0000053601908257_2651303.0Topological domainMitochondrial intermembrane
TgeneMCUchr9:134615157chr10:74594117ENST0000053601908284_3511303.0Topological domainMitochondrial matrix
TgeneMCUchr9:134615157chr10:74594117ENST000005360190851_2331303.0Topological domainMitochondrial matrix
TgeneMCUchr9:134615157chr10:74594117ENST0000035715708234_25650331.0TransmembraneHelical
TgeneMCUchr9:134615157chr10:74594117ENST0000035715708266_28350331.0TransmembraneHelical
TgeneMCUchr9:134615157chr10:74594117ENST0000037305308234_25650352.0TransmembraneHelical
TgeneMCUchr9:134615157chr10:74594117ENST0000037305308266_28350352.0TransmembraneHelical
TgeneMCUchr9:134615157chr10:74594117ENST0000053601908234_2561303.0TransmembraneHelical
TgeneMCUchr9:134615157chr10:74594117ENST0000053601908266_2831303.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAPGEF1chr9:134615157chr10:74594117ENST00000372189-124963_96601078.0Compositional biasNote=Poly-Ser
HgeneRAPGEF1chr9:134615157chr10:74594117ENST00000372190-124963_96601096.0Compositional biasNote=Poly-Ser
HgeneRAPGEF1chr9:134615157chr10:74594117ENST00000372189-124688_81001078.0DomainN-terminal Ras-GEF
HgeneRAPGEF1chr9:134615157chr10:74594117ENST00000372189-124840_106401078.0DomainRas-GEF
HgeneRAPGEF1chr9:134615157chr10:74594117ENST00000372190-124688_81001096.0DomainN-terminal Ras-GEF
HgeneRAPGEF1chr9:134615157chr10:74594117ENST00000372190-124840_106401096.0DomainRas-GEF
HgeneRAPGEF1chr9:134615157chr10:74594117ENST00000372189-124281_29201078.0MotifNote=SH3-binding
HgeneRAPGEF1chr9:134615157chr10:74594117ENST00000372189-124451_46201078.0MotifNote=SH3-binding
HgeneRAPGEF1chr9:134615157chr10:74594117ENST00000372189-124538_54901078.0MotifNote=SH3-binding
HgeneRAPGEF1chr9:134615157chr10:74594117ENST00000372189-124606_61701078.0MotifNote=SH3-binding
HgeneRAPGEF1chr9:134615157chr10:74594117ENST00000372190-124281_29201096.0MotifNote=SH3-binding
HgeneRAPGEF1chr9:134615157chr10:74594117ENST00000372190-124451_46201096.0MotifNote=SH3-binding
HgeneRAPGEF1chr9:134615157chr10:74594117ENST00000372190-124538_54901096.0MotifNote=SH3-binding
HgeneRAPGEF1chr9:134615157chr10:74594117ENST00000372190-124606_61701096.0MotifNote=SH3-binding


Top

Fusion Gene Sequence for RAPGEF1-MCU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72212_72212_1_RAPGEF1-MCU_RAPGEF1_chr9_134615157_ENST00000372195_MCU_chr10_74594117_ENST00000357157_length(transcript)=3020nt_BP=305nt
CGCTGCGCTGCGGCCGGCTCGCGGGCCGGGGGAGCGGCGGCGGGCGCGCGGGAGGCGGAGCGGCGGCGGCGGGCGCGGCGGGAGCGGCTG
GGCCCGGGCGGGCTGGAGCGCGGTCGCCGAGCGCAGGGCCGCGGCCGCGCGGAGCCCGCCATGCCGGCGCGGGTCTGAGGCGTGGCGAGC
CAGGGCCGAGGCGAGCGGCGGGCGCGCCGCCCCTGTCGCCCCGCGGCGGCCCGGCCCGGGCCCGATGAGCGGCGGCCTCGGCCTCCGGCG
CAGCCCGGAAATGTCCGGCAAGATCGAGAAAGCAGGTACACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTG
TTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAATGGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGT
TCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTTTTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATT
CACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATAGACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACC
ACGTACGACCACCAAAAAGAGTAGAGATGGGGTTTTGCCATGTTGGCCAGAATGGTTTTGAACTCCTGACCTCAAGTTATCTACCTGCCT
CAGCCTCCCAAAGTGCCGAGATTATAGCCGTACGAATTGAGATTAGCAGAAAAGCTGAGAAGAGGACCACTTTGGTGCTATGGGGTGGCC
TTGCCTACATGGCCACACAGTTTGGCATTTTGGCCCGGCTTACCTGGTGGGAATATTCCTGGGACATCATGGAGCCAGTAACATACTTCA
TCACTTATGGAAGTGCCATGGCAATGTATGCATATTTTGTAATGACACGCCAGGAATATGTTTATCCAGAAGCCAGAGACAGACAATACT
TACTATTTTTCCATAAAGGAGCCAAAAAGTCACGTTTTGACCTAGAGAAATACAATCAACTCAAGGATGCAATTGCTCAGGCAGAAATGG
ACCTTAAGAGACTGAGAGACCCATTACAAGTACATCTGCCTCTCCGACAAATTGGTGAAAAAGATTGATCTGCAAAAAGCCTCTGAATCC
TGGCAGAAGGAACACCTGTTTGCCTTTTTAATTAAAGCATTGCAGGTGGAAGCTGGGAGCCATGTGGGGGGTAGAGCGTTTTTACCTTTA
ATTATAAAACAAAAACAGAAAGGATCTGAGGGAAGAAGGGAATGTTAAAACCTGAGGATCAGGCATTGTGGAATATAAGCTCAAAGGGCT
TAGTGAATATTGTCTTAACCAAGTATCTCAGTTTCTGGATGAAAATGATGCAGTTATATAGTTGAGAGATTCATAAAGAGAAAACAATGC
TGGGGGTGTTCGTTTCTTGCATCTTCTTTGCAGAGTCAGCAAAAGAGTAACACACCAGCACCCCACTCGACTCTATTTGTTTTTAATTTA
ACTGTCCCTATTTTTGACATAGGAGTAAATAAATATACTAGAAAAGCAAATTCTCATGATATGCTAAAATATCATTAGCATTTATTTTAA
ATTGGACCCAGTCTCTGCAGAGTTACCAGGAATCTTTCCTTCCAGCATCCCTTTACTGACCACCTACCTGTACCTCTTGGTTACACTCAT
TTTTTCCATTTGATAATTGGAACCAACTTATAACTGTTTAATAATTGACACTTTAGATTATCTCTTAATACCTTCTTAAATGTCTATATA
TCCCAGTGCTCTGGATCAGTGTCTAAAAATCACTGGCAACACTGCATGAGGTTGTTGGTTTTGTTTTGTTTTATTAATTAGTCTTTCACA
GGAGGAATAATTGCCCTCCTTTATATACTTATCTATTGATAATCCCCTCTCCCTCCAGAACACAAATCAGAGGGAAAGGGGGTGTTCAGC
TGTACTACCAAATCAGGAAGATGTAAGGTTTACAAATTGGCTAAGAATCATGGCTCTGTAGCCATTTCAACCAGAATAATTTTATTGCTA
ATCTGCTTTGTGTGACAGCATTCCAGGCCAGCCAGATGGGACTGCCTTGTCTGGAGGCTTTGTTCATCTCGAAGGACACACACTTCCACA
CTGTTTGTGAGCCCTCCCACCTCCACAACTTCAGTTGTAAATCAAGTGTGTGGATCTCAAAGGGTGCAATTTATCTTTATATAGGAATAC
ATTTCTAGGGCTTCCTTCAAGCCCACTCTCTTCACCCTATTTTTTCTTATCTTAAATTGAGAGAAAGAGAATTAATCTTATACTTTGTCA
AAACATTTTCTACCATATTTCCAGATGACATCTGCGCTTGAAGAGTCAAAGGAATCTGTGTCTAATATCCTGTTTTTAACTGCTGTAGGG
GCAGGATGGAAAGGATGATGGGGGCTGCCACACCACTGATTGGCCTTTTCTTTCACGTGATTCATCCTTCCTCATTGTGGCAAGGAGTTT
CTTTCTCTTTTTCTTCCTCCTTTGGGATCATTGTGTATGAAAAGAAAAACTTTAAATGACAAACCCAGACTCCAGGTGCCTTGCAAAGGT
TGAAGGCCAGCCAGGATTGCTGCTGCTGCTGCTACTCCTGCCAACACCCCTTTCATTGGCATGACGGAATGAAAGGATGCATGTCTCCAC
TTCCTGACCCTCCGCCCACTTCCTTCTCCCTCCACCACCCCCAGTCGTCAGCTCCTTCCCTCATTTATTTTTGTTAAGTTGTGTGAATTA
TTTTTAACCCATTTATCCTGTTTGTGCATAGGGTTTTTAAGAAGAAACAGCACAGTGCAACGAGCAAATCTTTTTGGGGTGTGTGGGAAG
CAAGGGAGGGAGGACATGGAGAAAAGTTCTTTAAACAAATAGCAAACTATTGAACATGTGTAAAATCCTGTATCATTTATGAAATATGTA

>72212_72212_1_RAPGEF1-MCU_RAPGEF1_chr9_134615157_ENST00000372195_MCU_chr10_74594117_ENST00000357157_length(amino acids)=270AA_BP=
MGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFK
LVINDLTYHVRPPKRVEMGFCHVGQNGFELLTSSYLPASASQSAEIIAVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWD
IMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD

--------------------------------------------------------------
>72212_72212_2_RAPGEF1-MCU_RAPGEF1_chr9_134615157_ENST00000372195_MCU_chr10_74594117_ENST00000373053_length(transcript)=3083nt_BP=305nt
CGCTGCGCTGCGGCCGGCTCGCGGGCCGGGGGAGCGGCGGCGGGCGCGCGGGAGGCGGAGCGGCGGCGGCGGGCGCGGCGGGAGCGGCTG
GGCCCGGGCGGGCTGGAGCGCGGTCGCCGAGCGCAGGGCCGCGGCCGCGCGGAGCCCGCCATGCCGGCGCGGGTCTGAGGCGTGGCGAGC
CAGGGCCGAGGCGAGCGGCGGGCGCGCCGCCCCTGTCGCCCCGCGGCGGCCCGGCCCGGGCCCGATGAGCGGCGGCCTCGGCCTCCGGCG
CAGCCCGGAAATGTCCGGCAAGATCGAGAAAGCAGGTACACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTG
TTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAATGGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGT
TCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTTTTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATT
CACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATAGACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACC
ACGTACGACCACCAAAAAGAGACCTCTTAAGTCATGAAAATGCAGCAACGCTGAATGATGTAAAGACATTGGTCCAGCAACTATACACCA
CACTGTGCATTGAGCAGCACCAGTTAAACAAGGAAAGGGAGCTTATTGAAAGACTAGAGGATCTCAAAGAGCAGCTGGCTCCCCTGGAAA
AGGTACGAATTGAGATTAGCAGAAAAGCTGAGAAGAGGACCACTTTGGTGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGGCA
TTTTGGCCCGGCTTACCTGGTGGGAATATTCCTGGGACATCATGGAGCCAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAATGT
ATGCATATTTTGTAATGACACGCCAGGAATATGTTTATCCAGAAGCCAGAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAAAA
AGTCACGTTTTGACCTAGAGAAATACAATCAACTCAAGGATGCAATTGCTCAGGCAGAAATGGACCTTAAGAGACTGAGAGACCCATTAC
AAGTACATCTGCCTCTCCGACAAATTGGTGAAAAAGATTGATCTGCAAAAAGCCTCTGAATCCTGGCAGAAGGAACACCTGTTTGCCTTT
TTAATTAAAGCATTGCAGGTGGAAGCTGGGAGCCATGTGGGGGGTAGAGCGTTTTTACCTTTAATTATAAAACAAAAACAGAAAGGATCT
GAGGGAAGAAGGGAATGTTAAAACCTGAGGATCAGGCATTGTGGAATATAAGCTCAAAGGGCTTAGTGAATATTGTCTTAACCAAGTATC
TCAGTTTCTGGATGAAAATGATGCAGTTATATAGTTGAGAGATTCATAAAGAGAAAACAATGCTGGGGGTGTTCGTTTCTTGCATCTTCT
TTGCAGAGTCAGCAAAAGAGTAACACACCAGCACCCCACTCGACTCTATTTGTTTTTAATTTAACTGTCCCTATTTTTGACATAGGAGTA
AATAAATATACTAGAAAAGCAAATTCTCATGATATGCTAAAATATCATTAGCATTTATTTTAAATTGGACCCAGTCTCTGCAGAGTTACC
AGGAATCTTTCCTTCCAGCATCCCTTTACTGACCACCTACCTGTACCTCTTGGTTACACTCATTTTTTCCATTTGATAATTGGAACCAAC
TTATAACTGTTTAATAATTGACACTTTAGATTATCTCTTAATACCTTCTTAAATGTCTATATATCCCAGTGCTCTGGATCAGTGTCTAAA
AATCACTGGCAACACTGCATGAGGTTGTTGGTTTTGTTTTGTTTTATTAATTAGTCTTTCACAGGAGGAATAATTGCCCTCCTTTATATA
CTTATCTATTGATAATCCCCTCTCCCTCCAGAACACAAATCAGAGGGAAAGGGGGTGTTCAGCTGTACTACCAAATCAGGAAGATGTAAG
GTTTACAAATTGGCTAAGAATCATGGCTCTGTAGCCATTTCAACCAGAATAATTTTATTGCTAATCTGCTTTGTGTGACAGCATTCCAGG
CCAGCCAGATGGGACTGCCTTGTCTGGAGGCTTTGTTCATCTCGAAGGACACACACTTCCACACTGTTTGTGAGCCCTCCCACCTCCACA
ACTTCAGTTGTAAATCAAGTGTGTGGATCTCAAAGGGTGCAATTTATCTTTATATAGGAATACATTTCTAGGGCTTCCTTCAAGCCCACT
CTCTTCACCCTATTTTTTCTTATCTTAAATTGAGAGAAAGAGAATTAATCTTATACTTTGTCAAAACATTTTCTACCATATTTCCAGATG
ACATCTGCGCTTGAAGAGTCAAAGGAATCTGTGTCTAATATCCTGTTTTTAACTGCTGTAGGGGCAGGATGGAAAGGATGATGGGGGCTG
CCACACCACTGATTGGCCTTTTCTTTCACGTGATTCATCCTTCCTCATTGTGGCAAGGAGTTTCTTTCTCTTTTTCTTCCTCCTTTGGGA
TCATTGTGTATGAAAAGAAAAACTTTAAATGACAAACCCAGACTCCAGGTGCCTTGCAAAGGTTGAAGGCCAGCCAGGATTGCTGCTGCT
GCTGCTACTCCTGCCAACACCCCTTTCATTGGCATGACGGAATGAAAGGATGCATGTCTCCACTTCCTGACCCTCCGCCCACTTCCTTCT
CCCTCCACCACCCCCAGTCGTCAGCTCCTTCCCTCATTTATTTTTGTTAAGTTGTGTGAATTATTTTTAACCCATTTATCCTGTTTGTGC
ATAGGGTTTTTAAGAAGAAACAGCACAGTGCAACGAGCAAATCTTTTTGGGGTGTGTGGGAAGCAAGGGAGGGAGGACATGGAGAAAAGT
TCTTTAAACAAATAGCAAACTATTGAACATGTGTAAAATCCTGTATCATTTATGAAATATGTATAAAAAGCAATGTACCTTCTGGAACAA

>72212_72212_2_RAPGEF1-MCU_RAPGEF1_chr9_134615157_ENST00000372195_MCU_chr10_74594117_ENST00000373053_length(amino acids)=291AA_BP=
MGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFK
LVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGL
AYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMD

--------------------------------------------------------------
>72212_72212_3_RAPGEF1-MCU_RAPGEF1_chr9_134615157_ENST00000372195_MCU_chr10_74594117_ENST00000536019_length(transcript)=3081nt_BP=305nt
CGCTGCGCTGCGGCCGGCTCGCGGGCCGGGGGAGCGGCGGCGGGCGCGCGGGAGGCGGAGCGGCGGCGGCGGGCGCGGCGGGAGCGGCTG
GGCCCGGGCGGGCTGGAGCGCGGTCGCCGAGCGCAGGGCCGCGGCCGCGCGGAGCCCGCCATGCCGGCGCGGGTCTGAGGCGTGGCGAGC
CAGGGCCGAGGCGAGCGGCGGGCGCGCCGCCCCTGTCGCCCCGCGGCGGCCCGGCCCGGGCCCGATGAGCGGCGGCCTCGGCCTCCGGCG
CAGCCCGGAAATGTCCGGCAAGATCGAGAAAGCAGGTACACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTG
TTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAATGGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGT
TCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTTTTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATT
CACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATAGACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACC
ACGTACGACCACCAAAAAGAGACCTCTTAAGTCATGAAAATGCAGCAACGCTGAATGATGTAAAGACATTGGTCCAGCAACTATACACCA
CACTGTGCATTGAGCAGCACCAGTTAAACAAGGAAAGGGAGCTTATTGAAAGACTAGAGGATCTCAAAGAGCAGCTGGCTCCCCTGGAAA
AGGTACGAATTGAGATTAGCAGAAAAGCTGAGAAGAGGACCACTTTGGTGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGGCA
TTTTGGCCCGGCTTACCTGGTGGGAATATTCCTGGGACATCATGGAGCCAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAATGT
ATGCATATTTTGTAATGACACGCCAGGAATATGTTTATCCAGAAGCCAGAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAAAA
AGTCACGTTTTGACCTAGAGAAATACAATCAACTCAAGGATGCAATTGCTCAGGCAGAAATGGACCTTAAGAGACTGAGAGACCCATTAC
AAGTACATCTGCCTCTCCGACAAATTGGTGAAAAAGATTGATCTGCAAAAAGCCTCTGAATCCTGGCAGAAGGAACACCTGTTTGCCTTT
TTAATTAAAGCATTGCAGGTGGAAGCTGGGAGCCATGTGGGGGGTAGAGCGTTTTTACCTTTAATTATAAAACAAAAACAGAAAGGATCT
GAGGGAAGAAGGGAATGTTAAAACCTGAGGATCAGGCATTGTGGAATATAAGCTCAAAGGGCTTAGTGAATATTGTCTTAACCAAGTATC
TCAGTTTCTGGATGAAAATGATGCAGTTATATAGTTGAGAGATTCATAAAGAGAAAACAATGCTGGGGGTGTTCGTTTCTTGCATCTTCT
TTGCAGAGTCAGCAAAAGAGTAACACACCAGCACCCCACTCGACTCTATTTGTTTTTAATTTAACTGTCCCTATTTTTGACATAGGAGTA
AATAAATATACTAGAAAAGCAAATTCTCATGATATGCTAAAATATCATTAGCATTTATTTTAAATTGGACCCAGTCTCTGCAGAGTTACC
AGGAATCTTTCCTTCCAGCATCCCTTTACTGACCACCTACCTGTACCTCTTGGTTACACTCATTTTTTCCATTTGATAATTGGAACCAAC
TTATAACTGTTTAATAATTGACACTTTAGATTATCTCTTAATACCTTCTTAAATGTCTATATATCCCAGTGCTCTGGATCAGTGTCTAAA
AATCACTGGCAACACTGCATGAGGTTGTTGGTTTTGTTTTGTTTTATTAATTAGTCTTTCACAGGAGGAATAATTGCCCTCCTTTATATA
CTTATCTATTGATAATCCCCTCTCCCTCCAGAACACAAATCAGAGGGAAAGGGGGTGTTCAGCTGTACTACCAAATCAGGAAGATGTAAG
GTTTACAAATTGGCTAAGAATCATGGCTCTGTAGCCATTTCAACCAGAATAATTTTATTGCTAATCTGCTTTGTGTGACAGCATTCCAGG
CCAGCCAGATGGGACTGCCTTGTCTGGAGGCTTTGTTCATCTCGAAGGACACACACTTCCACACTGTTTGTGAGCCCTCCCACCTCCACA
ACTTCAGTTGTAAATCAAGTGTGTGGATCTCAAAGGGTGCAATTTATCTTTATATAGGAATACATTTCTAGGGCTTCCTTCAAGCCCACT
CTCTTCACCCTATTTTTTCTTATCTTAAATTGAGAGAAAGAGAATTAATCTTATACTTTGTCAAAACATTTTCTACCATATTTCCAGATG
ACATCTGCGCTTGAAGAGTCAAAGGAATCTGTGTCTAATATCCTGTTTTTAACTGCTGTAGGGGCAGGATGGAAAGGATGATGGGGGCTG
CCACACCACTGATTGGCCTTTTCTTTCACGTGATTCATCCTTCCTCATTGTGGCAAGGAGTTTCTTTCTCTTTTTCTTCCTCCTTTGGGA
TCATTGTGTATGAAAAGAAAAACTTTAAATGACAAACCCAGACTCCAGGTGCCTTGCAAAGGTTGAAGGCCAGCCAGGATTGCTGCTGCT
GCTGCTACTCCTGCCAACACCCCTTTCATTGGCATGACGGAATGAAAGGATGCATGTCTCCACTTCCTGACCCTCCGCCCACTTCCTTCT
CCCTCCACCACCCCCAGTCGTCAGCTCCTTCCCTCATTTATTTTTGTTAAGTTGTGTGAATTATTTTTAACCCATTTATCCTGTTTGTGC
ATAGGGTTTTTAAGAAGAAACAGCACAGTGCAACGAGCAAATCTTTTTGGGGTGTGTGGGAAGCAAGGGAGGGAGGACATGGAGAAAAGT
TCTTTAAACAAATAGCAAACTATTGAACATGTGTAAAATCCTGTATCATTTATGAAATATGTATAAAAAGCAATGTACCTTCTGGAACAA

>72212_72212_3_RAPGEF1-MCU_RAPGEF1_chr9_134615157_ENST00000372195_MCU_chr10_74594117_ENST00000536019_length(amino acids)=291AA_BP=
MGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFK
LVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGL
AYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RAPGEF1-MCU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for RAPGEF1-MCU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for RAPGEF1-MCU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource