FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:RBM4B-RBM4 (FusionGDB2 ID:72947)

Fusion Gene Summary for RBM4B-RBM4

check button Fusion gene summary
Fusion gene informationFusion gene name: RBM4B-RBM4
Fusion gene ID: 72947
HgeneTgene
Gene symbol

RBM4B

RBM4

Gene ID

83759

5936

Gene nameRNA binding motif protein 4BRNA binding motif protein 4
SynonymsRBM30|RBM4L|ZCCHC15|ZCCHC21B|ZCRB3BLARK|RBM4A|ZCCHC21|ZCRB3A
Cytomap

11q13.2

11q13.2

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein 4BRNA-binding motif protein 30zinc finger CCHC-type and RNA binding motif 3BRNA-binding protein 4RNA-binding motif protein 4alark homologtranscriptional coactivator CoAZzinc finger CCHC-type and RNA binding motif 3A
Modification date2020032720200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000310046, ENST00000524637, 
ENST00000525754, ENST00000531969, 
ENST00000529195, ENST00000531036, 
ENST00000310092, ENST00000396053, 
ENST00000398692, ENST00000408993, 
ENST00000409406, ENST00000483858, 
ENST00000503028, ENST00000506523, 
ENST00000530235, ENST00000532968, 
ENST00000578778, ENST00000514361, 
ENST00000515838, 
Fusion gene scores* DoF score6 X 5 X 3=907 X 10 X 4=280
# samples 611
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/280*10)=-1.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBM4B [Title/Abstract] AND RBM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRBM4B(66444138)-RBM4(66407170), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRBM4

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

12628928|16260624|16777844|16934801|21518792

TgeneRBM4

GO:0002190

cap-independent translational initiation

17284590

TgeneRBM4

GO:0002192

IRES-dependent translational initiation of linear mRNA

17284590

TgeneRBM4

GO:0017148

negative regulation of translation

17284590

TgeneRBM4

GO:0032055

negative regulation of translation in response to stress

17284590

TgeneRBM4

GO:0035278

miRNA mediated inhibition of translation

19801630

TgeneRBM4

GO:0045947

negative regulation of translational initiation

19801630

TgeneRBM4

GO:0046685

response to arsenic-containing substance

17284590

TgeneRBM4

GO:0046822

regulation of nucleocytoplasmic transport

12628928|17284590

TgeneRBM4

GO:0051149

positive regulation of muscle cell differentiation

21518792


check buttonFusion gene breakpoints across RBM4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RBM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI860431RBM4Bchr11

66444138

-RBM4chr11

66407170

+


Top

Fusion Gene ORF analysis for RBM4B-RBM4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000310046ENST00000310092RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000310046ENST00000396053RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000310046ENST00000398692RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000310046ENST00000408993RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000310046ENST00000409406RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000310046ENST00000483858RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000310046ENST00000503028RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000310046ENST00000506523RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000310046ENST00000530235RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000310046ENST00000532968RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000310046ENST00000578778RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000524637ENST00000310092RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000524637ENST00000396053RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000524637ENST00000398692RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000524637ENST00000408993RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000524637ENST00000409406RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000524637ENST00000483858RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000524637ENST00000503028RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000524637ENST00000506523RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000524637ENST00000530235RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000524637ENST00000532968RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000524637ENST00000578778RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000525754ENST00000310092RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000525754ENST00000396053RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000525754ENST00000398692RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000525754ENST00000408993RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000525754ENST00000409406RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000525754ENST00000483858RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000525754ENST00000503028RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000525754ENST00000506523RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000525754ENST00000530235RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000525754ENST00000532968RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000525754ENST00000578778RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000531969ENST00000310092RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000531969ENST00000396053RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000531969ENST00000398692RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000531969ENST00000408993RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000531969ENST00000409406RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000531969ENST00000483858RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000531969ENST00000503028RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000531969ENST00000506523RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000531969ENST00000530235RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000531969ENST00000532968RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-5UTRENST00000531969ENST00000578778RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-intronENST00000310046ENST00000514361RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-intronENST00000310046ENST00000515838RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-intronENST00000524637ENST00000514361RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-intronENST00000524637ENST00000515838RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-intronENST00000525754ENST00000514361RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-intronENST00000525754ENST00000515838RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-intronENST00000531969ENST00000514361RBM4Bchr11

66444138

-RBM4chr11

66407170

+
5CDS-intronENST00000531969ENST00000515838RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000529195ENST00000310092RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000529195ENST00000396053RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000529195ENST00000398692RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000529195ENST00000408993RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000529195ENST00000409406RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000529195ENST00000483858RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000529195ENST00000503028RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000529195ENST00000506523RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000529195ENST00000530235RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000529195ENST00000532968RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000529195ENST00000578778RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000531036ENST00000310092RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000531036ENST00000396053RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000531036ENST00000398692RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000531036ENST00000408993RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000531036ENST00000409406RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000531036ENST00000483858RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000531036ENST00000503028RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000531036ENST00000506523RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000531036ENST00000530235RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000531036ENST00000532968RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-5UTRENST00000531036ENST00000578778RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-intronENST00000529195ENST00000514361RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-intronENST00000529195ENST00000515838RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-intronENST00000531036ENST00000514361RBM4Bchr11

66444138

-RBM4chr11

66407170

+
intron-intronENST00000531036ENST00000515838RBM4Bchr11

66444138

-RBM4chr11

66407170

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for RBM4B-RBM4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RBM4Bchr1166444138-RBM4chr1166407170+1.88E-070.99999976
RBM4Bchr1166444138-RBM4chr1166407170+1.88E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for RBM4B-RBM4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:66444138/:66407170)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for RBM4B-RBM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for RBM4B-RBM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for RBM4B-RBM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for RBM4B-RBM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource