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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASXL2-DTNB (FusionGDB2 ID:7305)

Fusion Gene Summary for ASXL2-DTNB

check button Fusion gene summary
Fusion gene informationFusion gene name: ASXL2-DTNB
Fusion gene ID: 7305
HgeneTgene
Gene symbol

ASXL2

DTNB

Gene ID

55252

1838

Gene nameASXL transcriptional regulator 2dystrobrevin beta
SynonymsASXH2|SHAPNS-
Cytomap

2p23.3

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionputative Polycomb group protein ASXL2additional sex combs like 2, transcriptional regulatoradditional sex combs-like protein 2polycomb group protein ASXH2dystrobrevin betaDTN-Bbeta-dystrobrevin
Modification date2020031320200327
UniProtAcc

Q76L83

Q96EV8

Ensembl transtripts involved in fusion geneENST00000336112, ENST00000435504, 
ENST00000272341, ENST00000497092, 
ENST00000404843, 		ENST00000472690, 
ENST00000545439, ENST00000288642, 
ENST00000404103, ENST00000405222, 
ENST00000406818, ENST00000407038, 
ENST00000407186, ENST00000407661, 
ENST00000496972, 
Fusion gene scores* DoF score18 X 11 X 10=198014 X 13 X 9=1638
# samples 2415
** MAII scorelog2(24/1980*10)=-3.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1638*10)=-3.44890095114513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASXL2 [Title/Abstract] AND DTNB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDTNB(25818955)-ASXL2(25991737), # samples:3
ASXL2(26022254)-DTNB(25819109), # samples:1
Anticipated loss of major functional domain due to fusion event.ASXL2-DTNB seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ASXL2-DTNB seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ASXL2-DTNB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ASXL2-DTNB seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
DTNB-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DTNB-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
DTNB-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
DTNB-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASXL2

GO:0035360

positive regulation of peroxisome proliferator activated receptor signaling pathway

21047783

HgeneASXL2

GO:0045600

positive regulation of fat cell differentiation

21047783

HgeneASXL2

GO:0045944

positive regulation of transcription by RNA polymerase II

21047783


check buttonFusion gene breakpoints across ASXL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DTNB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-QK-A8Z9ASXL2chr2

26022254

-DTNBchr2

25819109

-


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Fusion Gene ORF analysis for ASXL2-DTNB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000336112ENST00000472690ASXL2chr2

26022254

-DTNBchr2

25819109

-
5CDS-5UTRENST00000435504ENST00000472690ASXL2chr2

26022254

-DTNBchr2

25819109

-
5CDS-intronENST00000336112ENST00000545439ASXL2chr2

26022254

-DTNBchr2

25819109

-
5CDS-intronENST00000435504ENST00000545439ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000272341ENST00000288642ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000272341ENST00000404103ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000272341ENST00000405222ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000272341ENST00000406818ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000272341ENST00000407038ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000272341ENST00000407186ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000272341ENST00000407661ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000272341ENST00000496972ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000497092ENST00000288642ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000497092ENST00000404103ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000497092ENST00000405222ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000497092ENST00000406818ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000497092ENST00000407038ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000497092ENST00000407186ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000497092ENST00000407661ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-3CDSENST00000497092ENST00000496972ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-5UTRENST00000272341ENST00000472690ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-5UTRENST00000497092ENST00000472690ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-intronENST00000272341ENST00000545439ASXL2chr2

26022254

-DTNBchr2

25819109

-
5UTR-intronENST00000497092ENST00000545439ASXL2chr2

26022254

-DTNBchr2

25819109

-
Frame-shiftENST00000336112ENST00000288642ASXL2chr2

26022254

-DTNBchr2

25819109

-
Frame-shiftENST00000336112ENST00000404103ASXL2chr2

26022254

-DTNBchr2

25819109

-
Frame-shiftENST00000336112ENST00000405222ASXL2chr2

26022254

-DTNBchr2

25819109

-
Frame-shiftENST00000336112ENST00000406818ASXL2chr2

26022254

-DTNBchr2

25819109

-
Frame-shiftENST00000336112ENST00000407038ASXL2chr2

26022254

-DTNBchr2

25819109

-
Frame-shiftENST00000336112ENST00000407186ASXL2chr2

26022254

-DTNBchr2

25819109

-
Frame-shiftENST00000336112ENST00000407661ASXL2chr2

26022254

-DTNBchr2

25819109

-
Frame-shiftENST00000336112ENST00000496972ASXL2chr2

26022254

-DTNBchr2

25819109

-
In-frameENST00000435504ENST00000288642ASXL2chr2

26022254

-DTNBchr2

25819109

-
In-frameENST00000435504ENST00000404103ASXL2chr2

26022254

-DTNBchr2

25819109

-
In-frameENST00000435504ENST00000405222ASXL2chr2

26022254

-DTNBchr2

25819109

-
In-frameENST00000435504ENST00000406818ASXL2chr2

26022254

-DTNBchr2

25819109

-
In-frameENST00000435504ENST00000407038ASXL2chr2

26022254

-DTNBchr2

25819109

-
In-frameENST00000435504ENST00000407186ASXL2chr2

26022254

-DTNBchr2

25819109

-
In-frameENST00000435504ENST00000407661ASXL2chr2

26022254

-DTNBchr2

25819109

-
In-frameENST00000435504ENST00000496972ASXL2chr2

26022254

-DTNBchr2

25819109

-
intron-3CDSENST00000404843ENST00000288642ASXL2chr2

26022254

-DTNBchr2

25819109

-
intron-3CDSENST00000404843ENST00000404103ASXL2chr2

26022254

-DTNBchr2

25819109

-
intron-3CDSENST00000404843ENST00000405222ASXL2chr2

26022254

-DTNBchr2

25819109

-
intron-3CDSENST00000404843ENST00000406818ASXL2chr2

26022254

-DTNBchr2

25819109

-
intron-3CDSENST00000404843ENST00000407038ASXL2chr2

26022254

-DTNBchr2

25819109

-
intron-3CDSENST00000404843ENST00000407186ASXL2chr2

26022254

-DTNBchr2

25819109

-
intron-3CDSENST00000404843ENST00000407661ASXL2chr2

26022254

-DTNBchr2

25819109

-
intron-3CDSENST00000404843ENST00000496972ASXL2chr2

26022254

-DTNBchr2

25819109

-
intron-5UTRENST00000404843ENST00000472690ASXL2chr2

26022254

-DTNBchr2

25819109

-
intron-intronENST00000404843ENST00000545439ASXL2chr2

26022254

-DTNBchr2

25819109

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000435504ASXL2chr226022254-ENST00000496972DTNBchr225819109-24436971532057634
ENST00000435504ASXL2chr226022254-ENST00000405222DTNBchr225819109-22726971531931592
ENST00000435504ASXL2chr226022254-ENST00000407661DTNBchr225819109-24196971532078641
ENST00000435504ASXL2chr226022254-ENST00000406818DTNBchr225819109-24736971532132659
ENST00000435504ASXL2chr226022254-ENST00000407038DTNBchr225819109-22936971531952599
ENST00000435504ASXL2chr226022254-ENST00000404103DTNBchr225819109-23836971532042629
ENST00000435504ASXL2chr226022254-ENST00000407186DTNBchr225819109-23476971532021622
ENST00000435504ASXL2chr226022254-ENST00000288642DTNBchr225819109-23646971532042629

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000435504ENST00000496972ASXL2chr226022254-DTNBchr225819109-0.044473520.9555265
ENST00000435504ENST00000405222ASXL2chr226022254-DTNBchr225819109-0.0431925770.95680743
ENST00000435504ENST00000407661ASXL2chr226022254-DTNBchr225819109-0.0416368770.9583631
ENST00000435504ENST00000406818ASXL2chr226022254-DTNBchr225819109-0.037415240.9625848
ENST00000435504ENST00000407038ASXL2chr226022254-DTNBchr225819109-0.0402284530.9597716
ENST00000435504ENST00000404103ASXL2chr226022254-DTNBchr225819109-0.0375687780.9624312
ENST00000435504ENST00000407186ASXL2chr226022254-DTNBchr225819109-0.0402270670.9597729
ENST00000435504ENST00000288642ASXL2chr226022254-DTNBchr225819109-0.0352789760.964721

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Fusion Genomic Features for ASXL2-DTNB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ASXL2-DTNB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:25818955/chr2:25991737)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASXL2

Q76L83

DTNB

Q96EV8

FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. {ECO:0000250, ECO:0000269|PubMed:21047783}.FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway. {ECO:0000269|PubMed:15345706, ECO:0000269|PubMed:16837549, ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:17989303, ECO:0000269|PubMed:19094965, ECO:0000269|PubMed:20180862, ECO:0000269|PubMed:20921223}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-51311_861341436.0DomainHTH HARE-type
TgeneDTNBchr2:26022254chr2:25819109ENST00000404103420428_529149607.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneDTNBchr2:26022254chr2:25819109ENST00000405222418428_529149570.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneDTNBchr2:26022254chr2:25819109ENST00000406818421428_529149637.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneDTNBchr2:26022254chr2:25819109ENST00000407038419428_529149577.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneDTNBchr2:26022254chr2:25819109ENST00000407661420428_529149619.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneDTNBchr2:26022254chr2:25819109ENST00000496972318428_52992581.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneDTNBchr2:26022254chr2:25819109ENST00000404103420399_448149607.3333333333334RegionNote=Syntrophin-binding region
TgeneDTNBchr2:26022254chr2:25819109ENST00000405222418399_448149570.3333333333334RegionNote=Syntrophin-binding region
TgeneDTNBchr2:26022254chr2:25819109ENST00000406818421399_448149637.3333333333334RegionNote=Syntrophin-binding region
TgeneDTNBchr2:26022254chr2:25819109ENST00000407038419399_448149577.3333333333334RegionNote=Syntrophin-binding region
TgeneDTNBchr2:26022254chr2:25819109ENST00000407661420399_448149619.3333333333334RegionNote=Syntrophin-binding region
TgeneDTNBchr2:26022254chr2:25819109ENST00000496972318399_44892581.3333333333334RegionNote=Syntrophin-binding region
TgeneDTNBchr2:26022254chr2:25819109ENST00000404103420237_284149607.3333333333334Zinc fingerZZ-type
TgeneDTNBchr2:26022254chr2:25819109ENST00000405222418237_284149570.3333333333334Zinc fingerZZ-type
TgeneDTNBchr2:26022254chr2:25819109ENST00000406818421237_284149637.3333333333334Zinc fingerZZ-type
TgeneDTNBchr2:26022254chr2:25819109ENST00000407038419237_284149577.3333333333334Zinc fingerZZ-type
TgeneDTNBchr2:26022254chr2:25819109ENST00000407661420237_284149619.3333333333334Zinc fingerZZ-type
TgeneDTNBchr2:26022254chr2:25819109ENST00000496972318237_28492581.3333333333334Zinc fingerZZ-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-4131173_11760919.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-413303_3070919.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-413654_6840919.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-413687_7390919.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-41395_2350919.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-1101173_11760919.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-110303_3070919.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-110654_6840919.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-110687_7390919.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-11095_2350919.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-5131173_11761341436.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-513303_3071341436.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-513654_6841341436.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-513687_7391341436.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-51395_2351341436.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-41311_860919.0DomainHTH HARE-type
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-413274_3830919.0DomainDEUBAD
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-11011_860919.0DomainHTH HARE-type
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-110274_3830919.0DomainDEUBAD
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-513274_3831341436.0DomainDEUBAD
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-413174_1780919.0MotifNuclear localization signal
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-413887_8910919.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-110174_1780919.0MotifNuclear localization signal
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-110887_8910919.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-513174_1781341436.0MotifNuclear localization signal
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-513887_8911341436.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-4131397_14340919.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-1101397_14340919.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-5131397_14341341436.0Zinc fingerNote=PHD-type%3B atypical


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Fusion Gene Sequence for ASXL2-DTNB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7305_7305_1_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000288642_length(transcript)=2364nt_BP=697nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAG
AACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGATGTTTTCTCCCAGATGTCAGAT
TCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAGGGCCATCTTTT
GGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCCT
CCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGA
TGTGAGAGTATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGC
GGCCCTCACAGCAACCAGCACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTG
GGGTGTGTACCCACGAGAGAACCCCCGCATCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGC
CCTCTGACTAATATGAATGACACCATGGTTAGCCACATGTCCTCTGGAGTGCCCACTCCCACCAAGAGGTTACAGTATAGCCAGGATATA
CCCAGTCACTTGGCCGATGAGCATGCGCTGATAGCCTCCTATGTGGCCCGTCTGCAGCACTGTGCACGTGTTCTGGACAGTCCTAGCCGA
CTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTGCAGAAGCAGGAAACGTGACTCGTCCTCCCACTGACTTGAGC
TTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTC
CGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAA
AGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTG
AAGGAAGCTGAGGCACGAGAATCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCA
GTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCA
CAAGCAGAGGAAGGTGCAGAGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTC
AGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCA
CACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCG
TGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCA

>7305_7305_1_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000288642_length(amino acids)=629AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGN
VTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMV

--------------------------------------------------------------
>7305_7305_2_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000404103_length(transcript)=2383nt_BP=697nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAG
AACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGATGTTTTCTCCCAGATGTCAGAT
TCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAGGGCCATCTTTT
GGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCCT
CCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGA
TGTGAGAGTATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGC
GGCCCTCACAGCAACCAGCACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTG
GGGTGTGTACCCACGAGAGAACCCCCGCATCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGC
CCTCTGACTAATATGAATGACACCATGGTTAGCCACATGTCCTCTGGAGTGCCCACTCCCACCAAGAGGTTACAGTATAGCCAGGATATA
CCCAGTCACTTGGCCGATGAGCATGCGCTGATAGCCTCCTATGTGGCCCGTCTGCAGCACTGTGCACGTGTTCTGGACAGTCCTAGCCGA
CTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTGCAGAAGCAGGAAACGTGACTCGTCCTCCCACTGACTTGAGC
TTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTC
CGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAA
AGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTG
AAGGAGGAAGAGCAAAAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCA
GTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCA
CAAGCAGAGGAAGGTGCAGAGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTC
AGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCA
CACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCG
TGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCA

>7305_7305_2_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000404103_length(amino acids)=629AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGN
VTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMV

--------------------------------------------------------------
>7305_7305_3_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000405222_length(transcript)=2272nt_BP=697nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAG
AACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGATGTTTTCTCCCAGATGTCAGAT
TCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAGGGCCATCTTTT
GGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCCT
CCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGA
TGTGAGAGTATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGC
GGCCCTCACAGCAACCAGCACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTG
GGGTGTGTACCCACGAGAGAACCCCCGCATCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGC
CCTCTGACTAATATGAATGACACCATGGTTAGCCACATGTCCTCTGGAGTGCCCACTCCCACCAAGAGTGTTCTGGACAGTCCTAGCCGA
CTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTGCAGAAGCAGGAAACGTGACTCGTCCTCCCACTGACTTGAGC
TTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTC
CGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAA
AGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTG
AAGGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGC
TCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGTGCAGAG
GAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCA
AGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGG
CTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCC
CCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGGTTGAA

>7305_7305_3_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000405222_length(amino acids)=592AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKSVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNR
EILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMP

--------------------------------------------------------------
>7305_7305_4_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000406818_length(transcript)=2473nt_BP=697nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAG
AACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGATGTTTTCTCCCAGATGTCAGAT
TCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAGGGCCATCTTTT
GGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCCT
CCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGA
TGTGAGAGTATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGC
GGCCCTCACAGCAACCAGCACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTG
GGGTGTGTACCCACGAGAGAACCCCCGCATCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGC
CCTCTGACTAATATGAATGACACCATGGTTAGCCACATGTCCTCTGGAGTGCCCACTCCCACCAAGAGGTTACAGTATAGCCAGGATATA
CCCAGTCACTTGGCCGATGAGCATGCGCTGATAGCCTCCTATGTGGCCCGTCTGCAGCACTGTGCACGTGTTCTGGACAGTCCTAGCCGA
CTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTGCAGAAGCAGGAAACGTGACTCGTCCTCCCACTGACTTGAGC
TTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTC
CGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAA
AGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTG
AAGGAGGAAGAGCAAAAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCA
GTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCA
CAAGGTACGAGGAGAAACCTCCGCAATGACCTGCTGGTGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCAT
TCAGCAGAGGAAGGTGCAGAGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTC
AGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCA
CACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCG
TGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCA

>7305_7305_4_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000406818_length(amino acids)=659AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGN
VTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMV
QLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNT

--------------------------------------------------------------
>7305_7305_5_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000407038_length(transcript)=2293nt_BP=697nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAG
AACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGATGTTTTCTCCCAGATGTCAGAT
TCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAGGGCCATCTTTT
GGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCCT
CCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGA
TGTGAGAGTATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGC
GGCCCTCACAGCAACCAGCACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTG
GGGTGTGTACCCACGAGAGAACCCCCGCATCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGC
CCTCTGACTAATATGAATGACACCATGGTTAGCCACATGTCCTCTGGAGTGCCCACTCCCACCAAGAGTGTTCTGGACAGTCCTAGCCGA
CTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTGCAGAAGCAGGAAACGTGACTCGTCCTCCCACTGACTTGAGC
TTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTC
CGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAA
AGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTG
AAGGAGGAAGAGCAAAAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCA
GTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCA
CAAGCAGAGGAAGGTGCAGAGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTC
AGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCA
CACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCG
TGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCA

>7305_7305_5_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000407038_length(amino acids)=599AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKSVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNR
EILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTH

--------------------------------------------------------------
>7305_7305_6_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000407186_length(transcript)=2347nt_BP=697nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAG
AACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGATGTTTTCTCCCAGATGTCAGAT
TCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAGGGCCATCTTTT
GGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCCT
CCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGA
TGTGAGAGTATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGC
GGCCCTCACAGCAACCAGCACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTG
GGGTGTGTACCCACGAGAGAACCCCCGCATCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGC
CCTCTGACTAATATGAATGACACCATGGTTAGCCACATGTCCTCTGGAGTGCCCACTCCCACCAAGAGTGTTCTGGACAGTCCTAGCCGA
CTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTGCAGAAGCAGGAAACGTGACTCGTCCTCCCACTGACTTGAGC
TTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTC
CGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAA
AGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTG
AAGGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGC
TCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAAACCTC
CGCAATGACCTGCTGGTGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGCAGAGGAAGGTGCAGAG
GAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCA
AGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGG
CTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCC
CCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGGTTGAA

>7305_7305_6_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000407186_length(amino acids)=622AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKSVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNR
EILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMP

--------------------------------------------------------------
>7305_7305_7_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000407661_length(transcript)=2419nt_BP=697nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAG
AACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGATGTTTTCTCCCAGATGTCAGAT
TCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAGGGCCATCTTTT
GGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCCT
CCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGA
TGTGAGAGTATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGC
GGCCCTCACAGCAACCAGCACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTG
GGGTGTGTACCCACGAGAGAACCCCCGCATCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGC
CCTCTGACTAATATGAATGACACCATGGTTAGCCACATGTCCTCTGGAGTGCCCACTCCCACCAAGAGGTTACAGTATAGCCAGGATATA
CCCAGTCACTTGGCCGATGAGCATGCGCTGATAGCCTCCTATGTGGCCCGTCTGCAGCACTGTGCACGTGTTCTGGACAGTCCTAGCCGA
CTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTGCAGAAGCAGGAAACGTGACTCGTCCTCCCACTGACTTGAGC
TTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTC
CGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAA
AGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTG
AAGGAGGAAGAGCAAAAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCA
GTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCA
CAAGGTACGAGGAGAAACCTCCGCAATGACCTGCTGGTGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCAT
TCAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTC
CCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGG
GGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCA

>7305_7305_7_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000407661_length(amino acids)=641AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGN
VTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMV
QLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNT

--------------------------------------------------------------
>7305_7305_8_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000496972_length(transcript)=2443nt_BP=697nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAG
AACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGATGTTTTCTCCCAGATGTCAGAT
TCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAGGGCCATCTTTT
GGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCCT
CCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGA
TGTGAGAGTATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGC
GGCCCTCACAGCAACCAGCACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTG
GGGTGTGTACCCACGAGAGAACCCCCGCATCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGC
CCTCTGACTAATATGAATGACACCATGGTTAGCCACATGTCCTCTGGAGTGCCCACTCCCACCAAGAGGTTACAGTATAGCCAGGATATA
CCCAGTCACTTGGCCGATGAGCATGCGCTGATAGCCTCCTATGTGGCCCGTCTGCAGCACTGTGCACGTGTTCTGGACAGTCCTAGCCGA
CTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTGCAGAAGCAGGAAACGTGACTCGTCCTCCCACTGACTTGAGC
TTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTC
CGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAA
AGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTG
AAGGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGC
TCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAAACCTC
CGCAATGACCTGCTGGTGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGGTTAGCAGAGGAGCCGG
ACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTC
CATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAG
CGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGT
CTCATCTCCGCATCAGGAATTCACCTGGAGGTTGAAAAGAGAAAAGAAAAAGCACCAAGCTCTTGTGTGTTTGTGACCTGATGAAACACT

>7305_7305_8_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000496972_length(amino acids)=634AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGN
VTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMV
QLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNTMSSLVKE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ASXL2-DTNB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASXL2-DTNB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASXL2-DTNB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource