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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RBM5-SLC15A2 (FusionGDB2 ID:72962)

Fusion Gene Summary for RBM5-SLC15A2

check button Fusion gene summary
Fusion gene informationFusion gene name: RBM5-SLC15A2
Fusion gene ID: 72962
HgeneTgene
Gene symbol

RBM5

SLC15A2

Gene ID

10181

6565

Gene nameRNA binding motif protein 5solute carrier family 15 member 2
SynonymsG15|H37|LUCA-15|LUCA15|RMB5PEPT2
Cytomap

3p21.31

3q13.33

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein 5putative tumor suppressor LUCA15renal carcinoma antigen NY-REN-9solute carrier family 15 member 2kidney H(+)/peptide cotransporteroligopeptide transporter, kidney isoformpeptide transporter 2solute carrier family 15 (H+/peptide transporter), member 2solute carrier family 15 (oligopeptide transporter), member 2
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000347869, ENST00000469838, 
ENST00000441812, 
ENST00000465060, 
ENST00000295605, ENST00000489711, 
Fusion gene scores* DoF score7 X 6 X 5=2104 X 3 X 2=24
# samples 83
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RBM5 [Title/Abstract] AND SLC15A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRBM5(50131308)-SLC15A2(121658196), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRBM5

GO:0000245

spliceosomal complex assembly

18951082

HgeneRBM5

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

18840686|18951082

HgeneRBM5

GO:0043065

positive regulation of apoptotic process

18840686


check buttonFusion gene breakpoints across RBM5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC15A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CG-5721-11ARBM5chr3

50131308

+SLC15A2chr3

121658196

+


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Fusion Gene ORF analysis for RBM5-SLC15A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000347869ENST00000465060RBM5chr3

50131308

+SLC15A2chr3

121658196

+
5CDS-intronENST00000469838ENST00000465060RBM5chr3

50131308

+SLC15A2chr3

121658196

+
In-frameENST00000347869ENST00000295605RBM5chr3

50131308

+SLC15A2chr3

121658196

+
In-frameENST00000347869ENST00000489711RBM5chr3

50131308

+SLC15A2chr3

121658196

+
In-frameENST00000469838ENST00000295605RBM5chr3

50131308

+SLC15A2chr3

121658196

+
In-frameENST00000469838ENST00000489711RBM5chr3

50131308

+SLC15A2chr3

121658196

+
intron-3CDSENST00000441812ENST00000295605RBM5chr3

50131308

+SLC15A2chr3

121658196

+
intron-3CDSENST00000441812ENST00000489711RBM5chr3

50131308

+SLC15A2chr3

121658196

+
intron-intronENST00000441812ENST00000465060RBM5chr3

50131308

+SLC15A2chr3

121658196

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000347869RBM5chr350131308+ENST00000489711SLC15A2chr3121658196+4038514175942255
ENST00000347869RBM5chr350131308+ENST00000295605SLC15A2chr3121658196+1188514175942255
ENST00000469838RBM5chr350131308+ENST00000489711SLC15A2chr3121658196+4027503164931255
ENST00000469838RBM5chr350131308+ENST00000295605SLC15A2chr3121658196+1177503164931255

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000347869ENST00000489711RBM5chr350131308+SLC15A2chr3121658196+0.0003293110.99967074
ENST00000347869ENST00000295605RBM5chr350131308+SLC15A2chr3121658196+0.0013675780.9986324
ENST00000469838ENST00000489711RBM5chr350131308+SLC15A2chr3121658196+0.000325490.99967456
ENST00000469838ENST00000295605RBM5chr350131308+SLC15A2chr3121658196+0.0013423020.9986577

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Fusion Genomic Features for RBM5-SLC15A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RBM5chr350131308+SLC15A2chr3121658195+1.31E-050.9999869
RBM5chr350131308+SLC15A2chr3121658195+1.31E-050.9999869

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RBM5-SLC15A2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:50131308/chr3:121658196)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721633_643556699.0Topological domainCytoplasmic
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721665_674556699.0Topological domainExtracellular
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721696_729556699.0Topological domainCytoplasmic
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822633_643587730.0Topological domainCytoplasmic
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822665_674587730.0Topological domainExtracellular
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822696_729587730.0Topological domainCytoplasmic
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721612_632556699.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721644_664556699.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721675_695556699.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822612_632587730.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822644_664587730.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822675_695587730.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRBM5chr3:50131308chr3:121658196ENST00000347869+425231_315113816.0DomainRRM 2
HgeneRBM5chr3:50131308chr3:121658196ENST00000347869+425743_789113816.0DomainG-patch
HgeneRBM5chr3:50131308chr3:121658196ENST00000347869+42598_178113816.0DomainRRM 1
HgeneRBM5chr3:50131308chr3:121658196ENST00000469838+45231_315113144.0DomainRRM 2
HgeneRBM5chr3:50131308chr3:121658196ENST00000469838+45743_789113144.0DomainG-patch
HgeneRBM5chr3:50131308chr3:121658196ENST00000469838+4598_178113144.0DomainRRM 1
HgeneRBM5chr3:50131308chr3:121658196ENST00000347869+425181_210113816.0Zinc fingerRanBP2-type
HgeneRBM5chr3:50131308chr3:121658196ENST00000347869+425647_677113816.0Zinc fingerC2H2-type%3B atypical
HgeneRBM5chr3:50131308chr3:121658196ENST00000469838+45181_210113144.0Zinc fingerRanBP2-type
HgeneRBM5chr3:50131308chr3:121658196ENST00000469838+45647_677113144.0Zinc fingerC2H2-type%3B atypical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721402_611556699.0RegionExtracellular domain (ECD)
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822402_611587730.0RegionExtracellular domain (ECD)
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721105_113556699.0Topological domainCytoplasmic
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721135_139556699.0Topological domainExtracellular
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721161_183556699.0Topological domainCytoplasmic
TgeneSLC15A2chr3:50131308chr3:121658196ENST0000029560517211_57556699.0Topological domainCytoplasmic
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721205_217556699.0Topological domainExtracellular
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721239_295556699.0Topological domainCytoplasmic
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721317_343556699.0Topological domainExtracellular
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721365_380556699.0Topological domainCytoplasmic
TgeneSLC15A2chr3:50131308chr3:121658196ENST00000295605172179_83556699.0Topological domainExtracellular
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822105_113587730.0Topological domainCytoplasmic
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822135_139587730.0Topological domainExtracellular
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822161_183587730.0Topological domainCytoplasmic
TgeneSLC15A2chr3:50131308chr3:121658196ENST0000048971118221_57587730.0Topological domainCytoplasmic
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822205_217587730.0Topological domainExtracellular
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822239_295587730.0Topological domainCytoplasmic
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822317_343587730.0Topological domainExtracellular
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822365_380587730.0Topological domainCytoplasmic
TgeneSLC15A2chr3:50131308chr3:121658196ENST00000489711182279_83587730.0Topological domainExtracellular
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721114_134556699.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721140_160556699.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721184_204556699.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721218_238556699.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721296_316556699.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721344_364556699.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000002956051721381_401556699.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST00000295605172158_78556699.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST00000295605172184_104556699.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822114_134587730.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822140_160587730.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822184_204587730.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822218_238587730.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822296_316587730.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822344_364587730.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST000004897111822381_401587730.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST00000489711182258_78587730.0TransmembraneHelical
TgeneSLC15A2chr3:50131308chr3:121658196ENST00000489711182284_104587730.0TransmembraneHelical


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Fusion Gene Sequence for RBM5-SLC15A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72962_72962_1_RBM5-SLC15A2_RBM5_chr3_50131308_ENST00000347869_SLC15A2_chr3_121658196_ENST00000295605_length(transcript)=1188nt_BP=514nt
AAGCGTGAGGTACTGTGGGTAGGAGACGGCCGTCGGCGGAGGCGCCATTTTGTGTAGCCGCCGAACCTTGTTGGAGGTTCTGGGGCGCAG
AACCGCTACTGCTGCTTCGGTCTCTCCTTGGGAAAAAATAAAATTTGAACCTTTTGGAGCTGTGTGCTAAATCTTCAGTGGGACAATGGG
TTCAGACAAAAGAGTGAGTAGAACAGAGCGTAGTGGAAGATACGGTTCCATCATAGACAGGGATGACCGTGATGAGCGTGAATCCCGAAG
CAGGCGGAGGGACTCAGATTACAAAAGATCTAGTGATGATCGGAGGGGTGATAGATATGATGACTACCGAGACTATGACAGTCCAGAGAG
AGAGCGTGAAAGAAGGAACAGTGACCGATCCGAAGATGGCTACCATTCAGATGGTGACTATGGTGAGCACGACTATAGGCATGACATCAG
TGACGAGAGGGAGAGCAAGACCATCATGCTGCGCGGCCTTCCCATCACCATCACAGAGAGCGATAACACCAATCAGGGTCTTCAGGCCTG
GAAGATTGAAGACATTCCAGCCAACAAAATGTCCATTGCGTGGCAGCTACCACAATATGCCCTGGTTACAGCTGGGGAGGTCATGTTCTC
TGTCACAGGTCTTGAGTTTTCTTATTCTCAGGCTCCCTCTAGCATGAAATCTGTGCTCCAGGCAGCTTGGCTATTGACAATTGCAGTTGG
GAATATCATCGTGCTTGTTGTGGCACAGTTCAGTGGCCTGGTACAGTGGGCCGAATTCATTTTGTTTTCCTGCCTCCTGCTGGTGATCTG
CCTGATCTTCTCCATCATGGGCTACTACTATGTTCCTGTAAAGACAGAGGATATGCGGGGTCCAGCAGATAAGCACATTCCTCACATCCA
GGGGAACATGATCAAACTAGAGACCAAGAAGACAAAACTCTGATGACTCCCTAGATTCTGTCCTGACCCCAATTCCTGGCCCTGTCTTGA
AGCATTTTTTTTCTTCTACTGGATTAGACAAGAGAGATAGCAGCATATCAGAGCTGATCTCCTCCACCTTTCTCCAATGACAGAAGTTCC
AGGACTGGTTTTCCAGTACATCTTTAAACAAGGCCCCAGAGACTCTATGTCTGCCCGTCCATCAGTGAACTCATTAAAACTTGTGCAGTG

>72962_72962_1_RBM5-SLC15A2_RBM5_chr3_50131308_ENST00000347869_SLC15A2_chr3_121658196_ENST00000295605_length(amino acids)=255AA_BP=113
MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSDDRRGDRYDDYRDYDSPERERERRNSDRSEDGYHSDGDYGEHDYRHD
ISDERESKTIMLRGLPITITESDNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIA

--------------------------------------------------------------
>72962_72962_2_RBM5-SLC15A2_RBM5_chr3_50131308_ENST00000347869_SLC15A2_chr3_121658196_ENST00000489711_length(transcript)=4038nt_BP=514nt
AAGCGTGAGGTACTGTGGGTAGGAGACGGCCGTCGGCGGAGGCGCCATTTTGTGTAGCCGCCGAACCTTGTTGGAGGTTCTGGGGCGCAG
AACCGCTACTGCTGCTTCGGTCTCTCCTTGGGAAAAAATAAAATTTGAACCTTTTGGAGCTGTGTGCTAAATCTTCAGTGGGACAATGGG
TTCAGACAAAAGAGTGAGTAGAACAGAGCGTAGTGGAAGATACGGTTCCATCATAGACAGGGATGACCGTGATGAGCGTGAATCCCGAAG
CAGGCGGAGGGACTCAGATTACAAAAGATCTAGTGATGATCGGAGGGGTGATAGATATGATGACTACCGAGACTATGACAGTCCAGAGAG
AGAGCGTGAAAGAAGGAACAGTGACCGATCCGAAGATGGCTACCATTCAGATGGTGACTATGGTGAGCACGACTATAGGCATGACATCAG
TGACGAGAGGGAGAGCAAGACCATCATGCTGCGCGGCCTTCCCATCACCATCACAGAGAGCGATAACACCAATCAGGGTCTTCAGGCCTG
GAAGATTGAAGACATTCCAGCCAACAAAATGTCCATTGCGTGGCAGCTACCACAATATGCCCTGGTTACAGCTGGGGAGGTCATGTTCTC
TGTCACAGGTCTTGAGTTTTCTTATTCTCAGGCTCCCTCTAGCATGAAATCTGTGCTCCAGGCAGCTTGGCTATTGACAATTGCAGTTGG
GAATATCATCGTGCTTGTTGTGGCACAGTTCAGTGGCCTGGTACAGTGGGCCGAATTCATTTTGTTTTCCTGCCTCCTGCTGGTGATCTG
CCTGATCTTCTCCATCATGGGCTACTACTATGTTCCTGTAAAGACAGAGGATATGCGGGGTCCAGCAGATAAGCACATTCCTCACATCCA
GGGGAACATGATCAAACTAGAGACCAAGAAGACAAAACTCTGATGACTCCCTAGATTCTGTCCTGACCCCAATTCCTGGCCCTGTCTTGA
AGCATTTTTTTTCTTCTACTGGATTAGACAAGAGAGATAGCAGCATATCAGAGCTGATCTCCTCCACCTTTCTCCAATGACAGAAGTTCC
AGGACTGGTTTTCCAGTACATCTTTAAACAAGGCCCCAGAGACTCTATGTCTGCCCGTCCATCAGTGAACTCATTAAAACTTGTGCAGTG
TTGCTGGAGCTGGCCTGGTGTCTCCAAATGACCATGAAAATACACACGTATAATGGAGATCATTCTCTGTGGGTATGCAAAGTTATGGGA
ATTCCTTTATAGGTAACTGCCATTTAGGACTGATGGCCCTAATTTTTGAGGTGCTGATTTAGAGGCAAAATTGCAGAATAACAAAGAAAT
GGTATTTCAAGTTTTTTTTTTTATAAGCAATGTAATTATGCTATTCACAGGGGCCTCAAGAATTGGTATGTATGATGTGATCTGGTCCAG
CCAGGGCCTGGCTTGTCAGCTCTCTAGGTTTGATATGACTTTAGTAAATTTGTCAATATAGATGGTAGGAAGCAGAATGCCATTTTATTA
AAACACAGGAGAAGTTATATCTCTCTGATTATGATAGTATTTTATTTACTTATCCAAACCCTCCTTTCTCAGTATGGATAGATCATGGAA
ACCAGATTAGAGATAGTAAGCATTAGTAAACATTGTTCTGGAGAACAGGAACAGGTGTAAGTTGTAGAAATCCTGAAGAGCCAGTCATTC
TTTTACAGAGTACATTCTTCTTAGCCTCTATGGCGCTGGTCTATGCCCTTCAGTGAACAGTTGTATAAACAATAATTATAATTTGCAACC
TTGTCTTGTCAACCTTGCTGATCCAGCTTTTTCTTATTATTACACCTTGTCTTGCTTATTGCAGCAAATATTCAATAACAACAATGTTTC
TATAAGTCCAACTTCCTTTATTAATGTTTCCATTTAGCCTCAAAAATATCAAAGTAGTTCCTTTTTGATGTTGTTTTCCTGATTTACTTT
TCCCATAAGTTTTAAATACCATTTCTGCCTTGAAGCCTAGAAATTTTCTTTTTATTCAAAAAAAGTTACATTAATGCTCTAGGTTTGAGG
TTCTAAAATGGAAATGTCAATAGAGGAGCATGGTCCTATGTGAGGTTCCTATCAAAATTTGTGGGAGTAGGGATGGTAGAGCATGAGGGT
TTTGTTTGTGTATGTGTATGGTCATGAAAAAAAATTGAGAAACATTACCTCATACACAATGAATGAATCAGAGGACAGACACGGGAATGG
CACGACTGTGCAGTGTGTTACTAGGAAAAAAGTTCAGAATCACTGTTCTAGAGAGCTTCATTTCCATTGGTTTTAAAACATTATTCTCAT
GTAGAACAGTGTTGGGTCTCATACTGTTAATGTTAATACGTAACAATGTTCATGTTAACAGGCACCTGTTAATATTAACAGATAATGTTA
CTGTTAACAGGTAAGAGAAATTGCTCTAAGTGCCCAAACTTTATATACTTCAGTTTTAATGACAAGCATTTCAGAAATATAAGAGCGGCA
GCCAGACCAACCAGTTTTTCCAGATATCTTGATGTGAACCTGACCCTACTCCTTTAGAAGACAGCCTGTTCATTTTTAAATAGCTTTAAC
CCAAACTGTTCTATGACCATTGTTTCAAGAGACATTAACACAGTTCTGTAAATAGAAGTGTCTATGGACAAATAAGTTTGGGAAATGTGG
CATACTGTATCCTTTTCTTAACATTTGCATATTAAAGACTCTGAGATATCCTGCAGTAAAGACACAAGATACCTTGTTTAAATTAACATG
TACGCTGCAGAACATTGGTTTGGAAAAAACTGTTGAGCAGTTCTTCCTTGTAAGTGCTGAGCTTCCTCTCTGAAACCTCCTACCATTGTT
TTTTTTCCCCTGTAGCTAACAAGAATAAGTATAACAGCCGGCCAGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAG
ACAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCGTGTCTCTACTAAAAGTACAAAAATTAGCCAG
GTGTGATGGCAGGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAAGCAGAAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCAATGAGCC
GAGATCACGCCATCACACTCTAGCCTGGGGGACAAGAGTGAGACTTCATCTAAAAAAAAAAAGAAAAGAATATGTATACCCCCTTTTTCA
TGTGGCAGATGTTTAGCTATTTGGGGAGAACTTTCATGGCTCTTCCCTAATCATCAAGTATTCAAGGTAAAGATTCTCGGTTCCTGTAAT
GGTTCCTCACCAGGCATAATTTGTCCTTTTACCATCCTACTTTCTGTCTTCTGAAAAACATTCTTTATCTGAAATACAGCAATTAATATT
AAGATATCTTAATATGAAGTGCCTGGAGTCAAATATAACATTCCAAAGTAGTCTGACTGGAAGAACTAGCACCTGCCTTTCTTCAAACAA
TGCACTTCTGTTAATGCAGTGTAAGGTAACATGAGTTGTTTTTGGAAACTACATCATAATGTGGGCTTACATTCTAGCACTTATCACTTA
ATGACAGGGATACATTTGAGGAATGCATTGTTAGGCAATTTTGTCATTATGCAAACATCATAGAGTGTACTTACACAAACCTATGGTATA
GCCTACTACACATCTAAGTTATATGGTATAGACTGTTTCTCCAGCTATATGGTGTAGACTGTTTCTCCTAGGCTACAAACCTGCACAGCA
TGTTACTGTATTAAATGCTGTAGGCAATTGTAACACAATGGTATTTTTATACTTAAACATATCTAAACATAGAAACGGTACAAAAAACTT
TACACATTATATAGATGTATCAAATTATTCATATGTGCTCTGAAAATGTCTATATCTGTTATGTATCAATTTTTTAAAAAGTGAATGACA

>72962_72962_2_RBM5-SLC15A2_RBM5_chr3_50131308_ENST00000347869_SLC15A2_chr3_121658196_ENST00000489711_length(amino acids)=255AA_BP=113
MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSDDRRGDRYDDYRDYDSPERERERRNSDRSEDGYHSDGDYGEHDYRHD
ISDERESKTIMLRGLPITITESDNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIA

--------------------------------------------------------------
>72962_72962_3_RBM5-SLC15A2_RBM5_chr3_50131308_ENST00000469838_SLC15A2_chr3_121658196_ENST00000295605_length(transcript)=1177nt_BP=503nt
ACTGTGGGTAGGAGACGGCCGTCGGCGGAGGCGCCATTTTGTGTAGCCGCCGAACCTTGTTGGAGGTTCTGGGGCGCAGAACCGCTACTG
CTGCTTCGGTCTCTCCTTGGGAAAAAATAAAATTTGAACCTTTTGGAGCTGTGTGCTAAATCTTCAGTGGGACAATGGGTTCAGACAAAA
GAGTGAGTAGAACAGAGCGTAGTGGAAGATACGGTTCCATCATAGACAGGGATGACCGTGATGAGCGTGAATCCCGAAGCAGGCGGAGGG
ACTCAGATTACAAAAGATCTAGTGATGATCGGAGGGGTGATAGATATGATGACTACCGAGACTATGACAGTCCAGAGAGAGAGCGTGAAA
GAAGGAACAGTGACCGATCCGAAGATGGCTACCATTCAGATGGTGACTATGGTGAGCACGACTATAGGCATGACATCAGTGACGAGAGGG
AGAGCAAGACCATCATGCTGCGCGGCCTTCCCATCACCATCACAGAGAGCGATAACACCAATCAGGGTCTTCAGGCCTGGAAGATTGAAG
ACATTCCAGCCAACAAAATGTCCATTGCGTGGCAGCTACCACAATATGCCCTGGTTACAGCTGGGGAGGTCATGTTCTCTGTCACAGGTC
TTGAGTTTTCTTATTCTCAGGCTCCCTCTAGCATGAAATCTGTGCTCCAGGCAGCTTGGCTATTGACAATTGCAGTTGGGAATATCATCG
TGCTTGTTGTGGCACAGTTCAGTGGCCTGGTACAGTGGGCCGAATTCATTTTGTTTTCCTGCCTCCTGCTGGTGATCTGCCTGATCTTCT
CCATCATGGGCTACTACTATGTTCCTGTAAAGACAGAGGATATGCGGGGTCCAGCAGATAAGCACATTCCTCACATCCAGGGGAACATGA
TCAAACTAGAGACCAAGAAGACAAAACTCTGATGACTCCCTAGATTCTGTCCTGACCCCAATTCCTGGCCCTGTCTTGAAGCATTTTTTT
TCTTCTACTGGATTAGACAAGAGAGATAGCAGCATATCAGAGCTGATCTCCTCCACCTTTCTCCAATGACAGAAGTTCCAGGACTGGTTT
TCCAGTACATCTTTAAACAAGGCCCCAGAGACTCTATGTCTGCCCGTCCATCAGTGAACTCATTAAAACTTGTGCAGTGTTGCTGGAGCT

>72962_72962_3_RBM5-SLC15A2_RBM5_chr3_50131308_ENST00000469838_SLC15A2_chr3_121658196_ENST00000295605_length(amino acids)=255AA_BP=113
MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSDDRRGDRYDDYRDYDSPERERERRNSDRSEDGYHSDGDYGEHDYRHD
ISDERESKTIMLRGLPITITESDNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIA

--------------------------------------------------------------
>72962_72962_4_RBM5-SLC15A2_RBM5_chr3_50131308_ENST00000469838_SLC15A2_chr3_121658196_ENST00000489711_length(transcript)=4027nt_BP=503nt
ACTGTGGGTAGGAGACGGCCGTCGGCGGAGGCGCCATTTTGTGTAGCCGCCGAACCTTGTTGGAGGTTCTGGGGCGCAGAACCGCTACTG
CTGCTTCGGTCTCTCCTTGGGAAAAAATAAAATTTGAACCTTTTGGAGCTGTGTGCTAAATCTTCAGTGGGACAATGGGTTCAGACAAAA
GAGTGAGTAGAACAGAGCGTAGTGGAAGATACGGTTCCATCATAGACAGGGATGACCGTGATGAGCGTGAATCCCGAAGCAGGCGGAGGG
ACTCAGATTACAAAAGATCTAGTGATGATCGGAGGGGTGATAGATATGATGACTACCGAGACTATGACAGTCCAGAGAGAGAGCGTGAAA
GAAGGAACAGTGACCGATCCGAAGATGGCTACCATTCAGATGGTGACTATGGTGAGCACGACTATAGGCATGACATCAGTGACGAGAGGG
AGAGCAAGACCATCATGCTGCGCGGCCTTCCCATCACCATCACAGAGAGCGATAACACCAATCAGGGTCTTCAGGCCTGGAAGATTGAAG
ACATTCCAGCCAACAAAATGTCCATTGCGTGGCAGCTACCACAATATGCCCTGGTTACAGCTGGGGAGGTCATGTTCTCTGTCACAGGTC
TTGAGTTTTCTTATTCTCAGGCTCCCTCTAGCATGAAATCTGTGCTCCAGGCAGCTTGGCTATTGACAATTGCAGTTGGGAATATCATCG
TGCTTGTTGTGGCACAGTTCAGTGGCCTGGTACAGTGGGCCGAATTCATTTTGTTTTCCTGCCTCCTGCTGGTGATCTGCCTGATCTTCT
CCATCATGGGCTACTACTATGTTCCTGTAAAGACAGAGGATATGCGGGGTCCAGCAGATAAGCACATTCCTCACATCCAGGGGAACATGA
TCAAACTAGAGACCAAGAAGACAAAACTCTGATGACTCCCTAGATTCTGTCCTGACCCCAATTCCTGGCCCTGTCTTGAAGCATTTTTTT
TCTTCTACTGGATTAGACAAGAGAGATAGCAGCATATCAGAGCTGATCTCCTCCACCTTTCTCCAATGACAGAAGTTCCAGGACTGGTTT
TCCAGTACATCTTTAAACAAGGCCCCAGAGACTCTATGTCTGCCCGTCCATCAGTGAACTCATTAAAACTTGTGCAGTGTTGCTGGAGCT
GGCCTGGTGTCTCCAAATGACCATGAAAATACACACGTATAATGGAGATCATTCTCTGTGGGTATGCAAAGTTATGGGAATTCCTTTATA
GGTAACTGCCATTTAGGACTGATGGCCCTAATTTTTGAGGTGCTGATTTAGAGGCAAAATTGCAGAATAACAAAGAAATGGTATTTCAAG
TTTTTTTTTTTATAAGCAATGTAATTATGCTATTCACAGGGGCCTCAAGAATTGGTATGTATGATGTGATCTGGTCCAGCCAGGGCCTGG
CTTGTCAGCTCTCTAGGTTTGATATGACTTTAGTAAATTTGTCAATATAGATGGTAGGAAGCAGAATGCCATTTTATTAAAACACAGGAG
AAGTTATATCTCTCTGATTATGATAGTATTTTATTTACTTATCCAAACCCTCCTTTCTCAGTATGGATAGATCATGGAAACCAGATTAGA
GATAGTAAGCATTAGTAAACATTGTTCTGGAGAACAGGAACAGGTGTAAGTTGTAGAAATCCTGAAGAGCCAGTCATTCTTTTACAGAGT
ACATTCTTCTTAGCCTCTATGGCGCTGGTCTATGCCCTTCAGTGAACAGTTGTATAAACAATAATTATAATTTGCAACCTTGTCTTGTCA
ACCTTGCTGATCCAGCTTTTTCTTATTATTACACCTTGTCTTGCTTATTGCAGCAAATATTCAATAACAACAATGTTTCTATAAGTCCAA
CTTCCTTTATTAATGTTTCCATTTAGCCTCAAAAATATCAAAGTAGTTCCTTTTTGATGTTGTTTTCCTGATTTACTTTTCCCATAAGTT
TTAAATACCATTTCTGCCTTGAAGCCTAGAAATTTTCTTTTTATTCAAAAAAAGTTACATTAATGCTCTAGGTTTGAGGTTCTAAAATGG
AAATGTCAATAGAGGAGCATGGTCCTATGTGAGGTTCCTATCAAAATTTGTGGGAGTAGGGATGGTAGAGCATGAGGGTTTTGTTTGTGT
ATGTGTATGGTCATGAAAAAAAATTGAGAAACATTACCTCATACACAATGAATGAATCAGAGGACAGACACGGGAATGGCACGACTGTGC
AGTGTGTTACTAGGAAAAAAGTTCAGAATCACTGTTCTAGAGAGCTTCATTTCCATTGGTTTTAAAACATTATTCTCATGTAGAACAGTG
TTGGGTCTCATACTGTTAATGTTAATACGTAACAATGTTCATGTTAACAGGCACCTGTTAATATTAACAGATAATGTTACTGTTAACAGG
TAAGAGAAATTGCTCTAAGTGCCCAAACTTTATATACTTCAGTTTTAATGACAAGCATTTCAGAAATATAAGAGCGGCAGCCAGACCAAC
CAGTTTTTCCAGATATCTTGATGTGAACCTGACCCTACTCCTTTAGAAGACAGCCTGTTCATTTTTAAATAGCTTTAACCCAAACTGTTC
TATGACCATTGTTTCAAGAGACATTAACACAGTTCTGTAAATAGAAGTGTCTATGGACAAATAAGTTTGGGAAATGTGGCATACTGTATC
CTTTTCTTAACATTTGCATATTAAAGACTCTGAGATATCCTGCAGTAAAGACACAAGATACCTTGTTTAAATTAACATGTACGCTGCAGA
ACATTGGTTTGGAAAAAACTGTTGAGCAGTTCTTCCTTGTAAGTGCTGAGCTTCCTCTCTGAAACCTCCTACCATTGTTTTTTTTCCCCT
GTAGCTAACAAGAATAAGTATAACAGCCGGCCAGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGACAGGTGGATC
ACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCGTGTCTCTACTAAAAGTACAAAAATTAGCCAGGTGTGATGGCA
GGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAAGCAGAAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCAATGAGCCGAGATCACGCC
ATCACACTCTAGCCTGGGGGACAAGAGTGAGACTTCATCTAAAAAAAAAAAGAAAAGAATATGTATACCCCCTTTTTCATGTGGCAGATG
TTTAGCTATTTGGGGAGAACTTTCATGGCTCTTCCCTAATCATCAAGTATTCAAGGTAAAGATTCTCGGTTCCTGTAATGGTTCCTCACC
AGGCATAATTTGTCCTTTTACCATCCTACTTTCTGTCTTCTGAAAAACATTCTTTATCTGAAATACAGCAATTAATATTAAGATATCTTA
ATATGAAGTGCCTGGAGTCAAATATAACATTCCAAAGTAGTCTGACTGGAAGAACTAGCACCTGCCTTTCTTCAAACAATGCACTTCTGT
TAATGCAGTGTAAGGTAACATGAGTTGTTTTTGGAAACTACATCATAATGTGGGCTTACATTCTAGCACTTATCACTTAATGACAGGGAT
ACATTTGAGGAATGCATTGTTAGGCAATTTTGTCATTATGCAAACATCATAGAGTGTACTTACACAAACCTATGGTATAGCCTACTACAC
ATCTAAGTTATATGGTATAGACTGTTTCTCCAGCTATATGGTGTAGACTGTTTCTCCTAGGCTACAAACCTGCACAGCATGTTACTGTAT
TAAATGCTGTAGGCAATTGTAACACAATGGTATTTTTATACTTAAACATATCTAAACATAGAAACGGTACAAAAAACTTTACACATTATA
TAGATGTATCAAATTATTCATATGTGCTCTGAAAATGTCTATATCTGTTATGTATCAATTTTTTAAAAAGTGAATGACATAATTCATTTG

>72962_72962_4_RBM5-SLC15A2_RBM5_chr3_50131308_ENST00000469838_SLC15A2_chr3_121658196_ENST00000489711_length(amino acids)=255AA_BP=113
MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSDDRRGDRYDDYRDYDSPERERERRNSDRSEDGYHSDGDYGEHDYRHD
ISDERESKTIMLRGLPITITESDNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RBM5-SLC15A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RBM5-SLC15A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RBM5-SLC15A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource