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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RB1CC1-SNX16 (FusionGDB2 ID:72553)

Fusion Gene Summary for RB1CC1-SNX16

check button Fusion gene summary
Fusion gene informationFusion gene name: RB1CC1-SNX16
Fusion gene ID: 72553
HgeneTgene
Gene symbol

RB1CC1

SNX16

Gene ID

9821

64089

Gene nameRB1 inducible coiled-coil 1sorting nexin 16
SynonymsATG17|CC1|FIP200|PPP1R131-
Cytomap

8q11.23

8q21.13

Type of geneprotein-codingprotein-coding
DescriptionRB1-inducible coiled-coil protein 1200 kDa FAK family kinase-interacting proteinFAK family kinase-interacting protein of 200 kDaphosphatase 1, regulatory subunit 131sorting nexin-16
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000539297, ENST00000025008, 
ENST00000435644, ENST00000521611, 
ENST00000345957, ENST00000353788, 
ENST00000396330, 
Fusion gene scores* DoF score8 X 6 X 6=2882 X 2 X 2=8
# samples 92
** MAII scorelog2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: RB1CC1 [Title/Abstract] AND SNX16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRB1CC1(53568568)-SNX16(82736175), # samples:2
Anticipated loss of major functional domain due to fusion event.RB1CC1-SNX16 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RB1CC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SNX16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A2MH-06ARB1CC1chr8

53568568

-SNX16chr8

82736175

-


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Fusion Gene ORF analysis for RB1CC1-SNX16

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000539297ENST00000345957RB1CC1chr8

53568568

-SNX16chr8

82736175

-
Frame-shiftENST00000539297ENST00000353788RB1CC1chr8

53568568

-SNX16chr8

82736175

-
Frame-shiftENST00000539297ENST00000396330RB1CC1chr8

53568568

-SNX16chr8

82736175

-
In-frameENST00000025008ENST00000345957RB1CC1chr8

53568568

-SNX16chr8

82736175

-
In-frameENST00000025008ENST00000353788RB1CC1chr8

53568568

-SNX16chr8

82736175

-
In-frameENST00000025008ENST00000396330RB1CC1chr8

53568568

-SNX16chr8

82736175

-
In-frameENST00000435644ENST00000345957RB1CC1chr8

53568568

-SNX16chr8

82736175

-
In-frameENST00000435644ENST00000353788RB1CC1chr8

53568568

-SNX16chr8

82736175

-
In-frameENST00000435644ENST00000396330RB1CC1chr8

53568568

-SNX16chr8

82736175

-
intron-3CDSENST00000521611ENST00000345957RB1CC1chr8

53568568

-SNX16chr8

82736175

-
intron-3CDSENST00000521611ENST00000353788RB1CC1chr8

53568568

-SNX16chr8

82736175

-
intron-3CDSENST00000521611ENST00000396330RB1CC1chr8

53568568

-SNX16chr8

82736175

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000025008RB1CC1chr853568568-ENST00000353788SNX16chr882736175-6834434552443481274
ENST00000025008RB1CC1chr853568568-ENST00000396330SNX16chr882736175-6828434552443481274
ENST00000025008RB1CC1chr853568568-ENST00000345957SNX16chr882736175-5457434552443481274
ENST00000435644RB1CC1chr853568568-ENST00000353788SNX16chr882736175-6825433651543391274
ENST00000435644RB1CC1chr853568568-ENST00000396330SNX16chr882736175-6819433651543391274
ENST00000435644RB1CC1chr853568568-ENST00000345957SNX16chr882736175-5448433651543391274

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000025008ENST00000353788RB1CC1chr853568568-SNX16chr882736175-0.0001292070.9998708
ENST00000025008ENST00000396330RB1CC1chr853568568-SNX16chr882736175-0.0001286570.9998714
ENST00000025008ENST00000345957RB1CC1chr853568568-SNX16chr882736175-0.0002961460.9997038
ENST00000435644ENST00000353788RB1CC1chr853568568-SNX16chr882736175-0.0001291740.9998708
ENST00000435644ENST00000396330RB1CC1chr853568568-SNX16chr882736175-0.0001284060.9998716
ENST00000435644ENST00000345957RB1CC1chr853568568-SNX16chr882736175-0.0002976990.9997023

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Fusion Genomic Features for RB1CC1-SNX16


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RB1CC1-SNX16


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:53568568/chr8:82736175)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRB1CC1chr8:53568568chr8:82736175ENST00000025008-1524663_66612731595.0Compositional biasNote=Poly-Thr
HgeneRB1CC1chr8:53568568chr8:82736175ENST00000435644-1524663_66612731592.0Compositional biasNote=Poly-Thr
HgeneRB1CC1chr8:53568568chr8:82736175ENST00000539297-1322663_66612731592.0Compositional biasNote=Poly-Thr
HgeneRB1CC1chr8:53568568chr8:82736175ENST00000025008-1524566_56912731595.0MotifNuclear localization signal
HgeneRB1CC1chr8:53568568chr8:82736175ENST00000435644-1524566_56912731592.0MotifNuclear localization signal
HgeneRB1CC1chr8:53568568chr8:82736175ENST00000539297-1322566_56912731592.0MotifNuclear localization signal
TgeneSNX16chr8:53568568chr8:82736175ENST0000034595728223_278154345.0Coiled coilOntology_term=ECO:0000255
TgeneSNX16chr8:53568568chr8:82736175ENST0000035378817223_278125316.0Coiled coilOntology_term=ECO:0000255
TgeneSNX16chr8:53568568chr8:82736175ENST0000039633039223_278154345.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRB1CC1chr8:53568568chr8:82736175ENST00000025008-15241438_148512731595.0Coiled coilOntology_term=ECO:0000255
HgeneRB1CC1chr8:53568568chr8:82736175ENST00000025008-1524859_139712731595.0Coiled coilOntology_term=ECO:0000255
HgeneRB1CC1chr8:53568568chr8:82736175ENST00000435644-15241438_148512731592.0Coiled coilOntology_term=ECO:0000255
HgeneRB1CC1chr8:53568568chr8:82736175ENST00000435644-1524859_139712731592.0Coiled coilOntology_term=ECO:0000255
HgeneRB1CC1chr8:53568568chr8:82736175ENST00000539297-13221438_148512731592.0Coiled coilOntology_term=ECO:0000255
HgeneRB1CC1chr8:53568568chr8:82736175ENST00000539297-1322859_139712731592.0Coiled coilOntology_term=ECO:0000255
TgeneSNX16chr8:53568568chr8:82736175ENST0000034595728105_218154345.0DomainPX
TgeneSNX16chr8:53568568chr8:82736175ENST0000035378817105_218125316.0DomainPX
TgeneSNX16chr8:53568568chr8:82736175ENST0000039633039105_218154345.0DomainPX


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Fusion Gene Sequence for RB1CC1-SNX16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72553_72553_1_RB1CC1-SNX16_RB1CC1_chr8_53568568_ENST00000025008_SNX16_chr8_82736175_ENST00000345957_length(transcript)=5457nt_BP=4345nt
GTCGACAATAACAAACCAAGCCGCGGCGGTGTCCGCGGCCCTGCCGAGCCCTCGGCGTTGCCTCAGAATCCCCCAGTCGCCTGGGCCCCT
CGGCTCTGACAGGCCGCGGCCTTCTGTCCCCCGGCCCCAGACCCAGAGCCGAGGGGCCTGCTCGCGTCCTTGTCCGCCCGGACCCCTCCC
TGCCTCCTAGAGTTCGGGGCCGCGGCGGGCGGGCGCCCGGGACGCCGGCGGTTGTGTCGGCTTAGCGGTGCCGAATGGGCGGTTGGTAAC
CGCTGCCGAGGACTAGGCGGCGGCGGAAGATGGTGCCGGGGGTCGCTGGCTCTGCTGCTGCCGCCGGCGAAGGAGGAGGCGTTGCCGGTT
TTCTGAGTTTAACCAGTAATGCCATTCAGTTGCCAATCTCAAGCAAAGCAAACATAAGCCAGTTTTAATCTACTTTTTAAGAAAAGTGGT
AGTCCTTTTCACAGTGCCTGACGTAACTGTATCAGAGGGTGAGGTATAAGCTCACAGAATTCAGATAAATCATCATGAAGTTATATGTAT
TTCTGGTTAACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCATGCCATTCAAAGCAAAT
ACAAGATTGCTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGTACCTACAGTGCTGGGA
CGGATACAAATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACTACCTTTTCGACAGAAA
ATGACATGGAAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAGCTTGCATTGGAAATGT
ATGAAGTTGCCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGGGCTGCAATCATGGCCA
ACCTGGAGGACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAGTCCATAGAAGACATCA
AGTTAAAACTTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGACATAGTTACAGAGAAT
GTTTGGGAAGACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTGGTGCTCTCTCCTGATA
TGCCTAGAACAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCAGATGCTGAAAGTGGCA
AAGAAATTAGGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGATCTGCCCTTTTTTAATG
TCTCTTTGTTAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGATTCTATGAGCAGGCTTG
ATCCAAGGATTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAAGCCATTAAAGGACTTG
AAGATCGGCTCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCTCAGGGATTTTTAGCTA
ATCAGAAGAGAGCTGAAAACTTAAAGGATGCATCTGTATTACCTGATTTATGCCTGAGTCACGCAAATCAGTTGATGATTATGTTGCAAA
ATCATAGAAAACTGTTAGATATTAAGCAGAAGTGTACCACTGCCAAACAAGAACTAGCAAATAACCTACATGTCAGACTGAAGTGGTGTT
GCTTTGTAATGCTTCATGCTGATCAAGATGGAGAGAAGTTACAAGCTTTGCTCCGCCTCGTAATAGAGCTGTTAGAAAGAGTCAAAATTG
TTGAAGCTCTTAGTACAGTTCCTCAGATGTACTGCTTAGCTGTTGTTGAGGTTGTAAGAAGAAAAATGTTCATAAAACACTACAGGGAGT
GGGCTGGTGCTTTAGTCAAAGATGGAAAGAGATTATATGAAGCAGAAAAATCAAAAAGGGAATCCTTTGGGAAATTATTTAGGAAGTCTT
TTTTAAGAAATCGTCTGTTTAGGGGACTGGACTCCTGGCCCCCTTCCTTTTGTACTCAAAAGCCTCGAAAGTTTGACTGTGAACTTCCAG
ATATTTCATTAAAAGATTTACAGTTTCTGCAATCATTTTGTCCTTCGGAAGTTCAGCCATTCCTCAGGGTTCCCTTACTTTGTGACTTTG
AACCTCTACACCAGCATGTACTTGCTCTACATAATTTGGTAAAAGCAGCACAAAGTTTGGATGAAATGTCACAGACCATTACAGATCTAC
TGAGTGAACAAAAGGCATCTGTGAGTCAGACATCCCCACAGTCTGCTTCTTCACCAAGGATGGAAAGTACAGCAGGAATTACAACTACTA
CCTCACCGAGAACTCCTCCACCACTGACTGTTCAGGATCCCTTATGTCCTGCAGTTTGTCCCTTAGAAGAATTATCTCCAGATAGTATTG
ATGCACATACGTTTGATTTTGAAACTATTCCCCATCCAAACATAGAACAGACTATTCACCAAGTTTCTTTAGACTTGGATTCATTAGCAG
AAAGTCCTGAATCAGATTTTATGTCTGCTGTGAATGAGTTTGTAATAGAAGAAAATTTGTCGTCTCCTAATCCTATAAGTGATCCACAAA
GCCCAGAAATGATGGTGGAATCACTTTATTCATCAGTTATCAATGCGATAGACAGTAGACGAATGCAGGATACAAATGTATGTGGTAAGG
AGGATTTTGGAGATCATACTTCTCTGAATGTCCAGTTGGAAAGATGTAGAGTTGTTGCCCAAGACTCTCACTTCAGTATACAAACCATTA
AGGAAGACCTTTGCCACTTTAGAACATTTGTACAAAAAGAACAGTGTGACTTCTCAAATTCATTAAAATGTACAGCAGTAGAAATAAGAA
ACATTATTGAAAAAGTAAAATGTTCTCTGGAAATAACACTAAAAGAAAAACATCAAAAAGAACTACTGTCTTTAAAAAATGAATATGAAG
GTAAACTTGACGGACTAATAAAGGAAACTGAAGAGAATGAAAACAAAATTAAAAAATTGAAGGGAGAGTTAGTATGCCTTGAGGAGGTTT
TACAAAATAAAGATAATGAATTTGCTTTGGTTAAACATGAAAAAGAAGCTGTAATCTGCCTGCAGAATGAAAAGGATCAGAAGTTGTTAG
AGATGGAAAATATAATGCACTCTCAAAATTGTGAAATTAAAGAACTGAAGCAGTCACGAGAAATAGTGTTAGAAGACTTAAAAAAGCTCC
ATGTTGAAAATGATGAGAAGTTACAGTTATTGAGGGCAGAACTTCAGTCCTTGGAGCAAAGTCATCTAAAGGAATTAGAGGACACACTTC
AGGTTAGGCACATACAAGAGTTTGAGAAGGTTATGACAGACCACAGAGTTTCTTTGGAGGAATTAAAAAAGGAAAACCAACAAATAATTA
ATCAAATACAAGAATCTCATGCTGAAATTATCCAGGAAAAAGAAAAACAGTTACAGGAATTAAAACTCAAGGTTTCTGATTTGTCAGACA
CGAGATGCAAGTTAGAGGTTGAACTTGCGTTGAAGGAAGCAGAAACTGATGAAATAAAAATTTTGCTGGAAGAAAGCAGAGCCCAGCAGA
AGGAGACCTTGAAATCTCTTCTTGAACAAGAGACAGAAAATTTGAGAACAGAAATTAGTAAACTCAACCAAAAGATTCAGGATAATAATG
AAAATTATCAGGTGGGCTTAGCAGAGCTAAGAACTTTAATGACAATTGAAAAAGATCAGTGTATTTCCGAGTTAATTAGTAGACATGAAG
AAGAATCTAATATACTTAAAGCTGAATTAAACAAAGTAACATCTTTGCATAACCAAGCATTTGAAATAGAAAAAAACCTAAAAGAACAAA
TAATTGAACTGCAGAGTAAATTGGATTCAGAATTGAGTGCTCTTGAAAGACAAAAAGATGAAAAAATTACCCAACAAGAAGAGAAATACG
AAGCTATTATCCAGAACCTTGAGAAAGACAGACAAAAATTGGTCAGCAGCCAGGAGCAAGACAGAGAACAGTTAATTCAGAAGCTTAATT
GTGAAAAAGATGAAGCTATTCAGACTGCCCTAAAAGAATTTAAATTGGAGAGAGAAGTTGTTGAGAAAGAGTTATTAGAAAAAGTTAAAC
ATCTTGAGAATCAAATAGCAAAAAGTTAAAAGAGATGTTTCCAGGTTTTCGACTAGCACTTCCTCCAAAACGCTGGTTTAAAGATAATTA
CAATGCTGACTTTTTAGAAGACAGACAATTAGGATTACAAGCGTTTCTTCAAAATTTAGTAGCTCACAAGGACATTGCTAACTGCCTTGC
AGTGAGAGAATTTCTTTGTTTGGATGATCCACCGGGTCCATTTGATAGCCTAGAAGAAAGCAGGGCATTCTGTGAAACTTTAGAAGAGAC
AAACTACCGCTTACAGAAAGAACTACTTGAAAAACAAAAGGAGATGGAATCACTAAAGAAACTGCTCAGTGAGAAGCAACTTCATATAGA
CACTTTAGAGAACAGAATCAGAACATTGTCTTTAGAACCTGAAGAATCACTGGATGTGTCAGAAACAGAAGGTGAACAGATCCTAAAGGT
GGAGTCCTCTGCACTTGAGGTTGATCAAGATGTCCTGGATGAAGAATCTAGAGCTGATAATAAACCATGCTTAAGTTTTAGTGAACCTGA
AAATGCTGTATCAGAGATAGAAGTAGCAGAAGTGGCATATGATGCTGAAGAAGACTAATGTATCACAAGCAGTTCCCTCCATTTAGACTA
TTCAAAAATTTAGAAGAGTGGCAAATACTATTTTAAAAGAAGAACCAAGAACTGTAAAACATATAGAAAAGAGCAAGAATGCACATGTAT
AAAGTTTACATAAAGAAGTTTTTTTAAGTTATTGAGATAGGAAATATATTCACTGCTGCTTTTAATTGTATTTTATCCAATTACATTTAA
TACACTAAAAAAAATCTTGTTGGAATTCTGTTATCAAGGCCCACATTCTTAAATACTGTGCATAAATTATTATGGTGTTTTGCCTATATA
TTGCTCCAAACTACTGTGTATATATGTATGTGTGTTAAATCACCAATTATATTAATCAAATGGAAATTAATTGCATGTTACTATCTGGGT
GATATATTCTTCTTTATATCTCTGACATGACATATTTTCATTAATAGTTTAAATCAGTGACCATCATAATAAAGATAAAATTTAGTTGAG

>72553_72553_1_RB1CC1-SNX16_RB1CC1_chr8_53568568_ENST00000025008_SNX16_chr8_82736175_ENST00000345957_length(amino acids)=1274AA_BP=
MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRPPAIPKT
TFSTENDMEIKVEESLMMPAVFHTVASRTQLALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ
SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSFPKSVEHVSPDTA
DAESGKEIRESCQSTVHQQDETTIDTKDGDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK
AIKGLEDRLYALDQMIASCGRLVNEQKELAQGFLANQKRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHV
RLKWCCFVMLHADQDGEKLQALLRLVIELLERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESFGK
LFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQ
TITDLLSEQKASVSQTSPQSASSPRMESTAGITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLD
LDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHF
SIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV
CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKE
LEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEE
SRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEK
NLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL

--------------------------------------------------------------
>72553_72553_2_RB1CC1-SNX16_RB1CC1_chr8_53568568_ENST00000025008_SNX16_chr8_82736175_ENST00000353788_length(transcript)=6834nt_BP=4345nt
GTCGACAATAACAAACCAAGCCGCGGCGGTGTCCGCGGCCCTGCCGAGCCCTCGGCGTTGCCTCAGAATCCCCCAGTCGCCTGGGCCCCT
CGGCTCTGACAGGCCGCGGCCTTCTGTCCCCCGGCCCCAGACCCAGAGCCGAGGGGCCTGCTCGCGTCCTTGTCCGCCCGGACCCCTCCC
TGCCTCCTAGAGTTCGGGGCCGCGGCGGGCGGGCGCCCGGGACGCCGGCGGTTGTGTCGGCTTAGCGGTGCCGAATGGGCGGTTGGTAAC
CGCTGCCGAGGACTAGGCGGCGGCGGAAGATGGTGCCGGGGGTCGCTGGCTCTGCTGCTGCCGCCGGCGAAGGAGGAGGCGTTGCCGGTT
TTCTGAGTTTAACCAGTAATGCCATTCAGTTGCCAATCTCAAGCAAAGCAAACATAAGCCAGTTTTAATCTACTTTTTAAGAAAAGTGGT
AGTCCTTTTCACAGTGCCTGACGTAACTGTATCAGAGGGTGAGGTATAAGCTCACAGAATTCAGATAAATCATCATGAAGTTATATGTAT
TTCTGGTTAACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCATGCCATTCAAAGCAAAT
ACAAGATTGCTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGTACCTACAGTGCTGGGA
CGGATACAAATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACTACCTTTTCGACAGAAA
ATGACATGGAAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAGCTTGCATTGGAAATGT
ATGAAGTTGCCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGGGCTGCAATCATGGCCA
ACCTGGAGGACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAGTCCATAGAAGACATCA
AGTTAAAACTTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGACATAGTTACAGAGAAT
GTTTGGGAAGACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTGGTGCTCTCTCCTGATA
TGCCTAGAACAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCAGATGCTGAAAGTGGCA
AAGAAATTAGGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGATCTGCCCTTTTTTAATG
TCTCTTTGTTAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGATTCTATGAGCAGGCTTG
ATCCAAGGATTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAAGCCATTAAAGGACTTG
AAGATCGGCTCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCTCAGGGATTTTTAGCTA
ATCAGAAGAGAGCTGAAAACTTAAAGGATGCATCTGTATTACCTGATTTATGCCTGAGTCACGCAAATCAGTTGATGATTATGTTGCAAA
ATCATAGAAAACTGTTAGATATTAAGCAGAAGTGTACCACTGCCAAACAAGAACTAGCAAATAACCTACATGTCAGACTGAAGTGGTGTT
GCTTTGTAATGCTTCATGCTGATCAAGATGGAGAGAAGTTACAAGCTTTGCTCCGCCTCGTAATAGAGCTGTTAGAAAGAGTCAAAATTG
TTGAAGCTCTTAGTACAGTTCCTCAGATGTACTGCTTAGCTGTTGTTGAGGTTGTAAGAAGAAAAATGTTCATAAAACACTACAGGGAGT
GGGCTGGTGCTTTAGTCAAAGATGGAAAGAGATTATATGAAGCAGAAAAATCAAAAAGGGAATCCTTTGGGAAATTATTTAGGAAGTCTT
TTTTAAGAAATCGTCTGTTTAGGGGACTGGACTCCTGGCCCCCTTCCTTTTGTACTCAAAAGCCTCGAAAGTTTGACTGTGAACTTCCAG
ATATTTCATTAAAAGATTTACAGTTTCTGCAATCATTTTGTCCTTCGGAAGTTCAGCCATTCCTCAGGGTTCCCTTACTTTGTGACTTTG
AACCTCTACACCAGCATGTACTTGCTCTACATAATTTGGTAAAAGCAGCACAAAGTTTGGATGAAATGTCACAGACCATTACAGATCTAC
TGAGTGAACAAAAGGCATCTGTGAGTCAGACATCCCCACAGTCTGCTTCTTCACCAAGGATGGAAAGTACAGCAGGAATTACAACTACTA
CCTCACCGAGAACTCCTCCACCACTGACTGTTCAGGATCCCTTATGTCCTGCAGTTTGTCCCTTAGAAGAATTATCTCCAGATAGTATTG
ATGCACATACGTTTGATTTTGAAACTATTCCCCATCCAAACATAGAACAGACTATTCACCAAGTTTCTTTAGACTTGGATTCATTAGCAG
AAAGTCCTGAATCAGATTTTATGTCTGCTGTGAATGAGTTTGTAATAGAAGAAAATTTGTCGTCTCCTAATCCTATAAGTGATCCACAAA
GCCCAGAAATGATGGTGGAATCACTTTATTCATCAGTTATCAATGCGATAGACAGTAGACGAATGCAGGATACAAATGTATGTGGTAAGG
AGGATTTTGGAGATCATACTTCTCTGAATGTCCAGTTGGAAAGATGTAGAGTTGTTGCCCAAGACTCTCACTTCAGTATACAAACCATTA
AGGAAGACCTTTGCCACTTTAGAACATTTGTACAAAAAGAACAGTGTGACTTCTCAAATTCATTAAAATGTACAGCAGTAGAAATAAGAA
ACATTATTGAAAAAGTAAAATGTTCTCTGGAAATAACACTAAAAGAAAAACATCAAAAAGAACTACTGTCTTTAAAAAATGAATATGAAG
GTAAACTTGACGGACTAATAAAGGAAACTGAAGAGAATGAAAACAAAATTAAAAAATTGAAGGGAGAGTTAGTATGCCTTGAGGAGGTTT
TACAAAATAAAGATAATGAATTTGCTTTGGTTAAACATGAAAAAGAAGCTGTAATCTGCCTGCAGAATGAAAAGGATCAGAAGTTGTTAG
AGATGGAAAATATAATGCACTCTCAAAATTGTGAAATTAAAGAACTGAAGCAGTCACGAGAAATAGTGTTAGAAGACTTAAAAAAGCTCC
ATGTTGAAAATGATGAGAAGTTACAGTTATTGAGGGCAGAACTTCAGTCCTTGGAGCAAAGTCATCTAAAGGAATTAGAGGACACACTTC
AGGTTAGGCACATACAAGAGTTTGAGAAGGTTATGACAGACCACAGAGTTTCTTTGGAGGAATTAAAAAAGGAAAACCAACAAATAATTA
ATCAAATACAAGAATCTCATGCTGAAATTATCCAGGAAAAAGAAAAACAGTTACAGGAATTAAAACTCAAGGTTTCTGATTTGTCAGACA
CGAGATGCAAGTTAGAGGTTGAACTTGCGTTGAAGGAAGCAGAAACTGATGAAATAAAAATTTTGCTGGAAGAAAGCAGAGCCCAGCAGA
AGGAGACCTTGAAATCTCTTCTTGAACAAGAGACAGAAAATTTGAGAACAGAAATTAGTAAACTCAACCAAAAGATTCAGGATAATAATG
AAAATTATCAGGTGGGCTTAGCAGAGCTAAGAACTTTAATGACAATTGAAAAAGATCAGTGTATTTCCGAGTTAATTAGTAGACATGAAG
AAGAATCTAATATACTTAAAGCTGAATTAAACAAAGTAACATCTTTGCATAACCAAGCATTTGAAATAGAAAAAAACCTAAAAGAACAAA
TAATTGAACTGCAGAGTAAATTGGATTCAGAATTGAGTGCTCTTGAAAGACAAAAAGATGAAAAAATTACCCAACAAGAAGAGAAATACG
AAGCTATTATCCAGAACCTTGAGAAAGACAGACAAAAATTGGTCAGCAGCCAGGAGCAAGACAGAGAACAGTTAATTCAGAAGCTTAATT
GTGAAAAAGATGAAGCTATTCAGACTGCCCTAAAAGAATTTAAATTGGAGAGAGAAGTTGTTGAGAAAGAGTTATTAGAAAAAGTTAAAC
ATCTTGAGAATCAAATAGCAAAAAGTTAAAAGAGATGTTTCCAGGTTTTCGACTAGCACTTCCTCCAAAACGCTGGTTTAAAGATAATTA
CAATGCTGACTTTTTAGAAGACAGACAATTAGGATTACAAGCGTTTCTTCAAAATTTAGTAGCTCACAAGGACATTGCTAACTGCCTTGC
AGTGAGAGAATTTCTTTGTTTGGATGATCCACCGGGTCCATTTGATAGCCTAGAAGAAAGCAGGGCATTCTGTGAAACTTTAGAAGAGAC
AAACTACCGCTTACAGAAAGAACTACTTGAAAAACAAAAGGAGATGGAATCACTAAAGAAACTGCTCAGTGAGAAGCAACTTCATATAGA
CACTTTAGAGAACAGAATCAGAACATTGTCTTTAGAACCTGAAGAATCACTGGATGTGTCAGAAACAGAAGGTGAACAGATCCTAAAGGT
GGAGTCCTCTGCACTTGAGGTTGATCAAGATGTCCTGGATGAAGAATCTAGAGCTGATAATAAACCATGCTTAAGTTTTAGTGAACCTGA
AAATGCTGTATCAGAGATAGAAGTAGCAGAAGTGGCATATGATGCTGAAGAAGACTAATGTATCACAAGCAGTTCCCTCCATTTAGACTA
TTCAAAAATTTAGAAGAGTGGCAAATACTATTTTAAAAGAAGAACCAAGAACTGTAAAACATATAGAAAAGAGCAAGAATGCACATGTAT
AAAGTTTACATAAAGAAGTTTTTTTAAGTTATTGAGATAGGAAATATATTCACTGCTGCTTTTAATTGTATTTTATCCAATTACATTTAA
TACACTAAAAAAAATCTTGTTGGAATTCTGTTATCAAGGCCCACATTCTTAAATACTGTGCATAAATTATTATGGTGTTTTGCCTATATA
TTGCTCCAAACTACTGTGTATATATGTATGTGTGTTAAATCACCAATTATATTAATCAAATGGAAATTAATTGCATGTTACTATCTGGGT
GATATATTCTTCTTTATATCTCTGACATGACATATTTTCATTAATAGTTTAAATCAGTGACCATCATAATAAAGATAAAATTTAGTTGAG
TTTTTAATGTTTACATGTTTACATCTCTAAATAAAATTTGCTTATTTGAAATGTTAATGCTCTTTAGAAAAATGACTTTCTAGTACCAAA
GGAAAACTACTTGAAAGAGCTGTAATCATATAGCTAAAGTGATAAGATAGCCTTGATTTTAAAAGCTGATTCATTAATATCAAAATACTT
TAATAAGTGTCACAGTTATTAATATGTTACATTTGTTTAGTTTCCACGTAATCTTTATCTCTACCTAGATTTAGTGAGTTTGCCTCTTTC
AGAATACTACCTCCTTTTGTTAAGGCATATTCTTTCGAAAATATAGATTCTAAATAAATAGGGGCTTATACAAAAAAGAAAATAAAAAGC
CATATATACTGCAAAGTTCCTAACTGGCTTGACTCCTGACATTGCATTTTTATTTCTATTTGTGTGAAGATGTTGTTATACTGTATTATG
GCTGATTTTCTTTTTAATATATTTAGCCAAGTGATGCACTTTATGATAATTAAACTCTTTTGTGCCAAGTTTAATTGGTGGATTTTTTTA
GTAAGTAGAGTTAGGAGAAAGAATTATGTAGTGCCTTTACTATTTCACTTTCTACAAAAGTCTCCTAGGGTCTTTGAGTCAGCTTTATGA
AAAAATGTTTGTTTATTTCAGCTTTGTGTACAGTCATTAAAAGTGCCTTGTTTCATTTTTATAGGATGAAGTTATTTATTTTCTATTTTC
ACTGTTTTGCATATTGCTGTTAATAAGCATTGTAATCATGCTGGCATTTTGCAATCCCAGTCGGTATGCTTTCTAAAAACTGAGGGAAAC
TTACTGGGGAAATAGAATAACAATCTCCATTTTTTTCTTTACTATCTAAAAGTTTATCGGTATCTTGATGTATATATATATTAAGGTGTG
GCTGTTTAAAATTCTAATGACATATATCAACACATTCAATGGCTGTTGTTAACCTTTGAAGTAAAAAGGAGATCACTTTTTACCAAATAA
CCAAAAATTTTTAGTCTGTCAAAGTGCACAGGTATGTTCTCAGAACATTTTTCACAATGTGTATCAGAAATATGTTTGCTATCCTTAGAG
ACAGAAATGAATATAATAAATTGATCTGCTTATTTATTAAAATTATTATTCTAGACTTACAAAAGGCTTAAAAAGAACAATCATTTAATC
AGTACCATTCTGTATCTTATATAACAGATCTTTGCCAAATTCTAGATATTATAGTGTTGCCTGTCTGTTCTAAAGCGAACCAGCCACTTT
TTCAATCTGGCTTTTTGGAAGATTGTATTTAAAGTTCTTCAAGGATGAAGAAAAAAATCTGTTAATTAGGTAAACCACTATTATTTATAT

>72553_72553_2_RB1CC1-SNX16_RB1CC1_chr8_53568568_ENST00000025008_SNX16_chr8_82736175_ENST00000353788_length(amino acids)=1274AA_BP=
MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRPPAIPKT
TFSTENDMEIKVEESLMMPAVFHTVASRTQLALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ
SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSFPKSVEHVSPDTA
DAESGKEIRESCQSTVHQQDETTIDTKDGDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK
AIKGLEDRLYALDQMIASCGRLVNEQKELAQGFLANQKRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHV
RLKWCCFVMLHADQDGEKLQALLRLVIELLERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESFGK
LFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQ
TITDLLSEQKASVSQTSPQSASSPRMESTAGITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLD
LDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHF
SIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV
CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKE
LEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEE
SRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEK
NLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL

--------------------------------------------------------------
>72553_72553_3_RB1CC1-SNX16_RB1CC1_chr8_53568568_ENST00000025008_SNX16_chr8_82736175_ENST00000396330_length(transcript)=6828nt_BP=4345nt
GTCGACAATAACAAACCAAGCCGCGGCGGTGTCCGCGGCCCTGCCGAGCCCTCGGCGTTGCCTCAGAATCCCCCAGTCGCCTGGGCCCCT
CGGCTCTGACAGGCCGCGGCCTTCTGTCCCCCGGCCCCAGACCCAGAGCCGAGGGGCCTGCTCGCGTCCTTGTCCGCCCGGACCCCTCCC
TGCCTCCTAGAGTTCGGGGCCGCGGCGGGCGGGCGCCCGGGACGCCGGCGGTTGTGTCGGCTTAGCGGTGCCGAATGGGCGGTTGGTAAC
CGCTGCCGAGGACTAGGCGGCGGCGGAAGATGGTGCCGGGGGTCGCTGGCTCTGCTGCTGCCGCCGGCGAAGGAGGAGGCGTTGCCGGTT
TTCTGAGTTTAACCAGTAATGCCATTCAGTTGCCAATCTCAAGCAAAGCAAACATAAGCCAGTTTTAATCTACTTTTTAAGAAAAGTGGT
AGTCCTTTTCACAGTGCCTGACGTAACTGTATCAGAGGGTGAGGTATAAGCTCACAGAATTCAGATAAATCATCATGAAGTTATATGTAT
TTCTGGTTAACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCATGCCATTCAAAGCAAAT
ACAAGATTGCTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGTACCTACAGTGCTGGGA
CGGATACAAATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACTACCTTTTCGACAGAAA
ATGACATGGAAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAGCTTGCATTGGAAATGT
ATGAAGTTGCCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGGGCTGCAATCATGGCCA
ACCTGGAGGACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAGTCCATAGAAGACATCA
AGTTAAAACTTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGACATAGTTACAGAGAAT
GTTTGGGAAGACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTGGTGCTCTCTCCTGATA
TGCCTAGAACAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCAGATGCTGAAAGTGGCA
AAGAAATTAGGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGATCTGCCCTTTTTTAATG
TCTCTTTGTTAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGATTCTATGAGCAGGCTTG
ATCCAAGGATTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAAGCCATTAAAGGACTTG
AAGATCGGCTCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCTCAGGGATTTTTAGCTA
ATCAGAAGAGAGCTGAAAACTTAAAGGATGCATCTGTATTACCTGATTTATGCCTGAGTCACGCAAATCAGTTGATGATTATGTTGCAAA
ATCATAGAAAACTGTTAGATATTAAGCAGAAGTGTACCACTGCCAAACAAGAACTAGCAAATAACCTACATGTCAGACTGAAGTGGTGTT
GCTTTGTAATGCTTCATGCTGATCAAGATGGAGAGAAGTTACAAGCTTTGCTCCGCCTCGTAATAGAGCTGTTAGAAAGAGTCAAAATTG
TTGAAGCTCTTAGTACAGTTCCTCAGATGTACTGCTTAGCTGTTGTTGAGGTTGTAAGAAGAAAAATGTTCATAAAACACTACAGGGAGT
GGGCTGGTGCTTTAGTCAAAGATGGAAAGAGATTATATGAAGCAGAAAAATCAAAAAGGGAATCCTTTGGGAAATTATTTAGGAAGTCTT
TTTTAAGAAATCGTCTGTTTAGGGGACTGGACTCCTGGCCCCCTTCCTTTTGTACTCAAAAGCCTCGAAAGTTTGACTGTGAACTTCCAG
ATATTTCATTAAAAGATTTACAGTTTCTGCAATCATTTTGTCCTTCGGAAGTTCAGCCATTCCTCAGGGTTCCCTTACTTTGTGACTTTG
AACCTCTACACCAGCATGTACTTGCTCTACATAATTTGGTAAAAGCAGCACAAAGTTTGGATGAAATGTCACAGACCATTACAGATCTAC
TGAGTGAACAAAAGGCATCTGTGAGTCAGACATCCCCACAGTCTGCTTCTTCACCAAGGATGGAAAGTACAGCAGGAATTACAACTACTA
CCTCACCGAGAACTCCTCCACCACTGACTGTTCAGGATCCCTTATGTCCTGCAGTTTGTCCCTTAGAAGAATTATCTCCAGATAGTATTG
ATGCACATACGTTTGATTTTGAAACTATTCCCCATCCAAACATAGAACAGACTATTCACCAAGTTTCTTTAGACTTGGATTCATTAGCAG
AAAGTCCTGAATCAGATTTTATGTCTGCTGTGAATGAGTTTGTAATAGAAGAAAATTTGTCGTCTCCTAATCCTATAAGTGATCCACAAA
GCCCAGAAATGATGGTGGAATCACTTTATTCATCAGTTATCAATGCGATAGACAGTAGACGAATGCAGGATACAAATGTATGTGGTAAGG
AGGATTTTGGAGATCATACTTCTCTGAATGTCCAGTTGGAAAGATGTAGAGTTGTTGCCCAAGACTCTCACTTCAGTATACAAACCATTA
AGGAAGACCTTTGCCACTTTAGAACATTTGTACAAAAAGAACAGTGTGACTTCTCAAATTCATTAAAATGTACAGCAGTAGAAATAAGAA
ACATTATTGAAAAAGTAAAATGTTCTCTGGAAATAACACTAAAAGAAAAACATCAAAAAGAACTACTGTCTTTAAAAAATGAATATGAAG
GTAAACTTGACGGACTAATAAAGGAAACTGAAGAGAATGAAAACAAAATTAAAAAATTGAAGGGAGAGTTAGTATGCCTTGAGGAGGTTT
TACAAAATAAAGATAATGAATTTGCTTTGGTTAAACATGAAAAAGAAGCTGTAATCTGCCTGCAGAATGAAAAGGATCAGAAGTTGTTAG
AGATGGAAAATATAATGCACTCTCAAAATTGTGAAATTAAAGAACTGAAGCAGTCACGAGAAATAGTGTTAGAAGACTTAAAAAAGCTCC
ATGTTGAAAATGATGAGAAGTTACAGTTATTGAGGGCAGAACTTCAGTCCTTGGAGCAAAGTCATCTAAAGGAATTAGAGGACACACTTC
AGGTTAGGCACATACAAGAGTTTGAGAAGGTTATGACAGACCACAGAGTTTCTTTGGAGGAATTAAAAAAGGAAAACCAACAAATAATTA
ATCAAATACAAGAATCTCATGCTGAAATTATCCAGGAAAAAGAAAAACAGTTACAGGAATTAAAACTCAAGGTTTCTGATTTGTCAGACA
CGAGATGCAAGTTAGAGGTTGAACTTGCGTTGAAGGAAGCAGAAACTGATGAAATAAAAATTTTGCTGGAAGAAAGCAGAGCCCAGCAGA
AGGAGACCTTGAAATCTCTTCTTGAACAAGAGACAGAAAATTTGAGAACAGAAATTAGTAAACTCAACCAAAAGATTCAGGATAATAATG
AAAATTATCAGGTGGGCTTAGCAGAGCTAAGAACTTTAATGACAATTGAAAAAGATCAGTGTATTTCCGAGTTAATTAGTAGACATGAAG
AAGAATCTAATATACTTAAAGCTGAATTAAACAAAGTAACATCTTTGCATAACCAAGCATTTGAAATAGAAAAAAACCTAAAAGAACAAA
TAATTGAACTGCAGAGTAAATTGGATTCAGAATTGAGTGCTCTTGAAAGACAAAAAGATGAAAAAATTACCCAACAAGAAGAGAAATACG
AAGCTATTATCCAGAACCTTGAGAAAGACAGACAAAAATTGGTCAGCAGCCAGGAGCAAGACAGAGAACAGTTAATTCAGAAGCTTAATT
GTGAAAAAGATGAAGCTATTCAGACTGCCCTAAAAGAATTTAAATTGGAGAGAGAAGTTGTTGAGAAAGAGTTATTAGAAAAAGTTAAAC
ATCTTGAGAATCAAATAGCAAAAAGTTAAAAGAGATGTTTCCAGGTTTTCGACTAGCACTTCCTCCAAAACGCTGGTTTAAAGATAATTA
CAATGCTGACTTTTTAGAAGACAGACAATTAGGATTACAAGCGTTTCTTCAAAATTTAGTAGCTCACAAGGACATTGCTAACTGCCTTGC
AGTGAGAGAATTTCTTTGTTTGGATGATCCACCGGGTCCATTTGATAGCCTAGAAGAAAGCAGGGCATTCTGTGAAACTTTAGAAGAGAC
AAACTACCGCTTACAGAAAGAACTACTTGAAAAACAAAAGGAGATGGAATCACTAAAGAAACTGCTCAGTGAGAAGCAACTTCATATAGA
CACTTTAGAGAACAGAATCAGAACATTGTCTTTAGAACCTGAAGAATCACTGGATGTGTCAGAAACAGAAGGTGAACAGATCCTAAAGGT
GGAGTCCTCTGCACTTGAGGTTGATCAAGATGTCCTGGATGAAGAATCTAGAGCTGATAATAAACCATGCTTAAGTTTTAGTGAACCTGA
AAATGCTGTATCAGAGATAGAAGTAGCAGAAGTGGCATATGATGCTGAAGAAGACTAATGTATCACAAGCAGTTCCCTCCATTTAGACTA
TTCAAAAATTTAGAAGAGTGGCAAATACTATTTTAAAAGAAGAACCAAGAACTGTAAAACATATAGAAAAGAGCAAGAATGCACATGTAT
AAAGTTTACATAAAGAAGTTTTTTTAAGTTATTGAGATAGGAAATATATTCACTGCTGCTTTTAATTGTATTTTATCCAATTACATTTAA
TACACTAAAAAAAATCTTGTTGGAATTCTGTTATCAAGGCCCACATTCTTAAATACTGTGCATAAATTATTATGGTGTTTTGCCTATATA
TTGCTCCAAACTACTGTGTATATATGTATGTGTGTTAAATCACCAATTATATTAATCAAATGGAAATTAATTGCATGTTACTATCTGGGT
GATATATTCTTCTTTATATCTCTGACATGACATATTTTCATTAATAGTTTAAATCAGTGACCATCATAATAAAGATAAAATTTAGTTGAG
TTTTTAATGTTTACATGTTTACATCTCTAAATAAAATTTGCTTATTTGAAATGTTAATGCTCTTTAGAAAAATGACTTTCTAGTACCAAA
GGAAAACTACTTGAAAGAGCTGTAATCATATAGCTAAAGTGATAAGATAGCCTTGATTTTAAAAGCTGATTCATTAATATCAAAATACTT
TAATAAGTGTCACAGTTATTAATATGTTACATTTGTTTAGTTTCCACGTAATCTTTATCTCTACCTAGATTTAGTGAGTTTGCCTCTTTC
AGAATACTACCTCCTTTTGTTAAGGCATATTCTTTCGAAAATATAGATTCTAAATAAATAGGGGCTTATACAAAAAAGAAAATAAAAAGC
CATATATACTGCAAAGTTCCTAACTGGCTTGACTCCTGACATTGCATTTTTATTTCTATTTGTGTGAAGATGTTGTTATACTGTATTATG
GCTGATTTTCTTTTTAATATATTTAGCCAAGTGATGCACTTTATGATAATTAAACTCTTTTGTGCCAAGTTTAATTGGTGGATTTTTTTA
GTAAGTAGAGTTAGGAGAAAGAATTATGTAGTGCCTTTACTATTTCACTTTCTACAAAAGTCTCCTAGGGTCTTTGAGTCAGCTTTATGA
AAAAATGTTTGTTTATTTCAGCTTTGTGTACAGTCATTAAAAGTGCCTTGTTTCATTTTTATAGGATGAAGTTATTTATTTTCTATTTTC
ACTGTTTTGCATATTGCTGTTAATAAGCATTGTAATCATGCTGGCATTTTGCAATCCCAGTCGGTATGCTTTCTAAAAACTGAGGGAAAC
TTACTGGGGAAATAGAATAACAATCTCCATTTTTTTCTTTACTATCTAAAAGTTTATCGGTATCTTGATGTATATATATATTAAGGTGTG
GCTGTTTAAAATTCTAATGACATATATCAACACATTCAATGGCTGTTGTTAACCTTTGAAGTAAAAAGGAGATCACTTTTTACCAAATAA
CCAAAAATTTTTAGTCTGTCAAAGTGCACAGGTATGTTCTCAGAACATTTTTCACAATGTGTATCAGAAATATGTTTGCTATCCTTAGAG
ACAGAAATGAATATAATAAATTGATCTGCTTATTTATTAAAATTATTATTCTAGACTTACAAAAGGCTTAAAAAGAACAATCATTTAATC
AGTACCATTCTGTATCTTATATAACAGATCTTTGCCAAATTCTAGATATTATAGTGTTGCCTGTCTGTTCTAAAGCGAACCAGCCACTTT
TTCAATCTGGCTTTTTGGAAGATTGTATTTAAAGTTCTTCAAGGATGAAGAAAAAAATCTGTTAATTAGGTAAACCACTATTATTTATAT

>72553_72553_3_RB1CC1-SNX16_RB1CC1_chr8_53568568_ENST00000025008_SNX16_chr8_82736175_ENST00000396330_length(amino acids)=1274AA_BP=
MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRPPAIPKT
TFSTENDMEIKVEESLMMPAVFHTVASRTQLALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ
SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSFPKSVEHVSPDTA
DAESGKEIRESCQSTVHQQDETTIDTKDGDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK
AIKGLEDRLYALDQMIASCGRLVNEQKELAQGFLANQKRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHV
RLKWCCFVMLHADQDGEKLQALLRLVIELLERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESFGK
LFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQ
TITDLLSEQKASVSQTSPQSASSPRMESTAGITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLD
LDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHF
SIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV
CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKE
LEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEE
SRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEK
NLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL

--------------------------------------------------------------
>72553_72553_4_RB1CC1-SNX16_RB1CC1_chr8_53568568_ENST00000435644_SNX16_chr8_82736175_ENST00000345957_length(transcript)=5448nt_BP=4336nt
AACAAACCAAGCCGCGGCGGTGTCCGCGGCCCTGCCGAGCCCTCGGCGTTGCCTCAGAATCCCCCAGTCGCCTGGGCCCCTCGGCTCTGA
CAGGCCGCGGCCTTCTGTCCCCCGGCCCCAGACCCAGAGCCGAGGGGCCTGCTCGCGTCCTTGTCCGCCCGGACCCCTCCCTGCCTCCTA
GAGTTCGGGGCCGCGGCGGGCGGGCGCCCGGGACGCCGGCGGTTGTGTCGGCTTAGCGGTGCCGAATGGGCGGTTGGTAACCGCTGCCGA
GGACTAGGCGGCGGCGGAAGATGGTGCCGGGGGTCGCTGGCTCTGCTGCTGCCGCCGGCGAAGGAGGAGGCGTTGCCGGTTTTCTGAGTT
TAACCAGTAATGCCATTCAGTTGCCAATCTCAAGCAAAGCAAACATAAGCCAGTTTTAATCTACTTTTTAAGAAAAGTGGTAGTCCTTTT
CACAGTGCCTGACGTAACTGTATCAGAGGGTGAGGTATAAGCTCACAGAATTCAGATAAATCATCATGAAGTTATATGTATTTCTGGTTA
ACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCATGCCATTCAAAGCAAATACAAGATTG
CTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGTACCTACAGTGCTGGGACGGATACAA
ATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACTACCTTTTCGACAGAAAATGACATGG
AAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAGCTTGCATTGGAAATGTATGAAGTTG
CCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGGGCTGCAATCATGGCCAACCTGGAGG
ACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAGTCCATAGAAGACATCAAGTTAAAAC
TTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGACATAGTTACAGAGAATGTTTGGGAA
GACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTGGTGCTCTCTCCTGATATGCCTAGAA
CAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCAGATGCTGAAAGTGGCAAAGAAATTA
GGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGATCTGCCCTTTTTTAATGTCTCTTTGT
TAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGATTCTATGAGCAGGCTTGATCCAAGGA
TTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAAGCCATTAAAGGACTTGAAGATCGGC
TCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCTCAGGGATTTTTAGCTAATCAGAAGA
GAGCTGAAAACTTAAAGGATGCATCTGTATTACCTGATTTATGCCTGAGTCACGCAAATCAGTTGATGATTATGTTGCAAAATCATAGAA
AACTGTTAGATATTAAGCAGAAGTGTACCACTGCCAAACAAGAACTAGCAAATAACCTACATGTCAGACTGAAGTGGTGTTGCTTTGTAA
TGCTTCATGCTGATCAAGATGGAGAGAAGTTACAAGCTTTGCTCCGCCTCGTAATAGAGCTGTTAGAAAGAGTCAAAATTGTTGAAGCTC
TTAGTACAGTTCCTCAGATGTACTGCTTAGCTGTTGTTGAGGTTGTAAGAAGAAAAATGTTCATAAAACACTACAGGGAGTGGGCTGGTG
CTTTAGTCAAAGATGGAAAGAGATTATATGAAGCAGAAAAATCAAAAAGGGAATCCTTTGGGAAATTATTTAGGAAGTCTTTTTTAAGAA
ATCGTCTGTTTAGGGGACTGGACTCCTGGCCCCCTTCCTTTTGTACTCAAAAGCCTCGAAAGTTTGACTGTGAACTTCCAGATATTTCAT
TAAAAGATTTACAGTTTCTGCAATCATTTTGTCCTTCGGAAGTTCAGCCATTCCTCAGGGTTCCCTTACTTTGTGACTTTGAACCTCTAC
ACCAGCATGTACTTGCTCTACATAATTTGGTAAAAGCAGCACAAAGTTTGGATGAAATGTCACAGACCATTACAGATCTACTGAGTGAAC
AAAAGGCATCTGTGAGTCAGACATCCCCACAGTCTGCTTCTTCACCAAGGATGGAAAGTACAGCAGGAATTACAACTACTACCTCACCGA
GAACTCCTCCACCACTGACTGTTCAGGATCCCTTATGTCCTGCAGTTTGTCCCTTAGAAGAATTATCTCCAGATAGTATTGATGCACATA
CGTTTGATTTTGAAACTATTCCCCATCCAAACATAGAACAGACTATTCACCAAGTTTCTTTAGACTTGGATTCATTAGCAGAAAGTCCTG
AATCAGATTTTATGTCTGCTGTGAATGAGTTTGTAATAGAAGAAAATTTGTCGTCTCCTAATCCTATAAGTGATCCACAAAGCCCAGAAA
TGATGGTGGAATCACTTTATTCATCAGTTATCAATGCGATAGACAGTAGACGAATGCAGGATACAAATGTATGTGGTAAGGAGGATTTTG
GAGATCATACTTCTCTGAATGTCCAGTTGGAAAGATGTAGAGTTGTTGCCCAAGACTCTCACTTCAGTATACAAACCATTAAGGAAGACC
TTTGCCACTTTAGAACATTTGTACAAAAAGAACAGTGTGACTTCTCAAATTCATTAAAATGTACAGCAGTAGAAATAAGAAACATTATTG
AAAAAGTAAAATGTTCTCTGGAAATAACACTAAAAGAAAAACATCAAAAAGAACTACTGTCTTTAAAAAATGAATATGAAGGTAAACTTG
ACGGACTAATAAAGGAAACTGAAGAGAATGAAAACAAAATTAAAAAATTGAAGGGAGAGTTAGTATGCCTTGAGGAGGTTTTACAAAATA
AAGATAATGAATTTGCTTTGGTTAAACATGAAAAAGAAGCTGTAATCTGCCTGCAGAATGAAAAGGATCAGAAGTTGTTAGAGATGGAAA
ATATAATGCACTCTCAAAATTGTGAAATTAAAGAACTGAAGCAGTCACGAGAAATAGTGTTAGAAGACTTAAAAAAGCTCCATGTTGAAA
ATGATGAGAAGTTACAGTTATTGAGGGCAGAACTTCAGTCCTTGGAGCAAAGTCATCTAAAGGAATTAGAGGACACACTTCAGGTTAGGC
ACATACAAGAGTTTGAGAAGGTTATGACAGACCACAGAGTTTCTTTGGAGGAATTAAAAAAGGAAAACCAACAAATAATTAATCAAATAC
AAGAATCTCATGCTGAAATTATCCAGGAAAAAGAAAAACAGTTACAGGAATTAAAACTCAAGGTTTCTGATTTGTCAGACACGAGATGCA
AGTTAGAGGTTGAACTTGCGTTGAAGGAAGCAGAAACTGATGAAATAAAAATTTTGCTGGAAGAAAGCAGAGCCCAGCAGAAGGAGACCT
TGAAATCTCTTCTTGAACAAGAGACAGAAAATTTGAGAACAGAAATTAGTAAACTCAACCAAAAGATTCAGGATAATAATGAAAATTATC
AGGTGGGCTTAGCAGAGCTAAGAACTTTAATGACAATTGAAAAAGATCAGTGTATTTCCGAGTTAATTAGTAGACATGAAGAAGAATCTA
ATATACTTAAAGCTGAATTAAACAAAGTAACATCTTTGCATAACCAAGCATTTGAAATAGAAAAAAACCTAAAAGAACAAATAATTGAAC
TGCAGAGTAAATTGGATTCAGAATTGAGTGCTCTTGAAAGACAAAAAGATGAAAAAATTACCCAACAAGAAGAGAAATACGAAGCTATTA
TCCAGAACCTTGAGAAAGACAGACAAAAATTGGTCAGCAGCCAGGAGCAAGACAGAGAACAGTTAATTCAGAAGCTTAATTGTGAAAAAG
ATGAAGCTATTCAGACTGCCCTAAAAGAATTTAAATTGGAGAGAGAAGTTGTTGAGAAAGAGTTATTAGAAAAAGTTAAACATCTTGAGA
ATCAAATAGCAAAAAGTTAAAAGAGATGTTTCCAGGTTTTCGACTAGCACTTCCTCCAAAACGCTGGTTTAAAGATAATTACAATGCTGA
CTTTTTAGAAGACAGACAATTAGGATTACAAGCGTTTCTTCAAAATTTAGTAGCTCACAAGGACATTGCTAACTGCCTTGCAGTGAGAGA
ATTTCTTTGTTTGGATGATCCACCGGGTCCATTTGATAGCCTAGAAGAAAGCAGGGCATTCTGTGAAACTTTAGAAGAGACAAACTACCG
CTTACAGAAAGAACTACTTGAAAAACAAAAGGAGATGGAATCACTAAAGAAACTGCTCAGTGAGAAGCAACTTCATATAGACACTTTAGA
GAACAGAATCAGAACATTGTCTTTAGAACCTGAAGAATCACTGGATGTGTCAGAAACAGAAGGTGAACAGATCCTAAAGGTGGAGTCCTC
TGCACTTGAGGTTGATCAAGATGTCCTGGATGAAGAATCTAGAGCTGATAATAAACCATGCTTAAGTTTTAGTGAACCTGAAAATGCTGT
ATCAGAGATAGAAGTAGCAGAAGTGGCATATGATGCTGAAGAAGACTAATGTATCACAAGCAGTTCCCTCCATTTAGACTATTCAAAAAT
TTAGAAGAGTGGCAAATACTATTTTAAAAGAAGAACCAAGAACTGTAAAACATATAGAAAAGAGCAAGAATGCACATGTATAAAGTTTAC
ATAAAGAAGTTTTTTTAAGTTATTGAGATAGGAAATATATTCACTGCTGCTTTTAATTGTATTTTATCCAATTACATTTAATACACTAAA
AAAAATCTTGTTGGAATTCTGTTATCAAGGCCCACATTCTTAAATACTGTGCATAAATTATTATGGTGTTTTGCCTATATATTGCTCCAA
ACTACTGTGTATATATGTATGTGTGTTAAATCACCAATTATATTAATCAAATGGAAATTAATTGCATGTTACTATCTGGGTGATATATTC
TTCTTTATATCTCTGACATGACATATTTTCATTAATAGTTTAAATCAGTGACCATCATAATAAAGATAAAATTTAGTTGAGTTTTTAATG

>72553_72553_4_RB1CC1-SNX16_RB1CC1_chr8_53568568_ENST00000435644_SNX16_chr8_82736175_ENST00000345957_length(amino acids)=1274AA_BP=
MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRPPAIPKT
TFSTENDMEIKVEESLMMPAVFHTVASRTQLALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ
SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSFPKSVEHVSPDTA
DAESGKEIRESCQSTVHQQDETTIDTKDGDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK
AIKGLEDRLYALDQMIASCGRLVNEQKELAQGFLANQKRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHV
RLKWCCFVMLHADQDGEKLQALLRLVIELLERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESFGK
LFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQ
TITDLLSEQKASVSQTSPQSASSPRMESTAGITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLD
LDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHF
SIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV
CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKE
LEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEE
SRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEK
NLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL

--------------------------------------------------------------
>72553_72553_5_RB1CC1-SNX16_RB1CC1_chr8_53568568_ENST00000435644_SNX16_chr8_82736175_ENST00000353788_length(transcript)=6825nt_BP=4336nt
AACAAACCAAGCCGCGGCGGTGTCCGCGGCCCTGCCGAGCCCTCGGCGTTGCCTCAGAATCCCCCAGTCGCCTGGGCCCCTCGGCTCTGA
CAGGCCGCGGCCTTCTGTCCCCCGGCCCCAGACCCAGAGCCGAGGGGCCTGCTCGCGTCCTTGTCCGCCCGGACCCCTCCCTGCCTCCTA
GAGTTCGGGGCCGCGGCGGGCGGGCGCCCGGGACGCCGGCGGTTGTGTCGGCTTAGCGGTGCCGAATGGGCGGTTGGTAACCGCTGCCGA
GGACTAGGCGGCGGCGGAAGATGGTGCCGGGGGTCGCTGGCTCTGCTGCTGCCGCCGGCGAAGGAGGAGGCGTTGCCGGTTTTCTGAGTT
TAACCAGTAATGCCATTCAGTTGCCAATCTCAAGCAAAGCAAACATAAGCCAGTTTTAATCTACTTTTTAAGAAAAGTGGTAGTCCTTTT
CACAGTGCCTGACGTAACTGTATCAGAGGGTGAGGTATAAGCTCACAGAATTCAGATAAATCATCATGAAGTTATATGTATTTCTGGTTA
ACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCATGCCATTCAAAGCAAATACAAGATTG
CTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGTACCTACAGTGCTGGGACGGATACAA
ATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACTACCTTTTCGACAGAAAATGACATGG
AAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAGCTTGCATTGGAAATGTATGAAGTTG
CCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGGGCTGCAATCATGGCCAACCTGGAGG
ACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAGTCCATAGAAGACATCAAGTTAAAAC
TTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGACATAGTTACAGAGAATGTTTGGGAA
GACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTGGTGCTCTCTCCTGATATGCCTAGAA
CAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCAGATGCTGAAAGTGGCAAAGAAATTA
GGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGATCTGCCCTTTTTTAATGTCTCTTTGT
TAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGATTCTATGAGCAGGCTTGATCCAAGGA
TTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAAGCCATTAAAGGACTTGAAGATCGGC
TCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCTCAGGGATTTTTAGCTAATCAGAAGA
GAGCTGAAAACTTAAAGGATGCATCTGTATTACCTGATTTATGCCTGAGTCACGCAAATCAGTTGATGATTATGTTGCAAAATCATAGAA
AACTGTTAGATATTAAGCAGAAGTGTACCACTGCCAAACAAGAACTAGCAAATAACCTACATGTCAGACTGAAGTGGTGTTGCTTTGTAA
TGCTTCATGCTGATCAAGATGGAGAGAAGTTACAAGCTTTGCTCCGCCTCGTAATAGAGCTGTTAGAAAGAGTCAAAATTGTTGAAGCTC
TTAGTACAGTTCCTCAGATGTACTGCTTAGCTGTTGTTGAGGTTGTAAGAAGAAAAATGTTCATAAAACACTACAGGGAGTGGGCTGGTG
CTTTAGTCAAAGATGGAAAGAGATTATATGAAGCAGAAAAATCAAAAAGGGAATCCTTTGGGAAATTATTTAGGAAGTCTTTTTTAAGAA
ATCGTCTGTTTAGGGGACTGGACTCCTGGCCCCCTTCCTTTTGTACTCAAAAGCCTCGAAAGTTTGACTGTGAACTTCCAGATATTTCAT
TAAAAGATTTACAGTTTCTGCAATCATTTTGTCCTTCGGAAGTTCAGCCATTCCTCAGGGTTCCCTTACTTTGTGACTTTGAACCTCTAC
ACCAGCATGTACTTGCTCTACATAATTTGGTAAAAGCAGCACAAAGTTTGGATGAAATGTCACAGACCATTACAGATCTACTGAGTGAAC
AAAAGGCATCTGTGAGTCAGACATCCCCACAGTCTGCTTCTTCACCAAGGATGGAAAGTACAGCAGGAATTACAACTACTACCTCACCGA
GAACTCCTCCACCACTGACTGTTCAGGATCCCTTATGTCCTGCAGTTTGTCCCTTAGAAGAATTATCTCCAGATAGTATTGATGCACATA
CGTTTGATTTTGAAACTATTCCCCATCCAAACATAGAACAGACTATTCACCAAGTTTCTTTAGACTTGGATTCATTAGCAGAAAGTCCTG
AATCAGATTTTATGTCTGCTGTGAATGAGTTTGTAATAGAAGAAAATTTGTCGTCTCCTAATCCTATAAGTGATCCACAAAGCCCAGAAA
TGATGGTGGAATCACTTTATTCATCAGTTATCAATGCGATAGACAGTAGACGAATGCAGGATACAAATGTATGTGGTAAGGAGGATTTTG
GAGATCATACTTCTCTGAATGTCCAGTTGGAAAGATGTAGAGTTGTTGCCCAAGACTCTCACTTCAGTATACAAACCATTAAGGAAGACC
TTTGCCACTTTAGAACATTTGTACAAAAAGAACAGTGTGACTTCTCAAATTCATTAAAATGTACAGCAGTAGAAATAAGAAACATTATTG
AAAAAGTAAAATGTTCTCTGGAAATAACACTAAAAGAAAAACATCAAAAAGAACTACTGTCTTTAAAAAATGAATATGAAGGTAAACTTG
ACGGACTAATAAAGGAAACTGAAGAGAATGAAAACAAAATTAAAAAATTGAAGGGAGAGTTAGTATGCCTTGAGGAGGTTTTACAAAATA
AAGATAATGAATTTGCTTTGGTTAAACATGAAAAAGAAGCTGTAATCTGCCTGCAGAATGAAAAGGATCAGAAGTTGTTAGAGATGGAAA
ATATAATGCACTCTCAAAATTGTGAAATTAAAGAACTGAAGCAGTCACGAGAAATAGTGTTAGAAGACTTAAAAAAGCTCCATGTTGAAA
ATGATGAGAAGTTACAGTTATTGAGGGCAGAACTTCAGTCCTTGGAGCAAAGTCATCTAAAGGAATTAGAGGACACACTTCAGGTTAGGC
ACATACAAGAGTTTGAGAAGGTTATGACAGACCACAGAGTTTCTTTGGAGGAATTAAAAAAGGAAAACCAACAAATAATTAATCAAATAC
AAGAATCTCATGCTGAAATTATCCAGGAAAAAGAAAAACAGTTACAGGAATTAAAACTCAAGGTTTCTGATTTGTCAGACACGAGATGCA
AGTTAGAGGTTGAACTTGCGTTGAAGGAAGCAGAAACTGATGAAATAAAAATTTTGCTGGAAGAAAGCAGAGCCCAGCAGAAGGAGACCT
TGAAATCTCTTCTTGAACAAGAGACAGAAAATTTGAGAACAGAAATTAGTAAACTCAACCAAAAGATTCAGGATAATAATGAAAATTATC
AGGTGGGCTTAGCAGAGCTAAGAACTTTAATGACAATTGAAAAAGATCAGTGTATTTCCGAGTTAATTAGTAGACATGAAGAAGAATCTA
ATATACTTAAAGCTGAATTAAACAAAGTAACATCTTTGCATAACCAAGCATTTGAAATAGAAAAAAACCTAAAAGAACAAATAATTGAAC
TGCAGAGTAAATTGGATTCAGAATTGAGTGCTCTTGAAAGACAAAAAGATGAAAAAATTACCCAACAAGAAGAGAAATACGAAGCTATTA
TCCAGAACCTTGAGAAAGACAGACAAAAATTGGTCAGCAGCCAGGAGCAAGACAGAGAACAGTTAATTCAGAAGCTTAATTGTGAAAAAG
ATGAAGCTATTCAGACTGCCCTAAAAGAATTTAAATTGGAGAGAGAAGTTGTTGAGAAAGAGTTATTAGAAAAAGTTAAACATCTTGAGA
ATCAAATAGCAAAAAGTTAAAAGAGATGTTTCCAGGTTTTCGACTAGCACTTCCTCCAAAACGCTGGTTTAAAGATAATTACAATGCTGA
CTTTTTAGAAGACAGACAATTAGGATTACAAGCGTTTCTTCAAAATTTAGTAGCTCACAAGGACATTGCTAACTGCCTTGCAGTGAGAGA
ATTTCTTTGTTTGGATGATCCACCGGGTCCATTTGATAGCCTAGAAGAAAGCAGGGCATTCTGTGAAACTTTAGAAGAGACAAACTACCG
CTTACAGAAAGAACTACTTGAAAAACAAAAGGAGATGGAATCACTAAAGAAACTGCTCAGTGAGAAGCAACTTCATATAGACACTTTAGA
GAACAGAATCAGAACATTGTCTTTAGAACCTGAAGAATCACTGGATGTGTCAGAAACAGAAGGTGAACAGATCCTAAAGGTGGAGTCCTC
TGCACTTGAGGTTGATCAAGATGTCCTGGATGAAGAATCTAGAGCTGATAATAAACCATGCTTAAGTTTTAGTGAACCTGAAAATGCTGT
ATCAGAGATAGAAGTAGCAGAAGTGGCATATGATGCTGAAGAAGACTAATGTATCACAAGCAGTTCCCTCCATTTAGACTATTCAAAAAT
TTAGAAGAGTGGCAAATACTATTTTAAAAGAAGAACCAAGAACTGTAAAACATATAGAAAAGAGCAAGAATGCACATGTATAAAGTTTAC
ATAAAGAAGTTTTTTTAAGTTATTGAGATAGGAAATATATTCACTGCTGCTTTTAATTGTATTTTATCCAATTACATTTAATACACTAAA
AAAAATCTTGTTGGAATTCTGTTATCAAGGCCCACATTCTTAAATACTGTGCATAAATTATTATGGTGTTTTGCCTATATATTGCTCCAA
ACTACTGTGTATATATGTATGTGTGTTAAATCACCAATTATATTAATCAAATGGAAATTAATTGCATGTTACTATCTGGGTGATATATTC
TTCTTTATATCTCTGACATGACATATTTTCATTAATAGTTTAAATCAGTGACCATCATAATAAAGATAAAATTTAGTTGAGTTTTTAATG
TTTACATGTTTACATCTCTAAATAAAATTTGCTTATTTGAAATGTTAATGCTCTTTAGAAAAATGACTTTCTAGTACCAAAGGAAAACTA
CTTGAAAGAGCTGTAATCATATAGCTAAAGTGATAAGATAGCCTTGATTTTAAAAGCTGATTCATTAATATCAAAATACTTTAATAAGTG
TCACAGTTATTAATATGTTACATTTGTTTAGTTTCCACGTAATCTTTATCTCTACCTAGATTTAGTGAGTTTGCCTCTTTCAGAATACTA
CCTCCTTTTGTTAAGGCATATTCTTTCGAAAATATAGATTCTAAATAAATAGGGGCTTATACAAAAAAGAAAATAAAAAGCCATATATAC
TGCAAAGTTCCTAACTGGCTTGACTCCTGACATTGCATTTTTATTTCTATTTGTGTGAAGATGTTGTTATACTGTATTATGGCTGATTTT
CTTTTTAATATATTTAGCCAAGTGATGCACTTTATGATAATTAAACTCTTTTGTGCCAAGTTTAATTGGTGGATTTTTTTAGTAAGTAGA
GTTAGGAGAAAGAATTATGTAGTGCCTTTACTATTTCACTTTCTACAAAAGTCTCCTAGGGTCTTTGAGTCAGCTTTATGAAAAAATGTT
TGTTTATTTCAGCTTTGTGTACAGTCATTAAAAGTGCCTTGTTTCATTTTTATAGGATGAAGTTATTTATTTTCTATTTTCACTGTTTTG
CATATTGCTGTTAATAAGCATTGTAATCATGCTGGCATTTTGCAATCCCAGTCGGTATGCTTTCTAAAAACTGAGGGAAACTTACTGGGG
AAATAGAATAACAATCTCCATTTTTTTCTTTACTATCTAAAAGTTTATCGGTATCTTGATGTATATATATATTAAGGTGTGGCTGTTTAA
AATTCTAATGACATATATCAACACATTCAATGGCTGTTGTTAACCTTTGAAGTAAAAAGGAGATCACTTTTTACCAAATAACCAAAAATT
TTTAGTCTGTCAAAGTGCACAGGTATGTTCTCAGAACATTTTTCACAATGTGTATCAGAAATATGTTTGCTATCCTTAGAGACAGAAATG
AATATAATAAATTGATCTGCTTATTTATTAAAATTATTATTCTAGACTTACAAAAGGCTTAAAAAGAACAATCATTTAATCAGTACCATT
CTGTATCTTATATAACAGATCTTTGCCAAATTCTAGATATTATAGTGTTGCCTGTCTGTTCTAAAGCGAACCAGCCACTTTTTCAATCTG
GCTTTTTGGAAGATTGTATTTAAAGTTCTTCAAGGATGAAGAAAAAAATCTGTTAATTAGGTAAACCACTATTATTTATATTTATAATTT

>72553_72553_5_RB1CC1-SNX16_RB1CC1_chr8_53568568_ENST00000435644_SNX16_chr8_82736175_ENST00000353788_length(amino acids)=1274AA_BP=
MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRPPAIPKT
TFSTENDMEIKVEESLMMPAVFHTVASRTQLALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ
SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSFPKSVEHVSPDTA
DAESGKEIRESCQSTVHQQDETTIDTKDGDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK
AIKGLEDRLYALDQMIASCGRLVNEQKELAQGFLANQKRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHV
RLKWCCFVMLHADQDGEKLQALLRLVIELLERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESFGK
LFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQ
TITDLLSEQKASVSQTSPQSASSPRMESTAGITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLD
LDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHF
SIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV
CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKE
LEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEE
SRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEK
NLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL

--------------------------------------------------------------
>72553_72553_6_RB1CC1-SNX16_RB1CC1_chr8_53568568_ENST00000435644_SNX16_chr8_82736175_ENST00000396330_length(transcript)=6819nt_BP=4336nt
AACAAACCAAGCCGCGGCGGTGTCCGCGGCCCTGCCGAGCCCTCGGCGTTGCCTCAGAATCCCCCAGTCGCCTGGGCCCCTCGGCTCTGA
CAGGCCGCGGCCTTCTGTCCCCCGGCCCCAGACCCAGAGCCGAGGGGCCTGCTCGCGTCCTTGTCCGCCCGGACCCCTCCCTGCCTCCTA
GAGTTCGGGGCCGCGGCGGGCGGGCGCCCGGGACGCCGGCGGTTGTGTCGGCTTAGCGGTGCCGAATGGGCGGTTGGTAACCGCTGCCGA
GGACTAGGCGGCGGCGGAAGATGGTGCCGGGGGTCGCTGGCTCTGCTGCTGCCGCCGGCGAAGGAGGAGGCGTTGCCGGTTTTCTGAGTT
TAACCAGTAATGCCATTCAGTTGCCAATCTCAAGCAAAGCAAACATAAGCCAGTTTTAATCTACTTTTTAAGAAAAGTGGTAGTCCTTTT
CACAGTGCCTGACGTAACTGTATCAGAGGGTGAGGTATAAGCTCACAGAATTCAGATAAATCATCATGAAGTTATATGTATTTCTGGTTA
ACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCATGCCATTCAAAGCAAATACAAGATTG
CTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGTACCTACAGTGCTGGGACGGATACAA
ATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACTACCTTTTCGACAGAAAATGACATGG
AAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAGCTTGCATTGGAAATGTATGAAGTTG
CCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGGGCTGCAATCATGGCCAACCTGGAGG
ACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAGTCCATAGAAGACATCAAGTTAAAAC
TTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGACATAGTTACAGAGAATGTTTGGGAA
GACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTGGTGCTCTCTCCTGATATGCCTAGAA
CAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCAGATGCTGAAAGTGGCAAAGAAATTA
GGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGATCTGCCCTTTTTTAATGTCTCTTTGT
TAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGATTCTATGAGCAGGCTTGATCCAAGGA
TTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAAGCCATTAAAGGACTTGAAGATCGGC
TCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCTCAGGGATTTTTAGCTAATCAGAAGA
GAGCTGAAAACTTAAAGGATGCATCTGTATTACCTGATTTATGCCTGAGTCACGCAAATCAGTTGATGATTATGTTGCAAAATCATAGAA
AACTGTTAGATATTAAGCAGAAGTGTACCACTGCCAAACAAGAACTAGCAAATAACCTACATGTCAGACTGAAGTGGTGTTGCTTTGTAA
TGCTTCATGCTGATCAAGATGGAGAGAAGTTACAAGCTTTGCTCCGCCTCGTAATAGAGCTGTTAGAAAGAGTCAAAATTGTTGAAGCTC
TTAGTACAGTTCCTCAGATGTACTGCTTAGCTGTTGTTGAGGTTGTAAGAAGAAAAATGTTCATAAAACACTACAGGGAGTGGGCTGGTG
CTTTAGTCAAAGATGGAAAGAGATTATATGAAGCAGAAAAATCAAAAAGGGAATCCTTTGGGAAATTATTTAGGAAGTCTTTTTTAAGAA
ATCGTCTGTTTAGGGGACTGGACTCCTGGCCCCCTTCCTTTTGTACTCAAAAGCCTCGAAAGTTTGACTGTGAACTTCCAGATATTTCAT
TAAAAGATTTACAGTTTCTGCAATCATTTTGTCCTTCGGAAGTTCAGCCATTCCTCAGGGTTCCCTTACTTTGTGACTTTGAACCTCTAC
ACCAGCATGTACTTGCTCTACATAATTTGGTAAAAGCAGCACAAAGTTTGGATGAAATGTCACAGACCATTACAGATCTACTGAGTGAAC
AAAAGGCATCTGTGAGTCAGACATCCCCACAGTCTGCTTCTTCACCAAGGATGGAAAGTACAGCAGGAATTACAACTACTACCTCACCGA
GAACTCCTCCACCACTGACTGTTCAGGATCCCTTATGTCCTGCAGTTTGTCCCTTAGAAGAATTATCTCCAGATAGTATTGATGCACATA
CGTTTGATTTTGAAACTATTCCCCATCCAAACATAGAACAGACTATTCACCAAGTTTCTTTAGACTTGGATTCATTAGCAGAAAGTCCTG
AATCAGATTTTATGTCTGCTGTGAATGAGTTTGTAATAGAAGAAAATTTGTCGTCTCCTAATCCTATAAGTGATCCACAAAGCCCAGAAA
TGATGGTGGAATCACTTTATTCATCAGTTATCAATGCGATAGACAGTAGACGAATGCAGGATACAAATGTATGTGGTAAGGAGGATTTTG
GAGATCATACTTCTCTGAATGTCCAGTTGGAAAGATGTAGAGTTGTTGCCCAAGACTCTCACTTCAGTATACAAACCATTAAGGAAGACC
TTTGCCACTTTAGAACATTTGTACAAAAAGAACAGTGTGACTTCTCAAATTCATTAAAATGTACAGCAGTAGAAATAAGAAACATTATTG
AAAAAGTAAAATGTTCTCTGGAAATAACACTAAAAGAAAAACATCAAAAAGAACTACTGTCTTTAAAAAATGAATATGAAGGTAAACTTG
ACGGACTAATAAAGGAAACTGAAGAGAATGAAAACAAAATTAAAAAATTGAAGGGAGAGTTAGTATGCCTTGAGGAGGTTTTACAAAATA
AAGATAATGAATTTGCTTTGGTTAAACATGAAAAAGAAGCTGTAATCTGCCTGCAGAATGAAAAGGATCAGAAGTTGTTAGAGATGGAAA
ATATAATGCACTCTCAAAATTGTGAAATTAAAGAACTGAAGCAGTCACGAGAAATAGTGTTAGAAGACTTAAAAAAGCTCCATGTTGAAA
ATGATGAGAAGTTACAGTTATTGAGGGCAGAACTTCAGTCCTTGGAGCAAAGTCATCTAAAGGAATTAGAGGACACACTTCAGGTTAGGC
ACATACAAGAGTTTGAGAAGGTTATGACAGACCACAGAGTTTCTTTGGAGGAATTAAAAAAGGAAAACCAACAAATAATTAATCAAATAC
AAGAATCTCATGCTGAAATTATCCAGGAAAAAGAAAAACAGTTACAGGAATTAAAACTCAAGGTTTCTGATTTGTCAGACACGAGATGCA
AGTTAGAGGTTGAACTTGCGTTGAAGGAAGCAGAAACTGATGAAATAAAAATTTTGCTGGAAGAAAGCAGAGCCCAGCAGAAGGAGACCT
TGAAATCTCTTCTTGAACAAGAGACAGAAAATTTGAGAACAGAAATTAGTAAACTCAACCAAAAGATTCAGGATAATAATGAAAATTATC
AGGTGGGCTTAGCAGAGCTAAGAACTTTAATGACAATTGAAAAAGATCAGTGTATTTCCGAGTTAATTAGTAGACATGAAGAAGAATCTA
ATATACTTAAAGCTGAATTAAACAAAGTAACATCTTTGCATAACCAAGCATTTGAAATAGAAAAAAACCTAAAAGAACAAATAATTGAAC
TGCAGAGTAAATTGGATTCAGAATTGAGTGCTCTTGAAAGACAAAAAGATGAAAAAATTACCCAACAAGAAGAGAAATACGAAGCTATTA
TCCAGAACCTTGAGAAAGACAGACAAAAATTGGTCAGCAGCCAGGAGCAAGACAGAGAACAGTTAATTCAGAAGCTTAATTGTGAAAAAG
ATGAAGCTATTCAGACTGCCCTAAAAGAATTTAAATTGGAGAGAGAAGTTGTTGAGAAAGAGTTATTAGAAAAAGTTAAACATCTTGAGA
ATCAAATAGCAAAAAGTTAAAAGAGATGTTTCCAGGTTTTCGACTAGCACTTCCTCCAAAACGCTGGTTTAAAGATAATTACAATGCTGA
CTTTTTAGAAGACAGACAATTAGGATTACAAGCGTTTCTTCAAAATTTAGTAGCTCACAAGGACATTGCTAACTGCCTTGCAGTGAGAGA
ATTTCTTTGTTTGGATGATCCACCGGGTCCATTTGATAGCCTAGAAGAAAGCAGGGCATTCTGTGAAACTTTAGAAGAGACAAACTACCG
CTTACAGAAAGAACTACTTGAAAAACAAAAGGAGATGGAATCACTAAAGAAACTGCTCAGTGAGAAGCAACTTCATATAGACACTTTAGA
GAACAGAATCAGAACATTGTCTTTAGAACCTGAAGAATCACTGGATGTGTCAGAAACAGAAGGTGAACAGATCCTAAAGGTGGAGTCCTC
TGCACTTGAGGTTGATCAAGATGTCCTGGATGAAGAATCTAGAGCTGATAATAAACCATGCTTAAGTTTTAGTGAACCTGAAAATGCTGT
ATCAGAGATAGAAGTAGCAGAAGTGGCATATGATGCTGAAGAAGACTAATGTATCACAAGCAGTTCCCTCCATTTAGACTATTCAAAAAT
TTAGAAGAGTGGCAAATACTATTTTAAAAGAAGAACCAAGAACTGTAAAACATATAGAAAAGAGCAAGAATGCACATGTATAAAGTTTAC
ATAAAGAAGTTTTTTTAAGTTATTGAGATAGGAAATATATTCACTGCTGCTTTTAATTGTATTTTATCCAATTACATTTAATACACTAAA
AAAAATCTTGTTGGAATTCTGTTATCAAGGCCCACATTCTTAAATACTGTGCATAAATTATTATGGTGTTTTGCCTATATATTGCTCCAA
ACTACTGTGTATATATGTATGTGTGTTAAATCACCAATTATATTAATCAAATGGAAATTAATTGCATGTTACTATCTGGGTGATATATTC
TTCTTTATATCTCTGACATGACATATTTTCATTAATAGTTTAAATCAGTGACCATCATAATAAAGATAAAATTTAGTTGAGTTTTTAATG
TTTACATGTTTACATCTCTAAATAAAATTTGCTTATTTGAAATGTTAATGCTCTTTAGAAAAATGACTTTCTAGTACCAAAGGAAAACTA
CTTGAAAGAGCTGTAATCATATAGCTAAAGTGATAAGATAGCCTTGATTTTAAAAGCTGATTCATTAATATCAAAATACTTTAATAAGTG
TCACAGTTATTAATATGTTACATTTGTTTAGTTTCCACGTAATCTTTATCTCTACCTAGATTTAGTGAGTTTGCCTCTTTCAGAATACTA
CCTCCTTTTGTTAAGGCATATTCTTTCGAAAATATAGATTCTAAATAAATAGGGGCTTATACAAAAAAGAAAATAAAAAGCCATATATAC
TGCAAAGTTCCTAACTGGCTTGACTCCTGACATTGCATTTTTATTTCTATTTGTGTGAAGATGTTGTTATACTGTATTATGGCTGATTTT
CTTTTTAATATATTTAGCCAAGTGATGCACTTTATGATAATTAAACTCTTTTGTGCCAAGTTTAATTGGTGGATTTTTTTAGTAAGTAGA
GTTAGGAGAAAGAATTATGTAGTGCCTTTACTATTTCACTTTCTACAAAAGTCTCCTAGGGTCTTTGAGTCAGCTTTATGAAAAAATGTT
TGTTTATTTCAGCTTTGTGTACAGTCATTAAAAGTGCCTTGTTTCATTTTTATAGGATGAAGTTATTTATTTTCTATTTTCACTGTTTTG
CATATTGCTGTTAATAAGCATTGTAATCATGCTGGCATTTTGCAATCCCAGTCGGTATGCTTTCTAAAAACTGAGGGAAACTTACTGGGG
AAATAGAATAACAATCTCCATTTTTTTCTTTACTATCTAAAAGTTTATCGGTATCTTGATGTATATATATATTAAGGTGTGGCTGTTTAA
AATTCTAATGACATATATCAACACATTCAATGGCTGTTGTTAACCTTTGAAGTAAAAAGGAGATCACTTTTTACCAAATAACCAAAAATT
TTTAGTCTGTCAAAGTGCACAGGTATGTTCTCAGAACATTTTTCACAATGTGTATCAGAAATATGTTTGCTATCCTTAGAGACAGAAATG
AATATAATAAATTGATCTGCTTATTTATTAAAATTATTATTCTAGACTTACAAAAGGCTTAAAAAGAACAATCATTTAATCAGTACCATT
CTGTATCTTATATAACAGATCTTTGCCAAATTCTAGATATTATAGTGTTGCCTGTCTGTTCTAAAGCGAACCAGCCACTTTTTCAATCTG
GCTTTTTGGAAGATTGTATTTAAAGTTCTTCAAGGATGAAGAAAAAAATCTGTTAATTAGGTAAACCACTATTATTTATATTTATAATTT

>72553_72553_6_RB1CC1-SNX16_RB1CC1_chr8_53568568_ENST00000435644_SNX16_chr8_82736175_ENST00000396330_length(amino acids)=1274AA_BP=
MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRPPAIPKT
TFSTENDMEIKVEESLMMPAVFHTVASRTQLALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ
SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSFPKSVEHVSPDTA
DAESGKEIRESCQSTVHQQDETTIDTKDGDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK
AIKGLEDRLYALDQMIASCGRLVNEQKELAQGFLANQKRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHV
RLKWCCFVMLHADQDGEKLQALLRLVIELLERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESFGK
LFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQ
TITDLLSEQKASVSQTSPQSASSPRMESTAGITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLD
LDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHF
SIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV
CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKE
LEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEE
SRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEK
NLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL

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Fusion Gene PPI Analysis for RB1CC1-SNX16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RB1CC1-SNX16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RB1CC1-SNX16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource