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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RASA1-XRCC4 (FusionGDB2 ID:72378)

Fusion Gene Summary for RASA1-XRCC4

check button Fusion gene summary
Fusion gene informationFusion gene name: RASA1-XRCC4
Fusion gene ID: 72378
HgeneTgene
Gene symbol

RASA1

XRCC4

Gene ID

8831

7518

Gene namesynaptic Ras GTPase activating protein 1X-ray repair cross complementing 4
SynonymsMRD5|RASA1|RASA5|SYNGAPSSMED
Cytomap

6p21.32

5q14.2

Type of geneprotein-codingprotein-coding
Descriptionras/Rap GTPase-activating protein SynGAPRas GTPase-activating protein SynGAPneuronal RasGAPsynaptic Ras GTPase activating protein 1 homologsynaptic Ras GTPase activating protein, 135kDaDNA repair protein XRCC4X-ray repair complementing defective repair in Chinese hamster cells 4
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000274376, ENST00000456692, 
ENST00000506290, ENST00000512763, 
ENST00000509268, ENST00000282268, 
ENST00000511817, ENST00000338635, 
ENST00000396027, 
Fusion gene scores* DoF score9 X 7 X 6=3789 X 8 X 4=288
# samples 99
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RASA1 [Title/Abstract] AND XRCC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRASA1(86645181)-XRCC4(82648944), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneXRCC4

GO:0006302

double-strand break repair

9242410

TgeneXRCC4

GO:0006303

double-strand break repair via nonhomologous end joining

12517771

TgeneXRCC4

GO:0010165

response to X-ray

9242410

TgeneXRCC4

GO:0051103

DNA ligation involved in DNA repair

12517771

TgeneXRCC4

GO:0051351

positive regulation of ligase activity

9242410


check buttonFusion gene breakpoints across RASA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across XRCC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-K1-A6RV-01ARASA1chr5

86645181

-XRCC4chr5

82648944

+
ChimerDB4SARCTCGA-K1-A6RV-01ARASA1chr5

86645181

+XRCC4chr5

82648944

+


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Fusion Gene ORF analysis for RASA1-XRCC4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000274376ENST00000509268RASA1chr5

86645181

+XRCC4chr5

82648944

+
5CDS-intronENST00000456692ENST00000509268RASA1chr5

86645181

+XRCC4chr5

82648944

+
5CDS-intronENST00000506290ENST00000509268RASA1chr5

86645181

+XRCC4chr5

82648944

+
5CDS-intronENST00000512763ENST00000509268RASA1chr5

86645181

+XRCC4chr5

82648944

+
Frame-shiftENST00000274376ENST00000282268RASA1chr5

86645181

+XRCC4chr5

82648944

+
Frame-shiftENST00000274376ENST00000511817RASA1chr5

86645181

+XRCC4chr5

82648944

+
Frame-shiftENST00000456692ENST00000282268RASA1chr5

86645181

+XRCC4chr5

82648944

+
Frame-shiftENST00000456692ENST00000511817RASA1chr5

86645181

+XRCC4chr5

82648944

+
Frame-shiftENST00000506290ENST00000282268RASA1chr5

86645181

+XRCC4chr5

82648944

+
Frame-shiftENST00000506290ENST00000511817RASA1chr5

86645181

+XRCC4chr5

82648944

+
Frame-shiftENST00000512763ENST00000282268RASA1chr5

86645181

+XRCC4chr5

82648944

+
Frame-shiftENST00000512763ENST00000511817RASA1chr5

86645181

+XRCC4chr5

82648944

+
In-frameENST00000274376ENST00000338635RASA1chr5

86645181

+XRCC4chr5

82648944

+
In-frameENST00000274376ENST00000396027RASA1chr5

86645181

+XRCC4chr5

82648944

+
In-frameENST00000456692ENST00000338635RASA1chr5

86645181

+XRCC4chr5

82648944

+
In-frameENST00000456692ENST00000396027RASA1chr5

86645181

+XRCC4chr5

82648944

+
In-frameENST00000506290ENST00000338635RASA1chr5

86645181

+XRCC4chr5

82648944

+
In-frameENST00000506290ENST00000396027RASA1chr5

86645181

+XRCC4chr5

82648944

+
In-frameENST00000512763ENST00000338635RASA1chr5

86645181

+XRCC4chr5

82648944

+
In-frameENST00000512763ENST00000396027RASA1chr5

86645181

+XRCC4chr5

82648944

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000274376RASA1chr586645181+ENST00000338635XRCC4chr582648944+240418175641934456
ENST00000274376RASA1chr586645181+ENST00000396027XRCC4chr582648944+239818175641928454
ENST00000456692RASA1chr586645181+ENST00000338635XRCC4chr582648944+1424837115954279
ENST00000456692RASA1chr586645181+ENST00000396027XRCC4chr582648944+1418837115948277
ENST00000512763RASA1chr586645181+ENST00000338635XRCC4chr582648944+15409532011070289
ENST00000512763RASA1chr586645181+ENST00000396027XRCC4chr582648944+15349532011064287
ENST00000506290RASA1chr586645181+ENST00000338635XRCC4chr582648944+1459872117989290
ENST00000506290RASA1chr586645181+ENST00000396027XRCC4chr582648944+1453872117983288

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000274376ENST00000338635RASA1chr586645181+XRCC4chr582648944+0.0003540770.99964595
ENST00000274376ENST00000396027RASA1chr586645181+XRCC4chr582648944+0.0003542880.9996457
ENST00000456692ENST00000338635RASA1chr586645181+XRCC4chr582648944+0.0009974470.9990025
ENST00000456692ENST00000396027RASA1chr586645181+XRCC4chr582648944+0.0009994740.9990005
ENST00000512763ENST00000338635RASA1chr586645181+XRCC4chr582648944+0.0002544870.99974555
ENST00000512763ENST00000396027RASA1chr586645181+XRCC4chr582648944+0.0003280930.99967194
ENST00000506290ENST00000338635RASA1chr586645181+XRCC4chr582648944+0.0002635610.9997365
ENST00000506290ENST00000396027RASA1chr586645181+XRCC4chr582648944+0.000253040.999747

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Fusion Genomic Features for RASA1-XRCC4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RASA1chr586645181+XRCC4chr582648943+0.0012556270.99874437
RASA1chr586645181+XRCC4chr582648943+0.0012556270.99874437

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RASA1-XRCC4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:86645181/chr5:82648944)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRASA1chr5:86645181chr5:82648944ENST00000274376+825135_1414171048.0Compositional biasNote=Poly-Pro
HgeneRASA1chr5:86645181chr5:82648944ENST00000274376+825163_1684171048.0Compositional biasNote=Poly-Glu
HgeneRASA1chr5:86645181chr5:82648944ENST00000274376+82517_224171048.0Compositional biasNote=Poly-Gly
HgeneRASA1chr5:86645181chr5:82648944ENST00000456692+825135_141240871.0Compositional biasNote=Poly-Pro
HgeneRASA1chr5:86645181chr5:82648944ENST00000456692+825163_168240871.0Compositional biasNote=Poly-Glu
HgeneRASA1chr5:86645181chr5:82648944ENST00000456692+82517_22240871.0Compositional biasNote=Poly-Gly
HgeneRASA1chr5:86645181chr5:82648944ENST00000274376+825181_2724171048.0DomainSH2 1
HgeneRASA1chr5:86645181chr5:82648944ENST00000274376+825279_3414171048.0DomainSH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRASA1chr5:86645181chr5:82648944ENST00000274376+825351_4414171048.0DomainSH2 2
HgeneRASA1chr5:86645181chr5:82648944ENST00000274376+825474_5774171048.0DomainPH
HgeneRASA1chr5:86645181chr5:82648944ENST00000274376+825577_6904171048.0DomainC2
HgeneRASA1chr5:86645181chr5:82648944ENST00000274376+825748_9424171048.0DomainRas-GAP
HgeneRASA1chr5:86645181chr5:82648944ENST00000456692+825181_272240871.0DomainSH2 1
HgeneRASA1chr5:86645181chr5:82648944ENST00000456692+825279_341240871.0DomainSH3
HgeneRASA1chr5:86645181chr5:82648944ENST00000456692+825351_441240871.0DomainSH2 2
HgeneRASA1chr5:86645181chr5:82648944ENST00000456692+825474_577240871.0DomainPH
HgeneRASA1chr5:86645181chr5:82648944ENST00000456692+825577_690240871.0DomainC2
HgeneRASA1chr5:86645181chr5:82648944ENST00000456692+825748_942240871.0DomainRas-GAP
TgeneXRCC4chr5:86645181chr5:82648944ENST0000028226868131_165297335.0Coiled coilOntology_term=ECO:0000255
TgeneXRCC4chr5:86645181chr5:82648944ENST0000028226868184_212297335.0Coiled coilOntology_term=ECO:0000255
TgeneXRCC4chr5:86645181chr5:82648944ENST0000033863568131_165297337.0Coiled coilOntology_term=ECO:0000255
TgeneXRCC4chr5:86645181chr5:82648944ENST0000033863568184_212297337.0Coiled coilOntology_term=ECO:0000255
TgeneXRCC4chr5:86645181chr5:82648944ENST0000039602768131_165297335.0Coiled coilOntology_term=ECO:0000255
TgeneXRCC4chr5:86645181chr5:82648944ENST0000039602768184_212297335.0Coiled coilOntology_term=ECO:0000255
TgeneXRCC4chr5:86645181chr5:82648944ENST0000051181768131_165297337.0Coiled coilOntology_term=ECO:0000255
TgeneXRCC4chr5:86645181chr5:82648944ENST0000051181768184_212297337.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for RASA1-XRCC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72378_72378_1_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000274376_XRCC4_chr5_82648944_ENST00000338635_length(transcript)=2404nt_BP=1817nt
CTGAGAGCTCCAGGTAGTGAGCAGTTCAGTCGATTTCCTCGTTACCCCGCCCCCCTTTCTCTTGCCCCCCCACCCCTCTCATCTGCCTGG
TGGAGGATGAAGCGGCTGCAGTGGCCCCAGCCTCAGCAGCGGCACCGGCGGTGGCTGCGGTGTGGGTGGCCGGAACTGGGGTGGTGAAGA
AGCGGTGGTGGCGGCTGAAGGAGCGGTAGCAGCCTCAGCCTCTTTCCCTGTGCTTCCTTTCCTCTTTAGTGCAGCGAGGAAGTTTTCGCT
TCTGTACATGTGTTTGTGTGCGTGAGTGTGGGTGTGTGCGGTGAGGTTTGGGTGGCGTTTGTGCAGGCGTTGGGTTTTTTGCCCACTTGG
CTTCCCGTAACCCAGGCAGCTGGGGAGCCTGGGCTGTGGCCCTAGGAGGGGGCGCGGCGGCGGGCTCTCTCCTTTTGTTGTTGTTTCCTC
AGCCTGGGGAGCTGAAGGGGAGACGCGTCTGGGTGGGGCTGCTCGGAGCCCGGGCCTGGTGGCCCCTGGGGCTCCCGGGCGGGCAGGGTA
GGGCAGAGTAGAGCGGGCTTCAACATGATGGCGGCCGAGGCCGGCAGTGAGGAGGGCGGCCCGGTAACAGCCGGAGCTGGAGGAGGCGGC
GCGGCAGCGGGCTCCAGTGCCTATCCCGCAGTGTGTCGGGTGAAGATACCCGCGGCCCTGCCTGTGGCAGCCGCCCCCTATCCTGGGCTG
GTGGAGACCGGAGTGGCTGGAACTCTGGGTGGCGGAGCCGCTTTGGGGTCAGAGTTCCTAGGAGCCGGGTCTGTGGCAGGGGCACTGGGG
GGAGCTGGACTGACAGGGGGAGGTACTGCTGCTGGCGTAGCTGGTGCTGCTGCTGGCGTGGCCGGTGCTGCTGTTGCTGGACCTAGTGGA
GACATGGCTCTCACCAAACTGCCCACTTCGTTGCTTGCTGAGACTCTCGGGCCAGGCGGCGGTTTTCCCCCTCTGCCCCCTCCCCCTTAC
CTGCCCCCTTTGGGGGCGGGCCTCGGGACAGTGGACGAAGGTGACTCTCTGGATGGACCAGAATACGAGGAGGAAGAGGTGGCCATACCG
TTGACCGCTCCTCCAACTAACCAGTGGTATCACGGAAAACTTGACAGAACGATAGCAGAAGAACGCCTCAGGCAGGCAGGGAAGTCTGGC
AGTTATCTTATAAGAGAGAGTGATCGGAGGCCAGGGTCCTTTGTACTTTCATTTCTTAGCCAGATGAATGTTGTCAACCATTTTAGGATT
ATTGCTATGTGTGGAGATTACTACATTGGTGGAAGACGTTTTTCTTCACTGTCAGACCTAATAGGTTATTACAGTCATGTTTCTTGTTTG
CTTAAAGGAGAAAAATTACTTTACCCAGTTGCACCACCAGAGCCAGTAGAAGATAGAAGGCGTGTACGAGCTATTCTACCTTACACAAAA
GTACCAGACACTGATGAAATAAGTTTCTTAAAAGGAGATATGTTCATTGTTCATAATGAATTAGAAGATGGATGGATGTGGGTTACAAAT
TTAAGAACAGATGAACAAGGCCTTATTGTTGAAGACCTAGTAGAAGAGGTGGGCCGGGAAGAAGATCCACATGAAGGAAAAATATGGTTC
CATGGGAAGATTTCCAAACAGGAAGCTTATAATTTACTAATGACAGTTGGTCAAGTCTGCAGTTTTCTTGTGAGGCCCTCAGATAATACT
CCTGGCGATTATTCACTTTATTTCCGGACCAATGAAAATATTCAGCGATTTAAAATATGTCCAACGCCAAACAATCAGTTTATGATGGGA
GGCCGGTATTATAACAGTTCTAGGCCTGATTCTTCACTACCTGAGACGTCTAAAAAGGAGCACATCTCAGCTGAAAACATGTCTTTAGAA
ACTCTGAGAAACAGCAGCCCAGAAGACCTCTTTGATGAGATTTAACAGTCTCAAAAAATACTTTGATGTTCACTAGACTATGTTTTCTAT
TCATTTCTTTAAAATGAAAAAGGAGAATTTCAAGTCAGCAGCCGCTATTACCGTATCTTACAATTTAATTACATACACAGTGAATTGAAA
CCATTGTGCAAAATGGATTACACATGTATACAAAGATACGATTTGATGATGACACTGGCACATTATTCTAAACTATTCATTCAGCATGCC
TATAATTACATAAATTGTATGAGACTTTTTGTTGCAAAGGACACATTTATCATATTCATTCACACATATTATATGTGATAGCTGTCCAAC
ATCCTGTCTGGGAAGATTTTGAAAACAGGACAAAGAAAACATCATTTTAAAATGTCTTCAGCTTTTTTTGAATAGACGTATTCAAACATA

>72378_72378_1_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000274376_XRCC4_chr5_82648944_ENST00000338635_length(amino acids)=456AA_BP=417
MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGTLGGGAALGSEFLGAGSVAGALGGAGLTGGG
TAAGVAGAAAGVAGAAVAGPSGDMALTKLPTSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLY
PVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE
AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSSRPDSSLPETSKKEHISAENMSLETLRNSSPE

--------------------------------------------------------------
>72378_72378_2_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000274376_XRCC4_chr5_82648944_ENST00000396027_length(transcript)=2398nt_BP=1817nt
CTGAGAGCTCCAGGTAGTGAGCAGTTCAGTCGATTTCCTCGTTACCCCGCCCCCCTTTCTCTTGCCCCCCCACCCCTCTCATCTGCCTGG
TGGAGGATGAAGCGGCTGCAGTGGCCCCAGCCTCAGCAGCGGCACCGGCGGTGGCTGCGGTGTGGGTGGCCGGAACTGGGGTGGTGAAGA
AGCGGTGGTGGCGGCTGAAGGAGCGGTAGCAGCCTCAGCCTCTTTCCCTGTGCTTCCTTTCCTCTTTAGTGCAGCGAGGAAGTTTTCGCT
TCTGTACATGTGTTTGTGTGCGTGAGTGTGGGTGTGTGCGGTGAGGTTTGGGTGGCGTTTGTGCAGGCGTTGGGTTTTTTGCCCACTTGG
CTTCCCGTAACCCAGGCAGCTGGGGAGCCTGGGCTGTGGCCCTAGGAGGGGGCGCGGCGGCGGGCTCTCTCCTTTTGTTGTTGTTTCCTC
AGCCTGGGGAGCTGAAGGGGAGACGCGTCTGGGTGGGGCTGCTCGGAGCCCGGGCCTGGTGGCCCCTGGGGCTCCCGGGCGGGCAGGGTA
GGGCAGAGTAGAGCGGGCTTCAACATGATGGCGGCCGAGGCCGGCAGTGAGGAGGGCGGCCCGGTAACAGCCGGAGCTGGAGGAGGCGGC
GCGGCAGCGGGCTCCAGTGCCTATCCCGCAGTGTGTCGGGTGAAGATACCCGCGGCCCTGCCTGTGGCAGCCGCCCCCTATCCTGGGCTG
GTGGAGACCGGAGTGGCTGGAACTCTGGGTGGCGGAGCCGCTTTGGGGTCAGAGTTCCTAGGAGCCGGGTCTGTGGCAGGGGCACTGGGG
GGAGCTGGACTGACAGGGGGAGGTACTGCTGCTGGCGTAGCTGGTGCTGCTGCTGGCGTGGCCGGTGCTGCTGTTGCTGGACCTAGTGGA
GACATGGCTCTCACCAAACTGCCCACTTCGTTGCTTGCTGAGACTCTCGGGCCAGGCGGCGGTTTTCCCCCTCTGCCCCCTCCCCCTTAC
CTGCCCCCTTTGGGGGCGGGCCTCGGGACAGTGGACGAAGGTGACTCTCTGGATGGACCAGAATACGAGGAGGAAGAGGTGGCCATACCG
TTGACCGCTCCTCCAACTAACCAGTGGTATCACGGAAAACTTGACAGAACGATAGCAGAAGAACGCCTCAGGCAGGCAGGGAAGTCTGGC
AGTTATCTTATAAGAGAGAGTGATCGGAGGCCAGGGTCCTTTGTACTTTCATTTCTTAGCCAGATGAATGTTGTCAACCATTTTAGGATT
ATTGCTATGTGTGGAGATTACTACATTGGTGGAAGACGTTTTTCTTCACTGTCAGACCTAATAGGTTATTACAGTCATGTTTCTTGTTTG
CTTAAAGGAGAAAAATTACTTTACCCAGTTGCACCACCAGAGCCAGTAGAAGATAGAAGGCGTGTACGAGCTATTCTACCTTACACAAAA
GTACCAGACACTGATGAAATAAGTTTCTTAAAAGGAGATATGTTCATTGTTCATAATGAATTAGAAGATGGATGGATGTGGGTTACAAAT
TTAAGAACAGATGAACAAGGCCTTATTGTTGAAGACCTAGTAGAAGAGGTGGGCCGGGAAGAAGATCCACATGAAGGAAAAATATGGTTC
CATGGGAAGATTTCCAAACAGGAAGCTTATAATTTACTAATGACAGTTGGTCAAGTCTGCAGTTTTCTTGTGAGGCCCTCAGATAATACT
CCTGGCGATTATTCACTTTATTTCCGGACCAATGAAAATATTCAGCGATTTAAAATATGTCCAACGCCAAACAATCAGTTTATGATGGGA
GGCCGGTATTATAACAGGCCTGATTCTTCACTACCTGAGACGTCTAAAAAGGAGCACATCTCAGCTGAAAACATGTCTTTAGAAACTCTG
AGAAACAGCAGCCCAGAAGACCTCTTTGATGAGATTTAACAGTCTCAAAAAATACTTTGATGTTCACTAGACTATGTTTTCTATTCATTT
CTTTAAAATGAAAAAGGAGAATTTCAAGTCAGCAGCCGCTATTACCGTATCTTACAATTTAATTACATACACAGTGAATTGAAACCATTG
TGCAAAATGGATTACACATGTATACAAAGATACGATTTGATGATGACACTGGCACATTATTCTAAACTATTCATTCAGCATGCCTATAAT
TACATAAATTGTATGAGACTTTTTGTTGCAAAGGACACATTTATCATATTCATTCACACATATTATATGTGATAGCTGTCCAACATCCTG
TCTGGGAAGATTTTGAAAACAGGACAAAGAAAACATCATTTTAAAATGTCTTCAGCTTTTTTTGAATAGACGTATTCAAACATATTCTGA

>72378_72378_2_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000274376_XRCC4_chr5_82648944_ENST00000396027_length(amino acids)=454AA_BP=417
MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGTLGGGAALGSEFLGAGSVAGALGGAGLTGGG
TAAGVAGAAAGVAGAAVAGPSGDMALTKLPTSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLY
PVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE
AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNRPDSSLPETSKKEHISAENMSLETLRNSSPEDL

--------------------------------------------------------------
>72378_72378_3_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000456692_XRCC4_chr5_82648944_ENST00000338635_length(transcript)=1424nt_BP=837nt
GACCAGAATACGAGGAGGAAGAGGTGGCCATACCGTTGACCGCTCCTCCAACTAACCAGTAAGTTAAGACTGCTGTTCAGGAATTTGGGA
AGCTGGCTCCAGAAAAGAAGTGGAAATGAAGGGGTGGTATCACGGAAAACTTGACAGAACGATAGCAGAAGAACGCCTCAGGCAGGCAGG
GAAGTCTGGCAGTTATCTTATAAGAGAGAGTGATCGGAGGCCAGGGTCCTTTGTACTTTCATTTCTTAGCCAGATGAATGTTGTCAACCA
TTTTAGGATTATTGCTATGTGTGGAGATTACTACATTGGTGGAAGACGTTTTTCTTCACTGTCAGACCTAATAGGTTATTACAGTCATGT
TTCTTGTTTGCTTAAAGGAGAAAAATTACTTTACCCAGTTGCACCACCAGAGCCAGTAGAAGATAGAAGGCGTGTACGAGCTATTCTACC
TTACACAAAAGTACCAGACACTGATGAAATAAGTTTCTTAAAAGGAGATATGTTCATTGTTCATAATGAATTAGAAGATGGATGGATGTG
GGTTACAAATTTAAGAACAGATGAACAAGGCCTTATTGTTGAAGACCTAGTAGAAGAGGTGGGCCGGGAAGAAGATCCACATGAAGGAAA
AATATGGTTCCATGGGAAGATTTCCAAACAGGAAGCTTATAATTTACTAATGACAGTTGGTCAAGTCTGCAGTTTTCTTGTGAGGCCCTC
AGATAATACTCCTGGCGATTATTCACTTTATTTCCGGACCAATGAAAATATTCAGCGATTTAAAATATGTCCAACGCCAAACAATCAGTT
TATGATGGGAGGCCGGTATTATAACAGTTCTAGGCCTGATTCTTCACTACCTGAGACGTCTAAAAAGGAGCACATCTCAGCTGAAAACAT
GTCTTTAGAAACTCTGAGAAACAGCAGCCCAGAAGACCTCTTTGATGAGATTTAACAGTCTCAAAAAATACTTTGATGTTCACTAGACTA
TGTTTTCTATTCATTTCTTTAAAATGAAAAAGGAGAATTTCAAGTCAGCAGCCGCTATTACCGTATCTTACAATTTAATTACATACACAG
TGAATTGAAACCATTGTGCAAAATGGATTACACATGTATACAAAGATACGATTTGATGATGACACTGGCACATTATTCTAAACTATTCAT
TCAGCATGCCTATAATTACATAAATTGTATGAGACTTTTTGTTGCAAAGGACACATTTATCATATTCATTCACACATATTATATGTGATA
GCTGTCCAACATCCTGTCTGGGAAGATTTTGAAAACAGGACAAAGAAAACATCATTTTAAAATGTCTTCAGCTTTTTTTGAATAGACGTA

>72378_72378_3_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000456692_XRCC4_chr5_82648944_ENST00000338635_length(amino acids)=279AA_BP=240
MKGWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEK
LLYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKIS
KQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSSRPDSSLPETSKKEHISAENMSLETLRNS

--------------------------------------------------------------
>72378_72378_4_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000456692_XRCC4_chr5_82648944_ENST00000396027_length(transcript)=1418nt_BP=837nt
GACCAGAATACGAGGAGGAAGAGGTGGCCATACCGTTGACCGCTCCTCCAACTAACCAGTAAGTTAAGACTGCTGTTCAGGAATTTGGGA
AGCTGGCTCCAGAAAAGAAGTGGAAATGAAGGGGTGGTATCACGGAAAACTTGACAGAACGATAGCAGAAGAACGCCTCAGGCAGGCAGG
GAAGTCTGGCAGTTATCTTATAAGAGAGAGTGATCGGAGGCCAGGGTCCTTTGTACTTTCATTTCTTAGCCAGATGAATGTTGTCAACCA
TTTTAGGATTATTGCTATGTGTGGAGATTACTACATTGGTGGAAGACGTTTTTCTTCACTGTCAGACCTAATAGGTTATTACAGTCATGT
TTCTTGTTTGCTTAAAGGAGAAAAATTACTTTACCCAGTTGCACCACCAGAGCCAGTAGAAGATAGAAGGCGTGTACGAGCTATTCTACC
TTACACAAAAGTACCAGACACTGATGAAATAAGTTTCTTAAAAGGAGATATGTTCATTGTTCATAATGAATTAGAAGATGGATGGATGTG
GGTTACAAATTTAAGAACAGATGAACAAGGCCTTATTGTTGAAGACCTAGTAGAAGAGGTGGGCCGGGAAGAAGATCCACATGAAGGAAA
AATATGGTTCCATGGGAAGATTTCCAAACAGGAAGCTTATAATTTACTAATGACAGTTGGTCAAGTCTGCAGTTTTCTTGTGAGGCCCTC
AGATAATACTCCTGGCGATTATTCACTTTATTTCCGGACCAATGAAAATATTCAGCGATTTAAAATATGTCCAACGCCAAACAATCAGTT
TATGATGGGAGGCCGGTATTATAACAGGCCTGATTCTTCACTACCTGAGACGTCTAAAAAGGAGCACATCTCAGCTGAAAACATGTCTTT
AGAAACTCTGAGAAACAGCAGCCCAGAAGACCTCTTTGATGAGATTTAACAGTCTCAAAAAATACTTTGATGTTCACTAGACTATGTTTT
CTATTCATTTCTTTAAAATGAAAAAGGAGAATTTCAAGTCAGCAGCCGCTATTACCGTATCTTACAATTTAATTACATACACAGTGAATT
GAAACCATTGTGCAAAATGGATTACACATGTATACAAAGATACGATTTGATGATGACACTGGCACATTATTCTAAACTATTCATTCAGCA
TGCCTATAATTACATAAATTGTATGAGACTTTTTGTTGCAAAGGACACATTTATCATATTCATTCACACATATTATATGTGATAGCTGTC
CAACATCCTGTCTGGGAAGATTTTGAAAACAGGACAAAGAAAACATCATTTTAAAATGTCTTCAGCTTTTTTTGAATAGACGTATTCAAA

>72378_72378_4_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000456692_XRCC4_chr5_82648944_ENST00000396027_length(amino acids)=277AA_BP=240
MKGWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEK
LLYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKIS
KQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNRPDSSLPETSKKEHISAENMSLETLRNSSP

--------------------------------------------------------------
>72378_72378_5_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000506290_XRCC4_chr5_82648944_ENST00000338635_length(transcript)=1459nt_BP=872nt
GAGGAGGAAGAGGTGGCCATACCGTTGACCGCTCCTCCAACTAACCAGTAAGTTAAGACTGCTGTTCAGGAATTTGGGAAGCTGGCTCCA
GAAAAGAAGTGGAAATGAAGGGGTTCCATGTGCCTTGTGAAGTCATGGTTCCTCAGTATAAGATCGAGGTGGTATCACGGAAAACTTGAC
AGAACGATAGCAGAAGAACGCCTCAGGCAGGCAGGGAAGTCTGGCAGTTATCTTATAAGAGAGAGTGATCGGAGGCCAGGGTCCTTTGTA
CTTTCATTTCTTAGCCAGATGAATGTTGTCAACCATTTTAGGATTATTGCTATGTGTGGAGATTACTACATTGGTGGAAGACGTTTTTCT
TCACTGTCAGACCTAATAGGTTATTACAGTCATGTTTCTTGTTTGCTTAAAGGAGAAAAATTACTTTACCCAGTTGCACCACCAGAGCCA
GTAGAAGATAGAAGGCGTGTACGAGCTATTCTACCTTACACAAAAGTACCAGACACTGATGAAATAAGTTTCTTAAAAGGAGATATGTTC
ATTGTTCATAATGAATTAGAAGATGGATGGATGTGGGTTACAAATTTAAGAACAGATGAACAAGGCCTTATTGTTGAAGACCTAGTAGAA
GAGGTGGGCCGGGAAGAAGATCCACATGAAGGAAAAATATGGTTCCATGGGAAGATTTCCAAACAGGAAGCTTATAATTTACTAATGACA
GTTGGTCAAGTCTGCAGTTTTCTTGTGAGGCCCTCAGATAATACTCCTGGCGATTATTCACTTTATTTCCGGACCAATGAAAATATTCAG
CGATTTAAAATATGTCCAACGCCAAACAATCAGTTTATGATGGGAGGCCGGTATTATAACAGTTCTAGGCCTGATTCTTCACTACCTGAG
ACGTCTAAAAAGGAGCACATCTCAGCTGAAAACATGTCTTTAGAAACTCTGAGAAACAGCAGCCCAGAAGACCTCTTTGATGAGATTTAA
CAGTCTCAAAAAATACTTTGATGTTCACTAGACTATGTTTTCTATTCATTTCTTTAAAATGAAAAAGGAGAATTTCAAGTCAGCAGCCGC
TATTACCGTATCTTACAATTTAATTACATACACAGTGAATTGAAACCATTGTGCAAAATGGATTACACATGTATACAAAGATACGATTTG
ATGATGACACTGGCACATTATTCTAAACTATTCATTCAGCATGCCTATAATTACATAAATTGTATGAGACTTTTTGTTGCAAAGGACACA
TTTATCATATTCATTCACACATATTATATGTGATAGCTGTCCAACATCCTGTCTGGGAAGATTTTGAAAACAGGACAAAGAAAACATCAT
TTTAAAATGTCTTCAGCTTTTTTTGAATAGACGTATTCAAACATATTCTGAACATTGATGTTTGAACATTTTAATTTGTGTGATGATGTA

>72378_72378_5_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000506290_XRCC4_chr5_82648944_ENST00000338635_length(amino acids)=290AA_BP=251
MCLVKSWFLSIRSRWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYY
SHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPH
EGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSSRPDSSLPETSKKEHISA

--------------------------------------------------------------
>72378_72378_6_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000506290_XRCC4_chr5_82648944_ENST00000396027_length(transcript)=1453nt_BP=872nt
GAGGAGGAAGAGGTGGCCATACCGTTGACCGCTCCTCCAACTAACCAGTAAGTTAAGACTGCTGTTCAGGAATTTGGGAAGCTGGCTCCA
GAAAAGAAGTGGAAATGAAGGGGTTCCATGTGCCTTGTGAAGTCATGGTTCCTCAGTATAAGATCGAGGTGGTATCACGGAAAACTTGAC
AGAACGATAGCAGAAGAACGCCTCAGGCAGGCAGGGAAGTCTGGCAGTTATCTTATAAGAGAGAGTGATCGGAGGCCAGGGTCCTTTGTA
CTTTCATTTCTTAGCCAGATGAATGTTGTCAACCATTTTAGGATTATTGCTATGTGTGGAGATTACTACATTGGTGGAAGACGTTTTTCT
TCACTGTCAGACCTAATAGGTTATTACAGTCATGTTTCTTGTTTGCTTAAAGGAGAAAAATTACTTTACCCAGTTGCACCACCAGAGCCA
GTAGAAGATAGAAGGCGTGTACGAGCTATTCTACCTTACACAAAAGTACCAGACACTGATGAAATAAGTTTCTTAAAAGGAGATATGTTC
ATTGTTCATAATGAATTAGAAGATGGATGGATGTGGGTTACAAATTTAAGAACAGATGAACAAGGCCTTATTGTTGAAGACCTAGTAGAA
GAGGTGGGCCGGGAAGAAGATCCACATGAAGGAAAAATATGGTTCCATGGGAAGATTTCCAAACAGGAAGCTTATAATTTACTAATGACA
GTTGGTCAAGTCTGCAGTTTTCTTGTGAGGCCCTCAGATAATACTCCTGGCGATTATTCACTTTATTTCCGGACCAATGAAAATATTCAG
CGATTTAAAATATGTCCAACGCCAAACAATCAGTTTATGATGGGAGGCCGGTATTATAACAGGCCTGATTCTTCACTACCTGAGACGTCT
AAAAAGGAGCACATCTCAGCTGAAAACATGTCTTTAGAAACTCTGAGAAACAGCAGCCCAGAAGACCTCTTTGATGAGATTTAACAGTCT
CAAAAAATACTTTGATGTTCACTAGACTATGTTTTCTATTCATTTCTTTAAAATGAAAAAGGAGAATTTCAAGTCAGCAGCCGCTATTAC
CGTATCTTACAATTTAATTACATACACAGTGAATTGAAACCATTGTGCAAAATGGATTACACATGTATACAAAGATACGATTTGATGATG
ACACTGGCACATTATTCTAAACTATTCATTCAGCATGCCTATAATTACATAAATTGTATGAGACTTTTTGTTGCAAAGGACACATTTATC
ATATTCATTCACACATATTATATGTGATAGCTGTCCAACATCCTGTCTGGGAAGATTTTGAAAACAGGACAAAGAAAACATCATTTTAAA
ATGTCTTCAGCTTTTTTTGAATAGACGTATTCAAACATATTCTGAACATTGATGTTTGAACATTTTAATTTGTGTGATGATGTAGAAAAT

>72378_72378_6_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000506290_XRCC4_chr5_82648944_ENST00000396027_length(amino acids)=288AA_BP=251
MCLVKSWFLSIRSRWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYY
SHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPH
EGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNRPDSSLPETSKKEHISAEN

--------------------------------------------------------------
>72378_72378_7_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000512763_XRCC4_chr5_82648944_ENST00000338635_length(transcript)=1540nt_BP=953nt
GAGGAGGAAGAGGTGGCCATACCGTTGACCGCTCCTCCAACTAACCAGTAAGTTAAGACTGCTGTTCAGGAATTTGGGAAGCTGGCTCCA
GAAAAGAAGTGGAAATGAAGGGGCATACTACCTGGCGTCTTCCTACATTTATTGCTCCTCTGGGAAAGTGTAAAGTCTTTAAGATGGAAA
GCATGAGAAAATGTGTATCTAATGAGAACCGGATATAGTTCTGTCCCTTCCAAGTTGAGGTGGTATCACGGAAAACTTGACAGAACGATA
GCAGAAGAACGCCTCAGGCAGGCAGGGAAGTCTGGCAGTTATCTTATAAGAGAGAGTGATCGGAGGCCAGGGTCCTTTGTACTTTCATTT
CTTAGCCAGATGAATGTTGTCAACCATTTTAGGATTATTGCTATGTGTGGAGATTACTACATTGGTGGAAGACGTTTTTCTTCACTGTCA
GACCTAATAGGTTATTACAGTCATGTTTCTTGTTTGCTTAAAGGAGAAAAATTACTTTACCCAGTTGCACCACCAGAGCCAGTAGAAGAT
AGAAGGCGTGTACGAGCTATTCTACCTTACACAAAAGTACCAGACACTGATGAAATAAGTTTCTTAAAAGGAGATATGTTCATTGTTCAT
AATGAATTAGAAGATGGATGGATGTGGGTTACAAATTTAAGAACAGATGAACAAGGCCTTATTGTTGAAGACCTAGTAGAAGAGGTGGGC
CGGGAAGAAGATCCACATGAAGGAAAAATATGGTTCCATGGGAAGATTTCCAAACAGGAAGCTTATAATTTACTAATGACAGTTGGTCAA
GTCTGCAGTTTTCTTGTGAGGCCCTCAGATAATACTCCTGGCGATTATTCACTTTATTTCCGGACCAATGAAAATATTCAGCGATTTAAA
ATATGTCCAACGCCAAACAATCAGTTTATGATGGGAGGCCGGTATTATAACAGTTCTAGGCCTGATTCTTCACTACCTGAGACGTCTAAA
AAGGAGCACATCTCAGCTGAAAACATGTCTTTAGAAACTCTGAGAAACAGCAGCCCAGAAGACCTCTTTGATGAGATTTAACAGTCTCAA
AAAATACTTTGATGTTCACTAGACTATGTTTTCTATTCATTTCTTTAAAATGAAAAAGGAGAATTTCAAGTCAGCAGCCGCTATTACCGT
ATCTTACAATTTAATTACATACACAGTGAATTGAAACCATTGTGCAAAATGGATTACACATGTATACAAAGATACGATTTGATGATGACA
CTGGCACATTATTCTAAACTATTCATTCAGCATGCCTATAATTACATAAATTGTATGAGACTTTTTGTTGCAAAGGACACATTTATCATA
TTCATTCACACATATTATATGTGATAGCTGTCCAACATCCTGTCTGGGAAGATTTTGAAAACAGGACAAAGAAAACATCATTTTAAAATG
TCTTCAGCTTTTTTTGAATAGACGTATTCAAACATATTCTGAACATTGATGTTTGAACATTTTAATTTGTGTGATGATGTAGAAAATATA

>72378_72378_7_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000512763_XRCC4_chr5_82648944_ENST00000338635_length(amino acids)=289AA_BP=250
MRTGYSSVPSKLRWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYS
HVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHE
GKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSSRPDSSLPETSKKEHISAE

--------------------------------------------------------------
>72378_72378_8_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000512763_XRCC4_chr5_82648944_ENST00000396027_length(transcript)=1534nt_BP=953nt
GAGGAGGAAGAGGTGGCCATACCGTTGACCGCTCCTCCAACTAACCAGTAAGTTAAGACTGCTGTTCAGGAATTTGGGAAGCTGGCTCCA
GAAAAGAAGTGGAAATGAAGGGGCATACTACCTGGCGTCTTCCTACATTTATTGCTCCTCTGGGAAAGTGTAAAGTCTTTAAGATGGAAA
GCATGAGAAAATGTGTATCTAATGAGAACCGGATATAGTTCTGTCCCTTCCAAGTTGAGGTGGTATCACGGAAAACTTGACAGAACGATA
GCAGAAGAACGCCTCAGGCAGGCAGGGAAGTCTGGCAGTTATCTTATAAGAGAGAGTGATCGGAGGCCAGGGTCCTTTGTACTTTCATTT
CTTAGCCAGATGAATGTTGTCAACCATTTTAGGATTATTGCTATGTGTGGAGATTACTACATTGGTGGAAGACGTTTTTCTTCACTGTCA
GACCTAATAGGTTATTACAGTCATGTTTCTTGTTTGCTTAAAGGAGAAAAATTACTTTACCCAGTTGCACCACCAGAGCCAGTAGAAGAT
AGAAGGCGTGTACGAGCTATTCTACCTTACACAAAAGTACCAGACACTGATGAAATAAGTTTCTTAAAAGGAGATATGTTCATTGTTCAT
AATGAATTAGAAGATGGATGGATGTGGGTTACAAATTTAAGAACAGATGAACAAGGCCTTATTGTTGAAGACCTAGTAGAAGAGGTGGGC
CGGGAAGAAGATCCACATGAAGGAAAAATATGGTTCCATGGGAAGATTTCCAAACAGGAAGCTTATAATTTACTAATGACAGTTGGTCAA
GTCTGCAGTTTTCTTGTGAGGCCCTCAGATAATACTCCTGGCGATTATTCACTTTATTTCCGGACCAATGAAAATATTCAGCGATTTAAA
ATATGTCCAACGCCAAACAATCAGTTTATGATGGGAGGCCGGTATTATAACAGGCCTGATTCTTCACTACCTGAGACGTCTAAAAAGGAG
CACATCTCAGCTGAAAACATGTCTTTAGAAACTCTGAGAAACAGCAGCCCAGAAGACCTCTTTGATGAGATTTAACAGTCTCAAAAAATA
CTTTGATGTTCACTAGACTATGTTTTCTATTCATTTCTTTAAAATGAAAAAGGAGAATTTCAAGTCAGCAGCCGCTATTACCGTATCTTA
CAATTTAATTACATACACAGTGAATTGAAACCATTGTGCAAAATGGATTACACATGTATACAAAGATACGATTTGATGATGACACTGGCA
CATTATTCTAAACTATTCATTCAGCATGCCTATAATTACATAAATTGTATGAGACTTTTTGTTGCAAAGGACACATTTATCATATTCATT
CACACATATTATATGTGATAGCTGTCCAACATCCTGTCTGGGAAGATTTTGAAAACAGGACAAAGAAAACATCATTTTAAAATGTCTTCA
GCTTTTTTTGAATAGACGTATTCAAACATATTCTGAACATTGATGTTTGAACATTTTAATTTGTGTGATGATGTAGAAAATATAATTTTA

>72378_72378_8_RASA1-XRCC4_RASA1_chr5_86645181_ENST00000512763_XRCC4_chr5_82648944_ENST00000396027_length(amino acids)=287AA_BP=250
MRTGYSSVPSKLRWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYS
HVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHE
GKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNRPDSSLPETSKKEHISAENM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RASA1-XRCC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneXRCC4chr5:86645181chr5:82648944ENST00000282268681_213297.6666666666667335.0IFFO1
TgeneXRCC4chr5:86645181chr5:82648944ENST00000338635681_213297.6666666666667337.0IFFO1
TgeneXRCC4chr5:86645181chr5:82648944ENST00000396027681_213297.6666666666667335.0IFFO1
TgeneXRCC4chr5:86645181chr5:82648944ENST00000511817681_213297.6666666666667337.0IFFO1
TgeneXRCC4chr5:86645181chr5:82648944ENST0000028226868180_213297.6666666666667335.0LIG4
TgeneXRCC4chr5:86645181chr5:82648944ENST0000033863568180_213297.6666666666667337.0LIG4
TgeneXRCC4chr5:86645181chr5:82648944ENST0000039602768180_213297.6666666666667335.0LIG4
TgeneXRCC4chr5:86645181chr5:82648944ENST0000051181768180_213297.6666666666667337.0LIG4


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RASA1-XRCC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RASA1-XRCC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource