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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RB1-HTR2C (FusionGDB2 ID:72563)

Fusion Gene Summary for RB1-HTR2C

check button Fusion gene summary
Fusion gene informationFusion gene name: RB1-HTR2C
Fusion gene ID: 72563
HgeneTgene
Gene symbol

RB1

HTR2C

Gene ID

5925

3358

Gene nameRB transcriptional corepressor 15-hydroxytryptamine receptor 2C
SynonymsOSRC|PPP1R130|RB|p105-Rb|p110-RB1|pRb|pp1105-HT1C|5-HT2C|5-HTR2C|5HTR2C|HTR1C
Cytomap

13q14.2

Xq23

Type of geneprotein-codingprotein-coding
Descriptionretinoblastoma-associated proteinGOS563 exon 17 substitution mutation causes premature stopexon 17 tumor GOS561 substitution mutation causes premature stopprepro-retinoblastoma-associated proteinprotein phosphatase 1, regulatory subunit 130retinoblas5-hydroxytryptamine receptor 2C5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled5-hydroxytryptamine receptor 1Cserotonin 5-HT-1C receptorserotonin 5-HT-2C receptor
Modification date2020032920200313
UniProtAcc.

P28335

Ensembl transtripts involved in fusion geneENST00000267163, ENST00000484879, 
ENST00000371950, ENST00000276198, 
ENST00000371951, 
Fusion gene scores* DoF score23 X 9 X 13=26913 X 4 X 2=24
# samples 274
** MAII scorelog2(27/2691*10)=-3.31711107858959
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RB1 [Title/Abstract] AND HTR2C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRB1(48881542)-HTR2C(114141152), # samples:3
Anticipated loss of major functional domain due to fusion event.RB1-HTR2C seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RB1-HTR2C seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
RB1-HTR2C seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
RB1-HTR2C seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRB1

GO:0043550

regulation of lipid kinase activity

16286473

HgeneRB1

GO:0045892

negative regulation of transcription, DNA-templated

10783144|12065415|19223331

HgeneRB1

GO:2000679

positive regulation of transcription regulatory region DNA binding

25100735

TgeneHTR2C

GO:0006874

cellular calcium ion homeostasis

19057895

TgeneHTR2C

GO:0007200

phospholipase C-activating G protein-coupled receptor signaling pathway

12970106

TgeneHTR2C

GO:0010513

positive regulation of phosphatidylinositol biosynthetic process

19057895

TgeneHTR2C

GO:0019934

cGMP-mediated signaling

12970106

TgeneHTR2C

GO:0042493

response to drug

18703043

TgeneHTR2C

GO:0070374

positive regulation of ERK1 and ERK2 cascade

19057895


check buttonFusion gene breakpoints across RB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HTR2C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-D6-6827-01ARB1chr13

48881542

-HTR2CchrX

114141152

+
ChimerDB4HNSCTCGA-D6-6827-01ARB1chr13

48881542

+HTR2CchrX

114141152

+
ChimerDB4HNSCTCGA-D6-6827RB1chr13

48881542

+HTR2CchrX

114141151

+
ChimerDB4HNSCTCGA-D6-6827RB1chr13

48881542

+HTR2CchrX

114141152

+


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Fusion Gene ORF analysis for RB1-HTR2C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000267163ENST00000371950RB1chr13

48881542

+HTR2CchrX

114141152

+
Frame-shiftENST00000267163ENST00000371950RB1chr13

48881542

+HTR2CchrX

114141151

+
In-frameENST00000267163ENST00000276198RB1chr13

48881542

+HTR2CchrX

114141152

+
In-frameENST00000267163ENST00000276198RB1chr13

48881542

+HTR2CchrX

114141151

+
In-frameENST00000267163ENST00000371951RB1chr13

48881542

+HTR2CchrX

114141152

+
In-frameENST00000267163ENST00000371951RB1chr13

48881542

+HTR2CchrX

114141151

+
intron-3CDSENST00000484879ENST00000276198RB1chr13

48881542

+HTR2CchrX

114141152

+
intron-3CDSENST00000484879ENST00000276198RB1chr13

48881542

+HTR2CchrX

114141151

+
intron-3CDSENST00000484879ENST00000371950RB1chr13

48881542

+HTR2CchrX

114141152

+
intron-3CDSENST00000484879ENST00000371950RB1chr13

48881542

+HTR2CchrX

114141151

+
intron-3CDSENST00000484879ENST00000371951RB1chr13

48881542

+HTR2CchrX

114141152

+
intron-3CDSENST00000484879ENST00000371951RB1chr13

48881542

+HTR2CchrX

114141151

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000267163RB1chr1348881542+ENST00000371951HTR2CchrX114141152+23214023171228303
ENST00000267163RB1chr1348881542+ENST00000276198HTR2CchrX114141152+38754023171228303
ENST00000267163RB1chr1348881542+ENST00000371951HTR2CchrX114141151+23214023171228303
ENST00000267163RB1chr1348881542+ENST00000276198HTR2CchrX114141151+38754023171228303

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000267163ENST00000371951RB1chr1348881542+HTR2CchrX114141152+0.0005446550.9994554
ENST00000267163ENST00000276198RB1chr1348881542+HTR2CchrX114141152+0.0003281170.99967194
ENST00000267163ENST00000371951RB1chr1348881542+HTR2CchrX114141151+0.0005446550.9994554
ENST00000267163ENST00000276198RB1chr1348881542+HTR2CchrX114141151+0.0003281170.99967194

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Fusion Genomic Features for RB1-HTR2C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RB1chr1348881542+HTR2CchrX114141151+1.64E-070.9999999
RB1chr1348881542+HTR2CchrX114141151+1.64E-070.9999999
RB1chr1348881542+HTR2CchrX114141151+1.64E-070.9999999
RB1chr1348881542+HTR2CchrX114141151+1.64E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for RB1-HTR2C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:48881542/chrX:114141152)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HTR2C

P28335

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis. {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+22710_1888929.0Compositional biasNote=Poly-Ala
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+22720_2988929.0Compositional biasNote=Poly-Pro
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+22710_1888929.0Compositional biasNote=Poly-Ala
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+22720_2988929.0Compositional biasNote=Poly-Pro
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846364_368183459.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846456_458183459.0MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046151_153151249.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046364_368151249.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046456_458151249.0MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157364_368183459.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157456_458183459.0MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846364_368183459.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846456_458183459.0MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046151_153151249.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046364_368151249.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046456_458151249.0MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157364_368183459.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157456_458183459.0MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846324_328183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046324_328151249.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157324_328183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846324_328183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046324_328151249.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157324_328183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846194_213183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846236_311183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846334_348183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846372_458183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046151_170151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046194_213151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046236_311151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046334_348151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046372_458151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157194_213183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157236_311183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157334_348183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157372_458183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846194_213183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846236_311183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846334_348183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846372_458183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046151_170151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046194_213151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046236_311151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046334_348151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046372_458151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157194_213183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157236_311183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157334_348183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157372_458183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846214_235183459.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846312_333183459.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846349_371183459.0TransmembraneHelical%3B Name%3D7
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046171_193151249.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046214_235151249.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046312_333151249.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046349_371151249.0TransmembraneHelical%3B Name%3D7
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157214_235183459.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157312_333183459.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157349_371183459.0TransmembraneHelical%3B Name%3D7
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846214_235183459.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846312_333183459.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846349_371183459.0TransmembraneHelical%3B Name%3D7
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046171_193151249.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046214_235151249.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046312_333151249.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046349_371151249.0TransmembraneHelical%3B Name%3D7
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157214_235183459.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157312_333183459.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157349_371183459.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+227860_87688929.0MotifBipartite nuclear localization signal
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227860_87688929.0MotifBipartite nuclear localization signal
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+227373_57988929.0RegionNote=Domain A
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+227373_77188929.0RegionNote=Pocket%3B binds T and E1A
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+227580_63988929.0RegionNote=Spacer
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+227640_77188929.0RegionNote=Domain B
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227373_57988929.0RegionNote=Domain A
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227373_77188929.0RegionNote=Pocket%3B binds T and E1A
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227580_63988929.0RegionNote=Spacer
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227640_77188929.0RegionNote=Domain B
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846151_153183459.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157151_153183459.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846151_153183459.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157151_153183459.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846134_139183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046134_139151249.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157134_139183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846134_139183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046134_139151249.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157134_139183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846111_127183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846151_170183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST000002761984633_52183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST000002761984679_89183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046111_127151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719504633_52151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719504679_89151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157111_127183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157151_170183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719515733_52183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719515779_89183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846111_127183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846151_170183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST000002761984633_52183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST000002761984679_89183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046111_127151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719504633_52151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719504679_89151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157111_127183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157151_170183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719515733_52183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719515779_89183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846128_150183459.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846171_193183459.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141151ENST000002761984653_78183459.0TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141151ENST000002761984690_110183459.0TransmembraneHelical%3B Name%3D2
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046128_150151249.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719504653_78151249.0TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719504690_110151249.0TransmembraneHelical%3B Name%3D2
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157128_150183459.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157171_193183459.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719515753_78183459.0TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719515790_110183459.0TransmembraneHelical%3B Name%3D2
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846128_150183459.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846171_193183459.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141152ENST000002761984653_78183459.0TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141152ENST000002761984690_110183459.0TransmembraneHelical%3B Name%3D2
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046128_150151249.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719504653_78151249.0TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719504690_110151249.0TransmembraneHelical%3B Name%3D2
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157128_150183459.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157171_193183459.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719515753_78183459.0TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719515790_110183459.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for RB1-HTR2C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72563_72563_1_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141151_ENST00000276198_length(transcript)=3875nt_BP=402nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGTGTATCAGTTCCTATCCCTGTGATTGGACTGAGGGACGAAGAAAAGG
TGTTCGTGAACAACACGACGTGCGTGCTCAACGACCCAAATTTCGTTCTTATTGGGTCCTTCGTAGCTTTCTTCATACCGCTGACGATTA
TGGTGATTACGTATTGCCTGACCATCTACGTTCTGCGCCGACAAGCTTTGATGTTACTGCACGGCCACACCGAGGAACCGCCTGGACTAA
GTCTGGATTTCCTGAAGTGCTGCAAGAGGAATACGGCCGAGGAAGAGAACTCTGCAAACCCTAACCAAGACCAGAACGCACGCCGAAGAA
AGAAGAAGGAGAGACGTCCTAGGGGCACCATGCAGGCTATCAACAATGAAAGAAAAGCTTCGAAAGTCCTTGGGATTGTTTTCTTTGTGT
TTCTGATCATGTGGTGCCCATTTTTCATTACCAATATTCTGTCTGTTCTTTGTGAGAAGTCCTGTAACCAAAAGCTCATGGAAAAGCTTC
TGAATGTGTTTGTTTGGATTGGCTATGTTTGTTCAGGAATCAATCCTCTGGTGTATACTCTGTTCAACAAAATTTACCGAAGGGCATTCT
CCAACTATTTGCGTTGCAATTATAAGGTAGAGAAAAAGCCTCCTGTCAGGCAGATTCCAAGAGTTGCCGCCACTGCTTTGTCTGGGAGGG
AGCTTAATGTTAACATTTATCGGCATACCAATGAACCGGTGATCGAGAAAGCCAGTGACAATGAGCCCGGTATAGAGATGCAAGTTGAGA
ATTTAGAGTTACCAGTAAATCCCTCCAGTGTGGTTAGCGAAAGGATTAGCAGTGTGTGAGAAAGAACAGCACAGTCTTTTCCTACGGTAC
AAGCTACATATGTAGGAAAATTTTCTTCTTTAATTTTTCTGTTGGTCTTAACTAATGTAAATATTGCTGTCTGAAAAAGTGTTTTTACAT
ATAGCTTTGCAACCTTGTACTTTACAATCATGCCTACATTAGTGAGATTTAGGGTTCTATATTTACTGTTTATAATAGGTGGAGACTAAC
TTATTTTGATTGTTTGATGAATAAAATGTTTATTTTTGCTCTCCCTCCCTTCTTTCCTTCCTTTTTTCCTTTCTTCCTTCCTTTCTCTCT
TTCTTTTGTGCATATGGCAACGTTCATGTTCATCTCAGGTGGCATTTGCAGGTGACCAGAATGAGGCACATGACAGTGGTTATATTTCAA
CCACACCTAAATTAACAAATTCAGTGGACATTTGTTCTGGGTTAACAGTAAATATACACTTTACATTCTTGCTCTGCTCATCTACACATA
TAAACACAGTAAGATAGGTTCTGCTTTCTGATACATCTGTCAGTGAGTCAGAGGCAGAACCTAGTCTTGTTGTTCATATAGGGGCAAAAA
TTTGACATTGTCAGAATGTTGTGTTGGTATTTACTGCAATGTCTGTCCCTAAACATAGTGGTATTTTAACATAGCAGCTGGTTAACCGGG
ACTACAGAAGTGGAAGGATAATGAGATGTAATACACCAAATAGCTTTTCACTTCTTAAGGACAGTGTTCAAATTCTGATTATTACAACAA
GCAAACTGAAATTAGTGTTTTCATTCTGGTCCTTAGTAAATTCCTAATTCTATGATTAAACTGGGAAATGAGATCCCAGAGTTATTTCCC
AACCCAGGATTCAACATCAATTGGGTTTTGATCTCAGCATCCTGGAAATTTGTGTGCTTCACACAAAGTGAAATTAGTATTTTGAGCCTT
ATTAAAATATTTTCTTAATTATGGTACCTCTGTCTATAGGACTTAATTTAGCAGTCCATTTTTGAGTAAAACTTGTATTGGAAGTATAGA
TGGTAGAAACTTTGGAAGTTTTACTTGATTAAGGACTACAGAATTGGGCCCTTAGAATGTGAAAAAAAAAAGTAATTAAAAAGACACTTT
TACCGAACTCGGGATTACAGAAACACGGAGTTTCCATTTGGATTTTAAACAAAATTTATGTCATTTTCAGATCCTTCCAAACTCTCTAGT
GCAGGAAAAGGCTGCAGCTAATTTGTGAAAGTGGCAAGCTCTTCATTGCACTGCAGTTATTTACCAGAAGTTTAAATCTTTGTTAAAATA
TAGTGTTGTGTTACAATAAGTGTTGGCCATCATTTCATTCGTGGGCCTGCTGCTCTCTAAGAATTCAGTAGCATTTTAATAGTTTCTAAA
CCATGAAAAGTTTTCAAGCATTGCTAAAGTCAGGCCATTCAGTCTATGCTGTGTGCAGAGTATACAAGTGTTTCTAGTAACAGTATTTCC
ATACGTGCCCATTTCACACAACTGTGGATAAATTTTGGAAGAATTCATGATGCTAGTTCTTACGCTTGACAGTTACTTACACACCTGAGA
ATGTGCCTCTCAGTATCTTAAAATTGGTTAATGAAAAATCTGAATTTCTAAAACCCTTGGTCTGTGTTCTCAACACACAGTATAGATAAA
TCCAATAGTCTGCCACAAGGGCAGTGGAAGAGCTGCTGTATTTGAGGAAACTCATACAGTCTCTATTTGATTTGCAACACTGCCAAACAT
CAGTCAATTGCTTGAGCATGCCCAAATATAACATGAAAGTCAAGTCTACCTGCCTTGCCTGTTAGGTCTGTTGAAGTGCATGTTAAAATA
ATTATATGAAGCAGAATGAGATGATTTAATTCTTACCGAAATGAAAATGGCTGAAGAAACACAGCATGCATTTAGCATGAGTTCTGCACA
TACAGATGGTGTCCTGCATGTATGCCATGTATGTTGCATGAATCCATCGATTTGTATTAATGTAGGGCAGAATAGCTGATAGAAGAAGGA
CTGAAGAAAATCCTTCAGCAATCCTTAAAAAGACCATGCATTCAGATCTGAAGTAGTGTGAGTGTTAGAAAAAACTGGAAACATCTGATT
TCTGAACTATCAGGGCAAGCTCATAGCACATGTTTTACAAAGAAACAAAATATAAATCACAGATTTCCAAAAGTACTAGCAATAAGTTGA
ATGATAATAGCTCACAGCACATTTGTTAATGATTCTTGTGTCATCAAGTAGTAGTACTTAATAGTACCCAACCTGGTAATTATCCTCAAG
TTGTGTGCTATTCGTAAGTTCTGTGCAGTTTGGTATGAAACAAATATACTCATTTGGATATAAATCTTACCCTTCAATGTTAAATCTACA
AACTTTTATAAATGTTTTAAAGAAGTCCATGTGATAATTGTAAAGGTGATGAATTTACCATCAAACAAATCATTTTGATGTATTATTATA
TATGTATATCTGTGTAAGACACGTGCAACAGACTGCCTTATATTATTTTCTGTAATTCTTCTCCTTTGTCAAATGGTATTTTTTGTGAAT
GGTTGCAAAGTGTTGTCTTATTCCTAATTCCTGTATGTTATCCACTACAGGTTTTATGAGACTTCCTATTAATTTATTAAATTTATTAAA

>72563_72563_1_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141151_ENST00000276198_length(amino acids)=303AA_BP=28
MSEIKDTRSCQRESLVNLGESFICGWSIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQA
LMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSV
LCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIE

--------------------------------------------------------------
>72563_72563_2_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141151_ENST00000371951_length(transcript)=2321nt_BP=402nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGTGTATCAGTTCCTATCCCTGTGATTGGACTGAGGGACGAAGAAAAGG
TGTTCGTGAACAACACGACGTGCGTGCTCAACGACCCAAATTTCGTTCTTATTGGGTCCTTCGTAGCTTTCTTCATACCGCTGACGATTA
TGGTGATTACGTATTGCCTGACCATCTACGTTCTGCGCCGACAAGCTTTGATGTTACTGCACGGCCACACCGAGGAACCGCCTGGACTAA
GTCTGGATTTCCTGAAGTGCTGCAAGAGGAATACGGCCGAGGAAGAGAACTCTGCAAACCCTAACCAAGACCAGAACGCACGCCGAAGAA
AGAAGAAGGAGAGACGTCCTAGGGGCACCATGCAGGCTATCAACAATGAAAGAAAAGCTTCGAAAGTCCTTGGGATTGTTTTCTTTGTGT
TTCTGATCATGTGGTGCCCATTTTTCATTACCAATATTCTGTCTGTTCTTTGTGAGAAGTCCTGTAACCAAAAGCTCATGGAAAAGCTTC
TGAATGTGTTTGTTTGGATTGGCTATGTTTGTTCAGGAATCAATCCTCTGGTGTATACTCTGTTCAACAAAATTTACCGAAGGGCATTCT
CCAACTATTTGCGTTGCAATTATAAGGTAGAGAAAAAGCCTCCTGTCAGGCAGATTCCAAGAGTTGCCGCCACTGCTTTGTCTGGGAGGG
AGCTTAATGTTAACATTTATCGGCATACCAATGAACCGGTGATCGAGAAAGCCAGTGACAATGAGCCCGGTATAGAGATGCAAGTTGAGA
ATTTAGAGTTACCAGTAAATCCCTCCAGTGTGGTTAGCGAAAGGATTAGCAGTGTGTGAGAAAGAACAGCACAGTCTTTTCCTACGGTAC
AAGCTACATATGTAGGAAAATTTTCTTCTTTAATTTTTCTGTTGGTCTTAACTAATGTAAATATTGCTGTCTGAAAAAGTGTTTTTACAT
ATAGCTTTGCAACCTTGTACTTTACAATCATGCCTACATTAGTGAGATTTAGGGTTCTATATTTACTGTTTATAATAGGTGGAGACTAAC
TTATTTTGATTGTTTGATGAATAAAATGTTTATTTTTGCTCTCCCTCCCTTCTTTCCTTCCTTTTTTCCTTTCTTCCTTCCTTTCTCTCT
TTCTTTTGTGCATATGGCAACGTTCATGTTCATCTCAGGTGGCATTTGCAGGTGACCAGAATGAGGCACATGACAGTGGTTATATTTCAA
CCACACCTAAATTAACAAATTCAGTGGACATTTGTTCTGGGTTAACAGTAAATATACACTTTACATTCTTGCTCTGCTCATCTACACATA
TAAACACAGTAAGATAGGTTCTGCTTTCTGATACATCTGTCAGTGAGTCAGAGGCAGAACCTAGTCTTGTTGTTCATATAGGGGCAAAAA
TTTGACATTGTCAGAATGTTGTGTTGGTATTTACTGCAATGTCTGTCCCTAAACATAGTGGTATTTTAACATAGCAGCTGGTTAACCGGG
ACTACAGAAGTGGAAGGATAATGAGATGTAATACACCAAATAGCTTTTCACTTCTTAAGGACAGTGTTCAAATTCTGATTATTACAACAA
GCAAACTGAAATTAGTGTTTTCATTCTGGTCCTTAGTAAATTCCTAATTCTATGATTAAACTGGGAAATGAGATCCCAGAGTTATTTCCC
AACCCAGGATTCAACATCAATTGGGTTTTGATCTCAGCATCCTGGAAATTTGTGTGCTTCACACAAAGTGAAATTAGTATTTTGAGCCTT
ATTAAAATATTTTCTTAATTATGGTACCTCTGTCTATAGGACTTAATTTAGCAGTCCATTTTTGAGTAAAACTTGTATTGGAAGTATAGA

>72563_72563_2_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141151_ENST00000371951_length(amino acids)=303AA_BP=28
MSEIKDTRSCQRESLVNLGESFICGWSIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQA
LMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSV
LCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIE

--------------------------------------------------------------
>72563_72563_3_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141152_ENST00000276198_length(transcript)=3875nt_BP=402nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGTGTATCAGTTCCTATCCCTGTGATTGGACTGAGGGACGAAGAAAAGG
TGTTCGTGAACAACACGACGTGCGTGCTCAACGACCCAAATTTCGTTCTTATTGGGTCCTTCGTAGCTTTCTTCATACCGCTGACGATTA
TGGTGATTACGTATTGCCTGACCATCTACGTTCTGCGCCGACAAGCTTTGATGTTACTGCACGGCCACACCGAGGAACCGCCTGGACTAA
GTCTGGATTTCCTGAAGTGCTGCAAGAGGAATACGGCCGAGGAAGAGAACTCTGCAAACCCTAACCAAGACCAGAACGCACGCCGAAGAA
AGAAGAAGGAGAGACGTCCTAGGGGCACCATGCAGGCTATCAACAATGAAAGAAAAGCTTCGAAAGTCCTTGGGATTGTTTTCTTTGTGT
TTCTGATCATGTGGTGCCCATTTTTCATTACCAATATTCTGTCTGTTCTTTGTGAGAAGTCCTGTAACCAAAAGCTCATGGAAAAGCTTC
TGAATGTGTTTGTTTGGATTGGCTATGTTTGTTCAGGAATCAATCCTCTGGTGTATACTCTGTTCAACAAAATTTACCGAAGGGCATTCT
CCAACTATTTGCGTTGCAATTATAAGGTAGAGAAAAAGCCTCCTGTCAGGCAGATTCCAAGAGTTGCCGCCACTGCTTTGTCTGGGAGGG
AGCTTAATGTTAACATTTATCGGCATACCAATGAACCGGTGATCGAGAAAGCCAGTGACAATGAGCCCGGTATAGAGATGCAAGTTGAGA
ATTTAGAGTTACCAGTAAATCCCTCCAGTGTGGTTAGCGAAAGGATTAGCAGTGTGTGAGAAAGAACAGCACAGTCTTTTCCTACGGTAC
AAGCTACATATGTAGGAAAATTTTCTTCTTTAATTTTTCTGTTGGTCTTAACTAATGTAAATATTGCTGTCTGAAAAAGTGTTTTTACAT
ATAGCTTTGCAACCTTGTACTTTACAATCATGCCTACATTAGTGAGATTTAGGGTTCTATATTTACTGTTTATAATAGGTGGAGACTAAC
TTATTTTGATTGTTTGATGAATAAAATGTTTATTTTTGCTCTCCCTCCCTTCTTTCCTTCCTTTTTTCCTTTCTTCCTTCCTTTCTCTCT
TTCTTTTGTGCATATGGCAACGTTCATGTTCATCTCAGGTGGCATTTGCAGGTGACCAGAATGAGGCACATGACAGTGGTTATATTTCAA
CCACACCTAAATTAACAAATTCAGTGGACATTTGTTCTGGGTTAACAGTAAATATACACTTTACATTCTTGCTCTGCTCATCTACACATA
TAAACACAGTAAGATAGGTTCTGCTTTCTGATACATCTGTCAGTGAGTCAGAGGCAGAACCTAGTCTTGTTGTTCATATAGGGGCAAAAA
TTTGACATTGTCAGAATGTTGTGTTGGTATTTACTGCAATGTCTGTCCCTAAACATAGTGGTATTTTAACATAGCAGCTGGTTAACCGGG
ACTACAGAAGTGGAAGGATAATGAGATGTAATACACCAAATAGCTTTTCACTTCTTAAGGACAGTGTTCAAATTCTGATTATTACAACAA
GCAAACTGAAATTAGTGTTTTCATTCTGGTCCTTAGTAAATTCCTAATTCTATGATTAAACTGGGAAATGAGATCCCAGAGTTATTTCCC
AACCCAGGATTCAACATCAATTGGGTTTTGATCTCAGCATCCTGGAAATTTGTGTGCTTCACACAAAGTGAAATTAGTATTTTGAGCCTT
ATTAAAATATTTTCTTAATTATGGTACCTCTGTCTATAGGACTTAATTTAGCAGTCCATTTTTGAGTAAAACTTGTATTGGAAGTATAGA
TGGTAGAAACTTTGGAAGTTTTACTTGATTAAGGACTACAGAATTGGGCCCTTAGAATGTGAAAAAAAAAAGTAATTAAAAAGACACTTT
TACCGAACTCGGGATTACAGAAACACGGAGTTTCCATTTGGATTTTAAACAAAATTTATGTCATTTTCAGATCCTTCCAAACTCTCTAGT
GCAGGAAAAGGCTGCAGCTAATTTGTGAAAGTGGCAAGCTCTTCATTGCACTGCAGTTATTTACCAGAAGTTTAAATCTTTGTTAAAATA
TAGTGTTGTGTTACAATAAGTGTTGGCCATCATTTCATTCGTGGGCCTGCTGCTCTCTAAGAATTCAGTAGCATTTTAATAGTTTCTAAA
CCATGAAAAGTTTTCAAGCATTGCTAAAGTCAGGCCATTCAGTCTATGCTGTGTGCAGAGTATACAAGTGTTTCTAGTAACAGTATTTCC
ATACGTGCCCATTTCACACAACTGTGGATAAATTTTGGAAGAATTCATGATGCTAGTTCTTACGCTTGACAGTTACTTACACACCTGAGA
ATGTGCCTCTCAGTATCTTAAAATTGGTTAATGAAAAATCTGAATTTCTAAAACCCTTGGTCTGTGTTCTCAACACACAGTATAGATAAA
TCCAATAGTCTGCCACAAGGGCAGTGGAAGAGCTGCTGTATTTGAGGAAACTCATACAGTCTCTATTTGATTTGCAACACTGCCAAACAT
CAGTCAATTGCTTGAGCATGCCCAAATATAACATGAAAGTCAAGTCTACCTGCCTTGCCTGTTAGGTCTGTTGAAGTGCATGTTAAAATA
ATTATATGAAGCAGAATGAGATGATTTAATTCTTACCGAAATGAAAATGGCTGAAGAAACACAGCATGCATTTAGCATGAGTTCTGCACA
TACAGATGGTGTCCTGCATGTATGCCATGTATGTTGCATGAATCCATCGATTTGTATTAATGTAGGGCAGAATAGCTGATAGAAGAAGGA
CTGAAGAAAATCCTTCAGCAATCCTTAAAAAGACCATGCATTCAGATCTGAAGTAGTGTGAGTGTTAGAAAAAACTGGAAACATCTGATT
TCTGAACTATCAGGGCAAGCTCATAGCACATGTTTTACAAAGAAACAAAATATAAATCACAGATTTCCAAAAGTACTAGCAATAAGTTGA
ATGATAATAGCTCACAGCACATTTGTTAATGATTCTTGTGTCATCAAGTAGTAGTACTTAATAGTACCCAACCTGGTAATTATCCTCAAG
TTGTGTGCTATTCGTAAGTTCTGTGCAGTTTGGTATGAAACAAATATACTCATTTGGATATAAATCTTACCCTTCAATGTTAAATCTACA
AACTTTTATAAATGTTTTAAAGAAGTCCATGTGATAATTGTAAAGGTGATGAATTTACCATCAAACAAATCATTTTGATGTATTATTATA
TATGTATATCTGTGTAAGACACGTGCAACAGACTGCCTTATATTATTTTCTGTAATTCTTCTCCTTTGTCAAATGGTATTTTTTGTGAAT
GGTTGCAAAGTGTTGTCTTATTCCTAATTCCTGTATGTTATCCACTACAGGTTTTATGAGACTTCCTATTAATTTATTAAATTTATTAAA

>72563_72563_3_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141152_ENST00000276198_length(amino acids)=303AA_BP=28
MSEIKDTRSCQRESLVNLGESFICGWSIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQA
LMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSV
LCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIE

--------------------------------------------------------------
>72563_72563_4_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141152_ENST00000371951_length(transcript)=2321nt_BP=402nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGTGTATCAGTTCCTATCCCTGTGATTGGACTGAGGGACGAAGAAAAGG
TGTTCGTGAACAACACGACGTGCGTGCTCAACGACCCAAATTTCGTTCTTATTGGGTCCTTCGTAGCTTTCTTCATACCGCTGACGATTA
TGGTGATTACGTATTGCCTGACCATCTACGTTCTGCGCCGACAAGCTTTGATGTTACTGCACGGCCACACCGAGGAACCGCCTGGACTAA
GTCTGGATTTCCTGAAGTGCTGCAAGAGGAATACGGCCGAGGAAGAGAACTCTGCAAACCCTAACCAAGACCAGAACGCACGCCGAAGAA
AGAAGAAGGAGAGACGTCCTAGGGGCACCATGCAGGCTATCAACAATGAAAGAAAAGCTTCGAAAGTCCTTGGGATTGTTTTCTTTGTGT
TTCTGATCATGTGGTGCCCATTTTTCATTACCAATATTCTGTCTGTTCTTTGTGAGAAGTCCTGTAACCAAAAGCTCATGGAAAAGCTTC
TGAATGTGTTTGTTTGGATTGGCTATGTTTGTTCAGGAATCAATCCTCTGGTGTATACTCTGTTCAACAAAATTTACCGAAGGGCATTCT
CCAACTATTTGCGTTGCAATTATAAGGTAGAGAAAAAGCCTCCTGTCAGGCAGATTCCAAGAGTTGCCGCCACTGCTTTGTCTGGGAGGG
AGCTTAATGTTAACATTTATCGGCATACCAATGAACCGGTGATCGAGAAAGCCAGTGACAATGAGCCCGGTATAGAGATGCAAGTTGAGA
ATTTAGAGTTACCAGTAAATCCCTCCAGTGTGGTTAGCGAAAGGATTAGCAGTGTGTGAGAAAGAACAGCACAGTCTTTTCCTACGGTAC
AAGCTACATATGTAGGAAAATTTTCTTCTTTAATTTTTCTGTTGGTCTTAACTAATGTAAATATTGCTGTCTGAAAAAGTGTTTTTACAT
ATAGCTTTGCAACCTTGTACTTTACAATCATGCCTACATTAGTGAGATTTAGGGTTCTATATTTACTGTTTATAATAGGTGGAGACTAAC
TTATTTTGATTGTTTGATGAATAAAATGTTTATTTTTGCTCTCCCTCCCTTCTTTCCTTCCTTTTTTCCTTTCTTCCTTCCTTTCTCTCT
TTCTTTTGTGCATATGGCAACGTTCATGTTCATCTCAGGTGGCATTTGCAGGTGACCAGAATGAGGCACATGACAGTGGTTATATTTCAA
CCACACCTAAATTAACAAATTCAGTGGACATTTGTTCTGGGTTAACAGTAAATATACACTTTACATTCTTGCTCTGCTCATCTACACATA
TAAACACAGTAAGATAGGTTCTGCTTTCTGATACATCTGTCAGTGAGTCAGAGGCAGAACCTAGTCTTGTTGTTCATATAGGGGCAAAAA
TTTGACATTGTCAGAATGTTGTGTTGGTATTTACTGCAATGTCTGTCCCTAAACATAGTGGTATTTTAACATAGCAGCTGGTTAACCGGG
ACTACAGAAGTGGAAGGATAATGAGATGTAATACACCAAATAGCTTTTCACTTCTTAAGGACAGTGTTCAAATTCTGATTATTACAACAA
GCAAACTGAAATTAGTGTTTTCATTCTGGTCCTTAGTAAATTCCTAATTCTATGATTAAACTGGGAAATGAGATCCCAGAGTTATTTCCC
AACCCAGGATTCAACATCAATTGGGTTTTGATCTCAGCATCCTGGAAATTTGTGTGCTTCACACAAAGTGAAATTAGTATTTTGAGCCTT
ATTAAAATATTTTCTTAATTATGGTACCTCTGTCTATAGGACTTAATTTAGCAGTCCATTTTTGAGTAAAACTTGTATTGGAAGTATAGA

>72563_72563_4_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141152_ENST00000371951_length(amino acids)=303AA_BP=28
MSEIKDTRSCQRESLVNLGESFICGWSIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQA
LMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSV
LCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIE

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Fusion Gene PPI Analysis for RB1-HTR2C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+227763_92888.0929.0LIMD1
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227763_92888.0929.0LIMD1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RB1-HTR2C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RB1-HTR2C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource