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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RBM10-AGPAT1 (FusionGDB2 ID:72737)

Fusion Gene Summary for RBM10-AGPAT1

Fusion gene summary

Fusion gene information	Fusion gene name: RBM10-AGPAT1
	Fusion gene ID: 72737
		Hgene	Tgene
	Gene symbol	RBM10	AGPAT1
	Gene ID	8241	10554
	Gene name	RNA binding motif protein 10	1-acylglycerol-3-phosphate O-acyltransferase 1
	Synonyms	DXS8237E\|GPATC9\|GPATCH9\|S1-1\|TARPS\|ZRANB5	1-AGPAT1\|G15\|LPAAT-alpha\|LPAATA
	Cytomap	Xp11.3	6p21.32
	Type of gene	protein-coding	protein-coding
	Description	RNA-binding protein 10RNA-binding protein S1-1epididymis secretory sperm binding proteing patch domain-containing protein 9	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha1-AGP acyltransferase 11-AGPAT 11-acylglycerol-3-phosphate O-acyltransferase 1 (acetoacetly Coenzyme A thiolase)1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase,
	Modification date	20200313	20200320
	UniProtAcc	.	Q99943
	Ensembl transtripts involved in fusion gene	ENST00000329236, ENST00000345781, ENST00000377604, ENST00000478410,	ENST00000336984, ENST00000375104, ENST00000375107, ENST00000395496, ENST00000395497, ENST00000395499, ENST00000490711, ENST00000383294, ENST00000399825, ENST00000399827, ENST00000399829, ENST00000399830, ENST00000399833, ENST00000412465, ENST00000414520, ENST00000414933, ENST00000415173, ENST00000416363, ENST00000417388, ENST00000424030, ENST00000425204, ENST00000425572, ENST00000427763, ENST00000430226, ENST00000430777, ENST00000433376, ENST00000433896, ENST00000434614, ENST00000436149, ENST00000439774, ENST00000440840, ENST00000444369, ENST00000446323, ENST00000446463, ENST00000448196, ENST00000449776, ENST00000451833, ENST00000452393, ENST00000452427, ENST00000454929, ENST00000455898, ENST00000456421, ENST00000456679, ENST00000457923, ENST00000474349, ENST00000474400, ENST00000479245, ENST00000488004, ENST00000490267, ENST00000496883,
Fusion gene scores	* DoF score	17 X 8 X 9=1224	2 X 2 X 1=4
	# samples	18	2
	** MAII score	log2(18/1224*10)=-2.76553474636298 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: RBM10 [Title/Abstract] AND AGPAT1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RBM10(47036093)-AGPAT1(32137012), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across RBM10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AGPAT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BG983393	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+

Top

Fusion Gene ORF analysis for RBM10-AGPAT1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000329236	ENST00000336984	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000329236	ENST00000375104	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000329236	ENST00000375107	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000329236	ENST00000395496	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000329236	ENST00000395497	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000329236	ENST00000395499	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000345781	ENST00000336984	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000345781	ENST00000375104	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000345781	ENST00000375107	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000345781	ENST00000395496	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000345781	ENST00000395497	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000345781	ENST00000395499	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000377604	ENST00000336984	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000377604	ENST00000375104	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000377604	ENST00000375107	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000377604	ENST00000395496	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000377604	ENST00000395497	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000377604	ENST00000395499	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000478410	ENST00000336984	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000478410	ENST00000375104	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000478410	ENST00000375107	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000478410	ENST00000395496	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000478410	ENST00000395497	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-3UTR	ENST00000478410	ENST00000395499	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-5UTR	ENST00000329236	ENST00000490711	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-5UTR	ENST00000345781	ENST00000490711	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-5UTR	ENST00000377604	ENST00000490711	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-5UTR	ENST00000478410	ENST00000490711	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000383294	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000399825	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000399827	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000399829	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000399830	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000399833	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000412465	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000414520	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000414933	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000415173	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000416363	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000417388	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000424030	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000425204	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000425572	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000427763	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000430226	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000430777	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000433376	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000433896	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000434614	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000436149	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000439774	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000440840	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000444369	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000446323	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000446463	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000448196	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000449776	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000451833	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000452393	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000452427	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000454929	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000455898	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000456421	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000456679	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000457923	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000474349	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000474400	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000479245	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000488004	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000490267	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000329236	ENST00000496883	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000383294	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000399825	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000399827	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000399829	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000399830	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000399833	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000412465	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000414520	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000414933	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000415173	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000416363	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000417388	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000424030	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000425204	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000425572	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000427763	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000430226	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000430777	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000433376	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000433896	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000434614	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000436149	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000439774	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000440840	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000444369	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000446323	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000446463	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000448196	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000449776	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000451833	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000452393	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000452427	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000454929	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000455898	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000456421	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000456679	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000457923	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000474349	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000474400	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000479245	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000488004	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000490267	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000345781	ENST00000496883	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000383294	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000399825	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000399827	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000399829	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000399830	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000399833	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000412465	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000414520	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000414933	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000415173	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000416363	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000417388	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000424030	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000425204	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000425572	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000427763	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000430226	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000430777	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000433376	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000433896	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000434614	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000436149	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000439774	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000440840	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000444369	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000446323	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000446463	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000448196	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000449776	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000451833	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000452393	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000452427	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000454929	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000455898	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000456421	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000456679	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000457923	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000474349	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000474400	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000479245	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000488004	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000490267	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000377604	ENST00000496883	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000383294	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000399825	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000399827	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000399829	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000399830	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000399833	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000412465	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000414520	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000414933	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000415173	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000416363	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000417388	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000424030	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000425204	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000425572	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000427763	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000430226	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000430777	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000433376	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000433896	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000434614	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000436149	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000439774	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000440840	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000444369	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000446323	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000446463	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000448196	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000449776	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000451833	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000452393	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000452427	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000454929	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000455898	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000456421	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000456679	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000457923	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000474349	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000474400	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000479245	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000488004	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000490267	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+
intron-intron	ENST00000478410	ENST00000496883	RBM10	chrX	47036093	-	AGPAT1	chr6	32137012	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for RBM10-AGPAT1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RBM10-AGPAT1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:47036093/:32137012)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	AGPAT1 Q99943
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000269\|PubMed:21873652, ECO:0000269\|PubMed:9461603}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for RBM10-AGPAT1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RBM10-AGPAT1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for RBM10-AGPAT1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for RBM10-AGPAT1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source