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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:RASA1-RAPGEF6 (FusionGDB2 ID:72374)

Fusion Gene Summary for RASA1-RAPGEF6

check button Fusion gene summary
Fusion gene informationFusion gene name: RASA1-RAPGEF6
Fusion gene ID: 72374
HgeneTgene
Gene symbol

RASA1

RAPGEF6

Gene ID

8831

51735

Gene namesynaptic Ras GTPase activating protein 1Rap guanine nucleotide exchange factor 6
SynonymsMRD5|RASA1|RASA5|SYNGAPKIA001LB|PDZ-GEF2|PDZGEF2|RA-GEF-2|RAGEF2
Cytomap

6p21.32

5q31.1

Type of geneprotein-codingprotein-coding
Descriptionras/Rap GTPase-activating protein SynGAPRas GTPase-activating protein SynGAPneuronal RasGAPsynaptic Ras GTPase activating protein 1 homologsynaptic Ras GTPase activating protein, 135kDarap guanine nucleotide exchange factor 6PDZ domain containing guanine nucleotide exchange factor (GEF) 2PDZ domain-containing guanine nucleotide exchange factor 2PDZ domain-containing guanine nucleotide exchange factor IRap guanine nucleotide exchange
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000274376, ENST00000456692, 
ENST00000506290, ENST00000512763, 
ENST00000503398, ENST00000510071, 
ENST00000296859, ENST00000307984, 
ENST00000308008, ENST00000507093, 
ENST00000509018, ENST00000512052, 
Fusion gene scores* DoF score9 X 7 X 6=3782 X 2 X 2=8
# samples 92
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: RASA1 [Title/Abstract] AND RAPGEF6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRASA1(86564807)-RAPGEF6(130782396), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RASA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAPGEF6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-4397-01ARASA1chr5

86564807

+RAPGEF6chr5

130782396

-


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Fusion Gene ORF analysis for RASA1-RAPGEF6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000274376ENST00000503398RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5CDS-intronENST00000274376ENST00000510071RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000456692ENST00000296859RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000456692ENST00000307984RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000456692ENST00000308008RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000456692ENST00000507093RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000456692ENST00000509018RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000456692ENST00000512052RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000506290ENST00000296859RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000506290ENST00000307984RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000506290ENST00000308008RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000506290ENST00000507093RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000506290ENST00000509018RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000506290ENST00000512052RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000512763ENST00000296859RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000512763ENST00000307984RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000512763ENST00000308008RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000512763ENST00000507093RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000512763ENST00000509018RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-3CDSENST00000512763ENST00000512052RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-intronENST00000456692ENST00000503398RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-intronENST00000456692ENST00000510071RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-intronENST00000506290ENST00000503398RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-intronENST00000506290ENST00000510071RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-intronENST00000512763ENST00000503398RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
5UTR-intronENST00000512763ENST00000510071RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
In-frameENST00000274376ENST00000296859RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
In-frameENST00000274376ENST00000307984RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
In-frameENST00000274376ENST00000308008RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
In-frameENST00000274376ENST00000507093RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
In-frameENST00000274376ENST00000509018RASA1chr5

86564807

+RAPGEF6chr5

130782396

-
In-frameENST00000274376ENST00000512052RASA1chr5

86564807

+RAPGEF6chr5

130782396

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000274376RASA1chr586564807+ENST00000509018RAPGEF6chr5130782396-605411035642708714
ENST00000274376RASA1chr586564807+ENST00000307984RAPGEF6chr5130782396-573711035642393609
ENST00000274376RASA1chr586564807+ENST00000507093RAPGEF6chr5130782396-342411035642393609
ENST00000274376RASA1chr586564807+ENST00000296859RAPGEF6chr5130782396-341611035642708714
ENST00000274376RASA1chr586564807+ENST00000512052RAPGEF6chr5130782396-226911035642078504
ENST00000274376RASA1chr586564807+ENST00000308008RAPGEF6chr5130782396-207911035642078504

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000274376ENST00000509018RASA1chr586564807+RAPGEF6chr5130782396-0.0005065820.99949336
ENST00000274376ENST00000307984RASA1chr586564807+RAPGEF6chr5130782396-0.0004570050.9995431
ENST00000274376ENST00000507093RASA1chr586564807+RAPGEF6chr5130782396-0.0028467450.9971533
ENST00000274376ENST00000296859RASA1chr586564807+RAPGEF6chr5130782396-0.003476960.996523
ENST00000274376ENST00000512052RASA1chr586564807+RAPGEF6chr5130782396-0.0044630970.9955369
ENST00000274376ENST00000308008RASA1chr586564807+RAPGEF6chr5130782396-0.0084579080.9915421

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Fusion Genomic Features for RASA1-RAPGEF6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RASA1-RAPGEF6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:86564807/chr5:130782396)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRASA1chr5:86564807chr5:130782396ENST00000274376+125135_1411791048.0Compositional biasNote=Poly-Pro
HgeneRASA1chr5:86564807chr5:130782396ENST00000274376+125163_1681791048.0Compositional biasNote=Poly-Glu
HgeneRASA1chr5:86564807chr5:130782396ENST00000274376+12517_221791048.0Compositional biasNote=Poly-Gly
TgeneRAPGEF6chr5:86564807chr5:130782396ENST0000029685921291229_144010741610.0Compositional biasNote=Ser-rich
TgeneRAPGEF6chr5:86564807chr5:130782396ENST0000030798422291229_144010791510.0Compositional biasNote=Ser-rich
TgeneRAPGEF6chr5:86564807chr5:130782396ENST0000030800820251229_144010661392.0Compositional biasNote=Ser-rich
TgeneRAPGEF6chr5:86564807chr5:130782396ENST0000050709321281229_144010741505.0Compositional biasNote=Ser-rich
TgeneRAPGEF6chr5:86564807chr5:130782396ENST0000050901820281229_144010661602.0Compositional biasNote=Ser-rich
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000005100710181229_14400828.0Compositional biasNote=Ser-rich
TgeneRAPGEF6chr5:86564807chr5:130782396ENST00000510071018412_5260828.0DomainN-terminal Ras-GEF
TgeneRAPGEF6chr5:86564807chr5:130782396ENST00000510071018530_6150828.0DomainPDZ
TgeneRAPGEF6chr5:86564807chr5:130782396ENST00000510071018749_8350828.0DomainRas-associating
TgeneRAPGEF6chr5:86564807chr5:130782396ENST00000510071018860_10880828.0DomainRas-GEF
TgeneRAPGEF6chr5:86564807chr5:130782396ENST00000510071018280_3990828.0Nucleotide bindingNote=cNMP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRASA1chr5:86564807chr5:130782396ENST00000456692+125135_1410871.0Compositional biasNote=Poly-Pro
HgeneRASA1chr5:86564807chr5:130782396ENST00000456692+125163_1680871.0Compositional biasNote=Poly-Glu
HgeneRASA1chr5:86564807chr5:130782396ENST00000456692+12517_220871.0Compositional biasNote=Poly-Gly
HgeneRASA1chr5:86564807chr5:130782396ENST00000274376+125181_2721791048.0DomainSH2 1
HgeneRASA1chr5:86564807chr5:130782396ENST00000274376+125279_3411791048.0DomainSH3
HgeneRASA1chr5:86564807chr5:130782396ENST00000274376+125351_4411791048.0DomainSH2 2
HgeneRASA1chr5:86564807chr5:130782396ENST00000274376+125474_5771791048.0DomainPH
HgeneRASA1chr5:86564807chr5:130782396ENST00000274376+125577_6901791048.0DomainC2
HgeneRASA1chr5:86564807chr5:130782396ENST00000274376+125748_9421791048.0DomainRas-GAP
HgeneRASA1chr5:86564807chr5:130782396ENST00000456692+125181_2720871.0DomainSH2 1
HgeneRASA1chr5:86564807chr5:130782396ENST00000456692+125279_3410871.0DomainSH3
HgeneRASA1chr5:86564807chr5:130782396ENST00000456692+125351_4410871.0DomainSH2 2
HgeneRASA1chr5:86564807chr5:130782396ENST00000456692+125474_5770871.0DomainPH
HgeneRASA1chr5:86564807chr5:130782396ENST00000456692+125577_6900871.0DomainC2
HgeneRASA1chr5:86564807chr5:130782396ENST00000456692+125748_9420871.0DomainRas-GAP
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000002968592129412_52610741610.0DomainN-terminal Ras-GEF
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000002968592129530_61510741610.0DomainPDZ
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000002968592129749_83510741610.0DomainRas-associating
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000002968592129860_108810741610.0DomainRas-GEF
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000003079842229412_52610791510.0DomainN-terminal Ras-GEF
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000003079842229530_61510791510.0DomainPDZ
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000003079842229749_83510791510.0DomainRas-associating
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000003079842229860_108810791510.0DomainRas-GEF
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000003080082025412_52610661392.0DomainN-terminal Ras-GEF
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000003080082025530_61510661392.0DomainPDZ
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000003080082025749_83510661392.0DomainRas-associating
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000003080082025860_108810661392.0DomainRas-GEF
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000005070932128412_52610741505.0DomainN-terminal Ras-GEF
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000005070932128530_61510741505.0DomainPDZ
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000005070932128749_83510741505.0DomainRas-associating
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000005070932128860_108810741505.0DomainRas-GEF
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000005090182028412_52610661602.0DomainN-terminal Ras-GEF
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000005090182028530_61510661602.0DomainPDZ
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000005090182028749_83510661602.0DomainRas-associating
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000005090182028860_108810661602.0DomainRas-GEF
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000002968592129280_39910741610.0Nucleotide bindingNote=cNMP
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000003079842229280_39910791510.0Nucleotide bindingNote=cNMP
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000003080082025280_39910661392.0Nucleotide bindingNote=cNMP
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000005070932128280_39910741505.0Nucleotide bindingNote=cNMP
TgeneRAPGEF6chr5:86564807chr5:130782396ENST000005090182028280_39910661602.0Nucleotide bindingNote=cNMP


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Fusion Gene Sequence for RASA1-RAPGEF6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72374_72374_1_RASA1-RAPGEF6_RASA1_chr5_86564807_ENST00000274376_RAPGEF6_chr5_130782396_ENST00000296859_length(transcript)=3416nt_BP=1103nt
CTGAGAGCTCCAGGTAGTGAGCAGTTCAGTCGATTTCCTCGTTACCCCGCCCCCCTTTCTCTTGCCCCCCCACCCCTCTCATCTGCCTGG
TGGAGGATGAAGCGGCTGCAGTGGCCCCAGCCTCAGCAGCGGCACCGGCGGTGGCTGCGGTGTGGGTGGCCGGAACTGGGGTGGTGAAGA
AGCGGTGGTGGCGGCTGAAGGAGCGGTAGCAGCCTCAGCCTCTTTCCCTGTGCTTCCTTTCCTCTTTAGTGCAGCGAGGAAGTTTTCGCT
TCTGTACATGTGTTTGTGTGCGTGAGTGTGGGTGTGTGCGGTGAGGTTTGGGTGGCGTTTGTGCAGGCGTTGGGTTTTTTGCCCACTTGG
CTTCCCGTAACCCAGGCAGCTGGGGAGCCTGGGCTGTGGCCCTAGGAGGGGGCGCGGCGGCGGGCTCTCTCCTTTTGTTGTTGTTTCCTC
AGCCTGGGGAGCTGAAGGGGAGACGCGTCTGGGTGGGGCTGCTCGGAGCCCGGGCCTGGTGGCCCCTGGGGCTCCCGGGCGGGCAGGGTA
GGGCAGAGTAGAGCGGGCTTCAACATGATGGCGGCCGAGGCCGGCAGTGAGGAGGGCGGCCCGGTAACAGCCGGAGCTGGAGGAGGCGGC
GCGGCAGCGGGCTCCAGTGCCTATCCCGCAGTGTGTCGGGTGAAGATACCCGCGGCCCTGCCTGTGGCAGCCGCCCCCTATCCTGGGCTG
GTGGAGACCGGAGTGGCTGGAACTCTGGGTGGCGGAGCCGCTTTGGGGTCAGAGTTCCTAGGAGCCGGGTCTGTGGCAGGGGCACTGGGG
GGAGCTGGACTGACAGGGGGAGGTACTGCTGCTGGCGTAGCTGGTGCTGCTGCTGGCGTGGCCGGTGCTGCTGTTGCTGGACCTAGTGGA
GACATGGCTCTCACCAAACTGCCCACTTCGTTGCTTGCTGAGACTCTCGGGCCAGGCGGCGGTTTTCCCCCTCTGCCCCCTCCCCCTTAC
CTGCCCCCTTTGGGGGCGGGCCTCGGGACAGTGGACGAAGGTGACTCTCTGGATGGACCAGAATACGAGGAGGAAGAGGTGGCCATACCG
TTGACCGCTCCTCCAACTAACCAGTCACTGAGTCAAGGAAGCACAAATTCAAACATGCTGGATGTTCAGGGAGGTGCTCACAAAAAAAGG
GCACGCCGCAGCTCTCTGCTTAATGCCAAGAAGCTATATGAGGATGCCCAAATGGCAAGGAAGGTGAAGCAGTATCTTTCCAGTCTCGAT
GTAGAGACAGATGAGGAGAAGTTCCAGATGATGTCATTACAGTGGGAGCCTGCATATGGTACCTTGACCAAGAATTTAAGTGAGAAAAGA
TCAGCCAAATCATCTGAAATGTCTCCAGTGCCTATGAGGTCAGCTGGCCAAACAACTAAAGCCCACTTGCATCAACCCCACAGAGTAAGC
CAGGTGCTTCAGGTGCCAGCTGTTAATTTGCACCCCATCAGGAAGAAGGGACAAACAAAAGACCCTGCACTGAATACAAGTTTACCTCAG
AAAGTTTTAGGAACAACTGAAGAAATAAGTGGTAAGAAGCATACAGAAGACACTATTTCTGTGGCGTCATCTTTACATTCTAGTCCTCCT
GCATCTCCTCAAGGCTCCCCTCACAAAGGTTACACACTTATTCCATCAGCTAAATCTGACAACTTGTCTGACTCCAGCCATAGTGAGATT
TCTTCACGGTCCAGCATCGTGAGCAATTGTTCTGTTGACTCCATGTCTGCAGCTCTACAGGATGAACGGTGTTCCTCTCAGGCCCTGGCA
GTCCCTGAATCCACTGGGGCATTGGAAAAGACAGAGCACGCTTCAGGGATAGGAGATCATAGTCAACATGGCCCTGGGTGGACACTCTTG
AAGCCATCTCTAATCAAGTGTTTAGCTGTCTCATCGTCTGTGAGCAATGAAGAGATTTCTCAAGAGCATATCATTATAGAAGCAGCTGAC
AGTGGTCGTGGAAGTTGGACTTCGTGTTCAAGCAGCTCCCATGACAACTTCCAAAGCCTTCCAAACCCAAAAAGCTGGGATTTTTTGAAC
TCTTACAGACATACCCATTTGGATGACCCCATTGCTGAAGTTGAACCCACTGACTCTGAGCCCTATTCCTGTTCTAAAAGCTGCTCTAGA
ACTTGTGGGCAGTGTAAAGGAAGCCTAGAGAGAAAGAGTTGGACCTCCTCCAGTTCTCTGTCTGACACGTATGAACCAAACTATGGGACA
GTTAAACAGAGAGTATTGGAGAGCACCCCAGCTGAGTCATCTGAAGGCTTGGACCCCAAGGATGCCACTGACCCAGTTTATAAAACTGTC
ACTTCAAGTACAGAAAAGGGCTTGATTGTGTACTGTGTCACCTCACCCAAGAAGGACGATAGGTATAGGGAGCCACCTCCCACTCCTCCA
GGATATTTGGGGATTTCTTTAGCGGACCTAAAGGAAGGACCCCACACACACCTAAAACCTCCAGATTATAGTGTGGCAGTGCAGAGGTCA
AAGATGATGCATAACAGCCTCTCTAGACTGCCACCAGCTTCTCTCAGTAGCAACCTCGTGGCCTGTGTTCCATCGAAGATTGTAACTCAG
CCTCAGAGGCATAATTTGCAGCCATTCCATCCTAAACTAGGAGATGTGACTGATGCAGATAGCGAAGCAGATGAAAATGAACAAGTTTCA
GCAGTCTAGCCTTTGGATGACCTATTTGAAAACCACTGAAAGTCGTGGAGGAATGGGCAAGAACCACCTCATGATTCTGCAGGCCATTGC
TAACGAACAGCTCATTGCTACAACCAGTCCAGAGGTTTTATTCCCTCTACTCCGAGCAATGAAATAGACCTGAGTTATGCTTCCTTTCAT
TTAATTTCTGCAGATAAATAGTTTCCTGAGCAATGGATGCTATGCCTGGATACCAGTCTCCACTTTGCACGCCGGAACTGCCTTGGGACC
ACAGTTACAGAAAAAATGTAAACTCAGAGTGATCCTTGTGTATATTGCTATAGATTTTTCTTTAACAAGCTATTTTAAAGATAATGGCAT
TATTATTTCCAAGCCATAGCTTGGGCTGAAGGACAAATTGAAATTGTCTGCCAATACCAAGGATATTCTTGTATATTTGAAAAATAACTT
ATTATTTGAATTGTTGTGGTTTTGTTTGTATTTGAGAGCTCTTGTTAGCTGATATTCATGTTTGAGGTCATAAAATTGTCTCTGGTCTGA
CCAAACAGAAGTCATCTTTACAGAGGTGATATGCTTGATCTACACAGAGATGTGACTTGATCTGTAGCACCAATGCAATGTAGGTCTCAG

>72374_72374_1_RASA1-RAPGEF6_RASA1_chr5_86564807_ENST00000274376_RAPGEF6_chr5_130782396_ENST00000296859_length(amino acids)=714AA_BP=180
MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGTLGGGAALGSEFLGAGSVAGALGGAGLTGGG
TAAGVAGAAAGVAGAAVAGPSGDMALTKLPTSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
SLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMS
PVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPH
KGYTLIPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHSQHGPGWTLLKPSLIKCL
AVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGS
LERKSWTSSSSLSDTYEPNYGTVKQRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPPGYLGISLA

--------------------------------------------------------------
>72374_72374_2_RASA1-RAPGEF6_RASA1_chr5_86564807_ENST00000274376_RAPGEF6_chr5_130782396_ENST00000307984_length(transcript)=5737nt_BP=1103nt
CTGAGAGCTCCAGGTAGTGAGCAGTTCAGTCGATTTCCTCGTTACCCCGCCCCCCTTTCTCTTGCCCCCCCACCCCTCTCATCTGCCTGG
TGGAGGATGAAGCGGCTGCAGTGGCCCCAGCCTCAGCAGCGGCACCGGCGGTGGCTGCGGTGTGGGTGGCCGGAACTGGGGTGGTGAAGA
AGCGGTGGTGGCGGCTGAAGGAGCGGTAGCAGCCTCAGCCTCTTTCCCTGTGCTTCCTTTCCTCTTTAGTGCAGCGAGGAAGTTTTCGCT
TCTGTACATGTGTTTGTGTGCGTGAGTGTGGGTGTGTGCGGTGAGGTTTGGGTGGCGTTTGTGCAGGCGTTGGGTTTTTTGCCCACTTGG
CTTCCCGTAACCCAGGCAGCTGGGGAGCCTGGGCTGTGGCCCTAGGAGGGGGCGCGGCGGCGGGCTCTCTCCTTTTGTTGTTGTTTCCTC
AGCCTGGGGAGCTGAAGGGGAGACGCGTCTGGGTGGGGCTGCTCGGAGCCCGGGCCTGGTGGCCCCTGGGGCTCCCGGGCGGGCAGGGTA
GGGCAGAGTAGAGCGGGCTTCAACATGATGGCGGCCGAGGCCGGCAGTGAGGAGGGCGGCCCGGTAACAGCCGGAGCTGGAGGAGGCGGC
GCGGCAGCGGGCTCCAGTGCCTATCCCGCAGTGTGTCGGGTGAAGATACCCGCGGCCCTGCCTGTGGCAGCCGCCCCCTATCCTGGGCTG
GTGGAGACCGGAGTGGCTGGAACTCTGGGTGGCGGAGCCGCTTTGGGGTCAGAGTTCCTAGGAGCCGGGTCTGTGGCAGGGGCACTGGGG
GGAGCTGGACTGACAGGGGGAGGTACTGCTGCTGGCGTAGCTGGTGCTGCTGCTGGCGTGGCCGGTGCTGCTGTTGCTGGACCTAGTGGA
GACATGGCTCTCACCAAACTGCCCACTTCGTTGCTTGCTGAGACTCTCGGGCCAGGCGGCGGTTTTCCCCCTCTGCCCCCTCCCCCTTAC
CTGCCCCCTTTGGGGGCGGGCCTCGGGACAGTGGACGAAGGTGACTCTCTGGATGGACCAGAATACGAGGAGGAAGAGGTGGCCATACCG
TTGACCGCTCCTCCAACTAACCAGTCACTGAGTCAAGGAAGCACAAATTCAAACATGCTGGATGTTCAGGGAGGTGCTCACAAAAAAAGG
GCACGCCGCAGCTCTCTGCTTAATGCCAAGAAGCTATATGAGGATGCCCAAATGGCAAGGAAGGTGAAGCAGTATCTTTCCAGTCTCGAT
GTAGAGACAGATGAGGAGAAGTTCCAGATGATGTCATTACAGTGGGAGCCTGCATATGGTACCTTGACCAAGAATTTAAGTGAGAAAAGA
TCAGCCAAATCATCTGAAATGTCTCCAGTGCCTATGAGGTCAGCTGGCCAAACAACTAAAGCCCACTTGCATCAACCCCACAGAGTAAGC
CAGGTGCTTCAGGTGCCAGCTGTTAATTTGCACCCCATCAGGAAGAAGGGACAAACAAAAGACCCTGCACTGAATACAAGTTTACCTCAG
AAAGTTTTAGGAACAACTGAAGAAATAAGTGGTAAGAAGCATACAGAAGACACTATTTCTGTGGCGTCATCTTTACATTCTAGTCCTCCT
GCATCTCCTCAAGGCTCCCCTCACAAAGGTTACACACTTATTCCATCAGCTAAATCTGACAACTTGTCTGACTCCAGCCATAGTGAGATT
TCTTCACGGTCCAGCATCGTGAGCAATTGTTCTGTTGACTCCATGTCTGCAGCTCTACAGGATGAACGGTGTTCCTCTCAGGCCCTGGCA
GTCCCTGAATCCACTGGGGCATTGGAAAAGACAGAGCACGCTTCAGGGATAGGAGATCATAGTCAACATGGCCCTGGGTGGACACTCTTG
AAGCCATCTCTAATCAAGTGTTTAGCTGTCTCATCGTCTGTGAGCAATGAAGAGATTTCTCAAGAGCATATCATTATAGAAGCAGCTGAC
AGTGGTCGTGGAAGTTGGACTTCGTGTTCAAGCAGCTCCCATGACAACTTCCAAAGCCTTCCAAACCCAAAAAGCTGGGATTTTTTGAAC
TCTTACAGACATACCCATTTGGATGACCCCATTGCTGAAGTTGAACCCACTGACTCTGAGCCCTATTCCTGTTCTAAAAGCTGCTCTAGA
ACTTGTGGGCAGTGTAAAGGAAGCCTAGAGAGAAAGAGTTGGACCTCCTCCAGTTCTCTGTCTGACACGTATGAACCAAACTATGGGACA
GTTAAACAGAGAGTATTGGAGAGCACCCCAGCTGAGTCATCTGAAGGCTTGGACCCCAAGGATGCCACTGACCCAGTTTATAAAACTGTC
ACTTCAAGTACAGAAAAGGGCTTGATTGAAAATGAACAAGTTTCAGCAGTCTAGCCTTTGGATGACCTATTTGAAAACCACTGAAAGTCG
TGGAGGAATGGGCAAGAACCACCTCATGATTCTGCAGGCCATTGCTAACGAACAGCTCATTGCTACAACCAGTCCAGAGGTTTTATTCCC
TCTACTCCGAGCAATGAAATAGACCTGAGTTATGCTTCCTTTCATTTAATTTCTGCAGATAAATAGTTTCCTGAGCAATGGATGCTATGC
CTGGATACCAGTCTCCACTTTGCACGCCGGAACTGCCTTGGGACCACAGTTACAGAAAAAATGTAAACTCAGAGTGATCCTTGTGTATAT
TGCTATAGATTTTTCTTTAACAAGCTATTTTAAAGATAATGGCATTATTATTTCCAAGCCATAGCTTGGGCTGAAGGACAAATTGAAATT
GTCTGCCAATACCAAGGATATTCTTGTATATTTGAAAAATAACTTATTATTTGAATTGTTGTGGTTTTGTTTGTATTTGAGAGCTCTTGT
TAGCTGATATTCATGTTTGAGGTCATAAAATTGTCTCTGGTCTGACCAAACAGAAGTCATCTTTACAGAGGTGATATGCTTGATCTACAC
AGAGATGTGACTTGATCTGTAGCACCAATGCAATGTAGGTCTCAGTTTGAGAGAAATAGGAAGCCCTTTGCAGTTGAGGTGTTAGGAACC
TGCTGGTCATGGTGTGGAAGGCCAAATGAAGCTGCCACAGGGTTTCTTGTCAGTCCTTTGGGAAATGGGAGGGAGTAGTTTGGGGAGGAG
GGTGGGAACCCTAATTTCCACAGAATGAAATTTTGATGTTAAATGACATGTATACAAATTCTTCCTTAAGTGAAAGTTATGCTGCATCGA
ATTGTAACTGAAAGTATAGATCCAACAAATAGAGACTGGGTTCTAGAGAGTTCTGGTCTATAGAAACCCAAAACTAAAATCTCTCATAAC
TCAAGTATGGAATACTTTTTTTAAAGAAATTCTTATCATGGGTGTTGTAATAATGAAGACGAATTTGACTTTATGCAGTGTTCTGCAGCA
TGCCTCCCCCACATCTCATAGCACCAGGTTGTGTCTGACCTGACATACCCTGCAGCTCTCAGCTGGCTGCAGTAACATTTTGTGGGAGAA
AGAGGAGCTGGAGTTACAGAAATGATTGTCTCTTGGTTCTCAGTTTTTAGCCCTTGAGAGGACATACTTTTCCAGCCTCATGGGTATGGC
ACTCTTAATTAAAATTTCAGTGACTGTTTACTGGATGAGGCAGATTTTTCACATTTTTGCAAATTAAATATATTTTATATATATTAAGTT
TAATTTTTTCAGTTTTTTTAATGTAAAAGCAAGTGAAATTTTAATAAACTTCTGTAATTACCAAAAAAAAAAAAAAAAAAAAAGCCAAAG
CCATTAACGTGCACTACCCAGATCAACTTGGAGCCAAAAGGGGTTTACTTCTGAATGGCTGTCCGTATGTGTCCACATAGGATTTAGTTG
GTTTGTGGCCTCCTTTATAGAAATGTGTTGTCTTTCCCTAGCTGTCTCTGCTGTCTGTCTTCCTGCATATCCCCCTTCATTTTAAAATCA
TGAATCAGTTGTAAGTGGTAAATGGTAGTAGTTCATCTTTCCCATCAACATGATTGTCTCTTTATTTTAGGAATAATAGCATTTCAAAAA
TTCCTGTGGTAAAGAAACATTAATCTGAAACTTAAGCCTTAGAAATTAATCGCAGGTATGATAGAATGAGGCTTGGTGGTTCCATAGCTT
TCTTGGTCCTTTGAAATGGGAAATAACCTGAACCAAAAATCCTAGTTTGAAAGTTACACTTCAGTGATTTGGCCTATAAACAGTGGTCCT
ATGATTATACATTTTTTCCTTCACTGATTTGCATAATTTTGTTTTCATGGCCACAGCAAAACAATGTGAAATATATTTTTGCTATACCCA
CTTTTTTTATCAAATTCAGATGTCTACTCTCACCATTTTATATTCATTTCCCCAGAAAAATGTGCTGTTTTCATAATGTCTTTATTTAGC
AGGTCTTTCAAACCAAATGGAAGCCTTACCTGTCTTTGTCCTTAATAGTGTAAATATCTTGCACAGAGTGTTGAGGCCTATGGTTTTGGA
CTTGCACCTTACAGCTGCCTTTGTTTTATCTATCTAGCTTTAACTGTGAGTGTTCAGATCAGCTGATCACATTGATCAGGAGCCAAAGCC
AAATGCTTTGTAGTTTGTTATGTATGTATCCCTTAAAAAATCATGAGGTTTTGATTTTTATATTTTAACTAAGGGTACATTCCTGCCTTC
TCTTAGTTTGTCATATGACTAGAACAAGAGAAGTCTTAAGCTGCATTTACTCCAATTCCAGATCTCCATTTGTTTTTGTTTTATAAATTT
ATAATCTTAATGAAGAGACTAGTGCCCTCTCTTCCTGCCACAACTCTCAATCTGCCAAGACTGTTGAAGCAGTTAACGCTCAGTGCAAAC
TTTTGCCAAATAGTAAGTTTCAACAAAATATCTTTATAGTGAAAGATTTTGAGAATTAGTAAATCCAGTACATGATTCCATAAAAGCTTA
TTAAAGTTAATAATTCTAATTTACTCCAAATGATTACTTTCAATATGATCTTTGGGGAGAAAAAGCCTTTAGTGAATTTTCTTGAGGGTG
ATAAATCACATCATTGCGATCTATATCACCTCCTTGAGAATCTCTCCCAGGCTGAAAATGTGATGGTAATCATGGGTGTTTTTAAGAACA
AATCTAATTTTTATCAAGTGTTCTTTCCTCTACAAAAAAGGAAGGAGGAGAAAAAGCTTCCTTAAAACTGATTATTTTGATTCAATTTTA
AGTTTCTAAAAAAGGTGATATTAAAGTATATGTATTCCTTCAGCATTACCTTAAAGGCTAGAAAAACGGGATAAATCTTCAGAAAAGTGT
CAAAAGTGTCACAGTACATGTTCAAATTTAAACTTGAATCCTGGTTCATCTTTGACTTTTGTTGTGCATTTTTAATGCTTCTTTATTTTT
GATACACAGAATGCAGTTGAACTTGATCTTTTAAAATTGAGACATGTAAGCTAATCAGCAAAAGACAGAAACAAAACTGCACATCTGTAA
TAATCAGATAGCAATTCTACTGCACAATTCATTGATTGTAAGGTATCCTGTAACAAGCAATGTTTGTCTCCTATTTTTTGATACCTCTTA
AACTTATGTCTTTTAGAAAGACAGTGCCTCTGTATGCTTTTTGTATTTTTACTGAGTGTAAATATTTGTTATATTTTTGGTTAAGAGAAT

>72374_72374_2_RASA1-RAPGEF6_RASA1_chr5_86564807_ENST00000274376_RAPGEF6_chr5_130782396_ENST00000307984_length(amino acids)=609AA_BP=180
MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGTLGGGAALGSEFLGAGSVAGALGGAGLTGGG
TAAGVAGAAAGVAGAAVAGPSGDMALTKLPTSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
SLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMS
PVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPH
KGYTLIPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHSQHGPGWTLLKPSLIKCL
AVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGS

--------------------------------------------------------------
>72374_72374_3_RASA1-RAPGEF6_RASA1_chr5_86564807_ENST00000274376_RAPGEF6_chr5_130782396_ENST00000308008_length(transcript)=2079nt_BP=1103nt
CTGAGAGCTCCAGGTAGTGAGCAGTTCAGTCGATTTCCTCGTTACCCCGCCCCCCTTTCTCTTGCCCCCCCACCCCTCTCATCTGCCTGG
TGGAGGATGAAGCGGCTGCAGTGGCCCCAGCCTCAGCAGCGGCACCGGCGGTGGCTGCGGTGTGGGTGGCCGGAACTGGGGTGGTGAAGA
AGCGGTGGTGGCGGCTGAAGGAGCGGTAGCAGCCTCAGCCTCTTTCCCTGTGCTTCCTTTCCTCTTTAGTGCAGCGAGGAAGTTTTCGCT
TCTGTACATGTGTTTGTGTGCGTGAGTGTGGGTGTGTGCGGTGAGGTTTGGGTGGCGTTTGTGCAGGCGTTGGGTTTTTTGCCCACTTGG
CTTCCCGTAACCCAGGCAGCTGGGGAGCCTGGGCTGTGGCCCTAGGAGGGGGCGCGGCGGCGGGCTCTCTCCTTTTGTTGTTGTTTCCTC
AGCCTGGGGAGCTGAAGGGGAGACGCGTCTGGGTGGGGCTGCTCGGAGCCCGGGCCTGGTGGCCCCTGGGGCTCCCGGGCGGGCAGGGTA
GGGCAGAGTAGAGCGGGCTTCAACATGATGGCGGCCGAGGCCGGCAGTGAGGAGGGCGGCCCGGTAACAGCCGGAGCTGGAGGAGGCGGC
GCGGCAGCGGGCTCCAGTGCCTATCCCGCAGTGTGTCGGGTGAAGATACCCGCGGCCCTGCCTGTGGCAGCCGCCCCCTATCCTGGGCTG
GTGGAGACCGGAGTGGCTGGAACTCTGGGTGGCGGAGCCGCTTTGGGGTCAGAGTTCCTAGGAGCCGGGTCTGTGGCAGGGGCACTGGGG
GGAGCTGGACTGACAGGGGGAGGTACTGCTGCTGGCGTAGCTGGTGCTGCTGCTGGCGTGGCCGGTGCTGCTGTTGCTGGACCTAGTGGA
GACATGGCTCTCACCAAACTGCCCACTTCGTTGCTTGCTGAGACTCTCGGGCCAGGCGGCGGTTTTCCCCCTCTGCCCCCTCCCCCTTAC
CTGCCCCCTTTGGGGGCGGGCCTCGGGACAGTGGACGAAGGTGACTCTCTGGATGGACCAGAATACGAGGAGGAAGAGGTGGCCATACCG
TTGACCGCTCCTCCAACTAACCAGTCACTGAGTCAAGGAAGCACAAATTCAAACATGCTGGATGTTCAGGGAGGTGCTCACAAAAAAAGG
GCACGCCGCAGCTCTCTGCTTAATGCCAAGAAGCTATATGAGGATGCCCAAATGGCAAGGAAGGTGAAGCAGTATCTTTCCAGTCTCGAT
GTAGAGACAGATGAGGAGAAGTTCCAGATGATGTCATTACAGTGGGAGCCTGCATATGGTACCTTGACCAAGAATTTAAGTGAGAAAAGA
TCAGCCAAATCATCTGAAATGTCTCCAGTGCCTATGAGGTCAGCTGGCCAAACAACTAAAGCCCACTTGCATCAACCCCACAGAGTAAGC
CAGGTGCTTCAGGTGCCAGCTGTTAATTTGCACCCCATCAGGAAGAAGGGACAAACAAAAGACCCTGCACTGAATACAAGTTTACCTCAG
AAAGTTTTAGGAACAACTGAAGAAATAAGTGGTAAGAAGCATACAGAAGACACTATTTCTGTGGCGTCATCTTTACATTCTAGTCCTCCT
GCATCTCCTCAAGGCTCCCCTCACAAAGTTGGCAGTATCATATCTGATCACAGCAGCAAGATCAGTGGCCAGAGCTGCCCCGGAATAGGT
GGGGCTTACTTGCAAAAGAAAATCCTTCAGATTACCAGGAGCACAGCCAAAAGAACAGACAGTACTGAGAAGGCCACTGAGGAGAATAGA
GACAGGACAAGTTGTGAGAACACAACCAGAAAAAGAATGACATCCCCGTTTAGAAGACTTAGGGAAAGAATGCTTTCAAGGGAGAGACTA
GTCAACAGCCAAAAAGAGGACACAGATCACAATCAAGCTACAGAAAGCTGTGAGAAAGTGAAGGATGTTGGAAGCAACATCAAAGATGAG
AAAGGGAGTGCCATCTTCAATTCAAATAGCCAAGGCAACAGTAACACTTTAAACTGCTTCTATACGCGATTCAAGTCTAAAAGGAGGAAG

>72374_72374_3_RASA1-RAPGEF6_RASA1_chr5_86564807_ENST00000274376_RAPGEF6_chr5_130782396_ENST00000308008_length(amino acids)=504AA_BP=180
MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGTLGGGAALGSEFLGAGSVAGALGGAGLTGGG
TAAGVAGAAAGVAGAAVAGPSGDMALTKLPTSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
SLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMS
PVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPH
KVGSIISDHSSKISGQSCPGIGGAYLQKKILQITRSTAKRTDSTEKATEENRDRTSCENTTRKRMTSPFRRLRERMLSRERLVNSQKEDT

--------------------------------------------------------------
>72374_72374_4_RASA1-RAPGEF6_RASA1_chr5_86564807_ENST00000274376_RAPGEF6_chr5_130782396_ENST00000507093_length(transcript)=3424nt_BP=1103nt
CTGAGAGCTCCAGGTAGTGAGCAGTTCAGTCGATTTCCTCGTTACCCCGCCCCCCTTTCTCTTGCCCCCCCACCCCTCTCATCTGCCTGG
TGGAGGATGAAGCGGCTGCAGTGGCCCCAGCCTCAGCAGCGGCACCGGCGGTGGCTGCGGTGTGGGTGGCCGGAACTGGGGTGGTGAAGA
AGCGGTGGTGGCGGCTGAAGGAGCGGTAGCAGCCTCAGCCTCTTTCCCTGTGCTTCCTTTCCTCTTTAGTGCAGCGAGGAAGTTTTCGCT
TCTGTACATGTGTTTGTGTGCGTGAGTGTGGGTGTGTGCGGTGAGGTTTGGGTGGCGTTTGTGCAGGCGTTGGGTTTTTTGCCCACTTGG
CTTCCCGTAACCCAGGCAGCTGGGGAGCCTGGGCTGTGGCCCTAGGAGGGGGCGCGGCGGCGGGCTCTCTCCTTTTGTTGTTGTTTCCTC
AGCCTGGGGAGCTGAAGGGGAGACGCGTCTGGGTGGGGCTGCTCGGAGCCCGGGCCTGGTGGCCCCTGGGGCTCCCGGGCGGGCAGGGTA
GGGCAGAGTAGAGCGGGCTTCAACATGATGGCGGCCGAGGCCGGCAGTGAGGAGGGCGGCCCGGTAACAGCCGGAGCTGGAGGAGGCGGC
GCGGCAGCGGGCTCCAGTGCCTATCCCGCAGTGTGTCGGGTGAAGATACCCGCGGCCCTGCCTGTGGCAGCCGCCCCCTATCCTGGGCTG
GTGGAGACCGGAGTGGCTGGAACTCTGGGTGGCGGAGCCGCTTTGGGGTCAGAGTTCCTAGGAGCCGGGTCTGTGGCAGGGGCACTGGGG
GGAGCTGGACTGACAGGGGGAGGTACTGCTGCTGGCGTAGCTGGTGCTGCTGCTGGCGTGGCCGGTGCTGCTGTTGCTGGACCTAGTGGA
GACATGGCTCTCACCAAACTGCCCACTTCGTTGCTTGCTGAGACTCTCGGGCCAGGCGGCGGTTTTCCCCCTCTGCCCCCTCCCCCTTAC
CTGCCCCCTTTGGGGGCGGGCCTCGGGACAGTGGACGAAGGTGACTCTCTGGATGGACCAGAATACGAGGAGGAAGAGGTGGCCATACCG
TTGACCGCTCCTCCAACTAACCAGTCACTGAGTCAAGGAAGCACAAATTCAAACATGCTGGATGTTCAGGGAGGTGCTCACAAAAAAAGG
GCACGCCGCAGCTCTCTGCTTAATGCCAAGAAGCTATATGAGGATGCCCAAATGGCAAGGAAGGTGAAGCAGTATCTTTCCAGTCTCGAT
GTAGAGACAGATGAGGAGAAGTTCCAGATGATGTCATTACAGTGGGAGCCTGCATATGGTACCTTGACCAAGAATTTAAGTGAGAAAAGA
TCAGCCAAATCATCTGAAATGTCTCCAGTGCCTATGAGGTCAGCTGGCCAAACAACTAAAGCCCACTTGCATCAACCCCACAGAGTAAGC
CAGGTGCTTCAGGTGCCAGCTGTTAATTTGCACCCCATCAGGAAGAAGGGACAAACAAAAGACCCTGCACTGAATACAAGTTTACCTCAG
AAAGTTTTAGGAACAACTGAAGAAATAAGTGGTAAGAAGCATACAGAAGACACTATTTCTGTGGCGTCATCTTTACATTCTAGTCCTCCT
GCATCTCCTCAAGGCTCCCCTCACAAAGGTTACACACTTATTCCATCAGCTAAATCTGACAACTTGTCTGACTCCAGCCATAGTGAGATT
TCTTCACGGTCCAGCATCGTGAGCAATTGTTCTGTTGACTCCATGTCTGCAGCTCTACAGGATGAACGGTGTTCCTCTCAGGCCCTGGCA
GTCCCTGAATCCACTGGGGCATTGGAAAAGACAGAGCACGCTTCAGGGATAGGAGATCATAGTCAACATGGCCCTGGGTGGACACTCTTG
AAGCCATCTCTAATCAAGTGTTTAGCTGTCTCATCGTCTGTGAGCAATGAAGAGATTTCTCAAGAGCATATCATTATAGAAGCAGCTGAC
AGTGGTCGTGGAAGTTGGACTTCGTGTTCAAGCAGCTCCCATGACAACTTCCAAAGCCTTCCAAACCCAAAAAGCTGGGATTTTTTGAAC
TCTTACAGACATACCCATTTGGATGACCCCATTGCTGAAGTTGAACCCACTGACTCTGAGCCCTATTCCTGTTCTAAAAGCTGCTCTAGA
ACTTGTGGGCAGTGTAAAGGAAGCCTAGAGAGAAAGAGTTGGACCTCCTCCAGTTCTCTGTCTGACACGTATGAACCAAACTATGGGACA
GTTAAACAGAGAGTATTGGAGAGCACCCCAGCTGAGTCATCTGAAGGCTTGGACCCCAAGGATGCCACTGACCCAGTTTATAAAACTGTC
ACTTCAAGTACAGAAAAGGGCTTGATTGAAAATGAACAAGTTTCAGCAGTCTAGCCTTTGGATGACCTATTTGAAAACCACTGAAAGTCG
TGGAGGAATGGGCAAGAACCACCTCATGATTCTGCAGGCCATTGCTAACGAACAGCTCATTGCTACAACCAGTCCAGAGGTTTTATTCCC
TCTACTCCGAGCAATGAAATAGACCTGAGTTATGCTTCCTTTCATTTAATTTCTGCAGATAAATAGTTTCCTGAGCAATGGATGCTATGC
CTGGATACCAGTCTCCACTTTGCACGCCGGAACTGCCTTGGGACCACAGTTACAGAAAAAATGTAAACTCAGAGTGATCCTTGTGTATAT
TGCTATAGATTTTTCTTTAACAAGCTATTTTAAAGATAATGGCATTATTATTTCCAAGCCATAGCTTGGGCTGAAGGACAAATTGAAATT
GTCTGCCAATACCAAGGATATTCTTGTATATTTGAAAAATAACTTATTATTTGAATTGTTGTGGTTTTGTTTGTATTTGAGAGCTCTTGT
TAGCTGATATTCATGTTTGAGGTCATAAAATTGTCTCTGGTCTGACCAAACAGAAGTCATCTTTACAGAGGTGATATGCTTGATCTACAC
AGAGATGTGACTTGATCTGTAGCACCAATGCAATGTAGGTCTCAGTTTGAGAGAAATAGGAAGCCCTTTGCAGTTGAGGTGTTAGGAACC
TGCTGGTCATGGTGTGGAAGGCCAAATGAAGCTGCCACAGGGTTTCTTGTCAGTCCTTTGGGAAATGGGAGGGAGTAGTTTGGGGAGGAG
GGTGGGAACCCTAATTTCCACAGAATGAAATTTTGATGTTAAATGACATGTATACAAATTCTTCCTTAAGTGAAAGTTATGCTGCATCGA
ATTGTAACTGAAAGTATAGATCCAACAAATAGAGACTGGGTTCTAGAGAGTTCTGGTCTATAGAAACCCAAAACTAAAATCTCTCATAAC
TCAAGTATGGAATACTTTTTTTAAAGAAATTCTTATCATGGGTGTTGTAATAATGAAGACGAATTTGACTTTATGCAGTGTTCTGCAGCA

>72374_72374_4_RASA1-RAPGEF6_RASA1_chr5_86564807_ENST00000274376_RAPGEF6_chr5_130782396_ENST00000507093_length(amino acids)=609AA_BP=180
MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGTLGGGAALGSEFLGAGSVAGALGGAGLTGGG
TAAGVAGAAAGVAGAAVAGPSGDMALTKLPTSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
SLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMS
PVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPH
KGYTLIPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHSQHGPGWTLLKPSLIKCL
AVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGS

--------------------------------------------------------------
>72374_72374_5_RASA1-RAPGEF6_RASA1_chr5_86564807_ENST00000274376_RAPGEF6_chr5_130782396_ENST00000509018_length(transcript)=6054nt_BP=1103nt
CTGAGAGCTCCAGGTAGTGAGCAGTTCAGTCGATTTCCTCGTTACCCCGCCCCCCTTTCTCTTGCCCCCCCACCCCTCTCATCTGCCTGG
TGGAGGATGAAGCGGCTGCAGTGGCCCCAGCCTCAGCAGCGGCACCGGCGGTGGCTGCGGTGTGGGTGGCCGGAACTGGGGTGGTGAAGA
AGCGGTGGTGGCGGCTGAAGGAGCGGTAGCAGCCTCAGCCTCTTTCCCTGTGCTTCCTTTCCTCTTTAGTGCAGCGAGGAAGTTTTCGCT
TCTGTACATGTGTTTGTGTGCGTGAGTGTGGGTGTGTGCGGTGAGGTTTGGGTGGCGTTTGTGCAGGCGTTGGGTTTTTTGCCCACTTGG
CTTCCCGTAACCCAGGCAGCTGGGGAGCCTGGGCTGTGGCCCTAGGAGGGGGCGCGGCGGCGGGCTCTCTCCTTTTGTTGTTGTTTCCTC
AGCCTGGGGAGCTGAAGGGGAGACGCGTCTGGGTGGGGCTGCTCGGAGCCCGGGCCTGGTGGCCCCTGGGGCTCCCGGGCGGGCAGGGTA
GGGCAGAGTAGAGCGGGCTTCAACATGATGGCGGCCGAGGCCGGCAGTGAGGAGGGCGGCCCGGTAACAGCCGGAGCTGGAGGAGGCGGC
GCGGCAGCGGGCTCCAGTGCCTATCCCGCAGTGTGTCGGGTGAAGATACCCGCGGCCCTGCCTGTGGCAGCCGCCCCCTATCCTGGGCTG
GTGGAGACCGGAGTGGCTGGAACTCTGGGTGGCGGAGCCGCTTTGGGGTCAGAGTTCCTAGGAGCCGGGTCTGTGGCAGGGGCACTGGGG
GGAGCTGGACTGACAGGGGGAGGTACTGCTGCTGGCGTAGCTGGTGCTGCTGCTGGCGTGGCCGGTGCTGCTGTTGCTGGACCTAGTGGA
GACATGGCTCTCACCAAACTGCCCACTTCGTTGCTTGCTGAGACTCTCGGGCCAGGCGGCGGTTTTCCCCCTCTGCCCCCTCCCCCTTAC
CTGCCCCCTTTGGGGGCGGGCCTCGGGACAGTGGACGAAGGTGACTCTCTGGATGGACCAGAATACGAGGAGGAAGAGGTGGCCATACCG
TTGACCGCTCCTCCAACTAACCAGTCACTGAGTCAAGGAAGCACAAATTCAAACATGCTGGATGTTCAGGGAGGTGCTCACAAAAAAAGG
GCACGCCGCAGCTCTCTGCTTAATGCCAAGAAGCTATATGAGGATGCCCAAATGGCAAGGAAGGTGAAGCAGTATCTTTCCAGTCTCGAT
GTAGAGACAGATGAGGAGAAGTTCCAGATGATGTCATTACAGTGGGAGCCTGCATATGGTACCTTGACCAAGAATTTAAGTGAGAAAAGA
TCAGCCAAATCATCTGAAATGTCTCCAGTGCCTATGAGGTCAGCTGGCCAAACAACTAAAGCCCACTTGCATCAACCCCACAGAGTAAGC
CAGGTGCTTCAGGTGCCAGCTGTTAATTTGCACCCCATCAGGAAGAAGGGACAAACAAAAGACCCTGCACTGAATACAAGTTTACCTCAG
AAAGTTTTAGGAACAACTGAAGAAATAAGTGGTAAGAAGCATACAGAAGACACTATTTCTGTGGCGTCATCTTTACATTCTAGTCCTCCT
GCATCTCCTCAAGGCTCCCCTCACAAAGGTTACACACTTATTCCATCAGCTAAATCTGACAACTTGTCTGACTCCAGCCATAGTGAGATT
TCTTCACGGTCCAGCATCGTGAGCAATTGTTCTGTTGACTCCATGTCTGCAGCTCTACAGGATGAACGGTGTTCCTCTCAGGCCCTGGCA
GTCCCTGAATCCACTGGGGCATTGGAAAAGACAGAGCACGCTTCAGGGATAGGAGATCATAGTCAACATGGCCCTGGGTGGACACTCTTG
AAGCCATCTCTAATCAAGTGTTTAGCTGTCTCATCGTCTGTGAGCAATGAAGAGATTTCTCAAGAGCATATCATTATAGAAGCAGCTGAC
AGTGGTCGTGGAAGTTGGACTTCGTGTTCAAGCAGCTCCCATGACAACTTCCAAAGCCTTCCAAACCCAAAAAGCTGGGATTTTTTGAAC
TCTTACAGACATACCCATTTGGATGACCCCATTGCTGAAGTTGAACCCACTGACTCTGAGCCCTATTCCTGTTCTAAAAGCTGCTCTAGA
ACTTGTGGGCAGTGTAAAGGAAGCCTAGAGAGAAAGAGTTGGACCTCCTCCAGTTCTCTGTCTGACACGTATGAACCAAACTATGGGACA
GTTAAACAGAGAGTATTGGAGAGCACCCCAGCTGAGTCATCTGAAGGCTTGGACCCCAAGGATGCCACTGACCCAGTTTATAAAACTGTC
ACTTCAAGTACAGAAAAGGGCTTGATTGTGTACTGTGTCACCTCACCCAAGAAGGACGATAGGTATAGGGAGCCACCTCCCACTCCTCCA
GGATATTTGGGGATTTCTTTAGCGGACCTAAAGGAAGGACCCCACACACACCTAAAACCTCCAGATTATAGTGTGGCAGTGCAGAGGTCA
AAGATGATGCATAACAGCCTCTCTAGACTGCCACCAGCTTCTCTCAGTAGCAACCTCGTGGCCTGTGTTCCATCGAAGATTGTAACTCAG
CCTCAGAGGCATAATTTGCAGCCATTCCATCCTAAACTAGGAGATGTGACTGATGCAGATAGCGAAGCAGATGAAAATGAACAAGTTTCA
GCAGTCTAGCCTTTGGATGACCTATTTGAAAACCACTGAAAGTCGTGGAGGAATGGGCAAGAACCACCTCATGATTCTGCAGGCCATTGC
TAACGAACAGCTCATTGCTACAACCAGTCCAGAGGTTTTATTCCCTCTACTCCGAGCAATGAAATAGACCTGAGTTATGCTTCCTTTCAT
TTAATTTCTGCAGATAAATAGTTTCCTGAGCAATGGATGCTATGCCTGGATACCAGTCTCCACTTTGCACGCCGGAACTGCCTTGGGACC
ACAGTTACAGAAAAAATGTAAACTCAGAGTGATCCTTGTGTATATTGCTATAGATTTTTCTTTAACAAGCTATTTTAAAGATAATGGCAT
TATTATTTCCAAGCCATAGCTTGGGCTGAAGGACAAATTGAAATTGTCTGCCAATACCAAGGATATTCTTGTATATTTGAAAAATAACTT
ATTATTTGAATTGTTGTGGTTTTGTTTGTATTTGAGAGCTCTTGTTAGCTGATATTCATGTTTGAGGTCATAAAATTGTCTCTGGTCTGA
CCAAACAGAAGTCATCTTTACAGAGGTGATATGCTTGATCTACACAGAGATGTGACTTGATCTGTAGCACCAATGCAATGTAGGTCTCAG
TTTGAGAGAAATAGGAAGCCCTTTGCAGTTGAGGTGTTAGGAACCTGCTGGTCATGGTGTGGAAGGCCAAATGAAGCTGCCACAGGGTTT
CTTGTCAGTCCTTTGGGAAATGGGAGGGAGTAGTTTGGGGAGGAGGGTGGGAACCCTAATTTCCACAGAATGAAATTTTGATGTTAAATG
ACATGTATACAAATTCTTCCTTAAGTGAAAGTTATGCTGCATCGAATTGTAACTGAAAGTATAGATCCAACAAATAGAGACTGGGTTCTA
GAGAGTTCTGGTCTATAGAAACCCAAAACTAAAATCTCTCATAACTCAAGTATGGAATACTTTTTTTAAAGAAATTCTTATCATGGGTGT
TGTAATAATGAAGACGAATTTGACTTTATGCAGTGTTCTGCAGCATGCCTCCCCCACATCTCATAGCACCAGGTTGTGTCTGACCTGACA
TACCCTGCAGCTCTCAGCTGGCTGCAGTAACATTTTGTGGGAGAAAGAGGAGCTGGAGTTACAGAAATGATTGTCTCTTGGTTCTCAGTT
TTTAGCCCTTGAGAGGACATACTTTTCCAGCCTCATGGGTATGGCACTCTTAATTAAAATTTCAGTGACTGTTTACTGGATGAGGCAGAT
TTTTCACATTTTTGCAAATTAAATATATTTTATATATATTAAGTTTAATTTTTTCAGTTTTTTTAATGTAAAAGCAAGTGAAATTTTAAT
AAACTTCTGTAATTACCAAAAAAAAAAAAAAAAAAAAAGCCAAAGCCATTAACGTGCACTACCCAGATCAACTTGGAGCCAAAAGGGGTT
TACTTCTGAATGGCTGTCCGTATGTGTCCACATAGGATTTAGTTGGTTTGTGGCCTCCTTTATAGAAATGTGTTGTCTTTCCCTAGCTGT
CTCTGCTGTCTGTCTTCCTGCATATCCCCCTTCATTTTAAAATCATGAATCAGTTGTAAGTGGTAAATGGTAGTAGTTCATCTTTCCCAT
CAACATGATTGTCTCTTTATTTTAGGAATAATAGCATTTCAAAAATTCCTGTGGTAAAGAAACATTAATCTGAAACTTAAGCCTTAGAAA
TTAATCGCAGGTATGATAGAATGAGGCTTGGTGGTTCCATAGCTTTCTTGGTCCTTTGAAATGGGAAATAACCTGAACCAAAAATCCTAG
TTTGAAAGTTACACTTCAGTGATTTGGCCTATAAACAGTGGTCCTATGATTATACATTTTTTCCTTCACTGATTTGCATAATTTTGTTTT
CATGGCCACAGCAAAACAATGTGAAATATATTTTTGCTATACCCACTTTTTTTATCAAATTCAGATGTCTACTCTCACCATTTTATATTC
ATTTCCCCAGAAAAATGTGCTGTTTTCATAATGTCTTTATTTAGCAGGTCTTTCAAACCAAATGGAAGCCTTACCTGTCTTTGTCCTTAA
TAGTGTAAATATCTTGCACAGAGTGTTGAGGCCTATGGTTTTGGACTTGCACCTTACAGCTGCCTTTGTTTTATCTATCTAGCTTTAACT
GTGAGTGTTCAGATCAGCTGATCACATTGATCAGGAGCCAAAGCCAAATGCTTTGTAGTTTGTTATGTATGTATCCCTTAAAAAATCATG
AGGTTTTGATTTTTATATTTTAACTAAGGGTACATTCCTGCCTTCTCTTAGTTTGTCATATGACTAGAACAAGAGAAGTCTTAAGCTGCA
TTTACTCCAATTCCAGATCTCCATTTGTTTTTGTTTTATAAATTTATAATCTTAATGAAGAGACTAGTGCCCTCTCTTCCTGCCACAACT
CTCAATCTGCCAAGACTGTTGAAGCAGTTAACGCTCAGTGCAAACTTTTGCCAAATAGTAAGTTTCAACAAAATATCTTTATAGTGAAAG
ATTTTGAGAATTAGTAAATCCAGTACATGATTCCATAAAAGCTTATTAAAGTTAATAATTCTAATTTACTCCAAATGATTACTTTCAATA
TGATCTTTGGGGAGAAAAAGCCTTTAGTGAATTTTCTTGAGGGTGATAAATCACATCATTGCGATCTATATCACCTCCTTGAGAATCTCT
CCCAGGCTGAAAATGTGATGGTAATCATGGGTGTTTTTAAGAACAAATCTAATTTTTATCAAGTGTTCTTTCCTCTACAAAAAAGGAAGG
AGGAGAAAAAGCTTCCTTAAAACTGATTATTTTGATTCAATTTTAAGTTTCTAAAAAAGGTGATATTAAAGTATATGTATTCCTTCAGCA
TTACCTTAAAGGCTAGAAAAACGGGATAAATCTTCAGAAAAGTGTCAAAAGTGTCACAGTACATGTTCAAATTTAAACTTGAATCCTGGT
TCATCTTTGACTTTTGTTGTGCATTTTTAATGCTTCTTTATTTTTGATACACAGAATGCAGTTGAACTTGATCTTTTAAAATTGAGACAT
GTAAGCTAATCAGCAAAAGACAGAAACAAAACTGCACATCTGTAATAATCAGATAGCAATTCTACTGCACAATTCATTGATTGTAAGGTA
TCCTGTAACAAGCAATGTTTGTCTCCTATTTTTTGATACCTCTTAAACTTATGTCTTTTAGAAAGACAGTGCCTCTGTATGCTTTTTGTA
TTTTTACTGAGTGTAAATATTTGTTATATTTTTGGTTAAGAGAATGTAAAAATACCATTTATTATTATCATATCTACTAATACATTGGTG

>72374_72374_5_RASA1-RAPGEF6_RASA1_chr5_86564807_ENST00000274376_RAPGEF6_chr5_130782396_ENST00000509018_length(amino acids)=714AA_BP=180
MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGTLGGGAALGSEFLGAGSVAGALGGAGLTGGG
TAAGVAGAAAGVAGAAVAGPSGDMALTKLPTSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
SLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMS
PVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPH
KGYTLIPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHSQHGPGWTLLKPSLIKCL
AVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGS
LERKSWTSSSSLSDTYEPNYGTVKQRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPPGYLGISLA

--------------------------------------------------------------
>72374_72374_6_RASA1-RAPGEF6_RASA1_chr5_86564807_ENST00000274376_RAPGEF6_chr5_130782396_ENST00000512052_length(transcript)=2269nt_BP=1103nt
CTGAGAGCTCCAGGTAGTGAGCAGTTCAGTCGATTTCCTCGTTACCCCGCCCCCCTTTCTCTTGCCCCCCCACCCCTCTCATCTGCCTGG
TGGAGGATGAAGCGGCTGCAGTGGCCCCAGCCTCAGCAGCGGCACCGGCGGTGGCTGCGGTGTGGGTGGCCGGAACTGGGGTGGTGAAGA
AGCGGTGGTGGCGGCTGAAGGAGCGGTAGCAGCCTCAGCCTCTTTCCCTGTGCTTCCTTTCCTCTTTAGTGCAGCGAGGAAGTTTTCGCT
TCTGTACATGTGTTTGTGTGCGTGAGTGTGGGTGTGTGCGGTGAGGTTTGGGTGGCGTTTGTGCAGGCGTTGGGTTTTTTGCCCACTTGG
CTTCCCGTAACCCAGGCAGCTGGGGAGCCTGGGCTGTGGCCCTAGGAGGGGGCGCGGCGGCGGGCTCTCTCCTTTTGTTGTTGTTTCCTC
AGCCTGGGGAGCTGAAGGGGAGACGCGTCTGGGTGGGGCTGCTCGGAGCCCGGGCCTGGTGGCCCCTGGGGCTCCCGGGCGGGCAGGGTA
GGGCAGAGTAGAGCGGGCTTCAACATGATGGCGGCCGAGGCCGGCAGTGAGGAGGGCGGCCCGGTAACAGCCGGAGCTGGAGGAGGCGGC
GCGGCAGCGGGCTCCAGTGCCTATCCCGCAGTGTGTCGGGTGAAGATACCCGCGGCCCTGCCTGTGGCAGCCGCCCCCTATCCTGGGCTG
GTGGAGACCGGAGTGGCTGGAACTCTGGGTGGCGGAGCCGCTTTGGGGTCAGAGTTCCTAGGAGCCGGGTCTGTGGCAGGGGCACTGGGG
GGAGCTGGACTGACAGGGGGAGGTACTGCTGCTGGCGTAGCTGGTGCTGCTGCTGGCGTGGCCGGTGCTGCTGTTGCTGGACCTAGTGGA
GACATGGCTCTCACCAAACTGCCCACTTCGTTGCTTGCTGAGACTCTCGGGCCAGGCGGCGGTTTTCCCCCTCTGCCCCCTCCCCCTTAC
CTGCCCCCTTTGGGGGCGGGCCTCGGGACAGTGGACGAAGGTGACTCTCTGGATGGACCAGAATACGAGGAGGAAGAGGTGGCCATACCG
TTGACCGCTCCTCCAACTAACCAGTCACTGAGTCAAGGAAGCACAAATTCAAACATGCTGGATGTTCAGGGAGGTGCTCACAAAAAAAGG
GCACGCCGCAGCTCTCTGCTTAATGCCAAGAAGCTATATGAGGATGCCCAAATGGCAAGGAAGGTGAAGCAGTATCTTTCCAGTCTCGAT
GTAGAGACAGATGAGGAGAAGTTCCAGATGATGTCATTACAGTGGGAGCCTGCATATGGTACCTTGACCAAGAATTTAAGTGAGAAAAGA
TCAGCCAAATCATCTGAAATGTCTCCAGTGCCTATGAGGTCAGCTGGCCAAACAACTAAAGCCCACTTGCATCAACCCCACAGAGTAAGC
CAGGTGCTTCAGGTGCCAGCTGTTAATTTGCACCCCATCAGGAAGAAGGGACAAACAAAAGACCCTGCACTGAATACAAGTTTACCTCAG
AAAGTTTTAGGAACAACTGAAGAAATAAGTGGTAAGAAGCATACAGAAGACACTATTTCTGTGGCGTCATCTTTACATTCTAGTCCTCCT
GCATCTCCTCAAGGCTCCCCTCACAAAGTTGGCAGTATCATATCTGATCACAGCAGCAAGATCAGTGGCCAGAGCTGCCCCGGAATAGGT
GGGGCTTACTTGCAAAAGAAAATCCTTCAGATTACCAGGAGCACAGCCAAAAGAACAGACAGTACTGAGAAGGCCACTGAGGAGAATAGA
GACAGGACAAGTTGTGAGAACACAACCAGAAAAAGAATGACATCCCCGTTTAGAAGACTTAGGGAAAGAATGCTTTCAAGGGAGAGACTA
GTCAACAGCCAAAAAGAGGACACAGATCACAATCAAGCTACAGAAAGCTGTGAGAAAGTGAAGGATGTTGGAAGCAACATCAAAGATGAG
AAAGGGAGTGCCATCTTCAATTCAAATAGCCAAGGCAACAGTAACACTTTAAACTGCTTCTATACGCGATTCAAGTCTAAAAGGAGGAAG
ACACTCTGATGAAGTTCCTTATTTAATTTTAGTGTTAAGTTTGTTTTCAGTTATTAATGTATACATGGCTTAAATTAAACCATTTGTCAA
AGCTTAGGCAGACAACTTAGTAAAATACTATTTATAAACACTTGAAAATGCCTCATTTGTACATAAGTTATTTTACTGATGTATTGAGTT

>72374_72374_6_RASA1-RAPGEF6_RASA1_chr5_86564807_ENST00000274376_RAPGEF6_chr5_130782396_ENST00000512052_length(amino acids)=504AA_BP=180
MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGTLGGGAALGSEFLGAGSVAGALGGAGLTGGG
TAAGVAGAAAGVAGAAVAGPSGDMALTKLPTSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
SLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMS
PVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPH
KVGSIISDHSSKISGQSCPGIGGAYLQKKILQITRSTAKRTDSTEKATEENRDRTSCENTTRKRMTSPFRRLRERMLSRERLVNSQKEDT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RASA1-RAPGEF6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RASA1-RAPGEF6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RASA1-RAPGEF6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource