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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RBL1-RPN2 (FusionGDB2 ID:72729)

Fusion Gene Summary for RBL1-RPN2

check button Fusion gene summary
Fusion gene informationFusion gene name: RBL1-RPN2
Fusion gene ID: 72729
HgeneTgene
Gene symbol

RBL1

RPN2

Gene ID

5933

6185

Gene nameRB transcriptional corepressor like 1ribophorin II
SynonymsCP107|PRB1|p107RIBIIR|RPN-II|RPNII|SWP1
Cytomap

20q11.23

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionretinoblastoma-like protein 1107 kDa retinoblastoma-associated proteinretinoblastoma-like 1dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunitoligosaccharyltransferase complex subunit (non-catalytic)ribophorin-2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000344359, ENST00000373664, 
ENST00000598590, 		ENST00000470352, 
ENST00000237530, ENST00000373622, 
Fusion gene scores* DoF score13 X 9 X 7=81912 X 13 X 9=1404
# samples 1517
** MAII scorelog2(15/819*10)=-2.44890095114513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1404*10)=-3.04593628416686
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBL1 [Title/Abstract] AND RPN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRBL1(35672489)-RPN2(35852281), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRBL1

GO:0043550

regulation of lipid kinase activity

16286473


check buttonFusion gene breakpoints across RBL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-A5G8RBL1chr20

35672489

-RPN2chr20

35852281

+


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Fusion Gene ORF analysis for RBL1-RPN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344359ENST00000470352RBL1chr20

35672489

-RPN2chr20

35852281

+
5CDS-intronENST00000373664ENST00000470352RBL1chr20

35672489

-RPN2chr20

35852281

+
In-frameENST00000344359ENST00000237530RBL1chr20

35672489

-RPN2chr20

35852281

+
In-frameENST00000344359ENST00000373622RBL1chr20

35672489

-RPN2chr20

35852281

+
In-frameENST00000373664ENST00000237530RBL1chr20

35672489

-RPN2chr20

35852281

+
In-frameENST00000373664ENST00000373622RBL1chr20

35672489

-RPN2chr20

35852281

+
intron-3CDSENST00000598590ENST00000237530RBL1chr20

35672489

-RPN2chr20

35852281

+
intron-3CDSENST00000598590ENST00000373622RBL1chr20

35672489

-RPN2chr20

35852281

+
intron-intronENST00000598590ENST00000470352RBL1chr20

35672489

-RPN2chr20

35852281

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373664RBL1chr2035672489-ENST00000237530RPN2chr2035852281+29451837672640857
ENST00000373664RBL1chr2035672489-ENST00000373622RPN2chr2035852281+29931837672688873
ENST00000344359RBL1chr2035672489-ENST00000237530RPN2chr2035852281+29391831612634857
ENST00000344359RBL1chr2035672489-ENST00000373622RPN2chr2035852281+29871831612682873

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373664ENST00000237530RBL1chr2035672489-RPN2chr2035852281+0.0006007750.9993992
ENST00000373664ENST00000373622RBL1chr2035672489-RPN2chr2035852281+0.0006639490.99933606
ENST00000344359ENST00000237530RBL1chr2035672489-RPN2chr2035852281+0.000599720.99940026
ENST00000344359ENST00000373622RBL1chr2035672489-RPN2chr2035852281+0.0006600560.9993399

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Fusion Genomic Features for RBL1-RPN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RBL1chr2035672488-RPN2chr2035852280+8.28E-050.99991727
RBL1chr2035672488-RPN2chr2035852280+8.28E-050.99991727

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RBL1-RPN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:35672489/chr20:35852281)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRBL1chr20:35672489chr20:35852281ENST00000344359-1321385_5845901015.0RegionDomain A
HgeneRBL1chr20:35672489chr20:35852281ENST00000373664-1322385_5845901069.0RegionDomain A
TgeneRPN2chr20:35672489chr20:35852281ENST00000237530817562_571364632.0Topological domainCytoplasmic
TgeneRPN2chr20:35672489chr20:35852281ENST00000237530817593_596364632.0Topological domainLumenal
TgeneRPN2chr20:35672489chr20:35852281ENST00000237530817618_631364632.0Topological domainCytoplasmic
TgeneRPN2chr20:35672489chr20:35852281ENST00000373622717562_571332616.0Topological domainCytoplasmic
TgeneRPN2chr20:35672489chr20:35852281ENST00000373622717593_596332616.0Topological domainLumenal
TgeneRPN2chr20:35672489chr20:35852281ENST00000373622717618_631332616.0Topological domainCytoplasmic
TgeneRPN2chr20:35672489chr20:35852281ENST00000237530817541_561364632.0TransmembraneHelical
TgeneRPN2chr20:35672489chr20:35852281ENST00000237530817572_592364632.0TransmembraneHelical
TgeneRPN2chr20:35672489chr20:35852281ENST00000237530817597_617364632.0TransmembraneHelical
TgeneRPN2chr20:35672489chr20:35852281ENST00000373622717541_561332616.0TransmembraneHelical
TgeneRPN2chr20:35672489chr20:35852281ENST00000373622717572_592332616.0TransmembraneHelical
TgeneRPN2chr20:35672489chr20:35852281ENST00000373622717597_617332616.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRBL1chr20:35672489chr20:35852281ENST00000344359-1321385_9495901015.0RegionPocket%3B binds T and E1A
HgeneRBL1chr20:35672489chr20:35852281ENST00000344359-1321585_7805901015.0RegionSpacer
HgeneRBL1chr20:35672489chr20:35852281ENST00000344359-1321781_9495901015.0RegionDomain B
HgeneRBL1chr20:35672489chr20:35852281ENST00000373664-1322385_9495901069.0RegionPocket%3B binds T and E1A
HgeneRBL1chr20:35672489chr20:35852281ENST00000373664-1322585_7805901069.0RegionSpacer
HgeneRBL1chr20:35672489chr20:35852281ENST00000373664-1322781_9495901069.0RegionDomain B
TgeneRPN2chr20:35672489chr20:35852281ENST0000023753081723_540364632.0Topological domainLumenal
TgeneRPN2chr20:35672489chr20:35852281ENST0000037362271723_540332616.0Topological domainLumenal


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Fusion Gene Sequence for RBL1-RPN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72729_72729_1_RBL1-RPN2_RBL1_chr20_35672489_ENST00000344359_RPN2_chr20_35852281_ENST00000237530_length(transcript)=2939nt_BP=1831nt
CGCGCCTGGGAGGGAGAAAGAAGTCGGGGGCCGTGGCGCGCAGCCCGCGGGGCCTGAAGGGATGTTCGAGGACAAGCCCCACGCTGAGGG
GGCGGCGGTGGTCGCCGCAGCCGGGGAGGCGCTACAGGCCCTGTGCCAGGAGCTGAACCTGGACGAGGGGAGCGCGGCCGAAGCCCTGGA
CGACTTTACTGCCATCCGAGGCAACTACAGCCTAGAGGGAGAAGTTACACACTGGTTGGCATGTTCATTATATGTTGCATGCCGCAAAAG
CATTATTCCCACGGTTGGAAAGGGTATCATGGAAGGCAACTGTGTTTCACTTACCAGAATACTACGTTCAGCTAAATTAAGTTTAATACA
ATTTTTTAGTAAAATGAAGAAATGGATGGACATGTCAAATCTACCACAAGAATTTCGTGAACGTATAGAAAGGCTAGAGAGAAATTTTGA
GGTGTCTACTGTAATATTCAAAAAATATGAGCCAATTTTTTTAGATATATTTCAAAATCCATATGAAGAACCACCAAAGTTACCACGAAG
CCGGAAGCAGAGGAGGATTCCTTGCAGTGTTAAGGATCTGTTTAATTTCTGTTGGACACTTTTTGTTTATACTAAGGGTAATTTTCGGAT
GATTGGGGATGACTTAGTAAACTCTTATCATTTACTTCTATGCTGCTTGGATCTGATTTTTGCCAATGCGATTATGTGCCCAAATAGACA
AGACTTGCTAAATCCATCATTTAAAGGTTTACCATCTGATTTTCATACTGCTGACTTTACGGCTTCTGAAGAGCCACCCTGCATCATTGC
TGTACTGTGTGAACTGCATGATGGACTTCTCGTAGAAGCAAAAGGAATAAAGGAGCACTACTTTAAGCCATATATTTCAAAACTCTTTGA
CAGGAAGATATTAAAAGGAGAATGCCTCCTGGACCTTTCAAGTTTTACTGATAATAGCAAAGCAGTGAATAAGGAGTATGAAGAGTATGT
TCTAACTGTTGGTGATTTTGATGAGAGGATCTTTTTGGGAGCAGACGCAGAAGAGGAAATTGGAACACCTCGAAAGTTCACTCGTGACAC
CCCATTAGGGAAACTGACAGCACAGGCTAATGTGGAGTATAACCTTCAACAGCACTTTGAAAAAAAAAGGTCATTTGCACCTTCTACCCC
ACTGACCGGACGGAGATATTTACGAGAAAAAGAAGCAGTCATTACTCCTGTTGCATCAGCCACCCAAAGTGTGAGCCGGTTACAGAGTAT
TGTGGCTGGTCTGAAAAATGCACCAAGTGACCAACTTATAAATATTTTTGAATCTTGTGTGCGTAATCCTGTGGAAAACATTATGAAAAT
ACTAAAAGGAATAGGAGAGACTTTCTGTCAACACTATACTCAATCAACAGATGAACAGCCAGGATCTCACATAGACTTTGCTGTAAACAG
ACTAAAGCTGGCAGAAATTTTGTATTATAAAATACTAGAGACTGTAATGGTTCAGGAAACACGAAGACTTCATGGAATGGACATGTCAGT
TCTTTTAGAGCAAGATATATTTCATCGTTCCTTGATGGCTTGTTGTTTGGAAATTGTGCTCTTTGCCTATAGCTCACCTCGTACTTTTCC
TTGGATTATTGAAGTTCTCAACTTGCAACCATTTTACTTTTATAAGGTTATTGAGGTGGTGATCCGCTCAGAAGAGGGGCTCTCAAGGGA
CATGGTGAAACACCTAAACAGCATTGAAGAACAGATTTTGGAGAGTTTAGCATGGAGTCACGATTCTGCACTGTGGGAGGCTCTCCAGGT
TTCTGCAAACAAAGTTCCTACCTGTGAAGAACTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACAAATGTTGATCTTTCCACCGTGGA
TAAGGATCAGAGCATTGCACCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTCATCGCAGACAGCCACCAGAACTT
CGCCTTGTTCTTCCAGCTGGTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTCCGACTCCATAACCAGAAGACTGG
CCAGGAAGTGGTGTTTGTTGCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGAAAGATTGAATTTGACTC
TGCCTCTGGCACCTACACTCTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGGAATGTGGCTGATGTGGTCATCAA
GTTCCCTGAGGAAGAAGCTCCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCACCTGTTCCGCGAGCCTGA
GAAGAGGCCCCCCACCGTGGTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTCTTCGCTCTGTGGATCCGGATTGG
TGCCAATGTCTCCAACTTCACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATGCTGGGACTCATGTATGTCTACTG
GACTCAGCTCAACATGTTCCAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCTGGCAATCGGATGCTGGCCCAGCA
GGCAGTCAAGAGAACAGCACATTAGTTCCAGAAGAAAGATGGAAATTCTGAAAACTGAATGTCAAGAAAAGGAGTCAAGAACAATTCACA
GTATGAGAAGAAAAATGGAAAAAAAAAACTTTATTTAAAAAAGAAAAAAGTCCAGATTGTAGTTATACTTTTGCTTGTTTTTCAGTTTCC
CCAACACACAGCAGATACCTGGTGAGCTCAGATAGTCTCTTTCTCTGACACTGTGTAAGAAGCTGTGAATATTCCTAACTTACCCAGATG

>72729_72729_1_RBL1-RPN2_RBL1_chr20_35672489_ENST00000344359_RPN2_chr20_35852281_ENST00000237530_length(amino acids)=857AA_BP=590
MFEDKPHAEGAAVVAAAGEALQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVTHWLACSLYVACRKSIIPTVGKGIMEGNCVSLTRI
LRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKYEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTL
FVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRQDLLNPSFKGLPSDFHTADFTASEEPPCIIAVLCELHDGLLVEAKGIKEHY
FKPYISKLFDRKILKGECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTRDTPLGKLTAQANVEYNLQQHFE
KKRSFAPSTPLTGRRYLREKEAVITPVASATQSVSRLQSIVAGLKNAPSDQLINIFESCVRNPVENIMKILKGIGETFCQHYTQSTDEQP
GSHIDFAVNRLKLAEILYYKILETVMVQETRRLHGMDMSVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIEVV
IRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTCEELRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKG
TFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPI
LWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSNTFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHA

--------------------------------------------------------------
>72729_72729_2_RBL1-RPN2_RBL1_chr20_35672489_ENST00000344359_RPN2_chr20_35852281_ENST00000373622_length(transcript)=2987nt_BP=1831nt
CGCGCCTGGGAGGGAGAAAGAAGTCGGGGGCCGTGGCGCGCAGCCCGCGGGGCCTGAAGGGATGTTCGAGGACAAGCCCCACGCTGAGGG
GGCGGCGGTGGTCGCCGCAGCCGGGGAGGCGCTACAGGCCCTGTGCCAGGAGCTGAACCTGGACGAGGGGAGCGCGGCCGAAGCCCTGGA
CGACTTTACTGCCATCCGAGGCAACTACAGCCTAGAGGGAGAAGTTACACACTGGTTGGCATGTTCATTATATGTTGCATGCCGCAAAAG
CATTATTCCCACGGTTGGAAAGGGTATCATGGAAGGCAACTGTGTTTCACTTACCAGAATACTACGTTCAGCTAAATTAAGTTTAATACA
ATTTTTTAGTAAAATGAAGAAATGGATGGACATGTCAAATCTACCACAAGAATTTCGTGAACGTATAGAAAGGCTAGAGAGAAATTTTGA
GGTGTCTACTGTAATATTCAAAAAATATGAGCCAATTTTTTTAGATATATTTCAAAATCCATATGAAGAACCACCAAAGTTACCACGAAG
CCGGAAGCAGAGGAGGATTCCTTGCAGTGTTAAGGATCTGTTTAATTTCTGTTGGACACTTTTTGTTTATACTAAGGGTAATTTTCGGAT
GATTGGGGATGACTTAGTAAACTCTTATCATTTACTTCTATGCTGCTTGGATCTGATTTTTGCCAATGCGATTATGTGCCCAAATAGACA
AGACTTGCTAAATCCATCATTTAAAGGTTTACCATCTGATTTTCATACTGCTGACTTTACGGCTTCTGAAGAGCCACCCTGCATCATTGC
TGTACTGTGTGAACTGCATGATGGACTTCTCGTAGAAGCAAAAGGAATAAAGGAGCACTACTTTAAGCCATATATTTCAAAACTCTTTGA
CAGGAAGATATTAAAAGGAGAATGCCTCCTGGACCTTTCAAGTTTTACTGATAATAGCAAAGCAGTGAATAAGGAGTATGAAGAGTATGT
TCTAACTGTTGGTGATTTTGATGAGAGGATCTTTTTGGGAGCAGACGCAGAAGAGGAAATTGGAACACCTCGAAAGTTCACTCGTGACAC
CCCATTAGGGAAACTGACAGCACAGGCTAATGTGGAGTATAACCTTCAACAGCACTTTGAAAAAAAAAGGTCATTTGCACCTTCTACCCC
ACTGACCGGACGGAGATATTTACGAGAAAAAGAAGCAGTCATTACTCCTGTTGCATCAGCCACCCAAAGTGTGAGCCGGTTACAGAGTAT
TGTGGCTGGTCTGAAAAATGCACCAAGTGACCAACTTATAAATATTTTTGAATCTTGTGTGCGTAATCCTGTGGAAAACATTATGAAAAT
ACTAAAAGGAATAGGAGAGACTTTCTGTCAACACTATACTCAATCAACAGATGAACAGCCAGGATCTCACATAGACTTTGCTGTAAACAG
ACTAAAGCTGGCAGAAATTTTGTATTATAAAATACTAGAGACTGTAATGGTTCAGGAAACACGAAGACTTCATGGAATGGACATGTCAGT
TCTTTTAGAGCAAGATATATTTCATCGTTCCTTGATGGCTTGTTGTTTGGAAATTGTGCTCTTTGCCTATAGCTCACCTCGTACTTTTCC
TTGGATTATTGAAGTTCTCAACTTGCAACCATTTTACTTTTATAAGGTTATTGAGGTGGTGATCCGCTCAGAAGAGGGGCTCTCAAGGGA
CATGGTGAAACACCTAAACAGCATTGAAGAACAGATTTTGGAGAGTTTAGCATGGAGTCACGATTCTGCACTGTGGGAGGCTCTCCAGGT
TTCTGCAAACAAAGTTCCTACCTGTGAAGAACTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACAAATGTTGATCTTTCCACCGTGGA
TAAGGATCAGAGCATTGCACCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTCATCGCAGACAGCCACCAGAACTT
CGCCTTGTTCTTCCAGCTGGTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTCCGACTCCATAACCAGAAGACTGG
CCAGGAAGTGGTGTTTGTTGCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGAAAGATTGAATTTGACTC
TGCCTCTGGCACCTACACTCTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGGAATGTGGCTGATGTGGTCATCAA
GTTCCCTGAGGAAGAAGCTCCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCACCTGTTCCGCGAGCCTGA
GAAGAGGCCCCCCACCGTGGTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTCTTCGCTCTGTGGATCCGGATTGG
TGCCAATGTCTCCAACTTCACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATGCTGGGACTCATGTATGTCTACTG
GACTCAGCTCAACATGTTCCAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCTGGCAATCGGATGCTGGCCCAGCA
GGCAGTCAAGAGGATCGCTGCAGAGCAGAGCAGTAGATTGGCAAAATATAGGACACTACGAACAGCACATTAGTTCCAGAAGAAAGATGG
AAATTCTGAAAACTGAATGTCAAGAAAAGGAGTCAAGAACAATTCACAGTATGAGAAGAAAAATGGAAAAAAAAAACTTTATTTAAAAAA
GAAAAAAGTCCAGATTGTAGTTATACTTTTGCTTGTTTTTCAGTTTCCCCAACACACAGCAGATACCTGGTGAGCTCAGATAGTCTCTTT
CTCTGACACTGTGTAAGAAGCTGTGAATATTCCTAACTTACCCAGATGTTGCTTTTGAAAAGTTGAAATGTGTAATTGTTTTGGAATAAA

>72729_72729_2_RBL1-RPN2_RBL1_chr20_35672489_ENST00000344359_RPN2_chr20_35852281_ENST00000373622_length(amino acids)=873AA_BP=590
MFEDKPHAEGAAVVAAAGEALQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVTHWLACSLYVACRKSIIPTVGKGIMEGNCVSLTRI
LRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKYEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTL
FVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRQDLLNPSFKGLPSDFHTADFTASEEPPCIIAVLCELHDGLLVEAKGIKEHY
FKPYISKLFDRKILKGECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTRDTPLGKLTAQANVEYNLQQHFE
KKRSFAPSTPLTGRRYLREKEAVITPVASATQSVSRLQSIVAGLKNAPSDQLINIFESCVRNPVENIMKILKGIGETFCQHYTQSTDEQP
GSHIDFAVNRLKLAEILYYKILETVMVQETRRLHGMDMSVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIEVV
IRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTCEELRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKG
TFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPI
LWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSNTFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHA

--------------------------------------------------------------
>72729_72729_3_RBL1-RPN2_RBL1_chr20_35672489_ENST00000373664_RPN2_chr20_35852281_ENST00000237530_length(transcript)=2945nt_BP=1837nt
GGGTAGCGCGCCTGGGAGGGAGAAAGAAGTCGGGGGCCGTGGCGCGCAGCCCGCGGGGCCTGAAGGGATGTTCGAGGACAAGCCCCACGC
TGAGGGGGCGGCGGTGGTCGCCGCAGCCGGGGAGGCGCTACAGGCCCTGTGCCAGGAGCTGAACCTGGACGAGGGGAGCGCGGCCGAAGC
CCTGGACGACTTTACTGCCATCCGAGGCAACTACAGCCTAGAGGGAGAAGTTACACACTGGTTGGCATGTTCATTATATGTTGCATGCCG
CAAAAGCATTATTCCCACGGTTGGAAAGGGTATCATGGAAGGCAACTGTGTTTCACTTACCAGAATACTACGTTCAGCTAAATTAAGTTT
AATACAATTTTTTAGTAAAATGAAGAAATGGATGGACATGTCAAATCTACCACAAGAATTTCGTGAACGTATAGAAAGGCTAGAGAGAAA
TTTTGAGGTGTCTACTGTAATATTCAAAAAATATGAGCCAATTTTTTTAGATATATTTCAAAATCCATATGAAGAACCACCAAAGTTACC
ACGAAGCCGGAAGCAGAGGAGGATTCCTTGCAGTGTTAAGGATCTGTTTAATTTCTGTTGGACACTTTTTGTTTATACTAAGGGTAATTT
TCGGATGATTGGGGATGACTTAGTAAACTCTTATCATTTACTTCTATGCTGCTTGGATCTGATTTTTGCCAATGCGATTATGTGCCCAAA
TAGACAAGACTTGCTAAATCCATCATTTAAAGGTTTACCATCTGATTTTCATACTGCTGACTTTACGGCTTCTGAAGAGCCACCCTGCAT
CATTGCTGTACTGTGTGAACTGCATGATGGACTTCTCGTAGAAGCAAAAGGAATAAAGGAGCACTACTTTAAGCCATATATTTCAAAACT
CTTTGACAGGAAGATATTAAAAGGAGAATGCCTCCTGGACCTTTCAAGTTTTACTGATAATAGCAAAGCAGTGAATAAGGAGTATGAAGA
GTATGTTCTAACTGTTGGTGATTTTGATGAGAGGATCTTTTTGGGAGCAGACGCAGAAGAGGAAATTGGAACACCTCGAAAGTTCACTCG
TGACACCCCATTAGGGAAACTGACAGCACAGGCTAATGTGGAGTATAACCTTCAACAGCACTTTGAAAAAAAAAGGTCATTTGCACCTTC
TACCCCACTGACCGGACGGAGATATTTACGAGAAAAAGAAGCAGTCATTACTCCTGTTGCATCAGCCACCCAAAGTGTGAGCCGGTTACA
GAGTATTGTGGCTGGTCTGAAAAATGCACCAAGTGACCAACTTATAAATATTTTTGAATCTTGTGTGCGTAATCCTGTGGAAAACATTAT
GAAAATACTAAAAGGAATAGGAGAGACTTTCTGTCAACACTATACTCAATCAACAGATGAACAGCCAGGATCTCACATAGACTTTGCTGT
AAACAGACTAAAGCTGGCAGAAATTTTGTATTATAAAATACTAGAGACTGTAATGGTTCAGGAAACACGAAGACTTCATGGAATGGACAT
GTCAGTTCTTTTAGAGCAAGATATATTTCATCGTTCCTTGATGGCTTGTTGTTTGGAAATTGTGCTCTTTGCCTATAGCTCACCTCGTAC
TTTTCCTTGGATTATTGAAGTTCTCAACTTGCAACCATTTTACTTTTATAAGGTTATTGAGGTGGTGATCCGCTCAGAAGAGGGGCTCTC
AAGGGACATGGTGAAACACCTAAACAGCATTGAAGAACAGATTTTGGAGAGTTTAGCATGGAGTCACGATTCTGCACTGTGGGAGGCTCT
CCAGGTTTCTGCAAACAAAGTTCCTACCTGTGAAGAACTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACAAATGTTGATCTTTCCAC
CGTGGATAAGGATCAGAGCATTGCACCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTCATCGCAGACAGCCACCA
GAACTTCGCCTTGTTCTTCCAGCTGGTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTCCGACTCCATAACCAGAA
GACTGGCCAGGAAGTGGTGTTTGTTGCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGAAAGATTGAATT
TGACTCTGCCTCTGGCACCTACACTCTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGGAATGTGGCTGATGTGGT
CATCAAGTTCCCTGAGGAAGAAGCTCCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCACCTGTTCCGCGA
GCCTGAGAAGAGGCCCCCCACCGTGGTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTCTTCGCTCTGTGGATCCG
GATTGGTGCCAATGTCTCCAACTTCACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATGCTGGGACTCATGTATGT
CTACTGGACTCAGCTCAACATGTTCCAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCTGGCAATCGGATGCTGGC
CCAGCAGGCAGTCAAGAGAACAGCACATTAGTTCCAGAAGAAAGATGGAAATTCTGAAAACTGAATGTCAAGAAAAGGAGTCAAGAACAA
TTCACAGTATGAGAAGAAAAATGGAAAAAAAAAACTTTATTTAAAAAAGAAAAAAGTCCAGATTGTAGTTATACTTTTGCTTGTTTTTCA
GTTTCCCCAACACACAGCAGATACCTGGTGAGCTCAGATAGTCTCTTTCTCTGACACTGTGTAAGAAGCTGTGAATATTCCTAACTTACC

>72729_72729_3_RBL1-RPN2_RBL1_chr20_35672489_ENST00000373664_RPN2_chr20_35852281_ENST00000237530_length(amino acids)=857AA_BP=590
MFEDKPHAEGAAVVAAAGEALQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVTHWLACSLYVACRKSIIPTVGKGIMEGNCVSLTRI
LRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKYEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTL
FVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRQDLLNPSFKGLPSDFHTADFTASEEPPCIIAVLCELHDGLLVEAKGIKEHY
FKPYISKLFDRKILKGECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTRDTPLGKLTAQANVEYNLQQHFE
KKRSFAPSTPLTGRRYLREKEAVITPVASATQSVSRLQSIVAGLKNAPSDQLINIFESCVRNPVENIMKILKGIGETFCQHYTQSTDEQP
GSHIDFAVNRLKLAEILYYKILETVMVQETRRLHGMDMSVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIEVV
IRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTCEELRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKG
TFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPI
LWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSNTFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHA

--------------------------------------------------------------
>72729_72729_4_RBL1-RPN2_RBL1_chr20_35672489_ENST00000373664_RPN2_chr20_35852281_ENST00000373622_length(transcript)=2993nt_BP=1837nt
GGGTAGCGCGCCTGGGAGGGAGAAAGAAGTCGGGGGCCGTGGCGCGCAGCCCGCGGGGCCTGAAGGGATGTTCGAGGACAAGCCCCACGC
TGAGGGGGCGGCGGTGGTCGCCGCAGCCGGGGAGGCGCTACAGGCCCTGTGCCAGGAGCTGAACCTGGACGAGGGGAGCGCGGCCGAAGC
CCTGGACGACTTTACTGCCATCCGAGGCAACTACAGCCTAGAGGGAGAAGTTACACACTGGTTGGCATGTTCATTATATGTTGCATGCCG
CAAAAGCATTATTCCCACGGTTGGAAAGGGTATCATGGAAGGCAACTGTGTTTCACTTACCAGAATACTACGTTCAGCTAAATTAAGTTT
AATACAATTTTTTAGTAAAATGAAGAAATGGATGGACATGTCAAATCTACCACAAGAATTTCGTGAACGTATAGAAAGGCTAGAGAGAAA
TTTTGAGGTGTCTACTGTAATATTCAAAAAATATGAGCCAATTTTTTTAGATATATTTCAAAATCCATATGAAGAACCACCAAAGTTACC
ACGAAGCCGGAAGCAGAGGAGGATTCCTTGCAGTGTTAAGGATCTGTTTAATTTCTGTTGGACACTTTTTGTTTATACTAAGGGTAATTT
TCGGATGATTGGGGATGACTTAGTAAACTCTTATCATTTACTTCTATGCTGCTTGGATCTGATTTTTGCCAATGCGATTATGTGCCCAAA
TAGACAAGACTTGCTAAATCCATCATTTAAAGGTTTACCATCTGATTTTCATACTGCTGACTTTACGGCTTCTGAAGAGCCACCCTGCAT
CATTGCTGTACTGTGTGAACTGCATGATGGACTTCTCGTAGAAGCAAAAGGAATAAAGGAGCACTACTTTAAGCCATATATTTCAAAACT
CTTTGACAGGAAGATATTAAAAGGAGAATGCCTCCTGGACCTTTCAAGTTTTACTGATAATAGCAAAGCAGTGAATAAGGAGTATGAAGA
GTATGTTCTAACTGTTGGTGATTTTGATGAGAGGATCTTTTTGGGAGCAGACGCAGAAGAGGAAATTGGAACACCTCGAAAGTTCACTCG
TGACACCCCATTAGGGAAACTGACAGCACAGGCTAATGTGGAGTATAACCTTCAACAGCACTTTGAAAAAAAAAGGTCATTTGCACCTTC
TACCCCACTGACCGGACGGAGATATTTACGAGAAAAAGAAGCAGTCATTACTCCTGTTGCATCAGCCACCCAAAGTGTGAGCCGGTTACA
GAGTATTGTGGCTGGTCTGAAAAATGCACCAAGTGACCAACTTATAAATATTTTTGAATCTTGTGTGCGTAATCCTGTGGAAAACATTAT
GAAAATACTAAAAGGAATAGGAGAGACTTTCTGTCAACACTATACTCAATCAACAGATGAACAGCCAGGATCTCACATAGACTTTGCTGT
AAACAGACTAAAGCTGGCAGAAATTTTGTATTATAAAATACTAGAGACTGTAATGGTTCAGGAAACACGAAGACTTCATGGAATGGACAT
GTCAGTTCTTTTAGAGCAAGATATATTTCATCGTTCCTTGATGGCTTGTTGTTTGGAAATTGTGCTCTTTGCCTATAGCTCACCTCGTAC
TTTTCCTTGGATTATTGAAGTTCTCAACTTGCAACCATTTTACTTTTATAAGGTTATTGAGGTGGTGATCCGCTCAGAAGAGGGGCTCTC
AAGGGACATGGTGAAACACCTAAACAGCATTGAAGAACAGATTTTGGAGAGTTTAGCATGGAGTCACGATTCTGCACTGTGGGAGGCTCT
CCAGGTTTCTGCAAACAAAGTTCCTACCTGTGAAGAACTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACAAATGTTGATCTTTCCAC
CGTGGATAAGGATCAGAGCATTGCACCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTCATCGCAGACAGCCACCA
GAACTTCGCCTTGTTCTTCCAGCTGGTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTCCGACTCCATAACCAGAA
GACTGGCCAGGAAGTGGTGTTTGTTGCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGAAAGATTGAATT
TGACTCTGCCTCTGGCACCTACACTCTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGGAATGTGGCTGATGTGGT
CATCAAGTTCCCTGAGGAAGAAGCTCCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCACCTGTTCCGCGA
GCCTGAGAAGAGGCCCCCCACCGTGGTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTCTTCGCTCTGTGGATCCG
GATTGGTGCCAATGTCTCCAACTTCACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATGCTGGGACTCATGTATGT
CTACTGGACTCAGCTCAACATGTTCCAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCTGGCAATCGGATGCTGGC
CCAGCAGGCAGTCAAGAGGATCGCTGCAGAGCAGAGCAGTAGATTGGCAAAATATAGGACACTACGAACAGCACATTAGTTCCAGAAGAA
AGATGGAAATTCTGAAAACTGAATGTCAAGAAAAGGAGTCAAGAACAATTCACAGTATGAGAAGAAAAATGGAAAAAAAAAACTTTATTT
AAAAAAGAAAAAAGTCCAGATTGTAGTTATACTTTTGCTTGTTTTTCAGTTTCCCCAACACACAGCAGATACCTGGTGAGCTCAGATAGT
CTCTTTCTCTGACACTGTGTAAGAAGCTGTGAATATTCCTAACTTACCCAGATGTTGCTTTTGAAAAGTTGAAATGTGTAATTGTTTTGG

>72729_72729_4_RBL1-RPN2_RBL1_chr20_35672489_ENST00000373664_RPN2_chr20_35852281_ENST00000373622_length(amino acids)=873AA_BP=590
MFEDKPHAEGAAVVAAAGEALQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVTHWLACSLYVACRKSIIPTVGKGIMEGNCVSLTRI
LRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKYEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTL
FVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRQDLLNPSFKGLPSDFHTADFTASEEPPCIIAVLCELHDGLLVEAKGIKEHY
FKPYISKLFDRKILKGECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTRDTPLGKLTAQANVEYNLQQHFE
KKRSFAPSTPLTGRRYLREKEAVITPVASATQSVSRLQSIVAGLKNAPSDQLINIFESCVRNPVENIMKILKGIGETFCQHYTQSTDEQP
GSHIDFAVNRLKLAEILYYKILETVMVQETRRLHGMDMSVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIEVV
IRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTCEELRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKG
TFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPI
LWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSNTFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RBL1-RPN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RBL1-RPN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RBL1-RPN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource