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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:RASGRF1-HCN4 (FusionGDB2 ID:72452) |
Fusion Gene Summary for RASGRF1-HCN4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RASGRF1-HCN4 | Fusion gene ID: 72452 | Hgene | Tgene | Gene symbol | RASGRF1 | HCN4 | Gene ID | 5923 | 10021 |
| Gene name | Ras protein specific guanine nucleotide releasing factor 1 | hyperpolarization activated cyclic nucleotide gated potassium channel 4 | |
| Synonyms | CDC25|CDC25L|GNRP|GRF1|GRF55|H-GRF55|PP13187|ras-GRF1 | SSS2 | |
| Cytomap | 15q25.1 | 15q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras-specific guanine nucleotide-releasing factor 1Ras-specific guanine nucleotide-releasing factor, CDC25 homologRas-specific nucleotide exchange factor CDC25guanine nucleotide exchange factorguanine nucleotide-releasing factor 1guanine nucleotide-re | potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4hyperpolarization activated cyclic nucleotide-gated cation channel 4 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000419573, ENST00000558480, ENST00000394745, ENST00000560334, | ENST00000261917, | |
| Fusion gene scores | * DoF score | 15 X 9 X 3=405 | 1 X 1 X 1=1 |
| # samples | 15 | 1 | |
| ** MAII score | log2(15/405*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RASGRF1 [Title/Abstract] AND HCN4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | RASGRF1(79264208)-HCN4(73636149), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | RASGRF1-HCN4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. RASGRF1-HCN4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HCN4 | GO:0003254 | regulation of membrane depolarization | 12750403 |
| Tgene | HCN4 | GO:0006812 | cation transport | 12750403 |
| Tgene | HCN4 | GO:0071320 | cellular response to cAMP | 12750403|16407510|22748890 |
| Tgene | HCN4 | GO:0071321 | cellular response to cGMP | 22748890 |
| Tgene | HCN4 | GO:0071805 | potassium ion transmembrane transport | 16407510 |
| Tgene | HCN4 | GO:0098719 | sodium ion import across plasma membrane | 10228147 |
| Tgene | HCN4 | GO:1990573 | potassium ion import across plasma membrane | 10228147 |
| Fusion gene breakpoints across RASGRF1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across HCN4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-FX-A3TO-01A | RASGRF1 | chr15 | 79264208 | - | HCN4 | chr15 | 73636149 | - |
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Fusion Gene ORF analysis for RASGRF1-HCN4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000419573 | ENST00000261917 | RASGRF1 | chr15 | 79264208 | - | HCN4 | chr15 | 73636149 | - |
| Frame-shift | ENST00000558480 | ENST00000261917 | RASGRF1 | chr15 | 79264208 | - | HCN4 | chr15 | 73636149 | - |
| In-frame | ENST00000394745 | ENST00000261917 | RASGRF1 | chr15 | 79264208 | - | HCN4 | chr15 | 73636149 | - |
| intron-3CDS | ENST00000560334 | ENST00000261917 | RASGRF1 | chr15 | 79264208 | - | HCN4 | chr15 | 73636149 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000394745 | RASGRF1 | chr15 | 79264208 | - | ENST00000261917 | HCN4 | chr15 | 73636149 | - | 8004 | 2555 | 2568 | 5381 | 937 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000394745 | ENST00000261917 | RASGRF1 | chr15 | 79264208 | - | HCN4 | chr15 | 73636149 | - | 0.028073339 | 0.9719267 |
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Fusion Genomic Features for RASGRF1-HCN4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RASGRF1-HCN4 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:79264208/chr15:73636149) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RASGRF1 | chr15:79264208 | chr15:73636149 | ENST00000394745 | - | 13 | 14 | 204_229 | 459 | 490.0 | Domain | IQ |
| Hgene | RASGRF1 | chr15:79264208 | chr15:73636149 | ENST00000394745 | - | 13 | 14 | 22_129 | 459 | 490.0 | Domain | PH 1 |
| Hgene | RASGRF1 | chr15:79264208 | chr15:73636149 | ENST00000394745 | - | 13 | 14 | 240_426 | 459 | 490.0 | Domain | DH |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 924_1076 | 261 | 1204.0 | Compositional bias | Note=Pro-rich | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 465_486 | 261 | 1204.0 | Intramembrane | Pore-forming%3B Name%3DSegment H5 | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 659_662 | 261 | 1204.0 | Nucleotide binding | cAMP | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 669_670 | 261 | 1204.0 | Nucleotide binding | cAMP | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 710_713 | 261 | 1204.0 | Nucleotide binding | cAMP | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 288_293 | 261 | 1204.0 | Topological domain | Extracellular | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 315_340 | 261 | 1204.0 | Topological domain | Cytoplasmic | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 362_368 | 261 | 1204.0 | Topological domain | Extracellular | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 390_420 | 261 | 1204.0 | Topological domain | Cytoplasmic | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 442_464 | 261 | 1204.0 | Topological domain | Extracellular | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 487_496 | 261 | 1204.0 | Topological domain | Extracellular | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 518_1203 | 261 | 1204.0 | Topological domain | Cytoplasmic | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 267_287 | 261 | 1204.0 | Transmembrane | Helical%3B Name%3DSegment S1 | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 294_314 | 261 | 1204.0 | Transmembrane | Helical%3B Name%3DSegment S2 | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 341_361 | 261 | 1204.0 | Transmembrane | Helical%3B Name%3DSegment S3 | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 369_389 | 261 | 1204.0 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 421_441 | 261 | 1204.0 | Transmembrane | Helical%3B Name%3DSegment S5 | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 497_517 | 261 | 1204.0 | Transmembrane | Helical%3B Name%3DSegment S6 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RASGRF1 | chr15:79264208 | chr15:73636149 | ENST00000394745 | - | 13 | 14 | 1038_1270 | 459 | 490.0 | Domain | Ras-GEF |
| Hgene | RASGRF1 | chr15:79264208 | chr15:73636149 | ENST00000394745 | - | 13 | 14 | 467_584 | 459 | 490.0 | Domain | PH 2 |
| Hgene | RASGRF1 | chr15:79264208 | chr15:73636149 | ENST00000394745 | - | 13 | 14 | 644_761 | 459 | 490.0 | Domain | N-terminal Ras-GEF |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 209_260 | 261 | 1204.0 | Region | Involved in subunit assembly | |
| Tgene | HCN4 | chr15:79264208 | chr15:73636149 | ENST00000261917 | 0 | 8 | 1_266 | 261 | 1204.0 | Topological domain | Cytoplasmic |
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Fusion Gene Sequence for RASGRF1-HCN4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >72452_72452_1_RASGRF1-HCN4_RASGRF1_chr15_79264208_ENST00000394745_HCN4_chr15_73636149_ENST00000261917_length(transcript)=8004nt_BP=2555nt GGAGCCCTTTTTGGCCTACTTGGGGTGAGTCAACATAAGGAGTGCAGGCCACCTTAGCCTTTGCTTCTCAAAAGTCATGGGGCAATGAAG GACTTGGCCAAGGCTGTCCAGCAGTAGGCCAAGTTCAGGGATTGGCTCAGGCCCCTAATGGACTTCACTGCATCCAGGAATGGTAGGTGA TTATCTTTTCCGAGAGGCCACCTACCCAGATCCCAGTTGTGGACAGCCCATCCCAGCCCTCAGAGGCTCAGAGGCTCTCTGAGTGCCCTG CCCCAAAACACCCTAGGCAAGACATTATGCCAGAGCCTCAGCTCTAGGGCTGCCTGGAGCAGAGCTCCTGAATCACACTGGCTCCCCAGG GCTCCCCAGGAACCTCACCATTCCTCCCCCAATCCACACCTCTGCTGCCAGAGCAACGCAACGACCCAGAATACACCCGTTCCCTCTTCT GTTCCCTCCTCCTGCCCCCACCTCAGGCCTCACTGGGGCAGGGTACATCTTGCCTCTCTGCCCTGAACTTCTGAAACCTCAATGATCAGA TTCCCAGGGCTCTGAGAAAACAGAAGCAAACATCCCATCCAGGATGGATTTACCCCCTAAAAGTCACTGAGATCATTCCCAGGGGCCCAG CAGACAGTGTCCTTCCTTTCCCAGCAGCAGTGCCCTGCAGAACAAAGAGGCTGGTTCAGAGCCAGCTCTCAGCCCTATGGCCTTGGCTGA GTCCCTTAACCTTTCTGAGACTCAGTTTCCTACCTGTGACATTCCTGCAGTTATCCTGTAGGAATAAGAGTGCCTACGTCCTGGGGCAAC AGTGAGGGTTAAAAGATCAATCCTATCCTGTGTGCAACGTGGAGCAGACAGCCTCGATGAGACAAGCTATGGTTTGCAATGTTCTGGATG TATAACCTGTTTCCAGCCTGGCCTGAGGTGGAACCCTGTCATGAGGATGGTCGCTGGAGCTCCTGTTTGCCAGTGGCCAGAACAATAAGC TCCTGTACGGTGAACCCCCCAAGTCCCCGCGCGCCACCCGCAAGTTCTCCTCGCCGCCACCTCTGTCCATCACCAAGACATCGTCACCGA GCCGCCGGCGGAAGCTCTCCCTGAACATCCCCATCATCACTGGCGGCAAGGCCCTGGACCTGGCCGCCCTCAGCTGCAACTCCAATGGCT ACACCAGCATGTACTCGGCCATGTCACCCTTCAGCAAGGCCACGCTGGACACCAGCAAGCTCTATGTGTCCAGCAGCTTCACCAACAAGA TTCCAGATGAGGGCGATACGACCCCTGAGAAGCCCGAAGACCCTTCAGCGCTCAGCAAGCAGAGCTCAGAAGTCTCCATGAGAGAGGAGT CAGATATTGATCAAAACCAGAGTGATGATGGTGATACTGAAACATCACCAACTAAATCTCCAACAACACCCAAATCAGTCAAAAACAAAA ATTCTTCAGAGTTCCCACTCTTTTCCTATAACAATGGAGTCGTCATGACCTCCTGTCGTGAACTGGACAATAACCGCAGTGCCTTGTCGG CCGCCTCTGCCTTTGCCATAGCAACCGCCGGGGCCAACGAGGGCACCCCAAACAAGGAGAAGTACCGGAGGATGTCCTTAGCCAGTGCAG GGTTTCCCCCAGACCAGAGGAATGGAGACAAGGAGTTTGTGATCCGCAGAGCAGCCACCAATCGTGTCTTGAACGTGCTCCGCCACTGGG TGTCCAAGCACTCTCAGGACTTTGAGACCAACGATGAGCTCAAATGCAAGGTGATCGGCTTCCTGGAAGAAGTCATGCACGACCCGGAGC TCCTGACCCAGGAGCGGAAGGCTGCAGCCAACATCATCAGGACTCTGACCCAGGAGGACCCAGGTGACAACCAGATCACGCTGGAGGAGA TCACGCAGATGGCTGAAGGCGTGAAGGCTGAGCCCTTTGAAAACCACTCAGCCCTGGAGATCGCGGAGCAGCTGACCCTGCTAGATCACC TCGTCTTCAAGAAGATTCCTTATGAGGAGTTCTTCGGACAAGGATGGATGAAACTGGAAAAGAATGAAAGGACCCCTTATATCATGAAAA CCACTAAGCACTTCAATGACATCAGTAACTTGATTGCTTCAGAAATCATCCGCAATGAGGACATCAACGCCAGGGTGAGCGCCATCGAGA AGTGGGTGGCCGTAGCTGACATATGCCGCTGCCTCCACAACTACAATGCCGTACTGGAGATCACCTCGTCCATGAACCGCAGTGCAATCT TCCGGCTCAAAAAGACGTGGCTCAAAGTCTCTAAGCAGACTAAAGCTTTGATTGATAAGCTCCAAAAGCTTGTGTCATCTGAGGGCAGAT TTAAGAATCTCAGAGAAGCTCTGAAAAATTGTGACCCACCCTGTGTCCCTTACCTGGGGATGTACCTCACCGACCTGGCCTTCATCGAGG AGGGGACGCCCAATTACACGGAAGACGGCCTGGTCAACTTCTCCAAGATGAGGATGATATCCCATATTATCCGAGAGATTCGCCAGTTTC AACAAACTGCCTACAAAATAGAGCACCAAGCAAAGATTTTACTGGGACCTGACCATGCTGCTGCTGATGGTGGGAAACCTGATTATCATT CCTGTGGGCATCACCTTCTTCAAGGATGAGAACACCACACCCTGGATTGTCTTCAATGTGGTGTCAGACACATTCTTCCTCATCGACTTG GTCCTCAACTTCCGCACAGGGATCGTGGTGGAGGACAACACAGAGATCATCCTGGACCCGCAGCGGATTAAAATGAAGTACCTGAAAAGC TGGTTCATGGTAGATTTCATTTCCTCCATCCCCGTGGACTACATCTTCCTCATTGTGGAGACACGCATCGACTCGGAGGTCTACAAGACT GCCCGGGCCCTGCGCATTGTCCGCTTCACGAAGATCCTCAGCCTCTTACGCCTGTTACGCCTCTCCCGCCTCATTCGATATATTCACCAG TGGGAAGAGATCTTCCACATGACCTACGACCTGGCCAGCGCCGTGGTGCGCATCGTGAACCTCATCGGCATGATGCTCCTGCTCTGCCAC TGGGACGGCTGCCTGCAGTTCCTGGTACCCATGCTACAGGACTTCCCTGACGACTGCTGGGTGTCCATCAACAACATGGTGAACAACTCC TGGGGGAAGCAGTACTCCTACGCGCTCTTCAAGGCCATGAGCCACATGCTGTGCATCGGCTACGGGCGGCAGGCGCCCGTGGGCATGTCC GACGTCTGGCTCACCATGCTCAGCATGATCGTGGGTGCCACCTGCTACGCCATGTTCATTGGCCACGCCACTGCCCTCATCCAGTCCCTG GACTCCTCCCGGCGCCAGTACCAGGAAAAGTACAAGCAGGTGGAGCAGTACATGTCCTTTCACAAGCTCCCGCCCGACACCCGGCAGCGC ATCCACGACTACTACGAGCACCGCTACCAGGGCAAGATGTTCGACGAGGAGAGCATCCTGGGCGAGCTAAGCGAGCCCCTGCGGGAGGAG ATCATCAACTTTAACTGTCGGAAGCTGGTGGCCTCCATGCCACTGTTTGCCAATGCGGACCCCAACTTCGTGACGTCCATGCTGACCAAG CTGCGTTTCGAGGTCTTCCAGCCTGGGGACTACATCATCCGGGAAGGCACCATTGGCAAGAAGATGTACTTCATCCAGCATGGCGTGGTC AGCGTGCTCACCAAGGGCAACAAGGAGACCAAGCTGGCCGACGGCTCCTACTTTGGAGAGATCTGCCTGCTGACCCGGGGCCGGCGCACA GCCAGCGTGAGGGCCGACACCTACTGCCGCCTCTACTCGCTGAGCGTGGACAACTTCAATGAGGTGCTGGAGGAGTACCCCATGATGCGA AGGGCCTTCGAGACCGTGGCGCTGGACCGCCTGGACCGCATTGGCAAGAAGAACTCCATCCTCCTCCACAAAGTCCAGCACGACCTCAAC TCCGGCGTCTTCAACTACCAGGAGAATGAGATCATCCAGCAGATTGTGCAGCATGACCGGGAGATGGCCCACTGCGCGCACCGCGTCCAG GCTGCTGCCTCTGCCACCCCAACCCCCACGCCCGTCATCTGGACCCCGCTGATCCAGGCACCACTGCAGGCTGCCGCTGCCACCACTTCT GTGGCCATAGCCCTCACCCACCACCCTCGCCTGCCTGCTGCCATCTTCCGCCCTCCCCCAGGATCTGGGCTGGGCAACCTCGGTGCCGGG CAGACGCCAAGGCACCTGAAACGGCTGCAGTCCCTGATCCCTTCTGCGCTGGGCTCCGCCTCGCCCGCCAGCAGCCCGTCCCAGGTGGAC ACACCGTCTTCATCCTCCTTCCACATCCAACAGCTGGCTGGATTCTCTGCCCCCGCTGGACTGAGCCCACTCCTGCCCTCATCCAGCTCC TCCCCACCCCCCGGGGCCTGTGGCTCCCCCTCGGCTCCCACACCATCAGCTGGCGTAGCCGCCACCACCATAGCCGGGTTTGGCCACTTC CACAAGGCGCTGGGTGGCTCCCTGTCCTCCTCCGACTCTCCCCTGCTCACCCCGCTGCAGCCAGGCGCCCGCTCCCCGCAGGCTGCCCAG CCATCTCCCGCGCCACCCGGGGCCCGGGGAGGCCTGGGACTCCCGGAGCACTTCCTGCCACCCCCACCCTCATCCAGATCCCCGTCATCT AGCCCCGGGCAGCTGGGCCAGCCTCCCGGGGAGTTGTCCCTAGGTCTGGCCACTGGCCCACTGAGCACGCCAGAGACACCCCCACGGCAG CCTGAGCCGCCGTCCCTTGTGGCAGGGGCCTCTGGGGGGGCTTCCCCTGTAGGCTTTACTCCCCGAGGAGGTCTCAGCCCCCCTGGCCAC AGCCCAGGCCCCCCAAGAACCTTCCCGAGTGCCCCGCCCCGGGCCTCTGGCTCCCACGGATCCTTGCTCCTGCCACCTGCATCCAGCCCC CCACCACCCCAGGTCCCCCAGCGCCGGGGCACACCCCCGCTCACCCCCGGCCGCCTCACCCAGGACCTCAAGCTCATCTCCGCGTCTCAG CCAGCCCTGCCTCAGGACGGGGCGCAGACTCTCCGCAGAGCCTCCCCGCACTCCTCAGGGGAGTCCATGGCTGCCTTCCCGCTCTTCCCC AGGGCTGGGGGTGGCAGCGGGGGCAGTGGGAGCAGCGGGGGCCTCGGTCCCCCTGGGAGGCCCTATGGTGCCATCCCCGGCCAGCACGTC ACTCTGCCTCGGAAGACATCCTCAGGTTCTTTGCCACCCCCTCTGTCTTTGTTTGGGGCAAGAGCCACCTCTTCTGGGGGGCCCCCTCTG ACTGCTGGACCCCAGAGGGAACCTGGGGCCAGGCCTGAGCCAGTGCGCTCCAAACTGCCATCCAATCTATGAGCTGGGCCCTTCCTTCCC TCTTCTTTCTTCTTTTCTCTCCCTTCCTTCTTCCTTCAGGTTTAACTGTGATTAGGAGATATACCAATAACAGTAATAATTATTTAAAAA ACCACACACACCAGAAAAACAAAAGACAGCAGAAAATAACCAGGTATTCTTAGAGCTATAGATTTTTGGTCACTTGCTTTTATAGACTAT TTTAATACTCAGCACTAGAGGGAGGGAGGGGGAGGGAGGAGGGAGCAGGCAGGTCCCAAATGCAAAAGCCAGAGAAAGGCAGATGGGGTC TCCGGGGCTGGGCAGGGGTGGGAGTGGCCAGTGTTGGCGGTTCTTAGAGCAGATGTGTCATTGTGTTCATTTAGAGAAACAGCTGCCATC AGCCCGTTAGCTGTAACTTGGAGCTCCACTCTGCCCCCAGAAAGGGGCTGCCCTGGGGTGTGCCCTGGGGAGCCTCAGAAGCCTGCGACC TTGGGAGAAAAGGGCCAGGGCCCTGAGGGCCTAGCATTTTTTCTACTGTAAACGTAGCAAGATCTGTATATGAATATGTATATGTATATG TATGTAAGATGTGTATATGTATAGCTATGTAGCGCTCTGTAGAGCCATGTAGATAGCCACTCACATGTGCGCACACGTGTGCGGTCTAGT TTAATCCCATGTTGACAGGATGCCCAGGTCACCTTACACCCAGCAACCCGCCTTGGCCCACAGGCTGTGCACTGCATGGTCTAGGGACGT TCTCTCTCCAGTCCTCAGGGAAGAGGACCCCAGGACTTCGCAGCAGGCCCCCTCTCTCCCCATCTCTGGTCTCAAAGCCAGTCCCAGCCT GACCTCTCACCACACGGAAGTGGAAGACTCCCCTTTCCTAGGGCCTCAAGCACACACCGCCACCTCTGGGGCCGTCAGTTTGCCCATCTG TACAGTGGGAGGTGAGCGGAACTTCTGTTTATTGAGTCTGCTCTGTGCCAAGCACTGGTTTCGCACTTTACACACATTAACTCCTTCAGT TTCACAAAGACCATGGGGTGGGTACTTTGATTCTCCCCATTTAGCAGAGGAAGAAACAGTTTTGGGTAATTTTTCCAGAATCATGTAACT AGGAGTGGCAGAGTGGGGACTGATTTGAGGTTCGAGTCCACGCCTCCTTGAGGCCCAAGTCTGTGTTCCTTCCATCAGAAAACTGTGTTG AGGGGGGCTGAGGTAGATGGTCCCCAAGCATGGTACAGAAGGAAGACACCAGATTTTGGCAGCAGTCAGGCCTGGGTTTGAATCCCAGCC CTGCCACTTCTTAGCTGTATGATCTTGGGCAAGTTATCTGACCTTTCTGTCACCTCATTTGTAAAATGGGAATAATTATGGTACTGCCTC ACAAGGACCTATGAGGACCAGATGAGAAAAATCTATATGTGAAATGCCCAGCCCAGCGCCTGGCACATACCATGGTAGGTGCTCAATAAA AAATCACATTTCTTCTGCCCCTCATATGCCCAGCCTATTGCTCCAGCAAACTATGTGAGAGCCCAGGGAGCTTTGGCTGAGGGCTCCAAG ACTTAAAATCTCAGGACTCAGGAGGTGGCTGGGCCTCCCTAAGGGCCCAAGGAAGGTGTGTGGCCAGAGGTGGGTGGGAGCCAGGCCTTG AGAAGTGGGAAGACTTCAACAGGGAGAGAGGGAGGGAATGGTGGGTGGGATGGAGTGTATGGTGGGGAGATTCCTGAGGTGGATGTGGAG TGGTGGATCAGGGCTTTGGGAGGGGATCCCCAGGCTGAGGGGTCAGAGGGACGGCCTTGGGTGATAGGGTAAGGGATTGTCTGGGCTTAG TCCTGGCAACTAGGAGCCATAAGCAGGTTCCAGATTGCGGGAACGAGAAAGCAGCTCAGATGCCTTTGGAGGCACCATCCTCCCTCCTCC CAGATGGGATCTTGCCAGAGCCAAGGTCAGGGGTCTGCCCCTGCCTATAGGGCCAGAGCAGGTATGGCTGCAATCCCCAAGTAATGAGAA GGGCTGGTCCCACATTATCCATCCAGAACCTTCCATGCTCCAAGCCAGAATGTTGGCAAGATCGGGTTTTGCCTTGAGCTATCCTGGGAT GTGAGACAAACCGATTTCTCCATAGATGGGCTGCAGGGAGTGGGAGGCAGTACTCCAGGAGAGAAGTGGGTGAAGGTTCCTGGGATCTTA GGTAAAGACTAGACGCCGCCTAGTACTGGTCTCTACTGTGCTGGCTCAGGAGTTCTGAGAACTGGAAGGACTTAGCCTCAACCTGAGTTC TGCACACACCCCTTCCCCTTAAGGAAGGCAGCTCTGAGAGGCAGCAGGACTTGATCCAAACCCACAGTCTTGTCCTGGAGGCAGCAGGGG TGAAGGTGGAGGGTCCAGGGCCATGAGGAGCCCCCTTGCCATCAGAGCCTGGCCTAACCACCCTCTTCTCTACTTACACACACATGCATT TTATAATAGCTCTGACCCAACCTGGCCACTCTGCAGAGACTGGGACAGACAGGTGCAGGCAATGGGCCCTCCCACACCCAGTCACCTACA >72452_72452_1_RASGRF1-HCN4_RASGRF1_chr15_79264208_ENST00000394745_HCN4_chr15_73636149_ENST00000261917_length(amino acids)=937AA_BP= MTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIF LIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFP DDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQ YMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREG TIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGK KNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIF RPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPS AGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGL ATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTP GRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RASGRF1-HCN4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RASGRF1-HCN4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RASGRF1-HCN4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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