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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RBCK1-MACROD2 (FusionGDB2 ID:72625)

Fusion Gene Summary for RBCK1-MACROD2

check button Fusion gene summary
Fusion gene informationFusion gene name: RBCK1-MACROD2
Fusion gene ID: 72625
HgeneTgene
Gene symbol

RBCK1

MACROD2

Gene ID

10616

140733

Gene nameRANBP2-type and C3HC4-type zinc finger containing 1mono-ADP ribosylhydrolase 2
SynonymsC20orf18|HOIL-1|HOIL1|PBMEI|PGBM1|RBCK2|RNF54|UBCE7IP3|XAP3|XAP4|ZRANB4C20orf133|C2orf133
Cytomap

20p13

20p12.1

Type of geneprotein-codingprotein-coding
DescriptionranBP-type and C3HC4-type zinc finger-containing protein 1HBV-associated factor 4RBCC protein interacting with PKC1RING finger protein 54RING-type E3 ubiquitin transferase HOIL-1heme-oxidized IRP2 ubiquitin ligase 1hepatitis B virus X-associated proADP-ribose glycohydrolase MACROD2MACRO domain containing 2MACRO domain-containing protein 2O-acetyl-ADP-ribose deacetylase MACROD2[Protein ADP-ribosylaspartate] hydrolase MACROD2[Protein ADP-ribosylglutamate] hydrolase[Protein ADP-ribosylglutamate]
Modification date2020032720200313
UniProtAcc.

A1Z1Q3

Ensembl transtripts involved in fusion geneENST00000400245, ENST00000353660, 
ENST00000356286, ENST00000400247, 
ENST00000475269, ENST00000382181, 
ENST00000217246, ENST00000310348, 
ENST00000378058, ENST00000402914, 
ENST00000407045, ENST00000464883, 
Fusion gene scores* DoF score9 X 5 X 6=27037 X 34 X 11=13838
# samples 841
** MAII scorelog2(8/270*10)=-1.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/13838*10)=-5.07686772601114
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBCK1 [Title/Abstract] AND MACROD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRBCK1(389423)-MACROD2(14474125), # samples:1
Anticipated loss of major functional domain due to fusion event.RBCK1-MACROD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RBCK1-MACROD2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRBCK1

GO:0000209

protein polyubiquitination

12629548|17006537

HgeneRBCK1

GO:0032088

negative regulation of NF-kappaB transcription factor activity

17449468

HgeneRBCK1

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

19136968|21455173

HgeneRBCK1

GO:0050852

T cell receptor signaling pathway

20005846

HgeneRBCK1

GO:0051092

positive regulation of NF-kappaB transcription factor activity

19136968

HgeneRBCK1

GO:0097039

protein linear polyubiquitination

21455173|21455180|21455181|23453807

TgeneMACROD2

GO:0042278

purine nucleoside metabolic process

21257746

TgeneMACROD2

GO:0051725

protein de-ADP-ribosylation

23474712


check buttonFusion gene breakpoints across RBCK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MACROD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-78-8660-01ARBCK1chr20

389423

+MACROD2chr20

14474125

+


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Fusion Gene ORF analysis for RBCK1-MACROD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000400245ENST00000217246RBCK1chr20

389423

+MACROD2chr20

14474125

+
3UTR-3CDSENST00000400245ENST00000310348RBCK1chr20

389423

+MACROD2chr20

14474125

+
3UTR-intronENST00000400245ENST00000378058RBCK1chr20

389423

+MACROD2chr20

14474125

+
3UTR-intronENST00000400245ENST00000402914RBCK1chr20

389423

+MACROD2chr20

14474125

+
3UTR-intronENST00000400245ENST00000407045RBCK1chr20

389423

+MACROD2chr20

14474125

+
3UTR-intronENST00000400245ENST00000464883RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000353660ENST00000378058RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000353660ENST00000402914RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000353660ENST00000407045RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000353660ENST00000464883RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000356286ENST00000378058RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000356286ENST00000402914RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000356286ENST00000407045RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000356286ENST00000464883RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000400247ENST00000378058RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000400247ENST00000402914RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000400247ENST00000407045RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000400247ENST00000464883RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000475269ENST00000378058RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000475269ENST00000402914RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000475269ENST00000407045RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000475269ENST00000464883RBCK1chr20

389423

+MACROD2chr20

14474125

+
5UTR-3CDSENST00000382181ENST00000217246RBCK1chr20

389423

+MACROD2chr20

14474125

+
5UTR-3CDSENST00000382181ENST00000310348RBCK1chr20

389423

+MACROD2chr20

14474125

+
5UTR-intronENST00000382181ENST00000378058RBCK1chr20

389423

+MACROD2chr20

14474125

+
5UTR-intronENST00000382181ENST00000402914RBCK1chr20

389423

+MACROD2chr20

14474125

+
5UTR-intronENST00000382181ENST00000407045RBCK1chr20

389423

+MACROD2chr20

14474125

+
5UTR-intronENST00000382181ENST00000464883RBCK1chr20

389423

+MACROD2chr20

14474125

+
Frame-shiftENST00000353660ENST00000217246RBCK1chr20

389423

+MACROD2chr20

14474125

+
Frame-shiftENST00000353660ENST00000310348RBCK1chr20

389423

+MACROD2chr20

14474125

+
Frame-shiftENST00000400247ENST00000217246RBCK1chr20

389423

+MACROD2chr20

14474125

+
Frame-shiftENST00000400247ENST00000310348RBCK1chr20

389423

+MACROD2chr20

14474125

+
In-frameENST00000356286ENST00000217246RBCK1chr20

389423

+MACROD2chr20

14474125

+
In-frameENST00000356286ENST00000310348RBCK1chr20

389423

+MACROD2chr20

14474125

+
In-frameENST00000475269ENST00000217246RBCK1chr20

389423

+MACROD2chr20

14474125

+
In-frameENST00000475269ENST00000310348RBCK1chr20

389423

+MACROD2chr20

14474125

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356286RBCK1chr20389423+ENST00000217246MACROD2chr2014474125+50557275761733385
ENST00000356286RBCK1chr20389423+ENST00000310348MACROD2chr2014474125+18037275761802408
ENST00000475269RBCK1chr20389423+ENST00000217246MACROD2chr2014474125+50307025511708385
ENST00000475269RBCK1chr20389423+ENST00000310348MACROD2chr2014474125+17787025511777409

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356286ENST00000217246RBCK1chr20389423+MACROD2chr2014474125+0.0001273330.9998727
ENST00000356286ENST00000310348RBCK1chr20389423+MACROD2chr2014474125+0.000746510.99925345
ENST00000475269ENST00000217246RBCK1chr20389423+MACROD2chr2014474125+0.00012720.9998728
ENST00000475269ENST00000310348RBCK1chr20389423+MACROD2chr2014474125+0.0007173530.99928266

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Fusion Genomic Features for RBCK1-MACROD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RBCK1chr20389423+MACROD2chr2014474124+0.0001823780.99981767
RBCK1chr20389423+MACROD2chr2014474124+0.0001823780.99981767

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RBCK1-MACROD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:389423/chr20:14474125)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MACROD2

A1Z1Q3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). {ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712, ECO:0000269|PubMed:23474714}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMACROD2chr20:389423chr20:14474125ENST00000217246217247_38890426.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:389423chr20:14474125ENST00000310348218247_38890449.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:389423chr20:14474125ENST00000378058010247_3880214.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:389423chr20:14474125ENST000003780580106_90214.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:389423chr20:14474125ENST00000402914014247_3880214.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:389423chr20:14474125ENST000004029140146_90214.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:389423chr20:14474125ENST0000040704506247_388099.0Compositional biasNote=Glu-rich
TgeneMACROD2chr20:389423chr20:14474125ENST00000407045066_9099.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:389423chr20:14474125ENST0000037805801059_2400214.0DomainMacro
TgeneMACROD2chr20:389423chr20:14474125ENST0000040291401459_2400214.0DomainMacro
TgeneMACROD2chr20:389423chr20:14474125ENST000004070450659_240099.0DomainMacro
TgeneMACROD2chr20:389423chr20:14474125ENST00000217246217185_19190426.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST0000021724621790_9290426.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST0000021724621797_10290426.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000310348218185_19190449.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST0000031034821890_9290449.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST0000031034821897_10290449.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000378058010185_1910214.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST0000037805801077_790214.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST0000037805801090_920214.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST0000037805801097_1020214.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000402914014185_1910214.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST0000040291401477_790214.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST0000040291401490_920214.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST0000040291401497_1020214.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST0000040704506185_191099.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST000004070450677_79099.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST000004070450690_92099.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST000004070450697_102099.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+111233_26113469.0Coiled coilOntology_term=ECO:0000255
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+112233_2617511.0Coiled coilOntology_term=ECO:0000255
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+11155_11913469.0DomainUbiquitin-like
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+11255_1197511.0DomainUbiquitin-like
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+111278_50613469.0RegionTRIAD supradomain
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+112278_5067511.0RegionTRIAD supradomain
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+111193_22213469.0Zinc fingerRanBP2-type
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+111282_33213469.0Zinc fingerRING-type 1
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+111351_41113469.0Zinc fingerIBR-type
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+111447_47613469.0Zinc fingerRING-type 2%3B atypical
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+112193_2227511.0Zinc fingerRanBP2-type
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+112282_3327511.0Zinc fingerRING-type 1
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+112351_4117511.0Zinc fingerIBR-type
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+112447_4767511.0Zinc fingerRING-type 2%3B atypical
TgeneMACROD2chr20:389423chr20:14474125ENST000002172462176_990426.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:389423chr20:14474125ENST000003103482186_990449.0Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:389423chr20:14474125ENST0000021724621759_24090426.0DomainMacro
TgeneMACROD2chr20:389423chr20:14474125ENST0000031034821859_24090449.0DomainMacro
TgeneMACROD2chr20:389423chr20:14474125ENST0000021724621777_7990426.0RegionSubstrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST0000031034821877_7990449.0RegionSubstrate binding


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Fusion Gene Sequence for RBCK1-MACROD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72625_72625_1_RBCK1-MACROD2_RBCK1_chr20_389423_ENST00000356286_MACROD2_chr20_14474125_ENST00000217246_length(transcript)=5055nt_BP=727nt
CGCCTGCGGCCCAGCTCCTTCCCGCGGCTCTGCGATGCGGCCCGCAGGGTGACCCGGGCGGGAGTCCGGGGACCCGCGATCAGCCCCGGA
GGACGGGGTGGGGTCGCCCCAAACAGGAGCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGA
GGTCCCGGATGAGGCGACAATTTTTCCGGCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAA
GCCGCTCCCCTTGCGAAGAACTGGGGCCTCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGG
GGGTCCTCCGGGACTTGGAACGCCCCGGCTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCC
TGCGCCCAGTGCGGACCTGTCTCGGCGCCCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTC
CCGACTGCCGCGGGGACAGCGAGGCACACACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCC
TCTCCCAGGCGACCCGGAGGTAGCATTTCCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACC
AAGAAAGCAAATGCCAGTCTTCTTGGAGGAGGAGGTGTGGATGGCTGTATTCATAGAGCAGCCGGCCCCTGTTTGCTAGCTGAATGTCGT
AACCTGAATGGCTGTGATACTGGACATGCAAAAATCACATGTGGCTATGACCTTCCTGCAAAATATGTCATCCATACTGTAGGGCCAATA
GCCAGGGGCCATATTAATGGTTCCCACAAGGAAGACCTTGCAAATTGCTATAAATCATCTCTGAAGCTCGTGAAAGAAAATAACATCCGA
TCAGTTGCATTTCCCTGCATCTCAACAGGCATTTATGGCTTTCCCAACGAGCCTGCTGCAGTCATTGCCCTCAACACCATTAAGGAATGG
CTTGCCAAGAATCACCATGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAG
TTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGT
GTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGAC
TGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGAT
GGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAAC
CAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAG
GACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAGATGAAGCGAAG
GAACAAAGAAATGGAACTAAATGACAATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGCTCGGGAAGATAGCAGCACACGCTG
TGGAGGAGGGTGGGGGTGGGGGGAAGGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATTTCTCCAGCTGCATTTTGTTCCGTT
TATCTGCAGAAAAAGAAAGAAAAAAAAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCATGTTGACGCATCTTTCAGGCATTAT
CCTTGTAATTTCTGTCTTTTCTCTTACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTCACATGTGTATCCTGGCCCCTGTCT
GCTTTCTTGGTTATTTCACAAAGCTGGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAGTGGTTTGATAAGCTGCAGGATAAA
TTTTAGGAATCAATGAGCCCAGCAGCAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGGCAAAAGCCTCGGAAACCACTTGGA
AAAGGTCTGGACAATGAGGTGAAAATATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTGGCTAATGAGAAATATGGAAGCTGA
ATTTTTTCCAGAGCAGAGTGCAGAGGCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGT
GCATCCTTCTTTGACACTGACTTTCAGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACTACCAGCAAGAGGTGACTCTCTGCT
GCATAACTGTAAAGGATGGCCCTTTGCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCATTTAGGACCCAAACATATGCCTAT
GAATATCAAAAGCTCCTCCTGAAATTGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCAAGGCTTGACAGCCCACAGAGTGGT
CTCATTTGAAATTACAGGAAATTAGAGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAATGCTGTCACTTGTTTATGCCAAGT
TCAAGGCTGATTCAATGGTTGGTCCCCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCC
AAGATGCCAGTGGTATAGTGGGCACAAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAATATCTATCCTAGAGCCAGTATAAGG
CCAGATGCCTACTTCCCACAGCCTCCCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACATATCGTTTGTTGCATATCTTCTTAA
ATCCATCTTCCTTGTAAGGGCTTTAGAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGAGAAAAATAGTGGATTATTATTTCT
AAAATAAAAGGATGTTCTGCTTTCTAAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATGGAAAATTCATCTTATCTTCCTATG
ACTTTGGTTTTAGCCTTTCTGAATTTGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAGTTAACAAGCTATACTTCAGCATAT
GCACTATATTCTAACAAATTTTTTTTAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGACCTCATAATGTGGGATTATGGCCTT
CTGTTGCTATTCCAGTTTGATATGGAAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCA
TTTTAAAGAATCCAAGAAACGATGTCATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTATAACTCAATTGAAAGTTGCCGTCA
TTCTTGTGAAGTATTTGACAAGTGCAATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTTAGTGCTACTTAGCCTCAGTAATGA
GTTACAGTTGAAAAAAACATGAGGGAAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAGAGACCTAATGTCCTTGCTAGAAAC
AGCCAGGATGGAAATTATCCAGCCCTGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATTTATTTCAAATGTGGGTGGGCTAGA
AGTGGAAGGAGGGAATTCTCTCTGCCTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGGAAACTAAGAGAATGAGGAATAAAT
ATCTTCAGCCCGACTCCTGAATTTGTTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTA
TTTGGCTATACAGTTTTATGCTTTAAAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATATTAACAATCTAACTATAGCCAGAT
CAAAGACACCTGAACACAGAAAACCTTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAAATAGATTTGAAAAGCTGATTGATT
TTCCCGCACATAAATTCTGGATGTCAATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGAGTTACAGGAGGGAGGGAGGAAAAT
AGCCCTATGTTAGTCATGTTTGCATACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAG
ACAAAGGGGCTTTTCCTCTAGCTGGTAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGATTACAAAGAAGGCATCCGAATCACT
GTCTGTGATACTGGGTCACATATTAATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAAAAGCCTCTTTGTGAATTAATACAG
TTCTGCTTGATGCACTTGATTTGAAAAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTGAAAAATAACAAAGTTAGCAGAATA
TGTTCAATATATTTTCTTGGGGAATAGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCCTGACATTTGTGATATAAAGGAAAA
TCAGAAAAAAAGTAATTTTCTTGATCAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCT
TCTGATATCTGGTATAAACTGCTAAATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAATGCTGGACTGCTTCTAAATCTGTT
TGTTTCTTTTCATCTGTGCCATACACTAAAAAACAACTGTTGCCTTCATACTATATTTGTTAGAGCAGAATACAAATAAAATTTGTTTGA

>72625_72625_1_RBCK1-MACROD2_RBCK1_chr20_389423_ENST00000356286_MACROD2_chr20_14474125_ENST00000217246_length(amino acids)=385AA_BP=50
MGRAGGHTAWLSCSWSPASPRRPGGSISQEARSPPGGWAQPRQMDEKTKKANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKI
TCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRII
FCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENI
TKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGS

--------------------------------------------------------------
>72625_72625_2_RBCK1-MACROD2_RBCK1_chr20_389423_ENST00000356286_MACROD2_chr20_14474125_ENST00000310348_length(transcript)=1803nt_BP=727nt
CGCCTGCGGCCCAGCTCCTTCCCGCGGCTCTGCGATGCGGCCCGCAGGGTGACCCGGGCGGGAGTCCGGGGACCCGCGATCAGCCCCGGA
GGACGGGGTGGGGTCGCCCCAAACAGGAGCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGA
GGTCCCGGATGAGGCGACAATTTTTCCGGCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAA
GCCGCTCCCCTTGCGAAGAACTGGGGCCTCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGG
GGGTCCTCCGGGACTTGGAACGCCCCGGCTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCC
TGCGCCCAGTGCGGACCTGTCTCGGCGCCCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTC
CCGACTGCCGCGGGGACAGCGAGGCACACACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCC
TCTCCCAGGCGACCCGGAGGTAGCATTTCCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACC
AAGAAAGCAAATGCCAGTCTTCTTGGAGGAGGAGGTGTGGATGGCTGTATTCATAGAGCAGCCGGCCCCTGTTTGCTAGCTGAATGTCGT
AACCTGAATGGCTGTGATACTGGACATGCAAAAATCACATGTGGCTATGACCTTCCTGCAAAATATGTCATCCATACTGTAGGGCCAATA
GCCAGGGGCCATATTAATGGTTCCCACAAGGAAGACCTTGCAAATTGCTATAAATCATCTCTGAAGCTCGTGAAAGAAAATAACATCCGA
TCAGTTGCATTTCCCTGCATCTCAACAGGCATTTATGGCTTTCCCAACGAGCCTGCTGCAGTCATTGCCCTCAACACCATTAAGGAATGG
CTTGCCAAGAATCACCATGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAG
TTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGT
GTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGAC
TGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGAT
GGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAAC
CAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAG
GACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGAC
AAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAA

>72625_72625_2_RBCK1-MACROD2_RBCK1_chr20_389423_ENST00000356286_MACROD2_chr20_14474125_ENST00000310348_length(amino acids)=408AA_BP=50
MGRAGGHTAWLSCSWSPASPRRPGGSISQEARSPPGGWAQPRQMDEKTKKANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKI
TCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRII
FCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENI
TKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGS

--------------------------------------------------------------
>72625_72625_3_RBCK1-MACROD2_RBCK1_chr20_389423_ENST00000475269_MACROD2_chr20_14474125_ENST00000217246_length(transcript)=5030nt_BP=702nt
GGCTCTGCGATGCGGCCCGCAGGGTGACCCGGGCGGGAGTCCGGGGACCCGCGATCAGCCCCGGAGGACGGGGTGGGGTCGCCCCAAACA
GGAGCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGAGGTCCCGGATGAGGCGACAATTTTT
CCGGCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAAGCCGCTCCCCTTGCGAAGAACTGGG
GCCTCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGGGGGTCCTCCGGGACTTGGAACGCCC
CGGCTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCCTGCGCCCAGTGCGGACCTGTCTCGG
CGCCCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTCCCGACTGCCGCGGGGACAGCGAGGC
ACACACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCCTCTCCCAGGCGACCCGGAGGTAGCA
TTTCCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACCAAGAAAGCAAATGCCAGTCTTCTTG
GAGGAGGAGGTGTGGATGGCTGTATTCATAGAGCAGCCGGCCCCTGTTTGCTAGCTGAATGTCGTAACCTGAATGGCTGTGATACTGGAC
ATGCAAAAATCACATGTGGCTATGACCTTCCTGCAAAATATGTCATCCATACTGTAGGGCCAATAGCCAGGGGCCATATTAATGGTTCCC
ACAAGGAAGACCTTGCAAATTGCTATAAATCATCTCTGAAGCTCGTGAAAGAAAATAACATCCGATCAGTTGCATTTCCCTGCATCTCAA
CAGGCATTTATGGCTTTCCCAACGAGCCTGCTGCAGTCATTGCCCTCAACACCATTAAGGAATGGCTTGCCAAGAATCACCATGAGGTGG
ATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATG
AAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCC
AAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGG
ATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGA
ATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGC
AACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAA
GTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAATGAC
AATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGCTCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTGGGGGTGGGGGGAA
GGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATTTCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAAAAGAAAGAAAAAA
AAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCATGTTGACGCATCTTTCAGGCATTATCCTTGTAATTTCTGTCTTTTCTCTT
ACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTCACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTTATTTCACAAAGCT
GGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAGTGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCAATGAGCCCAGCAG
CAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGGCAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGACAATGAGGTGAAAA
TATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTGGCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGAGCAGAGTGCAGAG
GCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTTGACACTGACTTTC
AGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACTACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAAAGGATGGCCCTTT
GCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCATTTAGGACCCAAACATATGCCTATGAATATCAAAAGCTCCTCCTGAAAT
TGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCAAGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAATTACAGGAAATTAG
AGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAATGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATTCAATGGTTGGTCC
CCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTGGTATAGTGGGCAC
AAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAATATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTACTTCCCACAGCCTC
CCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACATATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCTTGTAAGGGCTTTA
GAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGAGAAAAATAGTGGATTATTATTTCTAAAATAAAAGGATGTTCTGCTTTCT
AAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATGGAAAATTCATCTTATCTTCCTATGACTTTGGTTTTAGCCTTTCTGAATT
TGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAGTTAACAAGCTATACTTCAGCATATGCACTATATTCTAACAAATTTTTTT
TAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGACCTCATAATGTGGGATTATGGCCTTCTGTTGCTATTCCAGTTTGATATGG
AAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATCCAAGAAACGATGT
CATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTATAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGTATTTGACAAGTGC
AATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTTAGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAAAAAAACATGAGGG
AAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAGAGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGAAATTATCCAGCCC
TGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATTTATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGGGAATTCTCTCTGC
CTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGGAAACTAAGAGAATGAGGAATAAATATCTTCAGCCCGACTCCTGAATTTG
TTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACAGTTTTATGCTTTA
AAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATATTAACAATCTAACTATAGCCAGATCAAAGACACCTGAACACAGAAAACC
TTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAAATAGATTTGAAAAGCTGATTGATTTTCCCGCACATAAATTCTGGATGTC
AATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGAGTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTAGTCATGTTTGCAT
ACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTTTTCCTCTAGCTGG
TAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGATTACAAAGAAGGCATCCGAATCACTGTCTGTGATACTGGGTCACATATTA
ATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAAAAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATGCACTTGATTTGAA
AAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTGAAAAATAACAAAGTTAGCAGAATATGTTCAATATATTTTCTTGGGGAAT
AGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCCTGACATTTGTGATATAAAGGAAAATCAGAAAAAAAGTAATTTTCTTGAT
CAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGGTATAAACTGCTAA
ATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAATGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCATCTGTGCCATACA

>72625_72625_3_RBCK1-MACROD2_RBCK1_chr20_389423_ENST00000475269_MACROD2_chr20_14474125_ENST00000217246_length(amino acids)=385AA_BP=50
MGRAGGHTAWLSCSWSPASPRRPGGSISQEARSPPGGWAQPRQMDEKTKKANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKI
TCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRII
FCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENI
TKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGS

--------------------------------------------------------------
>72625_72625_4_RBCK1-MACROD2_RBCK1_chr20_389423_ENST00000475269_MACROD2_chr20_14474125_ENST00000310348_length(transcript)=1778nt_BP=702nt
GGCTCTGCGATGCGGCCCGCAGGGTGACCCGGGCGGGAGTCCGGGGACCCGCGATCAGCCCCGGAGGACGGGGTGGGGTCGCCCCAAACA
GGAGCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGAGGTCCCGGATGAGGCGACAATTTTT
CCGGCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAAGCCGCTCCCCTTGCGAAGAACTGGG
GCCTCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGGGGGTCCTCCGGGACTTGGAACGCCC
CGGCTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCCTGCGCCCAGTGCGGACCTGTCTCGG
CGCCCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTCCCGACTGCCGCGGGGACAGCGAGGC
ACACACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCCTCTCCCAGGCGACCCGGAGGTAGCA
TTTCCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACCAAGAAAGCAAATGCCAGTCTTCTTG
GAGGAGGAGGTGTGGATGGCTGTATTCATAGAGCAGCCGGCCCCTGTTTGCTAGCTGAATGTCGTAACCTGAATGGCTGTGATACTGGAC
ATGCAAAAATCACATGTGGCTATGACCTTCCTGCAAAATATGTCATCCATACTGTAGGGCCAATAGCCAGGGGCCATATTAATGGTTCCC
ACAAGGAAGACCTTGCAAATTGCTATAAATCATCTCTGAAGCTCGTGAAAGAAAATAACATCCGATCAGTTGCATTTCCCTGCATCTCAA
CAGGCATTTATGGCTTTCCCAACGAGCCTGCTGCAGTCATTGCCCTCAACACCATTAAGGAATGGCTTGCCAAGAATCACCATGAGGTGG
ATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATG
AAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCC
AAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGG
ATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGA
ATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGC
AACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAA
GTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTC

>72625_72625_4_RBCK1-MACROD2_RBCK1_chr20_389423_ENST00000475269_MACROD2_chr20_14474125_ENST00000310348_length(amino acids)=409AA_BP=50
MGRAGGHTAWLSCSWSPASPRRPGGSISQEARSPPGGWAQPRQMDEKTKKANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKI
TCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRII
FCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENI
TKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RBCK1-MACROD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+1111_22013.666666666666666469.0IRF3
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+1121_2207.333333333333333511.0IRF3
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+11169_13113.666666666666666469.0RNF31
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+11269_1317.333333333333333511.0RNF31
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+1111_27013.666666666666666469.0TAB2
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+1121_2707.333333333333333511.0TAB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RBCK1-MACROD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RBCK1-MACROD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource