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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RBPJ-SEL1L3 (FusionGDB2 ID:73079)

Fusion Gene Summary for RBPJ-SEL1L3

check button Fusion gene summary
Fusion gene informationFusion gene name: RBPJ-SEL1L3
Fusion gene ID: 73079
HgeneTgene
Gene symbol

RBPJ

SEL1L3

Gene ID

3516

23231

Gene namerecombination signal binding protein for immunoglobulin kappa J regionSEL1L family member 3
SynonymsAOS3|CBF1|IGKJRB|IGKJRB1|KBF2|RBP-J|RBPJK|RBPSUH|SUH|cslSel-1L3
Cytomap

4p15.2

4p15.2

Type of geneprotein-codingprotein-coding
Descriptionrecombining binding protein suppressor of hairlessCBF-1H-2K binding factor-2RBP-J kappaRBP-JKimmunoglobulin kappa J region recombination signal binding protein 1renal carcinoma antigen NY-REN-30suppressor of hairless homologprotein sel-1 homolog 3sel-1 suppressor of lin-12-like 3suppressor of lin-12-like protein 3
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000511401, ENST00000348160, 
ENST00000355476, ENST00000342295, 
ENST00000342320, ENST00000345843, 
ENST00000361572, ENST00000504907, 
ENST00000507561, 		ENST00000264868, 
ENST00000399878, ENST00000502949, 
ENST00000513364, 
Fusion gene scores* DoF score15 X 12 X 6=10806 X 6 X 5=180
# samples 166
** MAII scorelog2(16/1080*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBPJ [Title/Abstract] AND SEL1L3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRBPJ(26322670)-SEL1L3(25835191), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRBPJ

GO:0007221

positive regulation of transcription of Notch receptor target

21102556

HgeneRBPJ

GO:0045892

negative regulation of transcription, DNA-templated

10713164

HgeneRBPJ

GO:0061419

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

23303788


check buttonFusion gene breakpoints across RBPJ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SEL1L3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-HB-A3YV-01ARBPJchr4

26322670

-SEL1L3chr4

25835191

-
ChimerDB4SARCTCGA-HB-A3YV-01ARBPJchr4

26322670

+SEL1L3chr4

25835191

-


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Fusion Gene ORF analysis for RBPJ-SEL1L3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000511401ENST00000264868RBPJchr4

26322670

+SEL1L3chr4

25835191

-
3UTR-3CDSENST00000511401ENST00000399878RBPJchr4

26322670

+SEL1L3chr4

25835191

-
3UTR-3CDSENST00000511401ENST00000502949RBPJchr4

26322670

+SEL1L3chr4

25835191

-
3UTR-5UTRENST00000511401ENST00000513364RBPJchr4

26322670

+SEL1L3chr4

25835191

-
5CDS-5UTRENST00000348160ENST00000513364RBPJchr4

26322670

+SEL1L3chr4

25835191

-
5UTR-3CDSENST00000355476ENST00000264868RBPJchr4

26322670

+SEL1L3chr4

25835191

-
5UTR-3CDSENST00000355476ENST00000399878RBPJchr4

26322670

+SEL1L3chr4

25835191

-
5UTR-3CDSENST00000355476ENST00000502949RBPJchr4

26322670

+SEL1L3chr4

25835191

-
5UTR-5UTRENST00000355476ENST00000513364RBPJchr4

26322670

+SEL1L3chr4

25835191

-
In-frameENST00000348160ENST00000264868RBPJchr4

26322670

+SEL1L3chr4

25835191

-
In-frameENST00000348160ENST00000399878RBPJchr4

26322670

+SEL1L3chr4

25835191

-
In-frameENST00000348160ENST00000502949RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000342295ENST00000264868RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000342295ENST00000399878RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000342295ENST00000502949RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000342320ENST00000264868RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000342320ENST00000399878RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000342320ENST00000502949RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000345843ENST00000264868RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000345843ENST00000399878RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000345843ENST00000502949RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000361572ENST00000264868RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000361572ENST00000399878RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000361572ENST00000502949RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000504907ENST00000264868RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000504907ENST00000399878RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000504907ENST00000502949RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000507561ENST00000264868RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000507561ENST00000399878RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-3CDSENST00000507561ENST00000502949RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-5UTRENST00000342295ENST00000513364RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-5UTRENST00000342320ENST00000513364RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-5UTRENST00000345843ENST00000513364RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-5UTRENST00000361572ENST00000513364RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-5UTRENST00000504907ENST00000513364RBPJchr4

26322670

+SEL1L3chr4

25835191

-
intron-5UTRENST00000507561ENST00000513364RBPJchr4

26322670

+SEL1L3chr4

25835191

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000348160RBPJchr426322670+ENST00000399878SEL1L3chr425835191-37802492202787855
ENST00000348160RBPJchr426322670+ENST00000264868SEL1L3chr425835191-37802492202787855
ENST00000348160RBPJchr426322670+ENST00000502949SEL1L3chr425835191-29472492202787855

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000348160ENST00000399878RBPJchr426322670+SEL1L3chr425835191-0.000736440.9992636
ENST00000348160ENST00000264868RBPJchr426322670+SEL1L3chr425835191-0.000736440.9992636
ENST00000348160ENST00000502949RBPJchr426322670+SEL1L3chr425835191-0.0021806390.9978193

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Fusion Genomic Features for RBPJ-SEL1L3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RBPJ-SEL1L3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:26322670/chr4:25835191)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000264868224575_6092511098.0RepeatNote=Sel1-like 1
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000264868224611_6472511098.0RepeatNote=Sel1-like 2
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000264868224694_7302511098.0RepeatNote=Sel1-like 3
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000264868224732_7672511098.0RepeatNote=Sel1-like 4
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000264868224768_8002511098.0RepeatNote=Sel1-like 5
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000264868224801_8392511098.0RepeatNote=Sel1-like 6
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000264868224840_8772511098.0RepeatNote=Sel1-like 7
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000264868224952_9882511098.0RepeatNote=Sel1-like 8
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000399878224575_6092861133.0RepeatNote=Sel1-like 1
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000399878224611_6472861133.0RepeatNote=Sel1-like 2
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000399878224694_7302861133.0RepeatNote=Sel1-like 3
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000399878224732_7672861133.0RepeatNote=Sel1-like 4
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000399878224768_8002861133.0RepeatNote=Sel1-like 5
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000399878224801_8392861133.0RepeatNote=Sel1-like 6
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000399878224840_8772861133.0RepeatNote=Sel1-like 7
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000399878224952_9882861133.0RepeatNote=Sel1-like 8
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000502949224575_609133980.0RepeatNote=Sel1-like 1
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000502949224611_647133980.0RepeatNote=Sel1-like 2
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000502949224694_730133980.0RepeatNote=Sel1-like 3
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000502949224732_767133980.0RepeatNote=Sel1-like 4
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000502949224768_800133980.0RepeatNote=Sel1-like 5
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000502949224801_839133980.0RepeatNote=Sel1-like 6
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000502949224840_877133980.0RepeatNote=Sel1-like 7
TgeneSEL1L3chr4:26322670chr4:25835191ENST00000502949224952_988133980.0RepeatNote=Sel1-like 8
TgeneSEL1L3chr4:26322670chr4:25835191ENST000002648682241057_10772511098.0TransmembraneHelical
TgeneSEL1L3chr4:26322670chr4:25835191ENST000003998782241057_10772861133.0TransmembraneHelical
TgeneSEL1L3chr4:26322670chr4:25835191ENST000005029492241057_1077133980.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRBPJchr4:26322670chr4:25835191ENST00000342295+112355_4450501.0DomainNote=IPT/TIG
HgeneRBPJchr4:26322670chr4:25835191ENST00000342320+111355_4450487.0DomainNote=IPT/TIG
HgeneRBPJchr4:26322670chr4:25835191ENST00000345843+111355_4450486.0DomainNote=IPT/TIG
HgeneRBPJchr4:26322670chr4:25835191ENST00000348160+111355_4456488.0DomainNote=IPT/TIG
HgeneRBPJchr4:26322670chr4:25835191ENST00000355476+112355_4450487.0DomainNote=IPT/TIG
HgeneRBPJchr4:26322670chr4:25835191ENST00000361572+111355_4450501.0DomainNote=IPT/TIG
HgeneRBPJchr4:26322670chr4:25835191ENST00000507561+111355_4450466.0DomainNote=IPT/TIG
HgeneRBPJchr4:26322670chr4:25835191ENST00000342295+112165_1700501.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000342295+112192_1970501.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000342295+11257_670501.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000342320+111165_1700487.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000342320+111192_1970487.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000342320+11157_670487.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000345843+111165_1700486.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000345843+111192_1970486.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000345843+11157_670486.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000348160+111165_1706488.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000348160+111192_1976488.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000348160+11157_676488.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000355476+112165_1700487.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000355476+112192_1970487.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000355476+11257_670487.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000361572+111165_1700501.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000361572+111192_1970501.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000361572+11157_670501.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000507561+111165_1700466.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000507561+111192_1970466.0RegionDNA binding
HgeneRBPJchr4:26322670chr4:25835191ENST00000507561+11157_670466.0RegionDNA binding


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Fusion Gene Sequence for RBPJ-SEL1L3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>73079_73079_1_RBPJ-SEL1L3_RBPJ_chr4_26322670_ENST00000348160_SEL1L3_chr4_25835191_ENST00000264868_length(transcript)=3780nt_BP=249nt
ATGCTCCATCGCCTGGGTAGGTTTCCAGGGAAGGCAGCGAGCAGGATCCCCTACTCTGCGGGCGGCGCGAGGCGTCTGGCTCTTCGCGGC
GGCGGCGAGGGGAAAGGGAGCGCGGGGGCTGGGTGGAATCGAGGAGTGAGGAAAAAGGGAAGGGGCGGGGGAGAGGGACCAGGGAAGGCG
TCGGGGGGAATCTCGCGAGGGTTGGAGTTTTGGCGAGAGTTTGTGGAAGATGGCGCCTGTTGTGACAGGGTTTACTGTTTCATTGTGGCT
TTATTTACTCCATTATTGCAAGGCCAACCTCTGTGGGATTCTGTACTTTGTTGACTCTAATGAGATGTACGGCACACCTTCTGTATTTCT
TACGGAAGAGGGCTATTTGCATATTCAGATGCATCTTGTCAAAGGGGAAGACCTTGCTGTAAAAACTAAATTCATCATACCTTTGAAGGA
GTGGTTTCGACTGGATATCTCTTTTAACGGAGGCCAGATAGTAGTAACCACTAGCATTGGACAGGATTTGAAAAGCTACCACAATCAGAC
CATTAGCTTCCGGGAGGATTTCCATTATAATGACACAGCTGGGTACTTCATTATTGGAGGGAGCAGGTATGTGGCTGGCATTGAAGGGTT
TTTTGGACCCCTGAAGTACTATCGCCTTCGCAGTCTGCACCCCGCCCAGATTTTTAATCCCCTCCTTGAGAAGCAACTTGCTGAACAAAT
CAAGTTATATTATGAAAGGTGTGCTGAGGTTCAAGAAATAGTATCTGTGTATGCATCTGCAGCAAAGCACGGGGGCGAGAGACAAGAAGC
ATGCCACCTCCACAACTCCTACCTGGACCTCCAGCGCAGGTATGGGAGACCCTCGATGTGCAGAGCCTTCCCCTGGGAGAAGGAGCTGAA
AGACAAACACCCCAGCTTGTTCCAGGCATTGCTGGAGATGGATCTGCTGACCGTGCCAAGGAACCAAAATGAATCTGTATCAGAAATCGG
TGGGAAGATATTTGAGAAGGCTGTAAAGAGACTCTCTAGCATTGATGGTCTTCACCAAATTAGCTCTATCGTCCCCTTTCTGACGGATTC
CAGCTGCTGTGGATACCATAAAGCATCCTACTACCTTGCAGTCTTTTATGAGACTGGATTAAATGTTCCTCGGGATCAGCTGCAGGGCAT
GTTGTATAGTTTGGTTGGAGGCCAGGGGAGTGAGAGGCTGTCTTCAATGAATCTTGGGTATAAACACTACCAGGGTATTGACAACTACCC
CCTGGACTGGGAACTGTCGTATGCCTACTACAGCAACATTGCCACCAAGACACCCCTTGACCAGCACACACTGCAAGGAGATCAGGCATA
TGTTGAAACAATTAGACTAAAAGATGATGAAATACTCAAGGTACAAACCAAAGAAGATGGAGATGTCTTTATGTGGTTGAAGCATGAAGC
TACCCGAGGCAATGCAGCAGCTCAGCAACGATTGGCCCAGATGCTGTTCTGGGGGCAGCAAGGTGTGGCCAAGAATCCCGAAGCAGCAAT
TGAGTGGTACGCCAAGGGCGCCCTGGAGACGGAGGATCCTGCGTTAATCTATGACTATGCCATTGTGCTATTCAAGGGTCAAGGAGTAAA
AAAGAACAGACGGCTTGCCTTAGAGCTGATGAAGAAAGCAGCTTCCAAGGGATTGCATCAGGCAGTCAATGGCCTGGGATGGTATTACCA
CAAATTCAAGAAAAATTACGCCAAAGCAGCAAAGTACTGGTTAAAAGCAGAAGAAATGGGGAACCCAGATGCGTCATACAATCTTGGAGT
CCTGCATTTGGATGGCATCTTCCCTGGAGTTCCTGGAAGGAATCAAACTTTAGCTGGTGAATATTTCCATAAGGCTGCGCAAGGTGGACA
CATGGAAGGGACCTTGTGGTGTTCTCTCTACTATATCACAGGCAACCTGGAGACATTCCCTAGAGATCCTGAGAAAGCTGTTGTATGGGC
AAAACATGTAGCTGAGAAAAATGGCTACTTGGGCCATGTCATCCGCAAAGGCCTCAATGCCTACCTGGAAGGTTCATGGCATGAAGCTTT
GCTGTATTATGTTTTAGCAGCAGAAACTGGAATTGAAGTGTCACAGACAAATTTAGCACACATCTGTGAGGAGAGGCCAGACCTGGCCAG
GAGATACTTGGGTGTTAACTGTGTTTGGAGATACTATAATTTCTCTGTTTTTCAAATCGATGCTCCTTCCTTTGCATATTTGAAGATGGG
AGACCTTTACTACTATGGCCACCAAAACCAGTCACAAGACCTGGAGTTGTCTGTGCAGATGTACGCCCAAGCCGCCCTGGATGGAGACTC
CCAGGGATTTTTTAACCTGGCCCTGCTAATCGAGGAAGGTACGATAATCCCACACCATATCTTGGATTTCTTGGAAATTGACTCAACTCT
CCATTCTAATAACATCTCCATTCTCCAGGAACTGTACGAAAGGTGCTGGAGCCACAGTAACGAGGAGTCCTTCAGCCCCTGCTCCTTGGC
CTGGCTTTACCTGCACTTGCGGCTTCTCTGGGGTGCTATCCTGCACTCAGCCCTGATCTACTTTCTGGGAACCTTTCTGCTATCCATATT
GATCGCCTGGACTGTGCAGTATTTCCAGTCTGTCTCAGCAAGCGATCCCCCTCCAAGACCATCCCAGGCCTCCCCAGACACTGCCACGTC
CACTGCAAGTCCAGCTGTGACTCCAGCTGCAGATGCCTCTGACCAAGACCAGCCCACAGTAACTAATAACCCGGAGCCACGTGGGTGAAC
TGTGCACTCCAGTTCTCTCCAGATGAGAGAGAATCTTTTCAACAGCTGGTATTGGGAAGCTGGGGCCAGGGCATGATCCTGATAAACACC
TTAAATGTCTTGTCAACTGGATGCAAATTTTGCAATTGGTGTCATTTTTTTTAAAGTCAAATTACAAGGAAGTACCCAGATCAGGCAGTG
GTAATACCAAAGGTCATCAAACACATACAAGGAACATCTTGATCATAGGGCATGTGGGGAAGTTTACTGGGCCATCACAGACTTTTGTTC
TAGTGATTGTATGTATTAGGAGTCATAGCATGCCCTACGGCAGATCTGGATTCTTATACACTAAGATGTGTCTTAAGAATCACAGTGCGT
GCTTCATCCCTTTATTGAAGAACAGAAAATTATGACTACTCTACAAGGTGGATAATATTTTGGTACCTGTGCTTGCCACAGCCCTGTTCC
TCAAAGCTGAATTGATAGATTTCTCTTTGACTTCCAAGACCTAGCAGTTATAAGGCACCTTGAAATAAATTGTTTGTGCCTGGAAATGCA
GGGAGGGCAATAGCTTTGTAAATTGGTTTACATTTTTCTCCTTGAATTTTTCTAGGGTCCTAGTGCTTCCGAATCATTTAATGGCATTGT
CGGATATCTTTTACATTTCAATTGCAATCCATGAAATTACATTTAGAAGATTCTTAGTACTTAACTGTAGTCTTCTCCATGAATTACACG
TTAGAATAGACTGGCAGCAACGGAATATGCAGCAAGTAAGCCTCTAGCTTATAGTTTCATCCCTACCCCTCATGCCTGCGTGAGTCTGTA
CAGGGATATGTGTGTGTGTGTGTGTGTGTGTGTGTTAGAGAGGAAGAGGAAGAGCAGAATGTCTGTATACTACATGCTGCTAAGGTAGTG
AATAAATCAGTAATGCAATATTGTGGGTCCAAACTACTCTTTGCACTACTTTATTTACAGTAGTAAATAAAATTATTTTTATACAATTGA

>73079_73079_1_RBPJ-SEL1L3_RBPJ_chr4_26322670_ENST00000348160_SEL1L3_chr4_25835191_ENST00000264868_length(amino acids)=855AA_BP=10
MWKMAPVVTGFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVKTKFIIPLKEWFRLDISFNGGQI
VVTTSIGQDLKSYHNQTISFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPLLEKQLAEQIKLYYERCAEVQEI
VSVYASAAKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRNQNESVSEIGGKIFEKAVKRLSS
IDGLHQISSIVPFLTDSSCCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGIDNYPLDWELSYAYYSNI
ATKTPLDQHTLQGDQAYVETIRLKDDEILKVQTKEDGDVFMWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDP
ALIYDYAIVLFKGQGVKKNRRLALELMKKAASKGLHQAVNGLGWYYHKFKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIFPGVPGR
NQTLAGEYFHKAAQGGHMEGTLWCSLYYITGNLETFPRDPEKAVVWAKHVAEKNGYLGHVIRKGLNAYLEGSWHEALLYYVLAAETGIEV
SQTNLAHICEERPDLARRYLGVNCVWRYYNFSVFQIDAPSFAYLKMGDLYYYGHQNQSQDLELSVQMYAQAALDGDSQGFFNLALLIEEG
TIIPHHILDFLEIDSTLHSNNISILQELYERCWSHSNEESFSPCSLAWLYLHLRLLWGAILHSALIYFLGTFLLSILIAWTVQYFQSVSA

--------------------------------------------------------------
>73079_73079_2_RBPJ-SEL1L3_RBPJ_chr4_26322670_ENST00000348160_SEL1L3_chr4_25835191_ENST00000399878_length(transcript)=3780nt_BP=249nt
ATGCTCCATCGCCTGGGTAGGTTTCCAGGGAAGGCAGCGAGCAGGATCCCCTACTCTGCGGGCGGCGCGAGGCGTCTGGCTCTTCGCGGC
GGCGGCGAGGGGAAAGGGAGCGCGGGGGCTGGGTGGAATCGAGGAGTGAGGAAAAAGGGAAGGGGCGGGGGAGAGGGACCAGGGAAGGCG
TCGGGGGGAATCTCGCGAGGGTTGGAGTTTTGGCGAGAGTTTGTGGAAGATGGCGCCTGTTGTGACAGGGTTTACTGTTTCATTGTGGCT
TTATTTACTCCATTATTGCAAGGCCAACCTCTGTGGGATTCTGTACTTTGTTGACTCTAATGAGATGTACGGCACACCTTCTGTATTTCT
TACGGAAGAGGGCTATTTGCATATTCAGATGCATCTTGTCAAAGGGGAAGACCTTGCTGTAAAAACTAAATTCATCATACCTTTGAAGGA
GTGGTTTCGACTGGATATCTCTTTTAACGGAGGCCAGATAGTAGTAACCACTAGCATTGGACAGGATTTGAAAAGCTACCACAATCAGAC
CATTAGCTTCCGGGAGGATTTCCATTATAATGACACAGCTGGGTACTTCATTATTGGAGGGAGCAGGTATGTGGCTGGCATTGAAGGGTT
TTTTGGACCCCTGAAGTACTATCGCCTTCGCAGTCTGCACCCCGCCCAGATTTTTAATCCCCTCCTTGAGAAGCAACTTGCTGAACAAAT
CAAGTTATATTATGAAAGGTGTGCTGAGGTTCAAGAAATAGTATCTGTGTATGCATCTGCAGCAAAGCACGGGGGCGAGAGACAAGAAGC
ATGCCACCTCCACAACTCCTACCTGGACCTCCAGCGCAGGTATGGGAGACCCTCGATGTGCAGAGCCTTCCCCTGGGAGAAGGAGCTGAA
AGACAAACACCCCAGCTTGTTCCAGGCATTGCTGGAGATGGATCTGCTGACCGTGCCAAGGAACCAAAATGAATCTGTATCAGAAATCGG
TGGGAAGATATTTGAGAAGGCTGTAAAGAGACTCTCTAGCATTGATGGTCTTCACCAAATTAGCTCTATCGTCCCCTTTCTGACGGATTC
CAGCTGCTGTGGATACCATAAAGCATCCTACTACCTTGCAGTCTTTTATGAGACTGGATTAAATGTTCCTCGGGATCAGCTGCAGGGCAT
GTTGTATAGTTTGGTTGGAGGCCAGGGGAGTGAGAGGCTGTCTTCAATGAATCTTGGGTATAAACACTACCAGGGTATTGACAACTACCC
CCTGGACTGGGAACTGTCGTATGCCTACTACAGCAACATTGCCACCAAGACACCCCTTGACCAGCACACACTGCAAGGAGATCAGGCATA
TGTTGAAACAATTAGACTAAAAGATGATGAAATACTCAAGGTACAAACCAAAGAAGATGGAGATGTCTTTATGTGGTTGAAGCATGAAGC
TACCCGAGGCAATGCAGCAGCTCAGCAACGATTGGCCCAGATGCTGTTCTGGGGGCAGCAAGGTGTGGCCAAGAATCCCGAAGCAGCAAT
TGAGTGGTACGCCAAGGGCGCCCTGGAGACGGAGGATCCTGCGTTAATCTATGACTATGCCATTGTGCTATTCAAGGGTCAAGGAGTAAA
AAAGAACAGACGGCTTGCCTTAGAGCTGATGAAGAAAGCAGCTTCCAAGGGATTGCATCAGGCAGTCAATGGCCTGGGATGGTATTACCA
CAAATTCAAGAAAAATTACGCCAAAGCAGCAAAGTACTGGTTAAAAGCAGAAGAAATGGGGAACCCAGATGCGTCATACAATCTTGGAGT
CCTGCATTTGGATGGCATCTTCCCTGGAGTTCCTGGAAGGAATCAAACTTTAGCTGGTGAATATTTCCATAAGGCTGCGCAAGGTGGACA
CATGGAAGGGACCTTGTGGTGTTCTCTCTACTATATCACAGGCAACCTGGAGACATTCCCTAGAGATCCTGAGAAAGCTGTTGTATGGGC
AAAACATGTAGCTGAGAAAAATGGCTACTTGGGCCATGTCATCCGCAAAGGCCTCAATGCCTACCTGGAAGGTTCATGGCATGAAGCTTT
GCTGTATTATGTTTTAGCAGCAGAAACTGGAATTGAAGTGTCACAGACAAATTTAGCACACATCTGTGAGGAGAGGCCAGACCTGGCCAG
GAGATACTTGGGTGTTAACTGTGTTTGGAGATACTATAATTTCTCTGTTTTTCAAATCGATGCTCCTTCCTTTGCATATTTGAAGATGGG
AGACCTTTACTACTATGGCCACCAAAACCAGTCACAAGACCTGGAGTTGTCTGTGCAGATGTACGCCCAAGCCGCCCTGGATGGAGACTC
CCAGGGATTTTTTAACCTGGCCCTGCTAATCGAGGAAGGTACGATAATCCCACACCATATCTTGGATTTCTTGGAAATTGACTCAACTCT
CCATTCTAATAACATCTCCATTCTCCAGGAACTGTACGAAAGGTGCTGGAGCCACAGTAACGAGGAGTCCTTCAGCCCCTGCTCCTTGGC
CTGGCTTTACCTGCACTTGCGGCTTCTCTGGGGTGCTATCCTGCACTCAGCCCTGATCTACTTTCTGGGAACCTTTCTGCTATCCATATT
GATCGCCTGGACTGTGCAGTATTTCCAGTCTGTCTCAGCAAGCGATCCCCCTCCAAGACCATCCCAGGCCTCCCCAGACACTGCCACGTC
CACTGCAAGTCCAGCTGTGACTCCAGCTGCAGATGCCTCTGACCAAGACCAGCCCACAGTAACTAATAACCCGGAGCCACGTGGGTGAAC
TGTGCACTCCAGTTCTCTCCAGATGAGAGAGAATCTTTTCAACAGCTGGTATTGGGAAGCTGGGGCCAGGGCATGATCCTGATAAACACC
TTAAATGTCTTGTCAACTGGATGCAAATTTTGCAATTGGTGTCATTTTTTTTAAAGTCAAATTACAAGGAAGTACCCAGATCAGGCAGTG
GTAATACCAAAGGTCATCAAACACATACAAGGAACATCTTGATCATAGGGCATGTGGGGAAGTTTACTGGGCCATCACAGACTTTTGTTC
TAGTGATTGTATGTATTAGGAGTCATAGCATGCCCTACGGCAGATCTGGATTCTTATACACTAAGATGTGTCTTAAGAATCACAGTGCGT
GCTTCATCCCTTTATTGAAGAACAGAAAATTATGACTACTCTACAAGGTGGATAATATTTTGGTACCTGTGCTTGCCACAGCCCTGTTCC
TCAAAGCTGAATTGATAGATTTCTCTTTGACTTCCAAGACCTAGCAGTTATAAGGCACCTTGAAATAAATTGTTTGTGCCTGGAAATGCA
GGGAGGGCAATAGCTTTGTAAATTGGTTTACATTTTTCTCCTTGAATTTTTCTAGGGTCCTAGTGCTTCCGAATCATTTAATGGCATTGT
CGGATATCTTTTACATTTCAATTGCAATCCATGAAATTACATTTAGAAGATTCTTAGTACTTAACTGTAGTCTTCTCCATGAATTACACG
TTAGAATAGACTGGCAGCAACGGAATATGCAGCAAGTAAGCCTCTAGCTTATAGTTTCATCCCTACCCCTCATGCCTGCGTGAGTCTGTA
CAGGGATATGTGTGTGTGTGTGTGTGTGTGTGTGTTAGAGAGGAAGAGGAAGAGCAGAATGTCTGTATACTACATGCTGCTAAGGTAGTG
AATAAATCAGTAATGCAATATTGTGGGTCCAAACTACTCTTTGCACTACTTTATTTACAGTAGTAAATAAAATTATTTTTATACAATTGA

>73079_73079_2_RBPJ-SEL1L3_RBPJ_chr4_26322670_ENST00000348160_SEL1L3_chr4_25835191_ENST00000399878_length(amino acids)=855AA_BP=10
MWKMAPVVTGFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVKTKFIIPLKEWFRLDISFNGGQI
VVTTSIGQDLKSYHNQTISFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPLLEKQLAEQIKLYYERCAEVQEI
VSVYASAAKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRNQNESVSEIGGKIFEKAVKRLSS
IDGLHQISSIVPFLTDSSCCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGIDNYPLDWELSYAYYSNI
ATKTPLDQHTLQGDQAYVETIRLKDDEILKVQTKEDGDVFMWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDP
ALIYDYAIVLFKGQGVKKNRRLALELMKKAASKGLHQAVNGLGWYYHKFKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIFPGVPGR
NQTLAGEYFHKAAQGGHMEGTLWCSLYYITGNLETFPRDPEKAVVWAKHVAEKNGYLGHVIRKGLNAYLEGSWHEALLYYVLAAETGIEV
SQTNLAHICEERPDLARRYLGVNCVWRYYNFSVFQIDAPSFAYLKMGDLYYYGHQNQSQDLELSVQMYAQAALDGDSQGFFNLALLIEEG
TIIPHHILDFLEIDSTLHSNNISILQELYERCWSHSNEESFSPCSLAWLYLHLRLLWGAILHSALIYFLGTFLLSILIAWTVQYFQSVSA

--------------------------------------------------------------
>73079_73079_3_RBPJ-SEL1L3_RBPJ_chr4_26322670_ENST00000348160_SEL1L3_chr4_25835191_ENST00000502949_length(transcript)=2947nt_BP=249nt
ATGCTCCATCGCCTGGGTAGGTTTCCAGGGAAGGCAGCGAGCAGGATCCCCTACTCTGCGGGCGGCGCGAGGCGTCTGGCTCTTCGCGGC
GGCGGCGAGGGGAAAGGGAGCGCGGGGGCTGGGTGGAATCGAGGAGTGAGGAAAAAGGGAAGGGGCGGGGGAGAGGGACCAGGGAAGGCG
TCGGGGGGAATCTCGCGAGGGTTGGAGTTTTGGCGAGAGTTTGTGGAAGATGGCGCCTGTTGTGACAGGGTTTACTGTTTCATTGTGGCT
TTATTTACTCCATTATTGCAAGGCCAACCTCTGTGGGATTCTGTACTTTGTTGACTCTAATGAGATGTACGGCACACCTTCTGTATTTCT
TACGGAAGAGGGCTATTTGCATATTCAGATGCATCTTGTCAAAGGGGAAGACCTTGCTGTAAAAACTAAATTCATCATACCTTTGAAGGA
GTGGTTTCGACTGGATATCTCTTTTAACGGAGGCCAGATAGTAGTAACCACTAGCATTGGACAGGATTTGAAAAGCTACCACAATCAGAC
CATTAGCTTCCGGGAGGATTTCCATTATAATGACACAGCTGGGTACTTCATTATTGGAGGGAGCAGGTATGTGGCTGGCATTGAAGGGTT
TTTTGGACCCCTGAAGTACTATCGCCTTCGCAGTCTGCACCCCGCCCAGATTTTTAATCCCCTCCTTGAGAAGCAACTTGCTGAACAAAT
CAAGTTATATTATGAAAGGTGTGCTGAGGTTCAAGAAATAGTATCTGTGTATGCATCTGCAGCAAAGCACGGGGGCGAGAGACAAGAAGC
ATGCCACCTCCACAACTCCTACCTGGACCTCCAGCGCAGGTATGGGAGACCCTCGATGTGCAGAGCCTTCCCCTGGGAGAAGGAGCTGAA
AGACAAACACCCCAGCTTGTTCCAGGCATTGCTGGAGATGGATCTGCTGACCGTGCCAAGGAACCAAAATGAATCTGTATCAGAAATCGG
TGGGAAGATATTTGAGAAGGCTGTAAAGAGACTCTCTAGCATTGATGGTCTTCACCAAATTAGCTCTATCGTCCCCTTTCTGACGGATTC
CAGCTGCTGTGGATACCATAAAGCATCCTACTACCTTGCAGTCTTTTATGAGACTGGATTAAATGTTCCTCGGGATCAGCTGCAGGGCAT
GTTGTATAGTTTGGTTGGAGGCCAGGGGAGTGAGAGGCTGTCTTCAATGAATCTTGGGTATAAACACTACCAGGGTATTGACAACTACCC
CCTGGACTGGGAACTGTCGTATGCCTACTACAGCAACATTGCCACCAAGACACCCCTTGACCAGCACACACTGCAAGGAGATCAGGCATA
TGTTGAAACAATTAGACTAAAAGATGATGAAATACTCAAGGTACAAACCAAAGAAGATGGAGATGTCTTTATGTGGTTGAAGCATGAAGC
TACCCGAGGCAATGCAGCAGCTCAGCAACGATTGGCCCAGATGCTGTTCTGGGGGCAGCAAGGTGTGGCCAAGAATCCCGAAGCAGCAAT
TGAGTGGTACGCCAAGGGCGCCCTGGAGACGGAGGATCCTGCGTTAATCTATGACTATGCCATTGTGCTATTCAAGGGTCAAGGAGTAAA
AAAGAACAGACGGCTTGCCTTAGAGCTGATGAAGAAAGCAGCTTCCAAGGGATTGCATCAGGCAGTCAATGGCCTGGGATGGTATTACCA
CAAATTCAAGAAAAATTACGCCAAAGCAGCAAAGTACTGGTTAAAAGCAGAAGAAATGGGGAACCCAGATGCGTCATACAATCTTGGAGT
CCTGCATTTGGATGGCATCTTCCCTGGAGTTCCTGGAAGGAATCAAACTTTAGCTGGTGAATATTTCCATAAGGCTGCGCAAGGTGGACA
CATGGAAGGGACCTTGTGGTGTTCTCTCTACTATATCACAGGCAACCTGGAGACATTCCCTAGAGATCCTGAGAAAGCTGTTGTATGGGC
AAAACATGTAGCTGAGAAAAATGGCTACTTGGGCCATGTCATCCGCAAAGGCCTCAATGCCTACCTGGAAGGTTCATGGCATGAAGCTTT
GCTGTATTATGTTTTAGCAGCAGAAACTGGAATTGAAGTGTCACAGACAAATTTAGCACACATCTGTGAGGAGAGGCCAGACCTGGCCAG
GAGATACTTGGGTGTTAACTGTGTTTGGAGATACTATAATTTCTCTGTTTTTCAAATCGATGCTCCTTCCTTTGCATATTTGAAGATGGG
AGACCTTTACTACTATGGCCACCAAAACCAGTCACAAGACCTGGAGTTGTCTGTGCAGATGTACGCCCAAGCCGCCCTGGATGGAGACTC
CCAGGGATTTTTTAACCTGGCCCTGCTAATCGAGGAAGGTACGATAATCCCACACCATATCTTGGATTTCTTGGAAATTGACTCAACTCT
CCATTCTAATAACATCTCCATTCTCCAGGAACTGTACGAAAGGTGCTGGAGCCACAGTAACGAGGAGTCCTTCAGCCCCTGCTCCTTGGC
CTGGCTTTACCTGCACTTGCGGCTTCTCTGGGGTGCTATCCTGCACTCAGCCCTGATCTACTTTCTGGGAACCTTTCTGCTATCCATATT
GATCGCCTGGACTGTGCAGTATTTCCAGTCTGTCTCAGCAAGCGATCCCCCTCCAAGACCATCCCAGGCCTCCCCAGACACTGCCACGTC
CACTGCAAGTCCAGCTGTGACTCCAGCTGCAGATGCCTCTGACCAAGACCAGCCCACAGTAACTAATAACCCGGAGCCACGTGGGTGAAC
TGTGCACTCCAGTTCTCTCCAGATGAGAGAGAATCTTTTCAACAGCTGGTATTGGGAAGCTGGGGCCAGGGCATGATCCTGATAAACACC

>73079_73079_3_RBPJ-SEL1L3_RBPJ_chr4_26322670_ENST00000348160_SEL1L3_chr4_25835191_ENST00000502949_length(amino acids)=855AA_BP=10
MWKMAPVVTGFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVKTKFIIPLKEWFRLDISFNGGQI
VVTTSIGQDLKSYHNQTISFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPLLEKQLAEQIKLYYERCAEVQEI
VSVYASAAKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRNQNESVSEIGGKIFEKAVKRLSS
IDGLHQISSIVPFLTDSSCCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGIDNYPLDWELSYAYYSNI
ATKTPLDQHTLQGDQAYVETIRLKDDEILKVQTKEDGDVFMWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDP
ALIYDYAIVLFKGQGVKKNRRLALELMKKAASKGLHQAVNGLGWYYHKFKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIFPGVPGR
NQTLAGEYFHKAAQGGHMEGTLWCSLYYITGNLETFPRDPEKAVVWAKHVAEKNGYLGHVIRKGLNAYLEGSWHEALLYYVLAAETGIEV
SQTNLAHICEERPDLARRYLGVNCVWRYYNFSVFQIDAPSFAYLKMGDLYYYGHQNQSQDLELSVQMYAQAALDGDSQGFFNLALLIEEG
TIIPHHILDFLEIDSTLHSNNISILQELYERCWSHSNEESFSPCSLAWLYLHLRLLWGAILHSALIYFLGTFLLSILIAWTVQYFQSVSA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RBPJ-SEL1L3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RBPJ-SEL1L3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RBPJ-SEL1L3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource