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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RARA-CDK12 (FusionGDB2 ID:72286)

Fusion Gene Summary for RARA-CDK12

check button Fusion gene summary
Fusion gene informationFusion gene name: RARA-CDK12
Fusion gene ID: 72286
HgeneTgene
Gene symbol

RARA

CDK12

Gene ID

5914

51755

Gene nameretinoic acid receptor alphacyclin dependent kinase 12
SynonymsNR1B1|RARCRK7|CRKR|CRKRS
Cytomap

17q21.2

17q12

Type of geneprotein-codingprotein-coding
Descriptionretinoic acid receptor alphaRAR-alphanuclear receptor subfamily 1 group B member 1nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long formretinoic acid nuclear receptor alpha variant 1retinoic acid nuclear receptor alpha variant 2cyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12
Modification date2020032720200313
UniProtAcc.

Q9NYV4

Ensembl transtripts involved in fusion geneENST00000254066, ENST00000394081, 
ENST00000394086, ENST00000394089, 
ENST00000425707, ENST00000420042, 
ENST00000430627, ENST00000447079, 
ENST00000559545, 
Fusion gene scores* DoF score47 X 22 X 8=827236 X 30 X 14=15120
# samples 7455
** MAII scorelog2(74/8272*10)=-3.48263900979862
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(55/15120*10)=-4.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RARA [Title/Abstract] AND CDK12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRARA(38474700)-CDK12(37646810), # samples:3
RARA(38504716)-CDK12(37686857), # samples:3
RARA(38504716)-CDK12(37686856), # samples:3
Anticipated loss of major functional domain due to fusion event.RARA-CDK12 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RARA-CDK12 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
RARA-CDK12 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RARA-CDK12 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
RARA-CDK12 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
RARA-CDK12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
RARA-CDK12 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RARA-CDK12 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRARA

GO:0007165

signal transduction

2825025

HgeneRARA

GO:0030853

negative regulation of granulocyte differentiation

19917671

HgeneRARA

GO:0032689

negative regulation of interferon-gamma production

18416830

HgeneRARA

GO:0032720

negative regulation of tumor necrosis factor production

18416830

HgeneRARA

GO:0032736

positive regulation of interleukin-13 production

18416830

HgeneRARA

GO:0032753

positive regulation of interleukin-4 production

18416830

HgeneRARA

GO:0032754

positive regulation of interleukin-5 production

18416830

HgeneRARA

GO:0045630

positive regulation of T-helper 2 cell differentiation

18416830

HgeneRARA

GO:0045892

negative regulation of transcription, DNA-templated

20080953

HgeneRARA

GO:0045893

positive regulation of transcription, DNA-templated

18845237|19850744|20080953

HgeneRARA

GO:0045944

positive regulation of transcription by RNA polymerase II

19850744|21131358

HgeneRARA

GO:0071300

cellular response to retinoic acid

19917671

HgeneRARA

GO:0071391

cellular response to estrogen stimulus

20080953

TgeneCDK12

GO:0046777

protein autophosphorylation

11683387


check buttonFusion gene breakpoints across RARA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDK12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A04W-01ARARAchr17

38465538

+CDK12chr17

37646810

+
ChimerDB4BRCATCGA-A2-A04W-01ARARAchr17

38474700

-CDK12chr17

37646810

+
ChimerDB4BRCATCGA-A2-A04W-01ARARAchr17

38474700

+CDK12chr17

37646810

+
ChimerDB4BRCATCGA-A2-A04WRARAchr17

38465538

+CDK12chr17

37646809

+
ChimerDB4BRCATCGA-A2-A04WRARAchr17

38474700

+CDK12chr17

37646809

+
ChimerDB4BRCATCGA-AC-A2FB-01ARARAchr17

38474700

+CDK12chr17

37700502

+
ChimerDB4OVTCGA-3P-A9WA-01ARARAchr17

38504716

-CDK12chr17

37686857

+
ChimerDB4OVTCGA-3P-A9WA-01ARARAchr17

38504716

+CDK12chr17

37686857

+
ChimerDB4OVTCGA-3P-A9WA-01ARARAchr17

38504716

+CDK12chr17

37686884

+
ChimerDB4OVTCGA-3P-A9WA-01ARARAchr17

38504716

+CDK12chr17

37700502

+
ChimerDB4OVTCGA-3P-A9WARARAchr17

38504716

+CDK12chr17

37686856

+
ChimerDB4OVTCGA-3P-A9WARARAchr17

38504716

+CDK12chr17

37686883

+
ChimerDB4UCECTCGA-D1-A16ORARAchr17

38504716

+CDK12chr17

37686856

+


Top

Fusion Gene ORF analysis for RARA-CDK12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000254066ENST00000430627RARAchr17

38504716

+CDK12chr17

37686857

+
5CDS-intronENST00000254066ENST00000430627RARAchr17

38504716

+CDK12chr17

37700502

+
5CDS-intronENST00000254066ENST00000430627RARAchr17

38504716

+CDK12chr17

37686856

+
5CDS-intronENST00000254066ENST00000447079RARAchr17

38504716

+CDK12chr17

37686857

+
5CDS-intronENST00000254066ENST00000447079RARAchr17

38504716

+CDK12chr17

37700502

+
5CDS-intronENST00000254066ENST00000447079RARAchr17

38504716

+CDK12chr17

37686856

+
5CDS-intronENST00000254066ENST00000559545RARAchr17

38504716

+CDK12chr17

37686857

+
5CDS-intronENST00000254066ENST00000559545RARAchr17

38504716

+CDK12chr17

37686884

+
5CDS-intronENST00000254066ENST00000559545RARAchr17

38504716

+CDK12chr17

37700502

+
5CDS-intronENST00000254066ENST00000559545RARAchr17

38504716

+CDK12chr17

37686856

+
5CDS-intronENST00000254066ENST00000559545RARAchr17

38504716

+CDK12chr17

37686883

+
5CDS-intronENST00000394081ENST00000430627RARAchr17

38504716

+CDK12chr17

37686857

+
5CDS-intronENST00000394081ENST00000430627RARAchr17

38504716

+CDK12chr17

37700502

+
5CDS-intronENST00000394081ENST00000430627RARAchr17

38504716

+CDK12chr17

37686856

+
5CDS-intronENST00000394081ENST00000447079RARAchr17

38504716

+CDK12chr17

37686857

+
5CDS-intronENST00000394081ENST00000447079RARAchr17

38504716

+CDK12chr17

37700502

+
5CDS-intronENST00000394081ENST00000447079RARAchr17

38504716

+CDK12chr17

37686856

+
5CDS-intronENST00000394081ENST00000559545RARAchr17

38504716

+CDK12chr17

37686857

+
5CDS-intronENST00000394081ENST00000559545RARAchr17

38504716

+CDK12chr17

37686884

+
5CDS-intronENST00000394081ENST00000559545RARAchr17

38504716

+CDK12chr17

37700502

+
5CDS-intronENST00000394081ENST00000559545RARAchr17

38504716

+CDK12chr17

37686856

+
5CDS-intronENST00000394081ENST00000559545RARAchr17

38504716

+CDK12chr17

37686883

+
5CDS-intronENST00000394086ENST00000430627RARAchr17

38504716

+CDK12chr17

37686857

+
5CDS-intronENST00000394086ENST00000430627RARAchr17

38504716

+CDK12chr17

37700502

+
5CDS-intronENST00000394086ENST00000430627RARAchr17

38504716

+CDK12chr17

37686856

+
5CDS-intronENST00000394086ENST00000447079RARAchr17

38504716

+CDK12chr17

37686857

+
5CDS-intronENST00000394086ENST00000447079RARAchr17

38504716

+CDK12chr17

37700502

+
5CDS-intronENST00000394086ENST00000447079RARAchr17

38504716

+CDK12chr17

37686856

+
5CDS-intronENST00000394086ENST00000559545RARAchr17

38504716

+CDK12chr17

37686857

+
5CDS-intronENST00000394086ENST00000559545RARAchr17

38504716

+CDK12chr17

37686884

+
5CDS-intronENST00000394086ENST00000559545RARAchr17

38504716

+CDK12chr17

37700502

+
5CDS-intronENST00000394086ENST00000559545RARAchr17

38504716

+CDK12chr17

37686856

+
5CDS-intronENST00000394086ENST00000559545RARAchr17

38504716

+CDK12chr17

37686883

+
5CDS-intronENST00000394089ENST00000430627RARAchr17

38504716

+CDK12chr17

37686857

+
5CDS-intronENST00000394089ENST00000430627RARAchr17

38504716

+CDK12chr17

37700502

+
5CDS-intronENST00000394089ENST00000430627RARAchr17

38504716

+CDK12chr17

37686856

+
5CDS-intronENST00000394089ENST00000447079RARAchr17

38504716

+CDK12chr17

37686857

+
5CDS-intronENST00000394089ENST00000447079RARAchr17

38504716

+CDK12chr17

37700502

+
5CDS-intronENST00000394089ENST00000447079RARAchr17

38504716

+CDK12chr17

37686856

+
5CDS-intronENST00000394089ENST00000559545RARAchr17

38504716

+CDK12chr17

37686857

+
5CDS-intronENST00000394089ENST00000559545RARAchr17

38504716

+CDK12chr17

37686884

+
5CDS-intronENST00000394089ENST00000559545RARAchr17

38504716

+CDK12chr17

37700502

+
5CDS-intronENST00000394089ENST00000559545RARAchr17

38504716

+CDK12chr17

37686856

+
5CDS-intronENST00000394089ENST00000559545RARAchr17

38504716

+CDK12chr17

37686883

+
5UTR-3CDSENST00000254066ENST00000430627RARAchr17

38465538

+CDK12chr17

37646810

+
5UTR-3CDSENST00000254066ENST00000430627RARAchr17

38465538

+CDK12chr17

37646809

+
5UTR-3CDSENST00000254066ENST00000447079RARAchr17

38465538

+CDK12chr17

37646810

+
5UTR-3CDSENST00000254066ENST00000447079RARAchr17

38465538

+CDK12chr17

37646809

+
5UTR-3CDSENST00000394089ENST00000430627RARAchr17

38474700

+CDK12chr17

37646810

+
5UTR-3CDSENST00000394089ENST00000430627RARAchr17

38474700

+CDK12chr17

37646809

+
5UTR-3CDSENST00000394089ENST00000447079RARAchr17

38474700

+CDK12chr17

37646810

+
5UTR-3CDSENST00000394089ENST00000447079RARAchr17

38474700

+CDK12chr17

37646809

+
5UTR-3CDSENST00000425707ENST00000430627RARAchr17

38474700

+CDK12chr17

37646810

+
5UTR-3CDSENST00000425707ENST00000430627RARAchr17

38474700

+CDK12chr17

37646809

+
5UTR-3CDSENST00000425707ENST00000447079RARAchr17

38474700

+CDK12chr17

37646810

+
5UTR-3CDSENST00000425707ENST00000447079RARAchr17

38474700

+CDK12chr17

37646809

+
5UTR-intronENST00000254066ENST00000559545RARAchr17

38465538

+CDK12chr17

37646810

+
5UTR-intronENST00000254066ENST00000559545RARAchr17

38465538

+CDK12chr17

37646809

+
5UTR-intronENST00000394089ENST00000430627RARAchr17

38474700

+CDK12chr17

37700502

+
5UTR-intronENST00000394089ENST00000447079RARAchr17

38474700

+CDK12chr17

37700502

+
5UTR-intronENST00000394089ENST00000559545RARAchr17

38474700

+CDK12chr17

37646810

+
5UTR-intronENST00000394089ENST00000559545RARAchr17

38474700

+CDK12chr17

37646809

+
5UTR-intronENST00000394089ENST00000559545RARAchr17

38474700

+CDK12chr17

37700502

+
5UTR-intronENST00000425707ENST00000430627RARAchr17

38474700

+CDK12chr17

37700502

+
5UTR-intronENST00000425707ENST00000447079RARAchr17

38474700

+CDK12chr17

37700502

+
5UTR-intronENST00000425707ENST00000559545RARAchr17

38474700

+CDK12chr17

37646810

+
5UTR-intronENST00000425707ENST00000559545RARAchr17

38474700

+CDK12chr17

37646809

+
5UTR-intronENST00000425707ENST00000559545RARAchr17

38474700

+CDK12chr17

37700502

+
Frame-shiftENST00000254066ENST00000447079RARAchr17

38504716

+CDK12chr17

37686884

+
Frame-shiftENST00000254066ENST00000447079RARAchr17

38504716

+CDK12chr17

37686883

+
Frame-shiftENST00000394081ENST00000447079RARAchr17

38504716

+CDK12chr17

37686884

+
Frame-shiftENST00000394081ENST00000447079RARAchr17

38504716

+CDK12chr17

37686883

+
Frame-shiftENST00000394086ENST00000447079RARAchr17

38504716

+CDK12chr17

37686884

+
Frame-shiftENST00000394086ENST00000447079RARAchr17

38504716

+CDK12chr17

37686883

+
Frame-shiftENST00000394089ENST00000447079RARAchr17

38504716

+CDK12chr17

37686884

+
Frame-shiftENST00000394089ENST00000447079RARAchr17

38504716

+CDK12chr17

37686883

+
In-frameENST00000254066ENST00000430627RARAchr17

38504716

+CDK12chr17

37686884

+
In-frameENST00000254066ENST00000430627RARAchr17

38504716

+CDK12chr17

37686883

+
In-frameENST00000394081ENST00000430627RARAchr17

38504716

+CDK12chr17

37686884

+
In-frameENST00000394081ENST00000430627RARAchr17

38504716

+CDK12chr17

37686883

+
In-frameENST00000394086ENST00000430627RARAchr17

38504716

+CDK12chr17

37686884

+
In-frameENST00000394086ENST00000430627RARAchr17

38504716

+CDK12chr17

37686883

+
In-frameENST00000394089ENST00000430627RARAchr17

38504716

+CDK12chr17

37686884

+
In-frameENST00000394089ENST00000430627RARAchr17

38504716

+CDK12chr17

37686883

+
intron-3CDSENST00000254066ENST00000430627RARAchr17

38474700

+CDK12chr17

37646810

+
intron-3CDSENST00000254066ENST00000430627RARAchr17

38474700

+CDK12chr17

37646809

+
intron-3CDSENST00000254066ENST00000447079RARAchr17

38474700

+CDK12chr17

37646810

+
intron-3CDSENST00000254066ENST00000447079RARAchr17

38474700

+CDK12chr17

37646809

+
intron-3CDSENST00000394081ENST00000430627RARAchr17

38465538

+CDK12chr17

37646810

+
intron-3CDSENST00000394081ENST00000430627RARAchr17

38474700

+CDK12chr17

37646810

+
intron-3CDSENST00000394081ENST00000430627RARAchr17

38465538

+CDK12chr17

37646809

+
intron-3CDSENST00000394081ENST00000430627RARAchr17

38474700

+CDK12chr17

37646809

+
intron-3CDSENST00000394081ENST00000447079RARAchr17

38465538

+CDK12chr17

37646810

+
intron-3CDSENST00000394081ENST00000447079RARAchr17

38474700

+CDK12chr17

37646810

+
intron-3CDSENST00000394081ENST00000447079RARAchr17

38465538

+CDK12chr17

37646809

+
intron-3CDSENST00000394081ENST00000447079RARAchr17

38474700

+CDK12chr17

37646809

+
intron-3CDSENST00000394086ENST00000430627RARAchr17

38465538

+CDK12chr17

37646810

+
intron-3CDSENST00000394086ENST00000430627RARAchr17

38474700

+CDK12chr17

37646810

+
intron-3CDSENST00000394086ENST00000430627RARAchr17

38465538

+CDK12chr17

37646809

+
intron-3CDSENST00000394086ENST00000430627RARAchr17

38474700

+CDK12chr17

37646809

+
intron-3CDSENST00000394086ENST00000447079RARAchr17

38465538

+CDK12chr17

37646810

+
intron-3CDSENST00000394086ENST00000447079RARAchr17

38474700

+CDK12chr17

37646810

+
intron-3CDSENST00000394086ENST00000447079RARAchr17

38465538

+CDK12chr17

37646809

+
intron-3CDSENST00000394086ENST00000447079RARAchr17

38474700

+CDK12chr17

37646809

+
intron-3CDSENST00000394089ENST00000430627RARAchr17

38465538

+CDK12chr17

37646810

+
intron-3CDSENST00000394089ENST00000430627RARAchr17

38465538

+CDK12chr17

37646809

+
intron-3CDSENST00000394089ENST00000447079RARAchr17

38465538

+CDK12chr17

37646810

+
intron-3CDSENST00000394089ENST00000447079RARAchr17

38465538

+CDK12chr17

37646809

+
intron-3CDSENST00000420042ENST00000430627RARAchr17

38465538

+CDK12chr17

37646810

+
intron-3CDSENST00000420042ENST00000430627RARAchr17

38474700

+CDK12chr17

37646810

+
intron-3CDSENST00000420042ENST00000430627RARAchr17

38465538

+CDK12chr17

37646809

+
intron-3CDSENST00000420042ENST00000430627RARAchr17

38474700

+CDK12chr17

37646809

+
intron-3CDSENST00000420042ENST00000430627RARAchr17

38504716

+CDK12chr17

37686884

+
intron-3CDSENST00000420042ENST00000430627RARAchr17

38504716

+CDK12chr17

37686883

+
intron-3CDSENST00000420042ENST00000447079RARAchr17

38465538

+CDK12chr17

37646810

+
intron-3CDSENST00000420042ENST00000447079RARAchr17

38474700

+CDK12chr17

37646810

+
intron-3CDSENST00000420042ENST00000447079RARAchr17

38465538

+CDK12chr17

37646809

+
intron-3CDSENST00000420042ENST00000447079RARAchr17

38474700

+CDK12chr17

37646809

+
intron-3CDSENST00000420042ENST00000447079RARAchr17

38504716

+CDK12chr17

37686884

+
intron-3CDSENST00000420042ENST00000447079RARAchr17

38504716

+CDK12chr17

37686883

+
intron-3CDSENST00000425707ENST00000430627RARAchr17

38465538

+CDK12chr17

37646810

+
intron-3CDSENST00000425707ENST00000430627RARAchr17

38465538

+CDK12chr17

37646809

+
intron-3CDSENST00000425707ENST00000430627RARAchr17

38504716

+CDK12chr17

37686884

+
intron-3CDSENST00000425707ENST00000430627RARAchr17

38504716

+CDK12chr17

37686883

+
intron-3CDSENST00000425707ENST00000447079RARAchr17

38465538

+CDK12chr17

37646810

+
intron-3CDSENST00000425707ENST00000447079RARAchr17

38465538

+CDK12chr17

37646809

+
intron-3CDSENST00000425707ENST00000447079RARAchr17

38504716

+CDK12chr17

37686884

+
intron-3CDSENST00000425707ENST00000447079RARAchr17

38504716

+CDK12chr17

37686883

+
intron-intronENST00000254066ENST00000430627RARAchr17

38474700

+CDK12chr17

37700502

+
intron-intronENST00000254066ENST00000447079RARAchr17

38474700

+CDK12chr17

37700502

+
intron-intronENST00000254066ENST00000559545RARAchr17

38474700

+CDK12chr17

37646810

+
intron-intronENST00000254066ENST00000559545RARAchr17

38474700

+CDK12chr17

37646809

+
intron-intronENST00000254066ENST00000559545RARAchr17

38474700

+CDK12chr17

37700502

+
intron-intronENST00000394081ENST00000430627RARAchr17

38474700

+CDK12chr17

37700502

+
intron-intronENST00000394081ENST00000447079RARAchr17

38474700

+CDK12chr17

37700502

+
intron-intronENST00000394081ENST00000559545RARAchr17

38465538

+CDK12chr17

37646810

+
intron-intronENST00000394081ENST00000559545RARAchr17

38474700

+CDK12chr17

37646810

+
intron-intronENST00000394081ENST00000559545RARAchr17

38465538

+CDK12chr17

37646809

+
intron-intronENST00000394081ENST00000559545RARAchr17

38474700

+CDK12chr17

37646809

+
intron-intronENST00000394081ENST00000559545RARAchr17

38474700

+CDK12chr17

37700502

+
intron-intronENST00000394086ENST00000430627RARAchr17

38474700

+CDK12chr17

37700502

+
intron-intronENST00000394086ENST00000447079RARAchr17

38474700

+CDK12chr17

37700502

+
intron-intronENST00000394086ENST00000559545RARAchr17

38465538

+CDK12chr17

37646810

+
intron-intronENST00000394086ENST00000559545RARAchr17

38474700

+CDK12chr17

37646810

+
intron-intronENST00000394086ENST00000559545RARAchr17

38465538

+CDK12chr17

37646809

+
intron-intronENST00000394086ENST00000559545RARAchr17

38474700

+CDK12chr17

37646809

+
intron-intronENST00000394086ENST00000559545RARAchr17

38474700

+CDK12chr17

37700502

+
intron-intronENST00000394089ENST00000559545RARAchr17

38465538

+CDK12chr17

37646810

+
intron-intronENST00000394089ENST00000559545RARAchr17

38465538

+CDK12chr17

37646809

+
intron-intronENST00000420042ENST00000430627RARAchr17

38474700

+CDK12chr17

37700502

+
intron-intronENST00000420042ENST00000430627RARAchr17

38504716

+CDK12chr17

37686857

+
intron-intronENST00000420042ENST00000430627RARAchr17

38504716

+CDK12chr17

37700502

+
intron-intronENST00000420042ENST00000430627RARAchr17

38504716

+CDK12chr17

37686856

+
intron-intronENST00000420042ENST00000447079RARAchr17

38474700

+CDK12chr17

37700502

+
intron-intronENST00000420042ENST00000447079RARAchr17

38504716

+CDK12chr17

37686857

+
intron-intronENST00000420042ENST00000447079RARAchr17

38504716

+CDK12chr17

37700502

+
intron-intronENST00000420042ENST00000447079RARAchr17

38504716

+CDK12chr17

37686856

+
intron-intronENST00000420042ENST00000559545RARAchr17

38465538

+CDK12chr17

37646810

+
intron-intronENST00000420042ENST00000559545RARAchr17

38474700

+CDK12chr17

37646810

+
intron-intronENST00000420042ENST00000559545RARAchr17

38465538

+CDK12chr17

37646809

+
intron-intronENST00000420042ENST00000559545RARAchr17

38474700

+CDK12chr17

37646809

+
intron-intronENST00000420042ENST00000559545RARAchr17

38474700

+CDK12chr17

37700502

+
intron-intronENST00000420042ENST00000559545RARAchr17

38504716

+CDK12chr17

37686857

+
intron-intronENST00000420042ENST00000559545RARAchr17

38504716

+CDK12chr17

37686884

+
intron-intronENST00000420042ENST00000559545RARAchr17

38504716

+CDK12chr17

37700502

+
intron-intronENST00000420042ENST00000559545RARAchr17

38504716

+CDK12chr17

37686856

+
intron-intronENST00000420042ENST00000559545RARAchr17

38504716

+CDK12chr17

37686883

+
intron-intronENST00000425707ENST00000430627RARAchr17

38504716

+CDK12chr17

37686857

+
intron-intronENST00000425707ENST00000430627RARAchr17

38504716

+CDK12chr17

37700502

+
intron-intronENST00000425707ENST00000430627RARAchr17

38504716

+CDK12chr17

37686856

+
intron-intronENST00000425707ENST00000447079RARAchr17

38504716

+CDK12chr17

37686857

+
intron-intronENST00000425707ENST00000447079RARAchr17

38504716

+CDK12chr17

37700502

+
intron-intronENST00000425707ENST00000447079RARAchr17

38504716

+CDK12chr17

37686856

+
intron-intronENST00000425707ENST00000559545RARAchr17

38465538

+CDK12chr17

37646810

+
intron-intronENST00000425707ENST00000559545RARAchr17

38465538

+CDK12chr17

37646809

+
intron-intronENST00000425707ENST00000559545RARAchr17

38504716

+CDK12chr17

37686857

+
intron-intronENST00000425707ENST00000559545RARAchr17

38504716

+CDK12chr17

37686884

+
intron-intronENST00000425707ENST00000559545RARAchr17

38504716

+CDK12chr17

37700502

+
intron-intronENST00000425707ENST00000559545RARAchr17

38504716

+CDK12chr17

37686856

+
intron-intronENST00000425707ENST00000559545RARAchr17

38504716

+CDK12chr17

37686883

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000254066RARAchr1738504716+ENST00000430627CDK12chr1737686883+26297827751467230
ENST00000394089RARAchr1738504716+ENST00000430627CDK12chr1737686883+27048578501542230
ENST00000394086RARAchr1738504716+ENST00000430627CDK12chr1737686883+22243773701062230
ENST00000394081RARAchr1738504716+ENST00000430627CDK12chr1737686883+25016546471339230
ENST00000254066RARAchr1738504716+ENST00000430627CDK12chr1737686884+26297827751467230
ENST00000394089RARAchr1738504716+ENST00000430627CDK12chr1737686884+27048578501542230
ENST00000394086RARAchr1738504716+ENST00000430627CDK12chr1737686884+22243773701062230
ENST00000394081RARAchr1738504716+ENST00000430627CDK12chr1737686884+25016546471339230

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000254066ENST00000430627RARAchr1738504716+CDK12chr1737686883+0.208753480.79124653
ENST00000394089ENST00000430627RARAchr1738504716+CDK12chr1737686883+0.181783590.8182164
ENST00000394086ENST00000430627RARAchr1738504716+CDK12chr1737686883+0.205410080.7945899
ENST00000394081ENST00000430627RARAchr1738504716+CDK12chr1737686883+0.253477630.7465223
ENST00000254066ENST00000430627RARAchr1738504716+CDK12chr1737686884+0.208753480.79124653
ENST00000394089ENST00000430627RARAchr1738504716+CDK12chr1737686884+0.181783590.8182164
ENST00000394086ENST00000430627RARAchr1738504716+CDK12chr1737686884+0.205410080.7945899
ENST00000394081ENST00000430627RARAchr1738504716+CDK12chr1737686884+0.253477630.7465223

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Fusion Genomic Features for RARA-CDK12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RARAchr1738504716+CDK12chr1737686856+0.0001367010.99986327
RARAchr1738504716+CDK12chr1737686856+0.0001367010.99986327
RARAchr1738504716+CDK12chr1737686883+0.0001307850.9998692
RARAchr1738504716+CDK12chr1737686883+0.0001307850.9998692
RARAchr1738465538+CDK12chr1737646809+2.75E-050.99997246
RARAchr1738465538+CDK12chr1737646809+2.75E-050.99997246
RARAchr1738474700+CDK12chr1737646809+2.03E-060.999998
RARAchr1738474700+CDK12chr1737646809+2.03E-060.999998
RARAchr1738504716+CDK12chr1737686856+0.0001367010.99986327
RARAchr1738504716+CDK12chr1737686856+0.0001367010.99986327
RARAchr1738504716+CDK12chr1737686883+0.0001307850.9998692
RARAchr1738504716+CDK12chr1737686883+0.0001307850.9998692
RARAchr1738465538+CDK12chr1737646809+2.75E-050.99997246
RARAchr1738465538+CDK12chr1737646809+2.75E-050.99997246
RARAchr1738474700+CDK12chr1737646809+2.03E-060.999998
RARAchr1738474700+CDK12chr1737646809+2.03E-060.999998

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for RARA-CDK12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38474700/chr17:37646810)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDK12

Q9NYV4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRARAchr17:38504716chr17:37686883ENST00000254066+391_87109463.0RegionNote=Modulating
HgeneRARAchr17:38504716chr17:37686883ENST00000394081+281_87104458.0RegionNote=Modulating
HgeneRARAchr17:38504716chr17:37686883ENST00000394089+391_87109463.0RegionNote=Modulating
HgeneRARAchr17:38504716chr17:37686884ENST00000254066+391_87109463.0RegionNote=Modulating
HgeneRARAchr17:38504716chr17:37686884ENST00000394081+281_87104458.0RegionNote=Modulating
HgeneRARAchr17:38504716chr17:37686884ENST00000394089+391_87109463.0RegionNote=Modulating
HgeneRARAchr17:38504716chr17:37686883ENST00000254066+3988_108109463.0Zinc fingerNR C4-type
HgeneRARAchr17:38504716chr17:37686883ENST00000394089+3988_108109463.0Zinc fingerNR C4-type
HgeneRARAchr17:38504716chr17:37686884ENST00000254066+3988_108109463.0Zinc fingerNR C4-type
HgeneRARAchr17:38504716chr17:37686884ENST00000394089+3988_108109463.0Zinc fingerNR C4-type
TgeneCDK12chr17:38504716chr17:37686883ENST0000043062712141266_128012531482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38504716chr17:37686883ENST000004470790141266_128001491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38504716chr17:37686883ENST00000447079014407_41301491.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:38504716chr17:37686883ENST00000447079014535_54001491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38504716chr17:37686884ENST0000043062712141266_128012531482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38504716chr17:37686884ENST000004470790141266_128001491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38504716chr17:37686884ENST00000447079014407_41301491.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:38504716chr17:37686884ENST00000447079014535_54001491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38504716chr17:37686883ENST00000447079014727_102001491.0DomainProtein kinase
TgeneCDK12chr17:38504716chr17:37686884ENST00000447079014727_102001491.0DomainProtein kinase
TgeneCDK12chr17:38504716chr17:37686883ENST00000447079014733_74101491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:38504716chr17:37686883ENST00000447079014814_81901491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:38504716chr17:37686884ENST00000447079014733_74101491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:38504716chr17:37686884ENST00000447079014814_81901491.0Nucleotide bindingNote=ATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRARAchr17:38504716chr17:37686883ENST00000254066+3988_153109463.0DNA bindingNuclear receptor
HgeneRARAchr17:38504716chr17:37686883ENST00000394081+2888_153104458.0DNA bindingNuclear receptor
HgeneRARAchr17:38504716chr17:37686883ENST00000394089+3988_153109463.0DNA bindingNuclear receptor
HgeneRARAchr17:38504716chr17:37686883ENST00000425707+1788_1530366.0DNA bindingNuclear receptor
HgeneRARAchr17:38504716chr17:37686884ENST00000254066+3988_153109463.0DNA bindingNuclear receptor
HgeneRARAchr17:38504716chr17:37686884ENST00000394081+2888_153104458.0DNA bindingNuclear receptor
HgeneRARAchr17:38504716chr17:37686884ENST00000394089+3988_153109463.0DNA bindingNuclear receptor
HgeneRARAchr17:38504716chr17:37686884ENST00000425707+1788_1530366.0DNA bindingNuclear receptor
HgeneRARAchr17:38504716chr17:37686883ENST00000254066+39183_417109463.0DomainNR LBD
HgeneRARAchr17:38504716chr17:37686883ENST00000394081+28183_417104458.0DomainNR LBD
HgeneRARAchr17:38504716chr17:37686883ENST00000394089+39183_417109463.0DomainNR LBD
HgeneRARAchr17:38504716chr17:37686883ENST00000425707+17183_4170366.0DomainNR LBD
HgeneRARAchr17:38504716chr17:37686884ENST00000254066+39183_417109463.0DomainNR LBD
HgeneRARAchr17:38504716chr17:37686884ENST00000394081+28183_417104458.0DomainNR LBD
HgeneRARAchr17:38504716chr17:37686884ENST00000394089+39183_417109463.0DomainNR LBD
HgeneRARAchr17:38504716chr17:37686884ENST00000425707+17183_4170366.0DomainNR LBD
HgeneRARAchr17:38504716chr17:37686883ENST00000254066+39408_416109463.0Motif9aaTAD
HgeneRARAchr17:38504716chr17:37686883ENST00000394081+28408_416104458.0Motif9aaTAD
HgeneRARAchr17:38504716chr17:37686883ENST00000394089+39408_416109463.0Motif9aaTAD
HgeneRARAchr17:38504716chr17:37686883ENST00000425707+17408_4160366.0Motif9aaTAD
HgeneRARAchr17:38504716chr17:37686884ENST00000254066+39408_416109463.0Motif9aaTAD
HgeneRARAchr17:38504716chr17:37686884ENST00000394081+28408_416104458.0Motif9aaTAD
HgeneRARAchr17:38504716chr17:37686884ENST00000394089+39408_416109463.0Motif9aaTAD
HgeneRARAchr17:38504716chr17:37686884ENST00000425707+17408_4160366.0Motif9aaTAD
HgeneRARAchr17:38504716chr17:37686883ENST00000254066+39154_182109463.0RegionNote=Hinge
HgeneRARAchr17:38504716chr17:37686883ENST00000254066+39404_419109463.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38504716chr17:37686883ENST00000394081+28154_182104458.0RegionNote=Hinge
HgeneRARAchr17:38504716chr17:37686883ENST00000394081+28404_419104458.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38504716chr17:37686883ENST00000394089+39154_182109463.0RegionNote=Hinge
HgeneRARAchr17:38504716chr17:37686883ENST00000394089+39404_419109463.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38504716chr17:37686883ENST00000425707+17154_1820366.0RegionNote=Hinge
HgeneRARAchr17:38504716chr17:37686883ENST00000425707+171_870366.0RegionNote=Modulating
HgeneRARAchr17:38504716chr17:37686883ENST00000425707+17404_4190366.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38504716chr17:37686884ENST00000254066+39154_182109463.0RegionNote=Hinge
HgeneRARAchr17:38504716chr17:37686884ENST00000254066+39404_419109463.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38504716chr17:37686884ENST00000394081+28154_182104458.0RegionNote=Hinge
HgeneRARAchr17:38504716chr17:37686884ENST00000394081+28404_419104458.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38504716chr17:37686884ENST00000394089+39154_182109463.0RegionNote=Hinge
HgeneRARAchr17:38504716chr17:37686884ENST00000394089+39404_419109463.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38504716chr17:37686884ENST00000425707+17154_1820366.0RegionNote=Hinge
HgeneRARAchr17:38504716chr17:37686884ENST00000425707+171_870366.0RegionNote=Modulating
HgeneRARAchr17:38504716chr17:37686884ENST00000425707+17404_4190366.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38504716chr17:37686883ENST00000254066+39124_148109463.0Zinc fingerNR C4-type
HgeneRARAchr17:38504716chr17:37686883ENST00000394081+28124_148104458.0Zinc fingerNR C4-type
HgeneRARAchr17:38504716chr17:37686883ENST00000394081+2888_108104458.0Zinc fingerNR C4-type
HgeneRARAchr17:38504716chr17:37686883ENST00000394089+39124_148109463.0Zinc fingerNR C4-type
HgeneRARAchr17:38504716chr17:37686883ENST00000425707+17124_1480366.0Zinc fingerNR C4-type
HgeneRARAchr17:38504716chr17:37686883ENST00000425707+1788_1080366.0Zinc fingerNR C4-type
HgeneRARAchr17:38504716chr17:37686884ENST00000254066+39124_148109463.0Zinc fingerNR C4-type
HgeneRARAchr17:38504716chr17:37686884ENST00000394081+28124_148104458.0Zinc fingerNR C4-type
HgeneRARAchr17:38504716chr17:37686884ENST00000394081+2888_108104458.0Zinc fingerNR C4-type
HgeneRARAchr17:38504716chr17:37686884ENST00000394089+39124_148109463.0Zinc fingerNR C4-type
HgeneRARAchr17:38504716chr17:37686884ENST00000425707+17124_1480366.0Zinc fingerNR C4-type
HgeneRARAchr17:38504716chr17:37686884ENST00000425707+1788_1080366.0Zinc fingerNR C4-type
TgeneCDK12chr17:38504716chr17:37686883ENST000004306271214407_41312531482.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:38504716chr17:37686883ENST000004306271214535_54012531482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38504716chr17:37686884ENST000004306271214407_41312531482.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:38504716chr17:37686884ENST000004306271214535_54012531482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38504716chr17:37686883ENST000004306271214727_102012531482.0DomainProtein kinase
TgeneCDK12chr17:38504716chr17:37686884ENST000004306271214727_102012531482.0DomainProtein kinase
TgeneCDK12chr17:38504716chr17:37686883ENST000004306271214733_74112531482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:38504716chr17:37686883ENST000004306271214814_81912531482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:38504716chr17:37686884ENST000004306271214733_74112531482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:38504716chr17:37686884ENST000004306271214814_81912531482.0Nucleotide bindingNote=ATP


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Fusion Gene Sequence for RARA-CDK12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72286_72286_1_RARA-CDK12_RARA_chr17_38504716_ENST00000254066_CDK12_chr17_37686883_ENST00000430627_length(transcript)=2629nt_BP=782nt
CAGAAGCAGGGGGGAATCCTGAATCGAGCTGAGAGGGCTTCCCCGGTTCTCCTGGGAACCCCATCGGCCCCCTGCCAGCACACACCTGAG
CAGCATCACAGGACATGGCCCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGA
CCTTCCCAGGAAAAGTGCCAGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGG
GTGGGGGCTCCAGGAGACTGAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCT
GGGCCCAGGCCCCATGCCCCGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGC
TTGGCATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCC
CCCCTATGCTGGGTGGACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAG
CCACCATTGAGACCCAGAGCAGCAGTTCTGAAGAGATAGTGCCCAGCCCTCCCTCGCCACCCCCTCTACCCCGCATCTACAAGCCTTGCT
TTGTCTGTCAGGACAAGTCCTCAGGCTACCACTATGGGGTCAGCGCCTGTGAGGGCTGCAAGAGAAGAGGCCCCCTGAGCCCCCCGGACC
TCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCT
GCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACC
CCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTT
GACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCAC
AGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAA
GGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAG
CTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGG
GGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGA
ATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTAC
TAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAG
ATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAA
AGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTG
AATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGA
AACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGA
GCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACAT
AAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTC
TCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTT
GTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATT
GTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGAC
ATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAATAACAGCATTTAGCATATTGTTTACACATATATTTTTAT

>72286_72286_1_RARA-CDK12_RARA_chr17_38504716_ENST00000254066_CDK12_chr17_37686883_ENST00000430627_length(amino acids)=230AA_BP=2
MQEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSA
IDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY

--------------------------------------------------------------
>72286_72286_2_RARA-CDK12_RARA_chr17_38504716_ENST00000254066_CDK12_chr17_37686884_ENST00000430627_length(transcript)=2629nt_BP=782nt
CAGAAGCAGGGGGGAATCCTGAATCGAGCTGAGAGGGCTTCCCCGGTTCTCCTGGGAACCCCATCGGCCCCCTGCCAGCACACACCTGAG
CAGCATCACAGGACATGGCCCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGA
CCTTCCCAGGAAAAGTGCCAGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGG
GTGGGGGCTCCAGGAGACTGAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCT
GGGCCCAGGCCCCATGCCCCGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGC
TTGGCATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCC
CCCCTATGCTGGGTGGACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAG
CCACCATTGAGACCCAGAGCAGCAGTTCTGAAGAGATAGTGCCCAGCCCTCCCTCGCCACCCCCTCTACCCCGCATCTACAAGCCTTGCT
TTGTCTGTCAGGACAAGTCCTCAGGCTACCACTATGGGGTCAGCGCCTGTGAGGGCTGCAAGAGAAGAGGCCCCCTGAGCCCCCCGGACC
TCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCT
GCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACC
CCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTT
GACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCAC
AGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAA
GGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAG
CTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGG
GGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGA
ATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTAC
TAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAG
ATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAA
AGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTG
AATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGA
AACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGA
GCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACAT
AAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTC
TCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTT
GTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATT
GTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGAC
ATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAATAACAGCATTTAGCATATTGTTTACACATATATTTTTAT

>72286_72286_2_RARA-CDK12_RARA_chr17_38504716_ENST00000254066_CDK12_chr17_37686884_ENST00000430627_length(amino acids)=230AA_BP=2
MQEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSA
IDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY

--------------------------------------------------------------
>72286_72286_3_RARA-CDK12_RARA_chr17_38504716_ENST00000394081_CDK12_chr17_37686883_ENST00000430627_length(transcript)=2501nt_BP=654nt
AGCCGCTGTACTCTGCCTCGGACGCCACGAGACTCTAGACGGGAGTCCCCTCGAGGTGAAGCCGCTGAGTTCCCGGGCCCCGCCAGGCTT
CCCTGGGAGAGCCGACGGACCCCCCCTCCCAGCACACACAACTTCCCTGCTTTTCACCGGGACTGGCGGAGCGGCCGGCGGACTTAGACG
CGGGGACTTCAGGGCAGGGGGCGCCCCCTGCCCGGGTCACCAGTCGGGGCGAGGGGACGTCTCCTCTCCCCCAGCTGCTCTGCTCGGATG
GCGCCGCCGGCTGAGTGACGGGGGCGGCGCGCAGGACTTCCCAGCTCGGACCTCTTGCCTTCGAGGGGAAAGATGTACGAGAGTGTAGAA
GTGGGGGGTCCCACCCCTAATCCCTTCCTAGTGGTGGATTTTTATAACCAGAACCGGGCCTGTTTGCTCCCAGAGAAGGGGCTCCCCGCC
CCGGGTCCGTACTCCACCCCGCTCCGGACTCCGCTTTGGAATGGCTCAAACCACTCCATTGAGACCCAGAGCAGCAGTTCTGAAGAGATA
GTGCCCAGCCCTCCCTCGCCACCCCCTCTACCCCGCATCTACAAGCCTTGCTTTGTCTGTCAGGACAAGTCCTCAGGCTACCACTATGGG
GTCAGCGCCTGTGAGGGCTGCAAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCG
ATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCC
ACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTG
AAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGA
CCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTT
TTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGA
CCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGT
CTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACT
TCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCAT
CTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGT
TCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAA
AAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTC
TTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAA
GAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTT
CCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCA
TCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAG
GTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC
TCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGA
TAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTT
TTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATT

>72286_72286_3_RARA-CDK12_RARA_chr17_38504716_ENST00000394081_CDK12_chr17_37686883_ENST00000430627_length(amino acids)=230AA_BP=2
MQEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSA
IDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY

--------------------------------------------------------------
>72286_72286_4_RARA-CDK12_RARA_chr17_38504716_ENST00000394081_CDK12_chr17_37686884_ENST00000430627_length(transcript)=2501nt_BP=654nt
AGCCGCTGTACTCTGCCTCGGACGCCACGAGACTCTAGACGGGAGTCCCCTCGAGGTGAAGCCGCTGAGTTCCCGGGCCCCGCCAGGCTT
CCCTGGGAGAGCCGACGGACCCCCCCTCCCAGCACACACAACTTCCCTGCTTTTCACCGGGACTGGCGGAGCGGCCGGCGGACTTAGACG
CGGGGACTTCAGGGCAGGGGGCGCCCCCTGCCCGGGTCACCAGTCGGGGCGAGGGGACGTCTCCTCTCCCCCAGCTGCTCTGCTCGGATG
GCGCCGCCGGCTGAGTGACGGGGGCGGCGCGCAGGACTTCCCAGCTCGGACCTCTTGCCTTCGAGGGGAAAGATGTACGAGAGTGTAGAA
GTGGGGGGTCCCACCCCTAATCCCTTCCTAGTGGTGGATTTTTATAACCAGAACCGGGCCTGTTTGCTCCCAGAGAAGGGGCTCCCCGCC
CCGGGTCCGTACTCCACCCCGCTCCGGACTCCGCTTTGGAATGGCTCAAACCACTCCATTGAGACCCAGAGCAGCAGTTCTGAAGAGATA
GTGCCCAGCCCTCCCTCGCCACCCCCTCTACCCCGCATCTACAAGCCTTGCTTTGTCTGTCAGGACAAGTCCTCAGGCTACCACTATGGG
GTCAGCGCCTGTGAGGGCTGCAAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCG
ATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCC
ACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTG
AAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGA
CCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTT
TTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGA
CCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGT
CTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACT
TCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCAT
CTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGT
TCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAA
AAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTC
TTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAA
GAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTT
CCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCA
TCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAG
GTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC
TCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGA
TAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTT
TTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATT

>72286_72286_4_RARA-CDK12_RARA_chr17_38504716_ENST00000394081_CDK12_chr17_37686884_ENST00000430627_length(amino acids)=230AA_BP=2
MQEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSA
IDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY

--------------------------------------------------------------
>72286_72286_5_RARA-CDK12_RARA_chr17_38504716_ENST00000394086_CDK12_chr17_37686883_ENST00000430627_length(transcript)=2224nt_BP=377nt
ACATGATGTCACAGACAATGACACAAGCCGGTGTCTCATTCCGACACAGCGTCCGAGCTGCACAATGTCACACCCGGGTGCCAAACACTT
GGCCCCGCGCGACCCGGCCCTACGCCTCCTGCCGCCGCTCTCCGCGTCTCCGGGGGAGGTGGCCCGGTTCGGCCGGGCAGGGGGCTGGCG
GGCGAGCCCCGCGGGCGGGCTGGCGAGCGGGTGATGTCACGGGCAGCGCCATTGAGACCCAGAGCAGCAGTTCTGAAGAGATAGTGCCCA
GCCCTCCCTCGCCACCCCCTCTACCCCGCATCTACAAGCCTTGCTTTGTCTGTCAGGACAAGTCCTCAGGCTACCACTATGGGGTCAGCG
CCTGTGAGGGCTGCAAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTC
CAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCC
ACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGG
GTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTC
AGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAG
GGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATT
GCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGC
TTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACTTCAGTGT
CCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATT
TGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCT
GGATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAA
TGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATT
TTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATA
GTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCC
ACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAA
AGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACT
TTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT
GTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCT
TTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACC
ATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAG

>72286_72286_5_RARA-CDK12_RARA_chr17_38504716_ENST00000394086_CDK12_chr17_37686883_ENST00000430627_length(amino acids)=230AA_BP=2
MQEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSA
IDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY

--------------------------------------------------------------
>72286_72286_6_RARA-CDK12_RARA_chr17_38504716_ENST00000394086_CDK12_chr17_37686884_ENST00000430627_length(transcript)=2224nt_BP=377nt
ACATGATGTCACAGACAATGACACAAGCCGGTGTCTCATTCCGACACAGCGTCCGAGCTGCACAATGTCACACCCGGGTGCCAAACACTT
GGCCCCGCGCGACCCGGCCCTACGCCTCCTGCCGCCGCTCTCCGCGTCTCCGGGGGAGGTGGCCCGGTTCGGCCGGGCAGGGGGCTGGCG
GGCGAGCCCCGCGGGCGGGCTGGCGAGCGGGTGATGTCACGGGCAGCGCCATTGAGACCCAGAGCAGCAGTTCTGAAGAGATAGTGCCCA
GCCCTCCCTCGCCACCCCCTCTACCCCGCATCTACAAGCCTTGCTTTGTCTGTCAGGACAAGTCCTCAGGCTACCACTATGGGGTCAGCG
CCTGTGAGGGCTGCAAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTC
CAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCC
ACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGG
GTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTC
AGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAG
GGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATT
GCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGC
TTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACTTCAGTGT
CCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATT
TGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCT
GGATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAA
TGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATT
TTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATA
GTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCC
ACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAA
AGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACT
TTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT
GTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCT
TTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACC
ATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAG

>72286_72286_6_RARA-CDK12_RARA_chr17_38504716_ENST00000394086_CDK12_chr17_37686884_ENST00000430627_length(amino acids)=230AA_BP=2
MQEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSA
IDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY

--------------------------------------------------------------
>72286_72286_7_RARA-CDK12_RARA_chr17_38504716_ENST00000394089_CDK12_chr17_37686883_ENST00000430627_length(transcript)=2704nt_BP=857nt
GTGACTCGCTATGGCCGCTGCCATCGCCCCGCGCCCCTGAGCCGCGGCCCCCTGGACGGCTCCTCTCCCGGGACCCCGCACCCTGATGCC
GAGCAGCACCAGGGCGCCGGGTTAGGGCAGACGCTGTGCTCGCTGGCACCCCGAACGGGTTGCTTCCCCCGCTGCGAGCATCACAGGACA
TGGCCCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGACCTTCCCAGGAAAAG
TGCCAGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGGGTGGGGGCTCCAGGA
GACTGAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCTGGGCCCAGGCCCCAT
GCCCCGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGCTTGGCATGGCCAGCA
ACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTG
GACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCACCATTGAGACCC
AGAGCAGCAGTTCTGAAGAGATAGTGCCCAGCCCTCCCTCGCCACCCCCTCTACCCCGCATCTACAAGCCTTGCTTTGTCTGTCAGGACA
AGTCCTCAGGCTACCACTATGGGGTCAGCGCCTGTGAGGGCTGCAAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACC
TCCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCA
GCCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGAC
TTATGGAAACACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGT
CCAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTT
TCCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAG
CAATTCTGTGGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCT
TCACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGG
AGTTCCTTACTAACCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATC
ATTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTAC
GAAATAATGATGTTGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAAT
ATGGAGAGGATCATTACATTGAAAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTA
TTGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGT
GTTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGG
CTGATTTGAATAAATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATAC
TTTTTTTCCAAATAAATTACTCATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGA
ACGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCT
CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCG
TTGAGATGCCCAAGAACCTGGGATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCT
TCAATTCTAAAATGTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTG
TGGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAATAACAGCATTTAGCATATTGTTTACACATATATTTTTATGTCAAAAAAAAAACA

>72286_72286_7_RARA-CDK12_RARA_chr17_38504716_ENST00000394089_CDK12_chr17_37686883_ENST00000430627_length(amino acids)=230AA_BP=2
MQEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSA
IDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY

--------------------------------------------------------------
>72286_72286_8_RARA-CDK12_RARA_chr17_38504716_ENST00000394089_CDK12_chr17_37686884_ENST00000430627_length(transcript)=2704nt_BP=857nt
GTGACTCGCTATGGCCGCTGCCATCGCCCCGCGCCCCTGAGCCGCGGCCCCCTGGACGGCTCCTCTCCCGGGACCCCGCACCCTGATGCC
GAGCAGCACCAGGGCGCCGGGTTAGGGCAGACGCTGTGCTCGCTGGCACCCCGAACGGGTTGCTTCCCCCGCTGCGAGCATCACAGGACA
TGGCCCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGACCTTCCCAGGAAAAG
TGCCAGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGGGTGGGGGCTCCAGGA
GACTGAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCTGGGCCCAGGCCCCAT
GCCCCGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGCTTGGCATGGCCAGCA
ACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTG
GACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCACCATTGAGACCC
AGAGCAGCAGTTCTGAAGAGATAGTGCCCAGCCCTCCCTCGCCACCCCCTCTACCCCGCATCTACAAGCCTTGCTTTGTCTGTCAGGACA
AGTCCTCAGGCTACCACTATGGGGTCAGCGCCTGTGAGGGCTGCAAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACC
TCCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCA
GCCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGAC
TTATGGAAACACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGT
CCAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTT
TCCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAG
CAATTCTGTGGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCT
TCACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGG
AGTTCCTTACTAACCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATC
ATTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTAC
GAAATAATGATGTTGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAAT
ATGGAGAGGATCATTACATTGAAAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTA
TTGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGT
GTTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGG
CTGATTTGAATAAATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATAC
TTTTTTTCCAAATAAATTACTCATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGA
ACGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCT
CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCG
TTGAGATGCCCAAGAACCTGGGATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCT
TCAATTCTAAAATGTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTG
TGGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAATAACAGCATTTAGCATATTGTTTACACATATATTTTTATGTCAAAAAAAAAACA

>72286_72286_8_RARA-CDK12_RARA_chr17_38504716_ENST00000394089_CDK12_chr17_37686884_ENST00000430627_length(amino acids)=230AA_BP=2
MQEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSA
IDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RARA-CDK12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RARA-CDK12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RARA-CDK12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource