Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ASS1-NCS1 (FusionGDB2 ID:7258)

Fusion Gene Summary for ASS1-NCS1

Fusion gene summary

Fusion gene information	Fusion gene name: ASS1-NCS1
	Fusion gene ID: 7258
		Hgene	Tgene
	Gene symbol	ASS1	NCS1
	Gene ID	445	23413
	Gene name	argininosuccinate synthase 1	neuronal calcium sensor 1
	Synonyms	ASS\|CTLN1	FLUP\|FREQ
	Cytomap	9q34.11	9q34.11
	Type of gene	protein-coding	protein-coding
	Description	argininosuccinate synthaseargininosuccinate synthetase 1citrulline-aspartate ligaseepididymis secretory sperm binding protein	neuronal calcium sensor 1frequenin homologfrequenin-like proteinfrequenin-like ubiquitous protein
	Modification date	20200313	20200313
	UniProtAcc	P00966	P62166
	Ensembl transtripts involved in fusion gene	ENST00000493984, ENST00000352480, ENST00000372393, ENST00000372394,	ENST00000372398, ENST00000458469, ENST00000493042,
Fusion gene scores	* DoF score	3 X 5 X 4=60	6 X 6 X 4=144
	# samples	4	6
	** MAII score	log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ASS1 [Title/Abstract] AND NCS1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ASS1(133355836)-NCS1(132963237), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ASS1	GO:0007623	circadian rhythm	28985504

Fusion gene breakpoints across ASS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NCS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A8-A0A4-01A	ASS1	chr9	133355836	-	NCS1	chr9	132963237	+
ChimerDB4	BRCA	TCGA-A8-A0A4-01A	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+

Top

Fusion Gene ORF analysis for ASS1-NCS1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000493984	ENST00000372398	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+
3UTR-3UTR	ENST00000493984	ENST00000458469	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+
3UTR-3UTR	ENST00000493984	ENST00000493042	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+
5CDS-3UTR	ENST00000352480	ENST00000458469	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+
5CDS-3UTR	ENST00000352480	ENST00000493042	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+
5CDS-3UTR	ENST00000372393	ENST00000458469	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+
5CDS-3UTR	ENST00000372393	ENST00000493042	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+
5CDS-3UTR	ENST00000372394	ENST00000458469	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+
5CDS-3UTR	ENST00000372394	ENST00000493042	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+
In-frame	ENST00000352480	ENST00000372398	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+
In-frame	ENST00000372393	ENST00000372398	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+
In-frame	ENST00000372394	ENST00000372398	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000352480

ASS1

chr9

133355836

ENST00000372398

NCS1

chr9

132963237

5751

910

1418

469

ENST00000372394

ASS1

chr9

133355836

ENST00000372398

NCS1

chr9

132963237

6160

1319

253

1827

524

ENST00000372393

ASS1

chr9

133355836

ENST00000372398

NCS1

chr9

132963237

5754

913

1421

448

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000352480	ENST00000372398	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+	0.001862837	0.9981371
ENST00000372394	ENST00000372398	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+	0.003394084	0.9966059
ENST00000372393	ENST00000372398	ASS1	chr9	133355836	+	NCS1	chr9	132963237	+	0.001768141	0.9982318

Top

Fusion Genomic Features for ASS1-NCS1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ASS1	chr9	133355836	+	NCS1	chr9	132963236	+	0.51100713	0.48899284
ASS1	chr9	133355836	+	NCS1	chr9	132963236	+	0.51100713	0.48899284

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ASS1-NCS1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:133355836/chr9:132963237)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ASS1 P00966	NCS1 P62166
FUNCTION: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. {ECO:0000305\|PubMed:18473344, ECO:0000305\|PubMed:27287393, ECO:0000305\|PubMed:8792870}.	FUNCTION: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ASS1

chr9:133355836

chr9:132963237

ENST00000352480

10_18

279

413.0

Nucleotide binding

ATP

Hgene

ASS1

chr9:133355836

chr9:132963237

ENST00000352480

115_123

279

413.0

Nucleotide binding

ATP

Hgene

ASS1

chr9:133355836

chr9:132963237

ENST00000372393

10_18

279

413.0

Nucleotide binding

ATP

Hgene

ASS1

chr9:133355836

chr9:132963237

ENST00000372393

115_123

279

413.0

Nucleotide binding

ATP

Hgene

ASS1

chr9:133355836

chr9:132963237

ENST00000372394

10_18

279

413.0

Nucleotide binding

ATP

Hgene

ASS1

chr9:133355836

chr9:132963237

ENST00000372394

115_123

279

413.0

Nucleotide binding

ATP

Tgene

NCS1

chr9:133355836

chr9:132963237

ENST00000372398

109_120

1579.3333333333333

Calcium binding

Tgene

NCS1

chr9:133355836

chr9:132963237

ENST00000372398

157_168

1579.3333333333333

Calcium binding

Tgene

NCS1

chr9:133355836

chr9:132963237

ENST00000372398

73_84

1579.3333333333333

Calcium binding

Tgene

NCS1

chr9:133355836

chr9:132963237

ENST00000458469

109_120

1605.0

Calcium binding

Tgene

NCS1

chr9:133355836

chr9:132963237

ENST00000458469

157_168

1605.0

Calcium binding

Tgene

NCS1

chr9:133355836

chr9:132963237

ENST00000458469

73_84

1605.0

Calcium binding

Tgene

NCS1

chr9:133355836

chr9:132963237

ENST00000372398

144_179

1579.3333333333333

Domain

EF-hand 4

Tgene

NCS1

chr9:133355836

chr9:132963237

ENST00000372398

24_59

1579.3333333333333

Domain

EF-hand 1

Tgene

NCS1

chr9:133355836

chr9:132963237

ENST00000372398

60_95

1579.3333333333333

Domain

EF-hand 2

Tgene

NCS1

chr9:133355836

chr9:132963237

ENST00000372398

96_131

1579.3333333333333

Domain

EF-hand 3

Tgene

NCS1

chr9:133355836

chr9:132963237

ENST00000458469

144_179

1605.0

Domain

EF-hand 4

Tgene

NCS1

chr9:133355836

chr9:132963237

ENST00000458469

24_59

1605.0

Domain

EF-hand 1

Tgene

NCS1

chr9:133355836

chr9:132963237

ENST00000458469

60_95

1605.0

Domain

EF-hand 2

Tgene

NCS1

chr9:133355836

chr9:132963237

ENST00000458469

96_131

1605.0

Domain

EF-hand 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for ASS1-NCS1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>7258_7258_1_ASS1-NCS1_ASS1_chr9_133355836_ENST00000352480_NCS1_chr9_132963237_ENST00000372398_length(transcript)=5751nt_BP=910nt
GCTTATAACCTGGGATGGGCACCCCTGCCAGTCCTGCTCTGCCGCCTGCCACCGCTGCCCGAGCCCGACGCTATGTCCAGCAAAGGCTCC
GTGGTTCTGGCCTACAGTGGCGGCCTGGACACCTCGTGCATCCTCGTGTGGCTGAAGGAACAAGGCTATGACGTCATTGCCTATCTGGCC
AACATTGGCCAGAAGGAAGACTTCGAGGAAGCCAGGAAGAAGGCACTGAAGCTTGGGGCCAAAAAGGTGTTCATTGAGGATGTCAGCAGG
GAGTTTGTGGAGGAGTTCATCTGGCCGGCCATCCAGTCCAGCGCACTGTATGAGGACCGCTACCTCCTGGGCACCTCTCTTGCCAGGCCC
TGCATCGCCCGCAAACAAGTGGAAATCGCCCAGCGGGAGGGGGCCAAGTATGTGTCCCACGGCGCCACAGGAAAGGGGAACGATCAGGTC
CGGTTTGAGCTCAGCTGCTACTCACTGGCCCCCCAGATAAAGGTCATTGCTCCCTGGAGGATGCCTGAATTCTACAACCGGTTCAAGGGC
CGCAATGACCTGATGGAGTACGCAAAGCAACACGGGATTCCCATCCCGGTCACTCCCAAGAACCCGTGGAGCATGGATGAGAACCTCATG
CACATCAGCTACGAGGCTGGAATCCTGGAGAACCCCAAGAACCAAGCGCCTCCAGGTCTCTACACGAAGACCCAGGACCCAGCCAAAGCC
CCCAACACCCCTGACATTCTCGAGATCGAGTTCAAAAAAGGGGTCCCTGTGAAGGTGACCAACGTCAAGGATGGCACCACCCACCAGACC
TCCTTGGAGCTCTTCATGTACCTGAACGAAGTCGCGGGCAAGCATGGCGTGGGCCGTATTGACATCGTGGAGAACCGCTTCATTGGAATG
AAGTCCCGAGTTACCGAGAAGGAGGTCCAGCAGTGGTACAAAGGCTTCATCAAGGACTGCCCCAGTGGGCAGCTGGATGCGGCAGGCTTC
CAGAAGATCTACAAGCAATTCTTCCCGTTCGGAGACCCCACCAAGTTTGCCACATTTGTTTTCAACGTCTTTGATGAAAACAAGGACGGG
CGAATTGAGTTCTCCGAGTTCATCCAGGCGCTGTCGGTGACCTCACGGGGAACCCTGGATGAGAAGCTACGGTGGGCCTTCAAGCTCTAC
GACTTGGACAATGATGGCTACATCACCAGGAATGAGATGCTGGACATTGTGGATGCCATTTACCAGATGGTGGGGAATACCGTGGAGCTC
CCAGAGGAGGAGAACACTCCTGAGAAGAGGGTGGACCGGATCTTTGCCATGATGGATAAGAATGCCGACGGGAAGCTGACCCTGCAGGAG
TTCCAGGAGGGTTCCAAGGCAGACCCGTCCATTGTGCAGGCGCTGTCCCTCTACGACGGGCTGGTATAGTCCCAGGCTGGAGCTGGATGC
CTGGGAACCACTCACCTCCTTCTGTGCCATGAGGCCACCTCAGCCCTGACACCAACCCCGTGCGTCCACCCAGCCTTCTTCCGCATCCAC
ACACAGCCGGCTGCCCTTGACCCGGGAGGCCCCGGCTCTCCTCTCCCCTGTCCTGCACCCATCCCCCGCCTGAAGCCACCGGCTCCAATT
GCCAGCAACCTCTGCTTGTCCGGAAAACGACAACACGAAATGGAAAAGGCTACAGCCCTCTGCATAAACCAAGGACTTGGCTGCCTCGCA
GGCAGCCTCCGTTCCTCCCGCTCTCTTGCGCGTGTGCTTTTGTTTTTTATTTTGAACAGACGTTTTAAAAGAAAAAAAAACAACTACCTT
CTGTCCTAGAAGACACAGACTGACAGATGGGGTGAAGGCCTGGGGACCTCAGAGAACTCTGCCTTGCCCTCGTCCCTCGTCCTTCGGCAG
CCGGAGAGGCTGTGGGTGGGCCGAGGGTGTCTAGGGGTTCTGCCTGGTCAACGTTATTTGTCGTCCCATCTTTTGGCAGCAAAACCACCT
GCGTGGCTAGGATGATTAATTATGAGGATGATGATTTTTTTTGTGATAACAGTATTGTGCTTTTTGTGGGGAAAGTGAGGTTTTTTTTTA
TATACATATATAATTGATATCTTTAATTTATTGGTTGTTAACTGTTGCTGCTGCCTGGTGTGTCCTCAGCTCCCAGGGCTGCGGGCCCAC
CGTTTACATGTGCACGCCCTGACCCACCTGCCCACGCCGACTTGGGAGGATGGTGGCCTGCAGCGGCCAAGAAGCCAAAAAAAATTTTTT
TTTTTTCAGATACTGTGCTTGATTTTTGGAGAGGGGAGAGGTGGAAATTCCTAAATGGCTAATGCACTGTTCCCTCCAGCCCGAATGCCT
CCTGCCAAACCCCTTTTCCCTGCTGCCTCTGTCCCCGCATCCTTGTTCTCCCCTGGGTCCGTAACATTTTTTCCGAGGATGAACAGGGGA
CATCTTTAGGTTTCTCAACTCTTGCTTTGGTGTTTGCCGCAGCATGGAAAACAGGGCGCCTAAGGCTGGGAGCTGGAAGAAGGGGCATTG
GGTACCCAGGCAGAGTCAGGAGAGGTGGTCTTTGAAGTAAGTTAGCAGAAATCAAGGGGACCCCCGCCTCCTTGGGCTGGGGAGGGGATT
TCAAGATAGTTCATGACTCTCTCCCGCTCTGCCTTCCCTCCTTCCTATCTGCTTTTTCCAGTAAACTGCATGGTGTCCTTCCCTGGCCTT
CTCTTGGCTCAAAGGCTGGGAGGGAGGGAAGGAGAGAAGAGTTCCAGGCAATCCCATCAATATAGTCCCTACACCTGGGGCTGCGGCCCA
CATGTCTTCACGGAGGCTTCCAGCGGTGCCTGCCACTGAGGCAGGTGCGGCCCCAGGACCATCACCAGGAATGCGAGGCCACCCTGGACC
AGAGGTAGGAGCCCAAGGTCCGGCCCTTGCTCTTTGATTGTGGGCAGCCTCCTGCCCTCTCTGGGTCTCAGTTGCCCCATCTGCAGAGCG
AGGAGGCCCGGGCTGGTTGGTCTTGAAGGCCCTTTTCCATGCCGACATCATGTCACTCTAGGCCTGGGGTTCAGTTTCCTGTGGCTGGTG
ATGCTGTGGTTAAGTTTGCTTGACCCCAGCAGCCCGAGGGACTGTCTGAGTCACAGCACAGCCCCTATTGCGTGGCTGCTGGTGTGTGGG
GTCAGTTCCAGCAGATGAATGTGTCATGTGGCACACCTTGTCCCTTCCCGCAGCATTTCCTGGTTCCCCCCAGACCCTTGAGCGCTCTTT
GGGACCCAGAAGGAGTCCTTGCACAGGGAAGGCTTGAGGTGAGAAGCCGCTTCCCAGACTGTCAGGGCCAGGCCTGGGTCTAGAATTCTT
GCTGCTGCTTTGCAGAGTCAACAGCCCATCAGCCCATGTTTTAGAGGGGACACTTTGGTCCTCGGTTCCCACCCTCAGCAAGCAGGCCTC
CAGCCCGAGGAAGGCCTCTGCCGTAGTGACGTTGCCGTGTGGGGCTGCGTGGCTGTTCCCCTTGGCTGGAGCATTCAGCCAACCCCAGCG
TCCCCCCTGAGGCGTTCATTGGCAGCCCCCTAGGACTGCACGCTGGCCCCACGGTAACCCCCCCTCCCCCACCAACATCCTGCAGGGATG
GGGTCAGTGGTTCCACCTTCACAGGCCACTTTGAAGGGTGGATTCTTTGAGGCCCCTGCCAGTCGGCTCCCTGCTCAGCTGCTGGCCCGG
GCGACCTGGGACTCAGCACCAACGGCTGAAGTTTCTCAGCTGGGCTCTGACCTGGGGTCTGGGGCAGGGAACGAACATGGTGGCTTTGGG
CTGAGAGGATGAGGGAGGTCTTTCCCAGGTCAAATTACTTTCCTTTGGCCTCTGCCTGAGGCTCGATTTGCCTCTCTGGTCCAATGGGAC
TGACACTGTTGTACAACCTGACCTGTGGCTGAGGGTGTCTGGGCTTAAGCATGTGGACCCCTTCGGTGTGTCCGGCCTTCCTCCATCGTC
CTGCCCTTTGGCCTTTTGGTTTGAAGCCACAGGTGTGGCTTCTGGCCTTAGCAGATGGTATGCTTGCGGACCGCAGCCCAGCATGCCGGT
GGGCCCACAGCCCGAGCCAGCCCAGAGCTGCCGGAAGGGCCGCCCTTCCCGGCCCTGGCGGGGTGCTGGACACTGGCCATTTTCACTAGA
GTTTGCCTGGCAGGGACCGATCTCTGCCCCCTCCTCTCCCCAGGCCTCTGGCTGCAGTGATGCCGCAGAATCCTGAGCCAGGTGCCTCCT
GAGCAGCCCGTGCGCCTCTCCACAGCGGCGTTTGCCACCCAATGCGGCTCGCTTCAGATGCTCTGATGCAGAGGGCACGCCCATAGTCCC
TCTGCAGAGCCTCGCACTGGGGCCAGGGCAGGCACCAGCCCCAGGCGGCCAGTCGGCCACGGCCTGTCCTCTTCCTCGTAGCGTCTGCTC
CTCACTTTGTGTTGATGGTGACTTAGGAGAATGTTCCGATTTTCCATGATCTAAGCAGGCCACGTTTAAAATAACATCAAGGCAAGCGTA
CGTGTCACCCTCTGTACTGACATCTCTTCCCCTGAAATGCTTTTCAGTTTGACAGCCCGTTTCCTAGACAAGTGCACCTGGGGTTTCAGG
AACTTTGTGTTTTTTCGGAGGGGGTTGGTGGGGAGGTCGGGATGCCTGGGATCCCTTCCTGGAGAGGCAGGCTGTCTCTGGAAAAAGCCT
CCATTGCCCACCCGCCAGGCGGAAAGTCACCCTGTTCCCAGCGCGGTTTCAGCATTTAATTTTAAGGGAGCTAAGGAAGCGCGGCGCGCC
CCCTGGTGGTGGTAAGCCGCCAACGCACCTGGGGGCTGCAACCCCACCGGACGGGTGGTCCGGAGGGAGGCTGGAGCGGGGAGGCGAGGA
GGGGGCTGTGAGTCCTCAGAGGCCCTGGGCCACCACATTTCTGGCAGCGTTTCCCAGACACCCCTCTGCTAGGCCATCCCTGGATAGCAA
GTGAATTAACTTAAGGGCACTGTGATGGGAAGCCTTGCCCCCCTCTTTTTTTTTTTTTTTTAATATCTGCGGAATAAACCCAATGGTTAA
TTTTTGAATGAATAAAAGGCTTTTGTTGAATAAACAGCTGGTCCCATCTTCTGTCTTGGCATCTTAGCATCCAGGCTCAGGCTCTGCCCC
TTCTCCAGGATGGGGTAGCCCCGAGTCGCCCTCCCCAGTCTGCACATTCCCTGTTGTCCCTGTTCCTGCAGTGGCTCCCGGCCCCAGGGA
GGCCCACCTCACTCCCAGCCTGACTCGGTGGCTGGCTTCCTTCAGGACTTTGCGCAAGTCAGTTCTGCTCATTGGGTCTCAATTTCCCCA
TCCCTTGGATGGGAGCAAGAGTCTCTGCTGGGCCTGCCTCGCAGGGGCCTGGTGAGACCCAAATGTGAGTGTCATCATCAAAGCCCCTCA
CAGAAGTGGAGGACGGTGCCCAAGAGTAGCGGTTTGGACTGCTGCTGCCTCCCACCCGGAGCCTGCCACTTGGGGGAGAAATTGGTATAA
TGCTTGCAAAAACAAACAAACAAAAGGCAATGTCTTCTGGTTGTGGTTATTTCCTTTCCTGCTTGCCTCCCCAGCCCCCTTTGAGTCTCT
TTTTGGGGTGCCGTCCTGTCTGAACCTGCCGGTGTGTGTCTCTGGGGCCAGGGTCAGGGCGAGGCCCAGGGGTGGACAGGGGCCGTGTAG

>7258_7258_1_ASS1-NCS1_ASS1_chr9_133355836_ENST00000352480_NCS1_chr9_132963237_ENST00000372398_length(amino acids)=469AA_BP=300
MGWAPLPVLLCRLPPLPEPDAMSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSREFV
EEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRND
LMEYAKQHGIPIPVTPKNPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDGTTHQTSLE
LFMYLNEVAGKHGVGRIDIVENRFIGMKSRVTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIE
FSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQE

--------------------------------------------------------------
>7258_7258_2_ASS1-NCS1_ASS1_chr9_133355836_ENST00000372393_NCS1_chr9_132963237_ENST00000372398_length(transcript)=5754nt_BP=913nt
CGAGCCCGAGTGGTTCACTGCACTGTGAAAACAGATTCCAGACGCCGGGAACTCACGCCTCCAATCCCAGACGCTATGTCCAGCAAAGGC
TCCGTGGTTCTGGCCTACAGTGGCGGCCTGGACACCTCGTGCATCCTCGTGTGGCTGAAGGAACAAGGCTATGACGTCATTGCCTATCTG
GCCAACATTGGCCAGAAGGAAGACTTCGAGGAAGCCAGGAAGAAGGCACTGAAGCTTGGGGCCAAAAAGGTGTTCATTGAGGATGTCAGC
AGGGAGTTTGTGGAGGAGTTCATCTGGCCGGCCATCCAGTCCAGCGCACTGTATGAGGACCGCTACCTCCTGGGCACCTCTCTTGCCAGG
CCCTGCATCGCCCGCAAACAAGTGGAAATCGCCCAGCGGGAGGGGGCCAAGTATGTGTCCCACGGCGCCACAGGAAAGGGGAACGATCAG
GTCCGGTTTGAGCTCAGCTGCTACTCACTGGCCCCCCAGATAAAGGTCATTGCTCCCTGGAGGATGCCTGAATTCTACAACCGGTTCAAG
GGCCGCAATGACCTGATGGAGTACGCAAAGCAACACGGGATTCCCATCCCGGTCACTCCCAAGAACCCGTGGAGCATGGATGAGAACCTC
ATGCACATCAGCTACGAGGCTGGAATCCTGGAGAACCCCAAGAACCAAGCGCCTCCAGGTCTCTACACGAAGACCCAGGACCCAGCCAAA
GCCCCCAACACCCCTGACATTCTCGAGATCGAGTTCAAAAAAGGGGTCCCTGTGAAGGTGACCAACGTCAAGGATGGCACCACCCACCAG
ACCTCCTTGGAGCTCTTCATGTACCTGAACGAAGTCGCGGGCAAGCATGGCGTGGGCCGTATTGACATCGTGGAGAACCGCTTCATTGGA
ATGAAGTCCCGAGTTACCGAGAAGGAGGTCCAGCAGTGGTACAAAGGCTTCATCAAGGACTGCCCCAGTGGGCAGCTGGATGCGGCAGGC
TTCCAGAAGATCTACAAGCAATTCTTCCCGTTCGGAGACCCCACCAAGTTTGCCACATTTGTTTTCAACGTCTTTGATGAAAACAAGGAC
GGGCGAATTGAGTTCTCCGAGTTCATCCAGGCGCTGTCGGTGACCTCACGGGGAACCCTGGATGAGAAGCTACGGTGGGCCTTCAAGCTC
TACGACTTGGACAATGATGGCTACATCACCAGGAATGAGATGCTGGACATTGTGGATGCCATTTACCAGATGGTGGGGAATACCGTGGAG
CTCCCAGAGGAGGAGAACACTCCTGAGAAGAGGGTGGACCGGATCTTTGCCATGATGGATAAGAATGCCGACGGGAAGCTGACCCTGCAG
GAGTTCCAGGAGGGTTCCAAGGCAGACCCGTCCATTGTGCAGGCGCTGTCCCTCTACGACGGGCTGGTATAGTCCCAGGCTGGAGCTGGA
TGCCTGGGAACCACTCACCTCCTTCTGTGCCATGAGGCCACCTCAGCCCTGACACCAACCCCGTGCGTCCACCCAGCCTTCTTCCGCATC
CACACACAGCCGGCTGCCCTTGACCCGGGAGGCCCCGGCTCTCCTCTCCCCTGTCCTGCACCCATCCCCCGCCTGAAGCCACCGGCTCCA
ATTGCCAGCAACCTCTGCTTGTCCGGAAAACGACAACACGAAATGGAAAAGGCTACAGCCCTCTGCATAAACCAAGGACTTGGCTGCCTC
GCAGGCAGCCTCCGTTCCTCCCGCTCTCTTGCGCGTGTGCTTTTGTTTTTTATTTTGAACAGACGTTTTAAAAGAAAAAAAAACAACTAC
CTTCTGTCCTAGAAGACACAGACTGACAGATGGGGTGAAGGCCTGGGGACCTCAGAGAACTCTGCCTTGCCCTCGTCCCTCGTCCTTCGG
CAGCCGGAGAGGCTGTGGGTGGGCCGAGGGTGTCTAGGGGTTCTGCCTGGTCAACGTTATTTGTCGTCCCATCTTTTGGCAGCAAAACCA
CCTGCGTGGCTAGGATGATTAATTATGAGGATGATGATTTTTTTTGTGATAACAGTATTGTGCTTTTTGTGGGGAAAGTGAGGTTTTTTT
TTATATACATATATAATTGATATCTTTAATTTATTGGTTGTTAACTGTTGCTGCTGCCTGGTGTGTCCTCAGCTCCCAGGGCTGCGGGCC
CACCGTTTACATGTGCACGCCCTGACCCACCTGCCCACGCCGACTTGGGAGGATGGTGGCCTGCAGCGGCCAAGAAGCCAAAAAAAATTT
TTTTTTTTTCAGATACTGTGCTTGATTTTTGGAGAGGGGAGAGGTGGAAATTCCTAAATGGCTAATGCACTGTTCCCTCCAGCCCGAATG
CCTCCTGCCAAACCCCTTTTCCCTGCTGCCTCTGTCCCCGCATCCTTGTTCTCCCCTGGGTCCGTAACATTTTTTCCGAGGATGAACAGG
GGACATCTTTAGGTTTCTCAACTCTTGCTTTGGTGTTTGCCGCAGCATGGAAAACAGGGCGCCTAAGGCTGGGAGCTGGAAGAAGGGGCA
TTGGGTACCCAGGCAGAGTCAGGAGAGGTGGTCTTTGAAGTAAGTTAGCAGAAATCAAGGGGACCCCCGCCTCCTTGGGCTGGGGAGGGG
ATTTCAAGATAGTTCATGACTCTCTCCCGCTCTGCCTTCCCTCCTTCCTATCTGCTTTTTCCAGTAAACTGCATGGTGTCCTTCCCTGGC
CTTCTCTTGGCTCAAAGGCTGGGAGGGAGGGAAGGAGAGAAGAGTTCCAGGCAATCCCATCAATATAGTCCCTACACCTGGGGCTGCGGC
CCACATGTCTTCACGGAGGCTTCCAGCGGTGCCTGCCACTGAGGCAGGTGCGGCCCCAGGACCATCACCAGGAATGCGAGGCCACCCTGG
ACCAGAGGTAGGAGCCCAAGGTCCGGCCCTTGCTCTTTGATTGTGGGCAGCCTCCTGCCCTCTCTGGGTCTCAGTTGCCCCATCTGCAGA
GCGAGGAGGCCCGGGCTGGTTGGTCTTGAAGGCCCTTTTCCATGCCGACATCATGTCACTCTAGGCCTGGGGTTCAGTTTCCTGTGGCTG
GTGATGCTGTGGTTAAGTTTGCTTGACCCCAGCAGCCCGAGGGACTGTCTGAGTCACAGCACAGCCCCTATTGCGTGGCTGCTGGTGTGT
GGGGTCAGTTCCAGCAGATGAATGTGTCATGTGGCACACCTTGTCCCTTCCCGCAGCATTTCCTGGTTCCCCCCAGACCCTTGAGCGCTC
TTTGGGACCCAGAAGGAGTCCTTGCACAGGGAAGGCTTGAGGTGAGAAGCCGCTTCCCAGACTGTCAGGGCCAGGCCTGGGTCTAGAATT
CTTGCTGCTGCTTTGCAGAGTCAACAGCCCATCAGCCCATGTTTTAGAGGGGACACTTTGGTCCTCGGTTCCCACCCTCAGCAAGCAGGC
CTCCAGCCCGAGGAAGGCCTCTGCCGTAGTGACGTTGCCGTGTGGGGCTGCGTGGCTGTTCCCCTTGGCTGGAGCATTCAGCCAACCCCA
GCGTCCCCCCTGAGGCGTTCATTGGCAGCCCCCTAGGACTGCACGCTGGCCCCACGGTAACCCCCCCTCCCCCACCAACATCCTGCAGGG
ATGGGGTCAGTGGTTCCACCTTCACAGGCCACTTTGAAGGGTGGATTCTTTGAGGCCCCTGCCAGTCGGCTCCCTGCTCAGCTGCTGGCC
CGGGCGACCTGGGACTCAGCACCAACGGCTGAAGTTTCTCAGCTGGGCTCTGACCTGGGGTCTGGGGCAGGGAACGAACATGGTGGCTTT
GGGCTGAGAGGATGAGGGAGGTCTTTCCCAGGTCAAATTACTTTCCTTTGGCCTCTGCCTGAGGCTCGATTTGCCTCTCTGGTCCAATGG
GACTGACACTGTTGTACAACCTGACCTGTGGCTGAGGGTGTCTGGGCTTAAGCATGTGGACCCCTTCGGTGTGTCCGGCCTTCCTCCATC
GTCCTGCCCTTTGGCCTTTTGGTTTGAAGCCACAGGTGTGGCTTCTGGCCTTAGCAGATGGTATGCTTGCGGACCGCAGCCCAGCATGCC
GGTGGGCCCACAGCCCGAGCCAGCCCAGAGCTGCCGGAAGGGCCGCCCTTCCCGGCCCTGGCGGGGTGCTGGACACTGGCCATTTTCACT
AGAGTTTGCCTGGCAGGGACCGATCTCTGCCCCCTCCTCTCCCCAGGCCTCTGGCTGCAGTGATGCCGCAGAATCCTGAGCCAGGTGCCT
CCTGAGCAGCCCGTGCGCCTCTCCACAGCGGCGTTTGCCACCCAATGCGGCTCGCTTCAGATGCTCTGATGCAGAGGGCACGCCCATAGT
CCCTCTGCAGAGCCTCGCACTGGGGCCAGGGCAGGCACCAGCCCCAGGCGGCCAGTCGGCCACGGCCTGTCCTCTTCCTCGTAGCGTCTG
CTCCTCACTTTGTGTTGATGGTGACTTAGGAGAATGTTCCGATTTTCCATGATCTAAGCAGGCCACGTTTAAAATAACATCAAGGCAAGC
GTACGTGTCACCCTCTGTACTGACATCTCTTCCCCTGAAATGCTTTTCAGTTTGACAGCCCGTTTCCTAGACAAGTGCACCTGGGGTTTC
AGGAACTTTGTGTTTTTTCGGAGGGGGTTGGTGGGGAGGTCGGGATGCCTGGGATCCCTTCCTGGAGAGGCAGGCTGTCTCTGGAAAAAG
CCTCCATTGCCCACCCGCCAGGCGGAAAGTCACCCTGTTCCCAGCGCGGTTTCAGCATTTAATTTTAAGGGAGCTAAGGAAGCGCGGCGC
GCCCCCTGGTGGTGGTAAGCCGCCAACGCACCTGGGGGCTGCAACCCCACCGGACGGGTGGTCCGGAGGGAGGCTGGAGCGGGGAGGCGA
GGAGGGGGCTGTGAGTCCTCAGAGGCCCTGGGCCACCACATTTCTGGCAGCGTTTCCCAGACACCCCTCTGCTAGGCCATCCCTGGATAG
CAAGTGAATTAACTTAAGGGCACTGTGATGGGAAGCCTTGCCCCCCTCTTTTTTTTTTTTTTTTAATATCTGCGGAATAAACCCAATGGT
TAATTTTTGAATGAATAAAAGGCTTTTGTTGAATAAACAGCTGGTCCCATCTTCTGTCTTGGCATCTTAGCATCCAGGCTCAGGCTCTGC
CCCTTCTCCAGGATGGGGTAGCCCCGAGTCGCCCTCCCCAGTCTGCACATTCCCTGTTGTCCCTGTTCCTGCAGTGGCTCCCGGCCCCAG
GGAGGCCCACCTCACTCCCAGCCTGACTCGGTGGCTGGCTTCCTTCAGGACTTTGCGCAAGTCAGTTCTGCTCATTGGGTCTCAATTTCC
CCATCCCTTGGATGGGAGCAAGAGTCTCTGCTGGGCCTGCCTCGCAGGGGCCTGGTGAGACCCAAATGTGAGTGTCATCATCAAAGCCCC
TCACAGAAGTGGAGGACGGTGCCCAAGAGTAGCGGTTTGGACTGCTGCTGCCTCCCACCCGGAGCCTGCCACTTGGGGGAGAAATTGGTA
TAATGCTTGCAAAAACAAACAAACAAAAGGCAATGTCTTCTGGTTGTGGTTATTTCCTTTCCTGCTTGCCTCCCCAGCCCCCTTTGAGTC
TCTTTTTGGGGTGCCGTCCTGTCTGAACCTGCCGGTGTGTGTCTCTGGGGCCAGGGTCAGGGCGAGGCCCAGGGGTGGACAGGGGCCGTG

>7258_7258_2_ASS1-NCS1_ASS1_chr9_133355836_ENST00000372393_NCS1_chr9_132963237_ENST00000372398_length(amino acids)=448AA_BP=279
MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSREFVEEFIWPAIQSSALYEDRYLLG
TSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWS
MDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDGTTHQTSLELFMYLNEVAGKHGVGRIDIVE
NRFIGMKSRVTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLR

--------------------------------------------------------------
>7258_7258_3_ASS1-NCS1_ASS1_chr9_133355836_ENST00000372394_NCS1_chr9_132963237_ENST00000372398_length(transcript)=6160nt_BP=1319nt
CTGCTCTGCCGCCTGCCACCGCTGCCCGAGCCCGGTGGGCGGCGGCACTGCGTGCTGGGGAAGCACAGATTCTTGTGCCCTCTGTGACCT
TGAGCCTGCCACTGACCTCTCTGAGCCCTGCTGGCTGCCTCCCCAATAGGAATGACAACTCCTACTTCATGAGGTTGTAGTGGGGGCTCA
GGGGCACAGGGAGATCCCGCTGAGGCTCCCAGGGCCCTGCCTGGTGCTTGGCAAGGAGCAGTTCTGATGGGGGATGTGTCAGCTGCCAGA
GGCTCAGAGCCAAGGCCCCTCCCACATCTCCTGCCTGCGTGCATTCCTCACATCCTGGCCTTGGGCCAAACTGCTCAGCCTCAGCCGCCT
TCCCTCGATGCTGGAGGATCAGGTCCAAGAGATGCCTCTCCCCGACCAGCCTAGGACTGCAGTCAGCATTCCCAGGCCCCAGTGTGGTCT
GTGGGGCTGTGTGCAGAGTGTGCGAGACGCTATGTCCAGCAAAGGCTCCGTGGTTCTGGCCTACAGTGGCGGCCTGGACACCTCGTGCAT
CCTCGTGTGGCTGAAGGAACAAGGCTATGACGTCATTGCCTATCTGGCCAACATTGGCCAGAAGGAAGACTTCGAGGAAGCCAGGAAGAA
GGCACTGAAGCTTGGGGCCAAAAAGGTGTTCATTGAGGATGTCAGCAGGGAGTTTGTGGAGGAGTTCATCTGGCCGGCCATCCAGTCCAG
CGCACTGTATGAGGACCGCTACCTCCTGGGCACCTCTCTTGCCAGGCCCTGCATCGCCCGCAAACAAGTGGAAATCGCCCAGCGGGAGGG
GGCCAAGTATGTGTCCCACGGCGCCACAGGAAAGGGGAACGATCAGGTCCGGTTTGAGCTCAGCTGCTACTCACTGGCCCCCCAGATAAA
GGTCATTGCTCCCTGGAGGATGCCTGAATTCTACAACCGGTTCAAGGGCCGCAATGACCTGATGGAGTACGCAAAGCAACACGGGATTCC
CATCCCGGTCACTCCCAAGAACCCGTGGAGCATGGATGAGAACCTCATGCACATCAGCTACGAGGCTGGAATCCTGGAGAACCCCAAGAA
CCAAGCGCCTCCAGGTCTCTACACGAAGACCCAGGACCCAGCCAAAGCCCCCAACACCCCTGACATTCTCGAGATCGAGTTCAAAAAAGG
GGTCCCTGTGAAGGTGACCAACGTCAAGGATGGCACCACCCACCAGACCTCCTTGGAGCTCTTCATGTACCTGAACGAAGTCGCGGGCAA
GCATGGCGTGGGCCGTATTGACATCGTGGAGAACCGCTTCATTGGAATGAAGTCCCGAGTTACCGAGAAGGAGGTCCAGCAGTGGTACAA
AGGCTTCATCAAGGACTGCCCCAGTGGGCAGCTGGATGCGGCAGGCTTCCAGAAGATCTACAAGCAATTCTTCCCGTTCGGAGACCCCAC
CAAGTTTGCCACATTTGTTTTCAACGTCTTTGATGAAAACAAGGACGGGCGAATTGAGTTCTCCGAGTTCATCCAGGCGCTGTCGGTGAC
CTCACGGGGAACCCTGGATGAGAAGCTACGGTGGGCCTTCAAGCTCTACGACTTGGACAATGATGGCTACATCACCAGGAATGAGATGCT
GGACATTGTGGATGCCATTTACCAGATGGTGGGGAATACCGTGGAGCTCCCAGAGGAGGAGAACACTCCTGAGAAGAGGGTGGACCGGAT
CTTTGCCATGATGGATAAGAATGCCGACGGGAAGCTGACCCTGCAGGAGTTCCAGGAGGGTTCCAAGGCAGACCCGTCCATTGTGCAGGC
GCTGTCCCTCTACGACGGGCTGGTATAGTCCCAGGCTGGAGCTGGATGCCTGGGAACCACTCACCTCCTTCTGTGCCATGAGGCCACCTC
AGCCCTGACACCAACCCCGTGCGTCCACCCAGCCTTCTTCCGCATCCACACACAGCCGGCTGCCCTTGACCCGGGAGGCCCCGGCTCTCC
TCTCCCCTGTCCTGCACCCATCCCCCGCCTGAAGCCACCGGCTCCAATTGCCAGCAACCTCTGCTTGTCCGGAAAACGACAACACGAAAT
GGAAAAGGCTACAGCCCTCTGCATAAACCAAGGACTTGGCTGCCTCGCAGGCAGCCTCCGTTCCTCCCGCTCTCTTGCGCGTGTGCTTTT
GTTTTTTATTTTGAACAGACGTTTTAAAAGAAAAAAAAACAACTACCTTCTGTCCTAGAAGACACAGACTGACAGATGGGGTGAAGGCCT
GGGGACCTCAGAGAACTCTGCCTTGCCCTCGTCCCTCGTCCTTCGGCAGCCGGAGAGGCTGTGGGTGGGCCGAGGGTGTCTAGGGGTTCT
GCCTGGTCAACGTTATTTGTCGTCCCATCTTTTGGCAGCAAAACCACCTGCGTGGCTAGGATGATTAATTATGAGGATGATGATTTTTTT
TGTGATAACAGTATTGTGCTTTTTGTGGGGAAAGTGAGGTTTTTTTTTATATACATATATAATTGATATCTTTAATTTATTGGTTGTTAA
CTGTTGCTGCTGCCTGGTGTGTCCTCAGCTCCCAGGGCTGCGGGCCCACCGTTTACATGTGCACGCCCTGACCCACCTGCCCACGCCGAC
TTGGGAGGATGGTGGCCTGCAGCGGCCAAGAAGCCAAAAAAAATTTTTTTTTTTTCAGATACTGTGCTTGATTTTTGGAGAGGGGAGAGG
TGGAAATTCCTAAATGGCTAATGCACTGTTCCCTCCAGCCCGAATGCCTCCTGCCAAACCCCTTTTCCCTGCTGCCTCTGTCCCCGCATC
CTTGTTCTCCCCTGGGTCCGTAACATTTTTTCCGAGGATGAACAGGGGACATCTTTAGGTTTCTCAACTCTTGCTTTGGTGTTTGCCGCA
GCATGGAAAACAGGGCGCCTAAGGCTGGGAGCTGGAAGAAGGGGCATTGGGTACCCAGGCAGAGTCAGGAGAGGTGGTCTTTGAAGTAAG
TTAGCAGAAATCAAGGGGACCCCCGCCTCCTTGGGCTGGGGAGGGGATTTCAAGATAGTTCATGACTCTCTCCCGCTCTGCCTTCCCTCC
TTCCTATCTGCTTTTTCCAGTAAACTGCATGGTGTCCTTCCCTGGCCTTCTCTTGGCTCAAAGGCTGGGAGGGAGGGAAGGAGAGAAGAG
TTCCAGGCAATCCCATCAATATAGTCCCTACACCTGGGGCTGCGGCCCACATGTCTTCACGGAGGCTTCCAGCGGTGCCTGCCACTGAGG
CAGGTGCGGCCCCAGGACCATCACCAGGAATGCGAGGCCACCCTGGACCAGAGGTAGGAGCCCAAGGTCCGGCCCTTGCTCTTTGATTGT
GGGCAGCCTCCTGCCCTCTCTGGGTCTCAGTTGCCCCATCTGCAGAGCGAGGAGGCCCGGGCTGGTTGGTCTTGAAGGCCCTTTTCCATG
CCGACATCATGTCACTCTAGGCCTGGGGTTCAGTTTCCTGTGGCTGGTGATGCTGTGGTTAAGTTTGCTTGACCCCAGCAGCCCGAGGGA
CTGTCTGAGTCACAGCACAGCCCCTATTGCGTGGCTGCTGGTGTGTGGGGTCAGTTCCAGCAGATGAATGTGTCATGTGGCACACCTTGT
CCCTTCCCGCAGCATTTCCTGGTTCCCCCCAGACCCTTGAGCGCTCTTTGGGACCCAGAAGGAGTCCTTGCACAGGGAAGGCTTGAGGTG
AGAAGCCGCTTCCCAGACTGTCAGGGCCAGGCCTGGGTCTAGAATTCTTGCTGCTGCTTTGCAGAGTCAACAGCCCATCAGCCCATGTTT
TAGAGGGGACACTTTGGTCCTCGGTTCCCACCCTCAGCAAGCAGGCCTCCAGCCCGAGGAAGGCCTCTGCCGTAGTGACGTTGCCGTGTG
GGGCTGCGTGGCTGTTCCCCTTGGCTGGAGCATTCAGCCAACCCCAGCGTCCCCCCTGAGGCGTTCATTGGCAGCCCCCTAGGACTGCAC
GCTGGCCCCACGGTAACCCCCCCTCCCCCACCAACATCCTGCAGGGATGGGGTCAGTGGTTCCACCTTCACAGGCCACTTTGAAGGGTGG
ATTCTTTGAGGCCCCTGCCAGTCGGCTCCCTGCTCAGCTGCTGGCCCGGGCGACCTGGGACTCAGCACCAACGGCTGAAGTTTCTCAGCT
GGGCTCTGACCTGGGGTCTGGGGCAGGGAACGAACATGGTGGCTTTGGGCTGAGAGGATGAGGGAGGTCTTTCCCAGGTCAAATTACTTT
CCTTTGGCCTCTGCCTGAGGCTCGATTTGCCTCTCTGGTCCAATGGGACTGACACTGTTGTACAACCTGACCTGTGGCTGAGGGTGTCTG
GGCTTAAGCATGTGGACCCCTTCGGTGTGTCCGGCCTTCCTCCATCGTCCTGCCCTTTGGCCTTTTGGTTTGAAGCCACAGGTGTGGCTT
CTGGCCTTAGCAGATGGTATGCTTGCGGACCGCAGCCCAGCATGCCGGTGGGCCCACAGCCCGAGCCAGCCCAGAGCTGCCGGAAGGGCC
GCCCTTCCCGGCCCTGGCGGGGTGCTGGACACTGGCCATTTTCACTAGAGTTTGCCTGGCAGGGACCGATCTCTGCCCCCTCCTCTCCCC
AGGCCTCTGGCTGCAGTGATGCCGCAGAATCCTGAGCCAGGTGCCTCCTGAGCAGCCCGTGCGCCTCTCCACAGCGGCGTTTGCCACCCA
ATGCGGCTCGCTTCAGATGCTCTGATGCAGAGGGCACGCCCATAGTCCCTCTGCAGAGCCTCGCACTGGGGCCAGGGCAGGCACCAGCCC
CAGGCGGCCAGTCGGCCACGGCCTGTCCTCTTCCTCGTAGCGTCTGCTCCTCACTTTGTGTTGATGGTGACTTAGGAGAATGTTCCGATT
TTCCATGATCTAAGCAGGCCACGTTTAAAATAACATCAAGGCAAGCGTACGTGTCACCCTCTGTACTGACATCTCTTCCCCTGAAATGCT
TTTCAGTTTGACAGCCCGTTTCCTAGACAAGTGCACCTGGGGTTTCAGGAACTTTGTGTTTTTTCGGAGGGGGTTGGTGGGGAGGTCGGG
ATGCCTGGGATCCCTTCCTGGAGAGGCAGGCTGTCTCTGGAAAAAGCCTCCATTGCCCACCCGCCAGGCGGAAAGTCACCCTGTTCCCAG
CGCGGTTTCAGCATTTAATTTTAAGGGAGCTAAGGAAGCGCGGCGCGCCCCCTGGTGGTGGTAAGCCGCCAACGCACCTGGGGGCTGCAA
CCCCACCGGACGGGTGGTCCGGAGGGAGGCTGGAGCGGGGAGGCGAGGAGGGGGCTGTGAGTCCTCAGAGGCCCTGGGCCACCACATTTC
TGGCAGCGTTTCCCAGACACCCCTCTGCTAGGCCATCCCTGGATAGCAAGTGAATTAACTTAAGGGCACTGTGATGGGAAGCCTTGCCCC
CCTCTTTTTTTTTTTTTTTTAATATCTGCGGAATAAACCCAATGGTTAATTTTTGAATGAATAAAAGGCTTTTGTTGAATAAACAGCTGG
TCCCATCTTCTGTCTTGGCATCTTAGCATCCAGGCTCAGGCTCTGCCCCTTCTCCAGGATGGGGTAGCCCCGAGTCGCCCTCCCCAGTCT
GCACATTCCCTGTTGTCCCTGTTCCTGCAGTGGCTCCCGGCCCCAGGGAGGCCCACCTCACTCCCAGCCTGACTCGGTGGCTGGCTTCCT
TCAGGACTTTGCGCAAGTCAGTTCTGCTCATTGGGTCTCAATTTCCCCATCCCTTGGATGGGAGCAAGAGTCTCTGCTGGGCCTGCCTCG
CAGGGGCCTGGTGAGACCCAAATGTGAGTGTCATCATCAAAGCCCCTCACAGAAGTGGAGGACGGTGCCCAAGAGTAGCGGTTTGGACTG
CTGCTGCCTCCCACCCGGAGCCTGCCACTTGGGGGAGAAATTGGTATAATGCTTGCAAAAACAAACAAACAAAAGGCAATGTCTTCTGGT
TGTGGTTATTTCCTTTCCTGCTTGCCTCCCCAGCCCCCTTTGAGTCTCTTTTTGGGGTGCCGTCCTGTCTGAACCTGCCGGTGTGTGTCT
CTGGGGCCAGGGTCAGGGCGAGGCCCAGGGGTGGACAGGGGCCGTGTAGCATGCCCCAGCCTCCCCAAGCTCCTGCTGTATGTCGTCCAT

>7258_7258_3_ASS1-NCS1_ASS1_chr9_133355836_ENST00000372394_NCS1_chr9_132963237_ENST00000372398_length(amino acids)=524AA_BP=355
MCQLPEAQSQGPSHISCLRAFLTSWPWAKLLSLSRLPSMLEDQVQEMPLPDQPRTAVSIPRPQCGLWGCVQSVRDAMSSKGSVVLAYSGG
LDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVE
IAQREGAKYVSHGATGKGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWSMDENLMHISYEAGI
LENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDGTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRVTEKE
VQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ASS1-NCS1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	NCS1	chr9:133355836	chr9:132963237	ENST00000372398		0	8	174_190	21.333333333333332	1579.3333333333333	IL1RAPL1
Tgene	NCS1	chr9:133355836	chr9:132963237	ENST00000458469		0	8	174_190	3.3333333333333335	1605.0	IL1RAPL1

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ASS1-NCS1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ASS1-NCS1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source