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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RASSF3-ITGA7 (FusionGDB2 ID:72492)

Fusion Gene Summary for RASSF3-ITGA7

check button Fusion gene summary
Fusion gene informationFusion gene name: RASSF3-ITGA7
Fusion gene ID: 72492
HgeneTgene
Gene symbol

RASSF3

ITGA7

Gene ID

283349

3679

Gene nameRas association domain family member 3integrin subunit alpha 7
SynonymsRASSF5-
Cytomap

12q14.2

12q13.2

Type of geneprotein-codingprotein-coding
Descriptionras association domain-containing protein 3Ras association (RalGDS/AF-6) domain family 3Ras association (RalGDS/AF-6) domain family member 3integrin alpha-7integrin alpha 7 chain
Modification date2020032720200328
UniProtAcc.

Q13683

Ensembl transtripts involved in fusion geneENST00000540088, ENST00000336061, 
ENST00000542104, 		ENST00000257879, 
ENST00000257880, ENST00000347027, 
ENST00000394229, ENST00000394230, 
ENST00000452168, ENST00000553804, 
ENST00000555728, 
Fusion gene scores* DoF score18 X 7 X 12=15125 X 3 X 5=75
# samples 185
** MAII scorelog2(18/1512*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RASSF3 [Title/Abstract] AND ITGA7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRASSF3(65004523)-ITGA7(56079072), # samples:3
Anticipated loss of major functional domain due to fusion event.RASSF3-ITGA7 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
RASSF3-ITGA7 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RASSF3-ITGA7 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RASSF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITGA7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-GN-A26D-06ARASSF3chr12

65004523

-ITGA7chr12

56079072

-
ChimerDB4SKCMTCGA-GN-A26D-06ARASSF3chr12

65004523

+ITGA7chr12

56079072

-


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Fusion Gene ORF analysis for RASSF3-ITGA7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000540088ENST00000257879RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000257880RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000347027RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000394229RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000394230RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000452168RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000553804RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000555728RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000336061ENST00000257879RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000336061ENST00000257880RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000336061ENST00000394229RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000336061ENST00000394230RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000336061ENST00000555728RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000542104ENST00000257879RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000542104ENST00000257880RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000542104ENST00000394229RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000542104ENST00000394230RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000542104ENST00000555728RASSF3chr12

65004523

+ITGA7chr12

56079072

-
In-frameENST00000336061ENST00000347027RASSF3chr12

65004523

+ITGA7chr12

56079072

-
In-frameENST00000336061ENST00000452168RASSF3chr12

65004523

+ITGA7chr12

56079072

-
In-frameENST00000336061ENST00000553804RASSF3chr12

65004523

+ITGA7chr12

56079072

-
In-frameENST00000542104ENST00000347027RASSF3chr12

65004523

+ITGA7chr12

56079072

-
In-frameENST00000542104ENST00000452168RASSF3chr12

65004523

+ITGA7chr12

56079072

-
In-frameENST00000542104ENST00000553804RASSF3chr12

65004523

+ITGA7chr12

56079072

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336061RASSF3chr1265004523+ENST00000553804ITGA7chr1256079072-8751546421214
ENST00000336061RASSF3chr1265004523+ENST00000347027ITGA7chr1256079072-8711546421214
ENST00000336061RASSF3chr1265004523+ENST00000452168ITGA7chr1256079072-8711546421214
ENST00000542104RASSF3chr1265004523+ENST00000553804ITGA7chr1256079072-9522317190240
ENST00000542104RASSF3chr1265004523+ENST00000347027ITGA7chr1256079072-9482317190240
ENST00000542104RASSF3chr1265004523+ENST00000452168ITGA7chr1256079072-9482317190240

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336061ENST00000553804RASSF3chr1265004523+ITGA7chr1256079072-0.099831680.9001683
ENST00000336061ENST00000347027RASSF3chr1265004523+ITGA7chr1256079072-0.1058051660.89419484
ENST00000336061ENST00000452168RASSF3chr1265004523+ITGA7chr1256079072-0.1058051660.89419484
ENST00000542104ENST00000553804RASSF3chr1265004523+ITGA7chr1256079072-0.179550630.82044935
ENST00000542104ENST00000347027RASSF3chr1265004523+ITGA7chr1256079072-0.180610220.8193898
ENST00000542104ENST00000452168RASSF3chr1265004523+ITGA7chr1256079072-0.180610220.8193898

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Fusion Genomic Features for RASSF3-ITGA7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RASSF3-ITGA7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:65004523/chr12:56079072)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ITGA7

Q13683

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. {ECO:0000250, ECO:0000269|PubMed:10694445, ECO:0000269|PubMed:17641293, ECO:0000269|PubMed:9307969}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneITGA7chr12:65004523chr12:56079072ENST0000025787923251107_111110611138.0MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST0000045216823251107_11119681045.0MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST0000055380423251107_111110651142.0MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST0000055572824261107_111111051182.0MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST0000025787923251157_117610611138.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST0000025788025271157_117611421163.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST0000045216823251157_11769681045.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST0000055380423251157_117610651142.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST0000055572824261157_117611051182.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST0000025787923251157_116010611138.0RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST0000025787923251165_116810611138.0RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST0000025787923251173_117610611138.0RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST0000025788025271157_116011421163.0RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST0000025788025271165_116811421163.0RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST0000025788025271173_117611421163.0RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST0000045216823251157_11609681045.0RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST0000045216823251165_11689681045.0RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST0000045216823251173_11769681045.0RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST0000055380423251157_116010651142.0RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST0000055380423251165_116810651142.0RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST0000055380423251173_117610651142.0RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST0000055572824261157_116011051182.0RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST0000055572824261165_116811051182.0RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST0000055572824261173_117611051182.0RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST0000025787923251104_118110611138.0Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST0000045216823251104_11819681045.0Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST0000055380423251104_118110651142.0Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST0000055572824261104_118111051182.0Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST0000025787923251083_110310611138.0TransmembraneHelical
TgeneITGA7chr12:65004523chr12:56079072ENST0000045216823251083_11039681045.0TransmembraneHelical
TgeneITGA7chr12:65004523chr12:56079072ENST0000055380423251083_110310651142.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRASSF3chr12:65004523chr12:56079072ENST00000336061+26187_23437239.0DomainSARAH
HgeneRASSF3chr12:65004523chr12:56079072ENST00000336061+2679_18637239.0DomainRas-associating
HgeneRASSF3chr12:65004523chr12:56079072ENST00000542104+15187_23437239.0DomainSARAH
HgeneRASSF3chr12:65004523chr12:56079072ENST00000542104+1579_18637239.0DomainRas-associating
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325372_38010611138.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325434_44210611138.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325492_50010611138.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527372_38011421163.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527434_44211421163.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527492_50011421163.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325372_3809681045.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325434_4429681045.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325492_5009681045.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325372_38010651142.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325434_44210651142.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325492_50010651142.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426372_38011051182.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426434_44211051182.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426492_50011051182.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325953_95810611138.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527953_95811421163.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325953_9589681045.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325953_95810651142.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426953_95811051182.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST0000025788025271107_111111421163.0MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325110_17510611138.0RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325185_23810611138.0RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325292_34910611138.0RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325350_41110611138.0RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879232535_10310611138.0RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325412_46710611138.0RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325471_53010611138.0RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527110_17511421163.0RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527185_23811421163.0RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527292_34911421163.0RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527350_41111421163.0RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880252735_10311421163.0RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527412_46711421163.0RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527471_53011421163.0RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325110_1759681045.0RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325185_2389681045.0RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325292_3499681045.0RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325350_4119681045.0RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168232535_1039681045.0RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325412_4679681045.0RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325471_5309681045.0RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325110_17510651142.0RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325185_23810651142.0RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325292_34910651142.0RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325350_41110651142.0RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804232535_10310651142.0RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325412_46710651142.0RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325471_53010651142.0RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426110_17511051182.0RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426185_23811051182.0RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426292_34911051182.0RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426350_41111051182.0RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728242635_10311051182.0RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426412_46711051182.0RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426471_53011051182.0RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879232534_108210611138.0Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST0000025788025271104_118111421163.0Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880252734_108211421163.0Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168232534_10829681045.0Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804232534_108210651142.0Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728242634_108211051182.0Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST0000025788025271083_110311421163.0TransmembraneHelical
TgeneITGA7chr12:65004523chr12:56079072ENST0000055572824261083_110311051182.0TransmembraneHelical


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Fusion Gene Sequence for RASSF3-ITGA7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72492_72492_1_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000336061_ITGA7_chr12_56079072_ENST00000347027_length(transcript)=871nt_BP=154nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTT
CTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCA
CCCCGAGGCCACCGTGCCCCAGTACCATGCGGTGAAGATTCCTCGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCT
GAGGAACAACTGGGGCAGCCCCCGGCGGGAGGGCCCGGATGCACACCCCATCCTGGCTGCTGACGGGCATCCCGAGCTGGGCCCCGATGG
GCATCCAGGGCCAGGCACCGCCTAGGTTCCCATGTCCCAGCCTGGCCTGTGGCTGCCCTCCATCCCTTCCCCAGAGATGGCTCCTTGGGA
TGAAGAGGGTAGAGTGGGCTGCTGGTGTCGCATCAAGATTTGGCAGGATCGGCTTCCTCAGGGGCACAGACCTCTCCCACCCACAAGAAC
TCCTCCCACCCAACTTCCCCTTAGAGTGCTGTGAGATGAGAGTGGGTAAATCAGGGACAGGGCCATGGGGTAGGGTGAGAAGGGCAGGGG
TGTCCTGATGCAAAGGTGGGGAGAAGGGATCCTAATCCCTTCCTCTCCCATTCACCCTGTGTAACAGGACCCCAAGGACCTGCCTCCCCG
GAAGTGCCTTAACCTAGAGGGTCGGGGAGGAGGTTGTGTCACTGACTCAGGCTGCTCCTTCTCTAGTTTCCCCTCTCATCTGACCTTAGT

>72492_72492_1_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000336061_ITGA7_chr12_56079072_ENST00000347027_length(amino acids)=214AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLAGAGLALGRSPEEGG

--------------------------------------------------------------
>72492_72492_2_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000336061_ITGA7_chr12_56079072_ENST00000452168_length(transcript)=871nt_BP=154nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTT
CTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCA
CCCCGAGGCCACCGTGCCCCAGTACCATGCGGTGAAGATTCCTCGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCT
GAGGAACAACTGGGGCAGCCCCCGGCGGGAGGGCCCGGATGCACACCCCATCCTGGCTGCTGACGGGCATCCCGAGCTGGGCCCCGATGG
GCATCCAGGGCCAGGCACCGCCTAGGTTCCCATGTCCCAGCCTGGCCTGTGGCTGCCCTCCATCCCTTCCCCAGAGATGGCTCCTTGGGA
TGAAGAGGGTAGAGTGGGCTGCTGGTGTCGCATCAAGATTTGGCAGGATCGGCTTCCTCAGGGGCACAGACCTCTCCCACCCACAAGAAC
TCCTCCCACCCAACTTCCCCTTAGAGTGCTGTGAGATGAGAGTGGGTAAATCAGGGACAGGGCCATGGGGTAGGGTGAGAAGGGCAGGGG
TGTCCTGATGCAAAGGTGGGGAGAAGGGATCCTAATCCCTTCCTCTCCCATTCACCCTGTGTAACAGGACCCCAAGGACCTGCCTCCCCG
GAAGTGCCTTAACCTAGAGGGTCGGGGAGGAGGTTGTGTCACTGACTCAGGCTGCTCCTTCTCTAGTTTCCCCTCTCATCTGACCTTAGT

>72492_72492_2_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000336061_ITGA7_chr12_56079072_ENST00000452168_length(amino acids)=214AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLAGAGLALGRSPEEGG

--------------------------------------------------------------
>72492_72492_3_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000336061_ITGA7_chr12_56079072_ENST00000553804_length(transcript)=875nt_BP=154nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTT
CTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCA
CCCCGAGGCCACCGTGCCCCAGTACCATGCGGTGAAGATTCCTCGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCT
GAGGAACAACTGGGGCAGCCCCCGGCGGGAGGGCCCGGATGCACACCCCATCCTGGCTGCTGACGGGCATCCCGAGCTGGGCCCCGATGG
GCATCCAGGGCCAGGCACCGCCTAGGTTCCCATGTCCCAGCCTGGCCTGTGGCTGCCCTCCATCCCTTCCCCAGAGATGGCTCCTTGGGA
TGAAGAGGGTAGAGTGGGCTGCTGGTGTCGCATCAAGATTTGGCAGGATCGGCTTCCTCAGGGGCACAGACCTCTCCCACCCACAAGAAC
TCCTCCCACCCAACTTCCCCTTAGAGTGCTGTGAGATGAGAGTGGGTAAATCAGGGACAGGGCCATGGGGTAGGGTGAGAAGGGCAGGGG
TGTCCTGATGCAAAGGTGGGGAGAAGGGATCCTAATCCCTTCCTCTCCCATTCACCCTGTGTAACAGGACCCCAAGGACCTGCCTCCCCG
GAAGTGCCTTAACCTAGAGGGTCGGGGAGGAGGTTGTGTCACTGACTCAGGCTGCTCCTTCTCTAGTTTCCCCTCTCATCTGACCTTAGT

>72492_72492_3_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000336061_ITGA7_chr12_56079072_ENST00000553804_length(amino acids)=214AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLAGAGLALGRSPEEGG

--------------------------------------------------------------
>72492_72492_4_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000542104_ITGA7_chr12_56079072_ENST00000347027_length(transcript)=948nt_BP=231nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGCCGGGAACCTCGCGGGGCTGGCGGGCGCCGCACCCCCTCCCTGGCCGCCTGCGCCCCGGGG
AGGCCGCCCGCGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGG
ACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCACCCCGAGGCCACC
GTGCCCCAGTACCATGCGGTGAAGATTCCTCGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCTGAGGAACAACTGG
GGCAGCCCCCGGCGGGAGGGCCCGGATGCACACCCCATCCTGGCTGCTGACGGGCATCCCGAGCTGGGCCCCGATGGGCATCCAGGGCCA
GGCACCGCCTAGGTTCCCATGTCCCAGCCTGGCCTGTGGCTGCCCTCCATCCCTTCCCCAGAGATGGCTCCTTGGGATGAAGAGGGTAGA
GTGGGCTGCTGGTGTCGCATCAAGATTTGGCAGGATCGGCTTCCTCAGGGGCACAGACCTCTCCCACCCACAAGAACTCCTCCCACCCAA
CTTCCCCTTAGAGTGCTGTGAGATGAGAGTGGGTAAATCAGGGACAGGGCCATGGGGTAGGGTGAGAAGGGCAGGGGTGTCCTGATGCAA
AGGTGGGGAGAAGGGATCCTAATCCCTTCCTCTCCCATTCACCCTGTGTAACAGGACCCCAAGGACCTGCCTCCCCGGAAGTGCCTTAAC
CTAGAGGGTCGGGGAGGAGGTTGTGTCACTGACTCAGGCTGCTCCTTCTCTAGTTTCCCCTCTCATCTGACCTTAGTTTGCTGCCATCAG

>72492_72492_4_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000542104_ITGA7_chr12_56079072_ENST00000347027_length(amino acids)=240AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLAGAGLALGRSPEEGG

--------------------------------------------------------------
>72492_72492_5_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000542104_ITGA7_chr12_56079072_ENST00000452168_length(transcript)=948nt_BP=231nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGCCGGGAACCTCGCGGGGCTGGCGGGCGCCGCACCCCCTCCCTGGCCGCCTGCGCCCCGGGG
AGGCCGCCCGCGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGG
ACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCACCCCGAGGCCACC
GTGCCCCAGTACCATGCGGTGAAGATTCCTCGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCTGAGGAACAACTGG
GGCAGCCCCCGGCGGGAGGGCCCGGATGCACACCCCATCCTGGCTGCTGACGGGCATCCCGAGCTGGGCCCCGATGGGCATCCAGGGCCA
GGCACCGCCTAGGTTCCCATGTCCCAGCCTGGCCTGTGGCTGCCCTCCATCCCTTCCCCAGAGATGGCTCCTTGGGATGAAGAGGGTAGA
GTGGGCTGCTGGTGTCGCATCAAGATTTGGCAGGATCGGCTTCCTCAGGGGCACAGACCTCTCCCACCCACAAGAACTCCTCCCACCCAA
CTTCCCCTTAGAGTGCTGTGAGATGAGAGTGGGTAAATCAGGGACAGGGCCATGGGGTAGGGTGAGAAGGGCAGGGGTGTCCTGATGCAA
AGGTGGGGAGAAGGGATCCTAATCCCTTCCTCTCCCATTCACCCTGTGTAACAGGACCCCAAGGACCTGCCTCCCCGGAAGTGCCTTAAC
CTAGAGGGTCGGGGAGGAGGTTGTGTCACTGACTCAGGCTGCTCCTTCTCTAGTTTCCCCTCTCATCTGACCTTAGTTTGCTGCCATCAG

>72492_72492_5_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000542104_ITGA7_chr12_56079072_ENST00000452168_length(amino acids)=240AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLAGAGLALGRSPEEGG

--------------------------------------------------------------
>72492_72492_6_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000542104_ITGA7_chr12_56079072_ENST00000553804_length(transcript)=952nt_BP=231nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGCCGGGAACCTCGCGGGGCTGGCGGGCGCCGCACCCCCTCCCTGGCCGCCTGCGCCCCGGGG
AGGCCGCCCGCGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGG
ACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCACCCCGAGGCCACC
GTGCCCCAGTACCATGCGGTGAAGATTCCTCGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCTGAGGAACAACTGG
GGCAGCCCCCGGCGGGAGGGCCCGGATGCACACCCCATCCTGGCTGCTGACGGGCATCCCGAGCTGGGCCCCGATGGGCATCCAGGGCCA
GGCACCGCCTAGGTTCCCATGTCCCAGCCTGGCCTGTGGCTGCCCTCCATCCCTTCCCCAGAGATGGCTCCTTGGGATGAAGAGGGTAGA
GTGGGCTGCTGGTGTCGCATCAAGATTTGGCAGGATCGGCTTCCTCAGGGGCACAGACCTCTCCCACCCACAAGAACTCCTCCCACCCAA
CTTCCCCTTAGAGTGCTGTGAGATGAGAGTGGGTAAATCAGGGACAGGGCCATGGGGTAGGGTGAGAAGGGCAGGGGTGTCCTGATGCAA
AGGTGGGGAGAAGGGATCCTAATCCCTTCCTCTCCCATTCACCCTGTGTAACAGGACCCCAAGGACCTGCCTCCCCGGAAGTGCCTTAAC
CTAGAGGGTCGGGGAGGAGGTTGTGTCACTGACTCAGGCTGCTCCTTCTCTAGTTTCCCCTCTCATCTGACCTTAGTTTGCTGCCATCAG

>72492_72492_6_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000542104_ITGA7_chr12_56079072_ENST00000553804_length(amino acids)=240AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLAGAGLALGRSPEEGG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RASSF3-ITGA7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RASSF3-ITGA7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RASSF3-ITGA7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource