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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RBM10-TFE3 (FusionGDB2 ID:72752)

Fusion Gene Summary for RBM10-TFE3

check button Fusion gene summary
Fusion gene informationFusion gene name: RBM10-TFE3
Fusion gene ID: 72752
HgeneTgene
Gene symbol

RBM10

TFE3

Gene ID

8241

7030

Gene nameRNA binding motif protein 10transcription factor binding to IGHM enhancer 3
SynonymsDXS8237E|GPATC9|GPATCH9|S1-1|TARPS|ZRANB5RCCP2|RCCX1|TFEA|bHLHe33
Cytomap

Xp11.3

Xp11.23

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein 10RNA-binding protein S1-1epididymis secretory sperm binding proteing patch domain-containing protein 9transcription factor E3class E basic helix-loop-helix protein 33transcription factor E family, member Atranscription factor for IgH enhancertranscription factor for immunoglobulin heavy-chain enhancer 3
Modification date2020031320200327
UniProtAcc.

P19532

Ensembl transtripts involved in fusion geneENST00000329236, ENST00000345781, 
ENST00000377604, ENST00000478410, 
ENST00000487451, ENST00000315869, 
Fusion gene scores* DoF score17 X 8 X 9=122414 X 15 X 6=1260
# samples 1815
** MAII scorelog2(18/1224*10)=-2.76553474636298
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1260*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBM10 [Title/Abstract] AND TFE3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRBM10(47041725)-TFE3(48895639), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RBM10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TFE3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-DZ-6131-01ARBM10chrX

47041725

-TFE3chrX

48895639

-
ChimerDB4KIRPTCGA-DZ-6131-01ARBM10chrX

47041725

+TFE3chrX

48895639

-
ChimerDB4KIRPTCGA-DZ-6131RBM10chrX

47041725

+TFE3chrX

48895639

-
ChimerKB4..RBM10chrX

47041560

+TFE3chrX

47041560

-


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Fusion Gene ORF analysis for RBM10-TFE3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000329236ENST00000487451RBM10chrX

47041725

+TFE3chrX

48895639

-
5CDS-5UTRENST00000345781ENST00000487451RBM10chrX

47041725

+TFE3chrX

48895639

-
5CDS-5UTRENST00000377604ENST00000487451RBM10chrX

47041725

+TFE3chrX

48895639

-
In-frameENST00000329236ENST00000315869RBM10chrX

47041725

+TFE3chrX

48895639

-
In-frameENST00000345781ENST00000315869RBM10chrX

47041725

+TFE3chrX

48895639

-
In-frameENST00000377604ENST00000315869RBM10chrX

47041725

+TFE3chrX

48895639

-
intron-3CDSENST00000478410ENST00000315869RBM10chrX

47041725

+TFE3chrX

48895639

-
intron-5UTRENST00000478410ENST00000487451RBM10chrX

47041725

+TFE3chrX

48895639

-
intron-intronENST00000329236ENST00000315869RBM10chrX

47041560

+TFE3chrX

47041560

-
intron-intronENST00000329236ENST00000487451RBM10chrX

47041560

+TFE3chrX

47041560

-
intron-intronENST00000345781ENST00000315869RBM10chrX

47041560

+TFE3chrX

47041560

-
intron-intronENST00000345781ENST00000487451RBM10chrX

47041560

+TFE3chrX

47041560

-
intron-intronENST00000377604ENST00000315869RBM10chrX

47041560

+TFE3chrX

47041560

-
intron-intronENST00000377604ENST00000487451RBM10chrX

47041560

+TFE3chrX

47041560

-
intron-intronENST00000478410ENST00000315869RBM10chrX

47041560

+TFE3chrX

47041560

-
intron-intronENST00000478410ENST00000487451RBM10chrX

47041560

+TFE3chrX

47041560

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377604RBM10chrX47041725+ENST00000315869TFE3chrX48895639-5067269242436391071
ENST00000329236RBM10chrX47041725+ENST00000315869TFE3chrX48895639-44702095613042993
ENST00000345781RBM10chrX47041725+ENST00000315869TFE3chrX48895639-44262051142998994

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377604ENST00000315869RBM10chrX47041725+TFE3chrX48895639-0.0041573870.99584264
ENST00000329236ENST00000315869RBM10chrX47041725+TFE3chrX48895639-0.0060560230.993944
ENST00000345781ENST00000315869RBM10chrX47041725+TFE3chrX48895639-0.0054628410.9945372

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Fusion Genomic Features for RBM10-TFE3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RBM10-TFE3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:47041725/chrX:48895639)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TFE3

P19532

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:29146937, PubMed:30733432, PubMed:31672913). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:31672913). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:31672913). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent nuclear exclusion promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRBM10chrX:47041725chrX:48895639ENST00000329236+1623113_125572853.0Compositional biasNote=Poly-Glu
HgeneRBM10chrX:47041725chrX:48895639ENST00000329236+162380_87572853.0Compositional biasNote=Poly-Arg
HgeneRBM10chrX:47041725chrX:48895639ENST00000345781+1623113_125573854.0Compositional biasNote=Poly-Glu
HgeneRBM10chrX:47041725chrX:48895639ENST00000345781+162380_87573854.0Compositional biasNote=Poly-Arg
HgeneRBM10chrX:47041725chrX:48895639ENST00000377604+1724113_125650931.0Compositional biasNote=Poly-Glu
HgeneRBM10chrX:47041725chrX:48895639ENST00000377604+1724561_607650931.0Compositional biasNote=Tyr-rich
HgeneRBM10chrX:47041725chrX:48895639ENST00000377604+172480_87650931.0Compositional biasNote=Poly-Arg
HgeneRBM10chrX:47041725chrX:48895639ENST00000329236+1623129_209572853.0DomainRRM 1
HgeneRBM10chrX:47041725chrX:48895639ENST00000329236+1623300_384572853.0DomainRRM 2
HgeneRBM10chrX:47041725chrX:48895639ENST00000345781+1623129_209573854.0DomainRRM 1
HgeneRBM10chrX:47041725chrX:48895639ENST00000345781+1623300_384573854.0DomainRRM 2
HgeneRBM10chrX:47041725chrX:48895639ENST00000377604+1724129_209650931.0DomainRRM 1
HgeneRBM10chrX:47041725chrX:48895639ENST00000377604+1724300_384650931.0DomainRRM 2
HgeneRBM10chrX:47041725chrX:48895639ENST00000329236+1623212_242572853.0Zinc fingerRanBP2-type
HgeneRBM10chrX:47041725chrX:48895639ENST00000345781+1623212_242573854.0Zinc fingerRanBP2-type
HgeneRBM10chrX:47041725chrX:48895639ENST00000377604+1724212_242650931.0Zinc fingerRanBP2-type
TgeneTFE3chrX:47041725chrX:48895639ENST00000315869310346_399260576.0DomainbHLH
TgeneTFE3chrX:47041725chrX:48895639ENST00000315869310260_271260576.0RegionStrong transcription activation domain
TgeneTFE3chrX:47041725chrX:48895639ENST00000315869310409_430260576.0RegionNote=Leucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRBM10chrX:47041725chrX:48895639ENST00000329236+1623561_607572853.0Compositional biasNote=Tyr-rich
HgeneRBM10chrX:47041725chrX:48895639ENST00000345781+1623561_607573854.0Compositional biasNote=Tyr-rich
HgeneRBM10chrX:47041725chrX:48895639ENST00000329236+1623858_904572853.0DomainG-patch
HgeneRBM10chrX:47041725chrX:48895639ENST00000345781+1623858_904573854.0DomainG-patch
HgeneRBM10chrX:47041725chrX:48895639ENST00000377604+1724858_904650931.0DomainG-patch
HgeneRBM10chrX:47041725chrX:48895639ENST00000329236+1623759_784572853.0Zinc fingerC2H2-type%3B atypical
HgeneRBM10chrX:47041725chrX:48895639ENST00000345781+1623759_784573854.0Zinc fingerC2H2-type%3B atypical
HgeneRBM10chrX:47041725chrX:48895639ENST00000377604+1724759_784650931.0Zinc fingerC2H2-type%3B atypical


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Fusion Gene Sequence for RBM10-TFE3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72752_72752_1_RBM10-TFE3_RBM10_chrX_47041725_ENST00000329236_TFE3_chrX_48895639_ENST00000315869_length(transcript)=4470nt_BP=2095nt
GGTGGTCGGAGCGCCGACTCCCTTCTCGTCGTCGCCATTTTGAGCTGGTGACTGTGGCCGGCTGGGAGTAGGCGGCAGTGAGTTTCCCTG
GGAGGGCAGCGCGCTTGGCGCTTCTCCCCTCCCCCCGATCTGCCTCCAGTCTCGGACTTGGTTGTTGCGCGCTCCGGCTCCGGCTGAGCT
GGGAGAGTTGGAGGAGGTGGCGGCGGGCAGAGGTGATGTCTGGGAGCCCTTCCTTGACAGCCCGGGCCGAGAAGAGTCCCTGCAGGAAGC
ATCACCCAGGCTGGCAGATCATGGTAGCAGCAGCGGGGGTGGCTGGGAAGTGAAACGGAGCCAGCGGCTGAGGAGGGGCCCCAGCAGCCC
CCGAAGGCCCTATCAGGACATGGAGTATGAAAGACGTGGTGGTCGTGGTGACAGGACTGGCCGCTATGGAGCCACTGACCGCTCGCAGGA
TGATGGTGGGGAGAACCGCAGCCGAGACCACGACTACCGGGACATGGACTACCGTTCATATCCTCGCGAGTATGGCAGCCAGGAGGGCAA
GCATGACTATGACGACTCATCTGAGGAGCAGAGTGCGGAGATCCGTGGCCAGCTGCAGTCGCACGGCGTGCAAGCACGGGAGGTTCGGCT
GATGCGGAACAAATCTTCAGGTCAGAGCCGGGGCTTCGCCTTCGTCGAGTTTAGTCACTTGCAGGACGCTACACGATGGATGGAAGCCAA
TCAGCACTCCCTCAACATCCTGGGCCAGAAGGTGTCGATGCACTACAGTGACCCCAAGCCCAAGATCAATGAGGACTGGCTGTGCAATAA
GTGTGGCGTCCAGAACTTCAAACGCCGAGAGAAGTGCTTCAAATGTGGCGTGCCCAAGTCAGAGGCAGAGCAGAAGCTGCCCCTCGGCAC
GAGGCTGGATCAGCAGACACTGCCACTGGGTGGCCGGGAGCTGAGCCAGGGCCTGCTTCCCCTGCCGCAGCCCTACCAGGCCCAGGGAGT
CCTGGCCTCCCAAGCCCTGTCACAGGGCTCGGAGCCAAGCTCAGAGAACGCCAATGACACCATCATTTTGCGCAACCTGAACCCACACAG
CACCATGGATTCCATCCTGGGGGCCCTGGCACCCTACGCGGTGCTGTCCTCCTCCAACGTGCGCGTCATAAAGGACAAGCAGACCCAACT
GAACCGCGGCTTTGCCTTCATCCAGCTCTCCACCATCGAGGCAGCCCAGCTGCTGCAGATCCTGCAGGCCCTGCACCCACCACTCACTAT
CGACGGCAAGACCATCAATGTTGAGTTTGCCAAGGGTTCTAAGAGGGACATGGCCTCCAATGAAGGCAGTCGCATCAGTGCTGCCTCTGT
GGCCAGCACTGCCATTGCTGCGGCCCAGTGGGCCATCTCACAGGCCTCCCAAGGTGGGGAGGGTACCTGGGCCACCTCCGAGGAGCCGCC
GGTCGACTACAGCTACTACCAACAGGATGAGGGCTATGGCAACAGCCAGGGCACAGAGTCTTCCCTCTATGCCCATGGCTACCTCAAGGG
CACCAAGGGCCCTGGCATCACTGGAACCAAAGGGGATCCCACTGGAGCAGGTCCCGAGGCCTCCCTAGAGCCTGGGGCCGACTCTGTGTC
GATGCAGGCTTTCTCTCGCGCCCAGCCTGGTGCTGCTCCTGGCATCTACCAACAATCAGCCGAGGCGAGCAGTAGCCAGGGCACTGCTGC
CAACAGCCAGTCGTATACCATCATGTCACCCGCTGTGCTCAAATCTGAGCTCCAGAGCCCTACCCATCCTAGTTCTGCTCTCCCACCGGC
TACCAGCCCCACTGCCCAGGAATCCTACAGCCAGTACCCTGTTCCCGACGTCTCTACCTACCAGTACGATGAGACCTCCGGCTACTACTA
TGACCCCCAGACCGGCCTCTACTATGACCCCAACTCCCAGTATTACTACAATGCTCAGAGCCAGCAGTACCTGTACTGGGATGGGGAGAG
GCGGACCTATGTTCCCGCCCTGGAGCAGTCGGCCGACGGACATAAGGAGACAGGGGCACCCTCGAAGGAGGGCAAAGAGAAGAAGGAGAA
GCACAAGACCAAGACAGCTCAACAGATTGATGATGTCATTGATGAGATCATCAGCCTGGAGTCCAGTTACAATGATGAAATGCTCAGCTA
TCTGCCCGGAGGCACCACAGGACTGCAGCTCCCCAGCACGCTGCCTGTGTCAGGGAATCTGCTTGATGTGTACAGTAGTCAAGGCGTGGC
CACACCAGCCATCACTGTCAGCAACTCCTGCCCAGCTGAGCTGCCCAACATCAAACGGGAGATCTCTGAGACCGAGGCAAAGGCCCTTTT
GAAGGAACGGCAGAAGAAAGACAATCACAACCTAATTGAGCGTCGCAGGCGATTCAACATTAACGACAGGATCAAGGAACTGGGCACTCT
CATCCCTAAGTCCAGTGACCCGGAGATGCGCTGGAACAAGGGCACCATCCTGAAGGCCTCTGTGGATTATATCCGCAAGCTGCAGAAGGA
GCAGCAGCGCTCCAAAGACCTGGAGAGCCGGCAGCGATCCCTGGAGCAGGCCAACCGCAGCCTGCAGCTCCGAATTCAGGAACTAGAACT
GCAGGCCCAGATCCATGGCCTGCCAGTACCTCCCACTCCAGGGCTGCTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCAAGCCAGA
GCAGCTGGACATTGAGGAGGAGGGCAGGCCAGGCGCAGCAACGTTCCATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATCAGCAGCC
CCCTGCACCGCCCTCAGATGCCCTTCTGGACCTGCACTTTCCCAGCGACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGGGGCTGGA
GGACATTCTGATGGAGGAGGAGGAGGGGGTGGTGGGAGGACTGTCGGGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATCCCCTGCT
CTCTTCAGTGTCCCCTGCTGTCTCCAAGGCCAGCAGCCGCCGCAGCAGCTTCAGCATGGAAGAGGAGTCCTGATCAGGCCTCACCCCTCC
CCTGGGACTTTCCCACCCAGGAAAGGAGGACCAGTCAGGATGAGGCCCCGCCTTTTCCCCCACCCTCCCATGAGACTGCCCTGCCCAGGT
ATCCTGGGGGAAGAGGAGATGTGATCAGGCCCCACCCCTGTAATCAGGCAAGGAGGAGGAGTCAGATGAGGCCCTGCACCTTCCCCAAAG
GAACCGCCCAGTGCAGGTATTTCAGAAGGAGAAGGCTGGAGAAGGACATGAGATCAGGGCCTGCCCCCTGGGGATCACAGCCTCACCCCT
GCCCCTGTGGGACTCATCCTTGCCCAGGTGAGGGAAGGAGACAGGATGAGGTCTCGACCCTGTCCCCTAGGGACTGTCCTAGCCAGGTCT
CCTGGGAAAGGGAGATGTCAGGATGTTGCTCCATCCTTTGTCTTGGAACCACCAGTCTAGTCCGTCCTGGCACAGAAGAGGAGTCAAGTA
ATGGAGGTCCCAGCCCTGGGGGTTTAAGCTCTGCCCCTTCCCCATGAACCCTGCCCTGCTCTGCCCAGGCAAGGAACAGAAGTGAGGATG
AGACCCAGCCCCTTCCCCTGGGAACTCTCCTGGCCTTCTAGGAATGGAGGAGCCAGGCCCCACCCCTTCCCTATAGGAACAGCCCAGCAC
AGGTATTTCAGGTGTGAAAGAATCAGTAGGACCAGGCCACCGCTAGTGCTTGTGGAGATCACAGCCCCACCCTTGTCCCTCAGCAACATC
CCATCTAAGCATTCCACACTGCAGGGAGGAGTGGTACTTAAGCTCCCCTGCCTTAACCTGGGACCAACCTGACCTAACCTAGGAGGGCTC
TGAGCCAACCTTGCTCTTGGGGAAGGGGACAGATTATGAAATTTCATGGATGAATTTTCCAGACCTATATCTGGAGTGAGAGGCCCCCAC
CCTTGGGCAGAGTCCTGCCTTCTTCCTTGAGGGGCAGTTTGGGAAGGTGATGGGTATTAGTGGGGGACTGAGTTCAGGTTACCAGAACCA
GTACCTCAGTATTCTTTTTCAACATGTAGGGCAAGAGGATGAAGGAAGGGGCTATCCTGGGACCTCCCCAGCCCAGGAAAAACTGGAAGC
CTTCCCCCAGCAAGGCAGAAGCTTGGAGGAGGGTTGTAAAAGCATATTGTACCCCCTCATTTGTTTATCTGATTTTTTTATTGCTCCGCA
TACTGAGAATCTAGGCCACCCCAACCTCTGTTCCCCACCCAGTTCTTCATTTGGAGGAATCACCCCATTTCAGAGTTATCAAGAGACACT
CCCCCCTCCATTCCCACCCCTCATACCTACACCCAAGGTTGTCAGCTTTGGATTGCTGGGGCCAGGCCCCATGGAGGGTATACTGAGGGG

>72752_72752_1_RBM10-TFE3_RBM10_chrX_47041725_ENST00000329236_TFE3_chrX_48895639_ENST00000315869_length(amino acids)=993AA_BP=661
MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS
QRLRRGPSSPRRPYQDMEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYRDMDYRSYPREYGSQEGKHDYDDSSEEQSAEIRGQLQS
HGVQAREVRLMRNKSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWLCNKCGVQNFKRREKCFKCGVPKS
EAEQKLPLGTRLDQQTLPLGGRELSQGLLPLPQPYQAQGVLASQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAVLSSSNV
RVIKDKQTQLNRGFAFIQLSTIEAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMASNEGSRISAASVASTAIAAAQWAISQASQGGE
GTWATSEEPPVDYSYYQQDEGYGNSQGTESSLYAHGYLKGTKGPGITGTKGDPTGAGPEASLEPGADSVSMQAFSRAQPGAAPGIYQQSA
EASSSQGTAANSQSYTIMSPAVLKSELQSPTHPSSALPPATSPTAQESYSQYPVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQS
QQYLYWDGERRTYVPALEQSADGHKETGAPSKEGKEKKEKHKTKTAQQIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNL
LDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKAS
VDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGG
PAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSME

--------------------------------------------------------------
>72752_72752_2_RBM10-TFE3_RBM10_chrX_47041725_ENST00000345781_TFE3_chrX_48895639_ENST00000315869_length(transcript)=4426nt_BP=2051nt
GTGACTGTGGCCGGCTGGGAGTAGGCGGCAGTGAGTTTCCCTGGGAGGGCAGCGCGCTTGGCGCTTCTCCCCTCCCCCCGATCTGCCTCC
AGTCTCGGACTTGGTTGTTGCGCGCTCCGGCTCCGGCTGAGCTGGGAGAGTTGGAGGAGGTGGCGGCGGGCAGAGGTGATGTCTGGGAGC
CCTTCCTTGACAGCCCGGGCCGAGAAGAGTCCCTGCAGGAAGCATCACCCAGGCTGGCAGATCATGGTAGCAGCAGCGGGGGTGGCTGGG
AAGTGAAACGGAGCCAGCGGCTGAGGAGGGGCCCCAGCAGCCCCCGAAGGCCCTATCAGGACATGGAGTATGAAAGACGTGGTGGTCGTG
GTGACAGGACTGGCCGCTATGGAGCCACTGACCGCTCGCAGGATGATGGTGGGGAGAACCGCAGCCGAGACCACGACTACCGGGACATGG
ACTACCGTTCATATCCTCGCGAGTATGGCAGCCAGGAGGGCAAGCATGACTATGACGACTCATCTGAGGAGCAGAGTGCGGAGATCCGTG
GCCAGCTGCAGTCGCACGGCGTGCAAGCACGGGAGGTTCGGCTGATGCGGAACAAATCTTCAGGTCAGAGCCGGGGCTTCGCCTTCGTCG
AGTTTAGTCACTTGCAGGACGCTACACGATGGATGGAAGCCAATCAGCACTCCCTCAACATCCTGGGCCAGAAGGTGTCGATGCACTACA
GTGACCCCAAGCCCAAGATCAATGAGGACTGGCTGTGCAATAAGTGTGGCGTCCAGAACTTCAAACGCCGAGAGAAGTGCTTCAAATGTG
GCGTGCCCAAGTCAGAGGCAGAGCAGAAGCTGCCCCTCGGCACGAGGCTGGATCAGCAGACACTGCCACTGGGTGGCCGGGAGCTGAGCC
AGGGCCTGCTTCCCCTGCCGCAGCCCTACCAGGCCCAGGGAGTCCTGGCCTCCCAAGCCCTGTCACAGGGCTCGGAGCCAAGCTCAGAGA
ACGCCAATGACACCATCATTTTGCGCAACCTGAACCCACACAGCACCATGGATTCCATCCTGGGGGCCCTGGCACCCTACGCGGTGCTGT
CCTCCTCCAACGTGCGCGTCATAAAGGACAAGCAGACCCAACTGAACCGCGGCTTTGCCTTCATCCAGCTCTCCACCATCGTGGAGGCAG
CCCAGCTGCTGCAGATCCTGCAGGCCCTGCACCCACCACTCACTATCGACGGCAAGACCATCAATGTTGAGTTTGCCAAGGGTTCTAAGA
GGGACATGGCCTCCAATGAAGGCAGTCGCATCAGTGCTGCCTCTGTGGCCAGCACTGCCATTGCTGCGGCCCAGTGGGCCATCTCACAGG
CCTCCCAAGGTGGGGAGGGTACCTGGGCCACCTCCGAGGAGCCGCCGGTCGACTACAGCTACTACCAACAGGATGAGGGCTATGGCAACA
GCCAGGGCACAGAGTCTTCCCTCTATGCCCATGGCTACCTCAAGGGCACCAAGGGCCCTGGCATCACTGGAACCAAAGGGGATCCCACTG
GAGCAGGTCCCGAGGCCTCCCTAGAGCCTGGGGCCGACTCTGTGTCGATGCAGGCTTTCTCTCGCGCCCAGCCTGGTGCTGCTCCTGGCA
TCTACCAACAATCAGCCGAGGCGAGCAGTAGCCAGGGCACTGCTGCCAACAGCCAGTCGTATACCATCATGTCACCCGCTGTGCTCAAAT
CTGAGCTCCAGAGCCCTACCCATCCTAGTTCTGCTCTCCCACCGGCTACCAGCCCCACTGCCCAGGAATCCTACAGCCAGTACCCTGTTC
CCGACGTCTCTACCTACCAGTACGATGAGACCTCCGGCTACTACTATGACCCCCAGACCGGCCTCTACTATGACCCCAACTCCCAGTATT
ACTACAATGCTCAGAGCCAGCAGTACCTGTACTGGGATGGGGAGAGGCGGACCTATGTTCCCGCCCTGGAGCAGTCGGCCGACGGACATA
AGGAGACAGGGGCACCCTCGAAGGAGGGCAAAGAGAAGAAGGAGAAGCACAAGACCAAGACAGCTCAACAGATTGATGATGTCATTGATG
AGATCATCAGCCTGGAGTCCAGTTACAATGATGAAATGCTCAGCTATCTGCCCGGAGGCACCACAGGACTGCAGCTCCCCAGCACGCTGC
CTGTGTCAGGGAATCTGCTTGATGTGTACAGTAGTCAAGGCGTGGCCACACCAGCCATCACTGTCAGCAACTCCTGCCCAGCTGAGCTGC
CCAACATCAAACGGGAGATCTCTGAGACCGAGGCAAAGGCCCTTTTGAAGGAACGGCAGAAGAAAGACAATCACAACCTAATTGAGCGTC
GCAGGCGATTCAACATTAACGACAGGATCAAGGAACTGGGCACTCTCATCCCTAAGTCCAGTGACCCGGAGATGCGCTGGAACAAGGGCA
CCATCCTGAAGGCCTCTGTGGATTATATCCGCAAGCTGCAGAAGGAGCAGCAGCGCTCCAAAGACCTGGAGAGCCGGCAGCGATCCCTGG
AGCAGGCCAACCGCAGCCTGCAGCTCCGAATTCAGGAACTAGAACTGCAGGCCCAGATCCATGGCCTGCCAGTACCTCCCACTCCAGGGC
TGCTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCAAGCCAGAGCAGCTGGACATTGAGGAGGAGGGCAGGCCAGGCGCAGCAACGT
TCCATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATCAGCAGCCCCCTGCACCGCCCTCAGATGCCCTTCTGGACCTGCACTTTCCCA
GCGACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGGGGCTGGAGGACATTCTGATGGAGGAGGAGGAGGGGGTGGTGGGAGGACTGT
CGGGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATCCCCTGCTCTCTTCAGTGTCCCCTGCTGTCTCCAAGGCCAGCAGCCGCCGCA
GCAGCTTCAGCATGGAAGAGGAGTCCTGATCAGGCCTCACCCCTCCCCTGGGACTTTCCCACCCAGGAAAGGAGGACCAGTCAGGATGAG
GCCCCGCCTTTTCCCCCACCCTCCCATGAGACTGCCCTGCCCAGGTATCCTGGGGGAAGAGGAGATGTGATCAGGCCCCACCCCTGTAAT
CAGGCAAGGAGGAGGAGTCAGATGAGGCCCTGCACCTTCCCCAAAGGAACCGCCCAGTGCAGGTATTTCAGAAGGAGAAGGCTGGAGAAG
GACATGAGATCAGGGCCTGCCCCCTGGGGATCACAGCCTCACCCCTGCCCCTGTGGGACTCATCCTTGCCCAGGTGAGGGAAGGAGACAG
GATGAGGTCTCGACCCTGTCCCCTAGGGACTGTCCTAGCCAGGTCTCCTGGGAAAGGGAGATGTCAGGATGTTGCTCCATCCTTTGTCTT
GGAACCACCAGTCTAGTCCGTCCTGGCACAGAAGAGGAGTCAAGTAATGGAGGTCCCAGCCCTGGGGGTTTAAGCTCTGCCCCTTCCCCA
TGAACCCTGCCCTGCTCTGCCCAGGCAAGGAACAGAAGTGAGGATGAGACCCAGCCCCTTCCCCTGGGAACTCTCCTGGCCTTCTAGGAA
TGGAGGAGCCAGGCCCCACCCCTTCCCTATAGGAACAGCCCAGCACAGGTATTTCAGGTGTGAAAGAATCAGTAGGACCAGGCCACCGCT
AGTGCTTGTGGAGATCACAGCCCCACCCTTGTCCCTCAGCAACATCCCATCTAAGCATTCCACACTGCAGGGAGGAGTGGTACTTAAGCT
CCCCTGCCTTAACCTGGGACCAACCTGACCTAACCTAGGAGGGCTCTGAGCCAACCTTGCTCTTGGGGAAGGGGACAGATTATGAAATTT
CATGGATGAATTTTCCAGACCTATATCTGGAGTGAGAGGCCCCCACCCTTGGGCAGAGTCCTGCCTTCTTCCTTGAGGGGCAGTTTGGGA
AGGTGATGGGTATTAGTGGGGGACTGAGTTCAGGTTACCAGAACCAGTACCTCAGTATTCTTTTTCAACATGTAGGGCAAGAGGATGAAG
GAAGGGGCTATCCTGGGACCTCCCCAGCCCAGGAAAAACTGGAAGCCTTCCCCCAGCAAGGCAGAAGCTTGGAGGAGGGTTGTAAAAGCA
TATTGTACCCCCTCATTTGTTTATCTGATTTTTTTATTGCTCCGCATACTGAGAATCTAGGCCACCCCAACCTCTGTTCCCCACCCAGTT
CTTCATTTGGAGGAATCACCCCATTTCAGAGTTATCAAGAGACACTCCCCCCTCCATTCCCACCCCTCATACCTACACCCAAGGTTGTCA
GCTTTGGATTGCTGGGGCCAGGCCCCATGGAGGGTATACTGAGGGGTCTATAGGTTTGTGATTAAAATAATAAAAGCTAGGCGTGTTTGA

>72752_72752_2_RBM10-TFE3_RBM10_chrX_47041725_ENST00000345781_TFE3_chrX_48895639_ENST00000315869_length(amino acids)=994AA_BP=662
MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS
QRLRRGPSSPRRPYQDMEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYRDMDYRSYPREYGSQEGKHDYDDSSEEQSAEIRGQLQS
HGVQAREVRLMRNKSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWLCNKCGVQNFKRREKCFKCGVPKS
EAEQKLPLGTRLDQQTLPLGGRELSQGLLPLPQPYQAQGVLASQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAVLSSSNV
RVIKDKQTQLNRGFAFIQLSTIVEAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMASNEGSRISAASVASTAIAAAQWAISQASQGG
EGTWATSEEPPVDYSYYQQDEGYGNSQGTESSLYAHGYLKGTKGPGITGTKGDPTGAGPEASLEPGADSVSMQAFSRAQPGAAPGIYQQS
AEASSSQGTAANSQSYTIMSPAVLKSELQSPTHPSSALPPATSPTAQESYSQYPVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQ
SQQYLYWDGERRTYVPALEQSADGHKETGAPSKEGKEKKEKHKTKTAQQIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGN
LLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKA
SVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGG
GPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSM

--------------------------------------------------------------
>72752_72752_3_RBM10-TFE3_RBM10_chrX_47041725_ENST00000377604_TFE3_chrX_48895639_ENST00000315869_length(transcript)=5067nt_BP=2692nt
GCCAACCATTTTCGGCCAGGCTGAGAAATTTCTTATTGATGGGTCTGCTCATTTCCTGCATAGGAAGAAATCGGTGACATTTGGGTGGAT
ACAGTTCCCAGCCAATCGCCCCGAGTTCCCTCGCCCACTGGGGAAAGAGGCAGAGCTTCCGCTAGTCTTTCATCTTCAAAGGAAATCAAG
CTTCTAAAAAGCGGGCCCTGCCGAATTGGCTAATAGCTACTCCTTTTCTCCACTAGGGGAGCGTTCGCAAGGGGTGTGGGGAGGTGGCCA
GCGCTTGCCAATCAGAGGAGGCCAGGGCTGTCCCCTAGCGGGCGGTGACCAATCGCCGGGGCCGGCCAGAGCGCGCTTCCTTAGTAGGTG
GATGGTGGTCGGAGCGCCGACTCCCTTCTCGTCGTCGCCATTTTGAGCTGGTGACTGTGGCCGGCTGGGAGTAGGCGGCAGTGAGTTTCC
CTGGGAGGGCAGCGCGCTTGGCGCTTCTCCCCTCCCCCCGATCTGCCTCCAGTCTCGGACTTGGTTGTTGCGCGCTCCGGCTCCGGCTGA
GCTGGGAGAGTTGGAGGAGGTGGCGGCGGGCAGAGGTGATGTCTGGGAGCCCTTCCTTGACAGCCCGGGCCGAGAAGAGTCCCTGCAGGA
AGCATCACCCAGGCTGGCAGATCATGGTAGCAGCAGCGGGGGTGGCTGGGAAGTGAAACGGAGCCAGCGGCTGAGGAGGGGCCCCAGCAG
CCCCCGAAGGCCCTATCAGGACATGGAGTATGAAAGACGTGGTGGTCGTGGTGACAGGACTGGCCGCTATGGAGCCACTGACCGCTCGCA
GGATGATGGTGGGGAGAACCGCAGCCGAGACCACGACTACCGGGACATGGACTACCGTTCATATCCTCGCGAGTATGGCAGCCAGGAGGG
CAAGCATGACTATGACGACTCATCTGAGGAGCAGAGTGCGGAGGATTCCTACGAGGCCTCCCCGGGCTCCGAGACTCAGCGTAGGCGGCG
GCGGCGGCACAGGCACAGCCCCACCGGCCCGCCAGGCTTCCCCCGAGACGGCGACTATCGGGACCAGGACTATCGGACCGAGCAAGGGGA
GGAGGAGGAGGAGGAGGAGGATGAGGAGGAGGAGGAGAAGGCCAGTAACATCGTCATGCTGAGGATGCTGCCACAGGCAGCCACTGAGGA
TGACATCCGTGGCCAGCTGCAGTCGCACGGCGTGCAAGCACGGGAGGTTCGGCTGATGCGGAACAAATCTTCAGGTCAGAGCCGGGGCTT
CGCCTTCGTCGAGTTTAGTCACTTGCAGGACGCTACACGATGGATGGAAGCCAATCAGCACTCCCTCAACATCCTGGGCCAGAAGGTGTC
GATGCACTACAGTGACCCCAAGCCCAAGATCAATGAGGACTGGCTGTGCAATAAGTGTGGCGTCCAGAACTTCAAACGCCGAGAGAAGTG
CTTCAAATGTGGCGTGCCCAAGTCAGAGGCAGAGCAGAAGCTGCCCCTCGGCACGAGGCTGGATCAGCAGACACTGCCACTGGGTGGCCG
GGAGCTGAGCCAGGGCCTGCTTCCCCTGCCGCAGCCCTACCAGGCCCAGGGAGTCCTGGCCTCCCAAGCCCTGTCACAGGGCTCGGAGCC
AAGCTCAGAGAACGCCAATGACACCATCATTTTGCGCAACCTGAACCCACACAGCACCATGGATTCCATCCTGGGGGCCCTGGCACCCTA
CGCGGTGCTGTCCTCCTCCAACGTGCGCGTCATAAAGGACAAGCAGACCCAACTGAACCGCGGCTTTGCCTTCATCCAGCTCTCCACCAT
CGTGGAGGCAGCCCAGCTGCTGCAGATCCTGCAGGCCCTGCACCCACCACTCACTATCGACGGCAAGACCATCAATGTTGAGTTTGCCAA
GGGTTCTAAGAGGGACATGGCCTCCAATGAAGGCAGTCGCATCAGTGCTGCCTCTGTGGCCAGCACTGCCATTGCTGCGGCCCAGTGGGC
CATCTCACAGGCCTCCCAAGGTGGGGAGGGTACCTGGGCCACCTCCGAGGAGCCGCCGGTCGACTACAGCTACTACCAACAGGATGAGGG
CTATGGCAACAGCCAGGGCACAGAGTCTTCCCTCTATGCCCATGGCTACCTCAAGGGCACCAAGGGCCCTGGCATCACTGGAACCAAAGG
GGATCCCACTGGAGCAGGTCCCGAGGCCTCCCTAGAGCCTGGGGCCGACTCTGTGTCGATGCAGGCTTTCTCTCGCGCCCAGCCTGGTGC
TGCTCCTGGCATCTACCAACAATCAGCCGAGGCGAGCAGTAGCCAGGGCACTGCTGCCAACAGCCAGTCGTATACCATCATGTCACCCGC
TGTGCTCAAATCTGAGCTCCAGAGCCCTACCCATCCTAGTTCTGCTCTCCCACCGGCTACCAGCCCCACTGCCCAGGAATCCTACAGCCA
GTACCCTGTTCCCGACGTCTCTACCTACCAGTACGATGAGACCTCCGGCTACTACTATGACCCCCAGACCGGCCTCTACTATGACCCCAA
CTCCCAGTATTACTACAATGCTCAGAGCCAGCAGTACCTGTACTGGGATGGGGAGAGGCGGACCTATGTTCCCGCCCTGGAGCAGTCGGC
CGACGGACATAAGGAGACAGGGGCACCCTCGAAGGAGGGCAAAGAGAAGAAGGAGAAGCACAAGACCAAGACAGCTCAACAGATTGATGA
TGTCATTGATGAGATCATCAGCCTGGAGTCCAGTTACAATGATGAAATGCTCAGCTATCTGCCCGGAGGCACCACAGGACTGCAGCTCCC
CAGCACGCTGCCTGTGTCAGGGAATCTGCTTGATGTGTACAGTAGTCAAGGCGTGGCCACACCAGCCATCACTGTCAGCAACTCCTGCCC
AGCTGAGCTGCCCAACATCAAACGGGAGATCTCTGAGACCGAGGCAAAGGCCCTTTTGAAGGAACGGCAGAAGAAAGACAATCACAACCT
AATTGAGCGTCGCAGGCGATTCAACATTAACGACAGGATCAAGGAACTGGGCACTCTCATCCCTAAGTCCAGTGACCCGGAGATGCGCTG
GAACAAGGGCACCATCCTGAAGGCCTCTGTGGATTATATCCGCAAGCTGCAGAAGGAGCAGCAGCGCTCCAAAGACCTGGAGAGCCGGCA
GCGATCCCTGGAGCAGGCCAACCGCAGCCTGCAGCTCCGAATTCAGGAACTAGAACTGCAGGCCCAGATCCATGGCCTGCCAGTACCTCC
CACTCCAGGGCTGCTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCAAGCCAGAGCAGCTGGACATTGAGGAGGAGGGCAGGCCAGG
CGCAGCAACGTTCCATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATCAGCAGCCCCCTGCACCGCCCTCAGATGCCCTTCTGGACCT
GCACTTTCCCAGCGACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGGGGCTGGAGGACATTCTGATGGAGGAGGAGGAGGGGGTGGT
GGGAGGACTGTCGGGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATCCCCTGCTCTCTTCAGTGTCCCCTGCTGTCTCCAAGGCCAG
CAGCCGCCGCAGCAGCTTCAGCATGGAAGAGGAGTCCTGATCAGGCCTCACCCCTCCCCTGGGACTTTCCCACCCAGGAAAGGAGGACCA
GTCAGGATGAGGCCCCGCCTTTTCCCCCACCCTCCCATGAGACTGCCCTGCCCAGGTATCCTGGGGGAAGAGGAGATGTGATCAGGCCCC
ACCCCTGTAATCAGGCAAGGAGGAGGAGTCAGATGAGGCCCTGCACCTTCCCCAAAGGAACCGCCCAGTGCAGGTATTTCAGAAGGAGAA
GGCTGGAGAAGGACATGAGATCAGGGCCTGCCCCCTGGGGATCACAGCCTCACCCCTGCCCCTGTGGGACTCATCCTTGCCCAGGTGAGG
GAAGGAGACAGGATGAGGTCTCGACCCTGTCCCCTAGGGACTGTCCTAGCCAGGTCTCCTGGGAAAGGGAGATGTCAGGATGTTGCTCCA
TCCTTTGTCTTGGAACCACCAGTCTAGTCCGTCCTGGCACAGAAGAGGAGTCAAGTAATGGAGGTCCCAGCCCTGGGGGTTTAAGCTCTG
CCCCTTCCCCATGAACCCTGCCCTGCTCTGCCCAGGCAAGGAACAGAAGTGAGGATGAGACCCAGCCCCTTCCCCTGGGAACTCTCCTGG
CCTTCTAGGAATGGAGGAGCCAGGCCCCACCCCTTCCCTATAGGAACAGCCCAGCACAGGTATTTCAGGTGTGAAAGAATCAGTAGGACC
AGGCCACCGCTAGTGCTTGTGGAGATCACAGCCCCACCCTTGTCCCTCAGCAACATCCCATCTAAGCATTCCACACTGCAGGGAGGAGTG
GTACTTAAGCTCCCCTGCCTTAACCTGGGACCAACCTGACCTAACCTAGGAGGGCTCTGAGCCAACCTTGCTCTTGGGGAAGGGGACAGA
TTATGAAATTTCATGGATGAATTTTCCAGACCTATATCTGGAGTGAGAGGCCCCCACCCTTGGGCAGAGTCCTGCCTTCTTCCTTGAGGG
GCAGTTTGGGAAGGTGATGGGTATTAGTGGGGGACTGAGTTCAGGTTACCAGAACCAGTACCTCAGTATTCTTTTTCAACATGTAGGGCA
AGAGGATGAAGGAAGGGGCTATCCTGGGACCTCCCCAGCCCAGGAAAAACTGGAAGCCTTCCCCCAGCAAGGCAGAAGCTTGGAGGAGGG
TTGTAAAAGCATATTGTACCCCCTCATTTGTTTATCTGATTTTTTTATTGCTCCGCATACTGAGAATCTAGGCCACCCCAACCTCTGTTC
CCCACCCAGTTCTTCATTTGGAGGAATCACCCCATTTCAGAGTTATCAAGAGACACTCCCCCCTCCATTCCCACCCCTCATACCTACACC
CAAGGTTGTCAGCTTTGGATTGCTGGGGCCAGGCCCCATGGAGGGTATACTGAGGGGTCTATAGGTTTGTGATTAAAATAATAAAAGCTA

>72752_72752_3_RBM10-TFE3_RBM10_chrX_47041725_ENST00000377604_TFE3_chrX_48895639_ENST00000315869_length(amino acids)=1071AA_BP=215
MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS
QRLRRGPSSPRRPYQDMEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYRDMDYRSYPREYGSQEGKHDYDDSSEEQSAEDSYEASP
GSETQRRRRRRHRHSPTGPPGFPRDGDYRDQDYRTEQGEEEEEEEDEEEEEKASNIVMLRMLPQAATEDDIRGQLQSHGVQAREVRLMRN
KSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWLCNKCGVQNFKRREKCFKCGVPKSEAEQKLPLGTRLD
QQTLPLGGRELSQGLLPLPQPYQAQGVLASQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAVLSSSNVRVIKDKQTQLNRG
FAFIQLSTIVEAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMASNEGSRISAASVASTAIAAAQWAISQASQGGEGTWATSEEPPVD
YSYYQQDEGYGNSQGTESSLYAHGYLKGTKGPGITGTKGDPTGAGPEASLEPGADSVSMQAFSRAQPGAAPGIYQQSAEASSSQGTAANS
QSYTIMSPAVLKSELQSPTHPSSALPPATSPTAQESYSQYPVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQSQQYLYWDGERRT
YVPALEQSADGHKETGAPSKEGKEKKEKHKTKTAQQIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATP
AITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQ
RSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RBM10-TFE3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RBM10-TFE3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RBM10-TFE3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource