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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RBM23-PSMB5 (FusionGDB2 ID:72814)

Fusion Gene Summary for RBM23-PSMB5

Fusion gene summary

Fusion gene information	Fusion gene name: RBM23-PSMB5
	Fusion gene ID: 72814
		Hgene	Tgene
	Gene symbol	RBM23	PSMB5
	Gene ID	55147	5693
	Gene name	RNA binding motif protein 23	proteasome 20S subunit beta 5
	Synonyms	CAPERbeta\|PP239\|RNPC4	LMPX\|MB1\|X
	Cytomap	14q11.2	14q11.2
	Type of gene	protein-coding	protein-coding
	Description	probable RNA-binding protein 23RNA-binding region (RNP1, RRM) containing 4RNA-binding region-containing protein 4coactivator of activating protein-1 and estrogen recep- tors betasplicing factor SF2	proteasome subunit beta type-5PSX large multifunctional protease Xmacropain epsilon chainmulticatalytic endopeptidase complex epsilon chainproteasome (prosome, macropain) subunit, beta type, 5proteasome beta 5 subunitproteasome catalytic subunit 3p
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000346528, ENST00000359890, ENST00000399922, ENST00000556984, ENST00000542016, ENST00000555209,	ENST00000425762, ENST00000460922, ENST00000361611, ENST00000493471,
Fusion gene scores	* DoF score	3 X 2 X 3=18	5 X 4 X 3=60
	# samples	3	5
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RBM23 [Title/Abstract] AND PSMB5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RBM23(23375404)-PSMB5(23502883), # samples:1
Anticipated loss of major functional domain due to fusion event.	RBM23-PSMB5 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. RBM23-PSMB5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. RBM23-PSMB5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PSMB5	GO:0006508	proteolysis	17540904

Fusion gene breakpoints across RBM23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PSMB5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-12-5295-01A	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-

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Fusion Gene ORF analysis for RBM23-PSMB5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000346528	ENST00000425762	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5CDS-5UTR	ENST00000359890	ENST00000425762	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5CDS-5UTR	ENST00000399922	ENST00000425762	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5CDS-5UTR	ENST00000556984	ENST00000425762	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5CDS-intron	ENST00000346528	ENST00000460922	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5CDS-intron	ENST00000359890	ENST00000460922	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5CDS-intron	ENST00000399922	ENST00000460922	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5CDS-intron	ENST00000556984	ENST00000460922	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5UTR-3CDS	ENST00000542016	ENST00000361611	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5UTR-3CDS	ENST00000542016	ENST00000493471	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5UTR-3CDS	ENST00000555209	ENST00000361611	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5UTR-3CDS	ENST00000555209	ENST00000493471	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5UTR-5UTR	ENST00000542016	ENST00000425762	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5UTR-5UTR	ENST00000555209	ENST00000425762	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5UTR-intron	ENST00000542016	ENST00000460922	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
5UTR-intron	ENST00000555209	ENST00000460922	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
Frame-shift	ENST00000556984	ENST00000361611	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
Frame-shift	ENST00000556984	ENST00000493471	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
In-frame	ENST00000346528	ENST00000361611	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
In-frame	ENST00000346528	ENST00000493471	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
In-frame	ENST00000359890	ENST00000361611	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
In-frame	ENST00000359890	ENST00000493471	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
In-frame	ENST00000399922	ENST00000361611	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-
In-frame	ENST00000399922	ENST00000493471	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000359890	RBM23	chr14	23375404	-	ENST00000361611	PSMB5	chr14	23502883	-	1429	597	696	1190	164
ENST00000359890	RBM23	chr14	23375404	-	ENST00000493471	PSMB5	chr14	23502883	-	1507	597	570	109	153
ENST00000399922	RBM23	chr14	23375404	-	ENST00000361611	PSMB5	chr14	23502883	-	1379	547	646	1140	164
ENST00000399922	RBM23	chr14	23375404	-	ENST00000493471	PSMB5	chr14	23502883	-	1457	547	520	107	137
ENST00000346528	RBM23	chr14	23375404	-	ENST00000361611	PSMB5	chr14	23502883	-	1375	543	642	1136	164
ENST00000346528	RBM23	chr14	23375404	-	ENST00000493471	PSMB5	chr14	23502883	-	1453	543	516	103	137

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000359890	ENST00000361611	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-	0.001956502	0.9980434
ENST00000359890	ENST00000493471	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-	0.010417843	0.9895822
ENST00000399922	ENST00000361611	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-	0.001179566	0.99882036
ENST00000399922	ENST00000493471	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-	0.011936412	0.9880635
ENST00000346528	ENST00000361611	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-	0.001302554	0.99869746
ENST00000346528	ENST00000493471	RBM23	chr14	23375404	-	PSMB5	chr14	23502883	-	0.0108029	0.9891971

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Fusion Genomic Features for RBM23-PSMB5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RBM23-PSMB5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:23375404/chr14:23502883)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RBM23

chr14:23375404

chr14:23502883

ENST00000359890

63_127

133

440.0

Compositional bias

Note=Arg-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RBM23

chr14:23375404

chr14:23502883

ENST00000346528

371_424

117

406.0

Compositional bias

Note=Ala-rich

Hgene

RBM23

chr14:23375404

chr14:23502883

ENST00000346528

63_127

117

406.0

Compositional bias

Note=Arg-rich

Hgene

RBM23

chr14:23375404

chr14:23502883

ENST00000359890

371_424

133

440.0

Compositional bias

Note=Ala-rich

Hgene

RBM23

chr14:23375404

chr14:23502883

ENST00000399922

371_424

117

424.0

Compositional bias

Note=Ala-rich

Hgene

RBM23

chr14:23375404

chr14:23502883

ENST00000399922

63_127

117

424.0

Compositional bias

Note=Arg-rich

Hgene

RBM23

chr14:23375404

chr14:23502883

ENST00000346528

166_243

117

406.0

Domain

RRM 1

Hgene

RBM23

chr14:23375404

chr14:23502883

ENST00000346528

263_341

117

406.0

Domain

RRM 2

Hgene

RBM23

chr14:23375404

chr14:23502883

ENST00000359890

166_243

133

440.0

Domain

RRM 1

Hgene

RBM23

chr14:23375404

chr14:23502883

ENST00000359890

263_341

133

440.0

Domain

RRM 2

Hgene

RBM23

chr14:23375404

chr14:23502883

ENST00000399922

166_243

117

424.0

Domain

RRM 1

Hgene

RBM23

chr14:23375404

chr14:23502883

ENST00000399922

263_341

117

424.0

Domain

RRM 2

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Fusion Gene Sequence for RBM23-PSMB5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>72814_72814_1_RBM23-PSMB5_RBM23_chr14_23375404_ENST00000346528_PSMB5_chr14_23502883_ENST00000361611_length(transcript)=1375nt_BP=543nt
GCAGATTGGGGAAGGTTCTGGAAGACGGCAGAGCTGCCGCCATTTTGCGGGAAGAGGAGGCTCTGTACCTGCAGTGCTGCTTTTCTTGCC
TAGACTCTAGGAACTATCCGAGCTCCACTCCCCACAACATACTCAAAGGAACGGAGAGAACCGGGACCCCCCTGCGGGGACCCGGAACTG
ATCTGACAGGATGGCATCTGATGACTTTGACATAGTGATTGAGGCCATGCTGGAAGCTCCCTATAAAAAAGAAGAGGATGAGCAACAAAG
GAAAGAAGTTAAAAAGGATTATCCTAGCAATACCACCAGCAGCACCAGCAACAGTGGCAATGAGACCAGTGGAAGCAGCACCATCGGGGA
GACAAGCAATCGTAGTCGAGATCGGGATCGGTATAGACGGAGAAATAGTCGGAGCCGAAGTCCAGGTCGGCAGTGTCGTCACCGTAGCCG
TAGCTGGGATCGTCGACATGGTAGTGAGTCGCGAAGTCGGGACCATCGTCGTGAGGATCGTGTGCATTACAGGAGTCCTCCACTTGCCAC
TGGTTCCGCCATGGAGTCATAGTTGCAGCTGACTCCAGGGCTACAGCGGGTGCTTACATTGCCTCCCAGACGGTGAAGAAGGTGATAGAG
ATCAACCCATACCTGCTAGGCACCATGGCTGGGGGCGCAGCGGATTGCAGCTTCTGGGAACGGCTGTTGGCTCGGCAATGTCGAATCTAT
GAGCTTCGAAATAAGGAACGCATCTCTGTAGCAGCTGCCTCCAAACTGCTTGCCAACATGGTGTATCAGTACAAAGGCATGGGGCTGTCC
ATGGGCACCATGATCTGTGGCTGGGATAAGAGAGGCCCTGGCCTCTACTACGTGGACAGTGAAGGGAACCGGATTTCAGGGGCCACCTTC
TCTGTAGGTTCTGGCTCTGTGTATGCATATGGGGTCATGGATCGGGGCTATTCCTATGACCTGGAAGTGGAGCAGGCCTATGATCTGGCC
CGTCGAGCCATCTACCAAGCCACCTACAGAGATGCCTACTCAGGAGGTGCAGTCAACCTCTACCACGTGCGGGAGGATGGCTGGATCCGA
GTCTCCAGTGACAATGTGGCTGATCTACATGAGAAGTATAGTGGCTCTACCCCCTGAAAGAGGGTGGATGCAGCTGCTTGTGTTTCTTGG
GGTGACTGTCATTGGTAATACGGACACAGTGACCCATCCTCCATCCTATTTATAGTGGAAGGGCCTTCAATTGTATCAGTACTTTTTTTT
AAGCTCTGGCACATTGACCTCTATGTGTTACCAGTCATTAATGAGCTGCTGCAGAGGTGACTATTTGTTTTACTTTCTTGGATGTTAACA

>72814_72814_1_RBM23-PSMB5_RBM23_chr14_23375404_ENST00000346528_PSMB5_chr14_23502883_ENST00000361611_length(amino acids)=164AA_BP=
MLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGS

--------------------------------------------------------------
>72814_72814_2_RBM23-PSMB5_RBM23_chr14_23375404_ENST00000346528_PSMB5_chr14_23502883_ENST00000493471_length(transcript)=1453nt_BP=543nt
GCAGATTGGGGAAGGTTCTGGAAGACGGCAGAGCTGCCGCCATTTTGCGGGAAGAGGAGGCTCTGTACCTGCAGTGCTGCTTTTCTTGCC
TAGACTCTAGGAACTATCCGAGCTCCACTCCCCACAACATACTCAAAGGAACGGAGAGAACCGGGACCCCCCTGCGGGGACCCGGAACTG
ATCTGACAGGATGGCATCTGATGACTTTGACATAGTGATTGAGGCCATGCTGGAAGCTCCCTATAAAAAAGAAGAGGATGAGCAACAAAG
GAAAGAAGTTAAAAAGGATTATCCTAGCAATACCACCAGCAGCACCAGCAACAGTGGCAATGAGACCAGTGGAAGCAGCACCATCGGGGA
GACAAGCAATCGTAGTCGAGATCGGGATCGGTATAGACGGAGAAATAGTCGGAGCCGAAGTCCAGGTCGGCAGTGTCGTCACCGTAGCCG
TAGCTGGGATCGTCGACATGGTAGTGAGTCGCGAAGTCGGGACCATCGTCGTGAGGATCGTGTGCATTACAGGAGTCCTCCACTTGCCAC
TGGTTCCGCCATGGAGTCATAGTTGCAGCTGACTCCAGGGCTACAGCGGGTGCTTACATTGCCTCCCAGACGGTGAAGAAGGTGATAGAG
ATCAACCCATACCTGCTAGGCACCATGGCTGGGGGCGCAGCGGATTGCAGCTTCTGGGAACGGCTGTTGGCTCGGCAATGTCGAATCTAT
GAGCTTCGAAATAAGGAACGCATCTCTGTAGCAGCTGCCTCCAAACTGCTTGCCAACATGGTGTATCAGTACAAAGGCATGGGGCTGTCC
ATGGGCACCATGATCTGTGGCTGGGATAAGAGAGGCCCTGTGTCTGAAGTTCTGTGCTTGAAACCTAAGTCATTTGGAATGTACTTGTTT
TGTGGGTGTGCTGAGAGGATCGGCAACATGGCAAGGCCTCTACTACGTGGACAGTGAAGGGAACCGGATTTCAGGGGCCACCTTCTCTGT
AGGTTCTGGCTCTGTGTATGCATATGGGGTCATGGATCGGGGCTATTCCTATGACCTGGAAGTGGAGCAGGCCTATGATCTGGCCCGTCG
AGCCATCTACCAAGCCACCTACAGAGATGCCTACTCAGGAGGTGCAGTCAACCTCTACCACGTGCGGGAGGATGGCTGGATCCGAGTCTC
CAGTGACAATGTGGCTGATCTACATGAGAAGTATAGTGGCTCTACCCCCTGAAAGAGGGTGGATGCAGCTGCTTGTGTTTCTTGGGGTGA
CTGTCATTGGTAATACGGACACAGTGACCCATCCTCCATCCTATTTATAGTGGAAGGGCCTTCAATTGTATCAGTACTTTTTTTTAAGCT
CTGGCACATTGACCTCTATGTGTTACCAGTCATTAATGAGCTGCTGCAGAGGTGACTATTTGTTTTACTTTCTTGGATGTTAACATTACA

>72814_72814_2_RBM23-PSMB5_RBM23_chr14_23375404_ENST00000346528_PSMB5_chr14_23502883_ENST00000493471_length(amino acids)=137AA_BP=
MHTILTTMVPTSRLTTMSTIPATATVTTLPTWTSAPTISPSIPIPISTTIACLPDGAASTGLIATVAGAAGGIARIILFNFFPLLLILFF

--------------------------------------------------------------
>72814_72814_3_RBM23-PSMB5_RBM23_chr14_23375404_ENST00000359890_PSMB5_chr14_23502883_ENST00000361611_length(transcript)=1429nt_BP=597nt
GCATGCGCAGATTGGGGAAGGTTCTGGAAGACGGCAGAGCTGCCGCCATTTTGCGGGAAGAGGAGGCTCTGTACCTGCAGTGCTGCTTTT
CTTGCCTAGACTCTAGGAACTATCCGAGCTCCACTCCCCACAACATACTCAAAGGAACGGAGAGAACCGGGACCCCCCTGCGGGGACCCG
GAACTGATCTGACAGGATGGCATCTGATGACTTTGACATAGTGATTGAGGCCATGCTGGAAGCTCCCTATAAAAAAGAAGAGGATGAGCA
ACAAAGGAAAGAAGTTAAAAAGGATTATCCTAGCAATACCACCAGCAGCACCAGCAACAGTGGCAATGAGACCAGTGGAAGCAGCACCAT
CGGGGAGACAAGCAAGAAGAAGAGGAGTCGGAGCCATAATAAAAGCAGGGATAGAAAGCGCAGTCGTAGTCGAGATCGGGATCGGTATAG
ACGGAGAAATAGTCGGAGCCGAAGTCCAGGTCGGCAGTGTCGTCACCGTAGCCGTAGCTGGGATCGTCGACATGGTAGTGAGTCGCGAAG
TCGGGACCATCGTCGTGAGGATCGTGTGCATTACAGGAGTCCTCCACTTGCCACTGGTTCCGCCATGGAGTCATAGTTGCAGCTGACTCC
AGGGCTACAGCGGGTGCTTACATTGCCTCCCAGACGGTGAAGAAGGTGATAGAGATCAACCCATACCTGCTAGGCACCATGGCTGGGGGC
GCAGCGGATTGCAGCTTCTGGGAACGGCTGTTGGCTCGGCAATGTCGAATCTATGAGCTTCGAAATAAGGAACGCATCTCTGTAGCAGCT
GCCTCCAAACTGCTTGCCAACATGGTGTATCAGTACAAAGGCATGGGGCTGTCCATGGGCACCATGATCTGTGGCTGGGATAAGAGAGGC
CCTGGCCTCTACTACGTGGACAGTGAAGGGAACCGGATTTCAGGGGCCACCTTCTCTGTAGGTTCTGGCTCTGTGTATGCATATGGGGTC
ATGGATCGGGGCTATTCCTATGACCTGGAAGTGGAGCAGGCCTATGATCTGGCCCGTCGAGCCATCTACCAAGCCACCTACAGAGATGCC
TACTCAGGAGGTGCAGTCAACCTCTACCACGTGCGGGAGGATGGCTGGATCCGAGTCTCCAGTGACAATGTGGCTGATCTACATGAGAAG
TATAGTGGCTCTACCCCCTGAAAGAGGGTGGATGCAGCTGCTTGTGTTTCTTGGGGTGACTGTCATTGGTAATACGGACACAGTGACCCA
TCCTCCATCCTATTTATAGTGGAAGGGCCTTCAATTGTATCAGTACTTTTTTTTAAGCTCTGGCACATTGACCTCTATGTGTTACCAGTC

>72814_72814_3_RBM23-PSMB5_RBM23_chr14_23375404_ENST00000359890_PSMB5_chr14_23502883_ENST00000361611_length(amino acids)=164AA_BP=
MLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGS

--------------------------------------------------------------
>72814_72814_4_RBM23-PSMB5_RBM23_chr14_23375404_ENST00000359890_PSMB5_chr14_23502883_ENST00000493471_length(transcript)=1507nt_BP=597nt
GCATGCGCAGATTGGGGAAGGTTCTGGAAGACGGCAGAGCTGCCGCCATTTTGCGGGAAGAGGAGGCTCTGTACCTGCAGTGCTGCTTTT
CTTGCCTAGACTCTAGGAACTATCCGAGCTCCACTCCCCACAACATACTCAAAGGAACGGAGAGAACCGGGACCCCCCTGCGGGGACCCG
GAACTGATCTGACAGGATGGCATCTGATGACTTTGACATAGTGATTGAGGCCATGCTGGAAGCTCCCTATAAAAAAGAAGAGGATGAGCA
ACAAAGGAAAGAAGTTAAAAAGGATTATCCTAGCAATACCACCAGCAGCACCAGCAACAGTGGCAATGAGACCAGTGGAAGCAGCACCAT
CGGGGAGACAAGCAAGAAGAAGAGGAGTCGGAGCCATAATAAAAGCAGGGATAGAAAGCGCAGTCGTAGTCGAGATCGGGATCGGTATAG
ACGGAGAAATAGTCGGAGCCGAAGTCCAGGTCGGCAGTGTCGTCACCGTAGCCGTAGCTGGGATCGTCGACATGGTAGTGAGTCGCGAAG
TCGGGACCATCGTCGTGAGGATCGTGTGCATTACAGGAGTCCTCCACTTGCCACTGGTTCCGCCATGGAGTCATAGTTGCAGCTGACTCC
AGGGCTACAGCGGGTGCTTACATTGCCTCCCAGACGGTGAAGAAGGTGATAGAGATCAACCCATACCTGCTAGGCACCATGGCTGGGGGC
GCAGCGGATTGCAGCTTCTGGGAACGGCTGTTGGCTCGGCAATGTCGAATCTATGAGCTTCGAAATAAGGAACGCATCTCTGTAGCAGCT
GCCTCCAAACTGCTTGCCAACATGGTGTATCAGTACAAAGGCATGGGGCTGTCCATGGGCACCATGATCTGTGGCTGGGATAAGAGAGGC
CCTGTGTCTGAAGTTCTGTGCTTGAAACCTAAGTCATTTGGAATGTACTTGTTTTGTGGGTGTGCTGAGAGGATCGGCAACATGGCAAGG
CCTCTACTACGTGGACAGTGAAGGGAACCGGATTTCAGGGGCCACCTTCTCTGTAGGTTCTGGCTCTGTGTATGCATATGGGGTCATGGA
TCGGGGCTATTCCTATGACCTGGAAGTGGAGCAGGCCTATGATCTGGCCCGTCGAGCCATCTACCAAGCCACCTACAGAGATGCCTACTC
AGGAGGTGCAGTCAACCTCTACCACGTGCGGGAGGATGGCTGGATCCGAGTCTCCAGTGACAATGTGGCTGATCTACATGAGAAGTATAG
TGGCTCTACCCCCTGAAAGAGGGTGGATGCAGCTGCTTGTGTTTCTTGGGGTGACTGTCATTGGTAATACGGACACAGTGACCCATCCTC
CATCCTATTTATAGTGGAAGGGCCTTCAATTGTATCAGTACTTTTTTTTAAGCTCTGGCACATTGACCTCTATGTGTTACCAGTCATTAA

>72814_72814_4_RBM23-PSMB5_RBM23_chr14_23375404_ENST00000359890_PSMB5_chr14_23502883_ENST00000493471_length(amino acids)=153AA_BP=
MHTILTTMVPTSRLTTMSTIPATATVTTLPTWTSAPTISPSIPIPISTTTALSIPAFIMAPTPLLLACLPDGAASTGLIATVAGAAGGIA

--------------------------------------------------------------
>72814_72814_5_RBM23-PSMB5_RBM23_chr14_23375404_ENST00000399922_PSMB5_chr14_23502883_ENST00000361611_length(transcript)=1379nt_BP=547nt
ATGCGCAGATTGGGGAAGGTTCTGGAAGACGGCAGAGCTGCCGCCATTTTGCGGGAAGAGGAGGCTCTGTACCTGCAGTGCTGCTTTTCT
TGCCTAGACTCTAGGAACTATCCGAGCTCCACTCCCCACAACATACTCAAAGGAACGGAGAGAACCGGGACCCCCCTGCGGGGACCCGGA
ACTGATCTGACAGGATGGCATCTGATGACTTTGACATAGTGATTGAGGCCATGCTGGAAGCTCCCTATAAAAAAGAAGAGGATGAGCAAC
AAAGGAAAGAAGTTAAAAAGGATTATCCTAGCAATACCACCAGCAGCACCAGCAACAGTGGCAATGAGACCAGTGGAAGCAGCACCATCG
GGGAGACAAGCAATCGTAGTCGAGATCGGGATCGGTATAGACGGAGAAATAGTCGGAGCCGAAGTCCAGGTCGGCAGTGTCGTCACCGTA
GCCGTAGCTGGGATCGTCGACATGGTAGTGAGTCGCGAAGTCGGGACCATCGTCGTGAGGATCGTGTGCATTACAGGAGTCCTCCACTTG
CCACTGGTTCCGCCATGGAGTCATAGTTGCAGCTGACTCCAGGGCTACAGCGGGTGCTTACATTGCCTCCCAGACGGTGAAGAAGGTGAT
AGAGATCAACCCATACCTGCTAGGCACCATGGCTGGGGGCGCAGCGGATTGCAGCTTCTGGGAACGGCTGTTGGCTCGGCAATGTCGAAT
CTATGAGCTTCGAAATAAGGAACGCATCTCTGTAGCAGCTGCCTCCAAACTGCTTGCCAACATGGTGTATCAGTACAAAGGCATGGGGCT
GTCCATGGGCACCATGATCTGTGGCTGGGATAAGAGAGGCCCTGGCCTCTACTACGTGGACAGTGAAGGGAACCGGATTTCAGGGGCCAC
CTTCTCTGTAGGTTCTGGCTCTGTGTATGCATATGGGGTCATGGATCGGGGCTATTCCTATGACCTGGAAGTGGAGCAGGCCTATGATCT
GGCCCGTCGAGCCATCTACCAAGCCACCTACAGAGATGCCTACTCAGGAGGTGCAGTCAACCTCTACCACGTGCGGGAGGATGGCTGGAT
CCGAGTCTCCAGTGACAATGTGGCTGATCTACATGAGAAGTATAGTGGCTCTACCCCCTGAAAGAGGGTGGATGCAGCTGCTTGTGTTTC
TTGGGGTGACTGTCATTGGTAATACGGACACAGTGACCCATCCTCCATCCTATTTATAGTGGAAGGGCCTTCAATTGTATCAGTACTTTT
TTTTAAGCTCTGGCACATTGACCTCTATGTGTTACCAGTCATTAATGAGCTGCTGCAGAGGTGACTATTTGTTTTACTTTCTTGGATGTT

>72814_72814_5_RBM23-PSMB5_RBM23_chr14_23375404_ENST00000399922_PSMB5_chr14_23502883_ENST00000361611_length(amino acids)=164AA_BP=
MLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGS

--------------------------------------------------------------
>72814_72814_6_RBM23-PSMB5_RBM23_chr14_23375404_ENST00000399922_PSMB5_chr14_23502883_ENST00000493471_length(transcript)=1457nt_BP=547nt
ATGCGCAGATTGGGGAAGGTTCTGGAAGACGGCAGAGCTGCCGCCATTTTGCGGGAAGAGGAGGCTCTGTACCTGCAGTGCTGCTTTTCT
TGCCTAGACTCTAGGAACTATCCGAGCTCCACTCCCCACAACATACTCAAAGGAACGGAGAGAACCGGGACCCCCCTGCGGGGACCCGGA
ACTGATCTGACAGGATGGCATCTGATGACTTTGACATAGTGATTGAGGCCATGCTGGAAGCTCCCTATAAAAAAGAAGAGGATGAGCAAC
AAAGGAAAGAAGTTAAAAAGGATTATCCTAGCAATACCACCAGCAGCACCAGCAACAGTGGCAATGAGACCAGTGGAAGCAGCACCATCG
GGGAGACAAGCAATCGTAGTCGAGATCGGGATCGGTATAGACGGAGAAATAGTCGGAGCCGAAGTCCAGGTCGGCAGTGTCGTCACCGTA
GCCGTAGCTGGGATCGTCGACATGGTAGTGAGTCGCGAAGTCGGGACCATCGTCGTGAGGATCGTGTGCATTACAGGAGTCCTCCACTTG
CCACTGGTTCCGCCATGGAGTCATAGTTGCAGCTGACTCCAGGGCTACAGCGGGTGCTTACATTGCCTCCCAGACGGTGAAGAAGGTGAT
AGAGATCAACCCATACCTGCTAGGCACCATGGCTGGGGGCGCAGCGGATTGCAGCTTCTGGGAACGGCTGTTGGCTCGGCAATGTCGAAT
CTATGAGCTTCGAAATAAGGAACGCATCTCTGTAGCAGCTGCCTCCAAACTGCTTGCCAACATGGTGTATCAGTACAAAGGCATGGGGCT
GTCCATGGGCACCATGATCTGTGGCTGGGATAAGAGAGGCCCTGTGTCTGAAGTTCTGTGCTTGAAACCTAAGTCATTTGGAATGTACTT
GTTTTGTGGGTGTGCTGAGAGGATCGGCAACATGGCAAGGCCTCTACTACGTGGACAGTGAAGGGAACCGGATTTCAGGGGCCACCTTCT
CTGTAGGTTCTGGCTCTGTGTATGCATATGGGGTCATGGATCGGGGCTATTCCTATGACCTGGAAGTGGAGCAGGCCTATGATCTGGCCC
GTCGAGCCATCTACCAAGCCACCTACAGAGATGCCTACTCAGGAGGTGCAGTCAACCTCTACCACGTGCGGGAGGATGGCTGGATCCGAG
TCTCCAGTGACAATGTGGCTGATCTACATGAGAAGTATAGTGGCTCTACCCCCTGAAAGAGGGTGGATGCAGCTGCTTGTGTTTCTTGGG
GTGACTGTCATTGGTAATACGGACACAGTGACCCATCCTCCATCCTATTTATAGTGGAAGGGCCTTCAATTGTATCAGTACTTTTTTTTA
AGCTCTGGCACATTGACCTCTATGTGTTACCAGTCATTAATGAGCTGCTGCAGAGGTGACTATTTGTTTTACTTTCTTGGATGTTAACAT

>72814_72814_6_RBM23-PSMB5_RBM23_chr14_23375404_ENST00000399922_PSMB5_chr14_23502883_ENST00000493471_length(amino acids)=137AA_BP=
MHTILTTMVPTSRLTTMSTIPATATVTTLPTWTSAPTISPSIPIPISTTIACLPDGAASTGLIATVAGAAGGIARIILFNFFPLLLILFF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RBM23-PSMB5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RBM23-PSMB5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RBM23-PSMB5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source