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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RBFOX2-MED15 (FusionGDB2 ID:72681)

Fusion Gene Summary for RBFOX2-MED15

Fusion gene summary

Fusion gene information	Fusion gene name: RBFOX2-MED15
	Fusion gene ID: 72681
		Hgene	Tgene
	Gene symbol	RBFOX2	MED15
	Gene ID	23543	51586
	Gene name	RNA binding fox-1 homolog 2	mediator complex subunit 15
	Synonyms	FOX2\|Fox-2\|HNRBP2\|HRNBP2\|RBM9\|RTA\|dJ106I20.3\|fxh	ARC105\|CAG7A\|CTG7A\|PCQAP\|TIG-1\|TIG1\|TNRC7
	Cytomap	22q12.3	22q11.21
	Type of gene	protein-coding	protein-coding
	Description	RNA binding protein fox-1 homolog 2RNA binding protein, fox-1 homolog 2RNA-binding motif protein 9fox-1 homolog Bfox-1 homologuehexaribonucleotide-binding protein 2repressor of tamoxifen transcriptional activity	mediator of RNA polymerase II transcription subunit 15CTG repeat protein 7aPC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated proteinPC2 glutamine/Q-rich-associated proteinPC2-glutamine-rich-associated proteinTPA inducible ge
	Modification date	20200327	20200313
	UniProtAcc	.	Q96RN5
	Ensembl transtripts involved in fusion gene	ENST00000438146, ENST00000262829, ENST00000359369, ENST00000397303, ENST00000405409, ENST00000414461, ENST00000416721, ENST00000449924,	ENST00000263205, ENST00000382974, ENST00000406969, ENST00000478831, ENST00000541476, ENST00000542773, ENST00000292733, ENST00000425759,
Fusion gene scores	* DoF score	39 X 29 X 13=14703	22 X 18 X 9=3564
	# samples	48	24
	** MAII score	log2(48/14703*10)=-4.93693233652239 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(24/3564*10)=-3.8923910259134 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RBFOX2 [Title/Abstract] AND MED15 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RBFOX2(36424288)-MED15(20905723), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RBFOX2	GO:0030520	intracellular estrogen receptor signaling pathway	11875103
Hgene	RBFOX2	GO:0045892	negative regulation of transcription, DNA-templated	11875103

Fusion gene breakpoints across RBFOX2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MED15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-EB-A5KH-06A	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
ChimerDB4	SKCM	TCGA-EB-A5KH	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+

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Fusion Gene ORF analysis for RBFOX2-MED15

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000438146	ENST00000263205	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
5CDS-intron	ENST00000438146	ENST00000263205	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
5CDS-intron	ENST00000438146	ENST00000382974	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
5CDS-intron	ENST00000438146	ENST00000382974	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
5CDS-intron	ENST00000438146	ENST00000406969	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
5CDS-intron	ENST00000438146	ENST00000406969	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
5CDS-intron	ENST00000438146	ENST00000478831	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
5CDS-intron	ENST00000438146	ENST00000478831	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
5CDS-intron	ENST00000438146	ENST00000541476	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
5CDS-intron	ENST00000438146	ENST00000541476	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
5CDS-intron	ENST00000438146	ENST00000542773	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
5CDS-intron	ENST00000438146	ENST00000542773	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
In-frame	ENST00000438146	ENST00000292733	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
In-frame	ENST00000438146	ENST00000292733	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
In-frame	ENST00000438146	ENST00000425759	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
In-frame	ENST00000438146	ENST00000425759	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-3CDS	ENST00000262829	ENST00000292733	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-3CDS	ENST00000262829	ENST00000292733	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-3CDS	ENST00000262829	ENST00000425759	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-3CDS	ENST00000262829	ENST00000425759	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-3CDS	ENST00000359369	ENST00000292733	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-3CDS	ENST00000359369	ENST00000292733	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-3CDS	ENST00000359369	ENST00000425759	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-3CDS	ENST00000359369	ENST00000425759	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-3CDS	ENST00000397303	ENST00000292733	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-3CDS	ENST00000397303	ENST00000292733	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-3CDS	ENST00000397303	ENST00000425759	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-3CDS	ENST00000397303	ENST00000425759	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-3CDS	ENST00000405409	ENST00000292733	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-3CDS	ENST00000405409	ENST00000292733	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-3CDS	ENST00000405409	ENST00000425759	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-3CDS	ENST00000405409	ENST00000425759	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-3CDS	ENST00000414461	ENST00000292733	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-3CDS	ENST00000414461	ENST00000292733	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-3CDS	ENST00000414461	ENST00000425759	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-3CDS	ENST00000414461	ENST00000425759	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-3CDS	ENST00000416721	ENST00000292733	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-3CDS	ENST00000416721	ENST00000292733	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-3CDS	ENST00000416721	ENST00000425759	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-3CDS	ENST00000416721	ENST00000425759	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-3CDS	ENST00000449924	ENST00000292733	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-3CDS	ENST00000449924	ENST00000292733	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-3CDS	ENST00000449924	ENST00000425759	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-3CDS	ENST00000449924	ENST00000425759	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000262829	ENST00000263205	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000262829	ENST00000263205	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000262829	ENST00000382974	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000262829	ENST00000382974	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000262829	ENST00000406969	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000262829	ENST00000406969	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000262829	ENST00000478831	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000262829	ENST00000478831	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000262829	ENST00000541476	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000262829	ENST00000541476	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000262829	ENST00000542773	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000262829	ENST00000542773	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000359369	ENST00000263205	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000359369	ENST00000263205	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000359369	ENST00000382974	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000359369	ENST00000382974	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000359369	ENST00000406969	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000359369	ENST00000406969	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000359369	ENST00000478831	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000359369	ENST00000478831	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000359369	ENST00000541476	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000359369	ENST00000541476	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000359369	ENST00000542773	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000359369	ENST00000542773	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000397303	ENST00000263205	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000397303	ENST00000263205	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000397303	ENST00000382974	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000397303	ENST00000382974	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000397303	ENST00000406969	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000397303	ENST00000406969	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000397303	ENST00000478831	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000397303	ENST00000478831	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000397303	ENST00000541476	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000397303	ENST00000541476	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000397303	ENST00000542773	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000397303	ENST00000542773	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000405409	ENST00000263205	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000405409	ENST00000263205	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000405409	ENST00000382974	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000405409	ENST00000382974	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000405409	ENST00000406969	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000405409	ENST00000406969	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000405409	ENST00000478831	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000405409	ENST00000478831	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000405409	ENST00000541476	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000405409	ENST00000541476	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000405409	ENST00000542773	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000405409	ENST00000542773	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000414461	ENST00000263205	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000414461	ENST00000263205	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000414461	ENST00000382974	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000414461	ENST00000382974	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000414461	ENST00000406969	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000414461	ENST00000406969	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000414461	ENST00000478831	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000414461	ENST00000478831	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000414461	ENST00000541476	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000414461	ENST00000541476	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000414461	ENST00000542773	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000414461	ENST00000542773	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000416721	ENST00000263205	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000416721	ENST00000263205	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000416721	ENST00000382974	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000416721	ENST00000382974	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000416721	ENST00000406969	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000416721	ENST00000406969	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000416721	ENST00000478831	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000416721	ENST00000478831	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000416721	ENST00000541476	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000416721	ENST00000541476	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000416721	ENST00000542773	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000416721	ENST00000542773	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000449924	ENST00000263205	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000449924	ENST00000263205	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000449924	ENST00000382974	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000449924	ENST00000382974	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000449924	ENST00000406969	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000449924	ENST00000406969	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000449924	ENST00000478831	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000449924	ENST00000478831	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000449924	ENST00000541476	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000449924	ENST00000541476	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+
intron-intron	ENST00000449924	ENST00000542773	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+
intron-intron	ENST00000449924	ENST00000542773	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000438146	RBFOX2	chr22	36424288	-	ENST00000425759	MED15	chr22	20905723	+	2991	186	0	2063	687
ENST00000438146	RBFOX2	chr22	36424288	-	ENST00000292733	MED15	chr22	20905723	+	3205	186	0	2276	758
ENST00000438146	RBFOX2	chr22	36424287	-	ENST00000425759	MED15	chr22	20905722	+	2991	186	0	2063	687
ENST00000438146	RBFOX2	chr22	36424287	-	ENST00000292733	MED15	chr22	20905722	+	3205	186	0	2276	758

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000438146	ENST00000425759	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+	0.016191525	0.98380846
ENST00000438146	ENST00000292733	RBFOX2	chr22	36424288	-	MED15	chr22	20905723	+	0.02376233	0.97623765
ENST00000438146	ENST00000425759	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+	0.016191525	0.98380846
ENST00000438146	ENST00000292733	RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+	0.02376233	0.97623765

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Fusion Genomic Features for RBFOX2-MED15

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+	5.12E-09	1
RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+	5.12E-09	1
RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+	5.12E-09	1
RBFOX2	chr22	36424287	-	MED15	chr22	20905722	+	5.12E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RBFOX2-MED15

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:36424288/chr22:20905723)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MED15 Q96RN5
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269\|PubMed:12167862, ECO:0000269\|PubMed:16630888, ECO:0000269\|PubMed:16799563}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000263205

161_174

789.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000263205

178_193

789.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000263205

205_218

789.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000263205

226_239

789.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000263205

243_262

789.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000263205

266_515

789.0

Compositional bias

Note=Pro-rich

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000263205

360_367

789.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000263205

449_456

789.0

Compositional bias

Note=Poly-Pro

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000263205

602_611

789.0

Compositional bias

Note=Poly-Pro

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000292733

161_174

749.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000292733

178_193

749.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000292733

205_218

749.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000292733

226_239

749.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000292733

243_262

749.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000292733

266_515

749.0

Compositional bias

Note=Pro-rich

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000292733

360_367

749.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000292733

449_456

749.0

Compositional bias

Note=Poly-Pro

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000292733

602_611

749.0

Compositional bias

Note=Poly-Pro

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000382974

161_174

678.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000382974

178_193

678.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000382974

205_218

678.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000382974

226_239

678.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000382974

243_262

678.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000382974

266_515

678.0

Compositional bias

Note=Pro-rich

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000382974

360_367

678.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000382974

449_456

678.0

Compositional bias

Note=Poly-Pro

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000382974

602_611

678.0

Compositional bias

Note=Poly-Pro

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000263205

161_174

789.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000263205

178_193

789.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000263205

205_218

789.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000263205

226_239

789.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000263205

243_262

789.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000263205

266_515

789.0

Compositional bias

Note=Pro-rich

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000263205

360_367

789.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000263205

449_456

789.0

Compositional bias

Note=Poly-Pro

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000263205

602_611

789.0

Compositional bias

Note=Poly-Pro

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000292733

161_174

749.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000292733

178_193

749.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000292733

205_218

749.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000292733

226_239

749.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000292733

243_262

749.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000292733

266_515

749.0

Compositional bias

Note=Pro-rich

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000292733

360_367

749.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000292733

449_456

749.0

Compositional bias

Note=Poly-Pro

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000292733

602_611

749.0

Compositional bias

Note=Poly-Pro

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000382974

161_174

678.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000382974

178_193

678.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000382974

205_218

678.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000382974

226_239

678.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000382974

243_262

678.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000382974

266_515

678.0

Compositional bias

Note=Pro-rich

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000382974

360_367

678.0

Compositional bias

Note=Poly-Gln

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000382974

449_456

678.0

Compositional bias

Note=Poly-Pro

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000382974

602_611

678.0

Compositional bias

Note=Poly-Pro

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000263205

547_564

789.0

Motif

Nuclear localization signal

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000292733

547_564

749.0

Motif

Nuclear localization signal

Tgene

MED15

chr22:36424287

chr22:20905722

ENST00000382974

547_564

678.0

Motif

Nuclear localization signal

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000263205

547_564

789.0

Motif

Nuclear localization signal

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000292733

547_564

749.0

Motif

Nuclear localization signal

Tgene

MED15

chr22:36424288

chr22:20905723

ENST00000382974

547_564

678.0

Motif

Nuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RBFOX2

chr22:36424287

chr22:20905722

ENST00000262829

273_377

359.0

Compositional bias

Note=Ala-rich

Hgene

RBFOX2

chr22:36424287

chr22:20905722

ENST00000405409

273_377

368.0

Compositional bias

Note=Ala-rich

Hgene

RBFOX2

chr22:36424287

chr22:20905722

ENST00000414461

273_377

371.0

Compositional bias

Note=Ala-rich

Hgene

RBFOX2

chr22:36424287

chr22:20905722

ENST00000416721

273_377

377.0

Compositional bias

Note=Ala-rich

Hgene

RBFOX2

chr22:36424287

chr22:20905722

ENST00000438146

273_377

452.0

Compositional bias

Note=Ala-rich

Hgene

RBFOX2

chr22:36424287

chr22:20905722

ENST00000449924

273_377

381.0

Compositional bias

Note=Ala-rich

Hgene

RBFOX2

chr22:36424288

chr22:20905723

ENST00000262829

273_377

359.0

Compositional bias

Note=Ala-rich

Hgene

RBFOX2

chr22:36424288

chr22:20905723

ENST00000405409

273_377

368.0

Compositional bias

Note=Ala-rich

Hgene

RBFOX2

chr22:36424288

chr22:20905723

ENST00000414461

273_377

371.0

Compositional bias

Note=Ala-rich

Hgene

RBFOX2

chr22:36424288

chr22:20905723

ENST00000416721

273_377

377.0

Compositional bias

Note=Ala-rich

Hgene

RBFOX2

chr22:36424288

chr22:20905723

ENST00000438146

273_377

452.0

Compositional bias

Note=Ala-rich

Hgene

RBFOX2

chr22:36424288

chr22:20905723

ENST00000449924

273_377

381.0

Compositional bias

Note=Ala-rich

Hgene

RBFOX2

chr22:36424287

chr22:20905722

ENST00000262829

121_197

359.0

Domain

RRM

Hgene

RBFOX2

chr22:36424287

chr22:20905722

ENST00000405409

121_197

368.0

Domain

RRM

Hgene

RBFOX2

chr22:36424287

chr22:20905722

ENST00000414461

121_197

371.0

Domain

RRM

Hgene

RBFOX2

chr22:36424287

chr22:20905722

ENST00000416721

121_197

377.0

Domain

RRM

Hgene

RBFOX2

chr22:36424287

chr22:20905722

ENST00000438146

121_197

452.0

Domain

RRM

Hgene

RBFOX2

chr22:36424287

chr22:20905722

ENST00000449924

121_197

381.0

Domain

RRM

Hgene

RBFOX2

chr22:36424288

chr22:20905723

ENST00000262829

121_197

359.0

Domain

RRM

Hgene

RBFOX2

chr22:36424288

chr22:20905723

ENST00000405409

121_197

368.0

Domain

RRM

Hgene

RBFOX2

chr22:36424288

chr22:20905723

ENST00000414461

121_197

371.0

Domain

RRM

Hgene

RBFOX2

chr22:36424288

chr22:20905723

ENST00000416721

121_197

377.0

Domain

RRM

Hgene

RBFOX2

chr22:36424288

chr22:20905723

ENST00000438146

121_197

452.0

Domain

RRM

Hgene

RBFOX2

chr22:36424288

chr22:20905723

ENST00000449924

121_197

381.0

Domain

RRM

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Fusion Gene Sequence for RBFOX2-MED15

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>72681_72681_1_RBFOX2-MED15_RBFOX2_chr22_36424287_ENST00000438146_MED15_chr22_20905722_ENST00000292733_length(transcript)=3205nt_BP=186nt
ATGGCGGAGGGCGCCCAGCCGCATCAGCCGCCTCAGCTCGGGCCCGGCGCCGCCGCCCGGGGCATGAAGCGGGAGTCGGAGCTGGAGCTG
CCGGTGCCCGGAGCGGGAGGAGACGGAGCCGATCCCGGCCTGAGCAAGCGGCCGCGCACTGAGGAGGCGGCGGCCGACGGTGGCGGCGGG
ATGCAGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGAT
CCTATGAATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCCTCCTCGGGGCCCGGGACAGTCTCTG
GGCGGGATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGGGACCTCGGGGATGGCCCCTCACAGC
ATGGCTGTCGTGTCTACGGCAACTCCACAGACCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAG
CAGCAGCAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTC
CAAGCAGTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAG
ATACAGCAGCAGCAACAGCAGCTGCAGCGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAG
CAGCAGGCTTTGCAGGCCCAGCCACCAATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTG
CAGCAGATGCATCACACACAGCACCACCAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCA
CAGTCGCAGACCCAGCCTTTGGTGTCACAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCT
CCGATGGTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCT
CCCGGAGTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCT
CCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTC
CTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAAC
ACACCTGTGAACCCCAGCTCTGTCATGAGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCG
AAGTACATCGAGCCCCTGCGCCGCATGATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTG
GACATTCTGACAGACCCCTCGAAGCGGTGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCG
GTGCCCACTCCCCCACCGCCCCCGGTGCCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGC
TCACCTGTCTTCAACCATTCCCTGTACCGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGC
ACCCGGAAGCGCAGGCTTGAGGATGATGAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTG
GTAAACCTGGACCCTTCTCACTGCAGCAACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCA
CTGGAGCTCAGTGTGCCCGCTGACTATCCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAG
TCGGTGCACCGCTGCATGACCTCCAGGCTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTC
CACCAGGCCTGCCTCTCAGCCGCCTAGCCAAGACTGCAGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACA
CTTCTAGGTGTTGGCTTCCTTAGAGAGCCTGGGGTTAGGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCC
CACACCTGTACAGAACTGGGATAGGCGCAGTGGAGCGGGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTT
CCTCCCAGGAGCCAGATGCGATCCTCAGGCTGCTCTCACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCA
GGGTGTTGTTAGAGCGTCTCGTGTGTGCTAGACGCACCCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACA
TGGGATTCTCTGGTCACAGTTTTGGGTTCAGGCTATGCTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACA
GGCTGCCTTTTGGAGGGAGGGCTGGCCCATAGGTGCTGCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGC
ACCGTGGGGCACCCAGGGAGCAGGGGCGTCAGGGATCCTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAA
GGATGAAGAGCAAGGCCCTCAGGACCCGTGTCCTCAGAGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCA
TGCAGGGAGCGCCTCCCTATGTTGCCTGCCACTCTGGGCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTA

>72681_72681_1_RBFOX2-MED15_RBFOX2_chr22_36424287_ENST00000438146_MED15_chr22_20905722_ENST00000292733_length(amino acids)=758AA_BP=55
MAEGAQPHQPPQLGPGAAARGMKRESELELPVPGAGGDGADPGLSKRPRTEEAAADGGGGMQDEYLSLVARLIIHFRDIHNKKSQASVSD
PMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQ
QQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQ
QQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRA
PMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSF
LPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLL
DILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVC
TRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQ

--------------------------------------------------------------
>72681_72681_2_RBFOX2-MED15_RBFOX2_chr22_36424287_ENST00000438146_MED15_chr22_20905722_ENST00000425759_length(transcript)=2991nt_BP=186nt
ATGGCGGAGGGCGCCCAGCCGCATCAGCCGCCTCAGCTCGGGCCCGGCGCCGCCGCCCGGGGCATGAAGCGGGAGTCGGAGCTGGAGCTG
CCGGTGCCCGGAGCGGGAGGAGACGGAGCCGATCCCGGCCTGAGCAAGCGGCCGCGCACTGAGGAGGCGGCGGCCGACGGTGGCGGCGGG
ATGCAGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGCC
CAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAGCAGCAGGCGGCGCTACAGCAGCAGCAG
CAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCAGTAGTGCAGCAGCAGCAGCAGCTCCAG
CAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAGCAGCAGCAACAGCAGCTGCAGCGAATA
GCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGCTTTGCAGGCCCAGCCACCAATTCAG
CAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAGATGCATCACACACAGCACCACCAGCCG
CCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCGCAGACCCAGCCTTTGGTGTCACAGGCG
CAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATGGTGGTGCAGCAGCCCCCAGTGCAGCCC
CAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGAGTCCAGGTCAGCCAGAGCAGCCTCCCC
ATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCC
AGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGC
CCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTGTCATGAGCCCA
GCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCCGCATGATCAAC
AAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGAAGCGGTGTCCC
CTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCCCGGTGCCACCG
ACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCCTGTACCGCACA
TTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGGATGATGAGCGG
CAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACTGCAGCAACAAT
GGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTGACTATCCTGCC
CAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCTCCAGGCTGCTG
CAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAGGCCTGCCTCTCAGCCGCCTAGCCAAGA
CTGCAGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTAGGTGTTGGCTTCCTTAGAGAGCCTGGG
GTTAGGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACCTGTACAGAACTGGGATAGGCGCAGTGG
AGCGGGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCCAGGAGCCAGATGCGATCCTCAGGCTGC
TCTCACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGTTGTTAGAGCGTCTCGTGTGTGCTAGAC
GCACCCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACATGGGATTCTCTGGTCACAGTTTTGGGTTCAGGC
TATGCTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGCCTTTTGGAGGGAGGGCTGGCCCATAGG
TGCTGCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTGGGGCACCCAGGGAGCAGGGGCGTCAGG
GATCCTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGAAGAGCAAGGCCCTCAGGACCCGTGTCC
TCAGAGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGGGAGCGCCTCCCTATGTTGCCTGCCACT
CTGGGCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTACCCCACCATCTGTGATTATAATAAATTTATTAT

>72681_72681_2_RBFOX2-MED15_RBFOX2_chr22_36424287_ENST00000438146_MED15_chr22_20905722_ENST00000425759_length(amino acids)=687AA_BP=55
MAEGAQPHQPPQLGPGAAARGMKRESELELPVPGAGGDGADPGLSKRPRTEEAAADGGGGMQDEYLSLVARLIIHFRDIHNKKSQASVSA
QLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRI
AQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQA
QALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQP
SSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMIN
KIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRT
FVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPA

--------------------------------------------------------------
>72681_72681_3_RBFOX2-MED15_RBFOX2_chr22_36424288_ENST00000438146_MED15_chr22_20905723_ENST00000292733_length(transcript)=3205nt_BP=186nt
ATGGCGGAGGGCGCCCAGCCGCATCAGCCGCCTCAGCTCGGGCCCGGCGCCGCCGCCCGGGGCATGAAGCGGGAGTCGGAGCTGGAGCTG
CCGGTGCCCGGAGCGGGAGGAGACGGAGCCGATCCCGGCCTGAGCAAGCGGCCGCGCACTGAGGAGGCGGCGGCCGACGGTGGCGGCGGG
ATGCAGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGAT
CCTATGAATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCCTCCTCGGGGCCCGGGACAGTCTCTG
GGCGGGATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGGGACCTCGGGGATGGCCCCTCACAGC
ATGGCTGTCGTGTCTACGGCAACTCCACAGACCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAG
CAGCAGCAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTC
CAAGCAGTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAG
ATACAGCAGCAGCAACAGCAGCTGCAGCGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAG
CAGCAGGCTTTGCAGGCCCAGCCACCAATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTG
CAGCAGATGCATCACACACAGCACCACCAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCA
CAGTCGCAGACCCAGCCTTTGGTGTCACAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCT
CCGATGGTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCT
CCCGGAGTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCT
CCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTC
CTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAAC
ACACCTGTGAACCCCAGCTCTGTCATGAGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCG
AAGTACATCGAGCCCCTGCGCCGCATGATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTG
GACATTCTGACAGACCCCTCGAAGCGGTGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCG
GTGCCCACTCCCCCACCGCCCCCGGTGCCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGC
TCACCTGTCTTCAACCATTCCCTGTACCGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGC
ACCCGGAAGCGCAGGCTTGAGGATGATGAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTG
GTAAACCTGGACCCTTCTCACTGCAGCAACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCA
CTGGAGCTCAGTGTGCCCGCTGACTATCCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAG
TCGGTGCACCGCTGCATGACCTCCAGGCTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTC
CACCAGGCCTGCCTCTCAGCCGCCTAGCCAAGACTGCAGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACA
CTTCTAGGTGTTGGCTTCCTTAGAGAGCCTGGGGTTAGGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCC
CACACCTGTACAGAACTGGGATAGGCGCAGTGGAGCGGGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTT
CCTCCCAGGAGCCAGATGCGATCCTCAGGCTGCTCTCACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCA
GGGTGTTGTTAGAGCGTCTCGTGTGTGCTAGACGCACCCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACA
TGGGATTCTCTGGTCACAGTTTTGGGTTCAGGCTATGCTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACA
GGCTGCCTTTTGGAGGGAGGGCTGGCCCATAGGTGCTGCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGC
ACCGTGGGGCACCCAGGGAGCAGGGGCGTCAGGGATCCTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAA
GGATGAAGAGCAAGGCCCTCAGGACCCGTGTCCTCAGAGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCA
TGCAGGGAGCGCCTCCCTATGTTGCCTGCCACTCTGGGCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTA

>72681_72681_3_RBFOX2-MED15_RBFOX2_chr22_36424288_ENST00000438146_MED15_chr22_20905723_ENST00000292733_length(amino acids)=758AA_BP=55
MAEGAQPHQPPQLGPGAAARGMKRESELELPVPGAGGDGADPGLSKRPRTEEAAADGGGGMQDEYLSLVARLIIHFRDIHNKKSQASVSD
PMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQ
QQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQ
QQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRA
PMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSF
LPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLL
DILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVC
TRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQ

--------------------------------------------------------------
>72681_72681_4_RBFOX2-MED15_RBFOX2_chr22_36424288_ENST00000438146_MED15_chr22_20905723_ENST00000425759_length(transcript)=2991nt_BP=186nt
ATGGCGGAGGGCGCCCAGCCGCATCAGCCGCCTCAGCTCGGGCCCGGCGCCGCCGCCCGGGGCATGAAGCGGGAGTCGGAGCTGGAGCTG
CCGGTGCCCGGAGCGGGAGGAGACGGAGCCGATCCCGGCCTGAGCAAGCGGCCGCGCACTGAGGAGGCGGCGGCCGACGGTGGCGGCGGG
ATGCAGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGCC
CAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAGCAGCAGGCGGCGCTACAGCAGCAGCAG
CAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCAGTAGTGCAGCAGCAGCAGCAGCTCCAG
CAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAGCAGCAGCAACAGCAGCTGCAGCGAATA
GCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGCTTTGCAGGCCCAGCCACCAATTCAG
CAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAGATGCATCACACACAGCACCACCAGCCG
CCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCGCAGACCCAGCCTTTGGTGTCACAGGCG
CAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATGGTGGTGCAGCAGCCCCCAGTGCAGCCC
CAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGAGTCCAGGTCAGCCAGAGCAGCCTCCCC
ATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCC
AGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGC
CCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTGTCATGAGCCCA
GCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCCGCATGATCAAC
AAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGAAGCGGTGTCCC
CTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCCCGGTGCCACCG
ACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCCTGTACCGCACA
TTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGGATGATGAGCGG
CAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACTGCAGCAACAAT
GGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTGACTATCCTGCC
CAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCTCCAGGCTGCTG
CAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAGGCCTGCCTCTCAGCCGCCTAGCCAAGA
CTGCAGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTAGGTGTTGGCTTCCTTAGAGAGCCTGGG
GTTAGGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACCTGTACAGAACTGGGATAGGCGCAGTGG
AGCGGGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCCAGGAGCCAGATGCGATCCTCAGGCTGC
TCTCACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGTTGTTAGAGCGTCTCGTGTGTGCTAGAC
GCACCCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACATGGGATTCTCTGGTCACAGTTTTGGGTTCAGGC
TATGCTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGCCTTTTGGAGGGAGGGCTGGCCCATAGG
TGCTGCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTGGGGCACCCAGGGAGCAGGGGCGTCAGG
GATCCTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGAAGAGCAAGGCCCTCAGGACCCGTGTCC
TCAGAGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGGGAGCGCCTCCCTATGTTGCCTGCCACT
CTGGGCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTACCCCACCATCTGTGATTATAATAAATTTATTAT

>72681_72681_4_RBFOX2-MED15_RBFOX2_chr22_36424288_ENST00000438146_MED15_chr22_20905723_ENST00000425759_length(amino acids)=687AA_BP=55
MAEGAQPHQPPQLGPGAAARGMKRESELELPVPGAGGDGADPGLSKRPRTEEAAADGGGGMQDEYLSLVARLIIHFRDIHNKKSQASVSA
QLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRI
AQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQA
QALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQP
SSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMIN
KIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRT
FVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RBFOX2-MED15

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	MED15	chr22:36424287	chr22:20905722	ENST00000263205		1	18	9_73	52.0	789.0	SREBF1
Tgene	MED15	chr22:36424287	chr22:20905722	ENST00000292733		1	17	9_73	52.0	749.0	SREBF1
Tgene	MED15	chr22:36424287	chr22:20905722	ENST00000382974		1	16	9_73	52.0	678.0	SREBF1
Tgene	MED15	chr22:36424288	chr22:20905723	ENST00000263205		1	18	9_73	52.0	789.0	SREBF1
Tgene	MED15	chr22:36424288	chr22:20905723	ENST00000292733		1	17	9_73	52.0	749.0	SREBF1
Tgene	MED15	chr22:36424288	chr22:20905723	ENST00000382974		1	16	9_73	52.0	678.0	SREBF1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RBFOX2-MED15

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RBFOX2-MED15

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source