FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:RARA-SKAP1 (FusionGDB2 ID:72315)

Fusion Gene Summary for RARA-SKAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: RARA-SKAP1
Fusion gene ID: 72315
HgeneTgene
Gene symbol

RARA

SKAP1

Gene ID

5914

8631

Gene nameretinoic acid receptor alphasrc kinase associated phosphoprotein 1
SynonymsNR1B1|RARHEL-S-81p|SCAP1|SKAP55
Cytomap

17q21.2

17q21.32

Type of geneprotein-codingprotein-coding
Descriptionretinoic acid receptor alphaRAR-alphanuclear receptor subfamily 1 group B member 1nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long formretinoic acid nuclear receptor alpha variant 1retinoic acid nuclear receptor alpha variant 2src kinase-associated phosphoprotein 1SKAP-55epididymis secretory sperm binding protein Li 81ppp55src family-associated phosphoprotein 1src kinase-associated phosphoprotein of 55 kDa
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000254066, ENST00000394089, 
ENST00000425707, ENST00000394081, 
ENST00000394086, ENST00000420042, 
ENST00000336915, ENST00000584924, 
Fusion gene scores* DoF score47 X 22 X 8=827224 X 12 X 10=2880
# samples 7429
** MAII scorelog2(74/8272*10)=-3.48263900979862
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/2880*10)=-3.31194400631474
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RARA [Title/Abstract] AND SKAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRARA(38487648)-SKAP1(46214699), # samples:4
Anticipated loss of major functional domain due to fusion event.RARA-SKAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RARA-SKAP1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
RARA-SKAP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RARA-SKAP1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
RARA-SKAP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRARA

GO:0007165

signal transduction

2825025

HgeneRARA

GO:0030853

negative regulation of granulocyte differentiation

19917671

HgeneRARA

GO:0032689

negative regulation of interferon-gamma production

18416830

HgeneRARA

GO:0032720

negative regulation of tumor necrosis factor production

18416830

HgeneRARA

GO:0032736

positive regulation of interleukin-13 production

18416830

HgeneRARA

GO:0032753

positive regulation of interleukin-4 production

18416830

HgeneRARA

GO:0032754

positive regulation of interleukin-5 production

18416830

HgeneRARA

GO:0045630

positive regulation of T-helper 2 cell differentiation

18416830

HgeneRARA

GO:0045892

negative regulation of transcription, DNA-templated

20080953

HgeneRARA

GO:0045893

positive regulation of transcription, DNA-templated

18845237|19850744|20080953

HgeneRARA

GO:0045944

positive regulation of transcription by RNA polymerase II

19850744|21131358

HgeneRARA

GO:0071300

cellular response to retinoic acid

19917671

HgeneRARA

GO:0071391

cellular response to estrogen stimulus

20080953

TgeneSKAP1

GO:0002821

positive regulation of adaptive immune response

12652296

TgeneSKAP1

GO:0033625

positive regulation of integrin activation

12652296

TgeneSKAP1

GO:0034116

positive regulation of heterotypic cell-cell adhesion

12652296

TgeneSKAP1

GO:0045944

positive regulation of transcription by RNA polymerase II

11909961

TgeneSKAP1

GO:1903039

positive regulation of leukocyte cell-cell adhesion

12652296


check buttonFusion gene breakpoints across RARA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SKAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0IN-01ARARAchr17

38487647

+SKAP1chr17

46211177

-
ChimerDB4BRCATCGA-B6-A0IN-01ARARAchr17

38487647

+SKAP1chr17

46214698

-
ChimerDB4BRCATCGA-B6-A0IN-01ARARAchr17

38487648

+SKAP1chr17

46211178

-
ChimerDB4BRCATCGA-B6-A0IN-01ARARAchr17

38487648

-SKAP1chr17

46214699

-
ChimerDB4BRCATCGA-B6-A0IN-01ARARAchr17

38487648

+SKAP1chr17

46214699

-
ChimerDB4BRCATCGA-B6-A0IN-01ARARAchr17

38499119

+SKAP1chr17

46214699

-
ChimerDB4BRCATCGA-B6-A0INRARAchr17

38487648

+SKAP1chr17

46211178

-
ChimerDB4BRCATCGA-B6-A0INRARAchr17

38487648

+SKAP1chr17

46214699

-
ChimerDB4BRCATCGA-B6-A0INRARAchr17

38499119

+SKAP1chr17

46214699

-


Top

Fusion Gene ORF analysis for RARA-SKAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000254066ENST00000336915RARAchr17

38487647

+SKAP1chr17

46211177

-
5CDS-3UTRENST00000254066ENST00000336915RARAchr17

38487648

+SKAP1chr17

46211178

-
5CDS-3UTRENST00000394089ENST00000336915RARAchr17

38487647

+SKAP1chr17

46211177

-
5CDS-3UTRENST00000394089ENST00000336915RARAchr17

38487648

+SKAP1chr17

46211178

-
5CDS-3UTRENST00000425707ENST00000336915RARAchr17

38487647

+SKAP1chr17

46211177

-
5CDS-3UTRENST00000425707ENST00000336915RARAchr17

38487648

+SKAP1chr17

46211178

-
5CDS-intronENST00000254066ENST00000584924RARAchr17

38487647

+SKAP1chr17

46211177

-
5CDS-intronENST00000254066ENST00000584924RARAchr17

38487648

+SKAP1chr17

46211178

-
5CDS-intronENST00000394089ENST00000584924RARAchr17

38487647

+SKAP1chr17

46211177

-
5CDS-intronENST00000394089ENST00000584924RARAchr17

38487648

+SKAP1chr17

46211178

-
5CDS-intronENST00000425707ENST00000584924RARAchr17

38487647

+SKAP1chr17

46211177

-
5CDS-intronENST00000425707ENST00000584924RARAchr17

38487648

+SKAP1chr17

46211178

-
Frame-shiftENST00000254066ENST00000584924RARAchr17

38487647

+SKAP1chr17

46214698

-
Frame-shiftENST00000254066ENST00000584924RARAchr17

38487648

+SKAP1chr17

46214699

-
Frame-shiftENST00000394081ENST00000584924RARAchr17

38499119

+SKAP1chr17

46214699

-
Frame-shiftENST00000394089ENST00000584924RARAchr17

38487647

+SKAP1chr17

46214698

-
Frame-shiftENST00000394089ENST00000584924RARAchr17

38487648

+SKAP1chr17

46214699

-
Frame-shiftENST00000425707ENST00000584924RARAchr17

38487647

+SKAP1chr17

46214698

-
Frame-shiftENST00000425707ENST00000584924RARAchr17

38487648

+SKAP1chr17

46214699

-
In-frameENST00000254066ENST00000336915RARAchr17

38487647

+SKAP1chr17

46214698

-
In-frameENST00000254066ENST00000336915RARAchr17

38487648

+SKAP1chr17

46214699

-
In-frameENST00000394081ENST00000336915RARAchr17

38499119

+SKAP1chr17

46214699

-
In-frameENST00000394089ENST00000336915RARAchr17

38487647

+SKAP1chr17

46214698

-
In-frameENST00000394089ENST00000336915RARAchr17

38487648

+SKAP1chr17

46214699

-
In-frameENST00000425707ENST00000336915RARAchr17

38487647

+SKAP1chr17

46214698

-
In-frameENST00000425707ENST00000336915RARAchr17

38487648

+SKAP1chr17

46214699

-
intron-3CDSENST00000254066ENST00000336915RARAchr17

38499119

+SKAP1chr17

46214699

-
intron-3CDSENST00000254066ENST00000584924RARAchr17

38499119

+SKAP1chr17

46214699

-
intron-3CDSENST00000394081ENST00000336915RARAchr17

38487647

+SKAP1chr17

46214698

-
intron-3CDSENST00000394081ENST00000336915RARAchr17

38487648

+SKAP1chr17

46214699

-
intron-3CDSENST00000394081ENST00000584924RARAchr17

38487647

+SKAP1chr17

46214698

-
intron-3CDSENST00000394081ENST00000584924RARAchr17

38487648

+SKAP1chr17

46214699

-
intron-3CDSENST00000394086ENST00000336915RARAchr17

38487647

+SKAP1chr17

46214698

-
intron-3CDSENST00000394086ENST00000336915RARAchr17

38487648

+SKAP1chr17

46214699

-
intron-3CDSENST00000394086ENST00000336915RARAchr17

38499119

+SKAP1chr17

46214699

-
intron-3CDSENST00000394086ENST00000584924RARAchr17

38487647

+SKAP1chr17

46214698

-
intron-3CDSENST00000394086ENST00000584924RARAchr17

38487648

+SKAP1chr17

46214699

-
intron-3CDSENST00000394086ENST00000584924RARAchr17

38499119

+SKAP1chr17

46214699

-
intron-3CDSENST00000394089ENST00000336915RARAchr17

38499119

+SKAP1chr17

46214699

-
intron-3CDSENST00000394089ENST00000584924RARAchr17

38499119

+SKAP1chr17

46214699

-
intron-3CDSENST00000420042ENST00000336915RARAchr17

38487647

+SKAP1chr17

46214698

-
intron-3CDSENST00000420042ENST00000336915RARAchr17

38487648

+SKAP1chr17

46214699

-
intron-3CDSENST00000420042ENST00000336915RARAchr17

38499119

+SKAP1chr17

46214699

-
intron-3CDSENST00000420042ENST00000584924RARAchr17

38487647

+SKAP1chr17

46214698

-
intron-3CDSENST00000420042ENST00000584924RARAchr17

38487648

+SKAP1chr17

46214699

-
intron-3CDSENST00000420042ENST00000584924RARAchr17

38499119

+SKAP1chr17

46214699

-
intron-3CDSENST00000425707ENST00000336915RARAchr17

38499119

+SKAP1chr17

46214699

-
intron-3CDSENST00000425707ENST00000584924RARAchr17

38499119

+SKAP1chr17

46214699

-
intron-3UTRENST00000394081ENST00000336915RARAchr17

38487647

+SKAP1chr17

46211177

-
intron-3UTRENST00000394081ENST00000336915RARAchr17

38487648

+SKAP1chr17

46211178

-
intron-3UTRENST00000394086ENST00000336915RARAchr17

38487647

+SKAP1chr17

46211177

-
intron-3UTRENST00000394086ENST00000336915RARAchr17

38487648

+SKAP1chr17

46211178

-
intron-3UTRENST00000420042ENST00000336915RARAchr17

38487647

+SKAP1chr17

46211177

-
intron-3UTRENST00000420042ENST00000336915RARAchr17

38487648

+SKAP1chr17

46211178

-
intron-intronENST00000394081ENST00000584924RARAchr17

38487647

+SKAP1chr17

46211177

-
intron-intronENST00000394081ENST00000584924RARAchr17

38487648

+SKAP1chr17

46211178

-
intron-intronENST00000394086ENST00000584924RARAchr17

38487647

+SKAP1chr17

46211177

-
intron-intronENST00000394086ENST00000584924RARAchr17

38487648

+SKAP1chr17

46211178

-
intron-intronENST00000420042ENST00000584924RARAchr17

38487647

+SKAP1chr17

46211177

-
intron-intronENST00000420042ENST00000584924RARAchr17

38487648

+SKAP1chr17

46211178

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000254066RARAchr1738487648+ENST00000336915SKAP1chr1746214699-11196334190140
ENST00000394089RARAchr1738487648+ENST00000336915SKAP1chr1746214699-1194708494111127
ENST00000425707RARAchr1738487648+ENST00000336915SKAP1chr1746214699-1190704490107127
ENST00000394081RARAchr1738499119+ENST00000336915SKAP1chr1746214699-991505768376130
ENST00000254066RARAchr1738487647+ENST00000336915SKAP1chr1746214698-11196334190140
ENST00000394089RARAchr1738487647+ENST00000336915SKAP1chr1746214698-1194708494111127
ENST00000425707RARAchr1738487647+ENST00000336915SKAP1chr1746214698-1190704490107127

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000254066ENST00000336915RARAchr1738487648+SKAP1chr1746214699-0.775820730.22417928
ENST00000394089ENST00000336915RARAchr1738487648+SKAP1chr1746214699-0.65336580.3466342
ENST00000425707ENST00000336915RARAchr1738487648+SKAP1chr1746214699-0.687639650.3123604
ENST00000394081ENST00000336915RARAchr1738499119+SKAP1chr1746214699-0.87008590.12991412
ENST00000254066ENST00000336915RARAchr1738487647+SKAP1chr1746214698-0.775820730.22417928
ENST00000394089ENST00000336915RARAchr1738487647+SKAP1chr1746214698-0.65336580.3466342
ENST00000425707ENST00000336915RARAchr1738487647+SKAP1chr1746214698-0.687639650.3123604

Top

Fusion Genomic Features for RARA-SKAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for RARA-SKAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38487648/chr17:46214699)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRARAchr17:38487647chr17:46214698ENST00000254066+2988_15359463.0DNA bindingNuclear receptor
HgeneRARAchr17:38487647chr17:46214698ENST00000394081+1888_1530458.0DNA bindingNuclear receptor
HgeneRARAchr17:38487647chr17:46214698ENST00000394089+2988_15359463.0DNA bindingNuclear receptor
HgeneRARAchr17:38487647chr17:46214698ENST00000425707+2788_15359366.0DNA bindingNuclear receptor
HgeneRARAchr17:38487648chr17:46214699ENST00000254066+2988_15359463.0DNA bindingNuclear receptor
HgeneRARAchr17:38487648chr17:46214699ENST00000394081+1888_1530458.0DNA bindingNuclear receptor
HgeneRARAchr17:38487648chr17:46214699ENST00000394089+2988_15359463.0DNA bindingNuclear receptor
HgeneRARAchr17:38487648chr17:46214699ENST00000425707+2788_15359366.0DNA bindingNuclear receptor
HgeneRARAchr17:38499119chr17:46214699ENST00000254066+1988_1530463.0DNA bindingNuclear receptor
HgeneRARAchr17:38499119chr17:46214699ENST00000394081+1888_15354458.0DNA bindingNuclear receptor
HgeneRARAchr17:38499119chr17:46214699ENST00000394089+1988_1530463.0DNA bindingNuclear receptor
HgeneRARAchr17:38499119chr17:46214699ENST00000425707+1788_1530366.0DNA bindingNuclear receptor
HgeneRARAchr17:38487647chr17:46214698ENST00000254066+29183_41759463.0DomainNR LBD
HgeneRARAchr17:38487647chr17:46214698ENST00000394081+18183_4170458.0DomainNR LBD
HgeneRARAchr17:38487647chr17:46214698ENST00000394089+29183_41759463.0DomainNR LBD
HgeneRARAchr17:38487647chr17:46214698ENST00000425707+27183_41759366.0DomainNR LBD
HgeneRARAchr17:38487648chr17:46214699ENST00000254066+29183_41759463.0DomainNR LBD
HgeneRARAchr17:38487648chr17:46214699ENST00000394081+18183_4170458.0DomainNR LBD
HgeneRARAchr17:38487648chr17:46214699ENST00000394089+29183_41759463.0DomainNR LBD
HgeneRARAchr17:38487648chr17:46214699ENST00000425707+27183_41759366.0DomainNR LBD
HgeneRARAchr17:38499119chr17:46214699ENST00000254066+19183_4170463.0DomainNR LBD
HgeneRARAchr17:38499119chr17:46214699ENST00000394081+18183_41754458.0DomainNR LBD
HgeneRARAchr17:38499119chr17:46214699ENST00000394089+19183_4170463.0DomainNR LBD
HgeneRARAchr17:38499119chr17:46214699ENST00000425707+17183_4170366.0DomainNR LBD
HgeneRARAchr17:38487647chr17:46214698ENST00000254066+29408_41659463.0Motif9aaTAD
HgeneRARAchr17:38487647chr17:46214698ENST00000394081+18408_4160458.0Motif9aaTAD
HgeneRARAchr17:38487647chr17:46214698ENST00000394089+29408_41659463.0Motif9aaTAD
HgeneRARAchr17:38487647chr17:46214698ENST00000425707+27408_41659366.0Motif9aaTAD
HgeneRARAchr17:38487648chr17:46214699ENST00000254066+29408_41659463.0Motif9aaTAD
HgeneRARAchr17:38487648chr17:46214699ENST00000394081+18408_4160458.0Motif9aaTAD
HgeneRARAchr17:38487648chr17:46214699ENST00000394089+29408_41659463.0Motif9aaTAD
HgeneRARAchr17:38487648chr17:46214699ENST00000425707+27408_41659366.0Motif9aaTAD
HgeneRARAchr17:38499119chr17:46214699ENST00000254066+19408_4160463.0Motif9aaTAD
HgeneRARAchr17:38499119chr17:46214699ENST00000394081+18408_41654458.0Motif9aaTAD
HgeneRARAchr17:38499119chr17:46214699ENST00000394089+19408_4160463.0Motif9aaTAD
HgeneRARAchr17:38499119chr17:46214699ENST00000425707+17408_4160366.0Motif9aaTAD
HgeneRARAchr17:38487647chr17:46214698ENST00000254066+29154_18259463.0RegionNote=Hinge
HgeneRARAchr17:38487647chr17:46214698ENST00000254066+291_8759463.0RegionNote=Modulating
HgeneRARAchr17:38487647chr17:46214698ENST00000254066+29404_41959463.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38487647chr17:46214698ENST00000394081+18154_1820458.0RegionNote=Hinge
HgeneRARAchr17:38487647chr17:46214698ENST00000394081+181_870458.0RegionNote=Modulating
HgeneRARAchr17:38487647chr17:46214698ENST00000394081+18404_4190458.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38487647chr17:46214698ENST00000394089+29154_18259463.0RegionNote=Hinge
HgeneRARAchr17:38487647chr17:46214698ENST00000394089+291_8759463.0RegionNote=Modulating
HgeneRARAchr17:38487647chr17:46214698ENST00000394089+29404_41959463.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38487647chr17:46214698ENST00000425707+27154_18259366.0RegionNote=Hinge
HgeneRARAchr17:38487647chr17:46214698ENST00000425707+271_8759366.0RegionNote=Modulating
HgeneRARAchr17:38487647chr17:46214698ENST00000425707+27404_41959366.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38487648chr17:46214699ENST00000254066+29154_18259463.0RegionNote=Hinge
HgeneRARAchr17:38487648chr17:46214699ENST00000254066+291_8759463.0RegionNote=Modulating
HgeneRARAchr17:38487648chr17:46214699ENST00000254066+29404_41959463.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38487648chr17:46214699ENST00000394081+18154_1820458.0RegionNote=Hinge
HgeneRARAchr17:38487648chr17:46214699ENST00000394081+181_870458.0RegionNote=Modulating
HgeneRARAchr17:38487648chr17:46214699ENST00000394081+18404_4190458.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38487648chr17:46214699ENST00000394089+29154_18259463.0RegionNote=Hinge
HgeneRARAchr17:38487648chr17:46214699ENST00000394089+291_8759463.0RegionNote=Modulating
HgeneRARAchr17:38487648chr17:46214699ENST00000394089+29404_41959463.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38487648chr17:46214699ENST00000425707+27154_18259366.0RegionNote=Hinge
HgeneRARAchr17:38487648chr17:46214699ENST00000425707+271_8759366.0RegionNote=Modulating
HgeneRARAchr17:38487648chr17:46214699ENST00000425707+27404_41959366.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38499119chr17:46214699ENST00000254066+19154_1820463.0RegionNote=Hinge
HgeneRARAchr17:38499119chr17:46214699ENST00000254066+191_870463.0RegionNote=Modulating
HgeneRARAchr17:38499119chr17:46214699ENST00000254066+19404_4190463.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38499119chr17:46214699ENST00000394081+18154_18254458.0RegionNote=Hinge
HgeneRARAchr17:38499119chr17:46214699ENST00000394081+181_8754458.0RegionNote=Modulating
HgeneRARAchr17:38499119chr17:46214699ENST00000394081+18404_41954458.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38499119chr17:46214699ENST00000394089+19154_1820463.0RegionNote=Hinge
HgeneRARAchr17:38499119chr17:46214699ENST00000394089+191_870463.0RegionNote=Modulating
HgeneRARAchr17:38499119chr17:46214699ENST00000394089+19404_4190463.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38499119chr17:46214699ENST00000425707+17154_1820366.0RegionNote=Hinge
HgeneRARAchr17:38499119chr17:46214699ENST00000425707+171_870366.0RegionNote=Modulating
HgeneRARAchr17:38499119chr17:46214699ENST00000425707+17404_4190366.0RegionNote=Required for binding corepressor NCOR1
HgeneRARAchr17:38487647chr17:46214698ENST00000254066+29124_14859463.0Zinc fingerNR C4-type
HgeneRARAchr17:38487647chr17:46214698ENST00000254066+2988_10859463.0Zinc fingerNR C4-type
HgeneRARAchr17:38487647chr17:46214698ENST00000394081+18124_1480458.0Zinc fingerNR C4-type
HgeneRARAchr17:38487647chr17:46214698ENST00000394081+1888_1080458.0Zinc fingerNR C4-type
HgeneRARAchr17:38487647chr17:46214698ENST00000394089+29124_14859463.0Zinc fingerNR C4-type
HgeneRARAchr17:38487647chr17:46214698ENST00000394089+2988_10859463.0Zinc fingerNR C4-type
HgeneRARAchr17:38487647chr17:46214698ENST00000425707+27124_14859366.0Zinc fingerNR C4-type
HgeneRARAchr17:38487647chr17:46214698ENST00000425707+2788_10859366.0Zinc fingerNR C4-type
HgeneRARAchr17:38487648chr17:46214699ENST00000254066+29124_14859463.0Zinc fingerNR C4-type
HgeneRARAchr17:38487648chr17:46214699ENST00000254066+2988_10859463.0Zinc fingerNR C4-type
HgeneRARAchr17:38487648chr17:46214699ENST00000394081+18124_1480458.0Zinc fingerNR C4-type
HgeneRARAchr17:38487648chr17:46214699ENST00000394081+1888_1080458.0Zinc fingerNR C4-type
HgeneRARAchr17:38487648chr17:46214699ENST00000394089+29124_14859463.0Zinc fingerNR C4-type
HgeneRARAchr17:38487648chr17:46214699ENST00000394089+2988_10859463.0Zinc fingerNR C4-type
HgeneRARAchr17:38487648chr17:46214699ENST00000425707+27124_14859366.0Zinc fingerNR C4-type
HgeneRARAchr17:38487648chr17:46214699ENST00000425707+2788_10859366.0Zinc fingerNR C4-type
HgeneRARAchr17:38499119chr17:46214699ENST00000254066+19124_1480463.0Zinc fingerNR C4-type
HgeneRARAchr17:38499119chr17:46214699ENST00000254066+1988_1080463.0Zinc fingerNR C4-type
HgeneRARAchr17:38499119chr17:46214699ENST00000394081+18124_14854458.0Zinc fingerNR C4-type
HgeneRARAchr17:38499119chr17:46214699ENST00000394081+1888_10854458.0Zinc fingerNR C4-type
HgeneRARAchr17:38499119chr17:46214699ENST00000394089+19124_1480463.0Zinc fingerNR C4-type
HgeneRARAchr17:38499119chr17:46214699ENST00000394089+1988_1080463.0Zinc fingerNR C4-type
HgeneRARAchr17:38499119chr17:46214699ENST00000425707+17124_1480366.0Zinc fingerNR C4-type
HgeneRARAchr17:38499119chr17:46214699ENST00000425707+1788_1080366.0Zinc fingerNR C4-type
TgeneSKAP1chr17:38487647chr17:46214698ENST000003369151013220_230326448.0Compositional biasNote=Poly-Glu
TgeneSKAP1chr17:38487647chr17:46214698ENST000005849241012220_230326360.0Compositional biasNote=Poly-Glu
TgeneSKAP1chr17:38487648chr17:46214699ENST000003369151013220_230326448.0Compositional biasNote=Poly-Glu
TgeneSKAP1chr17:38487648chr17:46214699ENST000005849241012220_230326360.0Compositional biasNote=Poly-Glu
TgeneSKAP1chr17:38499119chr17:46214699ENST000003369151013220_230326448.0Compositional biasNote=Poly-Glu
TgeneSKAP1chr17:38499119chr17:46214699ENST000005849241012220_230326360.0Compositional biasNote=Poly-Glu
TgeneSKAP1chr17:38487647chr17:46214698ENST000003369151013107_210326448.0DomainPH
TgeneSKAP1chr17:38487647chr17:46214698ENST000003369151013294_355326448.0DomainSH3
TgeneSKAP1chr17:38487647chr17:46214698ENST000005849241012107_210326360.0DomainPH
TgeneSKAP1chr17:38487647chr17:46214698ENST000005849241012294_355326360.0DomainSH3
TgeneSKAP1chr17:38487648chr17:46214699ENST000003369151013107_210326448.0DomainPH
TgeneSKAP1chr17:38487648chr17:46214699ENST000003369151013294_355326448.0DomainSH3
TgeneSKAP1chr17:38487648chr17:46214699ENST000005849241012107_210326360.0DomainPH
TgeneSKAP1chr17:38487648chr17:46214699ENST000005849241012294_355326360.0DomainSH3
TgeneSKAP1chr17:38499119chr17:46214699ENST000003369151013107_210326448.0DomainPH
TgeneSKAP1chr17:38499119chr17:46214699ENST000003369151013294_355326448.0DomainSH3
TgeneSKAP1chr17:38499119chr17:46214699ENST000005849241012107_210326360.0DomainPH
TgeneSKAP1chr17:38499119chr17:46214699ENST000005849241012294_355326360.0DomainSH3


Top

Fusion Gene Sequence for RARA-SKAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72315_72315_1_RARA-SKAP1_RARA_chr17_38487647_ENST00000254066_SKAP1_chr17_46214698_ENST00000336915_length(transcript)=1119nt_BP=633nt
CAGAAGCAGGGGGGAATCCTGAATCGAGCTGAGAGGGCTTCCCCGGTTCTCCTGGGAACCCCATCGGCCCCCTGCCAGCACACACCTGAG
CAGCATCACAGGACATGGCCCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGA
CCTTCCCAGGAAAAGTGCCAGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGG
GTGGGGGCTCCAGGAGACTGAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCT
GGGCCCAGGCCCCATGCCCCGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGC
TTGGCATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCC
CCCCTATGCTGGGTGGACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAG
CCAGAGTATAACATGTATGGCTGGTGGGTGGGAGAACTGAACAGCCTCGTTGGGATTGTTCCAAAGGAGTATCTCACCACTGCCTTTGAA
GTGGAAGAAAGATGAAACCCAGGAAATATATTCTTCCCTCTCTCCTGCCTTTATGAGGAAACTGATCATCAAAAGTTCCCACTCCCTACT
TCTGCCACCCCACCAACGCCTTGGACTCCTCTCTTTGCTGAAGAGACCCAAGTCTCTTGACACCTCAGAGTGACTGTAAGCTACCAGTAA
GACAAGTGGGAAGAGGCACGTTCATCAAACCTGTTACTAAACCAGCCTAGTCATAGCTCATCCCCATCTCTAAATGTGTCCACACAACCA
CATCTGCCTTTTCCACAAGCTTTTCACAAAGAAGGTGAGAGAGAAGGAAACCTTGGGAGGAGGACATTACTGGTTGTTCTGGCTGGTTTG

>72315_72315_1_RARA-SKAP1_RARA_chr17_38487647_ENST00000254066_SKAP1_chr17_46214698_ENST00000336915_length(amino acids)=140AA_BP=
MAGGSGGLQTTPPRGMGPGPRWGLGGQPTRPVLELLSKEGRLISVSWSPHPSWGPGGLGDVSRAGPLVKQFCELALFLGRSRAGLQGTKK

--------------------------------------------------------------
>72315_72315_2_RARA-SKAP1_RARA_chr17_38487647_ENST00000394089_SKAP1_chr17_46214698_ENST00000336915_length(transcript)=1194nt_BP=708nt
GTGACTCGCTATGGCCGCTGCCATCGCCCCGCGCCCCTGAGCCGCGGCCCCCTGGACGGCTCCTCTCCCGGGACCCCGCACCCTGATGCC
GAGCAGCACCAGGGCGCCGGGTTAGGGCAGACGCTGTGCTCGCTGGCACCCCGAACGGGTTGCTTCCCCCGCTGCGAGCATCACAGGACA
TGGCCCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGACCTTCCCAGGAAAAG
TGCCAGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGGGTGGGGGCTCCAGGA
GACTGAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCTGGGCCCAGGCCCCAT
GCCCCGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGCTTGGCATGGCCAGCA
ACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTG
GACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCAGAGTATAACATG
TATGGCTGGTGGGTGGGAGAACTGAACAGCCTCGTTGGGATTGTTCCAAAGGAGTATCTCACCACTGCCTTTGAAGTGGAAGAAAGATGA
AACCCAGGAAATATATTCTTCCCTCTCTCCTGCCTTTATGAGGAAACTGATCATCAAAAGTTCCCACTCCCTACTTCTGCCACCCCACCA
ACGCCTTGGACTCCTCTCTTTGCTGAAGAGACCCAAGTCTCTTGACACCTCAGAGTGACTGTAAGCTACCAGTAAGACAAGTGGGAAGAG
GCACGTTCATCAAACCTGTTACTAAACCAGCCTAGTCATAGCTCATCCCCATCTCTAAATGTGTCCACACAACCACATCTGCCTTTTCCA
CAAGCTTTTCACAAAGAAGGTGAGAGAGAAGGAAACCTTGGGAGGAGGACATTACTGGTTGTTCTGGCTGGTTTGAAAAGCACAAATAAA

>72315_72315_2_RARA-SKAP1_RARA_chr17_38487647_ENST00000394089_SKAP1_chr17_46214698_ENST00000336915_length(amino acids)=127AA_BP=
MAGGSGGLQTTPPRGMGPGPRWGLGGQPTRPVLELLSKEGRLISVSWSPHPSWGPGGLGDVSRAGPLVKQFCELALFLGRSRAGLQGTKK

--------------------------------------------------------------
>72315_72315_3_RARA-SKAP1_RARA_chr17_38487647_ENST00000425707_SKAP1_chr17_46214698_ENST00000336915_length(transcript)=1190nt_BP=704nt
CTCGCTATGGCCGCTGCCATCGCCCCGCGCCCCTGAGCCGCGGCCCCCTGGACGGCTCCTCTCCCGGGACCCCGCACCCTGATGCCGAGC
AGCACCAGGGCGCCGGGTTAGGGCAGACGCTGTGCTCGCTGGCACCCCGAACGGGTTGCTTCCCCCGCTGCGAGCATCACAGGACATGGC
CCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGACCTTCCCAGGAAAAGTGCC
AGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGGGTGGGGGCTCCAGGAGACT
GAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCTGGGCCCAGGCCCCATGCCC
CGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGCTTGGCATGGCCAGCAACAG
CAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTGGACT
CTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCAGAGTATAACATGTATG
GCTGGTGGGTGGGAGAACTGAACAGCCTCGTTGGGATTGTTCCAAAGGAGTATCTCACCACTGCCTTTGAAGTGGAAGAAAGATGAAACC
CAGGAAATATATTCTTCCCTCTCTCCTGCCTTTATGAGGAAACTGATCATCAAAAGTTCCCACTCCCTACTTCTGCCACCCCACCAACGC
CTTGGACTCCTCTCTTTGCTGAAGAGACCCAAGTCTCTTGACACCTCAGAGTGACTGTAAGCTACCAGTAAGACAAGTGGGAAGAGGCAC
GTTCATCAAACCTGTTACTAAACCAGCCTAGTCATAGCTCATCCCCATCTCTAAATGTGTCCACACAACCACATCTGCCTTTTCCACAAG
CTTTTCACAAAGAAGGTGAGAGAGAAGGAAACCTTGGGAGGAGGACATTACTGGTTGTTCTGGCTGGTTTGAAAAGCACAAATAAACTTG

>72315_72315_3_RARA-SKAP1_RARA_chr17_38487647_ENST00000425707_SKAP1_chr17_46214698_ENST00000336915_length(amino acids)=127AA_BP=
MAGGSGGLQTTPPRGMGPGPRWGLGGQPTRPVLELLSKEGRLISVSWSPHPSWGPGGLGDVSRAGPLVKQFCELALFLGRSRAGLQGTKK

--------------------------------------------------------------
>72315_72315_4_RARA-SKAP1_RARA_chr17_38487648_ENST00000254066_SKAP1_chr17_46214699_ENST00000336915_length(transcript)=1119nt_BP=633nt
CAGAAGCAGGGGGGAATCCTGAATCGAGCTGAGAGGGCTTCCCCGGTTCTCCTGGGAACCCCATCGGCCCCCTGCCAGCACACACCTGAG
CAGCATCACAGGACATGGCCCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGA
CCTTCCCAGGAAAAGTGCCAGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGG
GTGGGGGCTCCAGGAGACTGAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCT
GGGCCCAGGCCCCATGCCCCGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGC
TTGGCATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCC
CCCCTATGCTGGGTGGACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAG
CCAGAGTATAACATGTATGGCTGGTGGGTGGGAGAACTGAACAGCCTCGTTGGGATTGTTCCAAAGGAGTATCTCACCACTGCCTTTGAA
GTGGAAGAAAGATGAAACCCAGGAAATATATTCTTCCCTCTCTCCTGCCTTTATGAGGAAACTGATCATCAAAAGTTCCCACTCCCTACT
TCTGCCACCCCACCAACGCCTTGGACTCCTCTCTTTGCTGAAGAGACCCAAGTCTCTTGACACCTCAGAGTGACTGTAAGCTACCAGTAA
GACAAGTGGGAAGAGGCACGTTCATCAAACCTGTTACTAAACCAGCCTAGTCATAGCTCATCCCCATCTCTAAATGTGTCCACACAACCA
CATCTGCCTTTTCCACAAGCTTTTCACAAAGAAGGTGAGAGAGAAGGAAACCTTGGGAGGAGGACATTACTGGTTGTTCTGGCTGGTTTG

>72315_72315_4_RARA-SKAP1_RARA_chr17_38487648_ENST00000254066_SKAP1_chr17_46214699_ENST00000336915_length(amino acids)=140AA_BP=
MAGGSGGLQTTPPRGMGPGPRWGLGGQPTRPVLELLSKEGRLISVSWSPHPSWGPGGLGDVSRAGPLVKQFCELALFLGRSRAGLQGTKK

--------------------------------------------------------------
>72315_72315_5_RARA-SKAP1_RARA_chr17_38487648_ENST00000394089_SKAP1_chr17_46214699_ENST00000336915_length(transcript)=1194nt_BP=708nt
GTGACTCGCTATGGCCGCTGCCATCGCCCCGCGCCCCTGAGCCGCGGCCCCCTGGACGGCTCCTCTCCCGGGACCCCGCACCCTGATGCC
GAGCAGCACCAGGGCGCCGGGTTAGGGCAGACGCTGTGCTCGCTGGCACCCCGAACGGGTTGCTTCCCCCGCTGCGAGCATCACAGGACA
TGGCCCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGACCTTCCCAGGAAAAG
TGCCAGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGGGTGGGGGCTCCAGGA
GACTGAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCTGGGCCCAGGCCCCAT
GCCCCGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGCTTGGCATGGCCAGCA
ACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTG
GACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCAGAGTATAACATG
TATGGCTGGTGGGTGGGAGAACTGAACAGCCTCGTTGGGATTGTTCCAAAGGAGTATCTCACCACTGCCTTTGAAGTGGAAGAAAGATGA
AACCCAGGAAATATATTCTTCCCTCTCTCCTGCCTTTATGAGGAAACTGATCATCAAAAGTTCCCACTCCCTACTTCTGCCACCCCACCA
ACGCCTTGGACTCCTCTCTTTGCTGAAGAGACCCAAGTCTCTTGACACCTCAGAGTGACTGTAAGCTACCAGTAAGACAAGTGGGAAGAG
GCACGTTCATCAAACCTGTTACTAAACCAGCCTAGTCATAGCTCATCCCCATCTCTAAATGTGTCCACACAACCACATCTGCCTTTTCCA
CAAGCTTTTCACAAAGAAGGTGAGAGAGAAGGAAACCTTGGGAGGAGGACATTACTGGTTGTTCTGGCTGGTTTGAAAAGCACAAATAAA

>72315_72315_5_RARA-SKAP1_RARA_chr17_38487648_ENST00000394089_SKAP1_chr17_46214699_ENST00000336915_length(amino acids)=127AA_BP=
MAGGSGGLQTTPPRGMGPGPRWGLGGQPTRPVLELLSKEGRLISVSWSPHPSWGPGGLGDVSRAGPLVKQFCELALFLGRSRAGLQGTKK

--------------------------------------------------------------
>72315_72315_6_RARA-SKAP1_RARA_chr17_38487648_ENST00000425707_SKAP1_chr17_46214699_ENST00000336915_length(transcript)=1190nt_BP=704nt
CTCGCTATGGCCGCTGCCATCGCCCCGCGCCCCTGAGCCGCGGCCCCCTGGACGGCTCCTCTCCCGGGACCCCGCACCCTGATGCCGAGC
AGCACCAGGGCGCCGGGTTAGGGCAGACGCTGTGCTCGCTGGCACCCCGAACGGGTTGCTTCCCCCGCTGCGAGCATCACAGGACATGGC
CCCCTCAGCCACCTAGCTGGGGCCCATCTAGGAGTGGCATCTTTTTTGGTGCCCTGAAGGCCAGCTCTGGACCTTCCCAGGAAAAGTGCC
AGCTCACAGAACTGCTTGACCAAAGGACCGGCTCTTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGGGTGGGGGCTCCAGGAGACT
GAGATTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAACCCCATCTGGGCCCAGGCCCCATGCCC
CGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCCCTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGCTTGGCATGGCCAGCAACAG
CAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTGGACT
CTCCCCGCCAGGCGCTCTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCAGAGTATAACATGTATG
GCTGGTGGGTGGGAGAACTGAACAGCCTCGTTGGGATTGTTCCAAAGGAGTATCTCACCACTGCCTTTGAAGTGGAAGAAAGATGAAACC
CAGGAAATATATTCTTCCCTCTCTCCTGCCTTTATGAGGAAACTGATCATCAAAAGTTCCCACTCCCTACTTCTGCCACCCCACCAACGC
CTTGGACTCCTCTCTTTGCTGAAGAGACCCAAGTCTCTTGACACCTCAGAGTGACTGTAAGCTACCAGTAAGACAAGTGGGAAGAGGCAC
GTTCATCAAACCTGTTACTAAACCAGCCTAGTCATAGCTCATCCCCATCTCTAAATGTGTCCACACAACCACATCTGCCTTTTCCACAAG
CTTTTCACAAAGAAGGTGAGAGAGAAGGAAACCTTGGGAGGAGGACATTACTGGTTGTTCTGGCTGGTTTGAAAAGCACAAATAAACTTG

>72315_72315_6_RARA-SKAP1_RARA_chr17_38487648_ENST00000425707_SKAP1_chr17_46214699_ENST00000336915_length(amino acids)=127AA_BP=
MAGGSGGLQTTPPRGMGPGPRWGLGGQPTRPVLELLSKEGRLISVSWSPHPSWGPGGLGDVSRAGPLVKQFCELALFLGRSRAGLQGTKK

--------------------------------------------------------------
>72315_72315_7_RARA-SKAP1_RARA_chr17_38499119_ENST00000394081_SKAP1_chr17_46214699_ENST00000336915_length(transcript)=991nt_BP=505nt
AGCCGCTGTACTCTGCCTCGGACGCCACGAGACTCTAGACGGGAGTCCCCTCGAGGTGAAGCCGCTGAGTTCCCGGGCCCCGCCAGGCTT
CCCTGGGAGAGCCGACGGACCCCCCCTCCCAGCACACACAACTTCCCTGCTTTTCACCGGGACTGGCGGAGCGGCCGGCGGACTTAGACG
CGGGGACTTCAGGGCAGGGGGCGCCCCCTGCCCGGGTCACCAGTCGGGGCGAGGGGACGTCTCCTCTCCCCCAGCTGCTCTGCTCGGATG
GCGCCGCCGGCTGAGTGACGGGGGCGGCGCGCAGGACTTCCCAGCTCGGACCTCTTGCCTTCGAGGGGAAAGATGTACGAGAGTGTAGAA
GTGGGGGGTCCCACCCCTAATCCCTTCCTAGTGGTGGATTTTTATAACCAGAACCGGGCCTGTTTGCTCCCAGAGAAGGGGCTCCCCGCC
CCGGGTCCGTACTCCACCCCGCTCCGGACTCCGCTTTGGAATGGCTCAAACCACTGAGTATAACATGTATGGCTGGTGGGTGGGAGAACT
GAACAGCCTCGTTGGGATTGTTCCAAAGGAGTATCTCACCACTGCCTTTGAAGTGGAAGAAAGATGAAACCCAGGAAATATATTCTTCCC
TCTCTCCTGCCTTTATGAGGAAACTGATCATCAAAAGTTCCCACTCCCTACTTCTGCCACCCCACCAACGCCTTGGACTCCTCTCTTTGC
TGAAGAGACCCAAGTCTCTTGACACCTCAGAGTGACTGTAAGCTACCAGTAAGACAAGTGGGAAGAGGCACGTTCATCAAACCTGTTACT
AAACCAGCCTAGTCATAGCTCATCCCCATCTCTAAATGTGTCCACACAACCACATCTGCCTTTTCCACAAGCTTTTCACAAAGAAGGTGA
GAGAGAAGGAAACCTTGGGAGGAGGACATTACTGGTTGTTCTGGCTGGTTTGAAAAGCACAAATAAACTTGGGATGTGGTTCCTTGCCAT

>72315_72315_7_RARA-SKAP1_RARA_chr17_38499119_ENST00000394081_SKAP1_chr17_46214699_ENST00000336915_length(amino acids)=130AA_BP=1
MVAYSHSEVSRDLGLFSKERSPRRWWGGRSREWELLMISFLIKAGEREEYISWVSSFFHFKGSGEILLWNNPNEAVQFSHPPAIHVILSG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RARA-SKAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSKAP1chr17:38487647chr17:46214698ENST000003369151013290_295326.0448.0FYB1
TgeneSKAP1chr17:38487647chr17:46214698ENST000005849241012290_295326.0360.0FYB1
TgeneSKAP1chr17:38487648chr17:46214699ENST000003369151013290_295326.0448.0FYB1
TgeneSKAP1chr17:38487648chr17:46214699ENST000005849241012290_295326.0360.0FYB1
TgeneSKAP1chr17:38499119chr17:46214699ENST000003369151013290_295326.0448.0FYB1
TgeneSKAP1chr17:38499119chr17:46214699ENST000005849241012290_295326.0360.0FYB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for RARA-SKAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for RARA-SKAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource