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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RAPGEF1-SEC16A (FusionGDB2 ID:72217)

Fusion Gene Summary for RAPGEF1-SEC16A

Fusion gene summary

Fusion gene information	Fusion gene name: RAPGEF1-SEC16A
	Fusion gene ID: 72217
		Hgene	Tgene
	Gene symbol	RAPGEF1	SEC16A
	Gene ID	2889	9919
	Gene name	Rap guanine nucleotide exchange factor 1	SEC16 homolog A, endoplasmic reticulum export factor
	Synonyms	C3G\|GRF2	KIAA0310\|SEC16L\|p250
	Cytomap	9q34.13	9q34.3
	Type of gene	protein-coding	protein-coding
	Description	rap guanine nucleotide exchange factor 1CRK SH3-binding GNRPRap guanine nucleotide exchange factor (GEF) 1guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)	protein transport protein Sec16Aprotein SEC16 homolog A
	Modification date	20200327	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000372195, ENST00000372189, ENST00000372190, ENST00000481260,	ENST00000290037, ENST00000313084, ENST00000371706, ENST00000398335, ENST00000431893, ENST00000467838, ENST00000313050,
Fusion gene scores	* DoF score	20 X 16 X 11=3520	10 X 8 X 7=560
	# samples	23	11
	** MAII score	log2(23/3520*10)=-3.93586966258028 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/560*10)=-2.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RAPGEF1 [Title/Abstract] AND SEC16A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RAPGEF1(134615157)-SEC16A(139372136), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RAPGEF1	GO:0038180	nerve growth factor signaling pathway	17724123
Hgene	RAPGEF1	GO:0043547	positive regulation of GTPase activity	10548487
Hgene	RAPGEF1	GO:0071320	cellular response to cAMP	21840392
Hgene	RAPGEF1	GO:1990090	cellular response to nerve growth factor stimulus	17724123
Tgene	SEC16A	GO:0007029	endoplasmic reticulum organization	21768384
Tgene	SEC16A	GO:0034976	response to endoplasmic reticulum stress	28067262

Fusion gene breakpoints across RAPGEF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SEC16A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-HT-7483-01A	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-

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Fusion Gene ORF analysis for RAPGEF1-SEC16A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000372195	ENST00000290037	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
5CDS-intron	ENST00000372195	ENST00000313084	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
5CDS-intron	ENST00000372195	ENST00000371706	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
5CDS-intron	ENST00000372195	ENST00000398335	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
5CDS-intron	ENST00000372195	ENST00000431893	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
5CDS-intron	ENST00000372195	ENST00000467838	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
In-frame	ENST00000372195	ENST00000313050	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-3CDS	ENST00000372189	ENST00000313050	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-3CDS	ENST00000372190	ENST00000313050	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-3CDS	ENST00000481260	ENST00000313050	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000372189	ENST00000290037	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000372189	ENST00000313084	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000372189	ENST00000371706	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000372189	ENST00000398335	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000372189	ENST00000431893	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000372189	ENST00000467838	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000372190	ENST00000290037	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000372190	ENST00000313084	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000372190	ENST00000371706	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000372190	ENST00000398335	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000372190	ENST00000431893	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000372190	ENST00000467838	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000481260	ENST00000290037	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000481260	ENST00000313084	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000481260	ENST00000371706	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000481260	ENST00000398335	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000481260	ENST00000431893	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-
intron-intron	ENST00000481260	ENST00000467838	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000372195

RAPGEF1

chr9

134615157

ENST00000313050

SEC16A

chr9

139372136

9111

305

7452

2481

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000372195	ENST00000313050	RAPGEF1	chr9	134615157	-	SEC16A	chr9	139372136	-	0.00177575	0.9982242

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Fusion Genomic Features for RAPGEF1-SEC16A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAPGEF1-SEC16A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:134615157/chr9:139372136)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000290037

1113_1181

2160.0

Compositional bias

Note=Pro-rich

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000290037

1159_1162

2160.0

Compositional bias

Note=Poly-Tyr

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000290037

1591_1594

2160.0

Compositional bias

Note=Poly-Glu

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000290037

1931_2285

2160.0

Compositional bias

Note=Pro-rich

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000371706

1113_1181

2135.0

Compositional bias

Note=Pro-rich

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000371706

1159_1162

2135.0

Compositional bias

Note=Poly-Tyr

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000371706

1591_1594

2135.0

Compositional bias

Note=Poly-Glu

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000371706

1931_2285

2135.0

Compositional bias

Note=Pro-rich

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000431893

1113_1181

2155.0

Compositional bias

Note=Pro-rich

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000431893

1159_1162

2155.0

Compositional bias

Note=Poly-Tyr

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000431893

1591_1594

2155.0

Compositional bias

Note=Poly-Glu

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000431893

1931_2285

2155.0

Compositional bias

Note=Pro-rich

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000290037

1019_1890

2160.0

Region

Required for localization to endoplasmic reticulum exit sites

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000290037

1102_1405

2160.0

Region

Required for endoplasmic reticulum localization

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000371706

1019_1890

2135.0

Region

Required for localization to endoplasmic reticulum exit sites

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000371706

1102_1405

2135.0

Region

Required for endoplasmic reticulum localization

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000431893

1019_1890

2155.0

Region

Required for localization to endoplasmic reticulum exit sites

Tgene

SEC16A

chr9:134615157

chr9:139372136

ENST00000431893

1102_1405

2155.0

Region

Required for endoplasmic reticulum localization

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RAPGEF1

chr9:134615157

chr9:139372136

ENST00000372189

963_966

1078.0

Compositional bias

Note=Poly-Ser

Hgene

RAPGEF1

chr9:134615157

chr9:139372136

ENST00000372190

963_966

1096.0

Compositional bias

Note=Poly-Ser

Hgene

RAPGEF1

chr9:134615157

chr9:139372136

ENST00000372189

688_810

1078.0

Domain

N-terminal Ras-GEF

Hgene

RAPGEF1

chr9:134615157

chr9:139372136

ENST00000372189

840_1064

1078.0

Domain

Ras-GEF

Hgene

RAPGEF1

chr9:134615157

chr9:139372136

ENST00000372190

688_810

1096.0

Domain

N-terminal Ras-GEF

Hgene

RAPGEF1

chr9:134615157

chr9:139372136

ENST00000372190

840_1064

1096.0

Domain

Ras-GEF

Hgene

RAPGEF1

chr9:134615157

chr9:139372136

ENST00000372189

281_292

1078.0

Motif

Note=SH3-binding

Hgene

RAPGEF1

chr9:134615157

chr9:139372136

ENST00000372189

451_462

1078.0

Motif

Note=SH3-binding

Hgene

RAPGEF1

chr9:134615157

chr9:139372136

ENST00000372189

538_549

1078.0

Motif

Note=SH3-binding

Hgene

RAPGEF1

chr9:134615157

chr9:139372136

ENST00000372189

606_617

1078.0

Motif

Note=SH3-binding

Hgene

RAPGEF1

chr9:134615157

chr9:139372136

ENST00000372190

281_292

1096.0

Motif

Note=SH3-binding

Hgene

RAPGEF1

chr9:134615157

chr9:139372136

ENST00000372190

451_462

1096.0

Motif

Note=SH3-binding

Hgene

RAPGEF1

chr9:134615157

chr9:139372136

ENST00000372190

538_549

1096.0

Motif

Note=SH3-binding

Hgene

RAPGEF1

chr9:134615157

chr9:139372136

ENST00000372190

606_617

1096.0

Motif

Note=SH3-binding

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Fusion Gene Sequence for RAPGEF1-SEC16A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>72217_72217_1_RAPGEF1-SEC16A_RAPGEF1_chr9_134615157_ENST00000372195_SEC16A_chr9_139372136_ENST00000313050_length(transcript)=9111nt_BP=305nt
CGCTGCGCTGCGGCCGGCTCGCGGGCCGGGGGAGCGGCGGCGGGCGCGCGGGAGGCGGAGCGGCGGCGGCGGGCGCGGCGGGAGCGGCTG
GGCCCGGGCGGGCTGGAGCGCGGTCGCCGAGCGCAGGGCCGCGGCCGCGCGGAGCCCGCCATGCCGGCGCGGGTCTGAGGCGTGGCGAGC
CAGGGCCGAGGCGAGCGGCGGGCGCGCCGCCCCTGTCGCCCCGCGGCGGCCCGGCCCGGGCCCGATGAGCGGCGGCCTCGGCCTCCGGCG
CAGCCCGGAAATGTCCGGCAAGATCGAGAAAGCAGTCCAGCTCCAATTAAGGAACAGCTATATCCTGCTTCCTTCTGTAAGCAGCATCGA
CTTGTGCAAGGGTTCAGTCATGCAGCCACCGCCCCAGACGGTCCCGTCTGGCATGGCTGGGCCACCTCCAGCCGGGAATCCTCGGAGCGT
GTTCTGGGCTAGCAGCCCTTACAGGAGACGGGCTAATAATAATGCAGCAGTGGCTCCGACAACTTGCCCGTTGCAGCCGGTCACGGATCC
ATTTGCTTTTAGTAGACAGGCGCTCCAAAGTACACCACTGGGCAGTTCGTCCAAAAGCAGTCCACCTGTCTTGCAAGGCCCAGCCCCCGC
AGGGTTTTCTCAGCACCCCGGTTTGCTTGTTCCTCACACACATGCCAGAGATAGCTCTCAGGGACCCTGTGAGCCCCTGCCTGGACCTCT
GACACAGCCCAGAGCACATGCCAGTCCGTTTTCTGGTGCATTGACACCTTCAGCACCTCCTGGGCCTGAGATGAACAGGAGTGCAGAGGT
CGGTCCCAGTTCAGAGCCTGAAGTTCAGACTCTGCCATATCTTCCTCACTACATTCCAGGAGTGGATCCTGAAACGTCTCATGGGGGCCA
CCCTCATGGGAACATGCCTGGGCTCGACCGACCCCTGAGCAGGCAAAACCCACATGACGGTGTGGTCACCCCAGCAGCATCCCCTTCCCT
CCCTCAGCCTGGTCTGCAGATGCCAGGACAGTGGGGGCCAGTGCAGGGAGGCCCACAGCCCTCGGGGCAACATCGTTCACCCTGCCCTGA
AGGACCTGTTCCCAGCGGGGTGCCCTGTGCCACCAGCGTTCCTCATTTCCCCACCCCGTCCATCCTACATCAGGGCCCTGGTCATGAGCA
ACACAGCCCTCTGGTGGCTCCCCCAGCAGCCTTGCCCAGTGACGGAAGAGACGAGGTGAGCCACTTGCAAAGTGGAAGCCACCTGGCCAA
TAACTCTGATCCTGAAAGTACATTCAGGCAAAATCCCAGAATTGTGAATCACTGGGCAAGCCCAGAGCTCAGGCAGAATCCAGGAGTGAA
GAATGAGCACCGGCCCGCCTCTGCTCTTGTGAACCCCCTCGCCCGGGGAGATAGCCCAGAAAACCGTACGCACCACCCACTGGGGGCTGG
GGCCGGGTCTGGCTGTGCCCCGCTAGAAGCAGACTCAGGAGCTTCAGGAGCTCTGGCGATGTTTTTCCAAGGGGGAGAGACAGAAAATGA
GGAGAATCTCTCATCTGAAAAAGCAGGCTTATCTGGTCAAGCGGACTTTGACGATTTCTGCTCCAGCCCTGGGCTAGGCCGTCCGCCCGC
ACCTACACACGTGGGGGCAGGCAGCCTCTGCCAGGCCCTTCTCCCAGGCCCCAGCAATGAGGCTGCTGGTGATGTGTGGGGTGACACAGC
GAGCACAGGGGTGCCGGATGCCAGCGGCTCGCAGTATGAGAATGTTGAGAACTTAGAATTTGTTCAGAATCAAGAAGTTCTGCCAAGTGA
GCCCCTCAATTTGGACCCTTCCTCCCCGAGTGACCAGTTCAGATATGGGCCCCTTCCTGGGCCAGCTGTGCCCAGGCATGGTGCTGTGTG
CCACACCGGAGCCCCTGATGCCACACTGCATACAGTGCACCCTGACAGCGTGTCATCCAGCTATAGCAGCAGAAGCCACGGAAGGCTCTC
AGGCTCAGCCAGGCCCCAGGAGCTGGTTGGCACATTCATTCAGCAAGAAGTTGGAAAACCCGAGGATGAAGCTTCAGGTAGTTTTTTTAA
GCAAATCGATTCTTCTCCCGTAGGAGGTGAAACAGACGAGACCACTGTGAGCCAGAATTACCGTGGCAGCGTGTCCCAGCCCTCAACCCC
GAGCCCCCCGAAACCTACAGGAATATTTCAGACAAGTGCAAATAGTTCTTTCGAACCGGTAAAATCTCACTTAGTTGGGGTAAAACCATT
TGAGGCAGATCGCGCCAACGTGGTTGGTGAAGTAAGGGAGACCTGTGTCCGCCAGAAGCAGTGCAGACCAGCTGCCGCCCTGCCCGATGC
TTCCCCTGGCAACCTGGAGCAGCCACCAGACAACATGGAGACCCTCTGTGCACCCCAGGTCTGTCCCCTGCCTCTTAACTCCACCACGGA
AGCTGTGCACATGCTTCCGCACGCAGGGGCACCGCCCTTGGATACTGTGTATCCAGCACCCGAGAAGAGGCCTTCAGCCAGGACCCAGGG
GCCCGTGAAGTGTGAGAGCCCAGCAACGACTCTGTGGGCGCAAAGTGAGCTGCCAGATTTTGGAGGCAACGTCCTTCTGGCCCCTGCAGC
CCCGGCGCTTTATGTGTGTGCAAAACCTCAGCCACCTGTTGTTCAGCCTCCAGAAGAGGCGATGTCCGGGCAGCAGTCACGGAACCCAAG
CTCGGCGGCCCCGGTGCAGAGCCGAGGTGGCATTGGTGCTTCTGAGAACCTTGAGAATCCTCCCAAAATGGGAGAGGAGGAGGCCCTTCA
GTCCCAGGCGAGTTCTGGTTATGCAAGTTTATTATCCTCACCGCCCACTGAGTCTCTGCAGAATCCTCCAGTCTTGATTGCTCAGCCTGA
TCACAGCTATAATCTGGCTCAGCCCATTAACTTTTCTGTGTCCTTATCGAACTCTCATGAGAAGAATCAGTCCTGGAGAGAGGCTTTGGT
GGGGGATAGACCTGCAGTCAGCAGTTGGGCTCTCGGTGGTGATTCTGGGGAGAACACTTCTTTGTCTGGGATTCCAACCAGCTCTGTCCT
TAGCTTGTCTCTGCCTAGCAGTGTTGCCCAAAGTAATTTTCCACAAGGTTCTGGTGCTTCCGAAATGGTTTCTAATCAGCCTGCTAATTT
GCTGGTTCAACCACCATCCCAGCCAGTTCCAGAGAACTTGGTTCCAGAAAGTCAAAAGGATCGTAAGGCAGGAAGTGCTCTTCCCGGATT
TGCTAATAGCCCTGCTGGAAGCACAAGTGTGGTGTTAGTTCCACCTGCACACGGCACCCTGGTGCCTGATGGTAATAAGGCAAACCATTC
CAGTCATCAGGAAGACACTTACGGAGCCCTAGACTTTACCTTAAGCAGGACTTTGGAAAATCCTGTAAACGTGTACAACCCGTCCCATTC
TGACAGCCTCGCTTCTCAGCAAAGTGTTGCCAGTCATCCCAGACAATCTGGGCCTGGGGCGCCTAACCTTGACCGTTTTTATCAGCAGGT
CACGAAAGATGCCCAGGGCCAGCCTGGCCTCGAAAGAGCCCAGCAGGAGCTGGTGCCACCCCAGCAACAGGCTTCTCCCCCACAACTACC
CAAAGCCATGTTTTCGGAGCTGTCAAATCCAGAAAGTCTGCCCGCACAGGGACAGGCCCAGAACTCAGCACAGTCACCAGCAAGTCTGGT
TCTGGTCGACGCGGGTCAGCAGCTGCCCCCTCGGCCTCCTCAGTCCTCTAGCGTGTCTCTGGTGTCCAGTGGCTCCGGCCAGGCAGCTGT
GCCGTCAGAGCAGCCGTGGCCACAGCCAGTGCCTGCACTTGCCCCCGGCCCACCGCCTCAGGACCTGGCCGCCTACTACTACTACCGGCC
TTTGTACGATGCCTACCAGCCTCAGTACTCTTTGCCGTACCCACCGGAGCCTGGCGCAGCCTCCCTCTATTACCAGGATGTCTACAGCCT
CTATGAGCCTCGATACAGGCCCTATGATGGTGCTGCGTCTGCTTACGCCCAGAACTACCGCTATCCCGAGCCCGAGCGGCCCAGCTCCCG
AGCCAGCCACTCCTCGGAACGGCCACCTCCCAGGCAAGGATATCCTGAAGGATACTATAGTTCCAAAAGTGGATGGAGCAGTCAGAGCGA
TTACTATGCAAGCTATTACTCCAGCCAGTACGATTATGGAGATCCAGGTCACTGGGATCGTTACCACTACAGTGCTAGAGTCAGGGACCC
CCGCACCTATGACCGGAGGTATTGGTGTGATGCAGAGTATGACGCATACAGGAGAGAGCACTCTGCCTTCGGGGACAGGCCCGAGAAACG
TGACAACAACTGGAGGTACGATCCTCGCTTCACGGGGAGTTTTGACGATGACCCCGATCCGCACAGAGACCCTTATGGGGAAGAGGTGGA
CCGGCGCAGCGTCCACAGCGAGCACTCGGCACGGAGCCTGCACAGCGCACACAGCCTGGCCAGCCGCCGCAGCAGCCTCAGCTCCCACTC
GCACCAGAGTCAGATTTACAGAAGCCACAATGTGGCTGCCGGTTCCTACGAGGCCCCGCTTCCTCCAGGCTCCTTTCACGGCGATTTTGC
CTACGGCACCTACCGCAGCAATTTCAGCAGTGGCCCCGGCTTCCCAGAGTATGGCTACCCTGCCGACACCGTCTGGCCTGCCATGGAGCA
AGTTTCATCAAGACCAACTTCTCCTGAAAAATTTTCAGTGCCTCATGTCTGTGCCAGGTTTGGCCCTGGCGGTCAGCTTATCAAAGTGAT
TCCCAATCTGCCTTCAGAAGGACAGCCGGCCTTGGTGGAGGTCCACAGCATGGAGGCCTTGCTGCAGCACACGTCTGAGCAGGAGGAGAT
GCGGGCGTTCCCGGGACCCCTGGCCAAAGACGACACCCATAAGGTGGATGTCATTAATTTTGCACAGAACAAAGCTATGAAATGTTTGCA
GAATGAAAACTTAATTGACAAAGAGTCTGCAAGTCTTCTTTGGAATTTTATTGTTCTCTTATGCAGACAAAATGGGACCGTGGTAGGGAC
CGACATTGCGGAGCTTCTGTTACGAGACCACAGAACAGTGTGGCTTCCTGGGAAGTCGCCCAATGAAGCAAACCTGATTGATTTCACGAA
TGAGGCAGTGGAGCAGGTGGAAGAGGAGGAGTCTGGTGAGGCCCAGCTCTCTTTCCTCACTGGTGGTCCGGCGGCTGCCGCCAGCTCGCT
CGAGAGAGAGACCGAGAGGTTCAGGGAGCTGTTGCTGTATGGCCGTAAGAAGGATGCTTTGGAGTCTGCAATGAAGAATGGCCTGTGGGG
TCACGCTCTGCTACTTGCAAGTAAGATGGACAGCCGGACACACGCCCGAGTCATGACCAGGTTTGCTAACAGCCTCCCAATCAACGACCC
TCTGCAGACAGTCTACCAGCTCATGTCCGGACGGATGCCTGCCGCGTCCACGTGCTGTGGAGACGAGAAATGGGGAGATTGGAGGCCGCA
CCTCGCCATGGTCTTGTCCAACTTGAACAACAACATGGACGTCGAGTCCAGGACGATGGCTACCATGGGCGACACTCTGGCTTCAAGGGG
CCTCTTGGATGCGGCCCACTTCTGCTACCTCATGGCCCAGGCGGGATTTGGTGTTTACACGAAGAAAACTACAAAGCTTGTCTTAATCGG
ATCCAATCACAGTTTGCCATTCTTAAAGTTCGCAACCAACGAAGCAATCCAGAGGACGGAAGCCTATGAGTACGCCCAGTCCCTGGGTGC
CGAGACCTGCCCCCTGCCTAGTTTCCAGGTGTTTAAGTTCATCTACTCCTGCCGCCTGGCGGAAATGGGGCTGGCCACGCAAGCCTTCCA
CTACTGTGAGGCCATCGCGAAGAGCATCCTGACGCAGCCGCACCTGTATTCCCCGGTGTTGATCAGCCAGCTTGTGCAGATGGCTTCCCA
GTTACGACTCTTCGATCCCCAGCTGAAAGAGAAGCCAGAAGAGGAGTCCTTGGCCGCACCCACGTGGCTGGTTCACCTGCAGCAGGTGGA
GCGGCAGATTAAGGAGGGGGCTGGAGTATGGCATCAGGATGGAGCCCTCCCGCAGCAGTGTCCTGGCACTCCGAGTTCCGAGATGGAGCA
GTTGGACAGGCCAGGACTCAGTCAGCCAGGAGCCCTGGGGATCGCCAACCCTCTGCTGGCGGTGCCTGCACCGAGCCCTGAGCACTCGAG
CCCGAGCGTGCGGCTGCTGCCCTCAGCTCCGCAGACGCTCCCTGACGGCCCATTGGCCAGTCCTGCCAGAGTGCCGATGTTCCCAGTGCC
ACTGCCCCCGGGGCCCCTGGAGCCGGGTCCTGGCTGTGTGACCCCAGGGCCTGCACTTGGCTTCCTGGAGCCCTCCGGGCCTGGCCTCCC
ACCTGGTGTGCCACCTCTGCAGGAAAGGAGACACTTGCTCCAGGAAGCCAGGAGCCCAGACCCAGGGATAGTGCCGCAGGAGGCGCCTGT
TGGAAACTCACTTTCCGAGCTAAGCGAAGAAAATTTTGATGGAAAATTTGCTAATCTGACCCCCTCGAGGACGGTGCCAGACTCGGAGGC
CCCCCCAGGGTGGGATCGTGCCGACTCGGGTCCCACGCAGCCACCTCTGTCTCTCTCACCCGCTCCCGAAACAAAGAGACCCGGACAGGC
AGCCAAGAAAGAAACGAAGGAACCTAAGAAGGGTGAATCCTGGTTCTTTCGTTGGCTACCTGGAAAGAAAAAGACAGAAGCTTATTTGCC
AGATGACAAGAACAAATCGATTGTTTGGGATGAAAAGAAAAACCAGTGGGTGAATTTAAATGAGCCAGAAGAGGAGAAGAAAGCCCCGCC
CCCACCTCCAACCTCGATGCCCAAGACTGTGCAAGCTGCCCCGCCTGCCCTCCCAGGGCCTCCTGGAGCCCCCGTGAACATGTACTCTAG
AAGAGCAGCAGGAACCAGAGCTCGCTACGTTGACGTCCTGAACCCAAGCGGGACCCAGCGGAGCGAGCCGGCTCTCGCTCCTGCGGACTT
TGTCGCTCCACTCGCGCCACTCCCAATTCCTTCTAACTTGTTCGTGCCAACCCCAGATGCAGAAGAACCACAGCTTCCAGACGGGACTGG
CAGGGAAGGGCCTGCAGCAGCTAGGGGCCTGGCCAATCCAGAGCCTGCCCCAGAGCCCAAGGTTTTAAGCTCTGCAGCGTCACTCCCTGG
CTCTGAACTCCCCTCCTCCAGGCCTGAGGGTTCCCAGGGAGGAGAGCTTTCGCGCTGTAGTTCAATGAGTTCATTATCACGTGAAGTGAG
CCAGCATTTTAATCAGGCTCCTGGCGACCTCCCTGCTGCAGGGGGCCCTCCCAGCGGGGCCATGCCCTTCTACAACCCTGCTCAGCTGGC
ACAGGCCTGCGCCACCTCCGGGAGCTCAAGGCTAGGGAGGATTGGCCAGAGGAAGCACCTGGTGCTGAACTAGGCTTGCCCTGCTGTGAA
CTTGCACTTGGAGCCCTGACGCTGCTGTTCTCCCCGAAGAACCCGACCGACCTCCGCGATCTCCGTCCCGCCCCCAGGGAGACACAGCAG
TGACTCAGAGCTGGTCGCACACTGTGCCTCCCTCCTCACCGCCCATCGTAATGAATTATTTTGAAAATTAATTCCACCATCCTTTCAGAT
TCTGGATGGAAAGACTGAATCTTTGACTCAGAATTGTTTGCCGAAAAGAATGATGTGACTTTCTTAGTCATTTAGGATGATTTAAGGATA
TAGTATTCCTGGTCATTTAAGAATGTTCATTCATTGAAGCCGGAGCTGTCTCTGCCACAGGAGAGCCACATGGTCGGTAGTAACCAGGGC
CTCTCCAAGCCCAGCTGTGAGTCACTGCCCAGTGAGTCCCGCGCTTCCTTTAAGGTGCTGGGAGCAAAGAGAGGGTGACTGAGGCAGACC
CCAACCCCTGCTCTGCACCATCTGGGCCCTCGCCGTGTTTGAACCTGGCTGAATGAGTGGAGGGCGCTGTGTTCTCAATCAGCGCCTCCG
AGGAGCCGTGGGGTTCCTTCGGCATTAGTTCACGGTTTTTGAGAGAGGCCTTAGTTACTGCAGTGAATTTCTTTCCTGTTGCAAAGACGC
TTCCAGCCTCACTTTACTTTCTGTGGCCTGATGAGGACCATGGGTGATTTTGTGTACCCAAAGCGCTGGGGACTGCCCACCGTGTGGCCC
AGTCACTGGGAAGGAGCCCCAGAGAGCCGGCTGTCTGACATGATGGCTCAGGGTGGTCATCCAGGTTGAAAACTGACCGTGTGATGTTTG
ATTTGGGCTTCATTTCGTGTGTAGGAGCACGGTTAGACTCACTGTTAAGGAAGCTGGATGCACTTCTCTAAAAGGCTGCACTTTCCGTGA
GCACTTTTCGTGGTACAATCCACATGACCCACTTTCTCCCCTGGGGGACGTTGGTTCAGAGGTTGGTAGCACTTGGGGAGAGTATCTTAA
CACAGTTTCTTGACAGCAGCTCTGGAACTTAGTATTTCTGCCCCGAGTTTTGCCACACTGAGACTTTGAGTAGCTCCTGGTGGACTCAAC
CCTGTTCAACTCAGAGACGGGCCTCCTCTCACTGATGCAAAGCTTTAAGGCTTCTCTGACTGTTCTGAAACTCTTCGTATTCTTGTCAAG
TCTAAAGAGACTGAAGAAAAGATTTAAATACTAATAAAAATCAGTAGATAATTTCTGTAGGTTCTGCTGGAGGAATACAAACTGTTTGGT
GTTTTAAATTTAAGTGTAGAAATTGTAGAATGTGGAATTAGCACAGATCCTTCCTGGCTTTCTGTTTCACTTGATCATTTAGCCCAGACC
ACCCAGGATGTTTTCCAAAATGTTCCACAGGCGTGTCCCGCTGGATCCATTTGTCCTTGTCACTTGGAGAAAGGCCAGTCCCTGTGACGG
GGCAGCCCTCTCTGTCCCTCGGTCAGCTCGTGTGAATCCTGGGACCTCTTCCGGTCGGCTCTGCCCGCTGTTCTGGGGTCGACTGCCACG
ACTTTTGATTCAAGAAGCTTCCTCCAGGCGGGAGCGGCTATTTTTCCTAAATGAGAATTGTTACATTGCAAATTGTTGAATAAAATATTT

>72217_72217_1_RAPGEF1-SEC16A_RAPGEF1_chr9_134615157_ENST00000372195_SEC16A_chr9_139372136_ENST00000313050_length(amino acids)=2481AA_BP=2
MRPARGPGERRRARGRRSGGGGRGGSGWARAGWSAVAERRAAAARSPPCRRGSEAWRARAEASGGRAAPVAPRRPGPGPMSGGLGLRRSP
EMSGKIEKAVQLQLRNSYILLPSVSSIDLCKGSVMQPPPQTVPSGMAGPPPAGNPRSVFWASSPYRRRANNNAAVAPTTCPLQPVTDPFA
FSRQALQSTPLGSSSKSSPPVLQGPAPAGFSQHPGLLVPHTHARDSSQGPCEPLPGPLTQPRAHASPFSGALTPSAPPGPEMNRSAEVGP
SSEPEVQTLPYLPHYIPGVDPETSHGGHPHGNMPGLDRPLSRQNPHDGVVTPAASPSLPQPGLQMPGQWGPVQGGPQPSGQHRSPCPEGP
VPSGVPCATSVPHFPTPSILHQGPGHEQHSPLVAPPAALPSDGRDEVSHLQSGSHLANNSDPESTFRQNPRIVNHWASPELRQNPGVKNE
HRPASALVNPLARGDSPENRTHHPLGAGAGSGCAPLEADSGASGALAMFFQGGETENEENLSSEKAGLSGQADFDDFCSSPGLGRPPAPT
HVGAGSLCQALLPGPSNEAAGDVWGDTASTGVPDASGSQYENVENLEFVQNQEVLPSEPLNLDPSSPSDQFRYGPLPGPAVPRHGAVCHT
GAPDATLHTVHPDSVSSSYSSRSHGRLSGSARPQELVGTFIQQEVGKPEDEASGSFFKQIDSSPVGGETDETTVSQNYRGSVSQPSTPSP
PKPTGIFQTSANSSFEPVKSHLVGVKPFEADRANVVGEVRETCVRQKQCRPAAALPDASPGNLEQPPDNMETLCAPQVCPLPLNSTTEAV
HMLPHAGAPPLDTVYPAPEKRPSARTQGPVKCESPATTLWAQSELPDFGGNVLLAPAAPALYVCAKPQPPVVQPPEEAMSGQQSRNPSSA
APVQSRGGIGASENLENPPKMGEEEALQSQASSGYASLLSSPPTESLQNPPVLIAQPDHSYNLAQPINFSVSLSNSHEKNQSWREALVGD
RPAVSSWALGGDSGENTSLSGIPTSSVLSLSLPSSVAQSNFPQGSGASEMVSNQPANLLVQPPSQPVPENLVPESQKDRKAGSALPGFAN
SPAGSTSVVLVPPAHGTLVPDGNKANHSSHQEDTYGALDFTLSRTLENPVNVYNPSHSDSLASQQSVASHPRQSGPGAPNLDRFYQQVTK
DAQGQPGLERAQQELVPPQQQASPPQLPKAMFSELSNPESLPAQGQAQNSAQSPASLVLVDAGQQLPPRPPQSSSVSLVSSGSGQAAVPS
EQPWPQPVPALAPGPPPQDLAAYYYYRPLYDAYQPQYSLPYPPEPGAASLYYQDVYSLYEPRYRPYDGAASAYAQNYRYPEPERPSSRAS
HSSERPPPRQGYPEGYYSSKSGWSSQSDYYASYYSSQYDYGDPGHWDRYHYSARVRDPRTYDRRYWCDAEYDAYRREHSAFGDRPEKRDN
NWRYDPRFTGSFDDDPDPHRDPYGEEVDRRSVHSEHSARSLHSAHSLASRRSSLSSHSHQSQIYRSHNVAAGSYEAPLPPGSFHGDFAYG
TYRSNFSSGPGFPEYGYPADTVWPAMEQVSSRPTSPEKFSVPHVCARFGPGGQLIKVIPNLPSEGQPALVEVHSMEALLQHTSEQEEMRA
FPGPLAKDDTHKVDVINFAQNKAMKCLQNENLIDKESASLLWNFIVLLCRQNGTVVGTDIAELLLRDHRTVWLPGKSPNEANLIDFTNEA
VEQVEEEESGEAQLSFLTGGPAAAASSLERETERFRELLLYGRKKDALESAMKNGLWGHALLLASKMDSRTHARVMTRFANSLPINDPLQ
TVYQLMSGRMPAASTCCGDEKWGDWRPHLAMVLSNLNNNMDVESRTMATMGDTLASRGLLDAAHFCYLMAQAGFGVYTKKTTKLVLIGSN
HSLPFLKFATNEAIQRTEAYEYAQSLGAETCPLPSFQVFKFIYSCRLAEMGLATQAFHYCEAIAKSILTQPHLYSPVLISQLVQMASQLR
LFDPQLKEKPEEESLAAPTWLVHLQQVERQIKEGAGVWHQDGALPQQCPGTPSSEMEQLDRPGLSQPGALGIANPLLAVPAPSPEHSSPS
VRLLPSAPQTLPDGPLASPARVPMFPVPLPPGPLEPGPGCVTPGPALGFLEPSGPGLPPGVPPLQERRHLLQEARSPDPGIVPQEAPVGN
SLSELSEENFDGKFANLTPSRTVPDSEAPPGWDRADSGPTQPPLSLSPAPETKRPGQAAKKETKEPKKGESWFFRWLPGKKKTEAYLPDD
KNKSIVWDEKKNQWVNLNEPEEEKKAPPPPPTSMPKTVQAAPPALPGPPGAPVNMYSRRAAGTRARYVDVLNPSGTQRSEPALAPADFVA
PLAPLPIPSNLFVPTPDAEEPQLPDGTGREGPAAARGLANPEPAPEPKVLSSAASLPGSELPSSRPEGSQGGELSRCSSMSSLSREVSQH

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Fusion Gene PPI Analysis for RAPGEF1-SEC16A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	SEC16A	chr9:134615157	chr9:139372136	ENST00000290037		0	29	1101_1400	0.0	2160.0	MIA3
Tgene	SEC16A	chr9:134615157	chr9:139372136	ENST00000371706		0	28	1101_1400	0	2135.0	MIA3
Tgene	SEC16A	chr9:134615157	chr9:139372136	ENST00000431893		0	29	1101_1400	0.0	2155.0	MIA3

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for RAPGEF1-SEC16A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for RAPGEF1-SEC16A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source