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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RASSF3-STK10 (FusionGDB2 ID:72501)

Fusion Gene Summary for RASSF3-STK10

Fusion gene summary

Fusion gene information	Fusion gene name: RASSF3-STK10
	Fusion gene ID: 72501
		Hgene	Tgene
	Gene symbol	RASSF3	STK10
	Gene ID	283349	6793
	Gene name	Ras association domain family member 3	serine/threonine kinase 10
	Synonyms	RASSF5	LOK\|PRO2729
	Cytomap	12q14.2	5q35.1
	Type of gene	protein-coding	protein-coding
	Description	ras association domain-containing protein 3Ras association (RalGDS/AF-6) domain family 3Ras association (RalGDS/AF-6) domain family member 3	serine/threonine-protein kinase 10lymphocyte-oriented kinase
	Modification date	20200327	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000540088, ENST00000336061, ENST00000542104,	ENST00000176763, ENST00000517775,
Fusion gene scores	* DoF score	18 X 7 X 12=1512	16 X 15 X 7=1680
	# samples	18	17
	** MAII score	log2(18/1512*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/1680*10)=-3.30485458152842 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RASSF3 [Title/Abstract] AND STK10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RASSF3(65004523)-STK10(171491816), # samples:4
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	STK10	GO:0046777	protein autophosphorylation	12639966\|18239682

Fusion gene breakpoints across RASSF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STK10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-FX-A2QS-01A	RASSF3	chr12	65004523	-	STK10	chr5	171491816	-
ChimerDB4	SARC	TCGA-FX-A2QS-01A	RASSF3	chr12	65004523	+	STK10	chr5	171491816	-
ChimerDB4	SARC	TCGA-FX-A2QS	RASSF3	chr12	65004523	+	STK10	chr5	171491816	-

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Fusion Gene ORF analysis for RASSF3-STK10

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000540088	ENST00000176763	RASSF3	chr12	65004523	+	STK10	chr5	171491816	-
3UTR-intron	ENST00000540088	ENST00000517775	RASSF3	chr12	65004523	+	STK10	chr5	171491816	-
5CDS-intron	ENST00000336061	ENST00000517775	RASSF3	chr12	65004523	+	STK10	chr5	171491816	-
5CDS-intron	ENST00000542104	ENST00000517775	RASSF3	chr12	65004523	+	STK10	chr5	171491816	-
In-frame	ENST00000336061	ENST00000176763	RASSF3	chr12	65004523	+	STK10	chr5	171491816	-
In-frame	ENST00000542104	ENST00000176763	RASSF3	chr12	65004523	+	STK10	chr5	171491816	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000336061

RASSF3

chr12

65004523

ENST00000176763

STK10

chr5

171491816

3881

154

1179

393

ENST00000542104

RASSF3

chr12

65004523

ENST00000176763

STK10

chr5

171491816

3958

231

1256

419

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000336061	ENST00000176763	RASSF3	chr12	65004523	+	STK10	chr5	171491816	-	0.002691368	0.9973086
ENST00000542104	ENST00000176763	RASSF3	chr12	65004523	+	STK10	chr5	171491816	-	0.002839876	0.9971602

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Fusion Genomic Features for RASSF3-STK10

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RASSF3-STK10

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:65004523/chr5:171491816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

STK10

chr12:65004523

chr5:171491816

ENST00000176763

750_884

663

969.0

Compositional bias

Note=Gln-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RASSF3

chr12:65004523

chr5:171491816

ENST00000336061

187_234

239.0

Domain

SARAH

Hgene

RASSF3

chr12:65004523

chr5:171491816

ENST00000336061

79_186

239.0

Domain

Ras-associating

Hgene

RASSF3

chr12:65004523

chr5:171491816

ENST00000542104

187_234

239.0

Domain

SARAH

Hgene

RASSF3

chr12:65004523

chr5:171491816

ENST00000542104

79_186

239.0

Domain

Ras-associating

Tgene

STK10

chr12:65004523

chr5:171491816

ENST00000176763

573_947

663

969.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

STK10

chr12:65004523

chr5:171491816

ENST00000176763

36_294

663

969.0

Domain

Protein kinase

Tgene

STK10

chr12:65004523

chr5:171491816

ENST00000176763

42_50

663

969.0

Nucleotide binding

ATP

Tgene

STK10

chr12:65004523

chr5:171491816

ENST00000176763

175_224

663

969.0

Region

Note=Activation segment

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Fusion Gene Sequence for RASSF3-STK10

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>72501_72501_1_RASSF3-STK10_RASSF3_chr12_65004523_ENST00000336061_STK10_chr5_171491816_ENST00000176763_length(transcript)=3881nt_BP=154nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTT
CTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAAGTGAAGAACGAGGTGGAGAAGCTCCC
CCGACAGCAGCGGAAGGAAAGCATGAAGCAGAAGATGGAGGAGCACACGCAGAAAAAGCAGCTTCTTGACCGGGACTTTGTAGCCAAGCA
GAAGGAGGACCTGGAGCTGGCCATGAAGAGGCTCACCACCGACAACAGGCGGGAGATCTGTGACAAGGAGCGCGAGTGCCTCATGAAGAA
GCAGGAGCTCCTTCGAGACCGGGAAGCAGCCCTGTGGGAGATGGAAGAGCACCAGCTGCAGGAGAGGCACCAGCTGGTGAAGCAGCAGCT
CAAAGACCAGTACTTCCTCCAGCGGCACGAGCTGCTGCGCAAGCATGAGAAGGAGCGGGAGCAGATGCAGCGCTACAACCAGCGCATGAT
AGAGCAGCTGAAGGTGCGGCAGCAACAGGAAAAGGCGCGGCTGCCCAAGATCCAGAGGAGTGAGGGCAAGACGCGCATGGCCATGTACAA
GAAGAGCCTCCACATCAACGGCGGGGGCAGCGCAGCTGAGCAGCGTGAGAAGATCAAGCAGTTCTCCCAGCAGGAGGAGAAGAGGCAGAA
GTCGGAGCGGCTGCAGCAACAGCAGAAACACGAGAACCAGATGCGGGACATGCTGGCGCAGTGTGAGAGCAACATGAGCGAGCTGCAGCA
GCTGCAGAATGAAAAGTGCCACCTCCTGGTAGAGCACGAAACCCAGAAACTGAAGGCCCTGGATGAGAGCCATAACCAGAACCTGAAGGA
ATGGCGGGACAAGCTTCGGCCGCGCAAGAAGGCTCTGGAAGAGGATCTGAACCAGAAGAAGCGGGAGCAGGAGATGTTCTTCAAGCTGAG
CGAGGAGGCGGAGTGCCCAAACCCCTCCACCCCAAGCAAGGCCGCCAAGTTCTTCCCCTACAGTTCTGCGGATGCTTCTTAACAACCGCC
CGGGGCTGTGGCTGGCAGCTTGGTGGGCCCCAGGGCCTTCTCCTTCATTCTCTGTGAACATGTAACTCAGGACCCCTTTTCCCTCTTGCG
TCTGTGCCAGCTCAAATCCAGCCCCTCGCCCTGTGCCACCCCAACTGTGCCTGATAGACCTGCCCCAGCGTTCCTGACTTCTTGCTGGCC
TGTGGAGGGTGAGGTGTAATTATTTGTCACCTGAACCTAATGTATATTCTCCTTGAGCCCCAGATCCCTTCAAGCTGGAAGGGATGGGGC
TGTTGGTGGGGTCAGGGTCCAAGAGGAATGGGTGTTCTGTGGCCTCGAGTCCTCTCCTGTTTGCGAAAATACCAGTTTTGCTCTCTGTGG
GACAAAGCACTGCTGATGAAGTCCCCGTGGGCTCATCCGGGCTGGAATTCTTGGTTTTTCAGCCATTCCCTGCAGAGTCACTCAATCATC
AAGTCCCTCACAGCCATTTCTGTTCCCAGAGGAGCCAGGCCTGCAGCTGGCTGCTCAGGAGATGGCCTCATTCCTCCTGTTCTCCCAGTT
TGCTTTCCACTTAAGACAAAGCCTTGTCTATGTGGGGGGCGGGGACCGGGGAAAGAGGGAGGCTGAAATGTTTATTCTGCTTCTCCCGTG
TTTCATGCCATCTCGCGTCCCCCTTCCTGCACATGGGTGTGAATGCACACACATACGCGTACACACAGGACTTGGTCTGCTGGCCTGGCC
TCTTCTGCCCAGGTGGGTTGGAACACGTTTGCTGCCTGAGCCTGTGCCACTGAGCATGTTAGGTGGAGCAGTTGGTGTGGCACGTGCGGG
GTGTTGGCACCGGAGGCATGGAAAAGCACAGGCTGTACTGCCAGGCTGCGATGCGTGCTGGCCCCCGCACAGGCTCCTGTGTGCAGGGAC
TGATTCCTCAGCACACGAGGCTTCCACAACCCAGTCTGCTCCATAGCACTCTGGCCCACCCTGTCTGCAGGTGAAACAGGAGGGCTGTTT
GCCTCTGCCCCATCCCCCCGACTGTGTTCAGGAGTCCCACCTTGCATTTCAGACCTGGGCTGGCAGTCTGTTGGACTTCTCTTCAGGAAG
AAAAAGCATCAGGGGGAAATGGAATGCCCCTGCCCCAGGAACATGGCAGAAGCACAGGTTCTGTACCTCAGATGGACTCCTGCTGGGCCT
TCGGGGTCTCAGTTGGCTTCCCCCAGATTCTGATTCTACAGCTGCAGAATGTATATAACGCAATAAAAGCAAATGTTTGAACCAGTATGC
GGGTTTACTTACAAGGAAACCTTTTTTCACCCTGATTTCTAATTATTTTATTGAAACAACTATAAAATGTATGGTTTCTCCAGGAAGATA
TCTGCTTTTTAAAACAACAAACAAGAACAACAACACAAAACTGGTAATGATTTGGAGTAATCATGCGGGCATATTGAGTCTGGGTAGTGT
TTCGCTGGTGGTAGAGTGGTTGAGACTTCCTGGGAGGACTTTTTCCGCCTTCACTCCTACAGATTTAAGATTCTTTATTTTTAGGCCGGG
CATGGTGACTCACCTGAGGTGAGGAGTTCGAGACTAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAGTACAAAAATTAGCCAG
GCGTGGTGGTGCATGCCTATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTAAGCC
AAGGTCACACCACTGCACTCCAGCCTAGGTGACAGGGCGAGACTCTGTCTCTCAAAAAAAAAAAAAAAAAAAATTCTTTGAGACAGGGTC
TCTAATATGTTGCCCAAGCTGATCTCAAACTCGTGGCTCAACTGATTCTCCCGCTTCAACCTTGAGTAGCTGGGACGACAGATACATGCT
ACTGCACCCAGCTAGGTTAAGGTTCTGTATACTCTGTCTTTCTAAAGCAATTCCCTGGAAATTTTCTCAACATTGGTTATAACTGAATGC
TTGGGAAGGGAGGGGCAGCCCTTCAACAGGAAAAGGGGACTGCCCAAATCTTAAATGCACAGTCAAGATTCTCTTGGAGCTAGCAATGGT
TCTCAGGTTAGTGAGCATTTAGCTTGCCTGCTGCAGAATTTGACCCAGATGGGGGTGTTTTTTAGGTCTCTCACAAATGAGACAAGCGAA
ACAATTGTCTCCTTTTATTCTCTTTGGTGCATTGGTGCTGGGGAAACATGAACTAGCGGCAGTGTAACTGCAGAACATAGACCCAGTTCT
ACCAGGCCAGGCCAGCGTTGGGAACCACCAGACAGGGCTGCTTTGGGCTTTGCTTACAGTATTTCCATGTGTAGCCTGGCGTGTGAGAAA
GTATTAGGTGAAATGCCAGTTTCATGGTTCAGGTGAAAGTCTGTGATCATTCCCCTCGTGGCTCGTCCTTCACATCACTTTTGCCCTTCA
AGGAGTTGCCGCGTCCCCGCTCAGTGCCGCCTGAGCCCTCAGAGCTCCCCTGTGCTTTTCTGGATGGGGACTGGCGGGGTCACCTAGCCT
CACCGTGGAGCCACCGTGCAATGCCCATCTCTGAGAGGCCCACGCGGTATTCCTCGTGCCCTGTGTTAGTGCTTTCTGTATAAGGGACAG
ACAGAACTGGGTTTTTTTCCTCTGTCTGGTTTTAGAGTAAATGTAACTAACTTTTATTTTCCCTTTATGAAAGATAGAAATTATTTTTAT
GTAGTTTCCAGACTTTATACAAAATTTTTGTAAAATGTTCTCTGGAAAGTTAACTACAAGAATGTAAATATGCTTCTAATAAAATAACAA

>72501_72501_1_RASSF3-STK10_RASSF3_chr12_65004523_ENST00000336061_STK10_chr5_171491816_ENST00000176763_length(amino acids)=393AA_BP=1
MAQTQEGKGVLSYMFTENEGEGPGAHQAASHSPGRLLRSIRRTVGEELGGLAWGGGVWALRLLAQLEEHLLLPLLLVQILFQSLLARPKL
VPPFLQVLVMALIQGLQFLGFVLYQEVALFILQLLQLAHVALTLRQHVPHLVLVFLLLLQPLRLLPLLLLLGELLDLLTLLSCAAPAVDV
EALLVHGHARLALTPLDLGQPRLFLLLPHLQLLYHALVVALHLLPLLLMLAQQLVPLEEVLVFELLLHQLVPLLQLVLFHLPQGCFPVSK
ELLLLHEALALLVTDLPPVVGGEPLHGQLQVLLLLGYKVPVKKLLFLRVLLHLLLHAFLPLLSGELLHLVLHLLAGAGLALGRSPEEGGP

--------------------------------------------------------------
>72501_72501_2_RASSF3-STK10_RASSF3_chr12_65004523_ENST00000542104_STK10_chr5_171491816_ENST00000176763_length(transcript)=3958nt_BP=231nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGCCGGGAACCTCGCGGGGCTGGCGGGCGCCGCACCCCCTCCCTGGCCGCCTGCGCCCCGGGG
AGGCCGCCCGCGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGG
ACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAAGTGAAGAACGAGGTGGAGAAGCTCCCCCGACAGCAGCGG
AAGGAAAGCATGAAGCAGAAGATGGAGGAGCACACGCAGAAAAAGCAGCTTCTTGACCGGGACTTTGTAGCCAAGCAGAAGGAGGACCTG
GAGCTGGCCATGAAGAGGCTCACCACCGACAACAGGCGGGAGATCTGTGACAAGGAGCGCGAGTGCCTCATGAAGAAGCAGGAGCTCCTT
CGAGACCGGGAAGCAGCCCTGTGGGAGATGGAAGAGCACCAGCTGCAGGAGAGGCACCAGCTGGTGAAGCAGCAGCTCAAAGACCAGTAC
TTCCTCCAGCGGCACGAGCTGCTGCGCAAGCATGAGAAGGAGCGGGAGCAGATGCAGCGCTACAACCAGCGCATGATAGAGCAGCTGAAG
GTGCGGCAGCAACAGGAAAAGGCGCGGCTGCCCAAGATCCAGAGGAGTGAGGGCAAGACGCGCATGGCCATGTACAAGAAGAGCCTCCAC
ATCAACGGCGGGGGCAGCGCAGCTGAGCAGCGTGAGAAGATCAAGCAGTTCTCCCAGCAGGAGGAGAAGAGGCAGAAGTCGGAGCGGCTG
CAGCAACAGCAGAAACACGAGAACCAGATGCGGGACATGCTGGCGCAGTGTGAGAGCAACATGAGCGAGCTGCAGCAGCTGCAGAATGAA
AAGTGCCACCTCCTGGTAGAGCACGAAACCCAGAAACTGAAGGCCCTGGATGAGAGCCATAACCAGAACCTGAAGGAATGGCGGGACAAG
CTTCGGCCGCGCAAGAAGGCTCTGGAAGAGGATCTGAACCAGAAGAAGCGGGAGCAGGAGATGTTCTTCAAGCTGAGCGAGGAGGCGGAG
TGCCCAAACCCCTCCACCCCAAGCAAGGCCGCCAAGTTCTTCCCCTACAGTTCTGCGGATGCTTCTTAACAACCGCCCGGGGCTGTGGCT
GGCAGCTTGGTGGGCCCCAGGGCCTTCTCCTTCATTCTCTGTGAACATGTAACTCAGGACCCCTTTTCCCTCTTGCGTCTGTGCCAGCTC
AAATCCAGCCCCTCGCCCTGTGCCACCCCAACTGTGCCTGATAGACCTGCCCCAGCGTTCCTGACTTCTTGCTGGCCTGTGGAGGGTGAG
GTGTAATTATTTGTCACCTGAACCTAATGTATATTCTCCTTGAGCCCCAGATCCCTTCAAGCTGGAAGGGATGGGGCTGTTGGTGGGGTC
AGGGTCCAAGAGGAATGGGTGTTCTGTGGCCTCGAGTCCTCTCCTGTTTGCGAAAATACCAGTTTTGCTCTCTGTGGGACAAAGCACTGC
TGATGAAGTCCCCGTGGGCTCATCCGGGCTGGAATTCTTGGTTTTTCAGCCATTCCCTGCAGAGTCACTCAATCATCAAGTCCCTCACAG
CCATTTCTGTTCCCAGAGGAGCCAGGCCTGCAGCTGGCTGCTCAGGAGATGGCCTCATTCCTCCTGTTCTCCCAGTTTGCTTTCCACTTA
AGACAAAGCCTTGTCTATGTGGGGGGCGGGGACCGGGGAAAGAGGGAGGCTGAAATGTTTATTCTGCTTCTCCCGTGTTTCATGCCATCT
CGCGTCCCCCTTCCTGCACATGGGTGTGAATGCACACACATACGCGTACACACAGGACTTGGTCTGCTGGCCTGGCCTCTTCTGCCCAGG
TGGGTTGGAACACGTTTGCTGCCTGAGCCTGTGCCACTGAGCATGTTAGGTGGAGCAGTTGGTGTGGCACGTGCGGGGTGTTGGCACCGG
AGGCATGGAAAAGCACAGGCTGTACTGCCAGGCTGCGATGCGTGCTGGCCCCCGCACAGGCTCCTGTGTGCAGGGACTGATTCCTCAGCA
CACGAGGCTTCCACAACCCAGTCTGCTCCATAGCACTCTGGCCCACCCTGTCTGCAGGTGAAACAGGAGGGCTGTTTGCCTCTGCCCCAT
CCCCCCGACTGTGTTCAGGAGTCCCACCTTGCATTTCAGACCTGGGCTGGCAGTCTGTTGGACTTCTCTTCAGGAAGAAAAAGCATCAGG
GGGAAATGGAATGCCCCTGCCCCAGGAACATGGCAGAAGCACAGGTTCTGTACCTCAGATGGACTCCTGCTGGGCCTTCGGGGTCTCAGT
TGGCTTCCCCCAGATTCTGATTCTACAGCTGCAGAATGTATATAACGCAATAAAAGCAAATGTTTGAACCAGTATGCGGGTTTACTTACA
AGGAAACCTTTTTTCACCCTGATTTCTAATTATTTTATTGAAACAACTATAAAATGTATGGTTTCTCCAGGAAGATATCTGCTTTTTAAA
ACAACAAACAAGAACAACAACACAAAACTGGTAATGATTTGGAGTAATCATGCGGGCATATTGAGTCTGGGTAGTGTTTCGCTGGTGGTA
GAGTGGTTGAGACTTCCTGGGAGGACTTTTTCCGCCTTCACTCCTACAGATTTAAGATTCTTTATTTTTAGGCCGGGCATGGTGACTCAC
CTGAGGTGAGGAGTTCGAGACTAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAGTACAAAAATTAGCCAGGCGTGGTGGTGCA
TGCCTATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTAAGCCAAGGTCACACCAC
TGCACTCCAGCCTAGGTGACAGGGCGAGACTCTGTCTCTCAAAAAAAAAAAAAAAAAAAATTCTTTGAGACAGGGTCTCTAATATGTTGC
CCAAGCTGATCTCAAACTCGTGGCTCAACTGATTCTCCCGCTTCAACCTTGAGTAGCTGGGACGACAGATACATGCTACTGCACCCAGCT
AGGTTAAGGTTCTGTATACTCTGTCTTTCTAAAGCAATTCCCTGGAAATTTTCTCAACATTGGTTATAACTGAATGCTTGGGAAGGGAGG
GGCAGCCCTTCAACAGGAAAAGGGGACTGCCCAAATCTTAAATGCACAGTCAAGATTCTCTTGGAGCTAGCAATGGTTCTCAGGTTAGTG
AGCATTTAGCTTGCCTGCTGCAGAATTTGACCCAGATGGGGGTGTTTTTTAGGTCTCTCACAAATGAGACAAGCGAAACAATTGTCTCCT
TTTATTCTCTTTGGTGCATTGGTGCTGGGGAAACATGAACTAGCGGCAGTGTAACTGCAGAACATAGACCCAGTTCTACCAGGCCAGGCC
AGCGTTGGGAACCACCAGACAGGGCTGCTTTGGGCTTTGCTTACAGTATTTCCATGTGTAGCCTGGCGTGTGAGAAAGTATTAGGTGAAA
TGCCAGTTTCATGGTTCAGGTGAAAGTCTGTGATCATTCCCCTCGTGGCTCGTCCTTCACATCACTTTTGCCCTTCAAGGAGTTGCCGCG
TCCCCGCTCAGTGCCGCCTGAGCCCTCAGAGCTCCCCTGTGCTTTTCTGGATGGGGACTGGCGGGGTCACCTAGCCTCACCGTGGAGCCA
CCGTGCAATGCCCATCTCTGAGAGGCCCACGCGGTATTCCTCGTGCCCTGTGTTAGTGCTTTCTGTATAAGGGACAGACAGAACTGGGTT
TTTTTCCTCTGTCTGGTTTTAGAGTAAATGTAACTAACTTTTATTTTCCCTTTATGAAAGATAGAAATTATTTTTATGTAGTTTCCAGAC

>72501_72501_2_RASSF3-STK10_RASSF3_chr12_65004523_ENST00000542104_STK10_chr5_171491816_ENST00000176763_length(amino acids)=419AA_BP=1
MAQTQEGKGVLSYMFTENEGEGPGAHQAASHSPGRLLRSIRRTVGEELGGLAWGGGVWALRLLAQLEEHLLLPLLLVQILFQSLLARPKL
VPPFLQVLVMALIQGLQFLGFVLYQEVALFILQLLQLAHVALTLRQHVPHLVLVFLLLLQPLRLLPLLLLLGELLDLLTLLSCAAPAVDV
EALLVHGHARLALTPLDLGQPRLFLLLPHLQLLYHALVVALHLLPLLLMLAQQLVPLEEVLVFELLLHQLVPLLQLVLFHLPQGCFPVSK
ELLLLHEALALLVTDLPPVVGGEPLHGQLQVLLLLGYKVPVKKLLFLRVLLHLLLHAFLPLLSGELLHLVLHLLAGAGLALGRSPEEGGP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RASSF3-STK10

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RASSF3-STK10

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RASSF3-STK10

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source