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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RBCK1-CLCN7 (FusionGDB2 ID:72623)

Fusion Gene Summary for RBCK1-CLCN7

check button Fusion gene summary
Fusion gene informationFusion gene name: RBCK1-CLCN7
Fusion gene ID: 72623
HgeneTgene
Gene symbol

RBCK1

CLCN7

Gene ID

10616

1186

Gene nameRANBP2-type and C3HC4-type zinc finger containing 1chloride voltage-gated channel 7
SynonymsC20orf18|HOIL-1|HOIL1|PBMEI|PGBM1|RBCK2|RNF54|UBCE7IP3|XAP3|XAP4|ZRANB4CLC-7|CLC7|HOD|OPTA2|OPTB4|PPP1R63
Cytomap

20p13

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionranBP-type and C3HC4-type zinc finger-containing protein 1HBV-associated factor 4RBCC protein interacting with PKC1RING finger protein 54RING-type E3 ubiquitin transferase HOIL-1heme-oxidized IRP2 ubiquitin ligase 1hepatitis B virus X-associated proH(+)/Cl(-) exchange transporter 7chloride channel 7 alpha subunitchloride channel protein 7chloride channel, voltage-sensitive 7protein phosphatase 1, regulatory subunit 63
Modification date2020032720200315
UniProtAcc.

P51798

Ensembl transtripts involved in fusion geneENST00000353660, ENST00000356286, 
ENST00000382181, ENST00000400245, 
ENST00000400247, ENST00000475269, 
ENST00000566812, ENST00000262318, 
ENST00000382745, ENST00000448525, 
Fusion gene scores* DoF score9 X 5 X 6=2708 X 5 X 6=240
# samples 88
** MAII scorelog2(8/270*10)=-1.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBCK1 [Title/Abstract] AND CLCN7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRBCK1(400375)-CLCN7(1509188), # samples:4
Anticipated loss of major functional domain due to fusion event.RBCK1-CLCN7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RBCK1-CLCN7 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
RBCK1-CLCN7 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRBCK1

GO:0000209

protein polyubiquitination

12629548|17006537

HgeneRBCK1

GO:0032088

negative regulation of NF-kappaB transcription factor activity

17449468

HgeneRBCK1

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

19136968|21455173

HgeneRBCK1

GO:0050852

T cell receptor signaling pathway

20005846

HgeneRBCK1

GO:0051092

positive regulation of NF-kappaB transcription factor activity

19136968

HgeneRBCK1

GO:0097039

protein linear polyubiquitination

21455173|21455180|21455181|23453807


check buttonFusion gene breakpoints across RBCK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLCN7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-5M-AAT4-01ARBCK1chr20

400375

-CLCN7chr16

1509188

-
ChimerDB4COADTCGA-5M-AAT4-01ARBCK1chr20

400375

+CLCN7chr16

1509188

-
ChimerDB4COADTCGA-AA-3979RBCK1chr20

400375

+CLCN7chr16

1509188

-


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Fusion Gene ORF analysis for RBCK1-CLCN7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000353660ENST00000566812RBCK1chr20

400375

+CLCN7chr16

1509188

-
5CDS-intronENST00000356286ENST00000566812RBCK1chr20

400375

+CLCN7chr16

1509188

-
5CDS-intronENST00000382181ENST00000566812RBCK1chr20

400375

+CLCN7chr16

1509188

-
Frame-shiftENST00000382181ENST00000262318RBCK1chr20

400375

+CLCN7chr16

1509188

-
Frame-shiftENST00000382181ENST00000382745RBCK1chr20

400375

+CLCN7chr16

1509188

-
Frame-shiftENST00000382181ENST00000448525RBCK1chr20

400375

+CLCN7chr16

1509188

-
In-frameENST00000353660ENST00000262318RBCK1chr20

400375

+CLCN7chr16

1509188

-
In-frameENST00000353660ENST00000382745RBCK1chr20

400375

+CLCN7chr16

1509188

-
In-frameENST00000353660ENST00000448525RBCK1chr20

400375

+CLCN7chr16

1509188

-
In-frameENST00000356286ENST00000262318RBCK1chr20

400375

+CLCN7chr16

1509188

-
In-frameENST00000356286ENST00000382745RBCK1chr20

400375

+CLCN7chr16

1509188

-
In-frameENST00000356286ENST00000448525RBCK1chr20

400375

+CLCN7chr16

1509188

-
intron-3CDSENST00000400245ENST00000262318RBCK1chr20

400375

+CLCN7chr16

1509188

-
intron-3CDSENST00000400245ENST00000382745RBCK1chr20

400375

+CLCN7chr16

1509188

-
intron-3CDSENST00000400245ENST00000448525RBCK1chr20

400375

+CLCN7chr16

1509188

-
intron-3CDSENST00000400247ENST00000262318RBCK1chr20

400375

+CLCN7chr16

1509188

-
intron-3CDSENST00000400247ENST00000382745RBCK1chr20

400375

+CLCN7chr16

1509188

-
intron-3CDSENST00000400247ENST00000448525RBCK1chr20

400375

+CLCN7chr16

1509188

-
intron-3CDSENST00000475269ENST00000262318RBCK1chr20

400375

+CLCN7chr16

1509188

-
intron-3CDSENST00000475269ENST00000382745RBCK1chr20

400375

+CLCN7chr16

1509188

-
intron-3CDSENST00000475269ENST00000448525RBCK1chr20

400375

+CLCN7chr16

1509188

-
intron-intronENST00000400245ENST00000566812RBCK1chr20

400375

+CLCN7chr16

1509188

-
intron-intronENST00000400247ENST00000566812RBCK1chr20

400375

+CLCN7chr16

1509188

-
intron-intronENST00000475269ENST00000566812RBCK1chr20

400375

+CLCN7chr16

1509188

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356286RBCK1chr20400375+ENST00000448525CLCN7chr161509188-498214615763284902
ENST00000356286RBCK1chr20400375+ENST00000382745CLCN7chr161509188-498114615763284902
ENST00000356286RBCK1chr20400375+ENST00000262318CLCN7chr161509188-4573146157636441022
ENST00000353660RBCK1chr20400375+ENST00000448525CLCN7chr161509188-471911985683021817
ENST00000353660RBCK1chr20400375+ENST00000382745CLCN7chr161509188-471811985683021817
ENST00000353660RBCK1chr20400375+ENST00000262318CLCN7chr161509188-431011985683381937

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356286ENST00000448525RBCK1chr20400375+CLCN7chr161509188-0.0016733710.9983266
ENST00000356286ENST00000382745RBCK1chr20400375+CLCN7chr161509188-0.001679780.99832016
ENST00000356286ENST00000262318RBCK1chr20400375+CLCN7chr161509188-0.0029678080.99703217
ENST00000353660ENST00000448525RBCK1chr20400375+CLCN7chr161509188-0.0043093940.99569064
ENST00000353660ENST00000382745RBCK1chr20400375+CLCN7chr161509188-0.0043169990.99568295
ENST00000353660ENST00000262318RBCK1chr20400375+CLCN7chr161509188-0.0044810820.9955189

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Fusion Genomic Features for RBCK1-CLCN7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RBCK1-CLCN7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:400375/chr16:1509188)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CLCN7

P51798

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRBCK1chr20:400375chr16:1509188ENST00000353660+51155_119210469.0DomainUbiquitin-like
HgeneRBCK1chr20:400375chr16:1509188ENST00000356286+61255_119252511.0DomainUbiquitin-like
HgeneRBCK1chr20:400375chr16:1509188ENST00000356286+612193_222252511.0Zinc fingerRanBP2-type
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525631_695198806.0DomainCBS 1
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525741_799198806.0DomainCBS 2
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424631_695174782.0DomainCBS 1
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424741_799174782.0DomainCBS 2
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525206_213198806.0IntramembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525288_300198806.0IntramembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525304_312198806.0IntramembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525545_559198806.0IntramembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525560_562198806.0IntramembraneNote%3DLoop between two helices
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525563_574198806.0IntramembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525575_578198806.0IntramembraneNote%3DLoop between two helices
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424206_213174782.0IntramembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424288_300174782.0IntramembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424304_312174782.0IntramembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424545_559174782.0IntramembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424560_562174782.0IntramembraneNote%3DLoop between two helices
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424563_574174782.0IntramembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424575_578174782.0IntramembraneNote%3DLoop between two helices
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525203_207198806.0MotifSelectivity filter part_1
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525245_249198806.0MotifSelectivity filter part_2
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525512_516198806.0MotifSelectivity filter part_3
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424203_207174782.0MotifSelectivity filter part_1
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424245_249174782.0MotifSelectivity filter part_2
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424512_516174782.0MotifSelectivity filter part_3
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525658_660198806.0Nucleotide bindingATP
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525783_786198806.0Nucleotide bindingATP
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424658_660174782.0Nucleotide bindingATP
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424783_786174782.0Nucleotide bindingATP
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525598_805198806.0Topological domainCytoplasmic
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424598_805174782.0Topological domainCytoplasmic
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525223_241198806.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525247_264198806.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525322_341198806.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525375_405198806.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525410_432198806.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525487_507198806.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525512_535198806.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525579_597198806.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424174_197174782.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424223_241174782.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424247_264174782.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424322_341174782.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424375_405174782.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424410_432174782.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424487_507174782.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424512_535174782.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424579_597174782.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRBCK1chr20:400375chr16:1509188ENST00000353660+511233_261210469.0Coiled coilOntology_term=ECO:0000255
HgeneRBCK1chr20:400375chr16:1509188ENST00000356286+612233_261252511.0Coiled coilOntology_term=ECO:0000255
HgeneRBCK1chr20:400375chr16:1509188ENST00000353660+511278_506210469.0RegionTRIAD supradomain
HgeneRBCK1chr20:400375chr16:1509188ENST00000356286+612278_506252511.0RegionTRIAD supradomain
HgeneRBCK1chr20:400375chr16:1509188ENST00000353660+511193_222210469.0Zinc fingerRanBP2-type
HgeneRBCK1chr20:400375chr16:1509188ENST00000353660+511282_332210469.0Zinc fingerRING-type 1
HgeneRBCK1chr20:400375chr16:1509188ENST00000353660+511351_411210469.0Zinc fingerIBR-type
HgeneRBCK1chr20:400375chr16:1509188ENST00000353660+511447_476210469.0Zinc fingerRING-type 2%3B atypical
HgeneRBCK1chr20:400375chr16:1509188ENST00000356286+612282_332252511.0Zinc fingerRING-type 1
HgeneRBCK1chr20:400375chr16:1509188ENST00000356286+612351_411252511.0Zinc fingerIBR-type
HgeneRBCK1chr20:400375chr16:1509188ENST00000356286+612447_476252511.0Zinc fingerRING-type 2%3B atypical
TgeneCLCN7chr20:400375chr16:1509188ENST000003827455251_126198806.0Topological domainCytoplasmic
TgeneCLCN7chr20:400375chr16:1509188ENST000004485254241_126174782.0Topological domainCytoplasmic
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525127_159198806.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000382745525174_197198806.0TransmembraneHelical
TgeneCLCN7chr20:400375chr16:1509188ENST00000448525424127_159174782.0TransmembraneHelical


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Fusion Gene Sequence for RBCK1-CLCN7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72623_72623_1_RBCK1-CLCN7_RBCK1_chr20_400375_ENST00000353660_CLCN7_chr16_1509188_ENST00000262318_length(transcript)=4310nt_BP=1198nt
GCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGAGGTCCCGGATGAGGCGACAATTTTTCCG
GCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAAGCCGCTCCCCTTGCGAAGAACTGGGGCC
TCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGGGGGTCCTCCGGGACTTGGAACGCCCCGG
CTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCCTGCGCCCAGTGCGGACCTGTCTCGGCGC
CCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTCCCGACTGCCGCGGGGACAGCGAGGCACA
CACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCCTCTCCCAGGCGACCCGGAGGTAGCATTT
CCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACCAAGAAAGGCTGTGGGTGAGCGTGGAGGA
TGCTCAGATGCACACCGTCACCATCTGGCTCACAGTGCGCCCTGATATGACAGTGGCGTCTCTCAAGGACATGGTTTTTCTGGACTATGG
CTTCCCACCAGTCTTGCAGCAGTGGGTGATTGGGCAGCGGCTGGCACGAGACCAGGAGACCCTGCACTCCCATGGGGTGCGGCAGAATGG
GGACAGTGCCTACCTCTATCTGCTGTCAGCCCGCAACACCTCCCTCAACCCTCAGGAGCTGCAGCGGGAGCGGCAGCTGCGGATGCTGGA
AGATCTGGGCTTCAAGGACCTCACGCTGCAGCCGCGGGGCCCTCTGGAGCCAGGCCCCCCAAAGCCCGGGGTCCCCCAGGAACCCGGACG
GGGGCAGCCAGATGCAGTGCCTGAGCCCCCACCGGTGGGCTGGCAGTGCCCCGGGTGCACCTTCATCAACAAGCCCACGCGGCCTGGCTG
TGAGATGTGCTGCCGGGCGCGCCCCGAGGCCTACCAGGTCCCCGCCTCATACCAGCCCGACGAGGAGGAGCGAGCGCGCCTGGCGGGCGA
GGAGGAGGCGCTGCGTCAGTACCAGCAGCCGGTGGCTGCTGGCAGCGGAATCCCCCAGATCAAGTGCTTCCTCAACGGGGTGAAGATCCC
CCACGTGGTGCGGCTCAAGACGTTGGTGATCAAAGTGTCCGGTGTGATCCTGTCCGTGGTCGGGGGCCTGGCCGTGGGAAAGGAAGGGCC
GATGATCCACTCAGGTTCAGTGATTGCCGCCGGGATCTCTCAGGGAAGGTCAACGTCACTGAAACGAGATTTCAAGATCTTCGAGTACTT
CCGCAGAGACACAGAGAAGCGGGACTTCGTCTCCGCAGGGGCTGCGGCCGGAGTGTCAGCGGCGTTTGGAGCCCCCGTGGGTGGGGTCCT
GTTCAGCTTGGAGGAGGGTGCGTCCTTCTGGAACCAGTTCCTGACCTGGAGGATCTTCTTTGCTTCCATGATCTCCACGTTCACCCTGAA
TTTTGTTCTGAGCATTTACCACGGGAACATGTGGGACCTGTCCAGCCCAGGCCTCATCAACTTCGGAAGGTTTGACTCGGAGAAAATGGC
CTACACGATCCACGAGATCCCGGTCTTCATCGCCATGGGCGTGGTGGGCGGTGTGCTTGGAGCAGTGTTCAATGCCTTGAACTACTGGCT
GACCATGTTTCGAATCAGGTACATCCACCGGCCCTGCCTGCAGGTGATTGAGGCCGTGCTGGTGGCCGCCGTCACGGCCACAGTTGCCTT
CGTGCTGATCTACTCGTCGCGGGATTGCCAGCCCCTGCAGGGGGGCTCCATGTCCTACCCGCTGCAGCTCTTTTGTGCAGATGGCGAGTA
CAACTCCATGGCTGCGGCCTTCTTCAACACCCCGGAGAAGAGCGTGGTGAGCCTCTTCCACGACCCGCCAGGCTCCTACAACCCCCTGAC
CCTCGGCCTGTTCACGCTGGTCTACTTCTTCCTGGCCTGCTGGACCTACGGGCTCACGGTGTCTGCCGGGGTCTTCATCCCGTCCCTGCT
CATCGGGGCTGCCTGGGGCCGGCTCTTTGGGATCTCCCTGTCCTACCTCACGGGGGCGGCGATCTGGGCGGACCCCGGCAAATACGCCCT
GATGGGAGCTGCTGCCCAGCTGGGCGGGATTGTGCGGATGACACTGAGCCTGACCGTCATCATGATGGAGGCCACCAGCAACGTGACCTA
CGGCTTCCCCATCATGCTGGTGCTCATGACCGCCAAGATCGTGGGCGACGTCTTCATTGAGGGCCTGTACGACATGCACATTCAGCTGCA
GAGTGTGCCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCACTCACTGCCAGGGAGGTGATGAGCACACCAGTGACCTGCCTGAG
GCGGCGTGAGAAGGTCGGCGTCATTGTGGACGTGCTGAGCGACACGGCGTCCAATCACAACGGCTTCCCCGTGGTGGAGCATGCCGATGA
CACCCAGCCTGCCCGGCTCCAGGGCCTGATCCTGCGCTCCCAGCTCATCGTTCTCCTAAAGCACAAGGTGTTTGTGGAGCGGTCCAACCT
GGGCCTGGTACAGCGGCGCCTGAGGCTGAAGGACTTCCGAGACGCCTACCCGCGCTTCCCACCCATCCAGTCCATCCACGTGTCCCAGGA
CGAGCGGGAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCCCCCTACACGGTGCCCCAGGCATGCGTCGCTCCCACGGGTGTTCA
AGCTGTTCCGGGCCCTGGGCCTGCGGCACCTGGTGGTGGTGGACAACCGCAATCAGGTTGTCGGGTTGGTGACCAGGAAGGACCTCGCCA
GGTACCGCCTGGGAAAGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAGACGTGAGGCCCAGCCCTGCCCATAATGGGCACTGGCGCTGGCA
CCCCGGCCCTTCTGCATTTCCTCCCGGAGTCACTGGTTTCTCGGCCCAAACCATGCTCCCCAGCAGTGGCAATGGCGAGCACCCTGCAGC
TGGGCGGGCAGGCGGCAGGCGCGGAACTGACCCTCTCGCGGGACTGACCCTGTTGTGGGCAGTGGTCTCCCCCCTTGGCGCCTCCTTGCG
CAGGCCCAGCCTCCACTCTCCTCGTCTAGGTTTCTTTACCTCCAGGGATCAGCTGTGTGTGTGTGACCTCCCTACCGGGCTATCGGCCTC
TTGGGAGCCAGCGGCAGGGCCGGCACCTGCGTGCCTGTGCCCGTGTGCGTGAGACAGAGCCCTTGCCCCTGCTGCTGCCCCGAGGGCTGC
CCTGCCCTGGAAGGGCCCCTCTGCCTCCACACCAGTGGAGTCTTCGAGACTTGGGAGCTGCTTGGCCTCATTTTCAGCCATGAGCAGACG
GCCTGTGGTCCCTGGGCCTGAGGCACGGACTCGTAGCACCAGGGTTTGGAGGCTGCGACCGCCCCGGAGAGCAGCTTCACACTGGCGCCA
CAGAGGAGCCCCACGTGCACTCCCCGGCCTGCATCCGGCTTGGGTACACAGGCCCAGAGGACTGGGGTGACTCACGGGCCCTGTGCTGTG
ATGTTGAGAGCTGAGAAAAACCTCCAAGGCCCTGAGCCCCATGCCCAGCCCTGCCTTGGTCCCCCAACCCCCAGAGCTTGGAGTCTGGGC
CCCACACCCAGCCCTGCCTTGGTCCCTGAGCCTCAGAGCGTGGAATTGCTGCCCTGTGGACACTGGCTGGGAAGGCAGGTCTTCCCCTAG
CACATGGGGACCCCGGCCTCGAGGGTGACCTCCCTACCCCGCCCCTGCCAGCCACCAAGCGCAGGTGCAGCGGGGGCCAGACTCCTGCCG
GCCTCAGAGGACACCTGGCCCAGCACAGGCAGCTAGAAGGGCCGGTGGGCACCGGGGCCGGGAAGCCCCCACCTCACCACCTGAGGGCCC
CTGGGAGGCTCCTCTGGCCTGGCTGGGCTGGGTCTGGGGCCGCCACAGGCCCCTCACGGGGCGGCAGAGGCAACTTCAGTGTCCCTGTTA
GAGCAACACGGGTCCCTCCGTGGGGGGCTGGGTGCGGCCCCCTGCCGTGTATTTCCTCCCCAGGGAGTGGGGCCTCCCCGGGAGCTGACG

>72623_72623_1_RBCK1-CLCN7_RBCK1_chr20_400375_ENST00000353660_CLCN7_chr16_1509188_ENST00000262318_length(amino acids)=937AA_BP=209
MGTATPDGREDQERLWVSVEDAQMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPVLQQWVIGQRLARDQETLHSHGVRQNGDSAYLYLLS
ARNTSLNPQELQRERQLRMLEDLGFKDLTLQPRGPLEPGPPKPGVPQEPGRGQPDAVPEPPPVGWQCPGCTFINKPTRPGCEMCCRARPE
AYQVPASYQPDEEERARLAGEEEALRQYQQPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIA
AGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGN
MWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDC
QPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLF
GISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEA
PVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRL
KDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQACVAPTGVQAVPGPGPAAPGGGGQPQSGCRVGDQEGPRQVPPGKERLG
GALAGPDVRPSPAHNGHWRWHPGPSAFPPGVTGFSAQTMLPSSGNGEHPAAGRAGGRRGTDPLAGLTLLWAVVSPLGASLRRPSLHSPRL

--------------------------------------------------------------
>72623_72623_2_RBCK1-CLCN7_RBCK1_chr20_400375_ENST00000353660_CLCN7_chr16_1509188_ENST00000382745_length(transcript)=4718nt_BP=1198nt
GCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGAGGTCCCGGATGAGGCGACAATTTTTCCG
GCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAAGCCGCTCCCCTTGCGAAGAACTGGGGCC
TCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGGGGGTCCTCCGGGACTTGGAACGCCCCGG
CTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCCTGCGCCCAGTGCGGACCTGTCTCGGCGC
CCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTCCCGACTGCCGCGGGGACAGCGAGGCACA
CACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCCTCTCCCAGGCGACCCGGAGGTAGCATTT
CCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACCAAGAAAGGCTGTGGGTGAGCGTGGAGGA
TGCTCAGATGCACACCGTCACCATCTGGCTCACAGTGCGCCCTGATATGACAGTGGCGTCTCTCAAGGACATGGTTTTTCTGGACTATGG
CTTCCCACCAGTCTTGCAGCAGTGGGTGATTGGGCAGCGGCTGGCACGAGACCAGGAGACCCTGCACTCCCATGGGGTGCGGCAGAATGG
GGACAGTGCCTACCTCTATCTGCTGTCAGCCCGCAACACCTCCCTCAACCCTCAGGAGCTGCAGCGGGAGCGGCAGCTGCGGATGCTGGA
AGATCTGGGCTTCAAGGACCTCACGCTGCAGCCGCGGGGCCCTCTGGAGCCAGGCCCCCCAAAGCCCGGGGTCCCCCAGGAACCCGGACG
GGGGCAGCCAGATGCAGTGCCTGAGCCCCCACCGGTGGGCTGGCAGTGCCCCGGGTGCACCTTCATCAACAAGCCCACGCGGCCTGGCTG
TGAGATGTGCTGCCGGGCGCGCCCCGAGGCCTACCAGGTCCCCGCCTCATACCAGCCCGACGAGGAGGAGCGAGCGCGCCTGGCGGGCGA
GGAGGAGGCGCTGCGTCAGTACCAGCAGCCGGTGGCTGCTGGCAGCGGAATCCCCCAGATCAAGTGCTTCCTCAACGGGGTGAAGATCCC
CCACGTGGTGCGGCTCAAGACGTTGGTGATCAAAGTGTCCGGTGTGATCCTGTCCGTGGTCGGGGGCCTGGCCGTGGGAAAGGAAGGGCC
GATGATCCACTCAGGTTCAGTGATTGCCGCCGGGATCTCTCAGGGAAGGTCAACGTCACTGAAACGAGATTTCAAGATCTTCGAGTACTT
CCGCAGAGACACAGAGAAGCGGGACTTCGTCTCCGCAGGGGCTGCGGCCGGAGTGTCAGCGGCGTTTGGAGCCCCCGTGGGTGGGGTCCT
GTTCAGCTTGGAGGAGGGTGCGTCCTTCTGGAACCAGTTCCTGACCTGGAGGATCTTCTTTGCTTCCATGATCTCCACGTTCACCCTGAA
TTTTGTTCTGAGCATTTACCACGGGAACATGTGGGACCTGTCCAGCCCAGGCCTCATCAACTTCGGAAGGTTTGACTCGGAGAAAATGGC
CTACACGATCCACGAGATCCCGGTCTTCATCGCCATGGGCGTGGTGGGCGGTGTGCTTGGAGCAGTGTTCAATGCCTTGAACTACTGGCT
GACCATGTTTCGAATCAGGTACATCCACCGGCCCTGCCTGCAGGTGATTGAGGCCGTGCTGGTGGCCGCCGTCACGGCCACAGTTGCCTT
CGTGCTGATCTACTCGTCGCGGGATTGCCAGCCCCTGCAGGGGGGCTCCATGTCCTACCCGCTGCAGCTCTTTTGTGCAGATGGCGAGTA
CAACTCCATGGCTGCGGCCTTCTTCAACACCCCGGAGAAGAGCGTGGTGAGCCTCTTCCACGACCCGCCAGGCTCCTACAACCCCCTGAC
CCTCGGCCTGTTCACGCTGGTCTACTTCTTCCTGGCCTGCTGGACCTACGGGCTCACGGTGTCTGCCGGGGTCTTCATCCCGTCCCTGCT
CATCGGGGCTGCCTGGGGCCGGCTCTTTGGGATCTCCCTGTCCTACCTCACGGGGGCGGCGATCTGGGCGGACCCCGGCAAATACGCCCT
GATGGGAGCTGCTGCCCAGCTGGGCGGGATTGTGCGGATGACACTGAGCCTGACCGTCATCATGATGGAGGCCACCAGCAACGTGACCTA
CGGCTTCCCCATCATGCTGGTGCTCATGACCGCCAAGATCGTGGGCGACGTCTTCATTGAGGGCCTGTACGACATGCACATTCAGCTGCA
GAGTGTGCCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCACTCACTGCCAGGGAGGTGATGAGCACACCAGTGACCTGCCTGAG
GCGGCGTGAGAAGGTCGGCGTCATTGTGGACGTGCTGAGCGACACGGCGTCCAATCACAACGGCTTCCCCGTGGTGGAGCATGCCGATGA
CACCCAGCCTGCCCGGCTCCAGGGCCTGATCCTGCGCTCCCAGCTCATCGTTCTCCTAAAGCACAAGGTGTTTGTGGAGCGGTCCAACCT
GGGCCTGGTACAGCGGCGCCTGAGGCTGAAGGACTTCCGAGACGCCTACCCGCGCTTCCCACCCATCCAGTCCATCCACGTGTCCCAGGA
CGAGCGGGAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCCCCCTACACGGTGCCCCAGGAGGCGTCGCTCCCACGGGTGTTCAA
GCTGTTCCGGGCCCTGGGCCTGCGGCACCTGGTGGTGGTGGACAACCGCAATCAGGTTGTCGGGTTGGTGACCAGGAAGGACCTCGCCAG
GTACCGCCTGGGAAAGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAGACGTGAGGCCCAGCCCTGCCCATAATGGGCACTGGCGCTGGCAC
CCCGGCCCTTCTGCATTTCCTCCCGGAGTCACTGGTTTCTCGGCCCAAACCATGCTCCCCAGCAGTGGCAATGGCGAGCACCCTGCAGCT
GGGCGGGCAGGCGGCAGGCGCGGAACTGACCCTCTCGCGGGACTGACCCTGTTGTGGGCAGTGGTCTCCCCCCTTGGCGCCTCCTTGCGC
AGGCCCAGCCTCCACTCTCCTCGTCTAGGTTTCTTTACCTCCAGGGATCAGCTGTGTGTGTGTGACCTCCCTACCGGGCTATCGGCCTCT
TGGGAGCCAGCGGCAGGGCCGGCACCTGCGTGCCTGTGCCCGTGTGCGTGAGACAGAGCCCTTGCCCCTGCTGCTGCCCCGAGGGCTGCC
CTGCCCTGGAAGGGCCCCTCTGCCTCCACACCAGTGGAGTCTTCGAGACTTGGGAGCTGCTTGGCCTCATTTTCAGCCATGAGCAGACGG
CCTGTGGTCCCTGGGCCTGAGGCACGGACTCGTAGCACCAGGGTTTGGAGGCTGCGACCGCCCCGGAGAGCAGCTTCACACTGGCGCCAC
AGAGGAGCCCCACGTGCACTCCCCGGCCTGCATCCGGCTTGGGTACACAGGCCCAGAGGACTGGGGTGACTCACGGGCCCTGTGCTGTGA
TGTTGAGAGCTGAGAAAAACCTCCAAGGCCCTGAGCCCCATGCCCAGCCCTGCCTTGGTCCCCCAACCCCCAGAGCTTGGAGTCTGGGCC
CCACACCCAGCCCTGCCTTGGTCCCTGAGCCTCAGAGCGTGGAATTGCTGCCCTGTGGACACTGGCTGGGAAGGCAGGTCTTCCCCTAGC
ACATGGGGACCCCGGCCTCGAGGGTGACCTCCCTACCCCGCCCCTGCCAGCCACCAAGCGCAGGTGCAGCGGGGGCCAGACTCCTGCCGG
CCTCAGAGGACACCTGGCCCAGCACAGGCAGCTAGAAGGGCCGGTGGGCACCGGGGCCGGGAAGCCCCCACCTCACCACCTGAGGGCCCC
TGGGAGGCTCCTCTGGCCTGGCTGGGCTGGGTCTGGGGCCGCCACAGGCCCCTCACGGGGCGGCAGAGGCAACTTCAGTGTCCCTGTTAG
AGCAACACGGGTCCCTCCGTGGGGGGCTGGGTGCGGCCCCCTGCCGTGTATTTCCTCCCCAGGGAGTGGGGCCTCCCCGGGAGCTGACGC
CACCACCCTGCTTAGCCCTCACAGGGCCCCAAGGTGTCCGAGTGTGTTGGGTCTGAACGCGAAATAAAGAAATCCTCTCAGCCCGCCTTT
GCCAGCGTCGTCCCTCCCACCCCACCCAGACCACGTCCAACAGCCTGGGACTTTCGGGACCCTGGGGTCGGGGCACCGTGTGGAGTGAGA
AAGGCGTGAAAGACAGCGGCTGCGGCCACCCAGGGCACCAGCCACATCCTCTTCCTCGTCCCCGCCCCTCAGCCTCCCTCCTCTGGCTCC
TGGCTGGTGGGTCTGGGGGCAAGGCAGAGGCGCTCCAGGTGGAGGGGGGCGGGCCGGGGTGCCCACGCTGGGGTGACGCAAGAAGAAAAC
TCCCGGGCCTCAGAGTCGGCGCCGGAAACCTAGGTCTGGGTTTCCCTCGTGGTGGTTGTGTACTGAGGACCTGGAAGTGATCATATTTTG

>72623_72623_2_RBCK1-CLCN7_RBCK1_chr20_400375_ENST00000353660_CLCN7_chr16_1509188_ENST00000382745_length(amino acids)=817AA_BP=209
MGTATPDGREDQERLWVSVEDAQMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPVLQQWVIGQRLARDQETLHSHGVRQNGDSAYLYLLS
ARNTSLNPQELQRERQLRMLEDLGFKDLTLQPRGPLEPGPPKPGVPQEPGRGQPDAVPEPPPVGWQCPGCTFINKPTRPGCEMCCRARPE
AYQVPASYQPDEEERARLAGEEEALRQYQQPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIA
AGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGN
MWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDC
QPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLF
GISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEA
PVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRL
KDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLE

--------------------------------------------------------------
>72623_72623_3_RBCK1-CLCN7_RBCK1_chr20_400375_ENST00000353660_CLCN7_chr16_1509188_ENST00000448525_length(transcript)=4719nt_BP=1198nt
GCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGAGGTCCCGGATGAGGCGACAATTTTTCCG
GCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAAGCCGCTCCCCTTGCGAAGAACTGGGGCC
TCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGGGGGTCCTCCGGGACTTGGAACGCCCCGG
CTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCCTGCGCCCAGTGCGGACCTGTCTCGGCGC
CCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTCCCGACTGCCGCGGGGACAGCGAGGCACA
CACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCCTCTCCCAGGCGACCCGGAGGTAGCATTT
CCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACCAAGAAAGGCTGTGGGTGAGCGTGGAGGA
TGCTCAGATGCACACCGTCACCATCTGGCTCACAGTGCGCCCTGATATGACAGTGGCGTCTCTCAAGGACATGGTTTTTCTGGACTATGG
CTTCCCACCAGTCTTGCAGCAGTGGGTGATTGGGCAGCGGCTGGCACGAGACCAGGAGACCCTGCACTCCCATGGGGTGCGGCAGAATGG
GGACAGTGCCTACCTCTATCTGCTGTCAGCCCGCAACACCTCCCTCAACCCTCAGGAGCTGCAGCGGGAGCGGCAGCTGCGGATGCTGGA
AGATCTGGGCTTCAAGGACCTCACGCTGCAGCCGCGGGGCCCTCTGGAGCCAGGCCCCCCAAAGCCCGGGGTCCCCCAGGAACCCGGACG
GGGGCAGCCAGATGCAGTGCCTGAGCCCCCACCGGTGGGCTGGCAGTGCCCCGGGTGCACCTTCATCAACAAGCCCACGCGGCCTGGCTG
TGAGATGTGCTGCCGGGCGCGCCCCGAGGCCTACCAGGTCCCCGCCTCATACCAGCCCGACGAGGAGGAGCGAGCGCGCCTGGCGGGCGA
GGAGGAGGCGCTGCGTCAGTACCAGCAGCCGGTGGCTGCTGGCAGCGGAATCCCCCAGATCAAGTGCTTCCTCAACGGGGTGAAGATCCC
CCACGTGGTGCGGCTCAAGACGTTGGTGATCAAAGTGTCCGGTGTGATCCTGTCCGTGGTCGGGGGCCTGGCCGTGGGAAAGGAAGGGCC
GATGATCCACTCAGGTTCAGTGATTGCCGCCGGGATCTCTCAGGGAAGGTCAACGTCACTGAAACGAGATTTCAAGATCTTCGAGTACTT
CCGCAGAGACACAGAGAAGCGGGACTTCGTCTCCGCAGGGGCTGCGGCCGGAGTGTCAGCGGCGTTTGGAGCCCCCGTGGGTGGGGTCCT
GTTCAGCTTGGAGGAGGGTGCGTCCTTCTGGAACCAGTTCCTGACCTGGAGGATCTTCTTTGCTTCCATGATCTCCACGTTCACCCTGAA
TTTTGTTCTGAGCATTTACCACGGGAACATGTGGGACCTGTCCAGCCCAGGCCTCATCAACTTCGGAAGGTTTGACTCGGAGAAAATGGC
CTACACGATCCACGAGATCCCGGTCTTCATCGCCATGGGCGTGGTGGGCGGTGTGCTTGGAGCAGTGTTCAATGCCTTGAACTACTGGCT
GACCATGTTTCGAATCAGGTACATCCACCGGCCCTGCCTGCAGGTGATTGAGGCCGTGCTGGTGGCCGCCGTCACGGCCACAGTTGCCTT
CGTGCTGATCTACTCGTCGCGGGATTGCCAGCCCCTGCAGGGGGGCTCCATGTCCTACCCGCTGCAGCTCTTTTGTGCAGATGGCGAGTA
CAACTCCATGGCTGCGGCCTTCTTCAACACCCCGGAGAAGAGCGTGGTGAGCCTCTTCCACGACCCGCCAGGCTCCTACAACCCCCTGAC
CCTCGGCCTGTTCACGCTGGTCTACTTCTTCCTGGCCTGCTGGACCTACGGGCTCACGGTGTCTGCCGGGGTCTTCATCCCGTCCCTGCT
CATCGGGGCTGCCTGGGGCCGGCTCTTTGGGATCTCCCTGTCCTACCTCACGGGGGCGGCGATCTGGGCGGACCCCGGCAAATACGCCCT
GATGGGAGCTGCTGCCCAGCTGGGCGGGATTGTGCGGATGACACTGAGCCTGACCGTCATCATGATGGAGGCCACCAGCAACGTGACCTA
CGGCTTCCCCATCATGCTGGTGCTCATGACCGCCAAGATCGTGGGCGACGTCTTCATTGAGGGCCTGTACGACATGCACATTCAGCTGCA
GAGTGTGCCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCACTCACTGCCAGGGAGGTGATGAGCACACCAGTGACCTGCCTGAG
GCGGCGTGAGAAGGTCGGCGTCATTGTGGACGTGCTGAGCGACACGGCGTCCAATCACAACGGCTTCCCCGTGGTGGAGCATGCCGATGA
CACCCAGCCTGCCCGGCTCCAGGGCCTGATCCTGCGCTCCCAGCTCATCGTTCTCCTAAAGCACAAGGTGTTTGTGGAGCGGTCCAACCT
GGGCCTGGTACAGCGGCGCCTGAGGCTGAAGGACTTCCGAGACGCCTACCCGCGCTTCCCACCCATCCAGTCCATCCACGTGTCCCAGGA
CGAGCGGGAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCCCCCTACACGGTGCCCCAGGAGGCGTCGCTCCCACGGGTGTTCAA
GCTGTTCCGGGCCCTGGGCCTGCGGCACCTGGTGGTGGTGGACAACCGCAATCAGGTTGTCGGGTTGGTGACCAGGAAGGACCTCGCCAG
GTACCGCCTGGGAAAGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAGACGTGAGGCCCAGCCCTGCCCATAATGGGCACTGGCGCTGGCAC
CCCGGCCCTTCTGCATTTCCTCCCGGAGTCACTGGTTTCTCGGCCCAAACCATGCTCCCCAGCAGTGGCAATGGCGAGCACCCTGCAGCT
GGGCGGGCAGGCGGCAGGCGCGGAACTGACCCTCTCGCGGGACTGACCCTGTTGTGGGCAGTGGTCTCCCCCCTTGGCGCCTCCTTGCGC
AGGCCCAGCCTCCACTCTCCTCGTCTAGGTTTCTTTACCTCCAGGGATCAGCTGTGTGTGTGTGACCTCCCTACCGGGCTATCGGCCTCT
TGGGAGCCAGCGGCAGGGCCGGCACCTGCGTGCCTGTGCCCGTGTGCGTGAGACAGAGCCCTTGCCCCTGCTGCTGCCCCGAGGGCTGCC
CTGCCCTGGAAGGGCCCCTCTGCCTCCACACCAGTGGAGTCTTCGAGACTTGGGAGCTGCTTGGCCTCATTTTCAGCCATGAGCAGACGG
CCTGTGGTCCCTGGGCCTGAGGCACGGACTCGTAGCACCAGGGTTTGGAGGCTGCGACCGCCCCGGAGAGCAGCTTCACACTGGCGCCAC
AGAGGAGCCCCACGTGCACTCCCCGGCCTGCATCCGGCTTGGGTACACAGGCCCAGAGGACTGGGGTGACTCACGGGCCCTGTGCTGTGA
TGTTGAGAGCTGAGAAAAACCTCCAAGGCCCTGAGCCCCATGCCCAGCCCTGCCTTGGTCCCCCAACCCCCAGAGCTTGGAGTCTGGGCC
CCACACCCAGCCCTGCCTTGGTCCCTGAGCCTCAGAGCGTGGAATTGCTGCCCTGTGGACACTGGCTGGGAAGGCAGGTCTTCCCCTAGC
ACATGGGGACCCCGGCCTCGAGGGTGACCTCCCTACCCCGCCCCTGCCAGCCACCAAGCGCAGGTGCAGCGGGGGCCAGACTCCTGCCGG
CCTCAGAGGACACCTGGCCCAGCACAGGCAGCTAGAAGGGCCGGTGGGCACCGGGGCCGGGAAGCCCCCACCTCACCACCTGAGGGCCCC
TGGGAGGCTCCTCTGGCCTGGCTGGGCTGGGTCTGGGGCCGCCACAGGCCCCTCACGGGGCGGCAGAGGCAACTTCAGTGTCCCTGTTAG
AGCAACACGGGTCCCTCCGTGGGGGGCTGGGTGCGGCCCCCTGCCGTGTATTTCCTCCCCAGGGAGTGGGGCCTCCCCGGGAGCTGACGC
CACCACCCTGCTTAGCCCTCACAGGGCCCCAAGGTGTCCGAGTGTGTTGGGTCTGAACGCGAAATAAAGAAATCCTCTCAGCCCGCCTTT
GCCAGCGTCGTCCCTCCCACCCCACCCAGACCACGTCCAACAGCCTGGGACTTTCGGGACCCTGGGGTCGGGGCACCGTGTGGAGTGAGA
AAGGCGTGAAAGACAGCGGCTGCGGCCACCCAGGGCACCAGCCACATCCTCTTCCTCGTCCCCGCCCCTCAGCCTCCCTCCTCTGGCTCC
TGGCTGGTGGGTCTGGGGGCAAGGCAGAGGCGCTCCAGGTGGAGGGGGGCGGGCCGGGGTGCCCACGCTGGGGTGACGCAAGAAGAAAAC
TCCCGGGCCTCAGAGTCGGCGCCGGAAACCTAGGTCTGGGTTTCCCTCGTGGTGGTTGTGTACTGAGGACCTGGAAGTGATCATATTTTG

>72623_72623_3_RBCK1-CLCN7_RBCK1_chr20_400375_ENST00000353660_CLCN7_chr16_1509188_ENST00000448525_length(amino acids)=817AA_BP=209
MGTATPDGREDQERLWVSVEDAQMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPVLQQWVIGQRLARDQETLHSHGVRQNGDSAYLYLLS
ARNTSLNPQELQRERQLRMLEDLGFKDLTLQPRGPLEPGPPKPGVPQEPGRGQPDAVPEPPPVGWQCPGCTFINKPTRPGCEMCCRARPE
AYQVPASYQPDEEERARLAGEEEALRQYQQPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIA
AGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGN
MWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDC
QPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLF
GISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEA
PVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRL
KDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLE

--------------------------------------------------------------
>72623_72623_4_RBCK1-CLCN7_RBCK1_chr20_400375_ENST00000356286_CLCN7_chr16_1509188_ENST00000262318_length(transcript)=4573nt_BP=1461nt
CGCCTGCGGCCCAGCTCCTTCCCGCGGCTCTGCGATGCGGCCCGCAGGGTGACCCGGGCGGGAGTCCGGGGACCCGCGATCAGCCCCGGA
GGACGGGGTGGGGTCGCCCCAAACAGGAGCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGA
GGTCCCGGATGAGGCGACAATTTTTCCGGCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAA
GCCGCTCCCCTTGCGAAGAACTGGGGCCTCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGG
GGGTCCTCCGGGACTTGGAACGCCCCGGCTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCC
TGCGCCCAGTGCGGACCTGTCTCGGCGCCCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTC
CCGACTGCCGCGGGGACAGCGAGGCACACACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCC
TCTCCCAGGCGACCCGGAGGTAGCATTTCCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACC
AAGAAAGCAGAGGAAATGGCCCTGAGCCTCACCCGAGCAGTGGCGGGCGGGGATGAACAGGTGGCAATGAAGTGTGCCATCTGGCTGGCA
GAGCAACGGGTGCCCCTGAGTGTGCAACTGAAGCCTGAGGTCTCCCCAACGCAGGACATCAGGCTGTGGGTGAGCGTGGAGGATGCTCAG
ATGCACACCGTCACCATCTGGCTCACAGTGCGCCCTGATATGACAGTGGCGTCTCTCAAGGACATGGTTTTTCTGGACTATGGCTTCCCA
CCAGTCTTGCAGCAGTGGGTGATTGGGCAGCGGCTGGCACGAGACCAGGAGACCCTGCACTCCCATGGGGTGCGGCAGAATGGGGACAGT
GCCTACCTCTATCTGCTGTCAGCCCGCAACACCTCCCTCAACCCTCAGGAGCTGCAGCGGGAGCGGCAGCTGCGGATGCTGGAAGATCTG
GGCTTCAAGGACCTCACGCTGCAGCCGCGGGGCCCTCTGGAGCCAGGCCCCCCAAAGCCCGGGGTCCCCCAGGAACCCGGACGGGGGCAG
CCAGATGCAGTGCCTGAGCCCCCACCGGTGGGCTGGCAGTGCCCCGGGTGCACCTTCATCAACAAGCCCACGCGGCCTGGCTGTGAGATG
TGCTGCCGGGCGCGCCCCGAGGCCTACCAGGTCCCCGCCTCATACCAGCCCGACGAGGAGGAGCGAGCGCGCCTGGCGGGCGAGGAGGAG
GCGCTGCGTCAGTACCAGCAGCCGGTGGCTGCTGGCAGCGGAATCCCCCAGATCAAGTGCTTCCTCAACGGGGTGAAGATCCCCCACGTG
GTGCGGCTCAAGACGTTGGTGATCAAAGTGTCCGGTGTGATCCTGTCCGTGGTCGGGGGCCTGGCCGTGGGAAAGGAAGGGCCGATGATC
CACTCAGGTTCAGTGATTGCCGCCGGGATCTCTCAGGGAAGGTCAACGTCACTGAAACGAGATTTCAAGATCTTCGAGTACTTCCGCAGA
GACACAGAGAAGCGGGACTTCGTCTCCGCAGGGGCTGCGGCCGGAGTGTCAGCGGCGTTTGGAGCCCCCGTGGGTGGGGTCCTGTTCAGC
TTGGAGGAGGGTGCGTCCTTCTGGAACCAGTTCCTGACCTGGAGGATCTTCTTTGCTTCCATGATCTCCACGTTCACCCTGAATTTTGTT
CTGAGCATTTACCACGGGAACATGTGGGACCTGTCCAGCCCAGGCCTCATCAACTTCGGAAGGTTTGACTCGGAGAAAATGGCCTACACG
ATCCACGAGATCCCGGTCTTCATCGCCATGGGCGTGGTGGGCGGTGTGCTTGGAGCAGTGTTCAATGCCTTGAACTACTGGCTGACCATG
TTTCGAATCAGGTACATCCACCGGCCCTGCCTGCAGGTGATTGAGGCCGTGCTGGTGGCCGCCGTCACGGCCACAGTTGCCTTCGTGCTG
ATCTACTCGTCGCGGGATTGCCAGCCCCTGCAGGGGGGCTCCATGTCCTACCCGCTGCAGCTCTTTTGTGCAGATGGCGAGTACAACTCC
ATGGCTGCGGCCTTCTTCAACACCCCGGAGAAGAGCGTGGTGAGCCTCTTCCACGACCCGCCAGGCTCCTACAACCCCCTGACCCTCGGC
CTGTTCACGCTGGTCTACTTCTTCCTGGCCTGCTGGACCTACGGGCTCACGGTGTCTGCCGGGGTCTTCATCCCGTCCCTGCTCATCGGG
GCTGCCTGGGGCCGGCTCTTTGGGATCTCCCTGTCCTACCTCACGGGGGCGGCGATCTGGGCGGACCCCGGCAAATACGCCCTGATGGGA
GCTGCTGCCCAGCTGGGCGGGATTGTGCGGATGACACTGAGCCTGACCGTCATCATGATGGAGGCCACCAGCAACGTGACCTACGGCTTC
CCCATCATGCTGGTGCTCATGACCGCCAAGATCGTGGGCGACGTCTTCATTGAGGGCCTGTACGACATGCACATTCAGCTGCAGAGTGTG
CCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCACTCACTGCCAGGGAGGTGATGAGCACACCAGTGACCTGCCTGAGGCGGCGT
GAGAAGGTCGGCGTCATTGTGGACGTGCTGAGCGACACGGCGTCCAATCACAACGGCTTCCCCGTGGTGGAGCATGCCGATGACACCCAG
CCTGCCCGGCTCCAGGGCCTGATCCTGCGCTCCCAGCTCATCGTTCTCCTAAAGCACAAGGTGTTTGTGGAGCGGTCCAACCTGGGCCTG
GTACAGCGGCGCCTGAGGCTGAAGGACTTCCGAGACGCCTACCCGCGCTTCCCACCCATCCAGTCCATCCACGTGTCCCAGGACGAGCGG
GAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCCCCCTACACGGTGCCCCAGGCATGCGTCGCTCCCACGGGTGTTCAAGCTGTT
CCGGGCCCTGGGCCTGCGGCACCTGGTGGTGGTGGACAACCGCAATCAGGTTGTCGGGTTGGTGACCAGGAAGGACCTCGCCAGGTACCG
CCTGGGAAAGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAGACGTGAGGCCCAGCCCTGCCCATAATGGGCACTGGCGCTGGCACCCCGGC
CCTTCTGCATTTCCTCCCGGAGTCACTGGTTTCTCGGCCCAAACCATGCTCCCCAGCAGTGGCAATGGCGAGCACCCTGCAGCTGGGCGG
GCAGGCGGCAGGCGCGGAACTGACCCTCTCGCGGGACTGACCCTGTTGTGGGCAGTGGTCTCCCCCCTTGGCGCCTCCTTGCGCAGGCCC
AGCCTCCACTCTCCTCGTCTAGGTTTCTTTACCTCCAGGGATCAGCTGTGTGTGTGTGACCTCCCTACCGGGCTATCGGCCTCTTGGGAG
CCAGCGGCAGGGCCGGCACCTGCGTGCCTGTGCCCGTGTGCGTGAGACAGAGCCCTTGCCCCTGCTGCTGCCCCGAGGGCTGCCCTGCCC
TGGAAGGGCCCCTCTGCCTCCACACCAGTGGAGTCTTCGAGACTTGGGAGCTGCTTGGCCTCATTTTCAGCCATGAGCAGACGGCCTGTG
GTCCCTGGGCCTGAGGCACGGACTCGTAGCACCAGGGTTTGGAGGCTGCGACCGCCCCGGAGAGCAGCTTCACACTGGCGCCACAGAGGA
GCCCCACGTGCACTCCCCGGCCTGCATCCGGCTTGGGTACACAGGCCCAGAGGACTGGGGTGACTCACGGGCCCTGTGCTGTGATGTTGA
GAGCTGAGAAAAACCTCCAAGGCCCTGAGCCCCATGCCCAGCCCTGCCTTGGTCCCCCAACCCCCAGAGCTTGGAGTCTGGGCCCCACAC
CCAGCCCTGCCTTGGTCCCTGAGCCTCAGAGCGTGGAATTGCTGCCCTGTGGACACTGGCTGGGAAGGCAGGTCTTCCCCTAGCACATGG
GGACCCCGGCCTCGAGGGTGACCTCCCTACCCCGCCCCTGCCAGCCACCAAGCGCAGGTGCAGCGGGGGCCAGACTCCTGCCGGCCTCAG
AGGACACCTGGCCCAGCACAGGCAGCTAGAAGGGCCGGTGGGCACCGGGGCCGGGAAGCCCCCACCTCACCACCTGAGGGCCCCTGGGAG
GCTCCTCTGGCCTGGCTGGGCTGGGTCTGGGGCCGCCACAGGCCCCTCACGGGGCGGCAGAGGCAACTTCAGTGTCCCTGTTAGAGCAAC
ACGGGTCCCTCCGTGGGGGGCTGGGTGCGGCCCCCTGCCGTGTATTTCCTCCCCAGGGAGTGGGGCCTCCCCGGGAGCTGACGCCACCAC

>72623_72623_4_RBCK1-CLCN7_RBCK1_chr20_400375_ENST00000356286_CLCN7_chr16_1509188_ENST00000262318_length(amino acids)=1022AA_BP=294
MGRAGGHTAWLSCSWSPASPRRPGGSISQEARSPPGGWAQPRQMDEKTKKAEEMALSLTRAVAGGDEQVAMKCAIWLAEQRVPLSVQLKP
EVSPTQDIRLWVSVEDAQMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPVLQQWVIGQRLARDQETLHSHGVRQNGDSAYLYLLSARNTS
LNPQELQRERQLRMLEDLGFKDLTLQPRGPLEPGPPKPGVPQEPGRGQPDAVPEPPPVGWQCPGCTFINKPTRPGCEMCCRARPEAYQVP
ASYQPDEEERARLAGEEEALRQYQQPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQ
GRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLS
SPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQG
GSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLS
YLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSH
SLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRD
AYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQACVAPTGVQAVPGPGPAAPGGGGQPQSGCRVGDQEGPRQVPPGKERLGGALAG
PDVRPSPAHNGHWRWHPGPSAFPPGVTGFSAQTMLPSSGNGEHPAAGRAGGRRGTDPLAGLTLLWAVVSPLGASLRRPSLHSPRLGFFTS

--------------------------------------------------------------
>72623_72623_5_RBCK1-CLCN7_RBCK1_chr20_400375_ENST00000356286_CLCN7_chr16_1509188_ENST00000382745_length(transcript)=4981nt_BP=1461nt
CGCCTGCGGCCCAGCTCCTTCCCGCGGCTCTGCGATGCGGCCCGCAGGGTGACCCGGGCGGGAGTCCGGGGACCCGCGATCAGCCCCGGA
GGACGGGGTGGGGTCGCCCCAAACAGGAGCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGA
GGTCCCGGATGAGGCGACAATTTTTCCGGCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAA
GCCGCTCCCCTTGCGAAGAACTGGGGCCTCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGG
GGGTCCTCCGGGACTTGGAACGCCCCGGCTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCC
TGCGCCCAGTGCGGACCTGTCTCGGCGCCCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTC
CCGACTGCCGCGGGGACAGCGAGGCACACACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCC
TCTCCCAGGCGACCCGGAGGTAGCATTTCCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACC
AAGAAAGCAGAGGAAATGGCCCTGAGCCTCACCCGAGCAGTGGCGGGCGGGGATGAACAGGTGGCAATGAAGTGTGCCATCTGGCTGGCA
GAGCAACGGGTGCCCCTGAGTGTGCAACTGAAGCCTGAGGTCTCCCCAACGCAGGACATCAGGCTGTGGGTGAGCGTGGAGGATGCTCAG
ATGCACACCGTCACCATCTGGCTCACAGTGCGCCCTGATATGACAGTGGCGTCTCTCAAGGACATGGTTTTTCTGGACTATGGCTTCCCA
CCAGTCTTGCAGCAGTGGGTGATTGGGCAGCGGCTGGCACGAGACCAGGAGACCCTGCACTCCCATGGGGTGCGGCAGAATGGGGACAGT
GCCTACCTCTATCTGCTGTCAGCCCGCAACACCTCCCTCAACCCTCAGGAGCTGCAGCGGGAGCGGCAGCTGCGGATGCTGGAAGATCTG
GGCTTCAAGGACCTCACGCTGCAGCCGCGGGGCCCTCTGGAGCCAGGCCCCCCAAAGCCCGGGGTCCCCCAGGAACCCGGACGGGGGCAG
CCAGATGCAGTGCCTGAGCCCCCACCGGTGGGCTGGCAGTGCCCCGGGTGCACCTTCATCAACAAGCCCACGCGGCCTGGCTGTGAGATG
TGCTGCCGGGCGCGCCCCGAGGCCTACCAGGTCCCCGCCTCATACCAGCCCGACGAGGAGGAGCGAGCGCGCCTGGCGGGCGAGGAGGAG
GCGCTGCGTCAGTACCAGCAGCCGGTGGCTGCTGGCAGCGGAATCCCCCAGATCAAGTGCTTCCTCAACGGGGTGAAGATCCCCCACGTG
GTGCGGCTCAAGACGTTGGTGATCAAAGTGTCCGGTGTGATCCTGTCCGTGGTCGGGGGCCTGGCCGTGGGAAAGGAAGGGCCGATGATC
CACTCAGGTTCAGTGATTGCCGCCGGGATCTCTCAGGGAAGGTCAACGTCACTGAAACGAGATTTCAAGATCTTCGAGTACTTCCGCAGA
GACACAGAGAAGCGGGACTTCGTCTCCGCAGGGGCTGCGGCCGGAGTGTCAGCGGCGTTTGGAGCCCCCGTGGGTGGGGTCCTGTTCAGC
TTGGAGGAGGGTGCGTCCTTCTGGAACCAGTTCCTGACCTGGAGGATCTTCTTTGCTTCCATGATCTCCACGTTCACCCTGAATTTTGTT
CTGAGCATTTACCACGGGAACATGTGGGACCTGTCCAGCCCAGGCCTCATCAACTTCGGAAGGTTTGACTCGGAGAAAATGGCCTACACG
ATCCACGAGATCCCGGTCTTCATCGCCATGGGCGTGGTGGGCGGTGTGCTTGGAGCAGTGTTCAATGCCTTGAACTACTGGCTGACCATG
TTTCGAATCAGGTACATCCACCGGCCCTGCCTGCAGGTGATTGAGGCCGTGCTGGTGGCCGCCGTCACGGCCACAGTTGCCTTCGTGCTG
ATCTACTCGTCGCGGGATTGCCAGCCCCTGCAGGGGGGCTCCATGTCCTACCCGCTGCAGCTCTTTTGTGCAGATGGCGAGTACAACTCC
ATGGCTGCGGCCTTCTTCAACACCCCGGAGAAGAGCGTGGTGAGCCTCTTCCACGACCCGCCAGGCTCCTACAACCCCCTGACCCTCGGC
CTGTTCACGCTGGTCTACTTCTTCCTGGCCTGCTGGACCTACGGGCTCACGGTGTCTGCCGGGGTCTTCATCCCGTCCCTGCTCATCGGG
GCTGCCTGGGGCCGGCTCTTTGGGATCTCCCTGTCCTACCTCACGGGGGCGGCGATCTGGGCGGACCCCGGCAAATACGCCCTGATGGGA
GCTGCTGCCCAGCTGGGCGGGATTGTGCGGATGACACTGAGCCTGACCGTCATCATGATGGAGGCCACCAGCAACGTGACCTACGGCTTC
CCCATCATGCTGGTGCTCATGACCGCCAAGATCGTGGGCGACGTCTTCATTGAGGGCCTGTACGACATGCACATTCAGCTGCAGAGTGTG
CCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCACTCACTGCCAGGGAGGTGATGAGCACACCAGTGACCTGCCTGAGGCGGCGT
GAGAAGGTCGGCGTCATTGTGGACGTGCTGAGCGACACGGCGTCCAATCACAACGGCTTCCCCGTGGTGGAGCATGCCGATGACACCCAG
CCTGCCCGGCTCCAGGGCCTGATCCTGCGCTCCCAGCTCATCGTTCTCCTAAAGCACAAGGTGTTTGTGGAGCGGTCCAACCTGGGCCTG
GTACAGCGGCGCCTGAGGCTGAAGGACTTCCGAGACGCCTACCCGCGCTTCCCACCCATCCAGTCCATCCACGTGTCCCAGGACGAGCGG
GAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCCCCCTACACGGTGCCCCAGGAGGCGTCGCTCCCACGGGTGTTCAAGCTGTTC
CGGGCCCTGGGCCTGCGGCACCTGGTGGTGGTGGACAACCGCAATCAGGTTGTCGGGTTGGTGACCAGGAAGGACCTCGCCAGGTACCGC
CTGGGAAAGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAGACGTGAGGCCCAGCCCTGCCCATAATGGGCACTGGCGCTGGCACCCCGGCC
CTTCTGCATTTCCTCCCGGAGTCACTGGTTTCTCGGCCCAAACCATGCTCCCCAGCAGTGGCAATGGCGAGCACCCTGCAGCTGGGCGGG
CAGGCGGCAGGCGCGGAACTGACCCTCTCGCGGGACTGACCCTGTTGTGGGCAGTGGTCTCCCCCCTTGGCGCCTCCTTGCGCAGGCCCA
GCCTCCACTCTCCTCGTCTAGGTTTCTTTACCTCCAGGGATCAGCTGTGTGTGTGTGACCTCCCTACCGGGCTATCGGCCTCTTGGGAGC
CAGCGGCAGGGCCGGCACCTGCGTGCCTGTGCCCGTGTGCGTGAGACAGAGCCCTTGCCCCTGCTGCTGCCCCGAGGGCTGCCCTGCCCT
GGAAGGGCCCCTCTGCCTCCACACCAGTGGAGTCTTCGAGACTTGGGAGCTGCTTGGCCTCATTTTCAGCCATGAGCAGACGGCCTGTGG
TCCCTGGGCCTGAGGCACGGACTCGTAGCACCAGGGTTTGGAGGCTGCGACCGCCCCGGAGAGCAGCTTCACACTGGCGCCACAGAGGAG
CCCCACGTGCACTCCCCGGCCTGCATCCGGCTTGGGTACACAGGCCCAGAGGACTGGGGTGACTCACGGGCCCTGTGCTGTGATGTTGAG
AGCTGAGAAAAACCTCCAAGGCCCTGAGCCCCATGCCCAGCCCTGCCTTGGTCCCCCAACCCCCAGAGCTTGGAGTCTGGGCCCCACACC
CAGCCCTGCCTTGGTCCCTGAGCCTCAGAGCGTGGAATTGCTGCCCTGTGGACACTGGCTGGGAAGGCAGGTCTTCCCCTAGCACATGGG
GACCCCGGCCTCGAGGGTGACCTCCCTACCCCGCCCCTGCCAGCCACCAAGCGCAGGTGCAGCGGGGGCCAGACTCCTGCCGGCCTCAGA
GGACACCTGGCCCAGCACAGGCAGCTAGAAGGGCCGGTGGGCACCGGGGCCGGGAAGCCCCCACCTCACCACCTGAGGGCCCCTGGGAGG
CTCCTCTGGCCTGGCTGGGCTGGGTCTGGGGCCGCCACAGGCCCCTCACGGGGCGGCAGAGGCAACTTCAGTGTCCCTGTTAGAGCAACA
CGGGTCCCTCCGTGGGGGGCTGGGTGCGGCCCCCTGCCGTGTATTTCCTCCCCAGGGAGTGGGGCCTCCCCGGGAGCTGACGCCACCACC
CTGCTTAGCCCTCACAGGGCCCCAAGGTGTCCGAGTGTGTTGGGTCTGAACGCGAAATAAAGAAATCCTCTCAGCCCGCCTTTGCCAGCG
TCGTCCCTCCCACCCCACCCAGACCACGTCCAACAGCCTGGGACTTTCGGGACCCTGGGGTCGGGGCACCGTGTGGAGTGAGAAAGGCGT
GAAAGACAGCGGCTGCGGCCACCCAGGGCACCAGCCACATCCTCTTCCTCGTCCCCGCCCCTCAGCCTCCCTCCTCTGGCTCCTGGCTGG
TGGGTCTGGGGGCAAGGCAGAGGCGCTCCAGGTGGAGGGGGGCGGGCCGGGGTGCCCACGCTGGGGTGACGCAAGAAGAAAACTCCCGGG
CCTCAGAGTCGGCGCCGGAAACCTAGGTCTGGGTTTCCCTCGTGGTGGTTGTGTACTGAGGACCTGGAAGTGATCATATTTTGGATATAT

>72623_72623_5_RBCK1-CLCN7_RBCK1_chr20_400375_ENST00000356286_CLCN7_chr16_1509188_ENST00000382745_length(amino acids)=902AA_BP=294
MGRAGGHTAWLSCSWSPASPRRPGGSISQEARSPPGGWAQPRQMDEKTKKAEEMALSLTRAVAGGDEQVAMKCAIWLAEQRVPLSVQLKP
EVSPTQDIRLWVSVEDAQMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPVLQQWVIGQRLARDQETLHSHGVRQNGDSAYLYLLSARNTS
LNPQELQRERQLRMLEDLGFKDLTLQPRGPLEPGPPKPGVPQEPGRGQPDAVPEPPPVGWQCPGCTFINKPTRPGCEMCCRARPEAYQVP
ASYQPDEEERARLAGEEEALRQYQQPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQ
GRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLS
SPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQG
GSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLS
YLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSH
SLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRD
AYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLA

--------------------------------------------------------------
>72623_72623_6_RBCK1-CLCN7_RBCK1_chr20_400375_ENST00000356286_CLCN7_chr16_1509188_ENST00000448525_length(transcript)=4982nt_BP=1461nt
CGCCTGCGGCCCAGCTCCTTCCCGCGGCTCTGCGATGCGGCCCGCAGGGTGACCCGGGCGGGAGTCCGGGGACCCGCGATCAGCCCCGGA
GGACGGGGTGGGGTCGCCCCAAACAGGAGCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGA
GGTCCCGGATGAGGCGACAATTTTTCCGGCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAA
GCCGCTCCCCTTGCGAAGAACTGGGGCCTCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGG
GGGTCCTCCGGGACTTGGAACGCCCCGGCTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCC
TGCGCCCAGTGCGGACCTGTCTCGGCGCCCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTC
CCGACTGCCGCGGGGACAGCGAGGCACACACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCC
TCTCCCAGGCGACCCGGAGGTAGCATTTCCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACC
AAGAAAGCAGAGGAAATGGCCCTGAGCCTCACCCGAGCAGTGGCGGGCGGGGATGAACAGGTGGCAATGAAGTGTGCCATCTGGCTGGCA
GAGCAACGGGTGCCCCTGAGTGTGCAACTGAAGCCTGAGGTCTCCCCAACGCAGGACATCAGGCTGTGGGTGAGCGTGGAGGATGCTCAG
ATGCACACCGTCACCATCTGGCTCACAGTGCGCCCTGATATGACAGTGGCGTCTCTCAAGGACATGGTTTTTCTGGACTATGGCTTCCCA
CCAGTCTTGCAGCAGTGGGTGATTGGGCAGCGGCTGGCACGAGACCAGGAGACCCTGCACTCCCATGGGGTGCGGCAGAATGGGGACAGT
GCCTACCTCTATCTGCTGTCAGCCCGCAACACCTCCCTCAACCCTCAGGAGCTGCAGCGGGAGCGGCAGCTGCGGATGCTGGAAGATCTG
GGCTTCAAGGACCTCACGCTGCAGCCGCGGGGCCCTCTGGAGCCAGGCCCCCCAAAGCCCGGGGTCCCCCAGGAACCCGGACGGGGGCAG
CCAGATGCAGTGCCTGAGCCCCCACCGGTGGGCTGGCAGTGCCCCGGGTGCACCTTCATCAACAAGCCCACGCGGCCTGGCTGTGAGATG
TGCTGCCGGGCGCGCCCCGAGGCCTACCAGGTCCCCGCCTCATACCAGCCCGACGAGGAGGAGCGAGCGCGCCTGGCGGGCGAGGAGGAG
GCGCTGCGTCAGTACCAGCAGCCGGTGGCTGCTGGCAGCGGAATCCCCCAGATCAAGTGCTTCCTCAACGGGGTGAAGATCCCCCACGTG
GTGCGGCTCAAGACGTTGGTGATCAAAGTGTCCGGTGTGATCCTGTCCGTGGTCGGGGGCCTGGCCGTGGGAAAGGAAGGGCCGATGATC
CACTCAGGTTCAGTGATTGCCGCCGGGATCTCTCAGGGAAGGTCAACGTCACTGAAACGAGATTTCAAGATCTTCGAGTACTTCCGCAGA
GACACAGAGAAGCGGGACTTCGTCTCCGCAGGGGCTGCGGCCGGAGTGTCAGCGGCGTTTGGAGCCCCCGTGGGTGGGGTCCTGTTCAGC
TTGGAGGAGGGTGCGTCCTTCTGGAACCAGTTCCTGACCTGGAGGATCTTCTTTGCTTCCATGATCTCCACGTTCACCCTGAATTTTGTT
CTGAGCATTTACCACGGGAACATGTGGGACCTGTCCAGCCCAGGCCTCATCAACTTCGGAAGGTTTGACTCGGAGAAAATGGCCTACACG
ATCCACGAGATCCCGGTCTTCATCGCCATGGGCGTGGTGGGCGGTGTGCTTGGAGCAGTGTTCAATGCCTTGAACTACTGGCTGACCATG
TTTCGAATCAGGTACATCCACCGGCCCTGCCTGCAGGTGATTGAGGCCGTGCTGGTGGCCGCCGTCACGGCCACAGTTGCCTTCGTGCTG
ATCTACTCGTCGCGGGATTGCCAGCCCCTGCAGGGGGGCTCCATGTCCTACCCGCTGCAGCTCTTTTGTGCAGATGGCGAGTACAACTCC
ATGGCTGCGGCCTTCTTCAACACCCCGGAGAAGAGCGTGGTGAGCCTCTTCCACGACCCGCCAGGCTCCTACAACCCCCTGACCCTCGGC
CTGTTCACGCTGGTCTACTTCTTCCTGGCCTGCTGGACCTACGGGCTCACGGTGTCTGCCGGGGTCTTCATCCCGTCCCTGCTCATCGGG
GCTGCCTGGGGCCGGCTCTTTGGGATCTCCCTGTCCTACCTCACGGGGGCGGCGATCTGGGCGGACCCCGGCAAATACGCCCTGATGGGA
GCTGCTGCCCAGCTGGGCGGGATTGTGCGGATGACACTGAGCCTGACCGTCATCATGATGGAGGCCACCAGCAACGTGACCTACGGCTTC
CCCATCATGCTGGTGCTCATGACCGCCAAGATCGTGGGCGACGTCTTCATTGAGGGCCTGTACGACATGCACATTCAGCTGCAGAGTGTG
CCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCACTCACTGCCAGGGAGGTGATGAGCACACCAGTGACCTGCCTGAGGCGGCGT
GAGAAGGTCGGCGTCATTGTGGACGTGCTGAGCGACACGGCGTCCAATCACAACGGCTTCCCCGTGGTGGAGCATGCCGATGACACCCAG
CCTGCCCGGCTCCAGGGCCTGATCCTGCGCTCCCAGCTCATCGTTCTCCTAAAGCACAAGGTGTTTGTGGAGCGGTCCAACCTGGGCCTG
GTACAGCGGCGCCTGAGGCTGAAGGACTTCCGAGACGCCTACCCGCGCTTCCCACCCATCCAGTCCATCCACGTGTCCCAGGACGAGCGG
GAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCCCCCTACACGGTGCCCCAGGAGGCGTCGCTCCCACGGGTGTTCAAGCTGTTC
CGGGCCCTGGGCCTGCGGCACCTGGTGGTGGTGGACAACCGCAATCAGGTTGTCGGGTTGGTGACCAGGAAGGACCTCGCCAGGTACCGC
CTGGGAAAGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAGACGTGAGGCCCAGCCCTGCCCATAATGGGCACTGGCGCTGGCACCCCGGCC
CTTCTGCATTTCCTCCCGGAGTCACTGGTTTCTCGGCCCAAACCATGCTCCCCAGCAGTGGCAATGGCGAGCACCCTGCAGCTGGGCGGG
CAGGCGGCAGGCGCGGAACTGACCCTCTCGCGGGACTGACCCTGTTGTGGGCAGTGGTCTCCCCCCTTGGCGCCTCCTTGCGCAGGCCCA
GCCTCCACTCTCCTCGTCTAGGTTTCTTTACCTCCAGGGATCAGCTGTGTGTGTGTGACCTCCCTACCGGGCTATCGGCCTCTTGGGAGC
CAGCGGCAGGGCCGGCACCTGCGTGCCTGTGCCCGTGTGCGTGAGACAGAGCCCTTGCCCCTGCTGCTGCCCCGAGGGCTGCCCTGCCCT
GGAAGGGCCCCTCTGCCTCCACACCAGTGGAGTCTTCGAGACTTGGGAGCTGCTTGGCCTCATTTTCAGCCATGAGCAGACGGCCTGTGG
TCCCTGGGCCTGAGGCACGGACTCGTAGCACCAGGGTTTGGAGGCTGCGACCGCCCCGGAGAGCAGCTTCACACTGGCGCCACAGAGGAG
CCCCACGTGCACTCCCCGGCCTGCATCCGGCTTGGGTACACAGGCCCAGAGGACTGGGGTGACTCACGGGCCCTGTGCTGTGATGTTGAG
AGCTGAGAAAAACCTCCAAGGCCCTGAGCCCCATGCCCAGCCCTGCCTTGGTCCCCCAACCCCCAGAGCTTGGAGTCTGGGCCCCACACC
CAGCCCTGCCTTGGTCCCTGAGCCTCAGAGCGTGGAATTGCTGCCCTGTGGACACTGGCTGGGAAGGCAGGTCTTCCCCTAGCACATGGG
GACCCCGGCCTCGAGGGTGACCTCCCTACCCCGCCCCTGCCAGCCACCAAGCGCAGGTGCAGCGGGGGCCAGACTCCTGCCGGCCTCAGA
GGACACCTGGCCCAGCACAGGCAGCTAGAAGGGCCGGTGGGCACCGGGGCCGGGAAGCCCCCACCTCACCACCTGAGGGCCCCTGGGAGG
CTCCTCTGGCCTGGCTGGGCTGGGTCTGGGGCCGCCACAGGCCCCTCACGGGGCGGCAGAGGCAACTTCAGTGTCCCTGTTAGAGCAACA
CGGGTCCCTCCGTGGGGGGCTGGGTGCGGCCCCCTGCCGTGTATTTCCTCCCCAGGGAGTGGGGCCTCCCCGGGAGCTGACGCCACCACC
CTGCTTAGCCCTCACAGGGCCCCAAGGTGTCCGAGTGTGTTGGGTCTGAACGCGAAATAAAGAAATCCTCTCAGCCCGCCTTTGCCAGCG
TCGTCCCTCCCACCCCACCCAGACCACGTCCAACAGCCTGGGACTTTCGGGACCCTGGGGTCGGGGCACCGTGTGGAGTGAGAAAGGCGT
GAAAGACAGCGGCTGCGGCCACCCAGGGCACCAGCCACATCCTCTTCCTCGTCCCCGCCCCTCAGCCTCCCTCCTCTGGCTCCTGGCTGG
TGGGTCTGGGGGCAAGGCAGAGGCGCTCCAGGTGGAGGGGGGCGGGCCGGGGTGCCCACGCTGGGGTGACGCAAGAAGAAAACTCCCGGG
CCTCAGAGTCGGCGCCGGAAACCTAGGTCTGGGTTTCCCTCGTGGTGGTTGTGTACTGAGGACCTGGAAGTGATCATATTTTGGATATAT

>72623_72623_6_RBCK1-CLCN7_RBCK1_chr20_400375_ENST00000356286_CLCN7_chr16_1509188_ENST00000448525_length(amino acids)=902AA_BP=294
MGRAGGHTAWLSCSWSPASPRRPGGSISQEARSPPGGWAQPRQMDEKTKKAEEMALSLTRAVAGGDEQVAMKCAIWLAEQRVPLSVQLKP
EVSPTQDIRLWVSVEDAQMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPVLQQWVIGQRLARDQETLHSHGVRQNGDSAYLYLLSARNTS
LNPQELQRERQLRMLEDLGFKDLTLQPRGPLEPGPPKPGVPQEPGRGQPDAVPEPPPVGWQCPGCTFINKPTRPGCEMCCRARPEAYQVP
ASYQPDEEERARLAGEEEALRQYQQPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQ
GRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLS
SPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQG
GSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLS
YLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSH
SLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRD
AYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLA

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Fusion Gene PPI Analysis for RBCK1-CLCN7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneRBCK1chr20:400375chr16:1509188ENST00000356286+6121_220252.0511.0IRF3
HgeneRBCK1chr20:400375chr16:1509188ENST00000353660+51169_131210.0469.0RNF31
HgeneRBCK1chr20:400375chr16:1509188ENST00000356286+61269_131252.0511.0RNF31


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRBCK1chr20:400375chr16:1509188ENST00000353660+5111_220210.0469.0IRF3
HgeneRBCK1chr20:400375chr16:1509188ENST00000353660+5111_270210.0469.0TAB2
HgeneRBCK1chr20:400375chr16:1509188ENST00000356286+6121_270252.0511.0TAB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RBCK1-CLCN7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RBCK1-CLCN7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource