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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RASAL1-DDX54 (FusionGDB2 ID:72413)

Fusion Gene Summary for RASAL1-DDX54

check button Fusion gene summary
Fusion gene informationFusion gene name: RASAL1-DDX54
Fusion gene ID: 72413
HgeneTgene
Gene symbol

RASAL1

DDX54

Gene ID

8437

79039

Gene nameRAS protein activator like 1DEAD-box helicase 54
SynonymsRASALDP97
Cytomap

12q24.13

12q24.13

Type of geneprotein-codingprotein-coding
DescriptionrasGAP-activating-like protein 1GAP1 like proteinras GTPase-activating-like proteinATP-dependent RNA helicase DDX54ATP-dependent RNA helicase DP97DEAD (Asp-Glu-Ala-Asp) box polypeptide 54DEAD box RNA helicase 97 kDaDEAD box helicase 97 KDaDEAD box protein 54
Modification date2020031320200322
UniProtAcc.

Q8TDD1

Ensembl transtripts involved in fusion geneENST00000261729, ENST00000446861, 
ENST00000546530, ENST00000548055, 
ENST00000418411, 		ENST00000549271, 
ENST00000306014, ENST00000314045, 
Fusion gene scores* DoF score3 X 6 X 4=723 X 6 X 4=72
# samples 66
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RASAL1 [Title/Abstract] AND DDX54 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRASAL1(113552605)-DDX54(113603837), # samples:3
Anticipated loss of major functional domain due to fusion event.RASAL1-DDX54 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
RASAL1-DDX54 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRASAL1

GO:1903861

positive regulation of dendrite extension

23999003

TgeneDDX54

GO:0006396

RNA processing

12466272

TgeneDDX54

GO:0016070

RNA metabolic process

12466272


check buttonFusion gene breakpoints across RASAL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DDX54 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-JW-A5VJ-01ARASAL1chr12

113545890

-DDX54chr12

113616831

-
ChimerDB4KIRPTCGA-A4-A5Y0-01ARASAL1chr12

113552605

-DDX54chr12

113603837

-
ChimerDB4KIRPTCGA-A4-A5Y0RASAL1chr12

113552605

-DDX54chr12

113603837

-
ChimerDB4UCECTCGA-EY-A2ON-01ARASAL1chr12

113553739

-DDX54chr12

113596914

-
ChimerDB4UCECTCGA-EY-A2ONRASAL1chr12

113553738

-DDX54chr12

113596917

-


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Fusion Gene ORF analysis for RASAL1-DDX54

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261729ENST00000549271RASAL1chr12

113553739

-DDX54chr12

113596914

-
5CDS-5UTRENST00000261729ENST00000549271RASAL1chr12

113553738

-DDX54chr12

113596917

-
5CDS-5UTRENST00000446861ENST00000549271RASAL1chr12

113553739

-DDX54chr12

113596914

-
5CDS-5UTRENST00000446861ENST00000549271RASAL1chr12

113553738

-DDX54chr12

113596917

-
5CDS-5UTRENST00000546530ENST00000549271RASAL1chr12

113553739

-DDX54chr12

113596914

-
5CDS-5UTRENST00000546530ENST00000549271RASAL1chr12

113553738

-DDX54chr12

113596917

-
5CDS-5UTRENST00000548055ENST00000549271RASAL1chr12

113553739

-DDX54chr12

113596914

-
5CDS-5UTRENST00000548055ENST00000549271RASAL1chr12

113553738

-DDX54chr12

113596917

-
5CDS-intronENST00000261729ENST00000549271RASAL1chr12

113545890

-DDX54chr12

113616831

-
5CDS-intronENST00000261729ENST00000549271RASAL1chr12

113552605

-DDX54chr12

113603837

-
5CDS-intronENST00000446861ENST00000549271RASAL1chr12

113545890

-DDX54chr12

113616831

-
5CDS-intronENST00000446861ENST00000549271RASAL1chr12

113552605

-DDX54chr12

113603837

-
5CDS-intronENST00000546530ENST00000549271RASAL1chr12

113545890

-DDX54chr12

113616831

-
5CDS-intronENST00000546530ENST00000549271RASAL1chr12

113552605

-DDX54chr12

113603837

-
5CDS-intronENST00000548055ENST00000549271RASAL1chr12

113545890

-DDX54chr12

113616831

-
5CDS-intronENST00000548055ENST00000549271RASAL1chr12

113552605

-DDX54chr12

113603837

-
5UTR-3CDSENST00000418411ENST00000306014RASAL1chr12

113545890

-DDX54chr12

113616831

-
5UTR-3CDSENST00000418411ENST00000306014RASAL1chr12

113552605

-DDX54chr12

113603837

-
5UTR-3CDSENST00000418411ENST00000306014RASAL1chr12

113553739

-DDX54chr12

113596914

-
5UTR-3CDSENST00000418411ENST00000306014RASAL1chr12

113553738

-DDX54chr12

113596917

-
5UTR-3CDSENST00000418411ENST00000314045RASAL1chr12

113545890

-DDX54chr12

113616831

-
5UTR-3CDSENST00000418411ENST00000314045RASAL1chr12

113552605

-DDX54chr12

113603837

-
5UTR-3CDSENST00000418411ENST00000314045RASAL1chr12

113553739

-DDX54chr12

113596914

-
5UTR-3CDSENST00000418411ENST00000314045RASAL1chr12

113553738

-DDX54chr12

113596917

-
5UTR-5UTRENST00000418411ENST00000549271RASAL1chr12

113553739

-DDX54chr12

113596914

-
5UTR-5UTRENST00000418411ENST00000549271RASAL1chr12

113553738

-DDX54chr12

113596917

-
5UTR-intronENST00000418411ENST00000549271RASAL1chr12

113545890

-DDX54chr12

113616831

-
5UTR-intronENST00000418411ENST00000549271RASAL1chr12

113552605

-DDX54chr12

113603837

-
Frame-shiftENST00000261729ENST00000306014RASAL1chr12

113545890

-DDX54chr12

113616831

-
Frame-shiftENST00000261729ENST00000306014RASAL1chr12

113552605

-DDX54chr12

113603837

-
Frame-shiftENST00000261729ENST00000314045RASAL1chr12

113545890

-DDX54chr12

113616831

-
Frame-shiftENST00000261729ENST00000314045RASAL1chr12

113552605

-DDX54chr12

113603837

-
Frame-shiftENST00000446861ENST00000306014RASAL1chr12

113552605

-DDX54chr12

113603837

-
Frame-shiftENST00000446861ENST00000306014RASAL1chr12

113553739

-DDX54chr12

113596914

-
Frame-shiftENST00000446861ENST00000306014RASAL1chr12

113553738

-DDX54chr12

113596917

-
Frame-shiftENST00000446861ENST00000314045RASAL1chr12

113552605

-DDX54chr12

113603837

-
Frame-shiftENST00000446861ENST00000314045RASAL1chr12

113553739

-DDX54chr12

113596914

-
Frame-shiftENST00000446861ENST00000314045RASAL1chr12

113553738

-DDX54chr12

113596917

-
Frame-shiftENST00000546530ENST00000306014RASAL1chr12

113545890

-DDX54chr12

113616831

-
Frame-shiftENST00000546530ENST00000306014RASAL1chr12

113552605

-DDX54chr12

113603837

-
Frame-shiftENST00000546530ENST00000314045RASAL1chr12

113545890

-DDX54chr12

113616831

-
Frame-shiftENST00000546530ENST00000314045RASAL1chr12

113552605

-DDX54chr12

113603837

-
Frame-shiftENST00000548055ENST00000306014RASAL1chr12

113552605

-DDX54chr12

113603837

-
Frame-shiftENST00000548055ENST00000306014RASAL1chr12

113553739

-DDX54chr12

113596914

-
Frame-shiftENST00000548055ENST00000306014RASAL1chr12

113553738

-DDX54chr12

113596917

-
Frame-shiftENST00000548055ENST00000314045RASAL1chr12

113552605

-DDX54chr12

113603837

-
Frame-shiftENST00000548055ENST00000314045RASAL1chr12

113553739

-DDX54chr12

113596914

-
Frame-shiftENST00000548055ENST00000314045RASAL1chr12

113553738

-DDX54chr12

113596917

-
In-frameENST00000261729ENST00000306014RASAL1chr12

113553739

-DDX54chr12

113596914

-
In-frameENST00000261729ENST00000306014RASAL1chr12

113553738

-DDX54chr12

113596917

-
In-frameENST00000261729ENST00000314045RASAL1chr12

113553739

-DDX54chr12

113596914

-
In-frameENST00000261729ENST00000314045RASAL1chr12

113553738

-DDX54chr12

113596917

-
In-frameENST00000446861ENST00000306014RASAL1chr12

113545890

-DDX54chr12

113616831

-
In-frameENST00000446861ENST00000314045RASAL1chr12

113545890

-DDX54chr12

113616831

-
In-frameENST00000546530ENST00000306014RASAL1chr12

113553739

-DDX54chr12

113596914

-
In-frameENST00000546530ENST00000306014RASAL1chr12

113553738

-DDX54chr12

113596917

-
In-frameENST00000546530ENST00000314045RASAL1chr12

113553739

-DDX54chr12

113596914

-
In-frameENST00000546530ENST00000314045RASAL1chr12

113553738

-DDX54chr12

113596917

-
In-frameENST00000548055ENST00000306014RASAL1chr12

113545890

-DDX54chr12

113616831

-
In-frameENST00000548055ENST00000314045RASAL1chr12

113545890

-DDX54chr12

113616831

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for RASAL1-DDX54


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RASAL1-DDX54


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:113552605/chr12:113603837)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DDX54

Q8TDD1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRASAL1chr12:113545890chr12:113616831ENST00000261729-1522499_502504805.0Compositional biasNote=Poly-Leu
HgeneRASAL1chr12:113545890chr12:113616831ENST00000446861-1421499_502504777.0Compositional biasNote=Poly-Leu
HgeneRASAL1chr12:113545890chr12:113616831ENST00000546530-1522499_502505807.0Compositional biasNote=Poly-Leu
HgeneRASAL1chr12:113545890chr12:113616831ENST00000548055-1421499_502504806.0Compositional biasNote=Poly-Leu
HgeneRASAL1chr12:113545890chr12:113616831ENST00000261729-1522116_231504805.0DomainC2 2
HgeneRASAL1chr12:113545890chr12:113616831ENST00000261729-15221_105504805.0DomainC2 1
HgeneRASAL1chr12:113545890chr12:113616831ENST00000446861-1421116_231504777.0DomainC2 2
HgeneRASAL1chr12:113545890chr12:113616831ENST00000446861-14211_105504777.0DomainC2 1
HgeneRASAL1chr12:113545890chr12:113616831ENST00000546530-1522116_231505807.0DomainC2 2
HgeneRASAL1chr12:113545890chr12:113616831ENST00000546530-15221_105505807.0DomainC2 1
HgeneRASAL1chr12:113545890chr12:113616831ENST00000548055-1421116_231504806.0DomainC2 2
HgeneRASAL1chr12:113545890chr12:113616831ENST00000548055-14211_105504806.0DomainC2 1
HgeneRASAL1chr12:113553738chr12:113596917ENST00000261729-1022116_231283805.0DomainC2 2
HgeneRASAL1chr12:113553738chr12:113596917ENST00000261729-10221_105283805.0DomainC2 1
HgeneRASAL1chr12:113553738chr12:113596917ENST00000446861-921116_231283777.0DomainC2 2
HgeneRASAL1chr12:113553738chr12:113596917ENST00000446861-9211_105283777.0DomainC2 1
HgeneRASAL1chr12:113553738chr12:113596917ENST00000546530-1022116_231283807.0DomainC2 2
HgeneRASAL1chr12:113553738chr12:113596917ENST00000546530-10221_105283807.0DomainC2 1
HgeneRASAL1chr12:113553738chr12:113596917ENST00000548055-921116_231283806.0DomainC2 2
HgeneRASAL1chr12:113553738chr12:113596917ENST00000548055-9211_105283806.0DomainC2 1
HgeneRASAL1chr12:113553739chr12:113596914ENST00000261729-1022116_231283805.0DomainC2 2
HgeneRASAL1chr12:113553739chr12:113596914ENST00000261729-10221_105283805.0DomainC2 1
HgeneRASAL1chr12:113553739chr12:113596914ENST00000446861-921116_231283777.0DomainC2 2
HgeneRASAL1chr12:113553739chr12:113596914ENST00000446861-9211_105283777.0DomainC2 1
HgeneRASAL1chr12:113553739chr12:113596914ENST00000546530-1022116_231283807.0DomainC2 2
HgeneRASAL1chr12:113553739chr12:113596914ENST00000546530-10221_105283807.0DomainC2 1
HgeneRASAL1chr12:113553739chr12:113596914ENST00000548055-921116_231283806.0DomainC2 2
HgeneRASAL1chr12:113553739chr12:113596914ENST00000548055-9211_105283806.0DomainC2 1
TgeneDDX54chr12:113545890chr12:113616831ENST00000306014320326_473188882.0DomainHelicase C-terminal
TgeneDDX54chr12:113545890chr12:113616831ENST00000314045320326_473188883.0DomainHelicase C-terminal
TgeneDDX54chr12:113545890chr12:113616831ENST00000306014320247_250188882.0MotifNote=DEAD box
TgeneDDX54chr12:113545890chr12:113616831ENST00000314045320247_250188883.0MotifNote=DEAD box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRASAL1chr12:113553738chr12:113596917ENST00000261729-1022499_502283805.0Compositional biasNote=Poly-Leu
HgeneRASAL1chr12:113553738chr12:113596917ENST00000446861-921499_502283777.0Compositional biasNote=Poly-Leu
HgeneRASAL1chr12:113553738chr12:113596917ENST00000546530-1022499_502283807.0Compositional biasNote=Poly-Leu
HgeneRASAL1chr12:113553738chr12:113596917ENST00000548055-921499_502283806.0Compositional biasNote=Poly-Leu
HgeneRASAL1chr12:113553739chr12:113596914ENST00000261729-1022499_502283805.0Compositional biasNote=Poly-Leu
HgeneRASAL1chr12:113553739chr12:113596914ENST00000446861-921499_502283777.0Compositional biasNote=Poly-Leu
HgeneRASAL1chr12:113553739chr12:113596914ENST00000546530-1022499_502283807.0Compositional biasNote=Poly-Leu
HgeneRASAL1chr12:113553739chr12:113596914ENST00000548055-921499_502283806.0Compositional biasNote=Poly-Leu
HgeneRASAL1chr12:113545890chr12:113616831ENST00000261729-1522301_511504805.0DomainRas-GAP
HgeneRASAL1chr12:113545890chr12:113616831ENST00000261729-1522565_672504805.0DomainPH
HgeneRASAL1chr12:113545890chr12:113616831ENST00000446861-1421301_511504777.0DomainRas-GAP
HgeneRASAL1chr12:113545890chr12:113616831ENST00000446861-1421565_672504777.0DomainPH
HgeneRASAL1chr12:113545890chr12:113616831ENST00000546530-1522301_511505807.0DomainRas-GAP
HgeneRASAL1chr12:113545890chr12:113616831ENST00000546530-1522565_672505807.0DomainPH
HgeneRASAL1chr12:113545890chr12:113616831ENST00000548055-1421301_511504806.0DomainRas-GAP
HgeneRASAL1chr12:113545890chr12:113616831ENST00000548055-1421565_672504806.0DomainPH
HgeneRASAL1chr12:113553738chr12:113596917ENST00000261729-1022301_511283805.0DomainRas-GAP
HgeneRASAL1chr12:113553738chr12:113596917ENST00000261729-1022565_672283805.0DomainPH
HgeneRASAL1chr12:113553738chr12:113596917ENST00000446861-921301_511283777.0DomainRas-GAP
HgeneRASAL1chr12:113553738chr12:113596917ENST00000446861-921565_672283777.0DomainPH
HgeneRASAL1chr12:113553738chr12:113596917ENST00000546530-1022301_511283807.0DomainRas-GAP
HgeneRASAL1chr12:113553738chr12:113596917ENST00000546530-1022565_672283807.0DomainPH
HgeneRASAL1chr12:113553738chr12:113596917ENST00000548055-921301_511283806.0DomainRas-GAP
HgeneRASAL1chr12:113553738chr12:113596917ENST00000548055-921565_672283806.0DomainPH
HgeneRASAL1chr12:113553739chr12:113596914ENST00000261729-1022301_511283805.0DomainRas-GAP
HgeneRASAL1chr12:113553739chr12:113596914ENST00000261729-1022565_672283805.0DomainPH
HgeneRASAL1chr12:113553739chr12:113596914ENST00000446861-921301_511283777.0DomainRas-GAP
HgeneRASAL1chr12:113553739chr12:113596914ENST00000446861-921565_672283777.0DomainPH
HgeneRASAL1chr12:113553739chr12:113596914ENST00000546530-1022301_511283807.0DomainRas-GAP
HgeneRASAL1chr12:113553739chr12:113596914ENST00000546530-1022565_672283807.0DomainPH
HgeneRASAL1chr12:113553739chr12:113596914ENST00000548055-921301_511283806.0DomainRas-GAP
HgeneRASAL1chr12:113553739chr12:113596914ENST00000548055-921565_672283806.0DomainPH
HgeneRASAL1chr12:113545890chr12:113616831ENST00000261729-1522674_710504805.0Zinc fingerBtk-type
HgeneRASAL1chr12:113545890chr12:113616831ENST00000446861-1421674_710504777.0Zinc fingerBtk-type
HgeneRASAL1chr12:113545890chr12:113616831ENST00000546530-1522674_710505807.0Zinc fingerBtk-type
HgeneRASAL1chr12:113545890chr12:113616831ENST00000548055-1421674_710504806.0Zinc fingerBtk-type
HgeneRASAL1chr12:113553738chr12:113596917ENST00000261729-1022674_710283805.0Zinc fingerBtk-type
HgeneRASAL1chr12:113553738chr12:113596917ENST00000446861-921674_710283777.0Zinc fingerBtk-type
HgeneRASAL1chr12:113553738chr12:113596917ENST00000546530-1022674_710283807.0Zinc fingerBtk-type
HgeneRASAL1chr12:113553738chr12:113596917ENST00000548055-921674_710283806.0Zinc fingerBtk-type
HgeneRASAL1chr12:113553739chr12:113596914ENST00000261729-1022674_710283805.0Zinc fingerBtk-type
HgeneRASAL1chr12:113553739chr12:113596914ENST00000446861-921674_710283777.0Zinc fingerBtk-type
HgeneRASAL1chr12:113553739chr12:113596914ENST00000546530-1022674_710283807.0Zinc fingerBtk-type
HgeneRASAL1chr12:113553739chr12:113596914ENST00000548055-921674_710283806.0Zinc fingerBtk-type
TgeneDDX54chr12:113545890chr12:113616831ENST00000306014320127_299188882.0DomainHelicase ATP-binding
TgeneDDX54chr12:113545890chr12:113616831ENST00000314045320127_299188883.0DomainHelicase ATP-binding
TgeneDDX54chr12:113553738chr12:113596917ENST000003060141820127_299804882.0DomainHelicase ATP-binding
TgeneDDX54chr12:113553738chr12:113596917ENST000003060141820326_473804882.0DomainHelicase C-terminal
TgeneDDX54chr12:113553738chr12:113596917ENST000003140451820127_299804883.0DomainHelicase ATP-binding
TgeneDDX54chr12:113553738chr12:113596917ENST000003140451820326_473804883.0DomainHelicase C-terminal
TgeneDDX54chr12:113553739chr12:113596914ENST000003060141820127_299804882.0DomainHelicase ATP-binding
TgeneDDX54chr12:113553739chr12:113596914ENST000003060141820326_473804882.0DomainHelicase C-terminal
TgeneDDX54chr12:113553739chr12:113596914ENST000003140451820127_299804883.0DomainHelicase ATP-binding
TgeneDDX54chr12:113553739chr12:113596914ENST000003140451820326_473804883.0DomainHelicase C-terminal
TgeneDDX54chr12:113545890chr12:113616831ENST0000030601432096_124188882.0MotifNote=Q motif
TgeneDDX54chr12:113545890chr12:113616831ENST0000031404532096_124188883.0MotifNote=Q motif
TgeneDDX54chr12:113553738chr12:113596917ENST000003060141820247_250804882.0MotifNote=DEAD box
TgeneDDX54chr12:113553738chr12:113596917ENST00000306014182096_124804882.0MotifNote=Q motif
TgeneDDX54chr12:113553738chr12:113596917ENST000003140451820247_250804883.0MotifNote=DEAD box
TgeneDDX54chr12:113553738chr12:113596917ENST00000314045182096_124804883.0MotifNote=Q motif
TgeneDDX54chr12:113553739chr12:113596914ENST000003060141820247_250804882.0MotifNote=DEAD box
TgeneDDX54chr12:113553739chr12:113596914ENST00000306014182096_124804882.0MotifNote=Q motif
TgeneDDX54chr12:113553739chr12:113596914ENST000003140451820247_250804883.0MotifNote=DEAD box
TgeneDDX54chr12:113553739chr12:113596914ENST00000314045182096_124804883.0MotifNote=Q motif
TgeneDDX54chr12:113545890chr12:113616831ENST00000306014320140_147188882.0Nucleotide bindingATP
TgeneDDX54chr12:113545890chr12:113616831ENST00000314045320140_147188883.0Nucleotide bindingATP
TgeneDDX54chr12:113553738chr12:113596917ENST000003060141820140_147804882.0Nucleotide bindingATP
TgeneDDX54chr12:113553738chr12:113596917ENST000003140451820140_147804883.0Nucleotide bindingATP
TgeneDDX54chr12:113553739chr12:113596914ENST000003060141820140_147804882.0Nucleotide bindingATP
TgeneDDX54chr12:113553739chr12:113596914ENST000003140451820140_147804883.0Nucleotide bindingATP


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Fusion Gene Sequence for RASAL1-DDX54


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RASAL1-DDX54


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneDDX54chr12:113545890chr12:113616831ENST00000306014320605_647188.0882.0nuclear receptors
TgeneDDX54chr12:113545890chr12:113616831ENST00000314045320605_647188.0883.0nuclear receptors


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneDDX54chr12:113553738chr12:113596917ENST000003060141820605_647804.3333333333334882.0nuclear receptors
TgeneDDX54chr12:113553738chr12:113596917ENST000003140451820605_647804.3333333333334883.0nuclear receptors
TgeneDDX54chr12:113553739chr12:113596914ENST000003060141820605_647804.3333333333334882.0nuclear receptors
TgeneDDX54chr12:113553739chr12:113596914ENST000003140451820605_647804.3333333333334883.0nuclear receptors


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RASAL1-DDX54


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RASAL1-DDX54


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource