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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASTN2-PALM2-AKAP2 (FusionGDB2 ID:7275)

Fusion Gene Summary for ASTN2-PALM2-AKAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ASTN2-PALM2-AKAP2
Fusion gene ID: 7275
HgeneTgene
Gene symbol

ASTN2

PALM2-AKAP2

Gene ID

23245

445815

Gene nameastrotactin 2PALM2 and AKAP2 fusion
SynonymsbA67K19.1AKAP-2|AKAP-KL|AKAP2|AKAPKL|MISP2|PALM2|PALM2-AKAP2|PRKA2
Cytomap

9q33.1

9q31.3

Type of geneprotein-codingprotein-coding
Descriptionastrotactin-2A-kinase anchor protein 2PALM2-AKAP2 proteinparalemmin-2A kinase (PRKA) anchor protein 2A-kinase anchoring protein 2PALM2-AKAP2 fusionPALM2-AKAP2 readthroughparalemmin 2protein kinase A anchoring protein 2protein kinase A2
Modification date2020031320200313
UniProtAcc

O75129

.
Ensembl transtripts involved in fusion geneENST00000288520, ENST00000313400, 
ENST00000361209, ENST00000361477, 
ENST00000373996, ENST00000341734, 
ENST00000358637, 		ENST00000302798, 
ENST00000374530, 
Fusion gene scores* DoF score16 X 19 X 6=182418 X 17 X 5=1530
# samples 1919
** MAII scorelog2(19/1824*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1530*10)=-3.00946032924907
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASTN2 [Title/Abstract] AND PALM2-AKAP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASTN2(119380603)-PALM2-AKAP2(112898407), # samples:1
Anticipated loss of major functional domain due to fusion event.ASTN2-PALM2-AKAP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ASTN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PALM2-AKAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A29A-06AASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+


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Fusion Gene ORF analysis for ASTN2-PALM2-AKAP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000288520ENST00000302798ASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+
Frame-shiftENST00000288520ENST00000374530ASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+
Frame-shiftENST00000313400ENST00000302798ASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+
Frame-shiftENST00000313400ENST00000374530ASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+
Frame-shiftENST00000361209ENST00000302798ASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+
Frame-shiftENST00000361209ENST00000374530ASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+
Frame-shiftENST00000361477ENST00000302798ASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+
Frame-shiftENST00000361477ENST00000374530ASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+
Frame-shiftENST00000373996ENST00000302798ASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+
Frame-shiftENST00000373996ENST00000374530ASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+
In-frameENST00000341734ENST00000302798ASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+
In-frameENST00000341734ENST00000374530ASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+
In-frameENST00000358637ENST00000302798ASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+
In-frameENST00000358637ENST00000374530ASTN2chr9

119380603

-PALM2-AKAP2chr9

112898407

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341734ASTN2chr9119380603-ENST00000374530PALM2-AKAP2chr9112898407+74637184933447984
ENST00000341734ASTN2chr9119380603-ENST00000302798PALM2-AKAP2chr9112898407+48217184933408971
ENST00000358637ASTN2chr9119380603-ENST00000374530PALM2-AKAP2chr9112898407+74507054803434984
ENST00000358637ASTN2chr9119380603-ENST00000302798PALM2-AKAP2chr9112898407+48087054803395971

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341734ENST00000374530ASTN2chr9119380603-PALM2-AKAP2chr9112898407+0.0007087150.9992913
ENST00000341734ENST00000302798ASTN2chr9119380603-PALM2-AKAP2chr9112898407+0.0022589140.9977411
ENST00000358637ENST00000374530ASTN2chr9119380603-PALM2-AKAP2chr9112898407+0.0006966620.99930334
ENST00000358637ENST00000302798ASTN2chr9119380603-PALM2-AKAP2chr9112898407+0.0022223760.99777764

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Fusion Genomic Features for ASTN2-PALM2-AKAP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ASTN2chr9119380602-PALM2-AKAP2chr9112898406+6.62E-101
ASTN2chr9119380602-PALM2-AKAP2chr9112898406+6.62E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ASTN2-PALM2-AKAP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:119380603/chr9:112898407)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASTN2

O75129

.
FUNCTION: Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6). {ECO:0000250|UniProtKB:Q80Z10, ECO:0000269|Ref.6}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASTN2chr9:119380603chr9:112898407ENST00000313400-1923510_55011181340.0DomainNote=EGF-like 1
HgeneASTN2chr9:119380603chr9:112898407ENST00000313400-1923651_69511181340.0DomainNote=EGF-like 2
HgeneASTN2chr9:119380603chr9:112898407ENST00000313400-1923699_75111181340.0DomainNote=EGF-like 3
HgeneASTN2chr9:119380603chr9:112898407ENST00000361209-1822510_55010671289.0DomainNote=EGF-like 1
HgeneASTN2chr9:119380603chr9:112898407ENST00000361209-1822651_69510671289.0DomainNote=EGF-like 2
HgeneASTN2chr9:119380603chr9:112898407ENST00000361209-1822699_75110671289.0DomainNote=EGF-like 3
HgeneASTN2chr9:119380603chr9:112898407ENST00000373996-1923510_55011141336.0DomainNote=EGF-like 1
HgeneASTN2chr9:119380603chr9:112898407ENST00000373996-1923651_69511141336.0DomainNote=EGF-like 2
HgeneASTN2chr9:119380603chr9:112898407ENST00000373996-1923699_75111141336.0DomainNote=EGF-like 3
HgeneASTN2chr9:119380603chr9:112898407ENST00000288520-4850_206219441.0Topological domainLumenal
HgeneASTN2chr9:119380603chr9:112898407ENST00000313400-1923228_43411181340.0Topological domainCytoplasmic
HgeneASTN2chr9:119380603chr9:112898407ENST00000313400-192350_20611181340.0Topological domainLumenal
HgeneASTN2chr9:119380603chr9:112898407ENST00000361209-1822228_43410671289.0Topological domainCytoplasmic
HgeneASTN2chr9:119380603chr9:112898407ENST00000361209-182250_20610671289.0Topological domainLumenal
HgeneASTN2chr9:119380603chr9:112898407ENST00000373996-1923228_43411141336.0Topological domainCytoplasmic
HgeneASTN2chr9:119380603chr9:112898407ENST00000373996-192350_20611141336.0Topological domainLumenal
HgeneASTN2chr9:119380603chr9:112898407ENST00000313400-1923207_22711181340.0TransmembraneHelical
HgeneASTN2chr9:119380603chr9:112898407ENST00000313400-1923435_45511181340.0TransmembraneHelical
HgeneASTN2chr9:119380603chr9:112898407ENST00000361209-1822207_22710671289.0TransmembraneHelical
HgeneASTN2chr9:119380603chr9:112898407ENST00000361209-1822435_45510671289.0TransmembraneHelical
HgeneASTN2chr9:119380603chr9:112898407ENST00000373996-1923207_22711141336.0TransmembraneHelical
HgeneASTN2chr9:119380603chr9:112898407ENST00000373996-1923435_45511141336.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASTN2chr9:119380603chr9:112898407ENST00000288520-481065_1188219441.0DomainNote=Fibronectin type-III
HgeneASTN2chr9:119380603chr9:112898407ENST00000288520-48510_550219441.0DomainNote=EGF-like 1
HgeneASTN2chr9:119380603chr9:112898407ENST00000288520-48651_695219441.0DomainNote=EGF-like 2
HgeneASTN2chr9:119380603chr9:112898407ENST00000288520-48699_751219441.0DomainNote=EGF-like 3
HgeneASTN2chr9:119380603chr9:112898407ENST00000313400-19231065_118811181340.0DomainNote=Fibronectin type-III
HgeneASTN2chr9:119380603chr9:112898407ENST00000341734-491065_1188170396.0DomainNote=Fibronectin type-III
HgeneASTN2chr9:119380603chr9:112898407ENST00000341734-49510_550170396.0DomainNote=EGF-like 1
HgeneASTN2chr9:119380603chr9:112898407ENST00000341734-49651_695170396.0DomainNote=EGF-like 2
HgeneASTN2chr9:119380603chr9:112898407ENST00000341734-49699_751170396.0DomainNote=EGF-like 3
HgeneASTN2chr9:119380603chr9:112898407ENST00000361209-18221065_118810671289.0DomainNote=Fibronectin type-III
HgeneASTN2chr9:119380603chr9:112898407ENST00000361477-18231065_1188170396.0DomainNote=Fibronectin type-III
HgeneASTN2chr9:119380603chr9:112898407ENST00000361477-1823510_550170396.0DomainNote=EGF-like 1
HgeneASTN2chr9:119380603chr9:112898407ENST00000361477-1823651_695170396.0DomainNote=EGF-like 2
HgeneASTN2chr9:119380603chr9:112898407ENST00000361477-1823699_751170396.0DomainNote=EGF-like 3
HgeneASTN2chr9:119380603chr9:112898407ENST00000373996-19231065_118811141336.0DomainNote=Fibronectin type-III
HgeneASTN2chr9:119380603chr9:112898407ENST00000288520-48228_434219441.0Topological domainCytoplasmic
HgeneASTN2chr9:119380603chr9:112898407ENST00000288520-48456_1339219441.0Topological domainLumenal
HgeneASTN2chr9:119380603chr9:112898407ENST00000313400-1923456_133911181340.0Topological domainLumenal
HgeneASTN2chr9:119380603chr9:112898407ENST00000341734-49228_434170396.0Topological domainCytoplasmic
HgeneASTN2chr9:119380603chr9:112898407ENST00000341734-49456_1339170396.0Topological domainLumenal
HgeneASTN2chr9:119380603chr9:112898407ENST00000341734-4950_206170396.0Topological domainLumenal
HgeneASTN2chr9:119380603chr9:112898407ENST00000361209-1822456_133910671289.0Topological domainLumenal
HgeneASTN2chr9:119380603chr9:112898407ENST00000361477-1823228_434170396.0Topological domainCytoplasmic
HgeneASTN2chr9:119380603chr9:112898407ENST00000361477-1823456_1339170396.0Topological domainLumenal
HgeneASTN2chr9:119380603chr9:112898407ENST00000361477-182350_206170396.0Topological domainLumenal
HgeneASTN2chr9:119380603chr9:112898407ENST00000373996-1923456_133911141336.0Topological domainLumenal
HgeneASTN2chr9:119380603chr9:112898407ENST00000288520-48207_227219441.0TransmembraneHelical
HgeneASTN2chr9:119380603chr9:112898407ENST00000288520-48435_455219441.0TransmembraneHelical
HgeneASTN2chr9:119380603chr9:112898407ENST00000341734-49207_227170396.0TransmembraneHelical
HgeneASTN2chr9:119380603chr9:112898407ENST00000341734-49435_455170396.0TransmembraneHelical
HgeneASTN2chr9:119380603chr9:112898407ENST00000361477-1823207_227170396.0TransmembraneHelical
HgeneASTN2chr9:119380603chr9:112898407ENST00000361477-1823435_455170396.0TransmembraneHelical


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Fusion Gene Sequence for ASTN2-PALM2-AKAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7275_7275_1_ASTN2-PALM2-AKAP2_ASTN2_chr9_119380603_ENST00000341734_PALM2-AKAP2_chr9_112898407_ENST00000302798_length(transcript)=4821nt_BP=718nt
GCTTGTCGTGCAGCTGGCCCCAAGCGCGCGGGGCAAGGCGGCCCTGCAGGGGTGAGCTTTCCTCTGAGAACCCGGGGCCTTAGCGACACG
TAATCCAGTTTTCCGTCTCCTTGGTGCAGATGAAGAAACCGACGCCCATGGGCGAAAGGGACCTGCTCAAGTTCACTCAAGACCACAGAG
CTGGGCAGCAAGAAGGAGCTCAAGTCCATGCCCTTCATCACCTACCTCTCAGGTTTGCTGACAGCCCAGATGCTGTCAGATGACCAGCTC
ATTTCAGGTGTGGAGATTCGCTGTGAGGAGAAGGGGCGCTGTCCATCTACCTGTCACCTTTGCCGCCGGCCAGGCAAGGAGCAGCTGAGC
CCCACACCAGTGCTGCTGGAAATCAACCGTGTGGTGCCACTTTATACCCTCATCCAAGACAATGGCACAAAGGAGGCCTTCAAGAGTGCA
CTGATGAGTTCCTACTGGTGCTCAGGGAAAGGGGATGTGATCGATGACTGGTGCAGGTGTGACCTCAGCGCCTTTGATGCCAATGGGCTC
CCCAACTGCAGCCCCCTTCTGCAGCCGGTGCTGCGGCTGTCCCCAACAGTGGAGCCCTCCAGTACTGTGGTCTCCTTGGAGTGGGTGGAT
GTTCAGCCAGCTATTGGGACCAAGGTCTCCGACTATATTCTGCAGCATAAGAAAGTGGATGAATACACAGACACTGACCTGTACACAGAA
GCCTCCCCAGCTTTCTGAGGATGATATCTGGCTAAAAAGCGAGGGAGACAACTATAGTGCCACCCTCCTGGAGCCTGCTGCCAGCTCTCT
TTCCCCAGATCACAAAAACATGGAAATTGAGGTGTCTGTTGCAGAATGTAAAAGTGTTCCTGGAATCACCTCTACCCCACATCCCATGGA
CCATCCCTCCGCTTTCTATTCACCCCCGCATAATGGCCTCCTTACTGATCACCACGAATCCCTGGATAATGATGTTGCCAGAGAGATCCG
CTATCTAGATGAGGTGCTAGAGGCCAACTGCTGTGATTCTGCTGTGGATGGAACGTACAATGGAACATCCTCCCCAGAGCCTGGTGCAGT
GGTTCTGGTGGGCGGCCTAAGCCCCCCTGTCCACGAGGCGACCCAGCCAGAACCCACTGAAAGAACAGCTAGCCGGCAGGCACCTCCTCA
CATCGAGCTCAGTAATAGCAGCCCTGACCCCATGGCAGAGGCAGAAAGAACAAATGGCCATTCCCCCAGCCAGCCTAGAGATGCGCTGGG
GGACAGCCTGCAGGTGCCTGTCAGCCCCAGCTCCACAACCAGCTCACGGTGTTCTTCCCGAGATGGAGAGTTCACTCTCACCACACTGAA
AAAGGAGGCCAAGTTTGAGCTGCGTGCCTTCCATGAGGACAAGAAGCCCTCCAAGCTCTTTGAGGATGACGAGCATGAGAAAGAACAATA
CTGCATTAGAAAAGTGAGGCCTTCAGAGGAGATGCTGGAGCTGGAAAAGGAGAGGAGAGAGCTCATCCGCAGCCAGGCCGTCAAGAAGAA
TCCTGGCATTGCAGCAAAATGGTGGAATCCCCCGCAGGAAAAAACCATCGAGGAGCAGCTGGACGAGGAACATCTGGAGTCGCACAAAAA
GTACAAGGAGCGCAAAGAGAGAAGGGCACAGCAGGAACAGTTGCTGCTGCAGAAGCAGTTACAGCAGCAGCAGCAGCAGCCCCCATCGCA
GCTCTGCACAGCCCCTGCCTCTTCTCATGAACGCGCAAGCATGATTGACAAAGCAAAGGAGGACATTGTCACAGAGCAGATAGATTTCTC
TGCTGCTCGCAAACAATTTCAGCTGATGGAGAATTCCAGGCAAGCGGTGGCCAAGGGCCAGAGTACACCCAGGCTGTTCTCCATCAAGCC
TTTCTACAGGCCTCTGGGGTCAGTCAACTCAGACAAGCCACTGACTAATCCGAGACCACCTTCTGTCGGGGGACCTCCAGAAGACAGTGG
TGCCTCAGCCGCCAAGGGACAGAAATCCCCCGGTGCCCTGGAGACCCCATCGGCAGCAGGAAGCCAGGGCAACACAGCCTCTCAGGGGAA
GGAAGGGCCCTACAGCGAGCCTTCTAAACGTGGGCCCTTATCTAAACTGTGGGCTGAGGATGGAGAATTTACGAGCGCCCGGGCTGTCCT
CACTGTGGTCAAGGATGATGACCATGGGATTTTGGATCAGTTCTCAAGATCTGTCAATGTCTCCTTGACCCAAGAGGAGCTTGACTCTGG
TCTGGACGAATTGTCGGTGAGGTCTCAGGATACCACAGTCCTGGAGACCCTATCCAATGATTTCAGCATGGACAACATCAGTGACAGCGG
GGCATCCAATGAGACAACCAATGCCCTCCAGGAAAATTCACTGGCTGATTTTTCTCTGCCCCAGACACCACAAACTGACAACCCCTCAGA
GGGCCGAGGAGAAGGCGTCTCCAAGTCATTTAGTGATCATGGTTTCTATTCCCCTTCCTCCACGCTGGGGGACTCTCCGTTGGTTGATGA
CCCCTTGGAGTATCAGGCTGGCCTCCTGGTGCAGAATGCCATTCAACAAGCCATAGCCGAGCAGGTGGATAAAGCTGTGTCCAAAACCAG
CAGGGATGGAGCAGAGCAACAGGGACCTGAAGCGACTGTAGAGGAAGCTGAAGCTGCGGCTTTCGGCTCAGAAAAGCCTCAGAGCATGTT
TGAGCCACCTCAGGTGTCTTCTCCTGTTCAAGAGAAAAGGGATGTATTACCAAAGATTCTGCCTGCTGAAGACAGGGCGCTCAGGGAAAG
GGGGCCCCCCCAGCCACTGCCAGCTGTGCAGCCCAGTGGCCCGATTAACATGGAGGAGACCAGGCCCGAAGGAAGCTATTTCAGCAAGTA
CTCGGAGGCAGCTGAGCTGAGAAGCACAGCCTCCCTCCTGGCCACTCAAGAATCTGACGTGATGGTTGGGCCTTTCAAGCTGAGGTCCAG
GAAACAGCGGACTTTGTCCATGATTGAGGAAGAGATCCGAGCAGCTCAGGAAAGGGAAGAGGAGCTGAAGAGGCAGAGACAAGTCTTGCA
GAGTACGCAGAGCCCCAGGACAAAGAATGCCCCATCACTGCCCTCCAGAACATGCTACAAAACTGCTCCAGGGAAAATAGAGAAAGTCAA
ACCTCCTCCATCCCCCACCACTGAAGGCCCCAGCTTGCAGCCTGACTTAGCCCCTGAAGAGGCTGCCGGAACCCAGCGGCCCAAGAATCT
GATGCAGACCCTCATGGAAGACTATGAGACACACAAATCTAAAAGGCGCGAGAGAATGGATGATAGTAGTGTCCTCGAGGCCACACGGGT
TAATCGAAGAAAGAGCGCACTGGCTTTGCGCTGGGAAGCAGGGATCTATGCCAACCAGGAGGAAGAAGACAACGAATAAACTTCCTTCAA
CCCAGGAAGCGTCTTTGGTGCTTGGGAGACCAAGAAACCAAGAAATTAACAACTGAAAGCATTTTAATGGACTATTTATTAAAGTGCAAA
CAAACTCAGCAATCCTTATGTAGACCAGAAGCTGCAATATACAATGATGAAAATGAAACGAAAAGGAAGTCCCCCCATCAGACTCTGGAC
ACCCAGGAATCAAAAGAGAAAGGACTTTTTTGGTGACTCAATCCCAGTGTCTGGTTTGGGGCCAATCTACAATGGATCCAAAAGGACAAA
ACATGTTACAAGCAAATCAACATAGTTGCTGCAGGCGGAACTGAGACCAGCCTCTCTGGGCGATGAAGGACAATGGTGGTAGGGCCACTT
AGAGAGCAGTAGGGCCCAGGCTGGTGCAGCCTACATGGCACAGGATATTTCCCTGCACCAGTTTCCCACCTGTCACTTGCAGCATCAGAG
GGTGTTGCATTAACTCCATTTTCTCCAGCAGCCATAAAATGAATGGCGTTTCTCTCCATATTTGCCCAGAAGAGGCAGTTATGATTCCAC
TTCTCCTACATTTAATTATTTTTAATTGAGAACAACTCATGATCACAATTCATAAAATCCATATTTTAAGACAATAGTTCTTCATGTCAC
AAACACAATCTATTCTACATGAGGAGGCTGAGAAAGGGGAAGAGAAAAACAAACCAAATGGATGATGTTAGCTTTAGGATCGTGTCTGCT
TATAATATTCACTGATCTGCAGTTTATGAGAACACATTTTCACAGTTATGTTTCTTCATAGGAAAACTATATTTAGTGGGCAACAACTAT
TTTTATGATGGGATGGGGGAGTATATACACGTATAGAATCTGTACGCGTTGAACAACTTGGTTCAAGATGGTGGGGGCATTTTTAGAGCG
GCAATAATTGAAAAAAAAGGCGAACTCTGCCTTGGAGAGGTAGATGATAAGAAATAAAAAGGTGTTTATAACTATTTTGTATTATAAAGT
GGGCCTTAGAGATAGGAAGAAGAATGATGGATTCCTTTTGGATCAATCAGAAAGGAAACACGAAAGAAAAGTCAGGAAGGTAGAGAGAGA
AAAAGGGAGGGAAGGAGAAAGAATGGGAATAAAATAAGGAGGTAAGAGATACTATTTTTGCTGAGCAACCAGTGTGTTTCAGGATGATAC
AAAGAAAAATATAGAATAGAAATAAGTGCAGGCTTGGAATCAGCTACAAATCCTAAAGATGGGGTGTGTGTGGATGTGTGTGTGTGTGTG
TGTACACCATTGTGTGTTTGTAAAATGTGTATGTTCATGAGTAAGGGTGTGTGTGTGTGTGTATTAAAATTCCAGAGTGACCGTGGCACT

>7275_7275_1_ASTN2-PALM2-AKAP2_ASTN2_chr9_119380603_ENST00000341734_PALM2-AKAP2_chr9_112898407_ENST00000302798_length(amino acids)=971AA_BP=74
MTGAGVTSAPLMPMGSPTAAPFCSRCCGCPQQWSPPVLWSPWSGWMFSQLLGPRSPTIFCSIRKWMNTQTLTCTQKPPQLSEDDIWLKSE
GDNYSATLLEPAASSLSPDHKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEANCCDSA
VDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSPSSTTS
SRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWNPPQEK
TIEEQLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQFQLMENSRQ
AVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLS
KLWAEDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETTNALQENSL
ADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVE
EAEAAAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSKYSEAAELRSTASLLA
TQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQP

--------------------------------------------------------------
>7275_7275_2_ASTN2-PALM2-AKAP2_ASTN2_chr9_119380603_ENST00000341734_PALM2-AKAP2_chr9_112898407_ENST00000374530_length(transcript)=7463nt_BP=718nt
GCTTGTCGTGCAGCTGGCCCCAAGCGCGCGGGGCAAGGCGGCCCTGCAGGGGTGAGCTTTCCTCTGAGAACCCGGGGCCTTAGCGACACG
TAATCCAGTTTTCCGTCTCCTTGGTGCAGATGAAGAAACCGACGCCCATGGGCGAAAGGGACCTGCTCAAGTTCACTCAAGACCACAGAG
CTGGGCAGCAAGAAGGAGCTCAAGTCCATGCCCTTCATCACCTACCTCTCAGGTTTGCTGACAGCCCAGATGCTGTCAGATGACCAGCTC
ATTTCAGGTGTGGAGATTCGCTGTGAGGAGAAGGGGCGCTGTCCATCTACCTGTCACCTTTGCCGCCGGCCAGGCAAGGAGCAGCTGAGC
CCCACACCAGTGCTGCTGGAAATCAACCGTGTGGTGCCACTTTATACCCTCATCCAAGACAATGGCACAAAGGAGGCCTTCAAGAGTGCA
CTGATGAGTTCCTACTGGTGCTCAGGGAAAGGGGATGTGATCGATGACTGGTGCAGGTGTGACCTCAGCGCCTTTGATGCCAATGGGCTC
CCCAACTGCAGCCCCCTTCTGCAGCCGGTGCTGCGGCTGTCCCCAACAGTGGAGCCCTCCAGTACTGTGGTCTCCTTGGAGTGGGTGGAT
GTTCAGCCAGCTATTGGGACCAAGGTCTCCGACTATATTCTGCAGCATAAGAAAGTGGATGAATACACAGACACTGACCTGTACACAGAA
GCCTCCCCAGCTTTCTGAGGATGATATCTGGCTAAAAAGCGAGGGAGACAACTATAGTGCCACCCTCCTGGAGCCTGCTGCCAGCTCTCT
TTCCCCAGATCACAAAAACATGGAAATTGAGGTGTCTGTTGCAGAATGTAAAAGTGTTCCTGGAATCACCTCTACCCCACATCCCATGGA
CCATCCCTCCGCTTTCTATTCACCCCCGCATAATGGCCTCCTTACTGATCACCACGAATCCCTGGATAATGATGTTGCCAGAGAGATCCG
CTATCTAGATGAGGTGCTAGAGGCCAACTGCTGTGATTCTGCTGTGGATGGAACGTACAATGGAACATCCTCCCCAGAGCCTGGTGCAGT
GGTTCTGGTGGGCGGCCTAAGCCCCCCTGTCCACGAGGCGACCCAGCCAGAACCCACTGAAAGAACAGCTAGCCGGCAGGCACCTCCTCA
CATCGAGCTCAGTAATAGCAGCCCTGACCCCATGGCAGAGGCAGAAAGAACAAATGGCCATTCCCCCAGCCAGCCTAGAGATGCGCTGGG
GGACAGCCTGCAGGTGCCTGTCAGCCCCAGCTCCACAACCAGCTCACGGTGTTCTTCCCGAGATGGAGAGTTCACTCTCACCACACTGAA
AAAGGAGGCCAAGTTTGAGCTGCGTGCCTTCCATGAGGACAAGAAGCCCTCCAAGCTCTTTGAGGATGACGAGCATGAGAAAGAACAATA
CTGCATTAGAAAAGTGAGGCCTTCAGAGGAGATGCTGGAGCTGGAAAAGGAGAGGAGAGAGCTCATCCGCAGCCAGGCCGTCAAGAAGAA
TCCTGGCATTGCAGCAAAATGGTGGAATCCCCCGCAGGAAAAAACCATCGAGGAGCAGCTGGACGAGGAACATCTGGAGTCGCACAAAAA
GTACAAGGAGCGCAAAGAGAGAAGGGCACAGCAGGAACAGTTGCTGCTGCAGAAGCAGTTACAGCAGCAGCAGCAGCAGCCCCCATCGCA
GCTCTGCACAGCCCCTGCCTCTTCTCATGAACGCGCAAGCATGATTGACAAAGCAAAGGAGGACATTGTCACAGAGCAGATAGATTTCTC
TGCTGCTCGCAAACAATTTCAGCTGATGGAGAATTCCAGGCAAGCGGTGGCCAAGGGCCAGAGTACACCCAGGCTGTTCTCCATCAAGCC
TTTCTACAGGCCTCTGGGGTCAGTCAACTCAGACAAGCCACTGACTAATCCGAGACCACCTTCTGTCGGGGGACCTCCAGAAGACAGTGG
TGCCTCAGCCGCCAAGGGACAGAAATCCCCCGGTGCCCTGGAGACCCCATCGGCAGCAGGAAGCCAGGGCAACACAGCCTCTCAGGGGAA
GGAAGGGCCCTACAGCGAGCCTTCTAAACGTGGGCCCTTATCTAAACTGTGGGCTGAGGATGGAGAATTTACGAGCGCCCGGGCTGTCCT
CACTGTGGTCAAGGATGATGACCATGGGATTTTGGATCAGTTCTCAAGATCTGTCAATGTCTCCTTGACCCAAGAGGAGCTTGACTCTGG
TCTGGACGAATTGTCGGTGAGGTCTCAGGATACCACAGTCCTGGAGACCCTATCCAATGATTTCAGCATGGACAACATCAGTGACAGCGG
GGCATCCAATGAGACAACCAATGCCCTCCAGGAAAATTCACTGGCTGATTTTTCTCTGCCCCAGACACCACAAACTGACAACCCCTCAGA
GGGCCGAGGAGAAGGCGTCTCCAAGTCATTTAGTGATCATGGTTTCTATTCCCCTTCCTCCACGCTGGGGGACTCTCCGTTGGTTGATGA
CCCCTTGGAGTATCAGGCTGGCCTCCTGGTGCAGAATGCCATTCAACAAGCCATAGCCGAGCAGGTGGATAAAGCTGTGTCCAAAACCAG
CAGGGATGGAGCAGAGCAACAGGGACCTGAAGCGACTGTAGAGGAAGCTGAAGCTGCGGCTTTCGGCTCAGAAAAGCCTCAGAGCATGTT
TGAGCCACCTCAGGTGTCTTCTCCTGTTCAAGAGAAAAGGGATGTATTACCAAAGATTCTGCCTGCTGAAGACAGGGCGCTCAGGGAAAG
GGGGCCCCCCCAGCCACTGCCAGCTGTGCAGCCCAGTGGCCCGATTAACATGGAGGAGACCAGGCCCGAAGGAAGCTATTTCAGCAAGTA
CTCGGAGGCAGCTGAGCTGAGAAGCACAGCCTCCCTCCTGGCCACTCAAGAATCTGACGTGATGGTTGGGCCTTTCAAGCTGAGGTCCAG
GAAACAGCGGACTTTGTCCATGATTGAGGAAGAGATCCGAGCAGCTCAGGAAAGGGAAGAGGAGCTGAAGAGGCAGAGACAAGTCTTGCA
GAGTACGCAGAGCCCCAGGACAAAGAATGCCCCATCACTGCCCTCCAGAACATGCTACAAAACTGCTCCAGGGAAAATAGAGAAAGTCAA
ACCTCCTCCATCCCCCACCACTGAAGGCCCCAGCTTGCAGCCTGACTTAGCCCCTGAAGAGGCTGCCGGAACCCAGCGGCCCAAGAATCT
GATGCAGACCCTCATGGAAGACTATGAGACACACAAATCTAAAAGGCGCGAGAGAATGGATGATAGTAGTTACACTTCTAAGTTACTGTC
TTGCAAGGTGACTTCCGAGGTCCTCGAGGCCACACGGGTTAATCGAAGAAAGAGCGCACTGGCTTTGCGCTGGGAAGCAGGGATCTATGC
CAACCAGGAGGAAGAAGACAACGAATAAACTTCCTTCAACCCAGGAAGCGTCTTTGGTGCTTGGGAGACCAAGAAACCAAGAAATTAACA
ACTGAAAGCATTTTAATGGACTATTTATTAAAGTGCAAACAAACTCAGCAATCCTTATGTAGACCAGAAGCTGCAATATACAATGATGAA
AATGAAACGAAAAGGAAGTCCCCCCATCAGACTCTGGACACCCAGGAATCAAAAGAGAAAGGACTTTTTTGGTGACTCAATCCCAGTGTC
TGGTTTGGGGCCAATCTACAATGGATCCAAAAGGACAAAACATGTTACAAGCAAATCAACATAGTTGCTGCAGGCGGAACTGAGACCAGC
CTCTCTGGGCGATGAAGGACAATGGTGGTAGGGCCACTTAGAGAGCAGTAGGGCCCAGGCTGGTGCAGCCTACATGGCACAGGATATTTC
CCTGCACCAGTTTCCCACCTGTCACTTGCAGCATCAGAGGGTGTTGCATTAACTCCATTTTCTCCAGCAGCCATAAAATGAATGGCGTTT
CTCTCCATATTTGCCCAGAAGAGGCAGTTATGATTCCACTTCTCCTACATTTAATTATTTTTAATTGAGAACAACTCATGATCACAATTC
ATAAAATCCATATTTTAAGACAATAGTTCTTCATGTCACAAACACAATCTATTCTACATGAGGAGGCTGAGAAAGGGGAAGAGAAAAACA
AACCAAATGGATGATGTTAGCTTTAGGATCGTGTCTGCTTATAATATTCACTGATCTGCAGTTTATGAGAACACATTTTCACAGTTATGT
TTCTTCATAGGAAAACTATATTTAGTGGGCAACAACTATTTTTATGATGGGATGGGGGAGTATATACACGTATAGAATCTGTACGCGTTG
AACAACTTGGTTCAAGATGGTGGGGGCATTTTTAGAGCGGCAATAATTGAAAAAAAAGGCGAACTCTGCCTTGGAGAGGTAGATGATAAG
AAATAAAAAGGTGTTTATAACTATTTTGTATTATAAAGTGGGCCTTAGAGATAGGAAGAAGAATGATGGATTCCTTTTGGATCAATCAGA
AAGGAAACACGAAAGAAAAGTCAGGAAGGTAGAGAGAGAAAAAGGGAGGGAAGGAGAAAGAATGGGAATAAAATAAGGAGGTAAGAGATA
CTATTTTTGCTGAGCAACCAGTGTGTTTCAGGATGATACAAAGAAAAATATAGAATAGAAATAAGTGCAGGCTTGGAATCAGCTACAAAT
CCTAAAGATGGGGTGTGTGTGGATGTGTGTGTGTGTGTGTGTACACCATTGTGTGTTTGTAAAATGTGTATGTTCATGAGTAAGGGTGTG
TGTGTGTGTGTATTAAAATTCCAGAGTGACCGTGGCACTTGGGTGTACAGGTAATTCCTCCAGAGCTGTTTGCTGGCTTCAGGAGTGGAG
TGAGAATTTCTTTTTTATGAAAAGGGATATAAAGGCACCGAGCTGATGCAGTATTTGTAATATTAAGTTGACCTAACAAGGTATTTGCAT
GAGTCACAATTACAAAGTTTTGAGCGGTTTTGTAATTTGACATTTAGGAGAGTCTCCTATTTATTCTCATACTTTACATTCATGCTTAGT
ATACTATAGAGGATGCCAGCTTTAATCTTTCTGTCATTTAAAGCAATATGATAAGGGTATTCAATAATTGGGTGCCCTAAATTTCTGGAT
GAGAAAATTTTCAATTCTGGCCATGAGAAAGAAAAAAAAATAAACAGCCTTCTTTTTTTTTCCTTTGTTTTAAAACTGTGGTTTTTTAAA
AAAGCAATAATTAACTCAGACCTCACTAAAAATCATTTTTGTTTTTATATTGTTATGTCATAAGCTCTATTATGTTATTCTAACAAGTAG
CAATTTCACAAAATTTGTATGTAGATGTTAACGCACATTTCCTTTGCTTCTTTTATTAGACTAGTGTTGACTTTGGGGGGGGACATTTAT
TCACAAATGAGAAGTAGGCACAAAGTAAAAAATGGAACCATCTACTAACAAGGATCCTTTAAAACTGCCAAGGGAGCTCTAACTTGAAGC
CACATCCTACAGATGGCAGCCCAAATAGCACATGGGCAATTGGCACCATCTTTATATGGTTGAGTCTCCTGAATATTTTGAATGAATTCT
CAACAAAATGTGCTAGCCACTGGGGACGCAAAACAAGTAAGATCCCTGTTGCAAGAAATTCATTTTATAGTGAGGGAGGTTGGCATGGAG
ACTAAAATTCTCAGGAAAATGAGATCCGTGTTAGATTAGAAGTCCTGATGTGAAATGGGAGGACTCAGGAAGGAGGATCGTCTTTACCTG
AGGATTTCTAGCCAGAGGTCCCAGATGCCTGGGCTGAGAACCCAGCGATAAGGGGGCGTTCCCAAAGCAGACACAGGGATAAGAACAGAG
GAGGCAGCAGCATTGCACAGCCCCAGGCACAGTGGCAGTTAGGATGGCTGGAGAGTAGGATAGTTCTATGGGTTGCCCAAAAAATGTGAT
GCGCTTCATGTTTTCTCTGACTCATGGATCTGGTAGAGACCATAGACATGATATAGACTAACTTCCCCATTTTTCACAAGAGGAAACCAT
CCTTATGACTTACCTTAAAGTTTTTTGTTCTGTTTTGAAGGAAACCATGTGCTTCATGAAACCTACAGTTGACAAGAGAATGTACAGCTA
AGAGAAAAGCTTAAGAGGCCACACTATTCGCGGAATGGCTTTAGAGGCAGATGAAGTGGTCTTTGACCACAGTTGATTGAACCAGAGCAC
TTATTGCTTAAAGAATAACAGAGTTCTAGAGCTGGGGGTTCTTGGGCCATGCTCCGTGTGTGGATAAGGAAAGAAATACTGTTTCTGGGA
CTCTCCCACAGTCACAAAGCTGTTTTCACTGTGGCCCCTACATCTCTTAACTTTTGCTATTACTCCTATGCTGCCTTCCGGATTACTGCT
GTCTATCTTCTTGCTCCACTCACTGAAGATCCTATTATAATCCCATGAAAATGTAAATTACAGTTTACTTGGGAGAGCCAGATTTTCTCT
GTGCTCTTGAGTTTTTTATTCATTCAAGAAACCTTGGGCCACCGCTTTGTACATAGCACCGTGCTAGGCTCTGGGATCCCAAATGGACCC
TTTTAACTTTCTGAAGATGGGACCGTCCCCTGGAGGAAAGTCATTCCTGCCTAATCCATCGAGAGAAAGAGGCTTACGAAAAACTTTGCC
TCTGATGCTCAGCCCCACCCCCAAATAGCACACAAGCTTGTTAACCCCACCTCTTACAAAATGTTTAGATTCTGTAGGTGTTAAAAGCCT
TTCTGGAAGTATTGCATTCTGCCGTGTTTATAGGTGTTCACTTTCCTCCAGAGCTGATTAACTACTGACATGACTTGGCTTTCTCATCCA
GAAATTATGGAAACAGGGTCTGTCAGTGGCAGGAGGCCGTGCTGTGTTTTACTTGGATGACACAATGCAGTTTACTTGCCTCTTCATACC
CATGCATGCTGCTCACCCTAGACAATGACATATAAGCCGTATATAGATCAATGTCCACATATATATACACACACACATATATATATATAA
AGTGTAACAAGGAACACTAAAACAGTGTTGATTCTTGTCTCTGAAGACAAATAATTAAACCTTTTTTTTCCCAACTAAAGAATGGATTTA
ATTAAACTATGTATTGAAAAAAAAGTAGCCTAAGTGTTAGAGATGGTGAATATATTCCATTTTAGTTAAAGAACAAATTTCCTGAATTTT
AAGCATTCAGTGAGCTGCCAATTTTGATTTTGTGTTGCTCTTTACCCAAATTATTTTTTCTTTGTTTTTCTTTTTTTGGGGGAGGAGGGG
AAAAAAGCAGCAATACTGTGTTTGGAAATTATACTCTGTATCTGGTTTTCCTGTGTATGTTAACCACTTAAATGTTATTATCCTGCTTTG

>7275_7275_2_ASTN2-PALM2-AKAP2_ASTN2_chr9_119380603_ENST00000341734_PALM2-AKAP2_chr9_112898407_ENST00000374530_length(amino acids)=984AA_BP=74
MTGAGVTSAPLMPMGSPTAAPFCSRCCGCPQQWSPPVLWSPWSGWMFSQLLGPRSPTIFCSIRKWMNTQTLTCTQKPPQLSEDDIWLKSE
GDNYSATLLEPAASSLSPDHKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEANCCDSA
VDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSPSSTTS
SRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWNPPQEK
TIEEQLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQFQLMENSRQ
AVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLS
KLWAEDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETTNALQENSL
ADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVE
EAEAAAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSKYSEAAELRSTASLLA
TQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQP

--------------------------------------------------------------
>7275_7275_3_ASTN2-PALM2-AKAP2_ASTN2_chr9_119380603_ENST00000358637_PALM2-AKAP2_chr9_112898407_ENST00000302798_length(transcript)=4808nt_BP=705nt
CTGGCCCCAAGCGCGCGGGGCAAGGCGGCCCTGCAGGGGTGAGCTTTCCTCTGAGAACCCGGGGCCTTAGCGACACGTAATCCAGTTTTC
CGTCTCCTTGGTGCAGATGAAGAAACCGACGCCCATGGGCGAAAGGGACCTGCTCAAGTTCACTCAAGACCACAGAGCTGGGCAGCAAGA
AGGAGCTCAAGTCCATGCCCTTCATCACCTACCTCTCAGGTTTGCTGACAGCCCAGATGCTGTCAGATGACCAGCTCATTTCAGGTGTGG
AGATTCGCTGTGAGGAGAAGGGGCGCTGTCCATCTACCTGTCACCTTTGCCGCCGGCCAGGCAAGGAGCAGCTGAGCCCCACACCAGTGC
TGCTGGAAATCAACCGTGTGGTGCCACTTTATACCCTCATCCAAGACAATGGCACAAAGGAGGCCTTCAAGAGTGCACTGATGAGTTCCT
ACTGGTGCTCAGGGAAAGGGGATGTGATCGATGACTGGTGCAGGTGTGACCTCAGCGCCTTTGATGCCAATGGGCTCCCCAACTGCAGCC
CCCTTCTGCAGCCGGTGCTGCGGCTGTCCCCAACAGTGGAGCCCTCCAGTACTGTGGTCTCCTTGGAGTGGGTGGATGTTCAGCCAGCTA
TTGGGACCAAGGTCTCCGACTATATTCTGCAGCATAAGAAAGTGGATGAATACACAGACACTGACCTGTACACAGAAGCCTCCCCAGCTT
TCTGAGGATGATATCTGGCTAAAAAGCGAGGGAGACAACTATAGTGCCACCCTCCTGGAGCCTGCTGCCAGCTCTCTTTCCCCAGATCAC
AAAAACATGGAAATTGAGGTGTCTGTTGCAGAATGTAAAAGTGTTCCTGGAATCACCTCTACCCCACATCCCATGGACCATCCCTCCGCT
TTCTATTCACCCCCGCATAATGGCCTCCTTACTGATCACCACGAATCCCTGGATAATGATGTTGCCAGAGAGATCCGCTATCTAGATGAG
GTGCTAGAGGCCAACTGCTGTGATTCTGCTGTGGATGGAACGTACAATGGAACATCCTCCCCAGAGCCTGGTGCAGTGGTTCTGGTGGGC
GGCCTAAGCCCCCCTGTCCACGAGGCGACCCAGCCAGAACCCACTGAAAGAACAGCTAGCCGGCAGGCACCTCCTCACATCGAGCTCAGT
AATAGCAGCCCTGACCCCATGGCAGAGGCAGAAAGAACAAATGGCCATTCCCCCAGCCAGCCTAGAGATGCGCTGGGGGACAGCCTGCAG
GTGCCTGTCAGCCCCAGCTCCACAACCAGCTCACGGTGTTCTTCCCGAGATGGAGAGTTCACTCTCACCACACTGAAAAAGGAGGCCAAG
TTTGAGCTGCGTGCCTTCCATGAGGACAAGAAGCCCTCCAAGCTCTTTGAGGATGACGAGCATGAGAAAGAACAATACTGCATTAGAAAA
GTGAGGCCTTCAGAGGAGATGCTGGAGCTGGAAAAGGAGAGGAGAGAGCTCATCCGCAGCCAGGCCGTCAAGAAGAATCCTGGCATTGCA
GCAAAATGGTGGAATCCCCCGCAGGAAAAAACCATCGAGGAGCAGCTGGACGAGGAACATCTGGAGTCGCACAAAAAGTACAAGGAGCGC
AAAGAGAGAAGGGCACAGCAGGAACAGTTGCTGCTGCAGAAGCAGTTACAGCAGCAGCAGCAGCAGCCCCCATCGCAGCTCTGCACAGCC
CCTGCCTCTTCTCATGAACGCGCAAGCATGATTGACAAAGCAAAGGAGGACATTGTCACAGAGCAGATAGATTTCTCTGCTGCTCGCAAA
CAATTTCAGCTGATGGAGAATTCCAGGCAAGCGGTGGCCAAGGGCCAGAGTACACCCAGGCTGTTCTCCATCAAGCCTTTCTACAGGCCT
CTGGGGTCAGTCAACTCAGACAAGCCACTGACTAATCCGAGACCACCTTCTGTCGGGGGACCTCCAGAAGACAGTGGTGCCTCAGCCGCC
AAGGGACAGAAATCCCCCGGTGCCCTGGAGACCCCATCGGCAGCAGGAAGCCAGGGCAACACAGCCTCTCAGGGGAAGGAAGGGCCCTAC
AGCGAGCCTTCTAAACGTGGGCCCTTATCTAAACTGTGGGCTGAGGATGGAGAATTTACGAGCGCCCGGGCTGTCCTCACTGTGGTCAAG
GATGATGACCATGGGATTTTGGATCAGTTCTCAAGATCTGTCAATGTCTCCTTGACCCAAGAGGAGCTTGACTCTGGTCTGGACGAATTG
TCGGTGAGGTCTCAGGATACCACAGTCCTGGAGACCCTATCCAATGATTTCAGCATGGACAACATCAGTGACAGCGGGGCATCCAATGAG
ACAACCAATGCCCTCCAGGAAAATTCACTGGCTGATTTTTCTCTGCCCCAGACACCACAAACTGACAACCCCTCAGAGGGCCGAGGAGAA
GGCGTCTCCAAGTCATTTAGTGATCATGGTTTCTATTCCCCTTCCTCCACGCTGGGGGACTCTCCGTTGGTTGATGACCCCTTGGAGTAT
CAGGCTGGCCTCCTGGTGCAGAATGCCATTCAACAAGCCATAGCCGAGCAGGTGGATAAAGCTGTGTCCAAAACCAGCAGGGATGGAGCA
GAGCAACAGGGACCTGAAGCGACTGTAGAGGAAGCTGAAGCTGCGGCTTTCGGCTCAGAAAAGCCTCAGAGCATGTTTGAGCCACCTCAG
GTGTCTTCTCCTGTTCAAGAGAAAAGGGATGTATTACCAAAGATTCTGCCTGCTGAAGACAGGGCGCTCAGGGAAAGGGGGCCCCCCCAG
CCACTGCCAGCTGTGCAGCCCAGTGGCCCGATTAACATGGAGGAGACCAGGCCCGAAGGAAGCTATTTCAGCAAGTACTCGGAGGCAGCT
GAGCTGAGAAGCACAGCCTCCCTCCTGGCCACTCAAGAATCTGACGTGATGGTTGGGCCTTTCAAGCTGAGGTCCAGGAAACAGCGGACT
TTGTCCATGATTGAGGAAGAGATCCGAGCAGCTCAGGAAAGGGAAGAGGAGCTGAAGAGGCAGAGACAAGTCTTGCAGAGTACGCAGAGC
CCCAGGACAAAGAATGCCCCATCACTGCCCTCCAGAACATGCTACAAAACTGCTCCAGGGAAAATAGAGAAAGTCAAACCTCCTCCATCC
CCCACCACTGAAGGCCCCAGCTTGCAGCCTGACTTAGCCCCTGAAGAGGCTGCCGGAACCCAGCGGCCCAAGAATCTGATGCAGACCCTC
ATGGAAGACTATGAGACACACAAATCTAAAAGGCGCGAGAGAATGGATGATAGTAGTGTCCTCGAGGCCACACGGGTTAATCGAAGAAAG
AGCGCACTGGCTTTGCGCTGGGAAGCAGGGATCTATGCCAACCAGGAGGAAGAAGACAACGAATAAACTTCCTTCAACCCAGGAAGCGTC
TTTGGTGCTTGGGAGACCAAGAAACCAAGAAATTAACAACTGAAAGCATTTTAATGGACTATTTATTAAAGTGCAAACAAACTCAGCAAT
CCTTATGTAGACCAGAAGCTGCAATATACAATGATGAAAATGAAACGAAAAGGAAGTCCCCCCATCAGACTCTGGACACCCAGGAATCAA
AAGAGAAAGGACTTTTTTGGTGACTCAATCCCAGTGTCTGGTTTGGGGCCAATCTACAATGGATCCAAAAGGACAAAACATGTTACAAGC
AAATCAACATAGTTGCTGCAGGCGGAACTGAGACCAGCCTCTCTGGGCGATGAAGGACAATGGTGGTAGGGCCACTTAGAGAGCAGTAGG
GCCCAGGCTGGTGCAGCCTACATGGCACAGGATATTTCCCTGCACCAGTTTCCCACCTGTCACTTGCAGCATCAGAGGGTGTTGCATTAA
CTCCATTTTCTCCAGCAGCCATAAAATGAATGGCGTTTCTCTCCATATTTGCCCAGAAGAGGCAGTTATGATTCCACTTCTCCTACATTT
AATTATTTTTAATTGAGAACAACTCATGATCACAATTCATAAAATCCATATTTTAAGACAATAGTTCTTCATGTCACAAACACAATCTAT
TCTACATGAGGAGGCTGAGAAAGGGGAAGAGAAAAACAAACCAAATGGATGATGTTAGCTTTAGGATCGTGTCTGCTTATAATATTCACT
GATCTGCAGTTTATGAGAACACATTTTCACAGTTATGTTTCTTCATAGGAAAACTATATTTAGTGGGCAACAACTATTTTTATGATGGGA
TGGGGGAGTATATACACGTATAGAATCTGTACGCGTTGAACAACTTGGTTCAAGATGGTGGGGGCATTTTTAGAGCGGCAATAATTGAAA
AAAAAGGCGAACTCTGCCTTGGAGAGGTAGATGATAAGAAATAAAAAGGTGTTTATAACTATTTTGTATTATAAAGTGGGCCTTAGAGAT
AGGAAGAAGAATGATGGATTCCTTTTGGATCAATCAGAAAGGAAACACGAAAGAAAAGTCAGGAAGGTAGAGAGAGAAAAAGGGAGGGAA
GGAGAAAGAATGGGAATAAAATAAGGAGGTAAGAGATACTATTTTTGCTGAGCAACCAGTGTGTTTCAGGATGATACAAAGAAAAATATA
GAATAGAAATAAGTGCAGGCTTGGAATCAGCTACAAATCCTAAAGATGGGGTGTGTGTGGATGTGTGTGTGTGTGTGTGTACACCATTGT
GTGTTTGTAAAATGTGTATGTTCATGAGTAAGGGTGTGTGTGTGTGTGTATTAAAATTCCAGAGTGACCGTGGCACTTGGGTGTACAGGT

>7275_7275_3_ASTN2-PALM2-AKAP2_ASTN2_chr9_119380603_ENST00000358637_PALM2-AKAP2_chr9_112898407_ENST00000302798_length(amino acids)=971AA_BP=74
MTGAGVTSAPLMPMGSPTAAPFCSRCCGCPQQWSPPVLWSPWSGWMFSQLLGPRSPTIFCSIRKWMNTQTLTCTQKPPQLSEDDIWLKSE
GDNYSATLLEPAASSLSPDHKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEANCCDSA
VDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSPSSTTS
SRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWNPPQEK
TIEEQLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQFQLMENSRQ
AVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLS
KLWAEDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETTNALQENSL
ADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVE
EAEAAAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSKYSEAAELRSTASLLA
TQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQP

--------------------------------------------------------------
>7275_7275_4_ASTN2-PALM2-AKAP2_ASTN2_chr9_119380603_ENST00000358637_PALM2-AKAP2_chr9_112898407_ENST00000374530_length(transcript)=7450nt_BP=705nt
CTGGCCCCAAGCGCGCGGGGCAAGGCGGCCCTGCAGGGGTGAGCTTTCCTCTGAGAACCCGGGGCCTTAGCGACACGTAATCCAGTTTTC
CGTCTCCTTGGTGCAGATGAAGAAACCGACGCCCATGGGCGAAAGGGACCTGCTCAAGTTCACTCAAGACCACAGAGCTGGGCAGCAAGA
AGGAGCTCAAGTCCATGCCCTTCATCACCTACCTCTCAGGTTTGCTGACAGCCCAGATGCTGTCAGATGACCAGCTCATTTCAGGTGTGG
AGATTCGCTGTGAGGAGAAGGGGCGCTGTCCATCTACCTGTCACCTTTGCCGCCGGCCAGGCAAGGAGCAGCTGAGCCCCACACCAGTGC
TGCTGGAAATCAACCGTGTGGTGCCACTTTATACCCTCATCCAAGACAATGGCACAAAGGAGGCCTTCAAGAGTGCACTGATGAGTTCCT
ACTGGTGCTCAGGGAAAGGGGATGTGATCGATGACTGGTGCAGGTGTGACCTCAGCGCCTTTGATGCCAATGGGCTCCCCAACTGCAGCC
CCCTTCTGCAGCCGGTGCTGCGGCTGTCCCCAACAGTGGAGCCCTCCAGTACTGTGGTCTCCTTGGAGTGGGTGGATGTTCAGCCAGCTA
TTGGGACCAAGGTCTCCGACTATATTCTGCAGCATAAGAAAGTGGATGAATACACAGACACTGACCTGTACACAGAAGCCTCCCCAGCTT
TCTGAGGATGATATCTGGCTAAAAAGCGAGGGAGACAACTATAGTGCCACCCTCCTGGAGCCTGCTGCCAGCTCTCTTTCCCCAGATCAC
AAAAACATGGAAATTGAGGTGTCTGTTGCAGAATGTAAAAGTGTTCCTGGAATCACCTCTACCCCACATCCCATGGACCATCCCTCCGCT
TTCTATTCACCCCCGCATAATGGCCTCCTTACTGATCACCACGAATCCCTGGATAATGATGTTGCCAGAGAGATCCGCTATCTAGATGAG
GTGCTAGAGGCCAACTGCTGTGATTCTGCTGTGGATGGAACGTACAATGGAACATCCTCCCCAGAGCCTGGTGCAGTGGTTCTGGTGGGC
GGCCTAAGCCCCCCTGTCCACGAGGCGACCCAGCCAGAACCCACTGAAAGAACAGCTAGCCGGCAGGCACCTCCTCACATCGAGCTCAGT
AATAGCAGCCCTGACCCCATGGCAGAGGCAGAAAGAACAAATGGCCATTCCCCCAGCCAGCCTAGAGATGCGCTGGGGGACAGCCTGCAG
GTGCCTGTCAGCCCCAGCTCCACAACCAGCTCACGGTGTTCTTCCCGAGATGGAGAGTTCACTCTCACCACACTGAAAAAGGAGGCCAAG
TTTGAGCTGCGTGCCTTCCATGAGGACAAGAAGCCCTCCAAGCTCTTTGAGGATGACGAGCATGAGAAAGAACAATACTGCATTAGAAAA
GTGAGGCCTTCAGAGGAGATGCTGGAGCTGGAAAAGGAGAGGAGAGAGCTCATCCGCAGCCAGGCCGTCAAGAAGAATCCTGGCATTGCA
GCAAAATGGTGGAATCCCCCGCAGGAAAAAACCATCGAGGAGCAGCTGGACGAGGAACATCTGGAGTCGCACAAAAAGTACAAGGAGCGC
AAAGAGAGAAGGGCACAGCAGGAACAGTTGCTGCTGCAGAAGCAGTTACAGCAGCAGCAGCAGCAGCCCCCATCGCAGCTCTGCACAGCC
CCTGCCTCTTCTCATGAACGCGCAAGCATGATTGACAAAGCAAAGGAGGACATTGTCACAGAGCAGATAGATTTCTCTGCTGCTCGCAAA
CAATTTCAGCTGATGGAGAATTCCAGGCAAGCGGTGGCCAAGGGCCAGAGTACACCCAGGCTGTTCTCCATCAAGCCTTTCTACAGGCCT
CTGGGGTCAGTCAACTCAGACAAGCCACTGACTAATCCGAGACCACCTTCTGTCGGGGGACCTCCAGAAGACAGTGGTGCCTCAGCCGCC
AAGGGACAGAAATCCCCCGGTGCCCTGGAGACCCCATCGGCAGCAGGAAGCCAGGGCAACACAGCCTCTCAGGGGAAGGAAGGGCCCTAC
AGCGAGCCTTCTAAACGTGGGCCCTTATCTAAACTGTGGGCTGAGGATGGAGAATTTACGAGCGCCCGGGCTGTCCTCACTGTGGTCAAG
GATGATGACCATGGGATTTTGGATCAGTTCTCAAGATCTGTCAATGTCTCCTTGACCCAAGAGGAGCTTGACTCTGGTCTGGACGAATTG
TCGGTGAGGTCTCAGGATACCACAGTCCTGGAGACCCTATCCAATGATTTCAGCATGGACAACATCAGTGACAGCGGGGCATCCAATGAG
ACAACCAATGCCCTCCAGGAAAATTCACTGGCTGATTTTTCTCTGCCCCAGACACCACAAACTGACAACCCCTCAGAGGGCCGAGGAGAA
GGCGTCTCCAAGTCATTTAGTGATCATGGTTTCTATTCCCCTTCCTCCACGCTGGGGGACTCTCCGTTGGTTGATGACCCCTTGGAGTAT
CAGGCTGGCCTCCTGGTGCAGAATGCCATTCAACAAGCCATAGCCGAGCAGGTGGATAAAGCTGTGTCCAAAACCAGCAGGGATGGAGCA
GAGCAACAGGGACCTGAAGCGACTGTAGAGGAAGCTGAAGCTGCGGCTTTCGGCTCAGAAAAGCCTCAGAGCATGTTTGAGCCACCTCAG
GTGTCTTCTCCTGTTCAAGAGAAAAGGGATGTATTACCAAAGATTCTGCCTGCTGAAGACAGGGCGCTCAGGGAAAGGGGGCCCCCCCAG
CCACTGCCAGCTGTGCAGCCCAGTGGCCCGATTAACATGGAGGAGACCAGGCCCGAAGGAAGCTATTTCAGCAAGTACTCGGAGGCAGCT
GAGCTGAGAAGCACAGCCTCCCTCCTGGCCACTCAAGAATCTGACGTGATGGTTGGGCCTTTCAAGCTGAGGTCCAGGAAACAGCGGACT
TTGTCCATGATTGAGGAAGAGATCCGAGCAGCTCAGGAAAGGGAAGAGGAGCTGAAGAGGCAGAGACAAGTCTTGCAGAGTACGCAGAGC
CCCAGGACAAAGAATGCCCCATCACTGCCCTCCAGAACATGCTACAAAACTGCTCCAGGGAAAATAGAGAAAGTCAAACCTCCTCCATCC
CCCACCACTGAAGGCCCCAGCTTGCAGCCTGACTTAGCCCCTGAAGAGGCTGCCGGAACCCAGCGGCCCAAGAATCTGATGCAGACCCTC
ATGGAAGACTATGAGACACACAAATCTAAAAGGCGCGAGAGAATGGATGATAGTAGTTACACTTCTAAGTTACTGTCTTGCAAGGTGACT
TCCGAGGTCCTCGAGGCCACACGGGTTAATCGAAGAAAGAGCGCACTGGCTTTGCGCTGGGAAGCAGGGATCTATGCCAACCAGGAGGAA
GAAGACAACGAATAAACTTCCTTCAACCCAGGAAGCGTCTTTGGTGCTTGGGAGACCAAGAAACCAAGAAATTAACAACTGAAAGCATTT
TAATGGACTATTTATTAAAGTGCAAACAAACTCAGCAATCCTTATGTAGACCAGAAGCTGCAATATACAATGATGAAAATGAAACGAAAA
GGAAGTCCCCCCATCAGACTCTGGACACCCAGGAATCAAAAGAGAAAGGACTTTTTTGGTGACTCAATCCCAGTGTCTGGTTTGGGGCCA
ATCTACAATGGATCCAAAAGGACAAAACATGTTACAAGCAAATCAACATAGTTGCTGCAGGCGGAACTGAGACCAGCCTCTCTGGGCGAT
GAAGGACAATGGTGGTAGGGCCACTTAGAGAGCAGTAGGGCCCAGGCTGGTGCAGCCTACATGGCACAGGATATTTCCCTGCACCAGTTT
CCCACCTGTCACTTGCAGCATCAGAGGGTGTTGCATTAACTCCATTTTCTCCAGCAGCCATAAAATGAATGGCGTTTCTCTCCATATTTG
CCCAGAAGAGGCAGTTATGATTCCACTTCTCCTACATTTAATTATTTTTAATTGAGAACAACTCATGATCACAATTCATAAAATCCATAT
TTTAAGACAATAGTTCTTCATGTCACAAACACAATCTATTCTACATGAGGAGGCTGAGAAAGGGGAAGAGAAAAACAAACCAAATGGATG
ATGTTAGCTTTAGGATCGTGTCTGCTTATAATATTCACTGATCTGCAGTTTATGAGAACACATTTTCACAGTTATGTTTCTTCATAGGAA
AACTATATTTAGTGGGCAACAACTATTTTTATGATGGGATGGGGGAGTATATACACGTATAGAATCTGTACGCGTTGAACAACTTGGTTC
AAGATGGTGGGGGCATTTTTAGAGCGGCAATAATTGAAAAAAAAGGCGAACTCTGCCTTGGAGAGGTAGATGATAAGAAATAAAAAGGTG
TTTATAACTATTTTGTATTATAAAGTGGGCCTTAGAGATAGGAAGAAGAATGATGGATTCCTTTTGGATCAATCAGAAAGGAAACACGAA
AGAAAAGTCAGGAAGGTAGAGAGAGAAAAAGGGAGGGAAGGAGAAAGAATGGGAATAAAATAAGGAGGTAAGAGATACTATTTTTGCTGA
GCAACCAGTGTGTTTCAGGATGATACAAAGAAAAATATAGAATAGAAATAAGTGCAGGCTTGGAATCAGCTACAAATCCTAAAGATGGGG
TGTGTGTGGATGTGTGTGTGTGTGTGTGTACACCATTGTGTGTTTGTAAAATGTGTATGTTCATGAGTAAGGGTGTGTGTGTGTGTGTAT
TAAAATTCCAGAGTGACCGTGGCACTTGGGTGTACAGGTAATTCCTCCAGAGCTGTTTGCTGGCTTCAGGAGTGGAGTGAGAATTTCTTT
TTTATGAAAAGGGATATAAAGGCACCGAGCTGATGCAGTATTTGTAATATTAAGTTGACCTAACAAGGTATTTGCATGAGTCACAATTAC
AAAGTTTTGAGCGGTTTTGTAATTTGACATTTAGGAGAGTCTCCTATTTATTCTCATACTTTACATTCATGCTTAGTATACTATAGAGGA
TGCCAGCTTTAATCTTTCTGTCATTTAAAGCAATATGATAAGGGTATTCAATAATTGGGTGCCCTAAATTTCTGGATGAGAAAATTTTCA
ATTCTGGCCATGAGAAAGAAAAAAAAATAAACAGCCTTCTTTTTTTTTCCTTTGTTTTAAAACTGTGGTTTTTTAAAAAAGCAATAATTA
ACTCAGACCTCACTAAAAATCATTTTTGTTTTTATATTGTTATGTCATAAGCTCTATTATGTTATTCTAACAAGTAGCAATTTCACAAAA
TTTGTATGTAGATGTTAACGCACATTTCCTTTGCTTCTTTTATTAGACTAGTGTTGACTTTGGGGGGGGACATTTATTCACAAATGAGAA
GTAGGCACAAAGTAAAAAATGGAACCATCTACTAACAAGGATCCTTTAAAACTGCCAAGGGAGCTCTAACTTGAAGCCACATCCTACAGA
TGGCAGCCCAAATAGCACATGGGCAATTGGCACCATCTTTATATGGTTGAGTCTCCTGAATATTTTGAATGAATTCTCAACAAAATGTGC
TAGCCACTGGGGACGCAAAACAAGTAAGATCCCTGTTGCAAGAAATTCATTTTATAGTGAGGGAGGTTGGCATGGAGACTAAAATTCTCA
GGAAAATGAGATCCGTGTTAGATTAGAAGTCCTGATGTGAAATGGGAGGACTCAGGAAGGAGGATCGTCTTTACCTGAGGATTTCTAGCC
AGAGGTCCCAGATGCCTGGGCTGAGAACCCAGCGATAAGGGGGCGTTCCCAAAGCAGACACAGGGATAAGAACAGAGGAGGCAGCAGCAT
TGCACAGCCCCAGGCACAGTGGCAGTTAGGATGGCTGGAGAGTAGGATAGTTCTATGGGTTGCCCAAAAAATGTGATGCGCTTCATGTTT
TCTCTGACTCATGGATCTGGTAGAGACCATAGACATGATATAGACTAACTTCCCCATTTTTCACAAGAGGAAACCATCCTTATGACTTAC
CTTAAAGTTTTTTGTTCTGTTTTGAAGGAAACCATGTGCTTCATGAAACCTACAGTTGACAAGAGAATGTACAGCTAAGAGAAAAGCTTA
AGAGGCCACACTATTCGCGGAATGGCTTTAGAGGCAGATGAAGTGGTCTTTGACCACAGTTGATTGAACCAGAGCACTTATTGCTTAAAG
AATAACAGAGTTCTAGAGCTGGGGGTTCTTGGGCCATGCTCCGTGTGTGGATAAGGAAAGAAATACTGTTTCTGGGACTCTCCCACAGTC
ACAAAGCTGTTTTCACTGTGGCCCCTACATCTCTTAACTTTTGCTATTACTCCTATGCTGCCTTCCGGATTACTGCTGTCTATCTTCTTG
CTCCACTCACTGAAGATCCTATTATAATCCCATGAAAATGTAAATTACAGTTTACTTGGGAGAGCCAGATTTTCTCTGTGCTCTTGAGTT
TTTTATTCATTCAAGAAACCTTGGGCCACCGCTTTGTACATAGCACCGTGCTAGGCTCTGGGATCCCAAATGGACCCTTTTAACTTTCTG
AAGATGGGACCGTCCCCTGGAGGAAAGTCATTCCTGCCTAATCCATCGAGAGAAAGAGGCTTACGAAAAACTTTGCCTCTGATGCTCAGC
CCCACCCCCAAATAGCACACAAGCTTGTTAACCCCACCTCTTACAAAATGTTTAGATTCTGTAGGTGTTAAAAGCCTTTCTGGAAGTATT
GCATTCTGCCGTGTTTATAGGTGTTCACTTTCCTCCAGAGCTGATTAACTACTGACATGACTTGGCTTTCTCATCCAGAAATTATGGAAA
CAGGGTCTGTCAGTGGCAGGAGGCCGTGCTGTGTTTTACTTGGATGACACAATGCAGTTTACTTGCCTCTTCATACCCATGCATGCTGCT
CACCCTAGACAATGACATATAAGCCGTATATAGATCAATGTCCACATATATATACACACACACATATATATATATAAAGTGTAACAAGGA
ACACTAAAACAGTGTTGATTCTTGTCTCTGAAGACAAATAATTAAACCTTTTTTTTCCCAACTAAAGAATGGATTTAATTAAACTATGTA
TTGAAAAAAAAGTAGCCTAAGTGTTAGAGATGGTGAATATATTCCATTTTAGTTAAAGAACAAATTTCCTGAATTTTAAGCATTCAGTGA
GCTGCCAATTTTGATTTTGTGTTGCTCTTTACCCAAATTATTTTTTCTTTGTTTTTCTTTTTTTGGGGGAGGAGGGGAAAAAAGCAGCAA
TACTGTGTTTGGAAATTATACTCTGTATCTGGTTTTCCTGTGTATGTTAACCACTTAAATGTTATTATCCTGCTTTGGTTTTAGAGTGAT

>7275_7275_4_ASTN2-PALM2-AKAP2_ASTN2_chr9_119380603_ENST00000358637_PALM2-AKAP2_chr9_112898407_ENST00000374530_length(amino acids)=984AA_BP=74
MTGAGVTSAPLMPMGSPTAAPFCSRCCGCPQQWSPPVLWSPWSGWMFSQLLGPRSPTIFCSIRKWMNTQTLTCTQKPPQLSEDDIWLKSE
GDNYSATLLEPAASSLSPDHKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEANCCDSA
VDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSPSSTTS
SRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWNPPQEK
TIEEQLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQFQLMENSRQ
AVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLS
KLWAEDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETTNALQENSL
ADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVE
EAEAAAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSKYSEAAELRSTASLLA
TQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQP

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Fusion Gene PPI Analysis for ASTN2-PALM2-AKAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASTN2-PALM2-AKAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASTN2-PALM2-AKAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource