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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:RBM39-WFDC13 (FusionGDB2 ID:72889) |
Fusion Gene Summary for RBM39-WFDC13 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RBM39-WFDC13 | Fusion gene ID: 72889 | Hgene | Tgene | Gene symbol | RBM39 | WFDC13 | Gene ID | 9584 | 164237 |
| Gene name | RNA binding motif protein 39 | WAP four-disulfide core domain 13 | |
| Synonyms | CAPER|CAPERalpha|FSAP59|HCC1|RNPC2 | C20orf138|WAP13|dJ601O1.3 | |
| Cytomap | 20q11.22 | 20q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein 39CAPER alphaRNA-binding region (RNP1, RRM) containing 2coactivator of activating protein-1 and estrogen receptorsepididymis secretory sperm binding proteinfunctional spliceosome-associated protein 59hepatocellular carcinoma prot | WAP four-disulfide core domain protein 13protease inhibitor WAP13protein WFDC13 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000253363, ENST00000361162, ENST00000407261, ENST00000528062, ENST00000397370, ENST00000463098, | ENST00000305479, | |
| Fusion gene scores | * DoF score | 17 X 20 X 10=3400 | 2 X 1 X 2=4 |
| # samples | 23 | 3 | |
| ** MAII score | log2(23/3400*10)=-3.88582898008069 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/4*10)=2.90689059560852 | |
| Context | PubMed: RBM39 [Title/Abstract] AND WFDC13 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | RBM39(34300941)-WFDC13(44333083), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across RBM39 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across WFDC13 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-EJ-5514-01A | RBM39 | chr20 | 34300941 | - | WFDC13 | chr20 | 44333083 | + |
| ChimerDB4 | PRAD | TCGA-EJ-5514 | RBM39 | chr20 | 34300941 | - | WFDC13 | chr20 | 44333083 | + |
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Fusion Gene ORF analysis for RBM39-WFDC13 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000253363 | ENST00000305479 | RBM39 | chr20 | 34300941 | - | WFDC13 | chr20 | 44333083 | + |
| In-frame | ENST00000361162 | ENST00000305479 | RBM39 | chr20 | 34300941 | - | WFDC13 | chr20 | 44333083 | + |
| In-frame | ENST00000407261 | ENST00000305479 | RBM39 | chr20 | 34300941 | - | WFDC13 | chr20 | 44333083 | + |
| In-frame | ENST00000528062 | ENST00000305479 | RBM39 | chr20 | 34300941 | - | WFDC13 | chr20 | 44333083 | + |
| intron-3CDS | ENST00000397370 | ENST00000305479 | RBM39 | chr20 | 34300941 | - | WFDC13 | chr20 | 44333083 | + |
| intron-3CDS | ENST00000463098 | ENST00000305479 | RBM39 | chr20 | 34300941 | - | WFDC13 | chr20 | 44333083 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000253363 | RBM39 | chr20 | 34300941 | - | ENST00000305479 | WFDC13 | chr20 | 44333083 | + | 2374 | 1198 | 24 | 1391 | 455 |
| ENST00000361162 | RBM39 | chr20 | 34300941 | - | ENST00000305479 | WFDC13 | chr20 | 44333083 | + | 2735 | 1559 | 385 | 1752 | 455 |
| ENST00000528062 | RBM39 | chr20 | 34300941 | - | ENST00000305479 | WFDC13 | chr20 | 44333083 | + | 2595 | 1419 | 311 | 1612 | 433 |
| ENST00000407261 | RBM39 | chr20 | 34300941 | - | ENST00000305479 | WFDC13 | chr20 | 44333083 | + | 2751 | 1575 | 473 | 1768 | 431 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000253363 | ENST00000305479 | RBM39 | chr20 | 34300941 | - | WFDC13 | chr20 | 44333083 | + | 0.00493387 | 0.99506605 |
| ENST00000361162 | ENST00000305479 | RBM39 | chr20 | 34300941 | - | WFDC13 | chr20 | 44333083 | + | 0.00585898 | 0.99414104 |
| ENST00000528062 | ENST00000305479 | RBM39 | chr20 | 34300941 | - | WFDC13 | chr20 | 44333083 | + | 0.003705869 | 0.9962941 |
| ENST00000407261 | ENST00000305479 | RBM39 | chr20 | 34300941 | - | WFDC13 | chr20 | 44333083 | + | 0.00871741 | 0.9912826 |
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Fusion Genomic Features for RBM39-WFDC13 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| RBM39 | chr20 | 34300940 | - | WFDC13 | chr20 | 44333082 | + | 0.000465153 | 0.99953485 |
| RBM39 | chr20 | 34300940 | - | WFDC13 | chr20 | 44333082 | + | 0.000465153 | 0.99953485 |
| RBM39 | chr20 | 34300940 | - | WFDC13 | chr20 | 44333082 | + | 0.000465153 | 0.99953485 |
| RBM39 | chr20 | 34300940 | - | WFDC13 | chr20 | 44333082 | + | 0.000465153 | 0.99953485 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RBM39-WFDC13 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:34300941/chr20:44333083) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000253363 | - | 12 | 17 | 41_90 | 391 | 531.0 | Compositional bias | Note=Arg/Ser-rich (RS domain) |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000361162 | - | 12 | 17 | 41_90 | 391 | 525.0 | Compositional bias | Note=Arg/Ser-rich (RS domain) |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000528062 | - | 11 | 16 | 41_90 | 369 | 509.0 | Compositional bias | Note=Arg/Ser-rich (RS domain) |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000253363 | - | 12 | 17 | 153_230 | 391 | 531.0 | Domain | RRM 1 |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000253363 | - | 12 | 17 | 250_328 | 391 | 531.0 | Domain | RRM 2 |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000361162 | - | 12 | 17 | 153_230 | 391 | 525.0 | Domain | RRM 1 |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000361162 | - | 12 | 17 | 250_328 | 391 | 525.0 | Domain | RRM 2 |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000528062 | - | 11 | 16 | 153_230 | 369 | 509.0 | Domain | RRM 1 |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000528062 | - | 11 | 16 | 250_328 | 369 | 509.0 | Domain | RRM 2 |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000253363 | - | 12 | 17 | 291_355 | 391 | 531.0 | Region | Activating domain |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000361162 | - | 12 | 17 | 291_355 | 391 | 525.0 | Region | Activating domain |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000528062 | - | 11 | 16 | 291_355 | 369 | 509.0 | Region | Activating domain |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000253363 | - | 12 | 17 | 409_416 | 391 | 531.0 | Compositional bias | Note=Poly-Ala |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000361162 | - | 12 | 17 | 409_416 | 391 | 525.0 | Compositional bias | Note=Poly-Ala |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000528062 | - | 11 | 16 | 409_416 | 369 | 509.0 | Compositional bias | Note=Poly-Ala |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000253363 | - | 12 | 17 | 445_508 | 391 | 531.0 | Domain | RRM 3 |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000361162 | - | 12 | 17 | 445_508 | 391 | 525.0 | Domain | RRM 3 |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000528062 | - | 11 | 16 | 445_508 | 369 | 509.0 | Domain | RRM 3 |
| Tgene | WFDC13 | chr20:34300941 | chr20:44333083 | ENST00000305479 | 0 | 4 | 24_73 | 29 | 348.6666666666667 | Domain | Note=WAP%3B atypical |
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Fusion Gene Sequence for RBM39-WFDC13 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >72889_72889_1_RBM39-WFDC13_RBM39_chr20_34300941_ENST00000253363_WFDC13_chr20_44333083_ENST00000305479_length(transcript)=2374nt_BP=1198nt GGCCGGAACAGGCGTTTAGAGAAAATGGCAGACGATATTGATATTGAAGCAATGCTTGAGGCTCCTTACAAGAAGGATGAGAACAAGTTG AGCAGTGCCAACGGCCATGAAGAACGTAGCAAAAAGAGGAAAAAAAGCAAGAGCAGAAGTCGTAGTCATGAACGAAAGAGAAGCAAAAGT AAGGAACGGAAGCGAAGTAGAGACAGAGAAAGGAAAAAGAGCAAAAGCCGTGAAAGAAAGCGAAGTAGAAGCAAAGAGAGGCGACGGAGC CGCTCAAGAAGTCGAGATCGAAGATTTAGAGGCCGCTACAGAAGTCCTTACTCCGGACCAAAATTTAACAGTGCCATCCGAGGAAAGATT GGGTTGCCTCATAGCATCAAATTAAGCAGACGACGTTCCCGAAGCAAAAGTCCATTCAGAAAAGACAAGAGCCCTGTGAGAGAACCTATT GATAATTTAACTCCTGAGGAAAGAGATGCAAGGACAGTCTTCTGTATGCAGCTGGCGGCAAGAATTCGACCAAGGGATTTGGAAGAGTTT TTCTCTACAGTAGGAAAGGTTCGAGATGTGAGGATGATTTCTGACAGAAATTCAAGACGTTCCAAAGGAATTGCTTATGTGGAGTTCGTC GATGTTAGCTCAGTGCCTCTAGCAATAGGATTAACTGGCCAACGAGTTTTAGGCGTGCCAATCATAGTACAGGCATCACAGGCAGAAAAA AACAGAGCTGCAGCAATGGCAAACAATTTACAAAAGGGAAGTGCTGGACCTATGAGGCTTTATGTGGGCTCATTACACTTCAACATAACT GAAGATATGCTTCGTGGGATCTTTGAGCCTTTTGGAAGAATTGAAAGTATCCAGCTGATGATGGACAGTGAAACTGGTCGATCCAAGGGA TATGGATTTATTACATTTTCTGACTCAGAATGTGCCAAAAAGGCTTTGGAACAACTTAATGGATTTGAACTAGCAGGAAGACCAATGAAA GTTGGTCATGTTACTGAACGTACTGATGCTTCGAGTGCTAGTTCATTTTTGGACAGTGATGAACTGGAAAGGACTGGAATTGATTTGGGA ACAACTGGTCGTCTTCAGTTAATGGCAAGACTTGCAGAGGGTACAGGTTTGCAGATTCCGCCAGCAGCACAGCAAGCTCTACAGATGAGT GGCTCTTTGGCATTTGGTGCTGTGGCAGAGTATATCTTGGAACCTCCACCCTGCATATCAGCACCTGAAAACTGTACTCACCTGTGTACA ATGCAGGAAGATTGCGAGAAAGGATTTCAGTGCTGTTCCTCCTTCTGTGGGATAGTCTGTTCATCAGAAACATTTCAAAAGCGCAACAGA ATCAAACACAAGGGCTCAGAAGTCATCATGCCTGCCAACTGAGGCATATTTCCTAGATCATTTTGCCTCTACGATGTTTTTTCTTGGTCC ACCTTTAGGAAGGTATTGAGAAGCAAGAAACTGGAGGCCCAATATCTAACCTGCAAATCGTTTTTGAGTTTGGCAATAAAGGCTAATCTA CCATAAAACTCTTGAAGCTTAAGCTTTAGGTCAACACTTGCAAGAGCCCCTTCCAAAGCTCAGCACAGTTTCCTCCTGGGATGAGGAGAG GAATCAGAAACCCCACTTTGGCATAGAGACAAGCAGCACTGTTCCAGTCCAGGGATGCTGTGTGTGCCCTGGTGGTGGTCTTAAGGACCT ACCACATCAACATCTGGACAACCCTCACTGATTACCTGCCCTTGGTTGCACTCATCAGGCTAATTGATCCCATATTTAACCTCAAGGAGA AATATCAACCAGACACTGCATGGCAACCTCCTTGGGGCCAGCCTTCAAGGCTTCATGGCCATATCATGAACCCAGGACAGGCACAGTGGG GGTGGTGAGGACCTGATAGAGTTGGATCAGTGACTAAGAGGCTGCAATAAGGTGCCATGAAATCAAAATCAAAGGGCTAGAACTCTCCAA GGTCTTGCCCCCGGCATGTAGCACCACCTGAGCCAGAAACTGCAGAGGACATGACAGTGTGGCATTACTGATAAGTTATGGAAATGGAAA TAATCTTTCCTAAACTACCAATAATAACTTTAAATTTTTGATCAACCATGCTAGAGCAAAGATTGAATTATCCTTCTGTTCTCTCTACAG AAATGATATAAAAACTATAGTCATAAGAAGAGACAATCAAAAATAATCAGCCATAAAATATTAAAAAGGTATTATAAAGGTATTTAAAAT AATAATAATAAAGTGTTATTTTCCTGGGATTCATGATATTTGATATATTCGTAAGCTTTTGTTAAGTTTGTAATTTGTTGCAATTTCTTT >72889_72889_1_RBM39-WFDC13_RBM39_chr20_34300941_ENST00000253363_WFDC13_chr20_44333083_ENST00000305479_length(amino acids)=455AA_BP=382 MADDIDIEAMLEAPYKKDENKLSSANGHEERSKKRKKSKSRSRSHERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRR FRGRYRSPYSGPKFNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVR DVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIF EPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLM ARLAEGTGLQIPPAAQQALQMSGSLAFGAVAEYILEPPPCISAPENCTHLCTMQEDCEKGFQCCSSFCGIVCSSETFQKRNRIKHKGSEV -------------------------------------------------------------- >72889_72889_2_RBM39-WFDC13_RBM39_chr20_34300941_ENST00000361162_WFDC13_chr20_44333083_ENST00000305479_length(transcript)=2735nt_BP=1559nt GCGAGAGCCCGTGCTGAGGGCTCTGTGAGGCCCCGTGTGTTTGTGTGTGTGTATGTGTGCTGGTGAATGTGAGTACAGGGAAGCAGCGGC CGCCATTTCAGGGAGCTTGTCGACGCTGTCGCAGGGGTGGATCCTGAGCTGCCGAAGCCGCCGTCCTGCTCTCCCGCGTGGGCTTCTCTA ATTCCATTGTTTTTTTTAGATTCTCTCGGGCCTAGCCGTCCTTGGAACCCGATATTCGGGCTGGGCGGTTCCGCGGCCTGGGCCTAGGGG CTTAACAGTAGCAACAGAAGCGGCGGCGGCGGCAGCAGCAGCAGCAGCAGCAGCAATCTCTTCCCGAACACGAGCACCACAGGCGCCCGA AGGCCGGAACAGGCGTTTAGAGAAAATGGCAGACGATATTGATATTGAAGCAATGCTTGAGGCTCCTTACAAGAAGGATGAGAACAAGTT GAGCAGTGCCAACGGCCATGAAGAACGTAGCAAAAAGAGGAAAAAAAGCAAGAGCAGAAGTCGTAGTCATGAACGAAAGAGAAGCAAAAG TAAGGAACGGAAGCGAAGTAGAGACAGAGAAAGGAAAAAGAGCAAAAGCCGTGAAAGAAAGCGAAGTAGAAGCAAAGAGAGGCGACGGAG CCGCTCAAGAAGTCGAGATCGAAGATTTAGAGGCCGCTACAGAAGTCCTTACTCCGGACCAAAATTTAACAGTGCCATCCGAGGAAAGAT TGGGTTGCCTCATAGCATCAAATTAAGCAGACGACGTTCCCGAAGCAAAAGTCCATTCAGAAAAGACAAGAGCCCTGTGAGAGAACCTAT TGATAATTTAACTCCTGAGGAAAGAGATGCAAGGACAGTCTTCTGTATGCAGCTGGCGGCAAGAATTCGACCAAGGGATTTGGAAGAGTT TTTCTCTACAGTAGGAAAGGTTCGAGATGTGAGGATGATTTCTGACAGAAATTCAAGACGTTCCAAAGGAATTGCTTATGTGGAGTTCGT CGATGTTAGCTCAGTGCCTCTAGCAATAGGATTAACTGGCCAACGAGTTTTAGGCGTGCCAATCATAGTACAGGCATCACAGGCAGAAAA AAACAGAGCTGCAGCAATGGCAAACAATTTACAAAAGGGAAGTGCTGGACCTATGAGGCTTTATGTGGGCTCATTACACTTCAACATAAC TGAAGATATGCTTCGTGGGATCTTTGAGCCTTTTGGAAGAATTGAAAGTATCCAGCTGATGATGGACAGTGAAACTGGTCGATCCAAGGG ATATGGATTTATTACATTTTCTGACTCAGAATGTGCCAAAAAGGCTTTGGAACAACTTAATGGATTTGAACTAGCAGGAAGACCAATGAA AGTTGGTCATGTTACTGAACGTACTGATGCTTCGAGTGCTAGTTCATTTTTGGACAGTGATGAACTGGAAAGGACTGGAATTGATTTGGG AACAACTGGTCGTCTTCAGTTAATGGCAAGACTTGCAGAGGGTACAGGTTTGCAGATTCCGCCAGCAGCACAGCAAGCTCTACAGATGAG TGGCTCTTTGGCATTTGGTGCTGTGGCAGAGTATATCTTGGAACCTCCACCCTGCATATCAGCACCTGAAAACTGTACTCACCTGTGTAC AATGCAGGAAGATTGCGAGAAAGGATTTCAGTGCTGTTCCTCCTTCTGTGGGATAGTCTGTTCATCAGAAACATTTCAAAAGCGCAACAG AATCAAACACAAGGGCTCAGAAGTCATCATGCCTGCCAACTGAGGCATATTTCCTAGATCATTTTGCCTCTACGATGTTTTTTCTTGGTC CACCTTTAGGAAGGTATTGAGAAGCAAGAAACTGGAGGCCCAATATCTAACCTGCAAATCGTTTTTGAGTTTGGCAATAAAGGCTAATCT ACCATAAAACTCTTGAAGCTTAAGCTTTAGGTCAACACTTGCAAGAGCCCCTTCCAAAGCTCAGCACAGTTTCCTCCTGGGATGAGGAGA GGAATCAGAAACCCCACTTTGGCATAGAGACAAGCAGCACTGTTCCAGTCCAGGGATGCTGTGTGTGCCCTGGTGGTGGTCTTAAGGACC TACCACATCAACATCTGGACAACCCTCACTGATTACCTGCCCTTGGTTGCACTCATCAGGCTAATTGATCCCATATTTAACCTCAAGGAG AAATATCAACCAGACACTGCATGGCAACCTCCTTGGGGCCAGCCTTCAAGGCTTCATGGCCATATCATGAACCCAGGACAGGCACAGTGG GGGTGGTGAGGACCTGATAGAGTTGGATCAGTGACTAAGAGGCTGCAATAAGGTGCCATGAAATCAAAATCAAAGGGCTAGAACTCTCCA AGGTCTTGCCCCCGGCATGTAGCACCACCTGAGCCAGAAACTGCAGAGGACATGACAGTGTGGCATTACTGATAAGTTATGGAAATGGAA ATAATCTTTCCTAAACTACCAATAATAACTTTAAATTTTTGATCAACCATGCTAGAGCAAAGATTGAATTATCCTTCTGTTCTCTCTACA GAAATGATATAAAAACTATAGTCATAAGAAGAGACAATCAAAAATAATCAGCCATAAAATATTAAAAAGGTATTATAAAGGTATTTAAAA TAATAATAATAAAGTGTTATTTTCCTGGGATTCATGATATTTGATATATTCGTAAGCTTTTGTTAAGTTTGTAATTTGTTGCAATTTCTT >72889_72889_2_RBM39-WFDC13_RBM39_chr20_34300941_ENST00000361162_WFDC13_chr20_44333083_ENST00000305479_length(amino acids)=455AA_BP=382 MADDIDIEAMLEAPYKKDENKLSSANGHEERSKKRKKSKSRSRSHERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRR FRGRYRSPYSGPKFNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVR DVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIF EPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLM ARLAEGTGLQIPPAAQQALQMSGSLAFGAVAEYILEPPPCISAPENCTHLCTMQEDCEKGFQCCSSFCGIVCSSETFQKRNRIKHKGSEV -------------------------------------------------------------- >72889_72889_3_RBM39-WFDC13_RBM39_chr20_34300941_ENST00000407261_WFDC13_chr20_44333083_ENST00000305479_length(transcript)=2751nt_BP=1575nt GTGCTGGTGAATGTGAGTACAGGGAAGCAGCGGCCGCCATTTCAGGGAGCTTGTCGACGCTGTCGCAGGGGTGGATCCTGAGCTGCCGAA GCCGCCGTCCTGCTCTCCCGCGTGGGCTTCTCTAATTCCATTGTTTTTTTTAGATTCTCTCGGGCCTAGCCGTCCTTGGAACCCGATATT CGGGCTGGGCGGTTCCGCGGCCTGGGCCTAGGGGCTTAACAGTAGCAACAGAAGCGGCGGCGGCGGCAGCAGCAGCAGCAGCAGCAGCAA TCTCTTCCCGAACACGAGCACCACAGGCGCCCGAAGGCCGGAACAGGCGTTTAGAGAAAATGGCAGACGATATTGATATTGAAGCAATGC TTGAGGCTCCTTACAAGAAGGATGAGAACAAGTTGAGCAGTGCCAACGGCCATGAAGAACGTAGCAAAAAACAAACTTTCTGCCTCCTTG GAAAGCTCTACATCTCCTTGTGATTGGAGTGTGGGTTTCAAGATTCCAGAAGGAGGAAAAAAAGCAAGAGCAGAAGTCGTAGTCATGAAC GAAAGAGAAGCAAAAGTAAGGAACGGAAGCGAAGTAGAGACAGAGAAAGGAAAAAGAGCAAAAGCCGTGAAAGAAAGCGAAGTAGAAGCA AAGAGAGGCGACGGAGCCGCTCAAGAAGTCGAGATCGAAGATTTAGAGGCCGCTACAGAAGTCCTTACTCCGGACCAAAATTTAACAGTG CCATCCGAGGAAAGATTGGGTTGCCTCATAGCATCAAATTAAGCAGACGACGTTCCCGAAGCAAAAGTCCATTCAGAAAAGACAAGAGCC CTGTGAGAGAACCTATTGATAATTTAACTCCTGAGGAAAGAGATGCAAGGACAGTCTTCTGTATGCAGCTGGCGGCAAGAATTCGACCAA GGGATTTGGAAGAGTTTTTCTCTACAGTAGGAAAGGTTCGAGATGTGAGGATGATTTCTGACAGAAATTCAAGACGTTCCAAAGGAATTG CTTATGTGGAGTTCGTCGATGTTAGCTCAGTGCCTCTAGCAATAGGATTAACTGGCCAACGAGTTTTAGGCGTGCCAATCATAGTACAGG CATCACAGGCAGAAAAAAACAGAGCTGCAGCAATGGCAAACAATTTACAAAAGGGAAGTGCTGGACCTATGAGGCTTTATGTGGGCTCAT TACACTTCAACATAACTGAAGATATGCTTCGTGGGATCTTTGAGCCTTTTGGAAGAATTGAAAGTATCCAGCTGATGATGGACAGTGAAA CTGGTCGATCCAAGGGATATGGATTTATTACATTTTCTGACTCAGAATGTGCCAAAAAGGCTTTGGAACAACTTAATGGATTTGAACTAG CAGGAAGACCAATGAAAGTTGGTCATGTTACTGAACGTACTGATGCTTCGAGTGCTAGTTCATTTTTGGACAGTGATGAACTGGAAAGGA CTGGAATTGATTTGGGAACAACTGGTCGTCTTCAGTTAATGGCAAGACTTGCAGAGGGTACAGGTTTGCAGATTCCGCCAGCAGCACAGC AAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAGTATATCTTGGAACCTCCACCCTGCATATCAGCACCTGAAAACT GTACTCACCTGTGTACAATGCAGGAAGATTGCGAGAAAGGATTTCAGTGCTGTTCCTCCTTCTGTGGGATAGTCTGTTCATCAGAAACAT TTCAAAAGCGCAACAGAATCAAACACAAGGGCTCAGAAGTCATCATGCCTGCCAACTGAGGCATATTTCCTAGATCATTTTGCCTCTACG ATGTTTTTTCTTGGTCCACCTTTAGGAAGGTATTGAGAAGCAAGAAACTGGAGGCCCAATATCTAACCTGCAAATCGTTTTTGAGTTTGG CAATAAAGGCTAATCTACCATAAAACTCTTGAAGCTTAAGCTTTAGGTCAACACTTGCAAGAGCCCCTTCCAAAGCTCAGCACAGTTTCC TCCTGGGATGAGGAGAGGAATCAGAAACCCCACTTTGGCATAGAGACAAGCAGCACTGTTCCAGTCCAGGGATGCTGTGTGTGCCCTGGT GGTGGTCTTAAGGACCTACCACATCAACATCTGGACAACCCTCACTGATTACCTGCCCTTGGTTGCACTCATCAGGCTAATTGATCCCAT ATTTAACCTCAAGGAGAAATATCAACCAGACACTGCATGGCAACCTCCTTGGGGCCAGCCTTCAAGGCTTCATGGCCATATCATGAACCC AGGACAGGCACAGTGGGGGTGGTGAGGACCTGATAGAGTTGGATCAGTGACTAAGAGGCTGCAATAAGGTGCCATGAAATCAAAATCAAA GGGCTAGAACTCTCCAAGGTCTTGCCCCCGGCATGTAGCACCACCTGAGCCAGAAACTGCAGAGGACATGACAGTGTGGCATTACTGATA AGTTATGGAAATGGAAATAATCTTTCCTAAACTACCAATAATAACTTTAAATTTTTGATCAACCATGCTAGAGCAAAGATTGAATTATCC TTCTGTTCTCTCTACAGAAATGATATAAAAACTATAGTCATAAGAAGAGACAATCAAAAATAATCAGCCATAAAATATTAAAAAGGTATT ATAAAGGTATTTAAAATAATAATAATAAAGTGTTATTTTCCTGGGATTCATGATATTTGATATATTCGTAAGCTTTTGTTAAGTTTGTAA >72889_72889_3_RBM39-WFDC13_RBM39_chr20_34300941_ENST00000407261_WFDC13_chr20_44333083_ENST00000305479_length(amino acids)=431AA_BP=358 MECGFQDSRRRKKSKSRSRSHERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGPKFNSAIRGKIGL PHSIKLSRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDV SSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYG FITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGS -------------------------------------------------------------- >72889_72889_4_RBM39-WFDC13_RBM39_chr20_34300941_ENST00000528062_WFDC13_chr20_44333083_ENST00000305479_length(transcript)=2595nt_BP=1419nt ACAGGGAAGCAGCGGCCGCCATTTCAGGGAGCTTGTCGACGCTGTCGCAGGGGTGGATCCTGAGCTGCCGAAGCCGCCGTCCTGCTCTCC CGCGTGGGCTTCTCTAATTCCATTGTTTTTTTTAGATTCTCTCGGGCCTAGCCGTCCTTGGAACCCGATATTCGGGCTGGGCGGTTCCGC GGCCTGGGCCTAGGGGCTTAACAGTAGCAACAGAAGCGGCGGCGGCGGCAGCAGCAGCAGCAGCAGCAGCAATCTCTTCCCGAACACGAG CACCACAGGCGCCCGAAGGCCGGAACAGGCGTTTAGAGAAAATGGCAGACGATATTGATATTGAAGCAATGCTTGAGGCTCCTTACAAGA AGGATGAGAACAAGTTGAGCAGTGCCAACGGCCATGAAGAACGTAGCAAAAAGAGGAAAAAAAGCAAGAGCAGAAGTCGTAGTCATGAAC GAAAGAGAAGCAAAAGTAAGGAACGGAAGCGAAGTAGAGACAGAGAAAGGAAAAAGAGCAAAAGCCGTGAAAGAAAGCGAAGTAGAAGCA AAGAGAGGCGACGGAGCCGCTCAAGAAGTCGAGATCGAAGATTTAGAGGCCGCTACAGAAGTCCTTACAGACGACGTTCCCGAAGCAAAA GTCCATTCAGAAAAGACAAGAGCCCTGTGAGAGAACCTATTGATAATTTAACTCCTGAGGAAAGAGATGCAAGGACAGTCTTCTGTATGC AGCTGGCGGCAAGAATTCGACCAAGGGATTTGGAAGAGTTTTTCTCTACAGTAGGAAAGGTTCGAGATGTGAGGATGATTTCTGACAGAA ATTCAAGACGTTCCAAAGGAATTGCTTATGTGGAGTTCGTCGATGTTAGCTCAGTGCCTCTAGCAATAGGATTAACTGGCCAACGAGTTT TAGGCGTGCCAATCATAGTACAGGCATCACAGGCAGAAAAAAACAGAGCTGCAGCAATGGCAAACAATTTACAAAAGGGAAGTGCTGGAC CTATGAGGCTTTATGTGGGCTCATTACACTTCAACATAACTGAAGATATGCTTCGTGGGATCTTTGAGCCTTTTGGAAGAATTGAAAGTA TCCAGCTGATGATGGACAGTGAAACTGGTCGATCCAAGGGATATGGATTTATTACATTTTCTGACTCAGAATGTGCCAAAAAGGCTTTGG AACAACTTAATGGATTTGAACTAGCAGGAAGACCAATGAAAGTTGGTCATGTTACTGAACGTACTGATGCTTCGAGTGCTAGTTCATTTT TGGACAGTGATGAACTGGAAAGGACTGGAATTGATTTGGGAACAACTGGTCGTCTTCAGTTAATGGCAAGACTTGCAGAGGGTACAGGTT TGCAGATTCCGCCAGCAGCACAGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAGTATATCTTGGAACCTCCAC CCTGCATATCAGCACCTGAAAACTGTACTCACCTGTGTACAATGCAGGAAGATTGCGAGAAAGGATTTCAGTGCTGTTCCTCCTTCTGTG GGATAGTCTGTTCATCAGAAACATTTCAAAAGCGCAACAGAATCAAACACAAGGGCTCAGAAGTCATCATGCCTGCCAACTGAGGCATAT TTCCTAGATCATTTTGCCTCTACGATGTTTTTTCTTGGTCCACCTTTAGGAAGGTATTGAGAAGCAAGAAACTGGAGGCCCAATATCTAA CCTGCAAATCGTTTTTGAGTTTGGCAATAAAGGCTAATCTACCATAAAACTCTTGAAGCTTAAGCTTTAGGTCAACACTTGCAAGAGCCC CTTCCAAAGCTCAGCACAGTTTCCTCCTGGGATGAGGAGAGGAATCAGAAACCCCACTTTGGCATAGAGACAAGCAGCACTGTTCCAGTC CAGGGATGCTGTGTGTGCCCTGGTGGTGGTCTTAAGGACCTACCACATCAACATCTGGACAACCCTCACTGATTACCTGCCCTTGGTTGC ACTCATCAGGCTAATTGATCCCATATTTAACCTCAAGGAGAAATATCAACCAGACACTGCATGGCAACCTCCTTGGGGCCAGCCTTCAAG GCTTCATGGCCATATCATGAACCCAGGACAGGCACAGTGGGGGTGGTGAGGACCTGATAGAGTTGGATCAGTGACTAAGAGGCTGCAATA AGGTGCCATGAAATCAAAATCAAAGGGCTAGAACTCTCCAAGGTCTTGCCCCCGGCATGTAGCACCACCTGAGCCAGAAACTGCAGAGGA CATGACAGTGTGGCATTACTGATAAGTTATGGAAATGGAAATAATCTTTCCTAAACTACCAATAATAACTTTAAATTTTTGATCAACCAT GCTAGAGCAAAGATTGAATTATCCTTCTGTTCTCTCTACAGAAATGATATAAAAACTATAGTCATAAGAAGAGACAATCAAAAATAATCA GCCATAAAATATTAAAAAGGTATTATAAAGGTATTTAAAATAATAATAATAAAGTGTTATTTTCCTGGGATTCATGATATTTGATATATT >72889_72889_4_RBM39-WFDC13_RBM39_chr20_34300941_ENST00000528062_WFDC13_chr20_44333083_ENST00000305479_length(amino acids)=433AA_BP=360 MADDIDIEAMLEAPYKKDENKLSSANGHEERSKKRKKSKSRSRSHERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRR FRGRYRSPYRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFV DVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKG YGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RBM39-WFDC13 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000253363 | - | 12 | 17 | 355_406 | 391.3333333333333 | 531.0 | ESR1 and ESR2 |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000361162 | - | 12 | 17 | 355_406 | 391.3333333333333 | 525.0 | ESR1 and ESR2 |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000528062 | - | 11 | 16 | 355_406 | 369.3333333333333 | 509.0 | ESR1 and ESR2 |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000253363 | - | 12 | 17 | 291_406 | 391.3333333333333 | 531.0 | JUN |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000361162 | - | 12 | 17 | 291_406 | 391.3333333333333 | 525.0 | JUN |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000528062 | - | 11 | 16 | 291_406 | 369.3333333333333 | 509.0 | JUN |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000253363 | - | 12 | 17 | 406_530 | 391.3333333333333 | 531.0 | NCOA6 |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000361162 | - | 12 | 17 | 406_530 | 391.3333333333333 | 525.0 | NCOA6 |
| Hgene | RBM39 | chr20:34300941 | chr20:44333083 | ENST00000528062 | - | 11 | 16 | 406_530 | 369.3333333333333 | 509.0 | NCOA6 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RBM39-WFDC13 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RBM39-WFDC13 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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