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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAPGEF6-DDX46 (FusionGDB2 ID:72258)

Fusion Gene Summary for RAPGEF6-DDX46

check button Fusion gene summary
Fusion gene informationFusion gene name: RAPGEF6-DDX46
Fusion gene ID: 72258
HgeneTgene
Gene symbol

RAPGEF6

DDX46

Gene ID

51735

9879

Gene nameRap guanine nucleotide exchange factor 6DEAD-box helicase 46
SynonymsKIA001LB|PDZ-GEF2|PDZGEF2|RA-GEF-2|RAGEF2PRPF5|Prp5
Cytomap

5q31.1

5q31.1

Type of geneprotein-codingprotein-coding
Descriptionrap guanine nucleotide exchange factor 6PDZ domain containing guanine nucleotide exchange factor (GEF) 2PDZ domain-containing guanine nucleotide exchange factor 2PDZ domain-containing guanine nucleotide exchange factor IRap guanine nucleotide exchangeprobable ATP-dependent RNA helicase DDX46DEAD (Asp-Glu-Ala-Asp) box polypeptide 46DEAD box protein 46PRP5 homologPrp5-like DEAD-box proteinRNA helicase
Modification date2020031320200313
UniProtAcc.

Q7L014

Ensembl transtripts involved in fusion geneENST00000296859, ENST00000307984, 
ENST00000308008, ENST00000507093, 
ENST00000509018, ENST00000510071, 
ENST00000503398, ENST00000512052, 
ENST00000509178, ENST00000354283, 
ENST00000452510, 
Fusion gene scores* DoF score10 X 10 X 6=60011 X 9 X 6=594
# samples 1012
** MAII scorelog2(10/600*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/594*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAPGEF6 [Title/Abstract] AND DDX46 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAPGEF6(130883740)-DDX46(134130540), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RAPGEF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DDX46 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GY-01ARAPGEF6chr5

130883740

-DDX46chr5

134130540

+


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Fusion Gene ORF analysis for RAPGEF6-DDX46

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000296859ENST00000509178RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
5CDS-3UTRENST00000307984ENST00000509178RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
5CDS-3UTRENST00000308008ENST00000509178RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
5CDS-3UTRENST00000507093ENST00000509178RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
5CDS-3UTRENST00000509018ENST00000509178RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
5CDS-3UTRENST00000510071ENST00000509178RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
In-frameENST00000296859ENST00000354283RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
In-frameENST00000296859ENST00000452510RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
In-frameENST00000307984ENST00000354283RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
In-frameENST00000307984ENST00000452510RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
In-frameENST00000308008ENST00000354283RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
In-frameENST00000308008ENST00000452510RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
In-frameENST00000507093ENST00000354283RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
In-frameENST00000507093ENST00000452510RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
In-frameENST00000509018ENST00000354283RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
In-frameENST00000509018ENST00000452510RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
In-frameENST00000510071ENST00000354283RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
In-frameENST00000510071ENST00000452510RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
intron-3CDSENST00000503398ENST00000354283RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
intron-3CDSENST00000503398ENST00000452510RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
intron-3CDSENST00000512052ENST00000354283RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
intron-3CDSENST00000512052ENST00000452510RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
intron-3UTRENST00000503398ENST00000509178RAPGEF6chr5

130883740

-DDX46chr5

134130540

+
intron-3UTRENST00000512052ENST00000509178RAPGEF6chr5

130883740

-DDX46chr5

134130540

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000509018RAPGEF6chr5130883740-ENST00000452510DDX46chr5134130540+46067011822173663
ENST00000509018RAPGEF6chr5130883740-ENST00000354283DDX46chr5134130540+27617011822170662
ENST00000307984RAPGEF6chr5130883740-ENST00000452510DDX46chr5134130540+46067011822173663
ENST00000307984RAPGEF6chr5130883740-ENST00000354283DDX46chr5134130540+27617011822170662
ENST00000507093RAPGEF6chr5130883740-ENST00000452510DDX46chr5134130540+45826771582149663
ENST00000507093RAPGEF6chr5130883740-ENST00000354283DDX46chr5134130540+27376771582146662
ENST00000296859RAPGEF6chr5130883740-ENST00000452510DDX46chr5134130540+4481576572048663
ENST00000296859RAPGEF6chr5130883740-ENST00000354283DDX46chr5134130540+2636576572045662
ENST00000308008RAPGEF6chr5130883740-ENST00000452510DDX46chr5134130540+440049501967655
ENST00000308008RAPGEF6chr5130883740-ENST00000354283DDX46chr5134130540+255549501964654
ENST00000510071RAPGEF6chr5130883740-ENST00000452510DDX46chr5134130540+46016961772168663
ENST00000510071RAPGEF6chr5130883740-ENST00000354283DDX46chr5134130540+27566961772165662

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000509018ENST00000452510RAPGEF6chr5130883740-DDX46chr5134130540+0.0004455650.99955446
ENST00000509018ENST00000354283RAPGEF6chr5130883740-DDX46chr5134130540+0.0012704770.9987295
ENST00000307984ENST00000452510RAPGEF6chr5130883740-DDX46chr5134130540+0.0004455650.99955446
ENST00000307984ENST00000354283RAPGEF6chr5130883740-DDX46chr5134130540+0.0012704770.9987295
ENST00000507093ENST00000452510RAPGEF6chr5130883740-DDX46chr5134130540+0.0004449810.99955505
ENST00000507093ENST00000354283RAPGEF6chr5130883740-DDX46chr5134130540+0.0012602790.9987398
ENST00000296859ENST00000452510RAPGEF6chr5130883740-DDX46chr5134130540+0.0004526910.9995473
ENST00000296859ENST00000354283RAPGEF6chr5130883740-DDX46chr5134130540+0.0014072450.9985928
ENST00000308008ENST00000452510RAPGEF6chr5130883740-DDX46chr5134130540+0.0004609010.99953914
ENST00000308008ENST00000354283RAPGEF6chr5130883740-DDX46chr5134130540+0.0015084310.9984915
ENST00000510071ENST00000452510RAPGEF6chr5130883740-DDX46chr5134130540+0.0004499760.99955004
ENST00000510071ENST00000354283RAPGEF6chr5130883740-DDX46chr5134130540+0.001312940.9986871

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Fusion Genomic Features for RAPGEF6-DDX46


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RAPGEF6chr5130883739-DDX46chr5134130539+2.72E-121
RAPGEF6chr5130883739-DDX46chr5134130539+2.72E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RAPGEF6-DDX46


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:130883740/chr5:134130540)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DDX46

Q7L014

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays an essential role in splicing, either prior to, or during splicing A complex formation. {ECO:0000269|PubMed:12234937}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDDX46chr5:130883740chr5:134130540ENST000003542831223592_7535421032.0DomainHelicase C-terminal
TgeneDDX46chr5:130883740chr5:134130540ENST000004525101223592_7535421033.0DomainHelicase C-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000296859-6291229_14401651610.0Compositional biasNote=Ser-rich
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000307984-6291229_14401651510.0Compositional biasNote=Ser-rich
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000308008-6251229_14401651392.0Compositional biasNote=Ser-rich
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000507093-6281229_14401651505.0Compositional biasNote=Ser-rich
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000509018-6281229_14401651602.0Compositional biasNote=Ser-rich
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000510071-6181229_1440165828.0Compositional biasNote=Ser-rich
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000296859-629412_5261651610.0DomainN-terminal Ras-GEF
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000296859-629530_6151651610.0DomainPDZ
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000296859-629749_8351651610.0DomainRas-associating
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000296859-629860_10881651610.0DomainRas-GEF
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000307984-629412_5261651510.0DomainN-terminal Ras-GEF
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000307984-629530_6151651510.0DomainPDZ
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000307984-629749_8351651510.0DomainRas-associating
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000307984-629860_10881651510.0DomainRas-GEF
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000308008-625412_5261651392.0DomainN-terminal Ras-GEF
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000308008-625530_6151651392.0DomainPDZ
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000308008-625749_8351651392.0DomainRas-associating
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000308008-625860_10881651392.0DomainRas-GEF
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000507093-628412_5261651505.0DomainN-terminal Ras-GEF
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000507093-628530_6151651505.0DomainPDZ
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000507093-628749_8351651505.0DomainRas-associating
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000507093-628860_10881651505.0DomainRas-GEF
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000509018-628412_5261651602.0DomainN-terminal Ras-GEF
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000509018-628530_6151651602.0DomainPDZ
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000509018-628749_8351651602.0DomainRas-associating
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000509018-628860_10881651602.0DomainRas-GEF
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000510071-618412_526165828.0DomainN-terminal Ras-GEF
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000510071-618530_615165828.0DomainPDZ
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000510071-618749_835165828.0DomainRas-associating
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000510071-618860_1088165828.0DomainRas-GEF
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000296859-629280_3991651610.0Nucleotide bindingNote=cNMP
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000307984-629280_3991651510.0Nucleotide bindingNote=cNMP
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000308008-625280_3991651392.0Nucleotide bindingNote=cNMP
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000507093-628280_3991651505.0Nucleotide bindingNote=cNMP
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000509018-628280_3991651602.0Nucleotide bindingNote=cNMP
HgeneRAPGEF6chr5:130883740chr5:134130540ENST00000510071-618280_399165828.0Nucleotide bindingNote=cNMP
TgeneDDX46chr5:130883740chr5:134130540ENST000003542831223152_1975421032.0Coiled coilOntology_term=ECO:0000255
TgeneDDX46chr5:130883740chr5:134130540ENST000004525101223152_1975421033.0Coiled coilOntology_term=ECO:0000255
TgeneDDX46chr5:130883740chr5:134130540ENST000003542831223202_2095421032.0Compositional biasNote=Poly-Asp
TgeneDDX46chr5:130883740chr5:134130540ENST0000035428312233_1035421032.0Compositional biasNote=Arg-rich
TgeneDDX46chr5:130883740chr5:134130540ENST000004525101223202_2095421033.0Compositional biasNote=Poly-Asp
TgeneDDX46chr5:130883740chr5:134130540ENST0000045251012233_1035421033.0Compositional biasNote=Arg-rich
TgeneDDX46chr5:130883740chr5:134130540ENST000003542831223403_5815421032.0DomainHelicase ATP-binding
TgeneDDX46chr5:130883740chr5:134130540ENST000004525101223403_5815421033.0DomainHelicase ATP-binding
TgeneDDX46chr5:130883740chr5:134130540ENST000003542831223372_4005421032.0MotifNote=Q motif
TgeneDDX46chr5:130883740chr5:134130540ENST000003542831223529_5325421032.0MotifNote=DEAD box
TgeneDDX46chr5:130883740chr5:134130540ENST000004525101223372_4005421033.0MotifNote=Q motif
TgeneDDX46chr5:130883740chr5:134130540ENST000004525101223529_5325421033.0MotifNote=DEAD box
TgeneDDX46chr5:130883740chr5:134130540ENST000003542831223416_4235421032.0Nucleotide bindingATP
TgeneDDX46chr5:130883740chr5:134130540ENST000004525101223416_4235421033.0Nucleotide bindingATP


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Fusion Gene Sequence for RAPGEF6-DDX46


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72258_72258_1_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000296859_DDX46_chr5_134130540_ENST00000354283_length(transcript)=2636nt_BP=576nt
GGTACCGCACCCGCTACCTAGTGTGAATGAACTGTGGCGTGGGCTGCTAAGGGCAGGCTGCGGAGTACCCGGGCCGTGGCCATGAACTCA
CCCGTGGACCCTGGCGCTAGGCAGGCGTTGAGGAAGAAGCCACCCGAGCGGACTCCCGAGGACTTAAATACTATTTATTCTTATCTTCAT
GGAATGGAAATATTATCAAATCTCAGGGAACATCAGCTTAGATTAATGTCTGCAAGAGCACGCTATGAGAGATACAGTGGCAATCAGGTT
CTCTTTTGTTCAGAAACGATTGCCAGATGTTGGTATATCCTACTTTCTGGATCTGTGCTTGTGAAAGGCTCCATGGTCTTGCCTCCTTGC
AGTTTTGGTAAGCAGTTTGGAGGAAAAAGAGGATGTGATTGTCTTGTATTAGAGCCTTCAGAAATGATTGTGGTAGAGAATGCCAAAGAT
AATGAAGATAGTATTCTACAAAGAGAAATTCCTGCCAGACAATCCCGAAGAAGATTTCGGAAAATTAACTATAAAGGAGAGCGCCAAACC
ATTACTGATGATGTGGAGGTTAACAGCTATCTTTCTGTCATGCGCATCGTGGATAATGTTCGTCCTGATCGACAGACGGTTATGTTTTCA
GCTACTTTCCCCAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTATTGAAGTACAAGTTGGAGGCAGGAGTGTGGTTTGC
TCAGATGTGGAGCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTTCTAGGCCATTATCAAGAGTCAGGA
TCTGTCATTATATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATTTAATGAGAGCATCTTATCCTTGCATGTCTCTTCAT
GGAGGCATTGATCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGACCTGCAAACTTCTTGTGGCTACCTCTGTTGCTGCC
CGAGGTCTAGATGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACCATTATGAGGATTATGTACACAGAGCAGGGCGGACT
GGAAGAGCAGGAAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTCGCTATGCTGGTGACATAATTAAAGCTCTTGAATTG
TCAGGGACTGCAGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCTGAGGGGAAAATAATTAAAAAGAGT
AGTGGGTTCTCTGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTAATGAGAGGAAGAAGTTACAAAAAGCAGCTCTTGGT
CTACAAGATTCAGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAAGCATGTTTAATTCAAAGAAGAGAGTAAAGGATATG
GCTGCTCCTGGAACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAATTAGAAATTGCTAAGAGATTGGCTCTTAGAATCAAT
GCCCAGAAGAATTTGGGCATCGAGTCTCAGGATGTGATGCAGCAGGCCACCAATGCAATTCTTAGGGGTGGCACCATTCTGGCTCCCACT
GTTTCTGCAAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCAATTATGTGCCGTTAGAGAAACAAGAAGAAGAGAGA
CAGGATGGTGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCAATGACTTCCCACAGACTGCTAGGTGGAAAGTTACC
TCTAAGGAAGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCAGAGGAACCTACTTCCCTCCTGGCAAAGAACCCAAG
GAAGGCGAGCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAGGCAGAAATCACCAGGCTCATAAAA
GAAGAGCTGATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACAAAGTCTTATAGACATCCGGAAAAAAGATTTTTACC
TGTGCTGGTCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGTAAATGAAGATTTTTTAAATTCTATCTTGCTGATTT
TTTTTAAATATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCCACAATCAGTCAAACTATATTTAAAGCCAGCCTGTT
TTCAGAGTATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCGGATAATATTCTAGAGGTTTAAAAAATGGAAATATT
TGAACTTTCTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTTTATCCTGTACTTTCAATGAAATTGTGATCATTTCC
TAAGAAAAGGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATGACTCTGGAACAATATGAACTGGATTTAAGAATGTT
ATAATAGAAGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCATAAATGGGCAAAAAGTAGTTGGACTAATTTCGGTT

>72258_72258_1_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000296859_DDX46_chr5_134130540_ENST00000354283_length(amino acids)=662AA_BP=173
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSVMRIVDN
VRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDL
MRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQAR
YAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIES
MFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLN
YVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQ

--------------------------------------------------------------
>72258_72258_2_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000296859_DDX46_chr5_134130540_ENST00000452510_length(transcript)=4481nt_BP=576nt
GGTACCGCACCCGCTACCTAGTGTGAATGAACTGTGGCGTGGGCTGCTAAGGGCAGGCTGCGGAGTACCCGGGCCGTGGCCATGAACTCA
CCCGTGGACCCTGGCGCTAGGCAGGCGTTGAGGAAGAAGCCACCCGAGCGGACTCCCGAGGACTTAAATACTATTTATTCTTATCTTCAT
GGAATGGAAATATTATCAAATCTCAGGGAACATCAGCTTAGATTAATGTCTGCAAGAGCACGCTATGAGAGATACAGTGGCAATCAGGTT
CTCTTTTGTTCAGAAACGATTGCCAGATGTTGGTATATCCTACTTTCTGGATCTGTGCTTGTGAAAGGCTCCATGGTCTTGCCTCCTTGC
AGTTTTGGTAAGCAGTTTGGAGGAAAAAGAGGATGTGATTGTCTTGTATTAGAGCCTTCAGAAATGATTGTGGTAGAGAATGCCAAAGAT
AATGAAGATAGTATTCTACAAAGAGAAATTCCTGCCAGACAATCCCGAAGAAGATTTCGGAAAATTAACTATAAAGGAGAGCGCCAAACC
ATTACTGATGATGTGGAGGTTAACAGCTATCTTTCTGTCATGCGCATCGTGGATAATGTTCGTCCTGATCGACAGACGGTTATGTTTTCA
GCTACTTTCCCCAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTATTGAAGTACAAGTTGGAGGCAGGAGTGTGGTTTGC
TCAGATGTGGAGCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTTCTAGGCCATTATCAAGAGTCAGGA
TCTGTCATTATATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATTTAATGAGAGCATCTTATCCTTGCATGTCTCTTCAT
GGAGGCATTGATCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGACCTGCAAACTTCTTGTGGCTACCTCTGTTGCTGCC
CGAGGTCTAGATGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACCATTATGAGGATTATGTACACAGAGCAGGGCGGACT
GGAAGAGCAGGAAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTCGCTATGCTGGTGACATAATTAAAGCTCTTGAATTG
TCAGGGACTGCAGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCTGAGGGGAAAATAATTAAAAAGAGT
AGTGGGTTCTCTGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTAATGAGAGGAAGAAGTTACAAAAAGCAGCTCTTGGT
CTACAAGATTCAGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAAGCATGTTTAATTCAAAGAAGAGAGTAAAGGATATG
GCTGCTCCTGGAACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAATTAGAAATTGCTAAGAGATTGGCTCTTAGAATCAAT
GCCCAGAAGAATTTGGGCATCGAGTCTCAGGTAGATGTGATGCAGCAGGCCACCAATGCAATTCTTAGGGGTGGCACCATTCTGGCTCCC
ACTGTTTCTGCAAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCAATTATGTGCCGTTAGAGAAACAAGAAGAAGAG
AGACAGGATGGTGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCAATGACTTCCCACAGACTGCTAGGTGGAAAGTT
ACCTCTAAGGAAGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCAGAGGAACCTACTTCCCTCCTGGCAAAGAACCC
AAGGAAGGCGAGCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAGGCAGAAATCACCAGGCTCATA
AAAGAAGAGCTGATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACAAAGTCTTATAGACATCCGGAAAAAAGATTTTT
ACCTGTGCTGGTCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGTAAATGAAGATTTTTTAAATTCTATCTTGCTGA
TTTTTTTTAAATATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCCACAATCAGTCAAACTATATTTAAAGCCAGCCT
GTTTTCAGAGTATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCGGATAATATTCTAGAGGTTTAAAAAATGGAAAT
ATTTGAACTTTCTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTTTATCCTGTACTTTCAATGAAATTGTGATCATT
TCCTAAGAAAAGGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATGACTCTGGAACAATATGAACTGGATTTAAGAAT
GTTATAATAGAAGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCATAAATGGGCAAAAAGTAGTTGGACTAATTTCG
GTTTTTATACAAGTAAAGATTTAATAGTATAAGGATTTTTTTGCATTTCTTTACACTGAGTGTAAAACTCTACAAAGAGTTATAGTATTT
ACTACTTTGAGGTTTCCCTCACAACTTCTGGCTCCATACCTAGCCCCTCTTTTATAATCTTCCTTAAAAGAAAGAGTGTAGCCTATAAAT
ACTAAATATGATACCTTTTCCTTCTAGAAAGTGTTTATTTATATATCTATACATGTTGTATGTACAAATATCCTACTACTTTTAATCTGA
TTTTTCTTCAGGATTATTGAGTAGGTTGTGAATTTTCTTTCTTAAAAATTGTAAAACATAATGGTACCCAAGTTTTAAACTTAGATGTGC
TTCATCTTAGTGAAATTTAATTCACAAGGAATCATAAATTGTGTTTTTGAGGCTGGGCGCAGTGACTCACACCTGTATCCCAGCAATTTG
GGAGGCCGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAA
AATTAGTCGGCATGGTGGTGGGTGGCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCTGAGCCAAGATAACACCATTGCACT
CCAGCCTGGGCGACAGAGTGAGACTATCTCAAAAATAAATAAATAAATAAATAAATAGTATTTTTGAGCCTTCAAGATACAGTTCCTGAA
TATTCTAATTTAAATTGTTATAATTGGATTACCTAATATTCTTTTCAAGACTCCTGATGTATTAACTTCATGTTATTGTCACTTTTCAAA
AAAGGAATTTTTTTCAGGAGTTAAATAAAGTCAGTCTTTTATATCCAAGGGTTTCAAACCCACAGATTAAACCAACCACAGATCAAAAAT
AGAAAAAAAAAAAAAAAGAAAAAAAGAATGTAAAATTTTAAAAATACAGTTTAACAGCTGTAAAAGTTTTACTATAACATTTACATTGTG
TTAGGTATTTTAAGTAATTTAAAGGTTACAGTATACAGGCGGTTAAAGTATACAGGAGGATGTGCATCGGTTATATGCATATAGCAAGCC
ATTTCATATAAGAGGCTTGAACATCCATGGATTTTGGTATAGAGGAGGGGTTTAAGGGGTGTCCTGCAATCAGTCCCCCTCTCATACCAA
AGGATGACTGTATATTTCTTAAATGAAGAGACTTTCATTCTTTAAATATTATTGACTTACAGTTTAAAAATAAATAAATAAAAGCATACT
ATAGTTGTAAAAACAAATAATTTTAATAGTATATTCAGTGGCTGAAGTGATAGGGAGTATTAATCATTATTTCTTCAGTATAAAGTTATT
CTTCCTGAAAAAGTAAGATATACCTGGGAAATATTCTTGGATCCTTCACACATCCACTTAATTTCTTGAAGGAAGAAAACAGACAAAAGA
CATGTAACAACAGAAACAAATAAACCACTTACTGTAAAATTTCAGAAATTGTGGGCTCATTCCCTCCCTCTAGTTTATTTATTTGCTCAT
CTTTATCACCTAATGGTAGTTTGTTTTCTTTGGTAGAGTATATGGCAGTCCCACATCGATGATAATTGGTGCTCCCTTCATCCAACTGGA
TCACTTTGAGATTCAGTTTTACATCATTTTAGCATTTTGTTTGTATATCAGTTGTGATGAGCCACTGATAAAATTTTGTTCTAAAATGAA
ACATATTACTTTGTTAGTACATTTTTTAGTGTCACACTGACTTTTAAAATTTGAATGATATATAGACTTTGTTTTTTTAATGCAATATGA

>72258_72258_2_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000296859_DDX46_chr5_134130540_ENST00000452510_length(amino acids)=663AA_BP=173
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSVMRIVDN
VRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDL
MRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQAR
YAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIES
MFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKL
NYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAV

--------------------------------------------------------------
>72258_72258_3_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000307984_DDX46_chr5_134130540_ENST00000354283_length(transcript)=2761nt_BP=701nt
CCCGCGCAGACTTGTCTCCGGCCAGTCGCGCGTGGGTAGAGGCCTTAGGCGGGCGTTGCGAAGGGTTGTTTGCTAGAGTTCGGACCTTGT
TACGGCGCGAAGTTCCCTCCTTGGGGCGGGGGAAAGGTACCGCACCCGCTACCTAGTGTGAATGAACTGTGGCGTGGGCTGCTAAGGGCA
GGCTGCGGAGTACCCGGGCCGTGGCCATGAACTCACCCGTGGACCCTGGCGCTAGGCAGGCGTTGAGGAAGAAGCCACCCGAGCGGACTC
CCGAGGACTTAAATACTATTTATTCTTATCTTCATGGAATGGAAATATTATCAAATCTCAGGGAACATCAGCTTAGATTAATGTCTGCAA
GAGCACGCTATGAGAGATACAGTGGCAATCAGGTTCTCTTTTGTTCAGAAACGATTGCCAGATGTTGGTATATCCTACTTTCTGGATCTG
TGCTTGTGAAAGGCTCCATGGTCTTGCCTCCTTGCAGTTTTGGTAAGCAGTTTGGAGGAAAAAGAGGATGTGATTGTCTTGTATTAGAGC
CTTCAGAAATGATTGTGGTAGAGAATGCCAAAGATAATGAAGATAGTATTCTACAAAGAGAAATTCCTGCCAGACAATCCCGAAGAAGAT
TTCGGAAAATTAACTATAAAGGAGAGCGCCAAACCATTACTGATGATGTGGAGGTTAACAGCTATCTTTCTGTCATGCGCATCGTGGATA
ATGTTCGTCCTGATCGACAGACGGTTATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTA
TTGAAGTACAAGTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGT
TACTTGAGCTTCTAGGCCATTATCAAGAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATT
TAATGAGAGCATCTTATCCTTGCATGTCTCTTCATGGAGGCATTGATCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGA
CCTGCAAACTTCTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACC
ATTATGAGGATTATGTACACAGAGCAGGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTC
GCTATGCTGGTGACATAATTAAAGCTCTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATC
AGCAGAAAGCTGAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTA
ATGAGAGGAAGAAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAA
GCATGTTTAATTCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAAT
TAGAAATTGCTAAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTCAGGATGTGATGCAGCAGGCCACCAATG
CAATTCTTAGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCA
ATTATGTGCCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCA
ATGACTTCCCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCA
GAGGAACCTACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGC
AGAAAGCAAAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACA
AAGTCTTATAGACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGT
AAATGAAGATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCC
ACAATCAGTCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCG
GATAATATTCTAGAGGTTTAAAAAATGGAAATATTTGAACTTTCTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTT
TATCCTGTACTTTCAATGAAATTGTGATCATTTCCTAAGAAAAGGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATG
ACTCTGGAACAATATGAACTGGATTTAAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCA

>72258_72258_3_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000307984_DDX46_chr5_134130540_ENST00000354283_length(amino acids)=662AA_BP=173
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSVMRIVDN
VRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDL
MRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQAR
YAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIES
MFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLN
YVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQ

--------------------------------------------------------------
>72258_72258_4_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000307984_DDX46_chr5_134130540_ENST00000452510_length(transcript)=4606nt_BP=701nt
CCCGCGCAGACTTGTCTCCGGCCAGTCGCGCGTGGGTAGAGGCCTTAGGCGGGCGTTGCGAAGGGTTGTTTGCTAGAGTTCGGACCTTGT
TACGGCGCGAAGTTCCCTCCTTGGGGCGGGGGAAAGGTACCGCACCCGCTACCTAGTGTGAATGAACTGTGGCGTGGGCTGCTAAGGGCA
GGCTGCGGAGTACCCGGGCCGTGGCCATGAACTCACCCGTGGACCCTGGCGCTAGGCAGGCGTTGAGGAAGAAGCCACCCGAGCGGACTC
CCGAGGACTTAAATACTATTTATTCTTATCTTCATGGAATGGAAATATTATCAAATCTCAGGGAACATCAGCTTAGATTAATGTCTGCAA
GAGCACGCTATGAGAGATACAGTGGCAATCAGGTTCTCTTTTGTTCAGAAACGATTGCCAGATGTTGGTATATCCTACTTTCTGGATCTG
TGCTTGTGAAAGGCTCCATGGTCTTGCCTCCTTGCAGTTTTGGTAAGCAGTTTGGAGGAAAAAGAGGATGTGATTGTCTTGTATTAGAGC
CTTCAGAAATGATTGTGGTAGAGAATGCCAAAGATAATGAAGATAGTATTCTACAAAGAGAAATTCCTGCCAGACAATCCCGAAGAAGAT
TTCGGAAAATTAACTATAAAGGAGAGCGCCAAACCATTACTGATGATGTGGAGGTTAACAGCTATCTTTCTGTCATGCGCATCGTGGATA
ATGTTCGTCCTGATCGACAGACGGTTATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTA
TTGAAGTACAAGTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGT
TACTTGAGCTTCTAGGCCATTATCAAGAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATT
TAATGAGAGCATCTTATCCTTGCATGTCTCTTCATGGAGGCATTGATCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGA
CCTGCAAACTTCTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACC
ATTATGAGGATTATGTACACAGAGCAGGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTC
GCTATGCTGGTGACATAATTAAAGCTCTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATC
AGCAGAAAGCTGAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTA
ATGAGAGGAAGAAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAA
GCATGTTTAATTCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAAT
TAGAAATTGCTAAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTCAGGTAGATGTGATGCAGCAGGCCACCA
ATGCAATTCTTAGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGC
TCAATTATGTGCCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGA
TCAATGACTTCCCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAA
TCAGAGGAACCTACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTG
TGCAGAAAGCAAAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGAT
ACAAAGTCTTATAGACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTAT
TGTAAATGAAGATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACC
CCCACAATCAGTCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGT
CCGGATAATATTCTAGAGGTTTAAAAAATGGAAATATTTGAACTTTCTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCA
CTTTATCCTGTACTTTCAATGAAATTGTGATCATTTCCTAAGAAAAGGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTAC
ATGACTCTGGAACAATATGAACTGGATTTAAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCA
TCATAAATGGGCAAAAAGTAGTTGGACTAATTTCGGTTTTTATACAAGTAAAGATTTAATAGTATAAGGATTTTTTTGCATTTCTTTACA
CTGAGTGTAAAACTCTACAAAGAGTTATAGTATTTACTACTTTGAGGTTTCCCTCACAACTTCTGGCTCCATACCTAGCCCCTCTTTTAT
AATCTTCCTTAAAAGAAAGAGTGTAGCCTATAAATACTAAATATGATACCTTTTCCTTCTAGAAAGTGTTTATTTATATATCTATACATG
TTGTATGTACAAATATCCTACTACTTTTAATCTGATTTTTCTTCAGGATTATTGAGTAGGTTGTGAATTTTCTTTCTTAAAAATTGTAAA
ACATAATGGTACCCAAGTTTTAAACTTAGATGTGCTTCATCTTAGTGAAATTTAATTCACAAGGAATCATAAATTGTGTTTTTGAGGCTG
GGCGCAGTGACTCACACCTGTATCCCAGCAATTTGGGAGGCCGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCAAGACTAGCCTGGTCA
ACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGTCGGCATGGTGGTGGGTGGCTGTAATCCCAGCTACTCAGGAGGCTGAGG
CAGAAGAATCTGAGCCAAGATAACACCATTGCACTCCAGCCTGGGCGACAGAGTGAGACTATCTCAAAAATAAATAAATAAATAAATAAA
TAGTATTTTTGAGCCTTCAAGATACAGTTCCTGAATATTCTAATTTAAATTGTTATAATTGGATTACCTAATATTCTTTTCAAGACTCCT
GATGTATTAACTTCATGTTATTGTCACTTTTCAAAAAAGGAATTTTTTTCAGGAGTTAAATAAAGTCAGTCTTTTATATCCAAGGGTTTC
AAACCCACAGATTAAACCAACCACAGATCAAAAATAGAAAAAAAAAAAAAAAGAAAAAAAGAATGTAAAATTTTAAAAATACAGTTTAAC
AGCTGTAAAAGTTTTACTATAACATTTACATTGTGTTAGGTATTTTAAGTAATTTAAAGGTTACAGTATACAGGCGGTTAAAGTATACAG
GAGGATGTGCATCGGTTATATGCATATAGCAAGCCATTTCATATAAGAGGCTTGAACATCCATGGATTTTGGTATAGAGGAGGGGTTTAA
GGGGTGTCCTGCAATCAGTCCCCCTCTCATACCAAAGGATGACTGTATATTTCTTAAATGAAGAGACTTTCATTCTTTAAATATTATTGA
CTTACAGTTTAAAAATAAATAAATAAAAGCATACTATAGTTGTAAAAACAAATAATTTTAATAGTATATTCAGTGGCTGAAGTGATAGGG
AGTATTAATCATTATTTCTTCAGTATAAAGTTATTCTTCCTGAAAAAGTAAGATATACCTGGGAAATATTCTTGGATCCTTCACACATCC
ACTTAATTTCTTGAAGGAAGAAAACAGACAAAAGACATGTAACAACAGAAACAAATAAACCACTTACTGTAAAATTTCAGAAATTGTGGG
CTCATTCCCTCCCTCTAGTTTATTTATTTGCTCATCTTTATCACCTAATGGTAGTTTGTTTTCTTTGGTAGAGTATATGGCAGTCCCACA
TCGATGATAATTGGTGCTCCCTTCATCCAACTGGATCACTTTGAGATTCAGTTTTACATCATTTTAGCATTTTGTTTGTATATCAGTTGT
GATGAGCCACTGATAAAATTTTGTTCTAAAATGAAACATATTACTTTGTTAGTACATTTTTTAGTGTCACACTGACTTTTAAAATTTGAA
TGATATATAGACTTTGTTTTTTTAATGCAATATGAATATTTGCTCATGTTTTCTAAATTCCTTATAAAATAAAATTAATTCGAATTCAAT

>72258_72258_4_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000307984_DDX46_chr5_134130540_ENST00000452510_length(amino acids)=663AA_BP=173
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSVMRIVDN
VRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDL
MRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQAR
YAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIES
MFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKL
NYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAV

--------------------------------------------------------------
>72258_72258_5_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000308008_DDX46_chr5_134130540_ENST00000354283_length(transcript)=2555nt_BP=495nt
ATGAACTCACCCGTGGACCCTGGCGCTAGGCAGGCGTTGAGGAAGAAGCCACCCGAGCGGACTCCCGAGGACTTAAATACTATTTATTCT
TATCTTCATGGAATGGAAATATTATCAAATCTCAGGGAACATCAGCTTAGATTAATGTCTGCAAGAGCACGCTATGAGAGATACAGTGGC
AATCAGGTTCTCTTTTGTTCAGAAACGATTGCCAGATGTTGGTATATCCTACTTTCTGGATCTGTGCTTGTGAAAGGCTCCATGGTCTTG
CCTCCTTGCAGTTTTGGTAAGCAGTTTGGAGGAAAAAGAGGATGTGATTGTCTTGTATTAGAGCCTTCAGAAATGATTGTGGTAGAGAAT
GCCAAAGATAATGAAGATAGTATTCTACAAAGAGAAATTCCTGCCAGACAATCCCGAAGAAGATTTCGGAAAATTAACTATAAAGGAGAG
CGCCAAACCATTACTGATGATGTGGAGGTTAACAGCTATCTTTCTGTCATGCGCATCGTGGATAATGTTCGTCCTGATCGACAGACGGTT
ATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTATTGAAGTACAAGTTGGAGGCAGGAGT
GTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTTCTAGGCCATTATCAA
GAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATTTAATGAGAGCATCTTATCCTTGCATG
TCTCTTCATGGAGGCATTGATCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGACCTGCAAACTTCTTGTGGCTACCTCT
GTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACCATTATGAGGATTATGTACACAGAGCA
GGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTCGCTATGCTGGTGACATAATTAAAGCT
CTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCTGAGGGGAAAATAATT
AAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTAATGAGAGGAAGAAGTTACAAAAAGCA
GCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAAGCATGTTTAATTCAAAGAAGAGAGTA
AAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAATTAGAAATTGCTAAGAGATTGGCTCTT
AGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTCAGGATGTGATGCAGCAGGCCACCAATGCAATTCTTAGGGGTGGCACCATTCTG
GCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCAATTATGTGCCGTTAGAGAAACAAGAA
GAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCAATGACTTCCCACAGACTGCTAGGTGG
AAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCAGAGGAACCTACTTCCCTCCTGGCAAA
GAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAGGCAGAAATCACCAGG
CTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACAAAGTCTTATAGACATCCGGAAAAAAG
ATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGTAAATGAAGATTTTTTAAATTCTATCT
TGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCCACAATCAGTCAAACTATATTTAAAGC
CAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCGGATAATATTCTAGAGGTTTAAAAAAT
GGAAATATTTGAACTTTCTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTTTATCCTGTACTTTCAATGAAATTGTG
ATCATTTCCTAAGAAAAGGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATGACTCTGGAACAATATGAACTGGATTT
AAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCATAAATGGGCAAAAAGTAGTTGGACTA

>72258_72258_5_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000308008_DDX46_chr5_134130540_ENST00000354283_length(amino acids)=654AA_BP=165
MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVLVKGSMVL
PPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSVMRIVDNVRPDRQTV
MFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCM
SLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKA
LELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESMFNSKKRV
KDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLNYVPLEKQE
EERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQKAKAEITR

--------------------------------------------------------------
>72258_72258_6_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000308008_DDX46_chr5_134130540_ENST00000452510_length(transcript)=4400nt_BP=495nt
ATGAACTCACCCGTGGACCCTGGCGCTAGGCAGGCGTTGAGGAAGAAGCCACCCGAGCGGACTCCCGAGGACTTAAATACTATTTATTCT
TATCTTCATGGAATGGAAATATTATCAAATCTCAGGGAACATCAGCTTAGATTAATGTCTGCAAGAGCACGCTATGAGAGATACAGTGGC
AATCAGGTTCTCTTTTGTTCAGAAACGATTGCCAGATGTTGGTATATCCTACTTTCTGGATCTGTGCTTGTGAAAGGCTCCATGGTCTTG
CCTCCTTGCAGTTTTGGTAAGCAGTTTGGAGGAAAAAGAGGATGTGATTGTCTTGTATTAGAGCCTTCAGAAATGATTGTGGTAGAGAAT
GCCAAAGATAATGAAGATAGTATTCTACAAAGAGAAATTCCTGCCAGACAATCCCGAAGAAGATTTCGGAAAATTAACTATAAAGGAGAG
CGCCAAACCATTACTGATGATGTGGAGGTTAACAGCTATCTTTCTGTCATGCGCATCGTGGATAATGTTCGTCCTGATCGACAGACGGTT
ATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTATTGAAGTACAAGTTGGAGGCAGGAGT
GTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTTCTAGGCCATTATCAA
GAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATTTAATGAGAGCATCTTATCCTTGCATG
TCTCTTCATGGAGGCATTGATCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGACCTGCAAACTTCTTGTGGCTACCTCT
GTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACCATTATGAGGATTATGTACACAGAGCA
GGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTCGCTATGCTGGTGACATAATTAAAGCT
CTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCTGAGGGGAAAATAATT
AAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTAATGAGAGGAAGAAGTTACAAAAAGCA
GCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAAGCATGTTTAATTCAAAGAAGAGAGTA
AAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAATTAGAAATTGCTAAGAGATTGGCTCTT
AGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTCAGGTAGATGTGATGCAGCAGGCCACCAATGCAATTCTTAGGGGTGGCACCATT
CTGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCAATTATGTGCCGTTAGAGAAACAA
GAAGAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCAATGACTTCCCACAGACTGCTAGG
TGGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCAGAGGAACCTACTTCCCTCCTGGC
AAAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAGGCAGAAATCACC
AGGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACAAAGTCTTATAGACATCCGGAAAA
AAGATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGTAAATGAAGATTTTTTAAATTCTA
TCTTGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCCACAATCAGTCAAACTATATTTAA
AGCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCGGATAATATTCTAGAGGTTTAAAA
AATGGAAATATTTGAACTTTCTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTTTATCCTGTACTTTCAATGAAATT
GTGATCATTTCCTAAGAAAAGGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATGACTCTGGAACAATATGAACTGGA
TTTAAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCATAAATGGGCAAAAAGTAGTTGGA
CTAATTTCGGTTTTTATACAAGTAAAGATTTAATAGTATAAGGATTTTTTTGCATTTCTTTACACTGAGTGTAAAACTCTACAAAGAGTT
ATAGTATTTACTACTTTGAGGTTTCCCTCACAACTTCTGGCTCCATACCTAGCCCCTCTTTTATAATCTTCCTTAAAAGAAAGAGTGTAG
CCTATAAATACTAAATATGATACCTTTTCCTTCTAGAAAGTGTTTATTTATATATCTATACATGTTGTATGTACAAATATCCTACTACTT
TTAATCTGATTTTTCTTCAGGATTATTGAGTAGGTTGTGAATTTTCTTTCTTAAAAATTGTAAAACATAATGGTACCCAAGTTTTAAACT
TAGATGTGCTTCATCTTAGTGAAATTTAATTCACAAGGAATCATAAATTGTGTTTTTGAGGCTGGGCGCAGTGACTCACACCTGTATCCC
AGCAATTTGGGAGGCCGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCTGTCTCTACTAA
AAATACAAAAATTAGTCGGCATGGTGGTGGGTGGCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCTGAGCCAAGATAACAC
CATTGCACTCCAGCCTGGGCGACAGAGTGAGACTATCTCAAAAATAAATAAATAAATAAATAAATAGTATTTTTGAGCCTTCAAGATACA
GTTCCTGAATATTCTAATTTAAATTGTTATAATTGGATTACCTAATATTCTTTTCAAGACTCCTGATGTATTAACTTCATGTTATTGTCA
CTTTTCAAAAAAGGAATTTTTTTCAGGAGTTAAATAAAGTCAGTCTTTTATATCCAAGGGTTTCAAACCCACAGATTAAACCAACCACAG
ATCAAAAATAGAAAAAAAAAAAAAAAGAAAAAAAGAATGTAAAATTTTAAAAATACAGTTTAACAGCTGTAAAAGTTTTACTATAACATT
TACATTGTGTTAGGTATTTTAAGTAATTTAAAGGTTACAGTATACAGGCGGTTAAAGTATACAGGAGGATGTGCATCGGTTATATGCATA
TAGCAAGCCATTTCATATAAGAGGCTTGAACATCCATGGATTTTGGTATAGAGGAGGGGTTTAAGGGGTGTCCTGCAATCAGTCCCCCTC
TCATACCAAAGGATGACTGTATATTTCTTAAATGAAGAGACTTTCATTCTTTAAATATTATTGACTTACAGTTTAAAAATAAATAAATAA
AAGCATACTATAGTTGTAAAAACAAATAATTTTAATAGTATATTCAGTGGCTGAAGTGATAGGGAGTATTAATCATTATTTCTTCAGTAT
AAAGTTATTCTTCCTGAAAAAGTAAGATATACCTGGGAAATATTCTTGGATCCTTCACACATCCACTTAATTTCTTGAAGGAAGAAAACA
GACAAAAGACATGTAACAACAGAAACAAATAAACCACTTACTGTAAAATTTCAGAAATTGTGGGCTCATTCCCTCCCTCTAGTTTATTTA
TTTGCTCATCTTTATCACCTAATGGTAGTTTGTTTTCTTTGGTAGAGTATATGGCAGTCCCACATCGATGATAATTGGTGCTCCCTTCAT
CCAACTGGATCACTTTGAGATTCAGTTTTACATCATTTTAGCATTTTGTTTGTATATCAGTTGTGATGAGCCACTGATAAAATTTTGTTC
TAAAATGAAACATATTACTTTGTTAGTACATTTTTTAGTGTCACACTGACTTTTAAAATTTGAATGATATATAGACTTTGTTTTTTTAAT

>72258_72258_6_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000308008_DDX46_chr5_134130540_ENST00000452510_length(amino acids)=655AA_BP=165
MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVLVKGSMVL
PPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSVMRIVDNVRPDRQTV
MFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCM
SLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKA
LELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESMFNSKKRV
KDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLNYVPLEKQ
EEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQKAKAEIT

--------------------------------------------------------------
>72258_72258_7_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000507093_DDX46_chr5_134130540_ENST00000354283_length(transcript)=2737nt_BP=677nt
GTCGCGCGTGGGTAGAGGCCTTAGGCGGGCGTTGCGAAGGGTTGTTTGCTAGAGTTCGGACCTTGTTACGGCGCGAAGTTCCCTCCTTGG
GGCGGGGGAAAGGTACCGCACCCGCTACCTAGTGTGAATGAACTGTGGCGTGGGCTGCTAAGGGCAGGCTGCGGAGTACCCGGGCCGTGG
CCATGAACTCACCCGTGGACCCTGGCGCTAGGCAGGCGTTGAGGAAGAAGCCACCCGAGCGGACTCCCGAGGACTTAAATACTATTTATT
CTTATCTTCATGGAATGGAAATATTATCAAATCTCAGGGAACATCAGCTTAGATTAATGTCTGCAAGAGCACGCTATGAGAGATACAGTG
GCAATCAGGTTCTCTTTTGTTCAGAAACGATTGCCAGATGTTGGTATATCCTACTTTCTGGATCTGTGCTTGTGAAAGGCTCCATGGTCT
TGCCTCCTTGCAGTTTTGGTAAGCAGTTTGGAGGAAAAAGAGGATGTGATTGTCTTGTATTAGAGCCTTCAGAAATGATTGTGGTAGAGA
ATGCCAAAGATAATGAAGATAGTATTCTACAAAGAGAAATTCCTGCCAGACAATCCCGAAGAAGATTTCGGAAAATTAACTATAAAGGAG
AGCGCCAAACCATTACTGATGATGTGGAGGTTAACAGCTATCTTTCTGTCATGCGCATCGTGGATAATGTTCGTCCTGATCGACAGACGG
TTATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTATTGAAGTACAAGTTGGAGGCAGGA
GTGTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTTCTAGGCCATTATC
AAGAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATTTAATGAGAGCATCTTATCCTTGCA
TGTCTCTTCATGGAGGCATTGATCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGACCTGCAAACTTCTTGTGGCTACCT
CTGTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACCATTATGAGGATTATGTACACAGAG
CAGGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTCGCTATGCTGGTGACATAATTAAAG
CTCTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCTGAGGGGAAAATAA
TTAAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTAATGAGAGGAAGAAGTTACAAAAAG
CAGCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAAGCATGTTTAATTCAAAGAAGAGAG
TAAAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAATTAGAAATTGCTAAGAGATTGGCTC
TTAGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTCAGGATGTGATGCAGCAGGCCACCAATGCAATTCTTAGGGGTGGCACCATTC
TGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCAATTATGTGCCGTTAGAGAAACAAG
AAGAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCAATGACTTCCCACAGACTGCTAGGT
GGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCAGAGGAACCTACTTCCCTCCTGGCA
AAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAGGCAGAAATCACCA
GGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACAAAGTCTTATAGACATCCGGAAAAA
AGATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGTAAATGAAGATTTTTTAAATTCTAT
CTTGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCCACAATCAGTCAAACTATATTTAAA
GCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCGGATAATATTCTAGAGGTTTAAAAA
ATGGAAATATTTGAACTTTCTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTTTATCCTGTACTTTCAATGAAATTG
TGATCATTTCCTAAGAAAAGGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATGACTCTGGAACAATATGAACTGGAT
TTAAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCATAAATGGGCAAAAAGTAGTTGGAC

>72258_72258_7_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000507093_DDX46_chr5_134130540_ENST00000354283_length(amino acids)=662AA_BP=173
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSVMRIVDN
VRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDL
MRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQAR
YAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIES
MFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLN
YVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQ

--------------------------------------------------------------
>72258_72258_8_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000507093_DDX46_chr5_134130540_ENST00000452510_length(transcript)=4582nt_BP=677nt
GTCGCGCGTGGGTAGAGGCCTTAGGCGGGCGTTGCGAAGGGTTGTTTGCTAGAGTTCGGACCTTGTTACGGCGCGAAGTTCCCTCCTTGG
GGCGGGGGAAAGGTACCGCACCCGCTACCTAGTGTGAATGAACTGTGGCGTGGGCTGCTAAGGGCAGGCTGCGGAGTACCCGGGCCGTGG
CCATGAACTCACCCGTGGACCCTGGCGCTAGGCAGGCGTTGAGGAAGAAGCCACCCGAGCGGACTCCCGAGGACTTAAATACTATTTATT
CTTATCTTCATGGAATGGAAATATTATCAAATCTCAGGGAACATCAGCTTAGATTAATGTCTGCAAGAGCACGCTATGAGAGATACAGTG
GCAATCAGGTTCTCTTTTGTTCAGAAACGATTGCCAGATGTTGGTATATCCTACTTTCTGGATCTGTGCTTGTGAAAGGCTCCATGGTCT
TGCCTCCTTGCAGTTTTGGTAAGCAGTTTGGAGGAAAAAGAGGATGTGATTGTCTTGTATTAGAGCCTTCAGAAATGATTGTGGTAGAGA
ATGCCAAAGATAATGAAGATAGTATTCTACAAAGAGAAATTCCTGCCAGACAATCCCGAAGAAGATTTCGGAAAATTAACTATAAAGGAG
AGCGCCAAACCATTACTGATGATGTGGAGGTTAACAGCTATCTTTCTGTCATGCGCATCGTGGATAATGTTCGTCCTGATCGACAGACGG
TTATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTATTGAAGTACAAGTTGGAGGCAGGA
GTGTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTTCTAGGCCATTATC
AAGAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATTTAATGAGAGCATCTTATCCTTGCA
TGTCTCTTCATGGAGGCATTGATCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGACCTGCAAACTTCTTGTGGCTACCT
CTGTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACCATTATGAGGATTATGTACACAGAG
CAGGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTCGCTATGCTGGTGACATAATTAAAG
CTCTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCTGAGGGGAAAATAA
TTAAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTAATGAGAGGAAGAAGTTACAAAAAG
CAGCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAAGCATGTTTAATTCAAAGAAGAGAG
TAAAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAATTAGAAATTGCTAAGAGATTGGCTC
TTAGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTCAGGTAGATGTGATGCAGCAGGCCACCAATGCAATTCTTAGGGGTGGCACCA
TTCTGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCAATTATGTGCCGTTAGAGAAAC
AAGAAGAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCAATGACTTCCCACAGACTGCTA
GGTGGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCAGAGGAACCTACTTCCCTCCTG
GCAAAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAGGCAGAAATCA
CCAGGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACAAAGTCTTATAGACATCCGGAA
AAAAGATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGTAAATGAAGATTTTTTAAATTC
TATCTTGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCCACAATCAGTCAAACTATATTT
AAAGCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCGGATAATATTCTAGAGGTTTAA
AAAATGGAAATATTTGAACTTTCTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTTTATCCTGTACTTTCAATGAAA
TTGTGATCATTTCCTAAGAAAAGGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATGACTCTGGAACAATATGAACTG
GATTTAAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCATAAATGGGCAAAAAGTAGTTG
GACTAATTTCGGTTTTTATACAAGTAAAGATTTAATAGTATAAGGATTTTTTTGCATTTCTTTACACTGAGTGTAAAACTCTACAAAGAG
TTATAGTATTTACTACTTTGAGGTTTCCCTCACAACTTCTGGCTCCATACCTAGCCCCTCTTTTATAATCTTCCTTAAAAGAAAGAGTGT
AGCCTATAAATACTAAATATGATACCTTTTCCTTCTAGAAAGTGTTTATTTATATATCTATACATGTTGTATGTACAAATATCCTACTAC
TTTTAATCTGATTTTTCTTCAGGATTATTGAGTAGGTTGTGAATTTTCTTTCTTAAAAATTGTAAAACATAATGGTACCCAAGTTTTAAA
CTTAGATGTGCTTCATCTTAGTGAAATTTAATTCACAAGGAATCATAAATTGTGTTTTTGAGGCTGGGCGCAGTGACTCACACCTGTATC
CCAGCAATTTGGGAGGCCGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCTGTCTCTACT
AAAAATACAAAAATTAGTCGGCATGGTGGTGGGTGGCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCTGAGCCAAGATAAC
ACCATTGCACTCCAGCCTGGGCGACAGAGTGAGACTATCTCAAAAATAAATAAATAAATAAATAAATAGTATTTTTGAGCCTTCAAGATA
CAGTTCCTGAATATTCTAATTTAAATTGTTATAATTGGATTACCTAATATTCTTTTCAAGACTCCTGATGTATTAACTTCATGTTATTGT
CACTTTTCAAAAAAGGAATTTTTTTCAGGAGTTAAATAAAGTCAGTCTTTTATATCCAAGGGTTTCAAACCCACAGATTAAACCAACCAC
AGATCAAAAATAGAAAAAAAAAAAAAAAGAAAAAAAGAATGTAAAATTTTAAAAATACAGTTTAACAGCTGTAAAAGTTTTACTATAACA
TTTACATTGTGTTAGGTATTTTAAGTAATTTAAAGGTTACAGTATACAGGCGGTTAAAGTATACAGGAGGATGTGCATCGGTTATATGCA
TATAGCAAGCCATTTCATATAAGAGGCTTGAACATCCATGGATTTTGGTATAGAGGAGGGGTTTAAGGGGTGTCCTGCAATCAGTCCCCC
TCTCATACCAAAGGATGACTGTATATTTCTTAAATGAAGAGACTTTCATTCTTTAAATATTATTGACTTACAGTTTAAAAATAAATAAAT
AAAAGCATACTATAGTTGTAAAAACAAATAATTTTAATAGTATATTCAGTGGCTGAAGTGATAGGGAGTATTAATCATTATTTCTTCAGT
ATAAAGTTATTCTTCCTGAAAAAGTAAGATATACCTGGGAAATATTCTTGGATCCTTCACACATCCACTTAATTTCTTGAAGGAAGAAAA
CAGACAAAAGACATGTAACAACAGAAACAAATAAACCACTTACTGTAAAATTTCAGAAATTGTGGGCTCATTCCCTCCCTCTAGTTTATT
TATTTGCTCATCTTTATCACCTAATGGTAGTTTGTTTTCTTTGGTAGAGTATATGGCAGTCCCACATCGATGATAATTGGTGCTCCCTTC
ATCCAACTGGATCACTTTGAGATTCAGTTTTACATCATTTTAGCATTTTGTTTGTATATCAGTTGTGATGAGCCACTGATAAAATTTTGT
TCTAAAATGAAACATATTACTTTGTTAGTACATTTTTTAGTGTCACACTGACTTTTAAAATTTGAATGATATATAGACTTTGTTTTTTTA

>72258_72258_8_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000507093_DDX46_chr5_134130540_ENST00000452510_length(amino acids)=663AA_BP=173
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSVMRIVDN
VRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDL
MRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQAR
YAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIES
MFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKL
NYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAV

--------------------------------------------------------------
>72258_72258_9_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000509018_DDX46_chr5_134130540_ENST00000354283_length(transcript)=2761nt_BP=701nt
CCCGCGCAGACTTGTCTCCGGCCAGTCGCGCGTGGGTAGAGGCCTTAGGCGGGCGTTGCGAAGGGTTGTTTGCTAGAGTTCGGACCTTGT
TACGGCGCGAAGTTCCCTCCTTGGGGCGGGGGAAAGGTACCGCACCCGCTACCTAGTGTGAATGAACTGTGGCGTGGGCTGCTAAGGGCA
GGCTGCGGAGTACCCGGGCCGTGGCCATGAACTCACCCGTGGACCCTGGCGCTAGGCAGGCGTTGAGGAAGAAGCCACCCGAGCGGACTC
CCGAGGACTTAAATACTATTTATTCTTATCTTCATGGAATGGAAATATTATCAAATCTCAGGGAACATCAGCTTAGATTAATGTCTGCAA
GAGCACGCTATGAGAGATACAGTGGCAATCAGGTTCTCTTTTGTTCAGAAACGATTGCCAGATGTTGGTATATCCTACTTTCTGGATCTG
TGCTTGTGAAAGGCTCCATGGTCTTGCCTCCTTGCAGTTTTGGTAAGCAGTTTGGAGGAAAAAGAGGATGTGATTGTCTTGTATTAGAGC
CTTCAGAAATGATTGTGGTAGAGAATGCCAAAGATAATGAAGATAGTATTCTACAAAGAGAAATTCCTGCCAGACAATCCCGAAGAAGAT
TTCGGAAAATTAACTATAAAGGAGAGCGCCAAACCATTACTGATGATGTGGAGGTTAACAGCTATCTTTCTGTCATGCGCATCGTGGATA
ATGTTCGTCCTGATCGACAGACGGTTATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTA
TTGAAGTACAAGTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGT
TACTTGAGCTTCTAGGCCATTATCAAGAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATT
TAATGAGAGCATCTTATCCTTGCATGTCTCTTCATGGAGGCATTGATCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGA
CCTGCAAACTTCTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACC
ATTATGAGGATTATGTACACAGAGCAGGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTC
GCTATGCTGGTGACATAATTAAAGCTCTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATC
AGCAGAAAGCTGAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTA
ATGAGAGGAAGAAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAA
GCATGTTTAATTCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAAT
TAGAAATTGCTAAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTCAGGATGTGATGCAGCAGGCCACCAATG
CAATTCTTAGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCA
ATTATGTGCCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCA
ATGACTTCCCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCA
GAGGAACCTACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGC
AGAAAGCAAAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACA
AAGTCTTATAGACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGT
AAATGAAGATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCC
ACAATCAGTCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCG
GATAATATTCTAGAGGTTTAAAAAATGGAAATATTTGAACTTTCTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTT
TATCCTGTACTTTCAATGAAATTGTGATCATTTCCTAAGAAAAGGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATG
ACTCTGGAACAATATGAACTGGATTTAAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCA

>72258_72258_9_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000509018_DDX46_chr5_134130540_ENST00000354283_length(amino acids)=662AA_BP=173
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSVMRIVDN
VRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDL
MRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQAR
YAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIES
MFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLN
YVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQ

--------------------------------------------------------------
>72258_72258_10_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000509018_DDX46_chr5_134130540_ENST00000452510_length(transcript)=4606nt_BP=701nt
CCCGCGCAGACTTGTCTCCGGCCAGTCGCGCGTGGGTAGAGGCCTTAGGCGGGCGTTGCGAAGGGTTGTTTGCTAGAGTTCGGACCTTGT
TACGGCGCGAAGTTCCCTCCTTGGGGCGGGGGAAAGGTACCGCACCCGCTACCTAGTGTGAATGAACTGTGGCGTGGGCTGCTAAGGGCA
GGCTGCGGAGTACCCGGGCCGTGGCCATGAACTCACCCGTGGACCCTGGCGCTAGGCAGGCGTTGAGGAAGAAGCCACCCGAGCGGACTC
CCGAGGACTTAAATACTATTTATTCTTATCTTCATGGAATGGAAATATTATCAAATCTCAGGGAACATCAGCTTAGATTAATGTCTGCAA
GAGCACGCTATGAGAGATACAGTGGCAATCAGGTTCTCTTTTGTTCAGAAACGATTGCCAGATGTTGGTATATCCTACTTTCTGGATCTG
TGCTTGTGAAAGGCTCCATGGTCTTGCCTCCTTGCAGTTTTGGTAAGCAGTTTGGAGGAAAAAGAGGATGTGATTGTCTTGTATTAGAGC
CTTCAGAAATGATTGTGGTAGAGAATGCCAAAGATAATGAAGATAGTATTCTACAAAGAGAAATTCCTGCCAGACAATCCCGAAGAAGAT
TTCGGAAAATTAACTATAAAGGAGAGCGCCAAACCATTACTGATGATGTGGAGGTTAACAGCTATCTTTCTGTCATGCGCATCGTGGATA
ATGTTCGTCCTGATCGACAGACGGTTATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTA
TTGAAGTACAAGTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGT
TACTTGAGCTTCTAGGCCATTATCAAGAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATT
TAATGAGAGCATCTTATCCTTGCATGTCTCTTCATGGAGGCATTGATCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGA
CCTGCAAACTTCTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACC
ATTATGAGGATTATGTACACAGAGCAGGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTC
GCTATGCTGGTGACATAATTAAAGCTCTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATC
AGCAGAAAGCTGAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTA
ATGAGAGGAAGAAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAA
GCATGTTTAATTCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAAT
TAGAAATTGCTAAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTCAGGTAGATGTGATGCAGCAGGCCACCA
ATGCAATTCTTAGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGC
TCAATTATGTGCCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGA
TCAATGACTTCCCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAA
TCAGAGGAACCTACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTG
TGCAGAAAGCAAAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGAT
ACAAAGTCTTATAGACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTAT
TGTAAATGAAGATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACC
CCCACAATCAGTCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGT
CCGGATAATATTCTAGAGGTTTAAAAAATGGAAATATTTGAACTTTCTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCA
CTTTATCCTGTACTTTCAATGAAATTGTGATCATTTCCTAAGAAAAGGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTAC
ATGACTCTGGAACAATATGAACTGGATTTAAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCA
TCATAAATGGGCAAAAAGTAGTTGGACTAATTTCGGTTTTTATACAAGTAAAGATTTAATAGTATAAGGATTTTTTTGCATTTCTTTACA
CTGAGTGTAAAACTCTACAAAGAGTTATAGTATTTACTACTTTGAGGTTTCCCTCACAACTTCTGGCTCCATACCTAGCCCCTCTTTTAT
AATCTTCCTTAAAAGAAAGAGTGTAGCCTATAAATACTAAATATGATACCTTTTCCTTCTAGAAAGTGTTTATTTATATATCTATACATG
TTGTATGTACAAATATCCTACTACTTTTAATCTGATTTTTCTTCAGGATTATTGAGTAGGTTGTGAATTTTCTTTCTTAAAAATTGTAAA
ACATAATGGTACCCAAGTTTTAAACTTAGATGTGCTTCATCTTAGTGAAATTTAATTCACAAGGAATCATAAATTGTGTTTTTGAGGCTG
GGCGCAGTGACTCACACCTGTATCCCAGCAATTTGGGAGGCCGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCAAGACTAGCCTGGTCA
ACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGTCGGCATGGTGGTGGGTGGCTGTAATCCCAGCTACTCAGGAGGCTGAGG
CAGAAGAATCTGAGCCAAGATAACACCATTGCACTCCAGCCTGGGCGACAGAGTGAGACTATCTCAAAAATAAATAAATAAATAAATAAA
TAGTATTTTTGAGCCTTCAAGATACAGTTCCTGAATATTCTAATTTAAATTGTTATAATTGGATTACCTAATATTCTTTTCAAGACTCCT
GATGTATTAACTTCATGTTATTGTCACTTTTCAAAAAAGGAATTTTTTTCAGGAGTTAAATAAAGTCAGTCTTTTATATCCAAGGGTTTC
AAACCCACAGATTAAACCAACCACAGATCAAAAATAGAAAAAAAAAAAAAAAGAAAAAAAGAATGTAAAATTTTAAAAATACAGTTTAAC
AGCTGTAAAAGTTTTACTATAACATTTACATTGTGTTAGGTATTTTAAGTAATTTAAAGGTTACAGTATACAGGCGGTTAAAGTATACAG
GAGGATGTGCATCGGTTATATGCATATAGCAAGCCATTTCATATAAGAGGCTTGAACATCCATGGATTTTGGTATAGAGGAGGGGTTTAA
GGGGTGTCCTGCAATCAGTCCCCCTCTCATACCAAAGGATGACTGTATATTTCTTAAATGAAGAGACTTTCATTCTTTAAATATTATTGA
CTTACAGTTTAAAAATAAATAAATAAAAGCATACTATAGTTGTAAAAACAAATAATTTTAATAGTATATTCAGTGGCTGAAGTGATAGGG
AGTATTAATCATTATTTCTTCAGTATAAAGTTATTCTTCCTGAAAAAGTAAGATATACCTGGGAAATATTCTTGGATCCTTCACACATCC
ACTTAATTTCTTGAAGGAAGAAAACAGACAAAAGACATGTAACAACAGAAACAAATAAACCACTTACTGTAAAATTTCAGAAATTGTGGG
CTCATTCCCTCCCTCTAGTTTATTTATTTGCTCATCTTTATCACCTAATGGTAGTTTGTTTTCTTTGGTAGAGTATATGGCAGTCCCACA
TCGATGATAATTGGTGCTCCCTTCATCCAACTGGATCACTTTGAGATTCAGTTTTACATCATTTTAGCATTTTGTTTGTATATCAGTTGT
GATGAGCCACTGATAAAATTTTGTTCTAAAATGAAACATATTACTTTGTTAGTACATTTTTTAGTGTCACACTGACTTTTAAAATTTGAA
TGATATATAGACTTTGTTTTTTTAATGCAATATGAATATTTGCTCATGTTTTCTAAATTCCTTATAAAATAAAATTAATTCGAATTCAAT

>72258_72258_10_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000509018_DDX46_chr5_134130540_ENST00000452510_length(amino acids)=663AA_BP=173
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSVMRIVDN
VRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDL
MRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQAR
YAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIES
MFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKL
NYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAV

--------------------------------------------------------------
>72258_72258_11_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000510071_DDX46_chr5_134130540_ENST00000354283_length(transcript)=2756nt_BP=696nt
GCAGACTTGTCTCCGGCCAGTCGCGCGTGGGTAGAGGCCTTAGGCGGGCGTTGCGAAGGGTTGTTTGCTAGAGTTCGGACCTTGTTACGG
CGCGAAGTTCCCTCCTTGGGGCGGGGGAAAGGTACCGCACCCGCTACCTAGTGTGAATGAACTGTGGCGTGGGCTGCTAAGGGCAGGCTG
CGGAGTACCCGGGCCGTGGCCATGAACTCACCCGTGGACCCTGGCGCTAGGCAGGCGTTGAGGAAGAAGCCACCCGAGCGGACTCCCGAG
GACTTAAATACTATTTATTCTTATCTTCATGGAATGGAAATATTATCAAATCTCAGGGAACATCAGCTTAGATTAATGTCTGCAAGAGCA
CGCTATGAGAGATACAGTGGCAATCAGGTTCTCTTTTGTTCAGAAACGATTGCCAGATGTTGGTATATCCTACTTTCTGGATCTGTGCTT
GTGAAAGGCTCCATGGTCTTGCCTCCTTGCAGTTTTGGTAAGCAGTTTGGAGGAAAAAGAGGATGTGATTGTCTTGTATTAGAGCCTTCA
GAAATGATTGTGGTAGAGAATGCCAAAGATAATGAAGATAGTATTCTACAAAGAGAAATTCCTGCCAGACAATCCCGAAGAAGATTTCGG
AAAATTAACTATAAAGGAGAGCGCCAAACCATTACTGATGATGTGGAGGTTAACAGCTATCTTTCTGTCATGCGCATCGTGGATAATGTT
CGTCCTGATCGACAGACGGTTATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTATTGAA
GTACAAGTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGTTACTT
GAGCTTCTAGGCCATTATCAAGAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATTTAATG
AGAGCATCTTATCCTTGCATGTCTCTTCATGGAGGCATTGATCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGACCTGC
AAACTTCTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACCATTAT
GAGGATTATGTACACAGAGCAGGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTCGCTAT
GCTGGTGACATAATTAAAGCTCTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATCAGCAG
AAAGCTGAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTAATGAG
AGGAAGAAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAAGCATG
TTTAATTCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAATTAGAA
ATTGCTAAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTCAGGATGTGATGCAGCAGGCCACCAATGCAATT
CTTAGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCAATTAT
GTGCCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCAATGAC
TTCCCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCAGAGGA
ACCTACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGCAGAAA
GCAAAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACAAAGTC
TTATAGACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGTAAATG
AAGATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCCACAAT
CAGTCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCGGATAA
TATTCTAGAGGTTTAAAAAATGGAAATATTTGAACTTTCTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTTTATCC
TGTACTTTCAATGAAATTGTGATCATTTCCTAAGAAAAGGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATGACTCT
GGAACAATATGAACTGGATTTAAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCATAAAT

>72258_72258_11_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000510071_DDX46_chr5_134130540_ENST00000354283_length(amino acids)=662AA_BP=173
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSVMRIVDN
VRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDL
MRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQAR
YAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIES
MFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLN
YVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQ

--------------------------------------------------------------
>72258_72258_12_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000510071_DDX46_chr5_134130540_ENST00000452510_length(transcript)=4601nt_BP=696nt
GCAGACTTGTCTCCGGCCAGTCGCGCGTGGGTAGAGGCCTTAGGCGGGCGTTGCGAAGGGTTGTTTGCTAGAGTTCGGACCTTGTTACGG
CGCGAAGTTCCCTCCTTGGGGCGGGGGAAAGGTACCGCACCCGCTACCTAGTGTGAATGAACTGTGGCGTGGGCTGCTAAGGGCAGGCTG
CGGAGTACCCGGGCCGTGGCCATGAACTCACCCGTGGACCCTGGCGCTAGGCAGGCGTTGAGGAAGAAGCCACCCGAGCGGACTCCCGAG
GACTTAAATACTATTTATTCTTATCTTCATGGAATGGAAATATTATCAAATCTCAGGGAACATCAGCTTAGATTAATGTCTGCAAGAGCA
CGCTATGAGAGATACAGTGGCAATCAGGTTCTCTTTTGTTCAGAAACGATTGCCAGATGTTGGTATATCCTACTTTCTGGATCTGTGCTT
GTGAAAGGCTCCATGGTCTTGCCTCCTTGCAGTTTTGGTAAGCAGTTTGGAGGAAAAAGAGGATGTGATTGTCTTGTATTAGAGCCTTCA
GAAATGATTGTGGTAGAGAATGCCAAAGATAATGAAGATAGTATTCTACAAAGAGAAATTCCTGCCAGACAATCCCGAAGAAGATTTCGG
AAAATTAACTATAAAGGAGAGCGCCAAACCATTACTGATGATGTGGAGGTTAACAGCTATCTTTCTGTCATGCGCATCGTGGATAATGTT
CGTCCTGATCGACAGACGGTTATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTATTGAA
GTACAAGTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGTTACTT
GAGCTTCTAGGCCATTATCAAGAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATTTAATG
AGAGCATCTTATCCTTGCATGTCTCTTCATGGAGGCATTGATCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGACCTGC
AAACTTCTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACCATTAT
GAGGATTATGTACACAGAGCAGGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTCGCTAT
GCTGGTGACATAATTAAAGCTCTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATCAGCAG
AAAGCTGAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTAATGAG
AGGAAGAAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAAGCATG
TTTAATTCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAATTAGAA
ATTGCTAAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTCAGGTAGATGTGATGCAGCAGGCCACCAATGCA
ATTCTTAGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCAAT
TATGTGCCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCAAT
GACTTCCCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCAGA
GGAACCTACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGCAG
AAAGCAAAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACAAA
GTCTTATAGACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGTAA
ATGAAGATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCCAC
AATCAGTCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCGGA
TAATATTCTAGAGGTTTAAAAAATGGAAATATTTGAACTTTCTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTTTA
TCCTGTACTTTCAATGAAATTGTGATCATTTCCTAAGAAAAGGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATGAC
TCTGGAACAATATGAACTGGATTTAAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCATA
AATGGGCAAAAAGTAGTTGGACTAATTTCGGTTTTTATACAAGTAAAGATTTAATAGTATAAGGATTTTTTTGCATTTCTTTACACTGAG
TGTAAAACTCTACAAAGAGTTATAGTATTTACTACTTTGAGGTTTCCCTCACAACTTCTGGCTCCATACCTAGCCCCTCTTTTATAATCT
TCCTTAAAAGAAAGAGTGTAGCCTATAAATACTAAATATGATACCTTTTCCTTCTAGAAAGTGTTTATTTATATATCTATACATGTTGTA
TGTACAAATATCCTACTACTTTTAATCTGATTTTTCTTCAGGATTATTGAGTAGGTTGTGAATTTTCTTTCTTAAAAATTGTAAAACATA
ATGGTACCCAAGTTTTAAACTTAGATGTGCTTCATCTTAGTGAAATTTAATTCACAAGGAATCATAAATTGTGTTTTTGAGGCTGGGCGC
AGTGACTCACACCTGTATCCCAGCAATTTGGGAGGCCGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCAAGACTAGCCTGGTCAACATG
GTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGTCGGCATGGTGGTGGGTGGCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAA
GAATCTGAGCCAAGATAACACCATTGCACTCCAGCCTGGGCGACAGAGTGAGACTATCTCAAAAATAAATAAATAAATAAATAAATAGTA
TTTTTGAGCCTTCAAGATACAGTTCCTGAATATTCTAATTTAAATTGTTATAATTGGATTACCTAATATTCTTTTCAAGACTCCTGATGT
ATTAACTTCATGTTATTGTCACTTTTCAAAAAAGGAATTTTTTTCAGGAGTTAAATAAAGTCAGTCTTTTATATCCAAGGGTTTCAAACC
CACAGATTAAACCAACCACAGATCAAAAATAGAAAAAAAAAAAAAAAGAAAAAAAGAATGTAAAATTTTAAAAATACAGTTTAACAGCTG
TAAAAGTTTTACTATAACATTTACATTGTGTTAGGTATTTTAAGTAATTTAAAGGTTACAGTATACAGGCGGTTAAAGTATACAGGAGGA
TGTGCATCGGTTATATGCATATAGCAAGCCATTTCATATAAGAGGCTTGAACATCCATGGATTTTGGTATAGAGGAGGGGTTTAAGGGGT
GTCCTGCAATCAGTCCCCCTCTCATACCAAAGGATGACTGTATATTTCTTAAATGAAGAGACTTTCATTCTTTAAATATTATTGACTTAC
AGTTTAAAAATAAATAAATAAAAGCATACTATAGTTGTAAAAACAAATAATTTTAATAGTATATTCAGTGGCTGAAGTGATAGGGAGTAT
TAATCATTATTTCTTCAGTATAAAGTTATTCTTCCTGAAAAAGTAAGATATACCTGGGAAATATTCTTGGATCCTTCACACATCCACTTA
ATTTCTTGAAGGAAGAAAACAGACAAAAGACATGTAACAACAGAAACAAATAAACCACTTACTGTAAAATTTCAGAAATTGTGGGCTCAT
TCCCTCCCTCTAGTTTATTTATTTGCTCATCTTTATCACCTAATGGTAGTTTGTTTTCTTTGGTAGAGTATATGGCAGTCCCACATCGAT
GATAATTGGTGCTCCCTTCATCCAACTGGATCACTTTGAGATTCAGTTTTACATCATTTTAGCATTTTGTTTGTATATCAGTTGTGATGA
GCCACTGATAAAATTTTGTTCTAAAATGAAACATATTACTTTGTTAGTACATTTTTTAGTGTCACACTGACTTTTAAAATTTGAATGATA
TATAGACTTTGTTTTTTTAATGCAATATGAATATTTGCTCATGTTTTCTAAATTCCTTATAAAATAAAATTAATTCGAATTCAATCTGCA

>72258_72258_12_RAPGEF6-DDX46_RAPGEF6_chr5_130883740_ENST00000510071_DDX46_chr5_134130540_ENST00000452510_length(amino acids)=663AA_BP=173
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSVMRIVDN
VRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDL
MRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQAR
YAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIES
MFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKL
NYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAV

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Fusion Gene PPI Analysis for RAPGEF6-DDX46


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAPGEF6-DDX46


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAPGEF6-DDX46


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource