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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RBM10-WWP2 (FusionGDB2 ID:72754)

Fusion Gene Summary for RBM10-WWP2

check button Fusion gene summary
Fusion gene informationFusion gene name: RBM10-WWP2
Fusion gene ID: 72754
HgeneTgene
Gene symbol

RBM10

WWP2

Gene ID

8241

11060

Gene nameRNA binding motif protein 10WW domain containing E3 ubiquitin protein ligase 2
SynonymsDXS8237E|GPATC9|GPATCH9|S1-1|TARPS|ZRANB5AIP2|WWp2-like
Cytomap

Xp11.3

16q22.1

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein 10RNA-binding protein S1-1epididymis secretory sperm binding proteing patch domain-containing protein 9NEDD4-like E3 ubiquitin-protein ligase WWP2HECT-type E3 ubiquitin transferase WWP2atrophin-1 interacting protein 2
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000329236, ENST00000345781, 
ENST00000377604, ENST00000478410, 
ENST00000542271, ENST00000544162, 
ENST00000568684, ENST00000356003, 
ENST00000569174, ENST00000359154, 
ENST00000448661, 
Fusion gene scores* DoF score17 X 8 X 9=122413 X 14 X 9=1638
# samples 1816
** MAII scorelog2(18/1224*10)=-2.76553474636298
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1638*10)=-3.35579154675365
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBM10 [Title/Abstract] AND WWP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRBM10(47006897)-WWP2(69967872), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWWP2

GO:0016567

protein ubiquitination

18776082|26280536

TgeneWWP2

GO:0032410

negative regulation of transporter activity

18776082

TgeneWWP2

GO:0034765

regulation of ion transmembrane transport

17289006

TgeneWWP2

GO:0042391

regulation of membrane potential

17289006

TgeneWWP2

GO:0051865

protein autoubiquitination

24105792

TgeneWWP2

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006


check buttonFusion gene breakpoints across RBM10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WWP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA936538RBM10chrX

47006897

+WWP2chr16

69967872

+


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Fusion Gene ORF analysis for RBM10-WWP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000329236ENST00000542271RBM10chrX

47006897

+WWP2chr16

69967872

+
5CDS-3UTRENST00000329236ENST00000544162RBM10chrX

47006897

+WWP2chr16

69967872

+
5CDS-3UTRENST00000329236ENST00000568684RBM10chrX

47006897

+WWP2chr16

69967872

+
5CDS-3UTRENST00000345781ENST00000542271RBM10chrX

47006897

+WWP2chr16

69967872

+
5CDS-3UTRENST00000345781ENST00000544162RBM10chrX

47006897

+WWP2chr16

69967872

+
5CDS-3UTRENST00000345781ENST00000568684RBM10chrX

47006897

+WWP2chr16

69967872

+
5CDS-3UTRENST00000377604ENST00000542271RBM10chrX

47006897

+WWP2chr16

69967872

+
5CDS-3UTRENST00000377604ENST00000544162RBM10chrX

47006897

+WWP2chr16

69967872

+
5CDS-3UTRENST00000377604ENST00000568684RBM10chrX

47006897

+WWP2chr16

69967872

+
5CDS-intronENST00000329236ENST00000356003RBM10chrX

47006897

+WWP2chr16

69967872

+
5CDS-intronENST00000329236ENST00000569174RBM10chrX

47006897

+WWP2chr16

69967872

+
5CDS-intronENST00000345781ENST00000356003RBM10chrX

47006897

+WWP2chr16

69967872

+
5CDS-intronENST00000345781ENST00000569174RBM10chrX

47006897

+WWP2chr16

69967872

+
5CDS-intronENST00000377604ENST00000356003RBM10chrX

47006897

+WWP2chr16

69967872

+
5CDS-intronENST00000377604ENST00000569174RBM10chrX

47006897

+WWP2chr16

69967872

+
In-frameENST00000329236ENST00000359154RBM10chrX

47006897

+WWP2chr16

69967872

+
In-frameENST00000329236ENST00000448661RBM10chrX

47006897

+WWP2chr16

69967872

+
In-frameENST00000345781ENST00000359154RBM10chrX

47006897

+WWP2chr16

69967872

+
In-frameENST00000345781ENST00000448661RBM10chrX

47006897

+WWP2chr16

69967872

+
In-frameENST00000377604ENST00000359154RBM10chrX

47006897

+WWP2chr16

69967872

+
In-frameENST00000377604ENST00000448661RBM10chrX

47006897

+WWP2chr16

69967872

+
intron-3CDSENST00000478410ENST00000359154RBM10chrX

47006897

+WWP2chr16

69967872

+
intron-3CDSENST00000478410ENST00000448661RBM10chrX

47006897

+WWP2chr16

69967872

+
intron-3UTRENST00000478410ENST00000542271RBM10chrX

47006897

+WWP2chr16

69967872

+
intron-3UTRENST00000478410ENST00000544162RBM10chrX

47006897

+WWP2chr16

69967872

+
intron-3UTRENST00000478410ENST00000568684RBM10chrX

47006897

+WWP2chr16

69967872

+
intron-intronENST00000478410ENST00000356003RBM10chrX

47006897

+WWP2chr16

69967872

+
intron-intronENST00000478410ENST00000569174RBM10chrX

47006897

+WWP2chr16

69967872

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377604RBM10chrX47006897+ENST00000359154WWP2chr1669967872+34917594241689421
ENST00000377604RBM10chrX47006897+ENST00000448661WWP2chr1669967872+34907594241689421
ENST00000329236RBM10chrX47006897+ENST00000359154WWP2chr1669967872+3128396611326421
ENST00000329236RBM10chrX47006897+ENST00000448661WWP2chr1669967872+3127396611326421
ENST00000345781RBM10chrX47006897+ENST00000359154WWP2chr1669967872+3081349141279421
ENST00000345781RBM10chrX47006897+ENST00000448661WWP2chr1669967872+3080349141279421

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377604ENST00000359154RBM10chrX47006897+WWP2chr1669967872+0.0084528630.99154717
ENST00000377604ENST00000448661RBM10chrX47006897+WWP2chr1669967872+0.0085291920.99147075
ENST00000329236ENST00000359154RBM10chrX47006897+WWP2chr1669967872+0.0089247860.99107516
ENST00000329236ENST00000448661RBM10chrX47006897+WWP2chr1669967872+0.0089904370.9910096
ENST00000345781ENST00000359154RBM10chrX47006897+WWP2chr1669967872+0.0087388630.9912612
ENST00000345781ENST00000448661RBM10chrX47006897+WWP2chr1669967872+0.0088165780.9911834

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Fusion Genomic Features for RBM10-WWP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RBM10chrX47006897+WWP2chr1669967872+7.44E-070.9999993
RBM10chrX47006897+WWP2chr1669967872+7.44E-070.9999993

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RBM10-WWP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:47006897/chr16:69967872)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWWP2chrX:47006897chr16:69967872ENST000005422711221444_477444755.0DomainWW 4
TgeneWWP2chrX:47006897chr16:69967872ENST000005422711221536_870444755.0DomainHECT
TgeneWWP2chrX:47006897chr16:69967872ENST00000568684514300_333121432.0DomainWW 1
TgeneWWP2chrX:47006897chr16:69967872ENST00000568684514330_363121432.0DomainWW 2
TgeneWWP2chrX:47006897chr16:69967872ENST00000568684514405_437121432.0DomainWW 3
TgeneWWP2chrX:47006897chr16:69967872ENST00000568684514444_477121432.0DomainWW 4
TgeneWWP2chrX:47006897chr16:69967872ENST00000568684514536_870121432.0DomainHECT
TgeneWWP2chrX:47006897chr16:69967872ENST00000569174091_1170336.0DomainC2
TgeneWWP2chrX:47006897chr16:69967872ENST0000056917409300_3330336.0DomainWW 1
TgeneWWP2chrX:47006897chr16:69967872ENST0000056917409330_3630336.0DomainWW 2
TgeneWWP2chrX:47006897chr16:69967872ENST0000056917409405_4370336.0DomainWW 3
TgeneWWP2chrX:47006897chr16:69967872ENST0000056917409444_4770336.0DomainWW 4
TgeneWWP2chrX:47006897chr16:69967872ENST0000056917409536_8700336.0DomainHECT

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRBM10chrX:47006897chr16:69967872ENST00000329236+223113_1255853.0Compositional biasNote=Poly-Glu
HgeneRBM10chrX:47006897chr16:69967872ENST00000329236+223561_6075853.0Compositional biasNote=Tyr-rich
HgeneRBM10chrX:47006897chr16:69967872ENST00000329236+22380_875853.0Compositional biasNote=Poly-Arg
HgeneRBM10chrX:47006897chr16:69967872ENST00000345781+223113_1255854.0Compositional biasNote=Poly-Glu
HgeneRBM10chrX:47006897chr16:69967872ENST00000345781+223561_6075854.0Compositional biasNote=Tyr-rich
HgeneRBM10chrX:47006897chr16:69967872ENST00000345781+22380_875854.0Compositional biasNote=Poly-Arg
HgeneRBM10chrX:47006897chr16:69967872ENST00000377604+224113_1255931.0Compositional biasNote=Poly-Glu
HgeneRBM10chrX:47006897chr16:69967872ENST00000377604+224561_6075931.0Compositional biasNote=Tyr-rich
HgeneRBM10chrX:47006897chr16:69967872ENST00000377604+22480_875931.0Compositional biasNote=Poly-Arg
HgeneRBM10chrX:47006897chr16:69967872ENST00000329236+223129_2095853.0DomainRRM 1
HgeneRBM10chrX:47006897chr16:69967872ENST00000329236+223300_3845853.0DomainRRM 2
HgeneRBM10chrX:47006897chr16:69967872ENST00000329236+223858_9045853.0DomainG-patch
HgeneRBM10chrX:47006897chr16:69967872ENST00000345781+223129_2095854.0DomainRRM 1
HgeneRBM10chrX:47006897chr16:69967872ENST00000345781+223300_3845854.0DomainRRM 2
HgeneRBM10chrX:47006897chr16:69967872ENST00000345781+223858_9045854.0DomainG-patch
HgeneRBM10chrX:47006897chr16:69967872ENST00000377604+224129_2095931.0DomainRRM 1
HgeneRBM10chrX:47006897chr16:69967872ENST00000377604+224300_3845931.0DomainRRM 2
HgeneRBM10chrX:47006897chr16:69967872ENST00000377604+224858_9045931.0DomainG-patch
HgeneRBM10chrX:47006897chr16:69967872ENST00000329236+223212_2425853.0Zinc fingerRanBP2-type
HgeneRBM10chrX:47006897chr16:69967872ENST00000329236+223759_7845853.0Zinc fingerC2H2-type%3B atypical
HgeneRBM10chrX:47006897chr16:69967872ENST00000345781+223212_2425854.0Zinc fingerRanBP2-type
HgeneRBM10chrX:47006897chr16:69967872ENST00000345781+223759_7845854.0Zinc fingerC2H2-type%3B atypical
HgeneRBM10chrX:47006897chr16:69967872ENST00000377604+224212_2425931.0Zinc fingerRanBP2-type
HgeneRBM10chrX:47006897chr16:69967872ENST00000377604+224759_7845931.0Zinc fingerC2H2-type%3B atypical
TgeneWWP2chrX:47006897chr16:69967872ENST0000035600314231_117560871.0DomainC2
TgeneWWP2chrX:47006897chr16:69967872ENST000003560031423300_333560871.0DomainWW 1
TgeneWWP2chrX:47006897chr16:69967872ENST000003560031423330_363560871.0DomainWW 2
TgeneWWP2chrX:47006897chr16:69967872ENST000003560031423405_437560871.0DomainWW 3
TgeneWWP2chrX:47006897chr16:69967872ENST000003560031423444_477560871.0DomainWW 4
TgeneWWP2chrX:47006897chr16:69967872ENST000003560031423536_870560871.0DomainHECT
TgeneWWP2chrX:47006897chr16:69967872ENST0000035915415241_117560871.0DomainC2
TgeneWWP2chrX:47006897chr16:69967872ENST000003591541524300_333560871.0DomainWW 1
TgeneWWP2chrX:47006897chr16:69967872ENST000003591541524330_363560871.0DomainWW 2
TgeneWWP2chrX:47006897chr16:69967872ENST000003591541524405_437560871.0DomainWW 3
TgeneWWP2chrX:47006897chr16:69967872ENST000003591541524444_477560871.0DomainWW 4
TgeneWWP2chrX:47006897chr16:69967872ENST000003591541524536_870560871.0DomainHECT
TgeneWWP2chrX:47006897chr16:69967872ENST0000044866115241_117560871.0DomainC2
TgeneWWP2chrX:47006897chr16:69967872ENST000004486611524300_333560871.0DomainWW 1
TgeneWWP2chrX:47006897chr16:69967872ENST000004486611524330_363560871.0DomainWW 2
TgeneWWP2chrX:47006897chr16:69967872ENST000004486611524405_437560871.0DomainWW 3
TgeneWWP2chrX:47006897chr16:69967872ENST000004486611524444_477560871.0DomainWW 4
TgeneWWP2chrX:47006897chr16:69967872ENST000004486611524536_870560871.0DomainHECT
TgeneWWP2chrX:47006897chr16:69967872ENST0000054227112211_117444755.0DomainC2
TgeneWWP2chrX:47006897chr16:69967872ENST000005422711221300_333444755.0DomainWW 1
TgeneWWP2chrX:47006897chr16:69967872ENST000005422711221330_363444755.0DomainWW 2
TgeneWWP2chrX:47006897chr16:69967872ENST000005422711221405_437444755.0DomainWW 3
TgeneWWP2chrX:47006897chr16:69967872ENST000005686845141_117121432.0DomainC2


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Fusion Gene Sequence for RBM10-WWP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72754_72754_1_RBM10-WWP2_RBM10_chrX_47006897_ENST00000329236_WWP2_chr16_69967872_ENST00000359154_length(transcript)=3128nt_BP=396nt
GGTGGTCGGAGCGCCGACTCCCTTCTCGTCGTCGCCATTTTGAGCTGGTGACTGTGGCCGGCTGGGAGTAGGCGGCAGTGAGTTTCCCTG
GGAGGGCAGCGCGCTTGGCGCTTCTCCCCTCCCCCCGATCTGCCTCCAGTCTCGGACTTGGTTGTTGCGCGCTCCGGCTCCGGCTGAGCT
GGGAGAGTTGGAGGAGGTGGCGGCGGGCAGAGGTGATGTCTGGGAGCCCTTCCTTGACAGCCCGGGCCGAGAAGAGTCCCTGCAGGAAGC
ATCACCCAGGCTGGCAGATCATGGTAGCAGCAGCGGGGGTGGCTGGGAAGTGAAACGGAGCCAGCGGCTGAGGAGGGGCCCCAGCAGCCC
CCGAAGGCCCTATCAGGACATGGAGTATGAAAGACGAGAGTGGTTTTTCCTCCTGTCTCATGAGGTGCTCAACCCTATGTATTGTTTATT
TGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCTCCTCCATCAACCCGGACCACCTCACCTACTTTCGCTTTATAGG
CAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGGGCTTCACCCTCCCTTTCTACAAGCGGATGCTCAATAAGAGACC
AACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCATTGTCTGGATCAAAGAGAACAACCTGGAAGAATGTGGCCTGGA
GCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCCACGAGCTGAAGGAGGGCGGCGAGAGCATCCGGGTCACAGAGGA
GAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCCGAGGCGTGGAAGAGCAGACCAAAGCCTTCCTGGATGGCTTCAA
CGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGCTGGAGCTGATGCTGTGCGGCATGCAGGAGATAGACATGAGCGA
CTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGCAGATCCAGTGGTTCTGGCAGGTGGTGAAGGAGATGGACAACGA
GAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGCCCGTCGGGGGATTTGCCGAACTCATCGGTAGCAACGGACCACA
GAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAAGCCACACCTGCTTCAACCGTCTGGATCTTCCACCCTACAAGAG
CTACGAACAGCTGAGAGAGAAGCTGCTGTATGCCATTGAGGAGACCGAGGGCTTTGGACAGGAGTAACCGAGGCCGCCCCTCCCACGCCC
CCCAGCGCACATGTAGTCCTGAGTCCTCCCTGCCTGAGAGGCCACTGGCCCCGCAGCCCTTGGGAGGCCCCCGTGGATGTGGCCCTGTGT
GGGACCACACTGTCATCTCGCTGCTGGCAGAAAAGCCTGATCCCAGGAGGCCCTGCAGTTCCCCCGACCCGCGGATGGCAGTCTGGAATA
AAGCCCCCTAGTTGCCTTTGGCCCCACCTTTGCAAAGTTCCAGAGGGCTGACCCTCTCTGCAAAACTCTCCCCTGTCCTCTAGACCCCAC
CCTGGGTGTATGTGAGTGTGCAAGGGAAGGTGTTGCATCCCCAGGGGCTGCCGCAGAGGCCGGAGACCTCCTGGACTAGTTCGGCGAGGA
GACTGGCCACTGGGGGTGGCTGTTCGGGACTGAGAGCGCCAAGGGTCTTTGCCAGCAAAGGAGGTTCTGCCTGTAATTGAGCCTCTCTGA
TGATGGAGATGAAGTGAAGGTCTGAGGGAGCGGGCCCTGGGGCGAGGCCATCTCTGCCTGCCTCCCTAGCAGGCGCCAGCGGTGGAGGCT
GAGTCGCAGGACACATGCCGGCCAGTTAATTCATTCTCAGCCAATGAAGGTTTGTCTAAGCTGCCTGGGTATCCACGGGACAAAAACAGC
AAACTCCCTCAGACTTTGTCCATGTATAAACTTGAAGTGGTTGTGTTGTAGGGTTGCAGGTTTTTTGTTACGCTGCTGTCACTTTCTGTC
CAGGAGCTGGCACCCCAGGTGTTCTGAGACCTTGAGGGACCCAGACCTTTGGGTCCAAGAGTTTCCCAAACAGCCACGCCTCTCAGGAAC
CCACCTGGCGGTTCCGTGAGCTCAGGCAGGCCTGACCCGGCGGCACAGCCTGGCAGGGACCTCGTCCCCAAGCCTGGCAGAATGAGAGGG
GTTGAGGTCCCGAGCGCCACTCCTAGCCTTGCCGCCTTCAATAGAGAAGAAATCCCTTTGCTAGATAGGGTCCCCCAGGCAGTCCCCAGT
GGCGGGACACAGGGGTCCGGCTGTGGAGCTCCCCTGCCAGCCCCTGGAGCTCCAGGAGGGCCTGTTGGTCCCCTGTTCAGAATGGAGTGC
AGCCCGCCAGCGGAAAGTGTTCATTCTGCATAGGTGTGAGGCTTTATCTGCACACAGGACATGAAAACCAGCAGAAAGGCCCTGAGCTGC
TGCATAGCCCCATCTGATTTCTGCAGTTCCCGCCAGCCTCCAACACGGGGACTCTGCCGTAACTGGAATCTTCATAGGTCATATTGAAAT
CTTCAAGGTGACCATGCCCCACCGGGGTGCTGGGGCAGTAGTCATGGCAGACTCCCGGCCTGGGCCCCCAGGATTCTAGGACCCCCAGGC
AGCCCCTTGGACTGGTCCCGGGTGCCTTCCAAGCACAGTCTCCATGCTCCCAGATTCTCGACCTTCCCCCGGCCCGGGAGGTGCAGCCTG
CGTCTGCCTCTGTCGTGTGTGCTGATTTGAGTGGCTTAGCTTGCCACAGCGCAGCCTCTTCTGTCCCTTTCAGTCATTTGCTGTACTTCC
CTGTGGCACGTTACCATGGAAGCCGCTCCAGGGTGGGTCAGGGTGCAAGCTGCTGGTGAGGTTTGGAAGCATCAGGCTCACGGGTGTTCA
TGTGTGTTCGTGCGTGTGTGTGCGTACGTGTATATAACTGAAGTGTCTGTACGGAATGCCCTTTGCTAGCCATGGGCTGGTCACCAGATT

>72754_72754_1_RBM10-WWP2_RBM10_chrX_47006897_ENST00000329236_WWP2_chr16_69967872_ENST00000359154_length(amino acids)=421AA_BP=111
MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS
QRLRRGPSSPRRPYQDMEYERREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLP
FYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEE
QTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGF

--------------------------------------------------------------
>72754_72754_2_RBM10-WWP2_RBM10_chrX_47006897_ENST00000329236_WWP2_chr16_69967872_ENST00000448661_length(transcript)=3127nt_BP=396nt
GGTGGTCGGAGCGCCGACTCCCTTCTCGTCGTCGCCATTTTGAGCTGGTGACTGTGGCCGGCTGGGAGTAGGCGGCAGTGAGTTTCCCTG
GGAGGGCAGCGCGCTTGGCGCTTCTCCCCTCCCCCCGATCTGCCTCCAGTCTCGGACTTGGTTGTTGCGCGCTCCGGCTCCGGCTGAGCT
GGGAGAGTTGGAGGAGGTGGCGGCGGGCAGAGGTGATGTCTGGGAGCCCTTCCTTGACAGCCCGGGCCGAGAAGAGTCCCTGCAGGAAGC
ATCACCCAGGCTGGCAGATCATGGTAGCAGCAGCGGGGGTGGCTGGGAAGTGAAACGGAGCCAGCGGCTGAGGAGGGGCCCCAGCAGCCC
CCGAAGGCCCTATCAGGACATGGAGTATGAAAGACGAGAGTGGTTTTTCCTCCTGTCTCATGAGGTGCTCAACCCTATGTATTGTTTATT
TGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCTCCTCCATCAACCCGGACCACCTCACCTACTTTCGCTTTATAGG
CAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGGGCTTCACCCTCCCTTTCTACAAGCGGATGCTCAATAAGAGACC
AACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCATTGTCTGGATCAAAGAGAACAACCTGGAAGAATGTGGCCTGGA
GCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCCACGAGCTGAAGGAGGGCGGCGAGAGCATCCGGGTCACAGAGGA
GAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCCGAGGCGTGGAAGAGCAGACCAAAGCCTTCCTGGATGGCTTCAA
CGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGCTGGAGCTGATGCTGTGCGGCATGCAGGAGATAGACATGAGCGA
CTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGCAGATCCAGTGGTTCTGGCAGGTGGTGAAGGAGATGGACAACGA
GAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGCCCGTCGGGGGATTTGCCGAACTCATCGGTAGCAACGGACCACA
GAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAAGCCACACCTGCTTCAACCGTCTGGATCTTCCACCCTACAAGAG
CTACGAACAGCTGAGAGAGAAGCTGCTGTATGCCATTGAGGAGACCGAGGGCTTTGGACAGGAGTAACCGAGGCCGCCCCTCCCACGCCC
CCCAGCGCACATGTAGTCCTGAGTCCTCCCTGCCTGAGAGGCCACTGGCCCCGCAGCCCTTGGGAGGCCCCCGTGGATGTGGCCCTGTGT
GGGACCACACTGTCATCTCGCTGCTGGCAGAAAAGCCTGATCCCAGGAGGCCCTGCAGTTCCCCCGACCCGCGGATGGCAGTCTGGAATA
AAGCCCCCTAGTTGCCTTTGGCCCCACCTTTGCAAAGTTCCAGAGGGCTGACCCTCTCTGCAAAACTCTCCCCTGTCCTCTAGACCCCAC
CCTGGGTGTATGTGAGTGTGCAAGGGAAGGTGTTGCATCCCCAGGGGCTGCCGCAGAGGCCGGAGACCTCCTGGACTAGTTCGGCGAGGA
GACTGGCCACTGGGGGTGGCTGTTCGGGACTGAGAGCGCCAAGGGTCTTTGCCAGCAAAGGAGGTTCTGCCTGTAATTGAGCCTCTCTGA
TGATGGAGATGAAGTGAAGGTCTGAGGGAGCGGGCCCTGGGGCGAGGCCATCTCTGCCTGCCTCCCTAGCAGGCGCCAGCGGTGGAGGCT
GAGTCGCAGGACACATGCCGGCCAGTTAATTCATTCTCAGCCAATGAAGGTTTGTCTAAGCTGCCTGGGTATCCACGGGACAAAAACAGC
AAACTCCCTCAGACTTTGTCCATGTATAAACTTGAAGTGGTTGTGTTGTAGGGTTGCAGGTTTTTTGTTACGCTGCTGTCACTTTCTGTC
CAGGAGCTGGCACCCCAGGTGTTCTGAGACCTTGAGGGACCCAGACCTTTGGGTCCAAGAGTTTCCCAAACAGCCACGCCTCTCAGGAAC
CCACCTGGCGGTTCCGTGAGCTCAGGCAGGCCTGACCCGGCGGCACAGCCTGGCAGGGACCTCGTCCCCAAGCCTGGCAGAATGAGAGGG
GTTGAGGTCCCGAGCGCCACTCCTAGCCTTGCCGCCTTCAATAGAGAAGAAATCCCTTTGCTAGATAGGGTCCCCCAGGCAGTCCCCAGT
GGCGGGACACAGGGGTCCGGCTGTGGAGCTCCCCTGCCAGCCCCTGGAGCTCCAGGAGGGCCTGTTGGTCCCCTGTTCAGAATGGAGTGC
AGCCCGCCAGCGGAAAGTGTTCATTCTGCATAGGTGTGAGGCTTTATCTGCACACAGGACATGAAAACCAGCAGAAAGGCCCTGAGCTGC
TGCATAGCCCCATCTGATTTCTGCAGTTCCCGCCAGCCTCCAACACGGGGACTCTGCCGTAACTGGAATCTTCATAGGTCATATTGAAAT
CTTCAAGGTGACCATGCCCCACCGGGGTGCTGGGGCAGTAGTCATGGCAGACTCCCGGCCTGGGCCCCCAGGATTCTAGGACCCCCAGGC
AGCCCCTTGGACTGGTCCCGGGTGCCTTCCAAGCACAGTCTCCATGCTCCCAGATTCTCGACCTTCCCCCGGCCCGGGAGGTGCAGCCTG
CGTCTGCCTCTGTCGTGTGTGCTGATTTGAGTGGCTTAGCTTGCCACAGCGCAGCCTCTTCTGTCCCTTTCAGTCATTTGCTGTACTTCC
CTGTGGCACGTTACCATGGAAGCCGCTCCAGGGTGGGTCAGGGTGCAAGCTGCTGGTGAGGTTTGGAAGCATCAGGCTCACGGGTGTTCA
TGTGTGTTCGTGCGTGTGTGTGCGTACGTGTATATAACTGAAGTGTCTGTACGGAATGCCCTTTGCTAGCCATGGGCTGGTCACCAGATT

>72754_72754_2_RBM10-WWP2_RBM10_chrX_47006897_ENST00000329236_WWP2_chr16_69967872_ENST00000448661_length(amino acids)=421AA_BP=111
MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS
QRLRRGPSSPRRPYQDMEYERREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLP
FYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEE
QTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGF

--------------------------------------------------------------
>72754_72754_3_RBM10-WWP2_RBM10_chrX_47006897_ENST00000345781_WWP2_chr16_69967872_ENST00000359154_length(transcript)=3081nt_BP=349nt
GTGACTGTGGCCGGCTGGGAGTAGGCGGCAGTGAGTTTCCCTGGGAGGGCAGCGCGCTTGGCGCTTCTCCCCTCCCCCCGATCTGCCTCC
AGTCTCGGACTTGGTTGTTGCGCGCTCCGGCTCCGGCTGAGCTGGGAGAGTTGGAGGAGGTGGCGGCGGGCAGAGGTGATGTCTGGGAGC
CCTTCCTTGACAGCCCGGGCCGAGAAGAGTCCCTGCAGGAAGCATCACCCAGGCTGGCAGATCATGGTAGCAGCAGCGGGGGTGGCTGGG
AAGTGAAACGGAGCCAGCGGCTGAGGAGGGGCCCCAGCAGCCCCCGAAGGCCCTATCAGGACATGGAGTATGAAAGACGAGAGTGGTTTT
TCCTCCTGTCTCATGAGGTGCTCAACCCTATGTATTGTTTATTTGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCT
CCTCCATCAACCCGGACCACCTCACCTACTTTCGCTTTATAGGCAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGG
GCTTCACCCTCCCTTTCTACAAGCGGATGCTCAATAAGAGACCAACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCA
TTGTCTGGATCAAAGAGAACAACCTGGAAGAATGTGGCCTGGAGCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCC
ACGAGCTGAAGGAGGGCGGCGAGAGCATCCGGGTCACAGAGGAGAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCC
GAGGCGTGGAAGAGCAGACCAAAGCCTTCCTGGATGGCTTCAACGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGC
TGGAGCTGATGCTGTGCGGCATGCAGGAGATAGACATGAGCGACTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGC
AGATCCAGTGGTTCTGGCAGGTGGTGAAGGAGATGGACAACGAGAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGC
CCGTCGGGGGATTTGCCGAACTCATCGGTAGCAACGGACCACAGAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAA
GCCACACCTGCTTCAACCGTCTGGATCTTCCACCCTACAAGAGCTACGAACAGCTGAGAGAGAAGCTGCTGTATGCCATTGAGGAGACCG
AGGGCTTTGGACAGGAGTAACCGAGGCCGCCCCTCCCACGCCCCCCAGCGCACATGTAGTCCTGAGTCCTCCCTGCCTGAGAGGCCACTG
GCCCCGCAGCCCTTGGGAGGCCCCCGTGGATGTGGCCCTGTGTGGGACCACACTGTCATCTCGCTGCTGGCAGAAAAGCCTGATCCCAGG
AGGCCCTGCAGTTCCCCCGACCCGCGGATGGCAGTCTGGAATAAAGCCCCCTAGTTGCCTTTGGCCCCACCTTTGCAAAGTTCCAGAGGG
CTGACCCTCTCTGCAAAACTCTCCCCTGTCCTCTAGACCCCACCCTGGGTGTATGTGAGTGTGCAAGGGAAGGTGTTGCATCCCCAGGGG
CTGCCGCAGAGGCCGGAGACCTCCTGGACTAGTTCGGCGAGGAGACTGGCCACTGGGGGTGGCTGTTCGGGACTGAGAGCGCCAAGGGTC
TTTGCCAGCAAAGGAGGTTCTGCCTGTAATTGAGCCTCTCTGATGATGGAGATGAAGTGAAGGTCTGAGGGAGCGGGCCCTGGGGCGAGG
CCATCTCTGCCTGCCTCCCTAGCAGGCGCCAGCGGTGGAGGCTGAGTCGCAGGACACATGCCGGCCAGTTAATTCATTCTCAGCCAATGA
AGGTTTGTCTAAGCTGCCTGGGTATCCACGGGACAAAAACAGCAAACTCCCTCAGACTTTGTCCATGTATAAACTTGAAGTGGTTGTGTT
GTAGGGTTGCAGGTTTTTTGTTACGCTGCTGTCACTTTCTGTCCAGGAGCTGGCACCCCAGGTGTTCTGAGACCTTGAGGGACCCAGACC
TTTGGGTCCAAGAGTTTCCCAAACAGCCACGCCTCTCAGGAACCCACCTGGCGGTTCCGTGAGCTCAGGCAGGCCTGACCCGGCGGCACA
GCCTGGCAGGGACCTCGTCCCCAAGCCTGGCAGAATGAGAGGGGTTGAGGTCCCGAGCGCCACTCCTAGCCTTGCCGCCTTCAATAGAGA
AGAAATCCCTTTGCTAGATAGGGTCCCCCAGGCAGTCCCCAGTGGCGGGACACAGGGGTCCGGCTGTGGAGCTCCCCTGCCAGCCCCTGG
AGCTCCAGGAGGGCCTGTTGGTCCCCTGTTCAGAATGGAGTGCAGCCCGCCAGCGGAAAGTGTTCATTCTGCATAGGTGTGAGGCTTTAT
CTGCACACAGGACATGAAAACCAGCAGAAAGGCCCTGAGCTGCTGCATAGCCCCATCTGATTTCTGCAGTTCCCGCCAGCCTCCAACACG
GGGACTCTGCCGTAACTGGAATCTTCATAGGTCATATTGAAATCTTCAAGGTGACCATGCCCCACCGGGGTGCTGGGGCAGTAGTCATGG
CAGACTCCCGGCCTGGGCCCCCAGGATTCTAGGACCCCCAGGCAGCCCCTTGGACTGGTCCCGGGTGCCTTCCAAGCACAGTCTCCATGC
TCCCAGATTCTCGACCTTCCCCCGGCCCGGGAGGTGCAGCCTGCGTCTGCCTCTGTCGTGTGTGCTGATTTGAGTGGCTTAGCTTGCCAC
AGCGCAGCCTCTTCTGTCCCTTTCAGTCATTTGCTGTACTTCCCTGTGGCACGTTACCATGGAAGCCGCTCCAGGGTGGGTCAGGGTGCA
AGCTGCTGGTGAGGTTTGGAAGCATCAGGCTCACGGGTGTTCATGTGTGTTCGTGCGTGTGTGTGCGTACGTGTATATAACTGAAGTGTC
TGTACGGAATGCCCTTTGCTAGCCATGGGCTGGTCACCAGATTGTTTTGTAATGCCCGCCCCTTGCCTCGATATTGCCAGTTTCTTGTGC

>72754_72754_3_RBM10-WWP2_RBM10_chrX_47006897_ENST00000345781_WWP2_chr16_69967872_ENST00000359154_length(amino acids)=421AA_BP=111
MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS
QRLRRGPSSPRRPYQDMEYERREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLP
FYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEE
QTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGF

--------------------------------------------------------------
>72754_72754_4_RBM10-WWP2_RBM10_chrX_47006897_ENST00000345781_WWP2_chr16_69967872_ENST00000448661_length(transcript)=3080nt_BP=349nt
GTGACTGTGGCCGGCTGGGAGTAGGCGGCAGTGAGTTTCCCTGGGAGGGCAGCGCGCTTGGCGCTTCTCCCCTCCCCCCGATCTGCCTCC
AGTCTCGGACTTGGTTGTTGCGCGCTCCGGCTCCGGCTGAGCTGGGAGAGTTGGAGGAGGTGGCGGCGGGCAGAGGTGATGTCTGGGAGC
CCTTCCTTGACAGCCCGGGCCGAGAAGAGTCCCTGCAGGAAGCATCACCCAGGCTGGCAGATCATGGTAGCAGCAGCGGGGGTGGCTGGG
AAGTGAAACGGAGCCAGCGGCTGAGGAGGGGCCCCAGCAGCCCCCGAAGGCCCTATCAGGACATGGAGTATGAAAGACGAGAGTGGTTTT
TCCTCCTGTCTCATGAGGTGCTCAACCCTATGTATTGTTTATTTGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCT
CCTCCATCAACCCGGACCACCTCACCTACTTTCGCTTTATAGGCAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGG
GCTTCACCCTCCCTTTCTACAAGCGGATGCTCAATAAGAGACCAACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCA
TTGTCTGGATCAAAGAGAACAACCTGGAAGAATGTGGCCTGGAGCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCC
ACGAGCTGAAGGAGGGCGGCGAGAGCATCCGGGTCACAGAGGAGAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCC
GAGGCGTGGAAGAGCAGACCAAAGCCTTCCTGGATGGCTTCAACGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGC
TGGAGCTGATGCTGTGCGGCATGCAGGAGATAGACATGAGCGACTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGC
AGATCCAGTGGTTCTGGCAGGTGGTGAAGGAGATGGACAACGAGAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGC
CCGTCGGGGGATTTGCCGAACTCATCGGTAGCAACGGACCACAGAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAA
GCCACACCTGCTTCAACCGTCTGGATCTTCCACCCTACAAGAGCTACGAACAGCTGAGAGAGAAGCTGCTGTATGCCATTGAGGAGACCG
AGGGCTTTGGACAGGAGTAACCGAGGCCGCCCCTCCCACGCCCCCCAGCGCACATGTAGTCCTGAGTCCTCCCTGCCTGAGAGGCCACTG
GCCCCGCAGCCCTTGGGAGGCCCCCGTGGATGTGGCCCTGTGTGGGACCACACTGTCATCTCGCTGCTGGCAGAAAAGCCTGATCCCAGG
AGGCCCTGCAGTTCCCCCGACCCGCGGATGGCAGTCTGGAATAAAGCCCCCTAGTTGCCTTTGGCCCCACCTTTGCAAAGTTCCAGAGGG
CTGACCCTCTCTGCAAAACTCTCCCCTGTCCTCTAGACCCCACCCTGGGTGTATGTGAGTGTGCAAGGGAAGGTGTTGCATCCCCAGGGG
CTGCCGCAGAGGCCGGAGACCTCCTGGACTAGTTCGGCGAGGAGACTGGCCACTGGGGGTGGCTGTTCGGGACTGAGAGCGCCAAGGGTC
TTTGCCAGCAAAGGAGGTTCTGCCTGTAATTGAGCCTCTCTGATGATGGAGATGAAGTGAAGGTCTGAGGGAGCGGGCCCTGGGGCGAGG
CCATCTCTGCCTGCCTCCCTAGCAGGCGCCAGCGGTGGAGGCTGAGTCGCAGGACACATGCCGGCCAGTTAATTCATTCTCAGCCAATGA
AGGTTTGTCTAAGCTGCCTGGGTATCCACGGGACAAAAACAGCAAACTCCCTCAGACTTTGTCCATGTATAAACTTGAAGTGGTTGTGTT
GTAGGGTTGCAGGTTTTTTGTTACGCTGCTGTCACTTTCTGTCCAGGAGCTGGCACCCCAGGTGTTCTGAGACCTTGAGGGACCCAGACC
TTTGGGTCCAAGAGTTTCCCAAACAGCCACGCCTCTCAGGAACCCACCTGGCGGTTCCGTGAGCTCAGGCAGGCCTGACCCGGCGGCACA
GCCTGGCAGGGACCTCGTCCCCAAGCCTGGCAGAATGAGAGGGGTTGAGGTCCCGAGCGCCACTCCTAGCCTTGCCGCCTTCAATAGAGA
AGAAATCCCTTTGCTAGATAGGGTCCCCCAGGCAGTCCCCAGTGGCGGGACACAGGGGTCCGGCTGTGGAGCTCCCCTGCCAGCCCCTGG
AGCTCCAGGAGGGCCTGTTGGTCCCCTGTTCAGAATGGAGTGCAGCCCGCCAGCGGAAAGTGTTCATTCTGCATAGGTGTGAGGCTTTAT
CTGCACACAGGACATGAAAACCAGCAGAAAGGCCCTGAGCTGCTGCATAGCCCCATCTGATTTCTGCAGTTCCCGCCAGCCTCCAACACG
GGGACTCTGCCGTAACTGGAATCTTCATAGGTCATATTGAAATCTTCAAGGTGACCATGCCCCACCGGGGTGCTGGGGCAGTAGTCATGG
CAGACTCCCGGCCTGGGCCCCCAGGATTCTAGGACCCCCAGGCAGCCCCTTGGACTGGTCCCGGGTGCCTTCCAAGCACAGTCTCCATGC
TCCCAGATTCTCGACCTTCCCCCGGCCCGGGAGGTGCAGCCTGCGTCTGCCTCTGTCGTGTGTGCTGATTTGAGTGGCTTAGCTTGCCAC
AGCGCAGCCTCTTCTGTCCCTTTCAGTCATTTGCTGTACTTCCCTGTGGCACGTTACCATGGAAGCCGCTCCAGGGTGGGTCAGGGTGCA
AGCTGCTGGTGAGGTTTGGAAGCATCAGGCTCACGGGTGTTCATGTGTGTTCGTGCGTGTGTGTGCGTACGTGTATATAACTGAAGTGTC
TGTACGGAATGCCCTTTGCTAGCCATGGGCTGGTCACCAGATTGTTTTGTAATGCCCGCCCCTTGCCTCGATATTGCCAGTTTCTTGTGC

>72754_72754_4_RBM10-WWP2_RBM10_chrX_47006897_ENST00000345781_WWP2_chr16_69967872_ENST00000448661_length(amino acids)=421AA_BP=111
MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS
QRLRRGPSSPRRPYQDMEYERREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLP
FYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEE
QTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGF

--------------------------------------------------------------
>72754_72754_5_RBM10-WWP2_RBM10_chrX_47006897_ENST00000377604_WWP2_chr16_69967872_ENST00000359154_length(transcript)=3491nt_BP=759nt
GCCAACCATTTTCGGCCAGGCTGAGAAATTTCTTATTGATGGGTCTGCTCATTTCCTGCATAGGAAGAAATCGGTGACATTTGGGTGGAT
ACAGTTCCCAGCCAATCGCCCCGAGTTCCCTCGCCCACTGGGGAAAGAGGCAGAGCTTCCGCTAGTCTTTCATCTTCAAAGGAAATCAAG
CTTCTAAAAAGCGGGCCCTGCCGAATTGGCTAATAGCTACTCCTTTTCTCCACTAGGGGAGCGTTCGCAAGGGGTGTGGGGAGGTGGCCA
GCGCTTGCCAATCAGAGGAGGCCAGGGCTGTCCCCTAGCGGGCGGTGACCAATCGCCGGGGCCGGCCAGAGCGCGCTTCCTTAGTAGGTG
GATGGTGGTCGGAGCGCCGACTCCCTTCTCGTCGTCGCCATTTTGAGCTGGTGACTGTGGCCGGCTGGGAGTAGGCGGCAGTGAGTTTCC
CTGGGAGGGCAGCGCGCTTGGCGCTTCTCCCCTCCCCCCGATCTGCCTCCAGTCTCGGACTTGGTTGTTGCGCGCTCCGGCTCCGGCTGA
GCTGGGAGAGTTGGAGGAGGTGGCGGCGGGCAGAGGTGATGTCTGGGAGCCCTTCCTTGACAGCCCGGGCCGAGAAGAGTCCCTGCAGGA
AGCATCACCCAGGCTGGCAGATCATGGTAGCAGCAGCGGGGGTGGCTGGGAAGTGAAACGGAGCCAGCGGCTGAGGAGGGGCCCCAGCAG
CCCCCGAAGGCCCTATCAGGACATGGAGTATGAAAGACGAGAGTGGTTTTTCCTCCTGTCTCATGAGGTGCTCAACCCTATGTATTGTTT
ATTTGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCTCCTCCATCAACCCGGACCACCTCACCTACTTTCGCTTTAT
AGGCAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGGGCTTCACCCTCCCTTTCTACAAGCGGATGCTCAATAAGAG
ACCAACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCATTGTCTGGATCAAAGAGAACAACCTGGAAGAATGTGGCCT
GGAGCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCCACGAGCTGAAGGAGGGCGGCGAGAGCATCCGGGTCACAGA
GGAGAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCCGAGGCGTGGAAGAGCAGACCAAAGCCTTCCTGGATGGCTT
CAACGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGCTGGAGCTGATGCTGTGCGGCATGCAGGAGATAGACATGAG
CGACTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGCAGATCCAGTGGTTCTGGCAGGTGGTGAAGGAGATGGACAA
CGAGAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGCCCGTCGGGGGATTTGCCGAACTCATCGGTAGCAACGGACC
ACAGAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAAGCCACACCTGCTTCAACCGTCTGGATCTTCCACCCTACAA
GAGCTACGAACAGCTGAGAGAGAAGCTGCTGTATGCCATTGAGGAGACCGAGGGCTTTGGACAGGAGTAACCGAGGCCGCCCCTCCCACG
CCCCCCAGCGCACATGTAGTCCTGAGTCCTCCCTGCCTGAGAGGCCACTGGCCCCGCAGCCCTTGGGAGGCCCCCGTGGATGTGGCCCTG
TGTGGGACCACACTGTCATCTCGCTGCTGGCAGAAAAGCCTGATCCCAGGAGGCCCTGCAGTTCCCCCGACCCGCGGATGGCAGTCTGGA
ATAAAGCCCCCTAGTTGCCTTTGGCCCCACCTTTGCAAAGTTCCAGAGGGCTGACCCTCTCTGCAAAACTCTCCCCTGTCCTCTAGACCC
CACCCTGGGTGTATGTGAGTGTGCAAGGGAAGGTGTTGCATCCCCAGGGGCTGCCGCAGAGGCCGGAGACCTCCTGGACTAGTTCGGCGA
GGAGACTGGCCACTGGGGGTGGCTGTTCGGGACTGAGAGCGCCAAGGGTCTTTGCCAGCAAAGGAGGTTCTGCCTGTAATTGAGCCTCTC
TGATGATGGAGATGAAGTGAAGGTCTGAGGGAGCGGGCCCTGGGGCGAGGCCATCTCTGCCTGCCTCCCTAGCAGGCGCCAGCGGTGGAG
GCTGAGTCGCAGGACACATGCCGGCCAGTTAATTCATTCTCAGCCAATGAAGGTTTGTCTAAGCTGCCTGGGTATCCACGGGACAAAAAC
AGCAAACTCCCTCAGACTTTGTCCATGTATAAACTTGAAGTGGTTGTGTTGTAGGGTTGCAGGTTTTTTGTTACGCTGCTGTCACTTTCT
GTCCAGGAGCTGGCACCCCAGGTGTTCTGAGACCTTGAGGGACCCAGACCTTTGGGTCCAAGAGTTTCCCAAACAGCCACGCCTCTCAGG
AACCCACCTGGCGGTTCCGTGAGCTCAGGCAGGCCTGACCCGGCGGCACAGCCTGGCAGGGACCTCGTCCCCAAGCCTGGCAGAATGAGA
GGGGTTGAGGTCCCGAGCGCCACTCCTAGCCTTGCCGCCTTCAATAGAGAAGAAATCCCTTTGCTAGATAGGGTCCCCCAGGCAGTCCCC
AGTGGCGGGACACAGGGGTCCGGCTGTGGAGCTCCCCTGCCAGCCCCTGGAGCTCCAGGAGGGCCTGTTGGTCCCCTGTTCAGAATGGAG
TGCAGCCCGCCAGCGGAAAGTGTTCATTCTGCATAGGTGTGAGGCTTTATCTGCACACAGGACATGAAAACCAGCAGAAAGGCCCTGAGC
TGCTGCATAGCCCCATCTGATTTCTGCAGTTCCCGCCAGCCTCCAACACGGGGACTCTGCCGTAACTGGAATCTTCATAGGTCATATTGA
AATCTTCAAGGTGACCATGCCCCACCGGGGTGCTGGGGCAGTAGTCATGGCAGACTCCCGGCCTGGGCCCCCAGGATTCTAGGACCCCCA
GGCAGCCCCTTGGACTGGTCCCGGGTGCCTTCCAAGCACAGTCTCCATGCTCCCAGATTCTCGACCTTCCCCCGGCCCGGGAGGTGCAGC
CTGCGTCTGCCTCTGTCGTGTGTGCTGATTTGAGTGGCTTAGCTTGCCACAGCGCAGCCTCTTCTGTCCCTTTCAGTCATTTGCTGTACT
TCCCTGTGGCACGTTACCATGGAAGCCGCTCCAGGGTGGGTCAGGGTGCAAGCTGCTGGTGAGGTTTGGAAGCATCAGGCTCACGGGTGT
TCATGTGTGTTCGTGCGTGTGTGTGCGTACGTGTATATAACTGAAGTGTCTGTACGGAATGCCCTTTGCTAGCCATGGGCTGGTCACCAG

>72754_72754_5_RBM10-WWP2_RBM10_chrX_47006897_ENST00000377604_WWP2_chr16_69967872_ENST00000359154_length(amino acids)=421AA_BP=111
MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS
QRLRRGPSSPRRPYQDMEYERREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLP
FYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEE
QTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGF

--------------------------------------------------------------
>72754_72754_6_RBM10-WWP2_RBM10_chrX_47006897_ENST00000377604_WWP2_chr16_69967872_ENST00000448661_length(transcript)=3490nt_BP=759nt
GCCAACCATTTTCGGCCAGGCTGAGAAATTTCTTATTGATGGGTCTGCTCATTTCCTGCATAGGAAGAAATCGGTGACATTTGGGTGGAT
ACAGTTCCCAGCCAATCGCCCCGAGTTCCCTCGCCCACTGGGGAAAGAGGCAGAGCTTCCGCTAGTCTTTCATCTTCAAAGGAAATCAAG
CTTCTAAAAAGCGGGCCCTGCCGAATTGGCTAATAGCTACTCCTTTTCTCCACTAGGGGAGCGTTCGCAAGGGGTGTGGGGAGGTGGCCA
GCGCTTGCCAATCAGAGGAGGCCAGGGCTGTCCCCTAGCGGGCGGTGACCAATCGCCGGGGCCGGCCAGAGCGCGCTTCCTTAGTAGGTG
GATGGTGGTCGGAGCGCCGACTCCCTTCTCGTCGTCGCCATTTTGAGCTGGTGACTGTGGCCGGCTGGGAGTAGGCGGCAGTGAGTTTCC
CTGGGAGGGCAGCGCGCTTGGCGCTTCTCCCCTCCCCCCGATCTGCCTCCAGTCTCGGACTTGGTTGTTGCGCGCTCCGGCTCCGGCTGA
GCTGGGAGAGTTGGAGGAGGTGGCGGCGGGCAGAGGTGATGTCTGGGAGCCCTTCCTTGACAGCCCGGGCCGAGAAGAGTCCCTGCAGGA
AGCATCACCCAGGCTGGCAGATCATGGTAGCAGCAGCGGGGGTGGCTGGGAAGTGAAACGGAGCCAGCGGCTGAGGAGGGGCCCCAGCAG
CCCCCGAAGGCCCTATCAGGACATGGAGTATGAAAGACGAGAGTGGTTTTTCCTCCTGTCTCATGAGGTGCTCAACCCTATGTATTGTTT
ATTTGAATATGCCGGAAAGAACAATTACTGCCTGCAGATCAACCCCGCCTCCTCCATCAACCCGGACCACCTCACCTACTTTCGCTTTAT
AGGCAGATTCATCGCCATGGCGCTGTACCATGGAAAGTTCATCGACACGGGCTTCACCCTCCCTTTCTACAAGCGGATGCTCAATAAGAG
ACCAACCCTGAAAGACCTGGAGTCCATTGACCCTGAGTTCTACAACTCCATTGTCTGGATCAAAGAGAACAACCTGGAAGAATGTGGCCT
GGAGCTGTACTTCATCCAGGACATGGAGATACTGGGCAAGGTGACGACCCACGAGCTGAAGGAGGGCGGCGAGAGCATCCGGGTCACAGA
GGAGAACAAGGAAGAGTACATCATGCTGCTGACTGACTGGCGTTTCACCCGAGGCGTGGAAGAGCAGACCAAAGCCTTCCTGGATGGCTT
CAACGAGGTGGCCCCGCTGGAGTGGCTGCGCTACTTTGACGAGAAAGAGCTGGAGCTGATGCTGTGCGGCATGCAGGAGATAGACATGAG
CGACTGGCAGAAGAGCACCATCTACCGGCACTACACCAAGAACAGCAAGCAGATCCAGTGGTTCTGGCAGGTGGTGAAGGAGATGGACAA
CGAGAAGAGGATCCGGCTGCTGCAGTTTGTCACCGGTACCTGCCGCCTGCCCGTCGGGGGATTTGCCGAACTCATCGGTAGCAACGGACC
ACAGAAGTTTTGCATTGACAAAGTTGGCAAGGAAACCTGGCTGCCCAGAAGCCACACCTGCTTCAACCGTCTGGATCTTCCACCCTACAA
GAGCTACGAACAGCTGAGAGAGAAGCTGCTGTATGCCATTGAGGAGACCGAGGGCTTTGGACAGGAGTAACCGAGGCCGCCCCTCCCACG
CCCCCCAGCGCACATGTAGTCCTGAGTCCTCCCTGCCTGAGAGGCCACTGGCCCCGCAGCCCTTGGGAGGCCCCCGTGGATGTGGCCCTG
TGTGGGACCACACTGTCATCTCGCTGCTGGCAGAAAAGCCTGATCCCAGGAGGCCCTGCAGTTCCCCCGACCCGCGGATGGCAGTCTGGA
ATAAAGCCCCCTAGTTGCCTTTGGCCCCACCTTTGCAAAGTTCCAGAGGGCTGACCCTCTCTGCAAAACTCTCCCCTGTCCTCTAGACCC
CACCCTGGGTGTATGTGAGTGTGCAAGGGAAGGTGTTGCATCCCCAGGGGCTGCCGCAGAGGCCGGAGACCTCCTGGACTAGTTCGGCGA
GGAGACTGGCCACTGGGGGTGGCTGTTCGGGACTGAGAGCGCCAAGGGTCTTTGCCAGCAAAGGAGGTTCTGCCTGTAATTGAGCCTCTC
TGATGATGGAGATGAAGTGAAGGTCTGAGGGAGCGGGCCCTGGGGCGAGGCCATCTCTGCCTGCCTCCCTAGCAGGCGCCAGCGGTGGAG
GCTGAGTCGCAGGACACATGCCGGCCAGTTAATTCATTCTCAGCCAATGAAGGTTTGTCTAAGCTGCCTGGGTATCCACGGGACAAAAAC
AGCAAACTCCCTCAGACTTTGTCCATGTATAAACTTGAAGTGGTTGTGTTGTAGGGTTGCAGGTTTTTTGTTACGCTGCTGTCACTTTCT
GTCCAGGAGCTGGCACCCCAGGTGTTCTGAGACCTTGAGGGACCCAGACCTTTGGGTCCAAGAGTTTCCCAAACAGCCACGCCTCTCAGG
AACCCACCTGGCGGTTCCGTGAGCTCAGGCAGGCCTGACCCGGCGGCACAGCCTGGCAGGGACCTCGTCCCCAAGCCTGGCAGAATGAGA
GGGGTTGAGGTCCCGAGCGCCACTCCTAGCCTTGCCGCCTTCAATAGAGAAGAAATCCCTTTGCTAGATAGGGTCCCCCAGGCAGTCCCC
AGTGGCGGGACACAGGGGTCCGGCTGTGGAGCTCCCCTGCCAGCCCCTGGAGCTCCAGGAGGGCCTGTTGGTCCCCTGTTCAGAATGGAG
TGCAGCCCGCCAGCGGAAAGTGTTCATTCTGCATAGGTGTGAGGCTTTATCTGCACACAGGACATGAAAACCAGCAGAAAGGCCCTGAGC
TGCTGCATAGCCCCATCTGATTTCTGCAGTTCCCGCCAGCCTCCAACACGGGGACTCTGCCGTAACTGGAATCTTCATAGGTCATATTGA
AATCTTCAAGGTGACCATGCCCCACCGGGGTGCTGGGGCAGTAGTCATGGCAGACTCCCGGCCTGGGCCCCCAGGATTCTAGGACCCCCA
GGCAGCCCCTTGGACTGGTCCCGGGTGCCTTCCAAGCACAGTCTCCATGCTCCCAGATTCTCGACCTTCCCCCGGCCCGGGAGGTGCAGC
CTGCGTCTGCCTCTGTCGTGTGTGCTGATTTGAGTGGCTTAGCTTGCCACAGCGCAGCCTCTTCTGTCCCTTTCAGTCATTTGCTGTACT
TCCCTGTGGCACGTTACCATGGAAGCCGCTCCAGGGTGGGTCAGGGTGCAAGCTGCTGGTGAGGTTTGGAAGCATCAGGCTCACGGGTGT
TCATGTGTGTTCGTGCGTGTGTGTGCGTACGTGTATATAACTGAAGTGTCTGTACGGAATGCCCTTTGCTAGCCATGGGCTGGTCACCAG

>72754_72754_6_RBM10-WWP2_RBM10_chrX_47006897_ENST00000377604_WWP2_chr16_69967872_ENST00000448661_length(amino acids)=421AA_BP=111
MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS
QRLRRGPSSPRRPYQDMEYERREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLP
FYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEE
QTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGF

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Fusion Gene PPI Analysis for RBM10-WWP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RBM10-WWP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RBM10-WWP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource