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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ASPSCR1-ANAPC11 (FusionGDB2 ID:7228)

Fusion Gene Summary for ASPSCR1-ANAPC11

Fusion gene summary

Fusion gene information	Fusion gene name: ASPSCR1-ANAPC11
	Fusion gene ID: 7228
		Hgene	Tgene
	Gene symbol	ASPSCR1	ANAPC11
	Gene ID	79058	51529
	Gene name	ASPSCR1 tether for SLC2A4, UBX domain containing	anaphase promoting complex subunit 11
	Synonyms	ASPCR1\|ASPL\|ASPS\|RCC17\|TUG\|UBXD9\|UBXN9	APC11\|Apc11p\|HSPC214
	Cytomap	17q25.3	17q25.3
	Type of gene	protein-coding	protein-coding
	Description	tether containing UBX domain for GLUT4ASPSCR1, UBX domain containing tether for SLC2A4UBX domain protein 9UBX domain-containing protein 9alveolar soft part sarcoma chromosomal region candidate gene 1 proteinalveolar soft part sarcoma chromosome regio	anaphase-promoting complex subunit 11APC11 anaphase promoting complex subunit 11 homologanaphase promoting complex subunit 11 (yeast APC11 homolog)cyclosome subunit 11hepatocellular carcinoma-associated RING finger protein
	Modification date	20200313	20200313
	UniProtAcc	Q9BZE9	Q9NYG5
	Ensembl transtripts involved in fusion gene	ENST00000306729, ENST00000306739, ENST00000581647, ENST00000580534, ENST00000582404,	ENST00000344877, ENST00000357385, ENST00000392376, ENST00000571024, ENST00000571570, ENST00000571874, ENST00000572639, ENST00000572851, ENST00000574924, ENST00000575195, ENST00000577425, ENST00000577747, ENST00000578544, ENST00000578550, ENST00000579133, ENST00000579978, ENST00000582222, ENST00000583839, ENST00000584314,
Fusion gene scores	* DoF score	9 X 6 X 8=432	5 X 6 X 4=120
	# samples	12	7
	** MAII score	log2(12/432*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ASPSCR1 [Title/Abstract] AND ANAPC11 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ASPSCR1(79935624)-ANAPC11(79852343), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ANAPC11	GO:0016567	protein ubiquitination	11739784
Tgene	ANAPC11	GO:0070979	protein K11-linked ubiquitination	18485873

Fusion gene breakpoints across ASPSCR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANAPC11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8296-01A	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+

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Fusion Gene ORF analysis for ASPSCR1-ANAPC11

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000306729	ENST00000344877	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000357385	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000392376	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000571024	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000571570	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000571874	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000572639	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000572851	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000574924	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000575195	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000577425	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000577747	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000578544	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000578550	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000579133	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000579978	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000582222	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000583839	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306729	ENST00000584314	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000344877	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000357385	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000392376	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000571024	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000571570	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000571874	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000572639	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000572851	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000574924	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000575195	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000577425	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000577747	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000578544	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000578550	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000579133	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000579978	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000582222	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000583839	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000306739	ENST00000584314	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000344877	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000357385	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000392376	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000571024	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000571570	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000571874	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000572639	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000572851	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000574924	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000575195	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000577425	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000577747	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000578544	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000578550	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000579133	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000579978	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000582222	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000583839	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5CDS-5UTR	ENST00000581647	ENST00000584314	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000344877	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000357385	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000392376	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000571024	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000571570	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000571874	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000572639	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000572851	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000574924	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000575195	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000577425	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000577747	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000578544	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000578550	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000579133	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000579978	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000582222	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000583839	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
5UTR-5UTR	ENST00000580534	ENST00000584314	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000344877	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000357385	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000392376	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000571024	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000571570	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000571874	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000572639	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000572851	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000574924	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000575195	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000577425	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000577747	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000578544	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000578550	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000579133	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000579978	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000582222	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000583839	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+
intron-5UTR	ENST00000582404	ENST00000584314	ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852343	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ASPSCR1-ANAPC11

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852342	+	1.20E-11	1
ASPSCR1	chr17	79935624	+	ANAPC11	chr17	79852342	+	1.20E-11	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ASPSCR1-ANAPC11

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:79935624/:79852343)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ASPSCR1 Q9BZE9	ANAPC11 Q9NYG5
FUNCTION: Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT. {ECO:0000250, ECO:0000269\|PubMed:23349634}.	FUNCTION: Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. {ECO:0000269\|PubMed:11739784, ECO:0000269\|PubMed:18485873}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ASPSCR1-ANAPC11

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ASPSCR1-ANAPC11

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ASPSCR1-ANAPC11

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ASPSCR1-ANAPC11

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source