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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RBMS1-ITGB6 (FusionGDB2 ID:73015)

Fusion Gene Summary for RBMS1-ITGB6

check button Fusion gene summary
Fusion gene informationFusion gene name: RBMS1-ITGB6
Fusion gene ID: 73015
HgeneTgene
Gene symbol

RBMS1

ITGB6

Gene ID

5937

3694

Gene nameRNA binding motif single stranded interacting protein 1integrin subunit beta 6
SynonymsC2orf12|HCC-4|MSSP|MSSP-1|MSSP-2|MSSP-3|SCR2|YC1AI1H
Cytomap

2q24.2

2q24.2

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding motif, single-stranded-interacting protein 1c-myc gene single strand binding protein 2cervical cancer oncogene 4single-stranded DNA-binding protein MSSP-1suppressor of CDC2 with RNA-binding motif 2suppressor of cdc 2 (cdc13) with RNA bindintegrin beta-6integrin, beta 6
Modification date2020032020200313
UniProtAcc.

P18564

Ensembl transtripts involved in fusion geneENST00000348849, ENST00000392753, 
ENST00000409075, ENST00000409289, 
ENST00000409972, ENST00000474820, 
ENST00000409872, ENST00000409967, 
ENST00000428609, ENST00000485635, 
ENST00000283249, 
Fusion gene scores* DoF score13 X 7 X 9=8198 X 6 X 8=384
# samples 1110
** MAII scorelog2(11/819*10)=-2.89635992811635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/384*10)=-1.94110631094643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBMS1 [Title/Abstract] AND ITGB6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITGB6(161051880)-RBMS1(161174738), # samples:4
RBMS1(161174680)-ITGB6(160994710), # samples:1
Anticipated loss of major functional domain due to fusion event.RBMS1-ITGB6 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneITGB6

GO:0033627

cell adhesion mediated by integrin

17158881

TgeneITGB6

GO:1901388

regulation of transforming growth factor beta activation

22278742


check buttonFusion gene breakpoints across RBMS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITGB6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-7822RBMS1chr2

161174680

-ITGB6chr2

160994710

-


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Fusion Gene ORF analysis for RBMS1-ITGB6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000348849ENST00000409872RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000348849ENST00000409967RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000348849ENST00000428609RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000348849ENST00000485635RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000392753ENST00000409872RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000392753ENST00000409967RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000392753ENST00000428609RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000392753ENST00000485635RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000409075ENST00000409872RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000409075ENST00000409967RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000409075ENST00000428609RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000409075ENST00000485635RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000409289ENST00000409872RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000409289ENST00000409967RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000409289ENST00000428609RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000409289ENST00000485635RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000409972ENST00000409872RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000409972ENST00000409967RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000409972ENST00000428609RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5CDS-intronENST00000409972ENST00000485635RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5UTR-3CDSENST00000474820ENST00000283249RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5UTR-intronENST00000474820ENST00000409872RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5UTR-intronENST00000474820ENST00000409967RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5UTR-intronENST00000474820ENST00000428609RBMS1chr2

161174680

-ITGB6chr2

160994710

-
5UTR-intronENST00000474820ENST00000485635RBMS1chr2

161174680

-ITGB6chr2

160994710

-
Frame-shiftENST00000348849ENST00000283249RBMS1chr2

161174680

-ITGB6chr2

160994710

-
Frame-shiftENST00000392753ENST00000283249RBMS1chr2

161174680

-ITGB6chr2

160994710

-
Frame-shiftENST00000409972ENST00000283249RBMS1chr2

161174680

-ITGB6chr2

160994710

-
In-frameENST00000409075ENST00000283249RBMS1chr2

161174680

-ITGB6chr2

160994710

-
In-frameENST00000409289ENST00000283249RBMS1chr2

161174680

-ITGB6chr2

160994710

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409075RBMS1chr2161174680-ENST00000283249ITGB6chr2160994710-36663363391595418
ENST00000409289RBMS1chr2161174680-ENST00000283249ITGB6chr2160994710-36062762791535418

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409075ENST00000283249RBMS1chr2161174680-ITGB6chr2160994710-0.0002591050.9997409
ENST00000409289ENST00000283249RBMS1chr2161174680-ITGB6chr2160994710-0.0002718980.99972814

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Fusion Genomic Features for RBMS1-ITGB6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RBMS1-ITGB6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:161051880/chr2:161174738)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ITGB6

P18564

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881). It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881). Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:17545607, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:28117447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260). {ECO:0000269|PubMed:24367260}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneITGB6chr2:161174680chr2:160994710ENST00000283249715456_619369789.0RegionNote=Cysteine-rich tandem repeats
TgeneITGB6chr2:161174680chr2:160994710ENST00000409872816456_619369789.0RegionNote=Cysteine-rich tandem repeats
TgeneITGB6chr2:161174680chr2:160994710ENST00000283249715456_501369789.0RepeatNote=I
TgeneITGB6chr2:161174680chr2:160994710ENST00000283249715502_543369789.0RepeatNote=II
TgeneITGB6chr2:161174680chr2:160994710ENST00000283249715544_582369789.0RepeatNote=III
TgeneITGB6chr2:161174680chr2:160994710ENST00000283249715583_619369789.0RepeatNote=IV
TgeneITGB6chr2:161174680chr2:160994710ENST00000409872816456_501369789.0RepeatNote=I
TgeneITGB6chr2:161174680chr2:160994710ENST00000409872816502_543369789.0RepeatNote=II
TgeneITGB6chr2:161174680chr2:160994710ENST00000409872816544_582369789.0RepeatNote=III
TgeneITGB6chr2:161174680chr2:160994710ENST00000409872816583_619369789.0RepeatNote=IV
TgeneITGB6chr2:161174680chr2:160994710ENST00000283249715731_788369789.0Topological domainCytoplasmic
TgeneITGB6chr2:161174680chr2:160994710ENST00000409872816731_788369789.0Topological domainCytoplasmic
TgeneITGB6chr2:161174680chr2:160994710ENST00000283249715710_730369789.0TransmembraneHelical
TgeneITGB6chr2:161174680chr2:160994710ENST00000409872816710_730369789.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRBMS1chr2:161174680chr2:160994710ENST00000348849-314141_2261031079.3333333333333DomainRRM 2
HgeneRBMS1chr2:161174680chr2:160994710ENST00000348849-31462_1351031079.3333333333333DomainRRM 1
TgeneITGB6chr2:161174680chr2:160994710ENST00000283249715131_371369789.0DomainNote=VWFA
TgeneITGB6chr2:161174680chr2:160994710ENST00000409872816131_371369789.0DomainNote=VWFA
TgeneITGB6chr2:161174680chr2:160994710ENST0000028324971522_709369789.0Topological domainExtracellular
TgeneITGB6chr2:161174680chr2:160994710ENST0000040987281622_709369789.0Topological domainExtracellular


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Fusion Gene Sequence for RBMS1-ITGB6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>73015_73015_1_RBMS1-ITGB6_RBMS1_chr2_161174680_ENST00000409075_ITGB6_chr2_160994710_ENST00000283249_length(transcript)=3666nt_BP=336nt
GGAAGGATTACACTGTTCCAGGTTTTAGGGAGAAAGGTTTACCAAACCGGTGGCCTTAAATGATTTTCGCTCCTTGATATTATCATCTTG
AAGGAAAGCTGCAGTCTCTGGTCCCAGCCCACCCCATGGCCCCTCCCAGTCCCAGCACCACCAGCAGTAATAACAACAGTAGCAGCAGTA
GCAACTCAGGATGGGATCAGCTCAGCAAAACGAACCTCTATATCCGAGGACTGCCTCCCCACACCACCGACCAGGACCTGGTGAAGCTCT
GTCAACCATATGGGAAAATAGTCTCCACAAAGGCAATTTTGGATAAGACAACGAACAAATGCAAAGGAACTGCGGTCTGAGGTGGAACTG
GAAGTATTAGGAGACACTGAAGGACTCAACTTGTCATTTACAGCCATCTGTAACAACGGTACCCTCTTCCAACACCAAAAGAAATGCTCT
CACATGAAAGTGGGAGACACAGCTTCCTTCAGCGTGACTGTGAATATCCCACACTGCGAGAGAAGAAGCAGGCACATTATCATAAAGCCT
GTGGGGCTGGGGGATGCCCTGGAATTACTTGTCAGCCCAGAATGCAACTGCGACTGTCAGAAAGAAGTGGAAGTGAACAGCTCCAAATGT
CACCACGGGAACGGCTCTTTCCAGTGTGGGGTGTGTGCCTGCCACCCTGGCCACATGGGGCCTCGCTGTGAGTGTGGCGAGGACATGCTG
AGCACAGATTCCTGCAAGGAGGCCCCAGATCATCCCTCCTGCAGCGGAAGGGGTGACTGCTACTGTGGGCAGTGTATCTGCCACTTGTCT
CCCTATGGAAACATTTATGGGCCTTATTGCCAGTGTGACAATTTCTCCTGCGTGAGACACAAAGGGCTGCTCTGCGGAGGTAACGGCGAC
TGTGACTGTGGTGAATGTGTGTGCAGGAGCGGCTGGACTGGCGAGTACTGCAACTGCACCACCAGCACGGACTCCTGCGTCTCTGAAGAT
GGAGTGCTCTGCAGCGGGCGCGGGGACTGTGTTTGTGGCAAGTGTGTTTGCACAAACCCTGGAGCCTCAGGACCAACCTGTGAACGATGT
CCTACCTGTGGTGACCCCTGTAACTCTAAACGGAGCTGCATTGAGTGCCACCTGTCAGCAGCTGGCCAAGCCCGAGAAGAATGTGTGGAC
AAGTGCAAACTAGCTGGTGCGACCATCAGTGAAGAAGAAGATTTCTCAAAGGATGGTTCTGTTTCCTGCTCTCTGCAAGGAGAAAATGAA
TGTCTTATTACATTCCTAATAACTACAGATAATGAGGGGAAAACCATCATTCACAGCATCAATGAAAAAGATTGTCCGAAGCCTCCAAAC
ATTCCCATGATCATGTTAGGGGTTTCCCTGGCTATTCTTCTCATCGGGGTTGTCCTACTGTGCATCTGGAAGCTACTGGTGTCATTTCAT
GATCGTAAAGAAGTTGCCAAATTTGAAGCAGAACGATCAAAAGCCAAGTGGCAAACGGGAACCAATCCACTCTACAGAGGATCCACAAGT
ACTTTTAAAAATGTAACTTATAAACACAGGGAAAAACAAAAGGTAGACCTTTCCACAGATTGCTAGAACTACTTTATGCATGAAAAAAGT
CTGTTTCACTGATATGAAATGTTAATGCACTATTTAATTTTTTTCTCTTTGTTGCTTCAAAATGAGGTTGGTTTAAGATAATAATAGGAC
ATCTGCAGATAAGTCATCCTCTACATGAAGGTGACAGACTGTTGGCAGTTTCAAAATAATCAAGAAGAGAAATATCCTTAGCAAAGAGAT
GACTTTGGGGATCATTTGAGGAATACTAACTCTGTTGCATTAATGCTTCAAAAAATCATCAAATGATTCATGGGGGCCTGATTTGCATTT
GAAAAATGTTTGAAATTAGAGTCTCATTTGTTTCAGGAATGCAGCTACCTGAGTTTTTTGTCTCGGCAAAGTCACAAAGCCCATATACTC
ACATTGTGTGTCTATACTTGCCAATTAATTCTAAACTTGTAGGAAATATGCCCTCTCTTAAAGGAGAATTTTTTTTAAATCTCTGAGAAA
TGAGATTCTGAGTTTATTTCAGCTAAAAGGTTGCAATTCTTCTGAAGATATCTCAAATATAAGGTTGAAAGTTAAGTGTTAATAATTTTT
GTGAATTTATACACACCTAAACGTTAAGTACACAAATATTTTATTTGTTTTACAAATAAGGAATAAGTAATTTATAAATTAAGAAGTTAC
CTATAAAAATAAAAAGATAACAACCCTATCATATAGCTTATTTTTAAATTACCTGAAAAACGATATTCTACACTGTTTCCTTTTTGACTC
TGAGTTTTCAAACTGTTACTTCTCCCATATTTCTCAATCCATTTCACTCAGTTGCACAGTCTTTTAAACCCTGTAATTGTCATACCAAAG
TTTCTTTTTAAAAAAAAATTACTTTAAATGCTTAGTTTATTCAAAGAGCGATCCAATAATATAAAAGGAACATGTGTTAAACACAATAAA
ATTTTAAATGGCTCTAAATCAAGCACATCAAGAGTATACAAGTCTTAAAGGCTTTTTAATACATACTCTTTTCCCATCTATGTAACCCAA
CTTGCACATTTCAGCTGCATGTGGTGAATATGCATCATATATTTACTTTAAGAGGTAAGATTTTACTTGCAAAATACATGTGCAAATTAG
GGATCCATCAGTTGATGGAAGAGATGGACTCTAGAATATTATTTCTTGTGGTTATTACTCCTTTACAAAGCACTTTCGTCTCACTTGATC
CTCATAAGGAAACTAAGGCTCAGAATGAGTAGAGCTGGGTTCAGAATCTAGCTCTTCTAACTCCAAGCCATCTCCTCTTTCCACTGCAGG
AAACTGCCTCTTTTGTCAGTGAAATAATAGAAAGATTGTGTTAGTTAAGTGATAACTGTCATTTGTTTGAAAATGTTCGAGACTGAACAA
ATAGCATTTAAACTGCTGGCATATAGATGAGATATTGTACTTTTGTGCAATGTTTATTACCTTTGATTAAATTGTAATGTGAAGCTTTTA
CTAGGTGAATAGTTCATTATGTAGTGGAGGCTTCGTGGTTGTCCATTGAATTGTCACAGCAAAATCTATAAGTTTCTTCAATTCTACAAG
ATAGATCCATATACCTTTGATCACTTGGAGACTCTTTTTTTGCTGGTTTCTAGATAACTCAGGTAAATCAGACCTTTACAGAGTACAGGG
CTAGGTGAAAGAATTACTGAAAAATCACCTTGAAAATCCGAAGGGCTGATATACCCTTTATGTTCCTGACTGATGCGCAGAACCTGGGGG
AAATCTACAGCAATATACAGGTTGCAATGCTGATAACACAACAGCAATCCTCTCCTCTACGTGGACTTACTGTTGTTTTTTTAATTATTA
TTGGAATGGGATTTTAGAAAATAGAAGTTACCTTTGTGTGTGTTTTAGGGAAGGTAGAGAAGAATCTGCTCTTTCTCTGAATACTGTTTT
GACCCCAGGCAGGACCTTGGAAAGGCCAAAACATTAACAGTAGTACTTCTGTTCACTGAAGAGTTATGTTACATGAAGATAAAATGGTTT

>73015_73015_1_RBMS1-ITGB6_RBMS1_chr2_161174680_ENST00000409075_ITGB6_chr2_160994710_ENST00000283249_length(amino acids)=418AA_BP=1
MRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEV
EVNSSKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGL
LCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQ
AREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIW

--------------------------------------------------------------
>73015_73015_2_RBMS1-ITGB6_RBMS1_chr2_161174680_ENST00000409289_ITGB6_chr2_160994710_ENST00000283249_length(transcript)=3606nt_BP=276nt
ATTTGCCTTCTCTTCACTTGGGGAGTATCAATTTGCCACAGCAGTCTCTGGTCCCAGCCCACCCCATGGCCCCTCCCAGTCCCAGCACCA
CCAGCAGTAATAACAACAGTAGCAGCAGTAGCAACTCAGGATGGGATCAGCTCAGCAAAACGAACCTCTATATCCGAGGACTGCCTCCCC
ACACCACCGACCAGGACCTGGTGAAGCTCTGTCAACCATATGGGAAAATAGTCTCCACAAAGGCAATTTTGGATAAGACAACGAACAAAT
GCAAAGGAACTGCGGTCTGAGGTGGAACTGGAAGTATTAGGAGACACTGAAGGACTCAACTTGTCATTTACAGCCATCTGTAACAACGGT
ACCCTCTTCCAACACCAAAAGAAATGCTCTCACATGAAAGTGGGAGACACAGCTTCCTTCAGCGTGACTGTGAATATCCCACACTGCGAG
AGAAGAAGCAGGCACATTATCATAAAGCCTGTGGGGCTGGGGGATGCCCTGGAATTACTTGTCAGCCCAGAATGCAACTGCGACTGTCAG
AAAGAAGTGGAAGTGAACAGCTCCAAATGTCACCACGGGAACGGCTCTTTCCAGTGTGGGGTGTGTGCCTGCCACCCTGGCCACATGGGG
CCTCGCTGTGAGTGTGGCGAGGACATGCTGAGCACAGATTCCTGCAAGGAGGCCCCAGATCATCCCTCCTGCAGCGGAAGGGGTGACTGC
TACTGTGGGCAGTGTATCTGCCACTTGTCTCCCTATGGAAACATTTATGGGCCTTATTGCCAGTGTGACAATTTCTCCTGCGTGAGACAC
AAAGGGCTGCTCTGCGGAGGTAACGGCGACTGTGACTGTGGTGAATGTGTGTGCAGGAGCGGCTGGACTGGCGAGTACTGCAACTGCACC
ACCAGCACGGACTCCTGCGTCTCTGAAGATGGAGTGCTCTGCAGCGGGCGCGGGGACTGTGTTTGTGGCAAGTGTGTTTGCACAAACCCT
GGAGCCTCAGGACCAACCTGTGAACGATGTCCTACCTGTGGTGACCCCTGTAACTCTAAACGGAGCTGCATTGAGTGCCACCTGTCAGCA
GCTGGCCAAGCCCGAGAAGAATGTGTGGACAAGTGCAAACTAGCTGGTGCGACCATCAGTGAAGAAGAAGATTTCTCAAAGGATGGTTCT
GTTTCCTGCTCTCTGCAAGGAGAAAATGAATGTCTTATTACATTCCTAATAACTACAGATAATGAGGGGAAAACCATCATTCACAGCATC
AATGAAAAAGATTGTCCGAAGCCTCCAAACATTCCCATGATCATGTTAGGGGTTTCCCTGGCTATTCTTCTCATCGGGGTTGTCCTACTG
TGCATCTGGAAGCTACTGGTGTCATTTCATGATCGTAAAGAAGTTGCCAAATTTGAAGCAGAACGATCAAAAGCCAAGTGGCAAACGGGA
ACCAATCCACTCTACAGAGGATCCACAAGTACTTTTAAAAATGTAACTTATAAACACAGGGAAAAACAAAAGGTAGACCTTTCCACAGAT
TGCTAGAACTACTTTATGCATGAAAAAAGTCTGTTTCACTGATATGAAATGTTAATGCACTATTTAATTTTTTTCTCTTTGTTGCTTCAA
AATGAGGTTGGTTTAAGATAATAATAGGACATCTGCAGATAAGTCATCCTCTACATGAAGGTGACAGACTGTTGGCAGTTTCAAAATAAT
CAAGAAGAGAAATATCCTTAGCAAAGAGATGACTTTGGGGATCATTTGAGGAATACTAACTCTGTTGCATTAATGCTTCAAAAAATCATC
AAATGATTCATGGGGGCCTGATTTGCATTTGAAAAATGTTTGAAATTAGAGTCTCATTTGTTTCAGGAATGCAGCTACCTGAGTTTTTTG
TCTCGGCAAAGTCACAAAGCCCATATACTCACATTGTGTGTCTATACTTGCCAATTAATTCTAAACTTGTAGGAAATATGCCCTCTCTTA
AAGGAGAATTTTTTTTAAATCTCTGAGAAATGAGATTCTGAGTTTATTTCAGCTAAAAGGTTGCAATTCTTCTGAAGATATCTCAAATAT
AAGGTTGAAAGTTAAGTGTTAATAATTTTTGTGAATTTATACACACCTAAACGTTAAGTACACAAATATTTTATTTGTTTTACAAATAAG
GAATAAGTAATTTATAAATTAAGAAGTTACCTATAAAAATAAAAAGATAACAACCCTATCATATAGCTTATTTTTAAATTACCTGAAAAA
CGATATTCTACACTGTTTCCTTTTTGACTCTGAGTTTTCAAACTGTTACTTCTCCCATATTTCTCAATCCATTTCACTCAGTTGCACAGT
CTTTTAAACCCTGTAATTGTCATACCAAAGTTTCTTTTTAAAAAAAAATTACTTTAAATGCTTAGTTTATTCAAAGAGCGATCCAATAAT
ATAAAAGGAACATGTGTTAAACACAATAAAATTTTAAATGGCTCTAAATCAAGCACATCAAGAGTATACAAGTCTTAAAGGCTTTTTAAT
ACATACTCTTTTCCCATCTATGTAACCCAACTTGCACATTTCAGCTGCATGTGGTGAATATGCATCATATATTTACTTTAAGAGGTAAGA
TTTTACTTGCAAAATACATGTGCAAATTAGGGATCCATCAGTTGATGGAAGAGATGGACTCTAGAATATTATTTCTTGTGGTTATTACTC
CTTTACAAAGCACTTTCGTCTCACTTGATCCTCATAAGGAAACTAAGGCTCAGAATGAGTAGAGCTGGGTTCAGAATCTAGCTCTTCTAA
CTCCAAGCCATCTCCTCTTTCCACTGCAGGAAACTGCCTCTTTTGTCAGTGAAATAATAGAAAGATTGTGTTAGTTAAGTGATAACTGTC
ATTTGTTTGAAAATGTTCGAGACTGAACAAATAGCATTTAAACTGCTGGCATATAGATGAGATATTGTACTTTTGTGCAATGTTTATTAC
CTTTGATTAAATTGTAATGTGAAGCTTTTACTAGGTGAATAGTTCATTATGTAGTGGAGGCTTCGTGGTTGTCCATTGAATTGTCACAGC
AAAATCTATAAGTTTCTTCAATTCTACAAGATAGATCCATATACCTTTGATCACTTGGAGACTCTTTTTTTGCTGGTTTCTAGATAACTC
AGGTAAATCAGACCTTTACAGAGTACAGGGCTAGGTGAAAGAATTACTGAAAAATCACCTTGAAAATCCGAAGGGCTGATATACCCTTTA
TGTTCCTGACTGATGCGCAGAACCTGGGGGAAATCTACAGCAATATACAGGTTGCAATGCTGATAACACAACAGCAATCCTCTCCTCTAC
GTGGACTTACTGTTGTTTTTTTAATTATTATTGGAATGGGATTTTAGAAAATAGAAGTTACCTTTGTGTGTGTTTTAGGGAAGGTAGAGA
AGAATCTGCTCTTTCTCTGAATACTGTTTTGACCCCAGGCAGGACCTTGGAAAGGCCAAAACATTAACAGTAGTACTTCTGTTCACTGAA
GAGTTATGTTACATGAAGATAAAATGGTTTTGTCGTGTTTATTATTGTATTTTGTGTTGATATAAATAAACATGGTAATTTAAACAATGA

>73015_73015_2_RBMS1-ITGB6_RBMS1_chr2_161174680_ENST00000409289_ITGB6_chr2_160994710_ENST00000283249_length(amino acids)=418AA_BP=1
MRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEV
EVNSSKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGL
LCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQ
AREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIW

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Fusion Gene PPI Analysis for RBMS1-ITGB6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneITGB6chr2:161174680chr2:160994710ENST00000283249715731_758369.0789.0HAX1
TgeneITGB6chr2:161174680chr2:160994710ENST00000409872816731_758369.0789.0HAX1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RBMS1-ITGB6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RBMS1-ITGB6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource